Serum detection equipment for early screening of gastric cancer

Abstract

The utility model belongs to the technical field of serum detection equipment, and particularly relates to serum detection equipment for gastric cancer early screening, which comprises a detection box, a treatment groove and a detection groove are formed in the detection box, a treatment mechanism comprises a treatment box and a pick-and-place assembly, and an extractor and a dilution tube are fixed at the output end of the pick-and-place assembly; the detection mechanism comprises a driving motor, a driving screw rod and a lifting plate, a plurality of placement grooves are formed in the top of the lifting plate, and detection plates are detachably connected into the placement grooves; serum is placed in the treatment box and diluted through the dilution pipe, then the taking and placing assembly drives the suction device to extract a sample, the serum is dropped into the detection hole in the detection plate, the lifting plate and the detection plate are driven by the driving motor to move to a detection area, and the detection area is detected. The detection box is used for detecting pepsinogen I (PGI), pepsinogen II (PGII) and the ratio of PGI to PGII in serum through a chemiluminescence method.

Description

Technical Field

[0001] This invention belongs to the technical field of serum testing equipment, specifically relating to a serum testing device for early screening of gastric cancer. Background Technology

[0002] Gastric cancer is a common and highly lethal malignant tumor, ranking second in mortality among cancers. The early diagnosis rate and 5-year survival rate for advanced gastric cancer are both less than 20%. Currently, widely used detection methods for gastric cancer include non-invasive examinations (such as ultrasound and CT scans) and invasive examinations (gastroscopy and barium meal), but these lack adherence and widespread application. Therefore, new biomarkers, especially serum molecular markers, are needed for timely detection of gastric cancer, enabling patients to receive timely and effective early diagnosis and treatment. This is crucial for improving the survival rate and reducing the mortality rate of gastric cancer patients.

[0003] Traditional gastric cancer screening methods, such as gastroscopy, while accurate, are invasive, costly, and have low patient acceptance. Existing serum testing equipment cannot effectively pre-process serum, requiring manual dilution, re-mixing, and finally, dropping the serum onto an antibody-containing test plate. Chemiluminescence is then generated by adding a chemiluminescent substrate. This cumbersome process can lead to inconsistent measurement results, hindering accurate screening and diagnosis of early-stage tumors. Utility Model Content

[0004] The purpose of this invention is to provide a serum testing device for early screening of gastric cancer, which can improve testing efficiency, reduce sample processing time, and precisely control the amount of diluent added to ensure that a uniform standard concentration of serum sample is obtained, thereby improving the reliability and accuracy of the test.

[0005] The specific technical solution adopted by this utility model is as follows:

[0006] A serum testing device for early screening of gastric cancer includes a testing chamber, wherein the testing chamber has a processing tank and a testing tank inside, and one side of the processing tank is connected to the side of the testing tank adjacent to it.

[0007] The processing mechanism includes a processing box and a pick-and-place component. The processing box is slidably connected to the bottom of the processing tank. The pick-and-place component is slidably disposed above the processing box. The output end of the pick-and-place component is fixed with a suction device and a dilution tube. The output end of the suction device is detachably connected with a suction tube.

[0008] The testing mechanism includes a drive motor, which is fixed to the bottom of the testing groove. The output shaft of the drive motor is fixedly connected to one end of a drive screw. The drive screw is threadedly connected to one end of a lifting plate. The other end of the lifting plate is slidably connected to the inside of the testing groove. The top of the lifting plate is provided with multiple placement slots, and each of the multiple placement slots can be detachably connected to a testing plate.

[0009] The process involves placing serum inside a processing box, diluting the serum using a dilution tube, then using a pick-and-place assembly to extract the sample from the aspirator and drop the serum into the detection holes on the detection plate. A drive motor then moves the lifting plate and the detection plate to the detection area, allowing the detection chamber to detect pepsinogen I (PGI), pepsinogen II (PGII), and the PGI / PGII ratio in the serum using chemiluminescence immunoassay.

