Purification device for production of medical intermediates

Abstract

The utility model relates to a purification device for production of medical intermediates, which comprises a tank body, the top of the tank body is communicated with a feed pipe, the bottom of the tank body is communicated with a discharge pipe, the tank body is provided with a stirring mechanism, the bottom of the discharge pipe is communicated with a purification mechanism, the bottom of the purification mechanism is communicated with a blanking pipe, and the blanking pipe is communicated with the discharge pipe. And valves are fixedly mounted at the outer part of the feeding pipe, the outer part of the discharging pipe and the outer part of the blanking pipe. According to the purification device for medical intermediate production, the feeding pipe is opened firstly, medical intermediate raw materials are poured into the feeding pipe, then the stirring mechanism is used for stirring the medical intermediate raw materials, after stirring is completed, the stirring mechanism is closed, the discharging pipe is opened, and then the purification mechanism is used for purifying the stirred medical intermediate raw materials; and finally, the discharging pipe is opened, purified medical intermediate raw materials are collected, the purification mechanism is convenient to directly replace, operation is easy, time and labor are saved, and the using effect is improved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical intermediate production technology, specifically a purification device for pharmaceutical intermediate production. Background Technology

[0002] Pharmaceutical intermediates are actually chemical raw materials or products used in the process of drug synthesis. Pharmaceutical intermediates are produced through rough processing and contain a large number of impurities. They cannot be used directly in the production of drugs and need to be purified.

[0003] According to Chinese utility model application number CN202321234552.X, a purification device for pharmaceutical intermediates is proposed. The utility model describes that "the purification device can be disassembled by simply pressing the push block to separate the card block from the card slot and release the fixation. Compared with the existing device, the disassembly process is simpler and the device is more convenient to use."

[0004] The current pharmaceutical intermediate purification device has an adsorption layer installed inside the tank. Operators need to open the lid first and then replace the adsorption layer, which is cumbersome, time-consuming, and labor-intensive, affecting the effectiveness of the device. Therefore, an improvement is needed. This paper proposes a purification device for pharmaceutical intermediate production to solve the above problems. Utility Model Content

[0005] To address the shortcomings of existing technologies, this utility model provides a purification device for the production of pharmaceutical intermediates, which has advantages such as good performance. It solves the problem that it is cumbersome, time-consuming, and labor-intensive for operators to open the lid and replace the adsorption layer, thus affecting the effectiveness of the device.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a purification device for the production of pharmaceutical intermediates, comprising a tank, an inlet pipe connected to the top of the tank, an outlet pipe connected to the bottom of the tank, a stirring mechanism provided on the tank, a purification mechanism connected to the bottom of the outlet pipe, a discharge pipe connected to the bottom of the purification mechanism, and valves fixedly installed on the outside of the inlet pipe, the outside of the outlet pipe, and the outside of the discharge pipe;

[0007] The purification mechanism includes a chamber, with an outlet pipe connected to the top of the chamber and a discharge pipe connected to the bottom of the chamber. Two horizontal plates are inserted into the side wall of the chamber, with the outer sides of the two horizontal plates fitting against the inner side wall of the chamber. A filter screen and an activated carbon filter screen are respectively embedded inside the two horizontal plates, with the filter screen located above the activated carbon filter screen. A vertical plate and a sealing gasket are fixedly installed on the outside of each of the two horizontal plates, with the sealing gasket located between the vertical plate and the chamber. A horizontal bar is rotatably installed on the outer side wall of the chamber, with a limit plate fixedly installed at the end of the horizontal bar away from the outer side wall of the chamber. An anti-slip pad that fits against the vertical plate is fixedly installed on the side wall of the limit plate.

[0008] Furthermore, the tank body includes a tank body and a tank cover. The tank cover is threadedly connected to the tank body by a first bolt. The feed pipe is connected to the top of the tank cover, and the discharge pipe is connected to the bottom of the tank body.

