Full-automatic blood sample pretreatment experimental device

Abstract

The utility model relates to a full-automatic blood sample pretreatment experiment device, and relates to the technical field of pretreatment experiment devices, and the full-automatic blood sample pretreatment experiment device comprises a tube rack module which comprises a blood collection tube rack, a centrifugal tube rack, a suction head plate and a reagent bottle rack; the mechanical arm module comprises a carrying mechanical arm and a pipetting mechanical arm which can move in the X, Y and Z directions; the reverse cover pulling module comprises a reverse assembly and a cover pulling assembly; the reversing assembly is used for driving the blood collection tube to rotate in the vertical direction; the cover pulling assembly is used for clamping a blood collection tube; the cap screwing module comprises a cap screwing air bag and a driving assembly, the cap screwing air bag is used for clamping the centrifugal tube, and the driving assembly is used for driving the cap screwing air bag to rotate in the horizontal direction; the vortex module is used for carrying out vortex uniform mixing operation; the centrifugal module is used for conducting centrifugal operation. By arranging the experimental device capable of automatically pretreating the blood sample, the problem that errors are easy to introduce in the prior art is effectively solved, the treatment efficiency is improved, and the experimental requirements of a large number of samples are met.

Description

Technical Field

[0001] This application relates to the field of pretreatment experimental apparatus, and in particular to a fully automated blood sample pretreatment experimental apparatus. Background Technology

[0002] Blood samples, as the core carrier of medical testing, have become the most commonly used test samples in clinical diagnosis due to their easy availability and high efficiency in monitoring physiological states. With the development of immunoassay technology, fully automated chemiluminescence immunoassay analyzers, with their advantages of high sensitivity and high specificity, are widely used in the detection of key items such as tumor markers, hormones, and infectious disease markers.

[0003] However, existing technologies still face significant bottlenecks: First, the reliance on and limitations of sample pretreatment; while current chemiluminescence immunoassay analyzers have automated detection, blood samples still require manual pretreatment steps such as centrifugation, aliquoting, and dilution before being processed. Manual operation easily introduces errors, directly affecting detection accuracy, leading to false results or duplicate testing, and increasing medical costs. Second, the lack of automation; although modern fully automated analyzers (such as chemiluminescence and biochemical analyzers) are designed based on blood testing, the pretreatment step has not yet been integrated into the automated process. Manually transferring samples to micro-volume testing cups is not only inefficient (especially in high-volume testing scenarios), but can also cause equipment malfunctions due to the sample tube separating gel clogging the instrument's sampling needle. Finally, there are challenges in quality control; current technologies lack standardized control over the pretreatment process. For example, patient serum from patients using isomeric drugs may interfere with antigen-antibody reactions; such problems must be identified through retrospective analysis of abnormal results and cannot be detected during the pretreatment stage. Furthermore, clinical laboratories face pressure from surging sample volumes, making manual pretreatment a bottleneck to testing efficiency. Utility Model Content

[0004] In view of the above problems, this application is made in order to provide a fully automated blood sample pretreatment experimental apparatus that overcomes or at least partially solves the above problems.

[0005] The fully automated blood sample pretreatment experimental device provided in this application adopts the following technical solution:

[0006] A fully automated blood sample pretreatment experimental device includes a workbench and a tube rack module, a robotic arm module, an inverting cap removal module, a cap screwing module, a vortex module, and a centrifugation module disposed on the workbench.

[0007] The tube rack module includes at least one blood collection tube rack for storing blood collection tubes, at least one centrifuge tube rack for storing centrifuge tubes, at least one pipette tip plate for storing pipette tips, and at least one reagent bottle rack for placing reagent bottles.

[0008] The robotic arm module includes a transport robotic arm and a pipetting robotic arm that can move along the X, Y, and Z directions; the transport robotic arm is used to transport tubes from one module to another; the pipetting robotic arm is used to transfer sample liquid or reagents from one tube to another.

