Vacuum gradient drying device for cell phospholipid encapsulated resveratrol
By combining microwave heating with gradient cooling and negative pressure drying technology, the problem of ice crystal damage to resveratrol encapsulated in cell phospholipids during vacuum low-temperature drying was solved, achieving efficient drying effect and improved formulation stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI OLI ENTERPRISES CO LTD
- Filing Date
- 2025-05-29
- Publication Date
- 2026-04-28
AI Technical Summary
In existing technologies, resveratrol encapsulated in cell phospholipids suffers from reduced encapsulation efficiency due to ice crystal damage or structural collapse during vacuum low-temperature drying, and the drying time is also relatively long.
The method employs a combination of precise microwave penetration and selective heating, along with negative pressure pump extraction and cooling pipe cooling. Microwaves generated by a magnetron act on polar molecules to heat the ice crystal core, generating heat through molecular rotational friction. This is combined with gradient cooling and negative pressure conditions for drying.
It accelerates the ice crystal sublimation process, improves drying efficiency, avoids high-temperature damage, and enhances the long-term stability of the formulation.
Smart Images
Figure CN224175484U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of vacuum drying, and in particular to a vacuum gradient drying device for encapsulating resveratrol in cell phospholipids. Background Technology
[0002] To avoid damage to resveratrol encapsulated in cell phospholipids during high-temperature drying, vacuum drying technology can effectively solve the problem of decreased encapsulation rate caused by phase transition, ice crystal damage, or structural collapse of liposomes during the drying process, while improving the long-term stability of the formulation.
[0003] Vacuum low-temperature drying can sublimate the water inside resveratrol encapsulated in cell phospholipids, thereby drying the resveratrol. However, the time required for the low-temperature sublimation of internal water is relatively long, which is not conducive to the vacuum drying of resveratrol encapsulated in cell phospholipids. Utility Model Content
[0004] In view of this, the present invention provides a vacuum gradient drying device for encapsulating resveratrol in cell phospholipids. The main technical problem to be solved is to accelerate the ice crystal sublimation process through the precise penetration and selective heating of microwave energy.
[0005] To achieve the above objectives, the present invention adopts the following technical solution: a vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids, comprising an outer shell, an inner liner fixedly connected inside the outer shell, a cooling pipe fixedly connected to the left side wall of the inner liner, the inlet and outlet ports of the cooling pipe extending to the outside of the outer shell, multiple through holes on the back of the inner liner, a magnetron fixedly connected to the right side wall of the inner liner, a negative pressure pump fixedly connected to the top of the outer shell, an air extraction pipe fixedly connected to the input end of the negative pressure pump, the end of the air extraction pipe away from the negative pressure pump extending into the interior of the inner liner, and a door installed on the front of the inner liner.
[0006] By adopting the above technical solution, during use, the phospholipid-encapsulated resveratrol to be dried is placed into the inner liner, and coolant is continuously injected into the cooling pipe. The coolant absorbs heat from the outer shell and the inside of the inner liner, lowering the temperature of the phospholipid-encapsulated resveratrol inside the inner liner, causing the internal water to freeze into ice crystals. After the ice crystals sublimate, the drying of the phospholipid-encapsulated resveratrol is completed. Furthermore, changing the flow rate and volume of the coolant in the cooling pipe can adjust the temperature inside the inner liner, facilitating gradient cooling. At the same time, turning on the negative pressure pump can extract air from inside the inner liner, creating a negative pressure state inside the inner liner, which is beneficial for vacuum drying of the phospholipid-encapsulated resveratrol. Changing the working efficiency of the negative pressure pump can adjust the negative pressure state inside the inner liner, facilitating the gradual reduction of the air pressure inside the inner liner. Through the operation of the magnetron, microwaves can be generated to act on the residual polar molecules (such as unfrozen water molecules) in the phospholipid-encapsulated resveratrol. Heat is generated through molecular rotation and friction, directly heating the ice crystal core and increasing the drying efficiency of the phospholipid-encapsulated resveratrol.
[0007] As a further description of the above technical solution:
[0008] A first motor is fixedly connected to the inner left side of the outer casing. A first rotating shaft is fixedly connected to the output end of the first motor. A fan blade is fixedly connected to the end of the first rotating shaft away from the first motor.
[0009] By adopting the above technical solution, the fan blades are rotated by the operation of the first motor, which can diffuse the cold air around the cooling pipe into the inner tank, making it easier to reduce the temperature of resveratrol encapsulated by cell phospholipids.
[0010] As a further description of the above technical solution:
[0011] The bottom of the outer shell is fixedly connected to a base, the inside of the base is fixedly connected to a second motor, the output end of the second motor is fixedly connected to a second rotating shaft, and the end of the second rotating shaft away from the second motor is fixedly connected to a placement rack, which is located inside the inner liner.
[0012] By adopting the above technical solution, when using it, the cell phospholipid-encapsulated resveratrol is placed on the placement rack, and the placement rack is rotated by the operation of the second motor, which facilitates uniform cooling of the cell phospholipid-encapsulated resveratrol and uniform microwave heating.
