A biological tissue homogenizer

Abstract

This utility model discloses a biological tissue homogenizer, specifically relating to the field of cell tissue homogenization technology. It includes a homogenization mechanism comprising a base and a support frame. A placement mechanism is slidably connected above the support frame, and a hydraulic cylinder is mounted above the support frame. This utility model achieves automatic cleaning and surface moisture adsorption of the homogenizing rod through the coordinated operation of the placement mechanism, cleaning mechanism, wiping mechanism, connecting rope, and water tank. The placement mechanism and cleaning mechanism are linked by guide wheels and slide rails, allowing for simultaneous placement and removal of the homogenizing tube, reset of the cleaning mechanism, and preparation for cleaning the homogenizing rod with a single pull, simplifying the operation process. The wiping components (door panel, absorbent cotton) employ an automatic reset design with torsion springs to ensure unobstructed movement of the homogenizing rod, and the absorbent cotton is periodically squeezed by a squeezing block to expel moisture, extending its service life.

Description

Technical Field

[0001] This utility model relates to the field of cell tissue homogenization technology, and in particular to a biological tissue homogenizer. Background Technology

[0002] A tissue homogenizer is a commonly used laboratory device, primarily used to uniformly break down or mix biological tissue or cell samples for subsequent extraction of nucleic acids, proteins, or other biomolecules. Its core principle is to disrupt cell structure through mechanical force (such as a high-speed rotating blade), releasing internal components. The device typically consists of a motor-driven mechanism, replaceable homogenizing heads (such as blades), and a matching container.

[0003] Patent CN222119244U discloses a cell tissue homogenizer, belonging to the field of cell tissue homogenization technology. This homogenizer includes a placement stage, with an electric push rod fixedly connected to its upper surface. A support plate is fixedly connected to the end of the electric push rod away from the placement stage. A support column is mounted inside the support plate via bearings. Gears are fixedly connected to the top of the support column, with two gears meshing close to each other. Multiple gears are present. The upper surface of one of the gears is fixedly connected to the output end of a servo motor. A mounting base is fixedly connected to the bottom of the support column, with a connector inserted inside. A tamping rod is fixedly connected to the lower surface of the connector, and a sealing cap is mounted on the outer surface of the tamping rod via a sealing bearing. This cell tissue homogenizer, by controlling the rotation of multiple tamping rods, can homogenize cell tissue inside multiple homogenization tubes, resulting in higher homogenization efficiency while preventing splashing of the homogenate and ensuring the accuracy of experimental results.

[0004] The inventors have discovered at least the following problems in the prior art:

[0005] While the existing tissue homogenizers can homogenize cells and tissues inside multiple homogenization tubes with higher homogenization efficiency, each homogenizer needs to be disassembled and rinsed after use before it can be reused, which limits its efficiency.

[0006] Therefore, this solution provides a biological tissue homogenizer to address the aforementioned problems. Utility Model Content

[0007] The purpose of this invention is to provide a biological tissue homogenizer to solve the problem in the prior art that each homogenizer needs to be disassembled and rinsed after completion before it can be reused, which limits efficiency.

[0008] To solve the above-mentioned technical problems, the basic technical solution proposed by this utility model is as follows:

[0009] A biological tissue homogenizer includes a homogenization mechanism, which comprises a base and a support frame. A placement mechanism is slidably connected above the support frame. A hydraulic cylinder is mounted above the support frame, and a transmission box is mounted at the output end of the hydraulic cylinder. A slide rail is fixedly connected below the transmission box. A cleaning mechanism and a wiping mechanism are arranged around the homogenization mechanism, and a water tank and a high-pressure pump are located on one side of the cleaning mechanism. The placement mechanism includes a placement slide plate and a connecting frame one fixedly connected to one side of the placement slide plate. The cleaning mechanism includes a semi-circular frame and spray pipes evenly and vertically arranged inside the semi-circular frame. A connecting frame two is fixedly connected to one side of the semi-circular frame, and a connecting rope is fixedly connected to the outside of the connecting frame two. The other end of the connecting rope is fixedly connected to the connecting frame one. The semi-circular frame is slidably connected below the slide rail. The wiping mechanism includes a water collection tank and a half-frame block fixedly connected to one end of the water collection tank. Two symmetrical wiping components and a squeezing block slidably connected above and below are arranged on the inner side of the half-frame block. The wiping components include a door panel and absorbent cotton adhered to the inner side of the door panel.