[0009] The inverting and cap-removing module includes an inverting component and a cap-removing component; the inverting component is used to drive the blood collection tube to rotate in the vertical direction to perform a mixing operation; the cap-removing component is used to clamp the blood collection tube and cooperate with the transport robotic arm to complete the cap-removing operation.

[0010] The capping module includes a capping airbag that can be inflated and deflated, and a drive assembly. The capping airbag is used to clamp the centrifuge tube, and the drive assembly is used to drive the capping airbag to rotate in the horizontal direction.

[0011] The vortex module is used to perform vortex mixing operation, and includes a support plate for supporting the tube body and an eccentric component for driving the support plate to rotate eccentrically.

[0012] The centrifugation module is used to perform centrifugation operations.

[0013] Optionally, the handling robotic arm includes a support frame, a swing motor, and handling grippers;

[0014] The swing motor is mounted on the support frame and is used to drive the transport gripper to deflect at a certain angle in the vertical direction. The transport gripper is equipped with a retractable gripper.

[0015] The pipetting robotic arm includes at least one pipetting needle and at least one pipetting pump, the pipetting pump being connected to the pipetting needle.

[0016] Optionally, the transport robotic arm and the pipetting robotic arm share an X-direction movement component.

[0017] Optionally, the inverting assembly includes a rotary table that can move in both horizontal and vertical directions and a cap-removing gripper disposed on the rotary table, wherein the rotary table is used to drive the cap-removing gripper to rotate in the vertical direction.

[0018] The cap removal assembly includes an inflatable and deflated cap removal airbag, which is used to clamp the tube body.

[0019] Optionally, the workbench is provided with a number of blood collection tube bases corresponding to the blood collection tube frame, and the blood collection tube frame and the blood collection tube bases are movably connected.

[0020] Optionally, the blood collection tube rack is provided with a clamping position for use in conjunction with the transport robotic arm.

[0021] Optionally, a barcode scanner is also provided on the workbench, and the barcode scanner is positioned relative to the blood collection tube rack;

[0022] The blood collection tube holder is provided with scanning holes that are connected to the blood collection tube openings, and the blood collection tube openings are also provided with spring clips for contacting the blood collection tubes.

[0023] Optionally, the centrifuge tube rack includes a centrifuge base, a first support platform, and a plurality of second support platforms for placing centrifuge tubes, arranged sequentially from bottom to top;

[0024] The first support platform and the centrifuge base are movably connected, and a plurality of second support platforms are arranged side by side on the first support platform, and all of them are movably connected to the first support platform.

[0025] Optionally, the fully automated blood sample pretreatment experimental device further includes a pipette tip recovery chamber and at least one pipette tip removal slot, the pipette tip removal slot being disposed above the pipette tip recovery chamber.

[0026] Optionally, it also includes an auxiliary base disposed on one side of the cap removal assembly, the auxiliary base being used for movable connection of the blood collection tube frame;

[0027] Furthermore, the transport robotic arm (21) can transport the blood collection tube frame (11) between the blood collection tube base (7) and the auxiliary base (9).

[0028] In summary, this application has the following beneficial technical effects: by setting up an experimental device that can automatically perform blood sample pretreatment, this application effectively solves the problem of easy introduction of errors in the prior art, improves processing efficiency, and adapts to the experimental needs of a large number of samples. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application.

[0030] Figure 2 This is a schematic diagram of the centrifuge tube rack in an embodiment of this application.

[0031] Figure 3 This is a schematic diagram of the inverted cap removal module in an embodiment of this application.