[0009] Furthermore, the stirring mechanism includes a motor, which is fixedly connected to the top of the tank. The output end of the motor passes through the tank and is fixedly mounted with a rotating shaft. A stirring frame is fixedly mounted on the outside of the rotating shaft. A cleaning plate is detachably mounted on the side wall of the stirring frame, and the side wall of the cleaning plate is in contact with the inner side wall of the tank.

[0010] Furthermore, the cleaning plate is threadedly connected to the mixing frame by a second bolt, and the cleaning plate is made of rubber.

[0011] Furthermore, handles are fixedly installed on the exterior of both vertical plates, and anti-slip textures are provided on the side walls of both vertical plates.

[0012] Furthermore, the crossbar is rotatably connected to the chamber body via a bearing, and the crossbar is located between two vertical plates.

[0013] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0014] This purification device for pharmaceutical intermediate production consists of a tank, a feed pipe, a discharge pipe, a stirring mechanism, a purification mechanism, and a feed pipe. First, the feed pipe is opened, and the pharmaceutical intermediate raw material is poured into it. Then, the stirring mechanism is used to stir the raw material. After stirring, the stirring mechanism is closed, and the discharge pipe is opened. Next, the purification mechanism is used to purify the stirred pharmaceutical intermediate raw material. Finally, the feed pipe is opened, and the purified pharmaceutical intermediate raw material is collected. The purification mechanism is easy to replace, making the operation simple, time-saving, and labor-saving, thus improving the efficiency of use. Attached Figure Description

[0015] Figure 1 This is a front view of the present utility model;

[0016] Figure 2This is a schematic diagram of the stirring mechanism of this utility model;

[0017] Figure 3 This is a schematic diagram of the purification mechanism of this utility model;

[0018] Figure 4 This utility model Figure 3 Enlarged view of point A in the middle;

[0019] Figure 5 This utility model Figure 3 Enlarged view at point B in the middle;

[0020] Figure 6 This is a schematic diagram of the horizontal plate structure of this utility model.

[0021] In the diagram: 1. Tank body, 2. Inlet pipe, 3. Outlet pipe, 4. Stirring mechanism, 41. Motor, 42. Rotary shaft, 43. Stirring frame, 44. Cleaning plate, 5. Purification mechanism, 51. Chamber body, 52. Horizontal plate, 53. Filter screen, 54. Activated carbon filter screen, 55. Vertical plate, 56. Sealing gasket, 57. Horizontal bar, 58. Limiting plate, 59. Anti-slip pad, 6. Discharge pipe. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figure 1-6 The purification device for producing pharmaceutical intermediates in this embodiment includes a tank 1, with a feed pipe 2 connected to the top of the tank 1 and a discharge pipe 3 connected to the bottom of the tank 1. A stirring mechanism 4 is provided on the tank 1, and a purification mechanism 5 is connected to the bottom of the discharge pipe 3. A discharge pipe 6 is connected to the bottom of the purification mechanism 5. Valves are fixedly installed on the outside of the feed pipe 2, the outside of the discharge pipe 3, and the outside of the discharge pipe 6.

[0024] Specifically, the staff first opens the feed pipe 2 and pours the pharmaceutical intermediate raw material into the feed pipe 2. Then, the stirring mechanism 4 is used to stir the pharmaceutical intermediate raw material. After stirring, the stirring mechanism 4 is closed and the discharge pipe 3 is opened. Then, the purification mechanism 5 is used to purify the stirred pharmaceutical intermediate raw material. Finally, the discharge pipe 6 is opened and the purified pharmaceutical intermediate raw material is collected. The purification mechanism 5 is easy to replace directly, the operation is relatively simple, time-saving and labor-saving, and the use effect is improved.

[0025] In this embodiment, the tank body 1 includes a tank body and a tank cover. The tank cover is threadedly connected to the tank body by a first bolt. The first bolt is a plurality of bolts and is evenly distributed in a ring. The feed pipe 2 is connected to the top of the tank cover, and the discharge pipe 3 is connected to the bottom of the tank body.

