Portable sampling device for endometrial cancer gene methylation detection

Abstract

The utility model discloses a portable sampling device for endometrial cancer gene methylation detection in the technical field of sampling devices, which comprises an extraction cylinder, one end of the extraction cylinder is fixedly inserted with a connecting pipe, the inner wall of the connecting pipe is movably inserted with a detachable extraction pipe, and the inner wall of the detachable extraction pipe is movably inserted with a connecting pipe. A plurality of guide blocks are fixedly arranged on the outer wall of the end, inserted into the connecting pipe, of the detachable extraction pipe, the guide blocks are in sliding fit with the inner wall of the connecting pipe, and two toothed plate sealing pieces used for blocking the connecting pipe are movably arranged on the inner wall of the extraction cylinder; after the device is used, the grab handle is firstly detached, then the detachable extraction pipe is detached, and at the moment, the guide block slides along the inner wall of the connecting pipe, so that the connecting pipe drives the transmission gear to rotate reversely, and the two toothed plate sealing pieces are reset along with the reverse rotation of the transmission gear to seal the connecting pipe; therefore, the possibility that external sundries enter the extraction barrel through the connecting pipe when the device is not used is reduced.

Description

Technical Field

[0001] This utility model relates to the field of sampling device technology, and in particular to a portable sampling device for detecting gene methylation in endometrial cancer. Background Technology

[0002] DNA methylation is an important mechanism for gene expression regulation. DNA methylation detection refers to the determination of the degree of DNA methylation in tumor cells using various methods. In the development of malignant tumors, the methylation state is not constant. The degree of hypomethylation of the whole genome in tumor cells is closely related to disease progression, tumor size, and malignancy. DNA methylation detection is of great significance in judging the degree of tumor malignancy. In the process of DNA methylation detection, a sampling device is needed to sample the DNA methylation before it can be brought back to the laboratory for testing. The methylation detection of endometrial cancer genes also requires the use of a sampling device.

[0003] An existing patent (publication number: CN215492651U) discloses a portable sampling device for methylation detection, belonging to the field of medical device technology. This portable sampling device includes a housing and a sampling tube. A micro servo motor is fixedly mounted on the top of the housing, and a main gear is fixedly mounted on the output end of the micro servo motor. By inserting the sampling tube into the interior of a third fixing sleeve, the position of the sampling tube can be restricted by a limiting plate. Then, by rotating the sampling tube, the limiting plate engages with the slot, thus fixing the fixing plate and the first fixing sleeve. However, this technical solution still has shortcomings, specifically as follows:

[0004] The current device uses a fixing sleeve and a limiting mechanism to install the sampling tube. However, the fixing sleeve has an open structure, which allows external air to easily enter the device when the sampling tube is disassembled. Therefore, we propose a portable sampling device for endometrial cancer gene methylation detection to address the aforementioned problems. Utility Model Content

[0005] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of the present invention, to avoid obscuring the purpose of these documents, and such simplifications or omissions should not be construed as limiting the scope of the present invention.

[0006] Therefore, the purpose of this utility model is to provide a portable sampling device for detecting gene methylation in endometrial cancer, which can solve the problem that existing devices use a fixing sleeve and a limiting mechanism to install the sampling tube. However, the fixing sleeve has an open structure, and when the sampling tube is disassembled, external air can easily enter the device through the opening of the fixing sleeve.

[0007] To solve the above-mentioned technical problems, this utility model provides a portable sampling device for detecting endometrial cancer gene methylation, which adopts the following technical solution: it includes an extraction tube, one end of which is fixedly connected to a connecting tube, and a detachable extraction tube is movably inserted into the inner wall of the connecting tube. Several guide blocks are fixedly provided on the outer wall of the end of the detachable extraction tube inserted into the connecting tube. The guide blocks slide in cooperation with the inner wall of the connecting tube. Two toothed sealing members for sealing the connecting tube are movably provided on the inner wall of the extraction tube. A transmission gear is fixedly sleeved on the end of the connecting tube inserted into the extraction tube, and the transmission gear meshes with the two toothed sealing members.