[0032] Explanation of reference numerals in the attached diagram: 1. Tube rack module; 11. Blood collection tube rack; 111. Clamping position; 112. Scanning hole; 113. Spring; 12. Centrifuge tube rack; 121. Centrifuge base; 122. First support platform; 123. Second support platform; 13. Pipe tip plate; 14. Reagent bottle rack; 2. Robotic arm module; 21. Handling robotic arm; 211. Support frame; 212. Handling gripper; 213. Swing motor; 22. Pipetting robotic arm; 3. Inverting and capping module; 31. Inverting component; 311. Rotary stage; 312. Capping gripper; 32. Capping component; 321. Capping airbag; 4. Capping module; 41. Capping airbag; 42. Drive component; 5. Vortex module; 51. Support plate; 6. Centrifuge module; 7. Blood collection tube base; 8. Pipe tip recovery compartment; 81. Pipe tip disassembly slot; 9. Auxiliary base; 10. Barcode scanner. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of this invention. Obviously, the described embodiments are one embodiment of this invention, and not all embodiments. Based on the described embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0034] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.

[0035] This embodiment provides a fully automated experimental device for blood sample pretreatment.

[0036] Reference Figure 1 , Figure 2 A fully automated blood sample pretreatment experimental device includes a workbench and a tube rack module 1, a robotic arm module 2, an inverting cap removal module 3, a cap screwing module 4, a vortex module 5, and a centrifugation module 6, all located at corresponding workstations on the workbench.

[0037] The tube rack module 1 includes at least one blood collection tube rack 11 for storing blood collection tubes, at least one centrifuge tube rack 12 for storing centrifuge tubes, at least one pipette tip plate 13 for storing pipette tips, and at least one reagent bottle rack 14 for placing reagent bottles.

[0038] To facilitate the placement and removal of blood collection tube racks 11 by experimental personnel, the workbench is equipped with the same number of blood collection tube bases 7 as the blood collection tube racks 11, with each blood collection tube base 7 being movably connected to a corresponding blood collection tube rack 11. Each blood collection tube base 7 is equipped with a detection sensor to identify whether a sampling tube rack is present at that workstation.

[0039] The centrifuge tube rack 12 includes a centrifuge base 121, a first support platform 122, and a plurality of second support platforms 123 for placing centrifuge tubes, arranged sequentially from bottom to top. The first support platform 122 is movably connected to the centrifuge base 121, and the plurality of second support platforms 123 are arranged side by side on the first support platform 122 and are all movably connected to the first support platform 122 to facilitate partial or complete removal and placement of centrifuge tubes.

[0040] In the specific implementation process, the movable connection between the blood collection tube base 7 and the blood collection tube frame 11, the centrifuge base 121 and the first support platform 122, and the first support platform 122 and the second support platform 123 can all be achieved by means of card strip and card slot connection, magnetic adsorption, etc.

[0041] The reagent bottle rack 14 is equipped with a cap for opening and closing the mouth of the reagent bottle. The opening and closing of the cap can be achieved by a control mechanism such as a cylinder or push rod.

[0042] Reference Figure 1 The robotic arm module 2 includes a handling robotic arm 21 and a liquid pipetting robotic arm 22.

[0043] The handling robotic arm 21 is used to transport the corresponding tube from one module to another so that the corresponding module can perform corresponding processing operations. It includes a carrier frame 211 that can move along the X, Y, and Z directions and a handling gripper 212 set on the carrier frame 211. The handling gripper 212 is equipped with a retractable gripper for holding the tube (that is, the gripper can retract or expand in the horizontal direction to realize the operation of holding the tube).

[0044] The pipetting robotic arm 22 is used to transfer sample liquid or reagent from one tube to another, and includes at least one pipetting needle movable in the X, Y, Z directions and at least one pipetting pump;

[0045] The pipette can be detachably connected to the pipette tip stored on the tip plate 13. The pipette is connected to the pipetting pump to achieve pipetting operations while preventing cross-contamination.

[0046] In practice, it is preferable to have two pipettes: one for transferring reagents and one for transferring blood samples, to further avoid cross-contamination.

[0047] To facilitate the disassembly and collection of used suction heads, the workbench is also equipped with a suction head recycling bin 8 and at least one suction head disassembly slot 81. The suction head disassembly slot 81 is located above the suction head recycling bin 8 and is tapered in shape. It is used to engage the top edge of the suction head to cooperate with the Z-axis motion component to disassemble the suction head.

