Fixing device for mouse caudal vein medicine injection

Abstract

The utility model relates to a fixing device for mouse caudal vein medicine injection, in particular to a height adjusting plate capable of being adjusted up and down and used for being matched with mice with different body heights, a width adjusting plate capable of being adjusted left and right and used for being matched with mice with different body widths, and a limiting adjusting column capable of being adjusted front and back. The width adjusting plates are used for being matched with mice with different body lengths, the fixing device can effectively fix the mice with different body sizes through cooperation of the structures, in addition, gaps are formed between the width adjusting plates, the mice can be conveniently dragged into the fixing device to be fixed in the mode that the tails of the mice are lifted to pass through the gaps, and the fixing device is simple and rapid.

Description

Technical Field

[0001] This utility model belongs to the field of animal experiments, and specifically relates to a fixation device for drug injection into the tail vein of mice. Background Technology

[0002] The significance of tail vein injection in mice lies in its provision of a direct method for introducing drugs into the bloodstream, which is crucial for studying drug efficacy, metabolic kinetics, and toxicity. Furthermore, it is an effective tool for creating disease models, studying immune responses, conducting gene and cell therapies, and performing imaging analyses, and is widely used in biomedical research to help scientists understand disease mechanisms and develop new treatments.

[0003] To ensure the success rate of drug injection via the tail vein in mice, the mice need to be restrained using a fixation device before injection. However, existing fixation devices are inconvenient to use, mainly due to the following reasons:

[0004] On the one hand, most existing mouse restraint devices can only be adjusted according to the length of the mouse's body, and cannot be effectively adjusted according to the height and width of the mouse's body. This causes the mouse's trunk to swing from side to side during the drug injection process, which in turn causes the mouse's tail to swing significantly, resulting in operation failure.

[0005] On the other hand, most existing mouse restraint devices are long and thin cylindrical structures, and the internal space of the restraint device is basically the same as the size of the mouse. This makes it difficult for operators to insert the mouse into the restraint device or to take the mouse out of the restraint device, which can easily cause the mouse to escape. Utility Model Content

[0006] The purpose of this invention is to provide a fixation device for drug injection via the tail vein of mice, thereby solving the problems mentioned in the background art. To achieve this purpose, the specific technical solution is as follows:

[0007] A fixation device for drug injection via the tail vein of mice includes vertical plates fixedly installed on the left and right sides of the top surface of a base plate. Several vertically arranged slots are provided on the adjacent surfaces of the two vertical plates, through which height adjustment plates with several regularly arranged through holes at the top are installed. There is a gap between the left and right height adjustment plates. The top of the width adjustment plate has a strip-like structure, and the bottom has several column-like structures. The width adjustment plate is inserted into the two side height adjustment plates through column-like structures at its bottom that match the through holes. Several limiting adjustment columns are also inserted into the through holes. Through the cooperation of the height adjustment plate, width adjustment plate, and limiting adjustment columns, a space for fixing the mouse is formed on the base plate.

[0008] Furthermore, a second base plate is fixedly installed in front of the base plate, and the second base plate is provided with a placement groove for placing the mouse tail.

[0009] Furthermore, a number of fixing straps spanning the placement slots are provided on the second base plate. One end of the fixing strap is fixed to the second base plate, and the other end is attached to the second base plate by a Velcro structure.

[0010] The beneficial effects of this utility model are:

[0011] (1) By setting an adjustable height adjustment plate, a width adjustment plate and a limiting adjustment column, the space size enclosed by the height adjustment plate, the width adjustment plate and the limiting adjustment column on the base plate can be flexibly adjusted according to the body size of the mouse, so that the mouse can be effectively fixed and the torso swinging of the mouse during the injection process is avoided, thus providing a guarantee for the injection operation.

[0012] (2) The left and right width adjustment plates of this utility model have gaps, and the limiting adjustment column installed on the left and right width adjustment plates also has gaps. By lifting the mouse by the tail through the gaps, the mouse can be quickly and easily dragged into the fixed space. When it is necessary to take the mouse out of the fixed space, the mouse can be quickly and easily dragged out of the fixed space by lifting the mouse by the tail. During the above operation, the operator does not need to put his / her hand into the narrow fixed space to operate, so the operation is more convenient and faster. At the same time, since the operator can hold the mouse by the tail throughout the operation, it is not easy for the mouse to escape. Attached Figure Description

[0013] Figure 1 This is a front view of the first embodiment;

[0014] Figure 2 This is a top view of the first embodiment;

[0015] Figure 3 This is the right view of the first embodiment;

[0016] Figure 4 This is a top view of the height adjustment plate in the first embodiment;

[0017] Figure 5 This is the right view of the width adjustment plate in the first embodiment;

[0018] Figure 6 This is a front view of the limit adjustment column in the first embodiment;

[0019] Figure 7 This is a front view of the second embodiment;

[0020] Figure 8 This is a top view of the second embodiment;

[0021] Figure 9 This is the right view of the second embodiment;

[0022] Figure 10 This is a front view of the third embodiment;

[0023] Figure 11 This is a top view of the third embodiment;