[0010] Furthermore, a guide rod is fixed to the bottom of the processing tank, and the processing box is slidably connected above the guide rod.

[0011] Furthermore, a sliding groove is provided at the bottom of the processing box, and the sliding groove is slidably connected to the guide rod.

[0012] Furthermore, a vibrating shaker is fixed inside the processing box, and a fixed inner box is fixed to the output end of the vibrating shaker.

[0013] Furthermore, the interior of the fixed inner box is provided with multiple fixing slots, and each of the multiple fixing slots is provided with a protective pad, which is made of rubber.

[0014] Furthermore, the pick-and-place assembly includes an axial guide rail, with both ends of the axial guide rail fixedly connected to one side of the processing groove and one side of the detection groove, respectively, and an axial driver slidably connected to the bottom of the axial guide rail.

[0015] Furthermore, one side of the axial driver is fixedly connected to one end of the adjusting guide rail, the other end of the adjusting guide rail is slidably connected to the inside of the detection box, an adjuster is slidably connected below the adjusting guide rail, a lifter is fixedly attached to the bottom of the adjuster, and the output shaft of the lifter is fixedly connected to the suction device and the dilution tube respectively.

[0016] Furthermore, control buttons and a display screen are fixed to the outside of the detection box.

[0017] The technical effects achieved by this utility model are as follows:

[0018] This invention relates to a serum testing device for early screening of gastric cancer. By placing multiple serum samples in a fixed inner box, the device can improve testing efficiency and reduce sample processing time. Simultaneously, by precisely controlling the amount of diluent added, a uniform standard concentration of serum samples is ensured, which helps improve the reliability and accuracy of the test. Fixing the inner box to the output end of a shaker and controlling the shaking time effectively achieves uniform mixing of samples, ensuring even distribution of each sample. Differentiating and testing multiple samples effectively improves testing efficiency and accuracy.

[0019] This invention relates to a serum testing device for early screening of gastric cancer. By incorporating a detachable aspiration tube at the output end of the aspirator, the tube can be quickly replaced after testing a sample, improving testing efficiency and reducing the risk of cross-contamination. Simultaneously, the testing mechanism provides stable support for the testing plate, ensuring thorough contact between the plate and the serum sample, thus enhancing accuracy and minimizing errors. Furthermore, precise control of the testing plate's movement effectively moves the serum sample to the testing area, reducing errors caused by human error and further improving overall testing efficiency. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of this practical application;

[0021] Figure 2 This is a partial sectional view of the overall structure of this utility model;

[0022] Figure 3 This is a schematic diagram of the internal structure adjustment of this practical tool;

[0023] Figure 4 This is a partial exploded view of the internal structure of this utility model.

[0024] The attached diagram lists the components represented by each number as follows:

[0025] 10. Detection box; 11. Processing tank; 111. Guide rod; 12. Detection tank; 20. Processing mechanism; 21. Processing box; 211. Sliding groove; 212. Vibrating shaker; 213. Fixed inner box; 22. Pick-up and drop assembly; 221. Axial guide rail; 222. Axial drive; 223. Adjusting guide rail; 224. Adjuster; 225. Lifter; 23. Suction device; 24. Dilution tube; 30. Detection mechanism; 31. Drive motor; 32. Drive screw; 33. Lifting plate; 34. Detection plate. Detailed Implementation

[0026] To make the objectives and advantages of this utility model clearer, the following detailed description is provided in conjunction with embodiments. It should be understood that the following text is merely used to describe one or more specific implementations of this utility model and does not strictly limit the scope of protection specifically claimed by this utility model.

[0027] like Figures 1 to 4 As shown, a serum testing device for early screening of gastric cancer includes a testing box 10. The testing box 10 has a processing tank 11 and a testing tank 12 inside. One side of the processing tank 11 is connected to the side of the testing tank 12 adjacent to each other.