[0010] Preferably, a guide wheel is rotatably connected to the top of the base and one side of the support frame, and the connecting rope is wrapped around the periphery of the guide wheel.

[0011] Preferably, the semi-circular frame is fixedly connected to the top of the water collection tank, one end of the semi-circular frame is fixedly connected to one side of the semi-frame block, and a water injection end is provided at the end of the semi-circular frame away from the semi-frame block.

[0012] Preferably, the water injection end is connected to the spray pipe, the inner side of the spray pipe is provided with evenly distributed spray heads, the water injection end is connected to the output end of the high-pressure pump through a hose, and the input end of the high-pressure pump is connected to the water tank.

[0013] Preferably, a drain end is provided below the water collection tank, and the drain end is connected to the waste liquid tank of the water tank through a flexible hose.

[0014] Preferably, a stop rod is fixedly connected to the lower part of the extrusion block, the stop rod passes through the half frame block, a pivot is fixedly connected to the lower part of one side of the door panel, the door panel is rotatably connected to the inner side of the half frame block through the pivot, a torsion spring is connected to the outer periphery of the pivot, and the other end of the torsion spring is connected to the inside of the half frame block.

[0015] Preferably, a drive motor is installed above the transmission box, a rotatably connected homogenizing rod is installed below the transmission box, the slide rail is located on both sides of the homogenizing rod, and a uniformly arranged placement cylinder is fixedly connected above the placement slide plate.

[0016] The beneficial effects of this utility model are:

[0017] I. This utility model, through the coordinated arrangement of the placement mechanism, cleaning mechanism, wiping mechanism, connecting rope and water tank, can achieve automatic cleaning and surface moisture adsorption of the homogenizing rod after homogenization is completed, without the need for manual disassembly and cleaning, which significantly improves the continuous use efficiency of the equipment and solves the technical pain point of traditional homogenizers that need to be disassembled and rinsed one by one.

[0018] II. This utility model, through the coordinated operation of the placement mechanism, cleaning mechanism, wiping mechanism, connecting rope and water tank, allows the placement mechanism and cleaning mechanism to be linked by guide wheels and slide rails. Only a single pull is needed to simultaneously complete the placement and removal of the homogenizing tube, the reset of the cleaning mechanism and the preparation of the tamping rod for cleaning. The operation process is simplified and highly stable, reducing the intensity of manual operation.

[0019] Third, through the coordinated arrangement of the placement mechanism, cleaning mechanism, wiping mechanism, connecting rope and water tank, the wiping components (door panel, absorbent cotton) are automatically reset by the torsion spring, ensuring that the homogenizing rod moves in and out without obstruction. At the same time, the squeezing block can periodically squeeze the absorbent cotton to discharge water, extend the service life of the absorbent cotton and reduce the frequency of replacement. Attached Figure Description

[0020] Figure 1 This is one of the overall perspective views of Embodiment 1 of this utility model;

[0021] Figure 2 This is a second overall perspective view of Embodiment 1 of the present utility model;

[0022] Figure 3 This is an embodiment of the present utility model. Figure 1 A schematic diagram of the middle section;

[0023] Figure 4 This is a schematic diagram showing the disassembled cleaning mechanism and wiping mechanism of Embodiment 1 of this utility model;

[0024] Figure 5 This is a schematic diagram of the wiping mechanism according to Embodiment 1 of this utility model;

[0025] Figure 6 This is a schematic diagram of the wiping assembly according to Embodiment 1 of this utility model.

[0026] Explanation of reference numerals in the attached figures:

[0027] 1. Homogenizing mechanism; 11. Base; 12. Support frame; 13. Hydraulic cylinder; 14. Transmission box; 15. Drive motor; 16. Homogenizing rod; 17. Slide rail; 18. Guide wheel;

[0028] 2. Placement mechanism; 21. Placement slide; 22. Placement tube; 23. Connecting frame one;

[0029] 3. Cleaning mechanism; 31. Semi-circular frame; 32. Water injection end; 33. Spray pipe; 34. Spray head; 35. Connecting frame two;

[0030] 4. Wiping mechanism; 41. Water collection tank; 42. Drainage end; 43. Half frame block; 44. Squeezing block; 45. Support rod;

[0031] 46. ​​Wiping assembly; 461. Door panel; 462. Absorbent cotton; 463. Spindle; 464. Torsion spring;

[0032] 5. Connecting rope; 6. Water tank; 7. High-pressure pump. Detailed Implementation

[0033] Please refer to the following. Figures 1 to 6 As shown, the technical solutions in the embodiments of this utility model are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of this utility model, and not all of them. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of this utility model.