[0048] In practice, to save space and cost, the handling robotic arm 21 and the pipetting robotic arm 22 can share the same X-direction movement component.

[0049] Reference Figure 1 , Figure 3 The inverting and cap-removing module 3 includes an inverting component 31 and a cap-removing component 32.

[0050] The inversion component 31 is used to drive the blood collection tube to rotate in the vertical direction to achieve the inversion and mixing operation of the sampled blood. The inversion component 31 includes a rotating platform 311 and a cap removal gripper 312. The rotating platform 311 can move in both horizontal and vertical directions, and the rotating platform 311 itself can rotate in the vertical direction. The cap removal gripper 312 is set on the rotating platform 311 and rotates together with the rotating platform 311 to hold the blood collection tube to rotate in the vertical direction, thereby achieving the inversion and mixing operation.

[0051] The cap removal assembly 32 is located at the next station after the inverting assembly 31 and is used to cooperate with the handling robotic arm 21 to perform cap removal or cap closing operations on the blood collection tube, so as to realize the opening and closing control of the blood collection tube.

[0052] The cap removal assembly 32 includes a cap removal airbag 321 that can be inflated and deflated. The cap removal airbag 321 is used to hold the tube body so that after the blood collection tube has been inverted and mixed, it is placed in the cap removal airbag 321 and cooperates with the cap removal claw 312 to open the blood collection tube.

[0053] To improve the efficiency of inverting and removing the cap, the workbench is also equipped with an auxiliary base 9 located on one side of the cap removal assembly 32. The auxiliary base 9 is used to place the blood collection tube frame 11 and is movably connected to the blood collection tube frame 11. At the same time, the blood collection tube frame 11 is also equipped with a clamping position 111 that is adapted to the gripper of the transport robotic arm 21, so that the transport robotic arm 21 can transport the blood collection tube frame 11 between the blood collection tube base 7 and the auxiliary base 9.

[0054] Reference Figure 1 The capping module 4 is used to cap the centrifuge tubes transported by the robotic arm 21, thereby controlling the opening and closing of the centrifuge tube caps.

[0055] The capping module 4 includes a capping airbag 41 and a drive assembly 42. The capping airbag 41 can be inflated and deflated and is used to clamp the centrifuge tubes transported by the handling robot arm 21. The drive assembly 42 is used to drive the capping airbag 41 to rotate in the horizontal direction.

[0056] When performing the opening or closing operation of centrifuge tubes, the handling robot arm 21 inserts the centrifuge tube into the capping airbag 41. The capping airbag 41 is inflated and clamps the centrifuge tube. Then, the drive component 42 controls the capping airbag 41 to rotate in the corresponding direction. At this time, the handling robot arm 21 is in a clamping state on the centrifuge tube cap. Therefore, the opening and closing operation of the centrifuge tube can be realized during the rotation of the capping airbag 41.

[0057] Reference Figure 1The vortex module is located at the next station after the capping module 4 and is used to perform vortex mixing operation. It includes a support plate 51 for carrying centrifuge tubes and an eccentric component for driving the support plate 51 to rotate (the eccentric component includes a motor and an eccentric rotor mounted on the motor, which is a mature existing technology structure and will not be described in detail in this application).

[0058] When performing vortex mixing, the transport robot arm 21 transports the centrifuge tube to the carrier tray and makes the bottom of the centrifuge tube abut against the carrier tray 51. Then the eccentric component is activated, and at the same time the grippers of the transport robot arm 21 extend outward a certain distance, leaving a certain movement gap at the top of the centrifuge tube, so that the vortex mixing operation can be performed.

[0059] Reference Figure 1 Centrifuge module 6 is located at the next station after vortex module 5 and is used for centrifugation operations.

[0060] Centrifugation module 6 includes a centrifuge.

[0061] Since the holes for placing centrifuge tubes in the centrifuge module 6 are inclined, in order to facilitate the insertion of centrifuge tubes into the holes, the handling robot arm 21 also includes a swing motor 213 disposed between the support frame 211 and the handling gripper 212. The swing motor 213 is used to drive the handling gripper 212 to deflect at a certain angle in the vertical direction.