[0026] Specifically, by unscrewing the first bolt from the inside of the can body and the lid, the lid can be removed from the top of the can body.

[0027] In this embodiment, the stirring mechanism 4 includes a motor 41, which is fixedly connected to the top of the tank. The output end of the motor 41 passes through the tank 1 and is fixedly mounted with a rotating shaft 42. A stirring frame 43 is fixedly mounted on the outside of the rotating shaft 42. There are multiple stirring frames 43, which are evenly and equidistantly distributed in a ring. The stirring frame 43 has through holes inside, which are evenly and equidistantly distributed. A cleaning plate 44 is detachably mounted on the side wall of the stirring frame 43. The cleaning plate 44 is threadedly connected to the stirring frame 43 by a second bolt, which is evenly and equidistantly distributed. The cleaning plate 44 is made of rubber, and the side wall of the cleaning plate 44 is in contact with the inner side wall of the tank.

[0028] Specifically, by turning on the motor 41, the motor 41 drives the rotating shaft 42, the stirring frame 43 and the cleaning plate 44 to rotate. The stirring frame 43 stirs the pharmaceutical intermediate raw materials, and the cleaning plate 44 cleans the inner wall of the tank.

[0029] In this embodiment, the purification mechanism 5 includes a chamber 51, an outlet pipe 3 connected to the top of the chamber 51, and a discharge pipe 6 connected to the bottom of the chamber 51. Two horizontal plates 52 are inserted into the side wall of the chamber 51, and the outer sides of the two horizontal plates 52 are in contact with the inner side wall of the chamber 51. A filter screen 53 and an activated carbon filter screen 54 are respectively embedded inside the two horizontal plates 52, with the filter screen 53 located above the activated carbon filter screen 54. Vertical plates 55 and sealing gaskets 56 are fixedly installed on the outside of each of the two horizontal plates 52. The sealing gaskets 56 are positioned... Between the vertical plate 55 and the hopper body 51, a crossbar 57 is rotatably installed on the outer wall of the hopper body 51. The crossbar 57 is rotatably connected to the hopper body 51 through a bearing. The crossbar 57 is located between the two vertical plates 55. A limit plate 58 is fixedly installed at the end of the crossbar 57 away from the outer wall of the hopper body 51. An anti-slip pad 59 that fits against the vertical plate 55 is fixedly installed on the side wall of the limit plate 58. Both anti-slip pads 59 are made of rubber. A handle is fixedly installed on the outside of both vertical plates 55. Anti-slip textures are opened on the side walls of both vertical plates 55.

[0030] In addition, the two horizontal plates 52 form a group, and the interior of the two horizontal plates 52 is respectively equipped with a filter screen 53 and an activated carbon filter screen 54. Four sets can be inserted into the four side walls of the chamber body 51. The four sets are distributed in a cross pattern, which can not only improve the purification effect, but also allow for replacement during the purification process.

[0031] Specifically, first rotate the limiting plate 58, which causes the two anti-slip pads 59 to rotate 90°, separating them from the two vertical plates 55. Then pull the two handles, which move the two horizontal plates 52 out of the chamber 51, allowing the filter screen 53 and activated carbon filter screen 54 to be disassembled. Next, push the two handles, which insert the two horizontal plates 52 into the chamber 51. Finally, rotate the limiting plate 58, which causes the two anti-slip pads 59 to rotate 90°, making them fit against the two vertical plates 55, allowing the filter screen 53 and activated carbon filter screen 54 to be installed. This facilitates direct replacement and is a relatively simple operation.