[0008] A gear rod is rotatably installed inside the extraction cylinder, and a piston disc is threaded onto the gear rod. A transmission rod is movably inserted into the inner bottom wall of the extraction cylinder. A driving component is provided at the left end of the extraction cylinder. The transmission rod meshes with the gear rod and the driving component. A handle is threaded into the bottom of the extraction cylinder, and the upper end of the handle abuts against the lower end of the transmission rod.

[0009] By adopting the above technical solution, this solution first installs the handle on the extraction cylinder and pushes the transmission rod upward, thereby making the transmission rod mesh with the gear rod and the drive component. Then, the detachable extraction tube is inserted into the connecting tube, and the guide block is inserted into the connecting tube, thereby causing the connecting tube to drive the transmission gear to rotate and causing the two toothed plate seals to move in opposite directions, thereby causing the connecting tube to open. Then, the drive component is activated to drive the transmission rod and the gear rod to rotate. As the gear rod rotates, it is easy to control the movement of the piston disc. As the piston disc moves, it is easy to extract the sample through the detachable extraction tube.

[0010] Optionally, the extraction cylinder is fixedly provided with two partition plates inside, and the internal cavity of the extraction cylinder is divided into a transmission cavity, an extraction cavity and a sealing cavity from left to right.

[0011] By adopting the above technical solution, this solution realizes the transmission of device components through the transmission cavity, collects the extracted samples through the extraction cavity, and facilitates the installation of the toothed plate seal of the device through the sealing cavity.

[0012] Optionally, the bottom of the extraction cylinder is fixedly provided with an internally threaded cylinder, the handle is threaded into the internally threaded cylinder, the upper end of the transmission rod is movably sleeved with a first bevel gear, the transmission rod is connected to the inner wall of the extraction cylinder through a sleeved spring, and the lower end of the transmission rod passes through the extraction cylinder, inserts into the internally threaded cylinder, and abuts against the upper end of the handle.

[0013] By adopting the above technical solution, this solution facilitates the installation of the handle on the extraction cylinder through the internal threaded cylinder. When the handle is inserted into the extraction cylinder, it pushes the transmission rod and the first bevel gear to move upward, and causes the spring to stretch and deform.

[0014] Optionally, the inner wall of the connecting tube is provided with a number of spiral grooves corresponding to the number of guide blocks, and when the detachable extraction tube is inserted into the connecting tube, the guide blocks slide in contact with the inner wall of the spiral grooves.

[0015] By adopting the above technical solution, when the detachable extraction tube is inserted into the connecting tube, the guide block is inserted into the spiral groove, which causes the connecting tube to drive the transmission gear to rotate. As the transmission gear rotates, it is easy to control the opening and closing of the toothed plate seal.

[0016] Optionally, magnetic blocks are provided at the right end of the extraction cylinder and on the outer wall of the detachable extraction tube, and the two magnetic blocks attract each other when the detachable extraction tube is inserted into the connecting tube.

[0017] By adopting the above technical solution, when the detachable extraction tube is inserted into the connecting tube, it is attracted by two magnetic blocks, thereby reducing the possibility of the detachable extraction tube falling off automatically.

[0018] Optionally, two limiting grooves are provided on the left end of the inner wall of the extraction cylinder sealing cavity. The toothed plate seal includes a sealing plate, a transmission toothed plate and a limiting block. The sealing plate abuts against one end of the connecting pipe inserted into the extraction cylinder. The transmission toothed plate is fixedly provided with the side wall of the sealing plate and meshes with the transmission gear. The limiting block is fixedly provided with the side wall of the transmission toothed plate. The limiting block is inserted into the limiting groove and slides with the inner wall of the limiting groove.

[0019] By adopting the above technical solution, this solution facilitates the limiting of the transmission gear plate and the sealing plate through the cooperation of the limiting groove and the limiting block, so that the sealing plate, the transmission gear plate and the limiting block can only slide along the inner wall of the limiting groove.

[0020] Optionally, the gear rod has an external thread, the left end of the gear rod passes through the partition plate and meshes with the first bevel gear, the piston disc is threaded onto the gear rod, and a limit strip is fixedly provided on the outer wall of the piston disc, the limit strip slidingly engaging with the inner wall of the extraction cavity of the extraction cylinder.