[0034] It should be noted that, in the embodiments of this utility model, the directions shown in the accompanying drawings shall prevail, such as front and back. Figure 1 For the sake of accuracy, the specific details should be as follows: Figure 1 The left side is the front. Figure 1 The right side is the rear; at the same time, as Figure 2 As shown, the horizontal direction is roughly defined as left and right, and the vertical direction is defined as up and down. If a specific orientation changes, the directional indication will also change accordingly.

[0035] This utility model provides a biological tissue homogenizer, including a homogenization mechanism 1. The homogenization mechanism 1 includes a base 11 and a support frame 12. A placement mechanism 2 is slidably connected above the support frame 12. A hydraulic cylinder 13 is installed above the support frame 12. A transmission box 14 is installed at the output end of the hydraulic cylinder 13. A slide rail 17 is fixedly connected below the transmission box 14. A cleaning mechanism 3 and a wiping mechanism 4 are arranged around the homogenization mechanism 1, and a water tank 6 and a high-pressure pump 7 are located on one side of the cleaning mechanism 3.

[0036] The placement mechanism 2 includes a placement slide 21 and a connecting frame 23 fixedly connected to one side of the placement slide 21;

[0037] The cleaning mechanism 3 includes a semi-circular frame 31 and spray pipes 33 that are evenly and vertically arranged inside the semi-circular frame 31. A connecting frame 2 35 is fixedly connected to one side of the semi-circular frame 31. A connecting rope 5 is fixedly connected to the outside of the connecting frame 2 35. The other end of the connecting rope 5 is fixedly connected to the connecting frame 1 23. The semi-circular frame 31 is slidably connected to the bottom of the slide rail 17.

[0038] The wiping mechanism 4 includes a water collection tank 41 and a half-frame block 43 fixedly connected to one end of the water collection tank 41. Two symmetrical wiping components 46 and a squeezing block 44 slidably connected up and down are arranged on the inner side of the half-frame block 43.

[0039] The wiping assembly 46 includes a door panel 461 and an absorbent cotton 462 adhered to the inside of the door panel 461;

[0040] The homogenization mechanism 1 is a biological tissue homogenizer, which has an external controller connected by a circuit to operate the hydraulic cylinder 13, drive motor 15 and high-pressure pump 7. There is a groove above the base 11 for the sliding plate 21 to slide. The output end of the hydraulic cylinder 13 is fixedly connected to one side of the transmission box 14 through a connecting block, and the connecting block is positioned above the connecting rope 5. Therefore, when the transmission box 14 moves down with the cleaning mechanism 3 and the wiping mechanism 4, it will further tighten the placement mechanism 2 through the connecting rope 5. The connecting rope 5 is a tension rope.

[0041] In a further embodiment, a guide wheel 18 is rotatably connected to the top of the base 11 and one side of the support frame 12, and the connecting rope 5 is wrapped around the periphery of the guide wheel 18.

[0042] In this embodiment, the connecting rope 5 rests above the guide wheel 18 of the base 11 and passes under the guide wheel 18 of the support frame 12, and the displacement distance of the placement mechanism 2 is consistent with the displacement distance of the cleaning mechanism 3.

[0043] In a further embodiment, the semi-circular frame 31 is fixedly connected above the water collection tank 41, one end of the semi-circular frame 31 is fixedly connected to one side of the semi-frame block 43, and a water injection end 32 is provided at the end of the semi-circular frame 31 away from the semi-frame block 43.

[0044] In this embodiment, the area enclosed by the semi-circular frame 31, the water collection tank 41, and the semi-circular block 43 is the cleaning area, so that the homogenizing rod 16 can be cleaned by the liquid sprayed from the spray head 34; the semi-circular frame 31 is U-shaped.