[0028] The processing mechanism 20 includes a processing box 21 and a pick-and-place component 22. The processing box 21 is slidably connected to the bottom of the processing tank 11. The pick-and-place component 22 is slidably disposed above the processing box 21. The output end of the pick-and-place component 22 is fixed with a suction device 23 and a dilution tube 24. The output end of the suction device 23 is detachably connected with a suction tube.

[0029] The detection mechanism 30 includes a drive motor 31, which is fixed to the bottom of the detection groove 12. The output shaft of the drive motor 31 is fixedly connected to one end of the drive screw 32. The drive screw 32 is threadedly connected to one end of the lifting plate 33. The other end of the lifting plate 33 is slidably connected to the inside of the detection groove 12. The top of the lifting plate 33 is provided with multiple placement slots, and each of the multiple placement slots can be detachably connected to a detection plate 34.

[0030] In this embodiment, it should be noted that a chemiluminescence detector is fixed inside the detection box 10 for detecting the serum on the detection plate 34, effectively analyzing the pepsin content in the serum. This is a conventional technique in the art and will not be elaborated further here. The processing mechanism 20 effectively dilutes the serum while simultaneously shaking and mixing the diluted serum evenly. Specifically, the serum is placed in the processing box 21, and then the dilution tube 24 is moved above the processing box 21 by the pick-and-place assembly 22. It should be noted that the other end of the dilution tube 24 is connected to the diluent, which is used to transfer the diluent into the serum. The serum is then uniformly mixed using the processing box 21. The diluted serum is then drawn up by the aspirator 23 and moved above the detection mechanism 30 by the pick-and-place assembly 22. The serum is then dropped onto the detection plate 34. The drive motor 31 drives the drive screw 32 to rotate. Through the threaded action between the drive screw 32 and the lifting plate 33, the lifting plate 33 rises and falls. The lifting plate 33 then moves the detection plate 34 above it to the detection area, allowing the detection chamber 10 to detect pepsinogen I (PGI), pepsinogen I (IPGII), and the PGI / PGII ratio in the serum using a chemiluminescence detector. Specifically, after serum testing is completed, the aspirator tube can be replaced for repeated testing, effectively improving testing efficiency.

[0031] like Figure 4 As shown, a guide rod 111 is fixed at the bottom of the processing tank 11, and a processing box 21 is slidably connected above the guide rod 111; wherein, the guide rod 111 can accurately guide the movement of the processing box 21, ensuring that the dilution and loading / unloading work is carried out effectively.

[0032] Preferably, the bottom of the processing box 21 is provided with a sliding groove 211. By sliding the sliding groove 211 to the guide rod 111, the stable movement of the processing box 21 can be ensured, thereby driving the serum in the processing box 21 to move into the processing tank 11 for dilution and detection.

[0033] like Figure 4 As shown, a shaker 212 is fixed inside the processing box 21 to generate shaking and oscillation forces; a fixed inner box 213 is fixed through the output end of the shaker 212 to ensure that the serum in the fixed inner box 213 is mixed with the diluent and then shaken evenly to form a sample of appropriate concentration for testing.

[0034] Preferably, the inner box 213 has multiple fixing slots inside, and each fixing slot has a protective pad made of rubber.

[0035] In this embodiment, it should be noted that by fixing multiple sample containers in multiple slots, it is convenient to perform multiple tests on multiple samples, ensuring the accuracy of the test. By setting a protective pad inside the fixing slot, the sample storage containers can be protected, preventing damage to the containers and reducing the risk of sample contamination. When the processing box 21 moves into the processing slot 11, the pick-and-place component 22 moves the dilution tube 24 above the processing box 21, and accurately adds diluent to the multiple serum samples in the fixed inner box 213. By activating the shaking shaker 212 to generate a shaking force, the fixed inner box 213 and the serum samples are shaken to ensure that the sample concentration meets the detection concentration.