[0021] By adopting the above technical solution, this solution facilitates the limiting of the piston disc through the limiting strip. When the driving component drives the first bevel gear to rotate, it drives the gear rod to rotate synchronously. As the gear rod rotates, it controls the piston disc to move along the axial direction of the gear rod.

[0022] Optionally, the driving component includes a motor and a second bevel gear. The motor is fixedly mounted on the left end of the extraction cylinder, and the second bevel gear is fixedly sleeved on the rotating shaft of the motor. The second bevel gear meshes with the first bevel gear.

[0023] By adopting the above technical solution, this solution facilitates the rotation of the second bevel gear by the motor, which in turn facilitates the rotation of the first bevel gear and the gear rod. As the gear rod rotates, it is easy to control the movement of the piston disc within the extraction chamber.

[0024] In summary, this utility model has at least one of the following beneficial effects:

[0025] After the device is finished using it, first remove the handle, and then remove the detachable extraction tube. At this time, the guide block slides along the inner wall of the connecting tube, which causes the connecting tube to drive the transmission gear to rotate in the opposite direction. As the transmission gear rotates in the opposite direction, it causes the two toothed plate seals to reset and seal the connecting tube, thereby reducing the possibility of external debris entering the extraction tube through the connecting tube when the device is not in use, and making it easier to seal the device.

[0026] When the handle is removed, the transmission rod loses its thrust. At this time, the spring pulls the transmission rod and the first bevel gear downward, thereby causing the first bevel gear to separate from the gear rod and the drive component. This reduces the possibility that the device may be damaged due to the sealed state inside the device and the suction force generated when the drive component is accidentally started. Attached Figure Description

[0027] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Fig. 1 This is a three-dimensional structural diagram of the present invention;

[0029] Fig. 2 This is a partial three-dimensional unfolded cross-sectional view of the extraction tube of this utility model;

[0030] Fig. 3 This is a partial three-dimensional unfolded cross-sectional view of the connecting pipe of this utility model.

[0031] Explanation of reference numerals in the attached drawings: 1. Extraction tube; 2. Connecting tube; 21. Spiral groove; 3. Detachable extraction tube; 4. Guide block; 5. Toothed plate seal; 51. Sealing plate; 52. Transmission toothed plate; 53. Limiting block; 6. Transmission gear; 7. Gear rod; 8. Piston disc; 81. Limiting strip; 9. Transmission rod; 91. First bevel gear; 92. Spring; 10. Driving component; 101. Motor; 102. Second bevel gear; 11. Handle; 12. Divider plate; 13. Internally threaded cylinder; 14. Magnetic block; 15. Limiting groove; 16. Transmission cavity; 17. Extraction cavity; 18. Sealing cavity. Detailed Implementation

[0032] The following is in conjunction with the appendix Figs. 1-3 The present invention will be described in further detail below.

[0033] Example 1, refer to Figs. 1-3 In this embodiment, in order to solve the problem that existing devices use a fixing sleeve and a limiting mechanism to install the sampling tube, but the fixing sleeve has an open structure, and when the sampling tube is disassembled, external air can easily enter the device through the opening of the fixing sleeve, this utility model discloses a portable sampling device for detecting endometrial cancer gene methylation.

[0034] The device includes an extraction tube 1, with a connecting tube 2 fixedly inserted into one end of the extraction tube 1. A detachable extraction tube 3 is movably inserted into the inner wall of the connecting tube 2. Several guide blocks 4 are fixedly provided on the outer wall of the end of the detachable extraction tube 3 that is inserted into the connecting tube 2. The guide blocks 4 slide and cooperate with the inner wall of the connecting tube 2. When the operator inserts the detachable extraction tube 3 into the connecting tube 2, it causes the guide blocks 4 to be inserted into the connecting tube 2, thereby causing the connecting tube 2 to rotate.