[0045] In a further embodiment, the water injection end 32 is connected to the spray pipe 33, and the inner side of the spray pipe 33 is provided with uniformly arranged spray heads 34. The water injection end 32 is connected to the output end of the high-pressure pump 7 through a hose, and the input end of the high-pressure pump 7 is connected to the water tank 6.

[0046] In this embodiment, there are handles on one side of the semi-circular frame 31 and on the side where the slide plate 21 is placed, making it easy to pull; the spray pipe 33 is connected to the water injection end 32; the operation of the high-pressure pump 7 can deliver clean water from the water tank 6 to the spray head 34 and spray it out under pressure.

[0047] In a further embodiment, a drain end 42 is provided below the water collection tank 41, and the drain end 42 is connected to the waste liquid tank of the water tank 6 via a hose.

[0048] In this embodiment, the water tank 6 consists of two water tanks, an upper and a lower one. The upper water tank is a waste liquid tank, which contains a filter assembly for filtering wastewater and then conveying it to the lower water tank. It can also discharge wastewater directly to a larger external wastewater treatment device through a hose.

[0049] In a further embodiment, a stop rod 45 is fixedly connected to the lower part of the pressing block 44, the stop rod 45 passes through the half frame block 43, a rotating shaft 463 is fixedly connected to the lower part of one side of the door panel 461, the door panel 461 is rotatably connected to the inner side of the half frame block 43 through the rotating shaft 463, a torsion spring 464 is connected to the periphery of the rotating shaft 463, and the other end of the torsion spring 464 is connected to the interior of the half frame block 43.

[0050] In this embodiment, the torsion spring 464 ensures that the door panel 461 and the absorbent cotton 462 are always perpendicular to the inner wall of the half-frame block 43, so that there is no obstruction when the homogenizing rod 16 moves in and out, and it will be reset by the torsion spring 464 after moving in and out.

[0051] In a further embodiment, a drive motor 15 is installed above the transmission box 14, a homogenizing rod 16 is rotatably connected below the transmission box 14, a slide rail 17 is located on both sides of the homogenizing rod 16, and a uniformly arranged placement cylinder 22 is fixedly connected above the placement slide plate 21.

[0052] In this embodiment, the transmission box 14 has a gear set inside, which consists of three gears. Each gear has a mounting cylinder below the transmission box 14 via a shaft, so that the homogenizing rod 16 can be mounted below the transmission box 14. The middle gear among the three gears is connected to the output shaft of the drive motor 15. Therefore, after the drive motor 15 operates, it can drive the three homogenizing rods 16 below to rotate. The inside of the placement cylinder 22 is used to insert the homogenizing tube.

[0053] The working principle of this utility model is as follows:

[0054] When biological tissue is placed in homogenization tube and then inserted into placement cylinder 22, the cleaning mechanism 3 can be pulled to move placement mechanism 2 below homogenization rod 16 via connecting rope 5. At this time, hydraulic cylinder 13 and drive motor 15 are activated. The operation of hydraulic cylinder 13 will cause transmission box 14 and drive motor 15 to move down. The operation of drive motor 15 will cause homogenization rod 16 to rotate through gears in transmission box 14, thereby uniformly breaking down biological tissue in homogenization tube.

[0055] After homogenization is complete, the transmission box 14 returns to its initial position, allowing the homogenizing rod 16 to disengage from the homogenizing tube. At this point, the placement mechanism 2 can be pulled to allow the worker to retrieve the homogenizing tube. Simultaneously, the cleaning mechanism 3 and wiping mechanism 4 slide along the guide rail 17 to the bottom of the transmission box 14 via the connecting rope 5. During the sliding process, the homogenizing rod 16 pushes aside the wiping component 46 and then enters the interior of the semi-circular frame 31. The controller then activates the high-pressure pump 7, which sequentially delivers the cleaning solution inside the water tank 6 through the hose water inlet 32 ​​to the spray pipe 33, and finally sprays it out from the spray head 34. This cleans the homogenizing rod 16 after the tissue has been broken up. When the cleaning mechanism 3 is pulled again, the relative displacement of the homogenizing rod 16 will contact the absorbent cotton 462, thereby absorbing the water droplets on the surface of the homogenizing rod 16. Therefore, the homogenizing rod 16 can be automatically cleaned and wiped after tissue breaking up without manual operation, thus improving efficiency.