[0036] like Figure 2 , Figure 4 As shown, the pick-and-place assembly 22 includes an axial guide rail 221, which provides guidance for the precise movement of the pick-and-place assembly 22. By fixing both ends of the axial guide rail 221 to one side of the processing tank 11 and one side of the detection tank 12 respectively, the stability of the axial guide rail 221 during use is ensured. An axial driver 222 is slidably connected to the bottom of the axial guide rail 221. It should be noted that the axial driver 222 is a driving element. When the axial driver 222 is working, it effectively cooperates with the axial guide rail 221, thereby moving precisely at the bottom of the axial guide rail 221. The use of the axial driver 222 is a conventional technical means, and will not be described in detail here.

[0037] Preferably, one side of the axial drive 222 is fixedly connected to one end of the adjusting guide rail 223, the other end of the adjusting guide rail 223 is slidably connected to the inside of the detection box 10, the adjusting guide rail 223 is slidably connected to the lower part of the adjusting guide rail 223, the bottom of the adjusting guide rail 224 is fixedly equipped with a lifter 225, and the output shaft of the lifter 225 is fixedly connected to the suction device 23 and the dilution tube 24 respectively.

[0038] In this embodiment, based on the previous embodiment, when the processing box 21 carrying serum moves into the processing tank 11, the axial drive 222 is activated to effectively cooperate with the axial guide rail 221, driving the axial drive 222 and the adjusting guide rail 223 to move and adjust inside the processing tank 11 and the detection tank 12; when the adjusting guide rail 223 moves above the processing box 21, the regulator 224 is activated to cooperate with the adjusting guide rail 223, driving the aspirator 23 and the dilution tube 24 fixedly connected to the bottom of the regulator 224 to move precisely above the sample fixed inside the processing box 21; Subsequently, the lifting device 225 drives the dilution tube 24 to add diluent to multiple samples inside the fixed inner box 213. Then, the shaking device 212 drives the fixed inner box 213 to shake the samples. The lifting device 225 drives the aspirator 23 to aspirate the samples. After aspiration, the pick-and-place component 22 drives the aspirator 23 to move precisely above the detection plate 34. The serum sample in the aspirator 23 is dripped into the detection hole opened above the detection plate 34. Then, the lifting plate 33 drives the detection plate 34 to move to the detection area, effectively detecting the serum.

[0039] Preferably, the test chamber 10 is equipped with control buttons and a display screen on its outer side. The control buttons can effectively control the amount of diluent added and the working time of the shaker 212. The display screen can accurately record the test results and the number of tests, so as to facilitate the collection and recording of test data by personnel.

[0040] The working principle of this utility model is as follows: When serum needs to be tested, the serum container is placed in the fixed slot of the fixed inner box 213. Then, the fixed inner box 213 is moved into the processing slot 11 by the processing box 21. At this time, the pick-and-place component 22 moves in multiple directions within the internal space of the detection chamber 10, moving the dilution tube 24 fixedly connected to its bottom above the sample, and then adding a standard quantitative diluent to the serum. At this time, the shaking and mixing device 212 inside the processing box 21 is activated, which in turn drives the fixed inner box 213 at its output end to shake and mix the serum in the fixed slot. After dilution is completed, the sample serum is drawn by activating the aspirator 23. Then, the aspirator is drawn by activating the pick-and-place component 22. 23 moves above the detection plate 34 and adds the sample serum into the detection hole of the detection plate 34; then, by starting the drive motor 31, the drive screw 32 is driven to interact with the lifting plate 33, thereby moving the lifting plate 33 to the top of the detection slot 12. The sample is then subjected to chemiluminescence detection by the luminescence detector set in the detection box 10, thereby determining the pepsinogen I (PGI), pepsinogen II (PGII) and the PGI / PGII ratio in the serum, and thus determining whether the sample has the risk of gastric cancer. The specific principle of the measurement and the selection of reagents are not the technical points of this application. Therefore, it is only necessary to use the relatively mature technology currently on the market, so it will not be described in detail here.