[0062] In practice, the centrifuge is also equipped with a protective cover, which is opened and closed by a control mechanism such as a cylinder and a push rod.

[0063] Reference Figure 1 , Figure 3 The workbench is also equipped with a barcode scanner 10, which is positioned opposite the blood collection tube rack 11 and is used to scan the barcode information on the blood collection tubes.

[0064] To facilitate accurate scanning of the sampling blood vessel labels by the barcode scanner 10, the blood collection tube holder 11 is provided with scanning holes 112 that correspond to and communicate with the blood collection tube openings. At the same time, a spring clip 113 is also provided in the blood collection tube opening to abut against the blood collection tube, so as to prevent the blood collection tube placed in the opening from rotating and affecting the alignment of the labeling area with the barcode scanner 10, thereby further ensuring the accuracy of the barcode scanner 10 in scanning the labeling information of the sampling blood vessels.

[0065] The workflow of a fully automated blood sample pretreatment experimental device according to an embodiment of this application is as follows:

[0066] Step 1: Install the blood collection tube frame 11 sequentially on the blood collection tube base 7, and install them sequentially from the direction away from the barcode scanner 10 to the direction closer to the barcode scanner 10, to ensure that the barcode scanner 10 accurately scans the barcode information on the blood collection tube.

[0067] Step 2: The robotic arm 21 transports the blood collection tube holder 11 and installs it on the auxiliary base 9;

[0068] Step 3: The cap-removing gripper 312 grabs the blood collection tube and removes it from the blood collection tube. Then, the rotating table 311 drives the blood collection tube to rotate vertically to complete the inverting and mixing operation.

[0069] Step 4: The cap-removing jaws 312 place the inverted and mixed blood collection tube into the cap-removing airbag 321. The cap-removing airbag 321 inflates and clamps the blood collection tube. The cap-removing jaws 312 move upward to remove the cap.

[0070] Step 5: Use two pipettes to pick up the pipette tips, then use one pipette to draw a certain amount of reagent into the reagent bottle and the other pipette to draw a certain amount of sample into the blood collection tube;

[0071] Step 6: The robotic arm 21 moves the centrifuge tube to the capping module 4 to open the cap, and the pipette adds reagents and samples into the centrifuge tube;

[0072] Step 7: Close the cap on the centrifuge tube and transport the centrifuge tube to the vortex module 5 for vortex mixing.

[0073] Step 8: The robotic arm 21 moves the centrifuge tubes that have been vortex-mixed into the centrifuge. The centrifuge closes its protective cover to complete the centrifugation operation.

[0074] Step 9: The robotic arm 21 moves the centrifuge tubes back to the centrifuge tube rack 12, completing the pretreatment process.

[0075] The movement of the relevant structures or components in this application along the horizontal and vertical (or X, Y, Z) directions can be achieved by common structures such as ball screws / trapezoidal screws, synchronous belts / toothed belts, gear racks, hydraulic cylinders, and pneumatic cylinders; rotational movement can be achieved by common structures such as gears, pulleys, and motors. The appropriate structure can be selected according to the specific scenario.