[0056] When the transmission box 14 moves down, it will take the cleaning mechanism 3 and the wiping mechanism 4 down with it, so that the bottom of the push rod 45 will contact the table first, and the squeezing block 44 will move upward inside the half frame block 43, thereby squeezing the absorbent cotton 462 and squeezing out the absorbed water. This ensures that the absorbent cotton 462 stays dry and reduces the frequency of replacing the absorbent cotton 462.

[0057] Based on the disclosure and teachings of the above specification, those skilled in the art can make changes and modifications to the above embodiments. Therefore, this utility model is not limited to the specific embodiments disclosed and described above, and some modifications and changes to this utility model should also fall within the protection scope of the claims of this utility model. Furthermore, although some specific terms are used in this specification, these terms are only for convenience of explanation and do not constitute any limitation on this utility model.

Claims

1. A biological tissue homogenizer, comprising a homogenizing mechanism (1), characterized in that, The homogenizing mechanism (1) includes a base (11) and a support frame (12). A placement mechanism (2) is slidably connected above the support frame (12). A hydraulic cylinder (13) is installed above the support frame (12). A transmission box (14) is installed at the output end of the hydraulic cylinder (13). A slide rail (17) is fixedly connected below the transmission box (14). A cleaning mechanism (3) and a wiping mechanism (4) are connected vertically around the homogenizing mechanism (1). A water tank (6) and a high-pressure pump (7) are located on one side of the cleaning mechanism (3). The placement mechanism (2) includes a placement slide (21) and a connecting frame (23) fixedly connected to one side of the placement slide (21); The cleaning mechanism (3) includes a semi-circular frame (31) and spray pipes (33) arranged vertically and evenly inside the semi-circular frame (31). A connecting frame two (35) is fixedly connected to one side of the semi-circular frame (31), and a connecting rope (5) is fixedly connected to the outside of the connecting frame two (35). The other end of the connecting rope (5) is fixedly connected to the connecting frame one (23). The semi-circular frame (31) is slidably connected to the bottom of the slide rail (17). The wiping mechanism (4) includes a water collection tank (41) and a half-frame block (43) fixedly connected to one end of the water collection tank (41). The inner side of the half-frame block (43) is provided with two symmetrical wiping components (46) and a squeezing block (44) that slides vertically. The wiping assembly (46) includes a door panel (461) and absorbent cotton (462) adhered to the inside of the door panel (461).

2. The biological tissue homogenizer according to claim 1, characterized in that: A guide wheel (18) is rotatably connected to the top of the base (11) and one side of the support frame (12), and the connecting rope (5) is wrapped around the periphery of the guide wheel (18).

3. The biological tissue homogenizer according to claim 1, characterized in that: The semi-circular frame (31) is fixedly connected above the water collection tank (41), one end of the semi-circular frame (31) is fixedly connected to one side of the semi-frame block (43), and a water injection end (32) is provided at the end of the semi-circular frame (31) away from the semi-frame block (43).

4. A biological tissue homogenizer according to claim 3, characterized in that: The water injection end (32) is connected to the spray pipe (33), and the inner side of the spray pipe (33) is provided with spray heads (34) evenly distributed. The water injection end (32) is connected to the output end of the high pressure pump (7) through a hose, and the input end of the high pressure pump (7) is connected to the water tank (6).

5. A biological tissue homogenizer according to claim 1, characterized in that: A drain end (42) is provided below the water collection tank (41), and the drain end (42) is connected to the waste liquid tank of the water tank (6) through a hose.

6. A biological tissue homogenizer according to claim 1, characterized in that: A stop rod (45) is fixedly connected to the lower part of the extrusion block (44), and the stop rod (45) passes through the half frame block (43). A pivot (463) is fixedly connected to the lower part of one side of the door panel (461). The door panel (461) is rotatably connected to the inner side of the half frame block (43) through the pivot (463). A torsion spring (464) is connected to the outer periphery of the pivot (463), and the other end of the torsion spring (464) is connected to the interior of the half frame block (43).

7. A biological tissue homogenizer according to claim 1, characterized in that: A drive motor (15) is installed above the transmission box (14), and a rotatably connected homogenizing rod (16) is installed below the transmission box (14). The slide rail (17) is located on both sides of the homogenizing rod (16), and a uniformly arranged placement cylinder (22) is fixedly connected above the placement slide plate (21).

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