[0041] The above description is merely a preferred embodiment of this utility model. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of this utility model, and these improvements and modifications should also be considered within the scope of protection of this utility model. Structures, devices, and operating methods not specifically described or explained in this utility model, unless otherwise specified or limited, shall be implemented using conventional methods in the field.

Claims

1. A serum detection device for early screening of gastric cancer, characterized in that: The test box (10) includes a processing slot (11) and a test slot (12) inside the test box (10). One side of the processing slot (11) is connected to the side of the test slot (12) adjacent to it. The processing mechanism (20) includes a processing box (21) and a pick-and-place assembly (22). The processing box (21) is slidably connected to the bottom of the processing tank (11). The pick-and-place assembly (22) is slidably disposed above the processing box (21). The output end of the pick-and-place assembly (22) is fixed with a suction device (23) and a dilution tube (24). The output end of the suction device (23) is detachably connected with a suction tube. The detection mechanism (30) includes a drive motor (31), which is fixed to the bottom of the detection groove (12). The output shaft of the drive motor (31) is fixedly connected to one end of the drive screw (32). The drive screw (32) is threadedly connected to one end of the lifting plate (33). The other end of the lifting plate (33) is slidably connected to the inside of the detection groove (12). The top of the lifting plate (33) is provided with multiple placement slots, and each of the multiple placement slots can be detachably connected to a detection plate (34). In this process, the serum is placed inside the processing box (21) and diluted using the dilution tube (24). Then, the sample is extracted by the pick-and-place assembly (22) driving the aspirator (23) and the serum is dropped into the detection hole on the detection plate (34). The lifting plate (33) and the detection plate (34) are moved to the detection area by the drive motor (31), so that the detection box (10) can detect pepsinogen I (PGI), pepsinogen II (PGII) and the PGI / PGII ratio in the serum by chemiluminescence method.

2. The serum detection device for early screening of gastric cancer according to claim 1, characterized in that: The bottom of the processing tank (11) is fixed with a guide rod (111), and the processing box (21) is slidably connected above the guide rod (111).

3. A serum detection device for early screening of gastric cancer according to claim 2, characterized in that: The bottom of the processing box (21) is provided with a sliding groove (211), and the sliding groove (211) is slidably connected to the guide rod (111).

4. A serum detection device for early screening of gastric cancer according to claim 1, characterized in that: The processing box (21) is equipped with a shaking shaker (212) inside, and the output end of the shaking shaker (212) is equipped with a fixed inner box (213).

5. A serum detection device for early screening of gastric cancer according to claim 4, characterized in that: The fixed inner box (213) has multiple fixing slots inside, and each of the multiple fixing slots has a protective pad inside, which is made of rubber.

6. A serum detection device for early screening of gastric cancer according to claim 1, characterized in that: The pick-and-place assembly (22) includes an axial guide rail (221), the two ends of which are fixedly connected to one side of the processing groove (11) and one side of the detection groove (12), respectively, and an axial driver (222) is slidably connected to the bottom of the axial guide rail (221).

7. A serum detection device for early screening of gastric cancer according to claim 6, characterized in that: One side of the axial drive (222) is fixedly connected to one end of the adjusting guide rail (223), and the other end of the adjusting guide rail (223) is slidably connected to the inside of the detection box (10). The adjusting guide rail (223) is slidably connected to the lower part of the adjusting guide rail (224), and the bottom of the adjusting guide rail (224) is fixedly connected to the lifting device (225). The output shaft of the lifting device (225) is fixedly connected to the suction device (23) and the dilution tube (24) respectively.

8. A serum detection device for early screening of gastric cancer according to claim 1, characterized in that: The detection box (10) is equipped with control buttons and a display screen on its outer side.

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