[0035] The inner wall of the extraction cylinder 1 is movably provided with two toothed plate seals 5 for sealing the connecting pipe 2. The inside of the extraction cylinder 1 is fixedly provided with two partition plates 12. The internal cavity of the extraction cylinder 1 is divided into a transmission cavity 16, an extraction cavity 17 and a sealing cavity 18 from left to right. The partition plates 12 facilitate the division of the internal cavity of the extraction cylinder 1 into the transmission cavity 16, the extraction cavity 17 and the sealing cavity 18 from left to right. The transmission cavity 16 realizes the transmission of the device components, the extraction cavity 17 collects the extracted samples, and the sealing cavity 18 facilitates the installation of the toothed plate seals 5 of the device.

[0036] One end of the connecting tube 2 inserted into the extraction tube 1 is fixedly fitted with a transmission gear 6. The transmission gear 6 meshes with two toothed plate seals 5. The inner wall of the connecting tube 2 has a number of spiral grooves 21 corresponding to the number of guide blocks 4. When the detachable extraction tube 3 is inserted into the connecting tube 2, the guide block 4 slides in cooperation with the inner wall of the spiral groove 21. When the detachable extraction tube 3 is inserted into the connecting tube 2, the guide block 4 is inserted into the spiral groove 21, which causes the connecting tube 2 to drive the transmission gear 6 to rotate. As the transmission gear 6 rotates, it is easy to control the opening and closing of the toothed plate seals 5. When the detachable extraction tube 3 is inserted into the connecting tube 2, its end passes through the partition plate 12 at the right end and is inserted into the extraction cavity 17.

[0037] A gear rod 7 is rotatably installed inside the extraction cylinder 1, and a piston disc 8 is threaded onto the gear rod 7. A transmission rod 9 is movably inserted into the inner bottom wall of the extraction cylinder 1. A driving component 10 is provided at the left end of the extraction cylinder 1. The transmission rod 9, gear rod 7, and driving component 10 mesh. By starting the driving component 10, the transmission rod 9 and gear rod 7 are driven to rotate. As the gear rod 7 rotates, it is easy to control the movement of the piston disc 8. As the piston disc 8 moves, it is easy to extract the sample through the detachable extraction tube 3.

[0038] A handle 11 is threaded into the bottom of the extraction cylinder 1. The upper end of the handle 11 abuts against the lower end of the transmission rod 9. An internally threaded cylinder 13 is fixedly installed at the bottom of the extraction cylinder 1, and the handle 11 is threaded into the internally threaded cylinder 13. A first bevel gear 91 is movably sleeved on the upper end of the transmission rod 9. The transmission rod 9 is connected to the inner wall of the extraction cylinder 1 through a sleeved spring 92. The lower end of the transmission rod 9 passes through the extraction cylinder 1, inserts into the internally threaded cylinder 13, and abuts against the upper end of the handle 11. The internally threaded cylinder 13 facilitates the extraction of the extraction cylinder 1. The handle 11 is installed on the extraction cylinder 1. When the handle 11 is inserted into the extraction cylinder 1, it pushes the transmission rod 9 and the first bevel gear 91 to move upward, and causes the spring 92 to stretch and deform. When the handle 11 is removed, the transmission rod 9 loses its thrust. At this time, the spring 92 pulls the transmission rod 9 and the first bevel gear 91 downward, thereby causing the first bevel gear 91 to separate from the gear rod 7 and the drive component 10. This reduces the possibility that the device may be damaged due to the sealed state inside the device and the suction force generated when the drive component 10 is accidentally started.

[0039] The specific working principle is as follows: After the device is used, the handle 11 is removed first, and then the detachable extraction tube 3 is removed. At this time, the guide block 4 slides along the inner wall of the connecting tube 2, thereby causing the connecting tube 2 to drive the transmission gear 6 to rotate in the opposite direction. As the transmission gear 6 rotates in the opposite direction, the two toothed plate seals 5 are reset to seal the connecting tube 2, thereby reducing the possibility of external debris entering the extraction cylinder 1 through the connecting tube 2 when the device is not in use, and making it easier to seal the device.