[0013] As a further description of the above technical solution:
[0014] A temperature detector is fixedly connected inside the door body, and the temperature detector is located inside the inner liner.
[0015] By adopting the above technical solution, the temperature inside the inner liner is detected by a temperature detector.
[0016] As a further description of the above technical solution:
[0017] A display is fixedly connected to the front of the door.
[0018] By adopting the above technical solution, the value detected by the temperature detector is displayed on the screen.
[0019] As a further description of the above technical solution:
[0020] The cooling pipe has a corrugated structure and is filled with coolant.
[0021] By adopting the above technical solution, the corrugated structure of the cooling pipe can increase the contact area between the cooling pipe and the inner liner, and achieve the purpose of cooling by the flow of coolant in the cooling pipe.
[0022] By employing the above technical solution, the vacuum gradient drying device for encapsulating resveratrol with cell phospholipids of this invention has at least the following beneficial effects:
[0023] 1. Compared with existing technologies, this vacuum gradient drying device for phospholipid-encapsulated resveratrol involves placing the phospholipid-encapsulated resveratrol to be dried into the inner liner. Coolant is continuously injected into the cooling pipe, absorbing heat from the outer shell and the inner liner, thus lowering the temperature of the phospholipid-encapsulated resveratrol inside the liner. This causes the internal moisture to freeze into ice crystals, which then sublimate, completing the drying process. Furthermore, changing the flow rate and volume of the coolant in the cooling pipe allows for adjustment of the temperature inside the liner, facilitating gradient cooling. Simultaneously, activating the negative pressure pump extracts air from the inner liner, creating a negative pressure environment that promotes vacuum drying of the phospholipid-encapsulated resveratrol. Adjusting the working efficiency of the negative pressure pump allows for adjustment of the negative pressure state inside the liner, facilitating a gradual reduction in air pressure.
[0024] 2. Compared with the prior art, this vacuum gradient drying device for cell phospholipid-encapsulated resveratrol operates through a magnetron and can generate microwaves to act on the residual polar molecules (such as unfrozen water molecules) in the cell phospholipid-encapsulated resveratrol. Heat is generated through molecular rotation and friction, which directly heats the ice crystal core and increases the drying efficiency of cell phospholipid-encapsulated resveratrol. Attached Figure Description
[0025] Figure 1 This is a schematic diagram of the overall structure proposed in this utility model;
[0026] Figure 2 This is a first-view sectional view of the internal structure proposed in this utility model;
[0027] Figure 3 This is a second-view sectional view of the internal structure proposed in this utility model;
[0028] Figure 4 This is a third-view sectional view of the internal structure proposed in this utility model.
[0029] Legend:
[0030] 1. Outer shell; 2. Inner liner; 3. Cooling pipe; 4. Through hole; 5. First motor; 6. First shaft; 7. Fan blade; 8. Magnetron; 9. Base; 10. Second motor; 11. Second shaft; 12. Placement rack; 13. Negative pressure pump; 14. Air extraction pipe; 15. Door; 16. Temperature detector; 17. Display. Detailed Implementation
[0031] Reference Figure 1-4 This invention provides a vacuum gradient drying device for phospholipid-encapsulated resveratrol: It includes an outer shell 1, with an inner liner 2 fixedly connected inside the outer shell 1. A cooling pipe 3 is fixedly connected to the left side wall of the inner liner 2. The cooling pipe 3 has a corrugated structure and contains coolant. The corrugated structure of the cooling pipe 3 increases the contact area between the cooling pipe 3 and the inner liner 2. Cooling is achieved by the flow of coolant within the cooling pipe 3. The coolant can be silicone oil. Both the inlet and outlet ports of the cooling pipe 3 extend to the outside of the outer shell 1. Coolant is continuously injected into the cooling pipe 3, absorbing heat from the outer shell 1 and the inner liner 2, thus lowering the temperature of the phospholipid-encapsulated resveratrol inside the inner liner 2. This causes the internal water to freeze into ice crystals. After the ice crystals sublimate, the drying of the phospholipid-encapsulated resveratrol is completed. Furthermore, changing the flow rate and volume of the coolant within the cooling pipe 3 can adjust the temperature inside the inner liner 2. A cooling pipe is located on the back of the inner liner 2. There are multiple through holes 4. A magnetron 8 is fixedly connected to the right side wall of the inner liner 2. The magnetron 8 can be a Muegge MGM-20KW-2450. When the magnetron 8 is working, it can generate microwaves to act on the polar molecules such as unfrozen water molecules remaining in the cell phospholipid-encapsulated resveratrol. Heat is generated by molecular rotation and friction, which directly heats the ice crystal core and increases the drying efficiency of cell phospholipid-encapsulated resveratrol. A negative pressure pump 13 is fixedly connected to the top of the outer shell 1. An air extraction pipe 14 is fixedly connected to the input end of the negative pressure pump 13. The end of the air extraction pipe 14 away from the negative pressure pump 13 extends into the interior of the inner liner 2. Turning on the negative pressure pump 13 can extract the air inside the inner liner 2, so that the inner liner 2 is in a negative pressure state, which is conducive to the vacuum drying of cell phospholipid-encapsulated resveratrol. Changing the working efficiency of the negative pressure pump 13 can adjust the negative pressure state inside the inner liner 2, which is convenient for gradually reducing the air pressure in the inner liner 2. A door 15 is installed on the front of the inner liner 2.