[0032] The working principle of the above embodiments is as follows:

[0033] First, open the feed pipe 2 and pour the pharmaceutical intermediate raw material into it. Then, turn on the motor 41. The motor 41 drives the rotating shaft 42, stirring frame 43, and cleaning plate 44 to rotate. The stirring frame 43 stirs the pharmaceutical intermediate raw material, and the cleaning plate 44 cleans the inner wall of the tank. After stirring, turn off the motor 41 and open the discharge pipe 3. The filter screen 53 and activated carbon filter screen 54 purify the stirred pharmaceutical intermediate raw material. Finally, open the discharge pipe 6 and collect the purified pharmaceutical intermediate raw material. During maintenance, first rotate the limit plate 58. The limit plate 58 drives the two anti-slip pads 59 to rotate. Rotate 90° to separate the two anti-slip pads 59 from the two vertical plates 55. Then pull the two handles, which will move the two horizontal plates 52 out of the chamber 51, allowing the filter screen 53 and activated carbon filter screen 54 to be disassembled. Push the two handles again, which will move the two horizontal plates 52 back into the chamber 51. Finally, rotate the limiting plate 58, which will rotate the two anti-slip pads 59 90° so that they fit against the two vertical plates 55, allowing the filter screen 53 and activated carbon filter screen 54 to be installed. This facilitates direct replacement and is simple to operate, saving time and effort and improving the performance.

[0034] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0035] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A purification apparatus for the production of pharmaceutical intermediates, comprising a tank (1), wherein the top of the tank (1) is connected to a feed pipe (2), the bottom of the tank (1) is connected to a discharge pipe (3), a stirring mechanism (4) is provided on the tank (1), the bottom of the discharge pipe (3) is connected to a purification mechanism (5), the bottom of the purification mechanism (5) is connected to a discharge pipe (6), and valves are fixedly installed on the outside of the feed pipe (2), the outside of the discharge pipe (3), and the outside of the discharge pipe (6), characterized in that: The purification mechanism (5) includes a chamber (51), the discharge pipe (3) is connected to the top of the chamber (51), and the discharge pipe (6) is connected to the bottom of the chamber (51). Two horizontal plates (52) are inserted into the side wall of the chamber (51). The outer side walls of the two horizontal plates (52) are in contact with the inner side wall of the chamber (51). A filter screen (53) and an activated carbon filter screen (54) are respectively embedded inside the two horizontal plates (52). The filter screen (53) is located in the activated carbon filter. Above the filter screen (54), vertical plates (55) and sealing gaskets (56) are fixedly installed on the outside of the two horizontal plates (52). The sealing gaskets (56) are located between the vertical plates (55) and the chamber (51). A horizontal bar (57) is rotatably installed on the outer wall of the chamber (51). A limiting plate (58) is fixedly installed at the end of the horizontal bar (57) away from the outer wall of the chamber (51). An anti-slip pad (59) that fits against the vertical plate (55) is fixedly installed on the side wall of the limiting plate (58).

2. The purification apparatus for producing pharmaceutical intermediates as described in claim 1, characterized in that: The tank body (1) includes a tank body and a tank cover. The tank cover is threadedly connected to the tank body by a first bolt. The feed pipe (2) is connected to the top of the tank cover, and the discharge pipe (3) is connected to the bottom of the tank body.

3. The purification apparatus for producing pharmaceutical intermediates as described in claim 2, characterized in that: The stirring mechanism (4) includes a motor (41), which is fixedly connected to the top of the tank. The output end of the motor (41) passes through the tank (1) and is fixedly installed with a rotating shaft (42). A stirring frame (43) is fixedly installed on the outside of the rotating shaft (42). A cleaning plate (44) is detachably installed on the side wall of the stirring frame (43). The side wall of the cleaning plate (44) is in contact with the inner side wall of the tank.

4. The purification apparatus for producing pharmaceutical intermediates as described in claim 3, characterized in that: The cleaning plate (44) is threadedly connected to the stirring frame (43) by a second bolt, and the cleaning plate (44) is made of rubber.

5. The purification apparatus for producing pharmaceutical intermediates as described in claim 1, characterized in that: Handles are fixedly installed on the outside of both vertical plates (55), and anti-slip textures are provided on the side walls of both vertical plates (55).

6. The purification apparatus for producing pharmaceutical intermediates as described in claim 1, characterized in that: The crossbar (57) is rotatably connected to the chamber body (51) via a bearing, and the crossbar (57) is located between two vertical plates (55).

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