[0040] Example 2, refer to Figs. 2-3Based on the same concept as in Embodiment 1 above, this portable sampling device for detecting endometrial cancer gene methylation further includes:

[0041] Two limiting grooves 15 are provided on the left end of the inner wall of the sealing cavity 18 of the extraction cylinder 1. The toothed sealing component 5 includes a sealing plate 51, a transmission toothed plate 52 and a limiting block 53. The sealing plate 51 and the end of the connecting pipe 2 inserted into the extraction cylinder 1 abut against each other. The transmission toothed plate 52 is fixedly provided with the side wall of the sealing plate 51 and meshes with the transmission gear 6. The limiting block 53 is fixedly provided with the side wall of the transmission toothed plate 52. The limiting block 53 is inserted into the limiting groove 15 and slides with the inner wall of the limiting groove 15. The limiting groove 15 and the limiting block 53 cooperate to limit the transmission toothed plate 52 and the sealing plate 51, so that the sealing plate 51, the transmission toothed plate 52 and the limiting block 53 can only slide along the inner wall of the limiting groove 15. When the connecting pipe 2 drives the transmission gear 6 to rotate, it drives the transmission toothed plate 52 to move, and then the transmission toothed plate 52 drives the sealing plate 51 to move, so as to facilitate the control of the opening and closing of the connecting pipe 2.

[0042] The gear rod 7 has an external thread. The left end of the gear rod 7 passes through the partition plate 12 and meshes with the first bevel gear 91. The piston disc 8 is threaded onto the gear rod 7. A limiting strip 81 is fixedly provided on the outer wall of the piston disc 8. The limiting strip 81 slides with the inner wall of the extraction cavity 17 of the extraction tube 1. The limiting strip 81 facilitates the limiting of the piston disc 8. When the driving member 10 drives the first bevel gear 91 to rotate, it drives the gear rod 7 to rotate synchronously. As the gear rod 7 rotates, it controls the piston disc 8 to move along the axial direction of the gear rod 7. As the piston disc 8 moves, it facilitates the suction of the sample into the extraction cavity 17 through the detachable extraction tube 3.

[0043] The driving component 10 includes a motor 101 and a second bevel gear 102. The motor 101 is fixedly mounted on the left end of the extraction cylinder 1, and the second bevel gear 102 is fixedly mounted on the rotating shaft of the motor 101. The second bevel gear 102 meshes with the first bevel gear 91. The motor 101 facilitates the rotation of the second bevel gear 102, which in turn facilitates the rotation of the first bevel gear 91 and the gear rod 7. As the gear rod 7 rotates, it facilitates the control of the piston disc 8 moving within the extraction chamber 17.

[0044] The specific working principle is as follows: First, the handle 11 is installed on the extraction cylinder 1 and the transmission rod 9 is pushed upward, so that the transmission rod 9 meshes with the gear rod 7 and the driving component 10. The detachable extraction tube 3 is inserted into the connecting tube 2, and the guide block 4 is inserted into the connecting tube 2, so that the connecting tube 2 drives the transmission gear 6 to rotate, and causes the two toothed plate seals 5 to move in opposite directions, so that the connecting tube 2 opens. Then, the driving component 10 is started to drive the transmission rod 9 and the gear rod 7 to rotate. As the gear rod 7 rotates, it is easy to control the movement of the piston disc 8. As the piston disc 8 moves, it is easy to extract the sample through the detachable extraction tube 3.

[0045] Example 3, refer to Figs. 2-3 Based on the same concept as in Embodiment 1 above, this portable sampling device for detecting endometrial cancer gene methylation further includes:

[0046] Both the right end of the extraction tube 1 and the outer wall of the detachable extraction tube 3 are provided with magnetic blocks 14. When the detachable extraction tube 3 is inserted into the connecting tube 2, the two magnetic blocks 14 are attracted together.

[0047] The specific working principle is as follows: when the detachable extraction tube 3 is inserted into the connecting tube 2, it is attracted by two magnetic blocks 14, thereby reducing the possibility of the detachable extraction tube 3 falling off automatically.

[0048] The above are all preferred embodiments of this utility model, and are not intended to limit the scope of protection of this utility model. Therefore, all equivalent changes made to the structure, shape and principle of this utility model should be covered within the scope of protection of this utility model.