[0032] A first motor 5 is fixedly connected to the inner wall of the left side of the outer shell 1. A first rotating shaft 6 is fixedly connected to the output end of the first motor 5. A fan blade 7 is fixedly connected to the end of the first rotating shaft 6 away from the first motor 5. The fan blade 7 is rotated by the operation of the first motor 5, which can diffuse the cold air around the cooling pipe 3 into the inner liner 2, which is conducive to reducing the temperature of resveratrol encapsulated by cell phospholipids.
[0033] A base 9 is fixedly connected to the bottom of the outer shell 1. A second motor 10 is fixedly connected inside the base 9. A second rotating shaft 11 is fixedly connected to the output end of the second motor 10. A placement rack 12 is fixedly connected to the end of the second rotating shaft 11 away from the second motor 10. The placement rack 12 is located inside the inner liner 2. When in use, cell phospholipid-encapsulated resveratrol is placed on the placement rack 12. The second motor 10 drives the placement rack 12 to rotate, which facilitates uniform cooling of cell phospholipid-encapsulated resveratrol and uniform microwave heating.
[0034] A temperature detector 16 is fixedly connected inside the door body 15. The temperature detector 16 can be of model FISO FOT-L-BA, which is resistant to electromagnetic interference and suitable for use in microwave systems. The temperature detector 16 is located inside the inner liner 2 and detects the temperature inside the inner liner 2. A display 17 is fixedly connected to the front of the door body 15 and displays the value detected by the temperature detector 16.
[0035] Working principle: During use, the phospholipid-encapsulated resveratrol to be dried is placed into the inner liner 2. Coolant is continuously injected into the cooling pipe 3. The coolant absorbs heat from the outer shell 1 and the interior of the inner liner 2, lowering the temperature of the phospholipid-encapsulated resveratrol inside the inner liner 2, causing the internal water to freeze into ice crystals. After the ice crystals sublimate, the drying of the phospholipid-encapsulated resveratrol is completed. Furthermore, changing the flow rate and volume of the coolant in the cooling pipe 3 can adjust the internal temperature of the inner liner 2, facilitating gradient cooling. Simultaneously, a negative pressure system is activated. The pressure pump 13 can extract air from the inside of the inner liner 2, making the inner liner 2 under negative pressure. This is beneficial for the vacuum drying of resveratrol encapsulated in cell phospholipids. Changing the working efficiency of the negative pressure pump 13 can adjust the negative pressure state inside the inner liner 2, making it easier to gradually reduce the air pressure inside the inner liner 2. Through the operation of the magnetron 8, microwaves can be generated to act on the residual polar molecules (such as unfrozen water molecules) in the resveratrol encapsulated in cell phospholipids. Heat is generated through molecular rotation and friction, which directly heats the ice crystal core and increases the drying efficiency of resveratrol encapsulated in cell phospholipids.
[0036] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A vacuum gradient drying device for encapsulating resveratrol in cell phospholipids, comprising a shell (1), characterized in that: The inner liner (2) is fixedly connected inside the outer shell (1). A cooling pipe (3) is fixedly connected to the left side wall of the inner liner (2). The inlet and outlet ports of the cooling pipe (3) extend to the outside of the outer shell (1). A through hole (4) is opened on the back of the inner liner (2), and there are multiple through holes (4). A magnetron (8) is fixedly connected to the right side wall of the inner liner (2). A negative pressure pump (13) is fixedly connected to the top of the outer shell (1). An air extraction pipe (14) is fixedly connected to the input end of the negative pressure pump (13). The end of the air extraction pipe (14) away from the negative pressure pump (13) extends into the interior of the inner liner (2). A door (15) is installed on the front of the inner liner (2).
2. The vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids according to claim 1, characterized in that: A first motor (5) is fixedly connected to the inner left side of the outer casing (1). A first rotating shaft (6) is fixedly connected to the output end of the first motor (5). A fan blade (7) is fixedly connected to the end of the first rotating shaft (6) away from the first motor (5).
3. The vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids according to claim 1, characterized in that: The bottom of the outer shell (1) is fixedly connected to a base (9), and a second motor (10) is fixedly connected inside the base (9). The output end of the second motor (10) is fixedly connected to a second rotating shaft (11), and a placement rack (12) is fixedly connected to the end of the second rotating shaft (11) away from the second motor (10). The placement rack (12) is located inside the inner liner (2).
4. The vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids according to claim 1, characterized in that: A temperature detector (16) is fixedly connected inside the door (15), and the temperature detector (16) is located inside the inner liner (2).
5. The vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids according to claim 1, characterized in that: A display (17) is fixedly connected to the front of the door (15).
6. The vacuum gradient drying device for encapsulating resveratrol with cellular phospholipids according to claim 1, characterized in that: The cooling pipe (3) has a corrugated structure and is filled with coolant.