[0024] Figure 12 This is the right view of the third embodiment;

[0025] The meanings of the symbols in the image are as follows:

[0026] 1. Base plate; 2. Vertical plate; 3. Slot; 4. Through hole; 5. Height adjustment plate; 6. Width adjustment plate; 7. Limit adjustment column; 8. Second base plate; 9. Placement slot; 10. Fixing strap. Detailed Implementation

[0027] Reference Figure 1-6 This embodiment provides a fixation device for drug injection via the tail vein of mice. Vertical plates 2 are fixedly installed on the left and right sides of the top surface of the base plate 1. Several vertically arranged slots 3 are provided on the adjacent surfaces of the two vertical plates 2. Height adjustment plates 5 with several regularly arranged through holes 4 on the top are installed through the slots 3, and there is a gap between the left and right height adjustment plates 5. The top of the width adjustment plate 6 is a strip structure and the bottom is several column structures. The width adjustment plate 6 is inserted into the two side height adjustment plates 5 through the column structures at its bottom that match each through hole 4. Several limiting adjustment columns 7 are also inserted into the through holes 4. Through the cooperation of the height adjustment plate 5, the width adjustment plate 6, and the limiting adjustment columns 7, a space for fixing the mouse is formed on the base plate 1.

[0028] Before use, adjust the entire restraint device according to the mouse's size. Specifically, insert the two height adjustment plates 5 into the slots 3 at appropriate heights to adjust the height of the mouse restraint space. Then, insert the two width adjustment plates 6 into the appropriate through holes 4 on the height adjustment plates 5 to adjust the width of the mouse restraint space. Next, insert the limiting adjustment post 7 into the through hole 4 at the front end of the two height adjustment plates 5, located between the two width adjustment plates 6. At this point, the height adjustment plates 5, width adjustment plates 6, and limiting adjustment post 7 form a restraint space with a rear opening on the top surface of the base plate 1. Then, the operator lifts the mouse by the tail with one hand, allowing the mouse's tail to enter the two sides from the rear. The gap between the height adjustment plates 5 is widened, and the mouse is dragged forward until its buttocks contact the limiting adjustment post 7 at the front end of the base plate 1. At this time, the mouse's tail is outside the fixed space enclosed by the height adjustment plates 5, width adjustment plates 6, and limiting adjustment posts 7 on the top surface of the base plate 1. Then, the operator holds the mouse by its tail and inserts several other limiting adjustment posts 7 into the through holes 4 between the two width adjustment plates 6 that are closest to the mouse's head, thereby blocking the rear opening of the fixed space. Through the above steps, the mouse is fixed in a fixed space that fits its body shape and cannot be escaped, enclosed by the height adjustment plates 5, width adjustment plates 6, and limiting adjustment posts 7 on the top surface of the base plate 1.

[0029] After the mouse is secured, the operator can inject the drug into the mouse's tail vein. After the injection, the operator holds the mouse by the tail, pulls out the limiting adjustment post 7 located at the mouse's buttocks, opens the front of the fixation space, and pulls the mouse out.

[0030] Reference Figure 7-9 The second embodiment, based on the first embodiment, has a second base plate 8 fixedly installed in front of the base plate 1. The second base plate 8 is provided with a placement groove 9 for placing the mouse tail, so that the mouse tail can be better fixed and slipped when the mouse is injected with drugs via the tail vein.

[0031] Reference Figure 10-12 The third embodiment, based on the second embodiment, provides several fixing straps 10 that span the placement slots 9 on the second base plate 8. One end of the fixing strap 10 is fixed to the second base plate 8, and the other end is attached to the second base plate 8 by a Velcro structure. Each fixing strap 10 replaces the operator in holding down the mouse tail, making it easier for the operator to perform the injection operation.

Claims

1. A fixation device for drug injection via the tail vein of mice, characterized in that, Vertical plates (2) are fixedly installed on the left and right sides of the top surface of the base plate (1). Several vertically arranged slots (3) are provided on the adjacent surfaces of the two vertical plates (2). A height adjustment plate (5) with several regularly arranged through holes (4) is installed through the slots (3). There is a gap between the left and right height adjustment plates (5). The top of the width adjustment plate (6) is a strip structure and the bottom is a column structure. The width adjustment plate (6) is inserted into the two side height adjustment plates (5) through the column structure at its bottom that matches each through hole (4). Several limiting adjustment columns (7) are also inserted into the through holes (4). Through the cooperation of the height adjustment plate (5), the width adjustment plate (6), and the limiting adjustment columns (7), a space for fixing the mouse is formed on the base plate (1).

2. The fixation device for mouse tail vein drug injection according to claim 1, characterized in that, A second base plate (8) is fixedly installed in front of the base plate (1), and a placement slot (9) for placing the mouse tail is provided on the second base plate (8).

3. The fixation device for mouse tail vein drug injection according to claim 2, characterized in that, Several fixing straps (10) are provided on the second base plate (8) and span the placement groove (9). One end of the fixing strap (10) is fixed to the second base plate (8), and the other end is glued to the second base plate (8) by a Velcro structure.

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