Claims

1. A portable sampling device for detecting gene methylation in endometrial cancer, comprising an extraction tube (1), characterized in that: One end of the extraction tube (1) is fixedly connected to a connecting tube (2), and a detachable extraction tube (3) is movably inserted into the inner wall of the connecting tube (2). Several guide blocks (4) are fixedly provided on the outer wall of the detachable extraction tube (3) at the end inserted into the connecting tube (2). The guide blocks (4) slide with the inner wall of the connecting tube (2). Two toothed plate seals (5) for sealing the connecting tube (2) are movably provided on the inner wall of the extraction tube (1). A transmission gear (6) is fixedly sleeved on one end of the connecting tube (2) inserted into the extraction tube (1). The transmission gear (6) meshes with the two toothed plate seals (5). A gear rod (7) is rotatably installed inside the extraction cylinder (1). A piston disc (8) is threaded onto the gear rod (7). A transmission rod (9) is movably inserted into the inner bottom wall of the extraction cylinder (1). A driving member (10) is provided at the left end of the extraction cylinder (1). The transmission rod (9) meshes with the gear rod (7) and the driving member (10). A handle (11) is threaded into the bottom of the extraction cylinder (1). The upper end of the handle (11) abuts against the lower end of the transmission rod (9).

2. The portable sampling device for detecting endometrial cancer gene methylation according to claim 1, characterized in that: The extraction cylinder (1) has two fixed partition plates (12) inside. The internal cavity of the extraction cylinder (1) is divided into a transmission cavity (16), an extraction cavity (17) and a sealing cavity (18) from left to right.

3. The portable sampling device for detecting endometrial cancer gene methylation according to claim 2, characterized in that: The bottom of the extraction cylinder (1) is fixedly provided with an internal threaded cylinder (13), the handle (11) is threaded into the internal threaded cylinder (13), the upper end of the transmission rod (9) is movably sleeved with a first bevel gear (91), the transmission rod (9) is connected to the inner wall of the extraction cylinder (1) through a sleeved spring (92), the lower end of the transmission rod (9) passes through the extraction cylinder (1) and inserts into the internal threaded cylinder (13) and abuts against the upper end of the handle (11).

4. The portable sampling device for detecting endometrial cancer gene methylation according to claim 1, characterized in that: The inner wall of the connecting tube (2) is provided with a number of spiral grooves (21) corresponding to the number of guide blocks (4). When the detachable extraction tube (3) is inserted into the connecting tube (2), the guide block (4) slides in conjunction with the inner wall of the spiral groove (21).

5. The portable sampling device for detecting endometrial cancer gene methylation according to claim 1, characterized in that: The right end of the extraction tube (1) and the outer wall of the detachable extraction tube (3) are both provided with magnetic blocks (14). When the detachable extraction tube (3) is inserted into the connecting tube (2), the two magnetic blocks (14) attract each other.

6. The portable sampling device for detecting endometrial cancer gene methylation according to claim 2, characterized in that: Two limiting grooves (15) are opened at the left end of the inner wall of the sealing cavity (18) of the extraction cylinder (1). The toothed sealing component (5) includes a sealing plate (51), a transmission toothed plate (52) and a limiting block (53). The sealing plate (51) and the end of the connecting pipe (2) inserted into the extraction cylinder (1) abut against each other. The transmission toothed plate (52) is fixedly provided with the side wall of the sealing plate (51) and meshes with the transmission gear (6). The limiting block (53) is fixedly provided with the side wall of the transmission toothed plate (52). The limiting block (53) is inserted into the limiting groove (15) and slides in cooperation with the inner wall of the limiting groove (15).

7. The portable sampling device for detecting endometrial cancer gene methylation according to claim 3, characterized in that: The gear rod (7) has an external thread. The left end of the gear rod (7) passes through the partition plate (12) and meshes with the first bevel gear (91). The piston disc (8) is threaded onto the gear rod (7). A limit strip (81) is fixedly provided on the outer wall of the piston disc (8). The limit strip (81) slides with the inner wall of the extraction cavity (17) of the extraction cylinder (1).

8. The portable sampling device for detecting endometrial cancer gene methylation according to claim 7, characterized in that: The driving component (10) includes a motor (101) and a second bevel gear (102). The motor (101) is fixedly installed at the left end of the extraction cylinder (1), and the second bevel gear (102) is fixedly sleeved on the rotating shaft of the motor (101). The second bevel gear (102) meshes with the first bevel gear (91).

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