[0076] The above are all preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A fully automated blood sample pre-treatment laboratory device, characterized by: It includes a workbench and a pipe rack module (1), a robotic arm module (2), an inverted cap removal module (3), a cap screwing module (4), a vortex module (5), and a centrifuge module (6) set on the workbench; The tube rack module (1) includes at least one blood collection tube rack (11) for storing blood collection tubes, at least one centrifuge tube rack (12) for storing centrifuge tubes, at least one pipette tip plate (13) for storing pipette tips, and at least one reagent bottle rack (14) for placing reagent bottles. The robotic arm module (2) includes a transport robotic arm (21) and a pipetting robotic arm (22) that can move along the X, Y, and Z directions; the transport robotic arm (21) is used to transport tubes from one module to another; the pipetting robotic arm (22) is used to transfer sample liquid or reagents from one tube to another. The inverting and cap-removing module (3) includes an inverting component (31) and a cap-removing component (32); the inverting component (31) is used to drive the blood collection tube to rotate in the vertical direction to perform a mixing operation; the cap-removing component (32) is used to clamp the blood collection tube and cooperate with the transport robotic arm (21) to complete the cap-removing operation. The capping module (4) includes a capping airbag (41) that can be inflated and deflated and a drive assembly (42). The capping airbag (41) is used to clamp the centrifuge tube, and the drive assembly (42) is used to drive the capping airbag (41) to rotate in the horizontal direction. The vortex module (5) is used to perform vortex mixing operation, and includes a support plate (51) for supporting the tube body and an eccentric component for driving the support plate (51) to rotate eccentrically. The centrifugation module (6) is used to perform centrifugation operations.

2. The fully automated blood sample pre-treatment laboratory device according to claim 1, characterized in that The handling robotic arm (21) includes a support frame (211), a swing motor (213), and a handling gripper (212); The swing motor (213) is mounted on the support frame (211) and is used to drive the transport gripper (212) to deflect at a certain angle in the vertical direction. The transport gripper (212) is equipped with a retractable gripper. The pipetting robot arm (22) includes at least one pipetting needle and at least one pipetting pump, the pipetting pump being connected to the pipetting needle.

3. The fully automated blood sample pretreatment experimental apparatus according to claim 1 or 2, characterized in that: The transport robotic arm (21) and the pipetting robotic arm (22) share an X-direction movement component.

4. The fully automated blood sample pretreatment experimental device according to claim 1, characterized in that: The inverting assembly (31) includes a rotating platform (311) that can move in both horizontal and vertical directions, and a cap-removing gripper (312) disposed on the rotating platform (311), wherein the rotating platform (311) is used to drive the cap-removing gripper (312) to rotate in the vertical direction. The cap removal assembly (32) includes an inflatable and deflated cap removal airbag (321) for holding the tube body.

5. The fully automated blood sample pretreatment experimental device according to claim 1, characterized in that: The workbench is provided with a number of blood collection tube bases (7) corresponding to the blood collection tube frame (11), and the blood collection tube frame (11) and the blood collection tube bases (7) are movably connected.

6. The fully automated blood sample pretreatment experimental device according to claim 5, characterized in that: The blood collection tube rack (11) is provided with a clamping position (111) for use in conjunction with the transport robotic arm (21).

7. The fully automated blood sample pretreatment experimental device according to claim 1, characterized in that: The workbench is also equipped with a barcode scanner (10), which is positioned relative to the blood collection tube frame (11); The blood collection tube holder (11) is provided with a scanning hole (112) that is connected to the blood collection tube hole, and a spring piece (113) for contacting the blood collection tube is also provided in the blood collection tube hole.

8. The fully automated blood sample pretreatment experimental device according to claim 1, characterized in that: The centrifuge tube rack (12) includes a centrifuge base (121), a first support platform (122), and a plurality of second support platforms (123) for placing centrifuge tubes arranged sequentially from bottom to top; The first support platform (122) and the centrifugal base (121) are movably connected, and a plurality of second support platforms (123) are arranged side by side on the first support platform (122), and all of them are movably connected to the first support platform (122).

9. The fully automated blood sample pretreatment experimental device according to claim 1, characterized in that: The fully automated blood sample pretreatment experimental device also includes a pipette tip recovery chamber (8) and at least one pipette tip removal slot (81), the pipette tip removal slot (81) being disposed above the pipette tip recovery chamber (8).

10. The fully automated blood sample pretreatment experimental device according to claim 5, characterized in that: It also includes an auxiliary base (9) disposed on one side of the cap removal assembly (32), the auxiliary base (9) being used for the movable connection of the blood collection tube frame (11); Furthermore, the transport robotic arm (21) can transport the blood collection tube frame (11) between the blood collection tube base (7) and the auxiliary base (9).

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