A purification sample injection bottle with sample solution filtering function

Abstract

The utility model discloses a kind of purification sample introduction bottles with sample solution filtering function, it is related to liquid chromatography, mass spectrum analysis field. Including bottle body and bottle cap, the filter core that can slide up and down along bottle body inner wall is equipped in the bottle body, the filter core includes inside through bushing, the sleeve bottom outside is fixed with the sealing ring that is closely combined with bottle body inner wall, purification filler and filter membrane are sequentially equipped from below to above in bushing bottom opening, the bushing upper portion is equipped with exhaust hole, the bottle cap bottom is equipped with jack, the bushing upper portion is inserted in insertion slot, the bottle cap bottom is sealedly connected with bottle body upper portion opening. The utility model is internally provided with the filter core that can slide up and down in bottle body, when using, by pressing filter core downwards, the impurity of sample solution in bottle body can be filtered, and filtered sample solution is extracted to filter core inside, to realize the filtering function of sample solution, whole process is simple and convenient to operate, and greatly reduce the processing cost of sample solution.

Description

Technical Field

[0001] This utility model relates to the fields of liquid chromatography and mass spectrometry analysis, and more specifically, to a purified sample injection bottle with built-in sample solution filtration function. Background Technology

[0002] Sample vials are commonly used containers in the chemical and medical fields to hold analytes. They have wide applications in chemical analysis and testing, such as in liquid chromatography, liquid chromatography-mass spectrometry, gas chromatography, and gas chromatography-mass spectrometry. A typical liquid chromatography vial consists of a glass body, a plastic cap, and a sealing gasket, and is used in the autosampler of a liquid chromatograph.

[0003] Filtration of the sample is a crucial step before performing liquid chromatography analysis. The presence of impurities in the sample can significantly impact the liquid chromatograph, potentially clogging the flow channels and damaging the instrument, resulting in substantial losses. Ordinary glass vials lack filtration capabilities and cannot process sample solutions independently. Typically, a disposable syringe is used to draw the sample solution, which is then fitted with a filter head and injected into the vial. This process is cumbersome, time-consuming, and labor-intensive. The use of disposable syringes and filter heads also increases the cost of sample solution processing. Utility Model Content

[0004] To address the shortcomings of existing technologies, the purpose of this invention is to provide a purified sample inlet bottle that integrates sample solution filtration, is simple and convenient to operate, and has low operating costs.

[0005] This utility model is achieved using the following technical solution:

[0006] A purified sample inlet bottle with built-in sample solution filtration function includes a bottle body and a bottle cap. The bottle body is provided with a filter element that can slide up and down along the inner wall of the bottle. The filter element includes an internally penetrating sleeve. A sealing ring that fits tightly against the inner wall of the bottle is fixed on the outer side of the bottom of the sleeve. Purification packing material and a filter membrane are arranged sequentially from bottom to top in the bottom opening of the sleeve. The upper part of the sleeve is provided with an exhaust hole. The bottom of the bottle cap is provided with an insertion hole. The upper part of the sleeve is inserted into the slot. The bottom of the bottle cap is sealed to the upper opening of the bottle body.

[0007] Furthermore, the bottom of the bottle cap is provided with a sealing plug, which can be sealed to the opening at the top of the bottle.

[0008] Furthermore, the top of the bottle cap is provided with a cross-shaped pre-cut.

[0009] Furthermore, a retaining ring is fixedly provided on the outer side of the sleeve at a position upward away from the sealing ring.

[0010] Furthermore, the purification packing includes one or more of magnesium sulfate packing, GCB packing, PSA packing, and C18 packing.

[0011] Furthermore, the outer and inner diameters of the upper opening of the sleeve gradually decrease from top to bottom.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] (1) This utility model has a filter element that can move up and down inside the sample bottle. When in use, the impurities of the sample solution in the bottle can be filtered by pressing down the filter element, and the filtered sample solution can be extracted into the filter element, thereby realizing the filtration function of the sample solution. The whole process is simple and convenient to operate and greatly reduces the processing cost of the sample solution.

[0014] (2) The filter element of this utility model is provided with a sleeve, and the bottom of the sleeve is provided with a purification packing and a filter membrane from bottom to top. During filtration, the sample is first dried and impurities are adsorbed by the purification packing, and then the impurities are further filtered by the filter membrane. It has the advantages of clean impurity treatment and good purification effect.

[0015] (3) The outer diameter and inner diameter of the upper opening of the sleeve in this utility model gradually decrease from top to bottom, and the opening is generally funnel-shaped. This structure can effectively prevent the automatic sampling needle of the liquid chromatograph from being inserted into the edge of the sleeve when taking samples. In addition, the inclined inner wall can also guide the sampling needle, so that the sampling needle can accurately enter the inside of the sleeve for sampling. Attached Figure Description

[0016] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0017] Figure 2 This is an exploded view of the present invention.

[0018] Figure 3 This is a cross-sectional view of the present invention.

[0019] In the diagram: 1. Bottle body; 2. Bottle cap; 21. Slot; 22. Cross pre-cut; 23. Sealing plug; 3. Filter element; 31. Sleeve; 32. Retaining ring; 33. Sealing ring; 34. Purification packing; 35. Filter membrane; 36. Vent. Detailed Implementation

[0020] The present invention will be further described below with reference to the accompanying drawings.

[0021] like Figure 1-3As shown, the present invention discloses a purified sample inlet bottle with built-in sample solution filtration function, comprising a bottle body 1 and a bottle cap 2. The bottle body 1 is provided with a filter element 3 that can slide up and down along the inner wall of the bottle body 1. The filter element 3 includes an internally penetrating sleeve 31. A sealing ring 33 that fits tightly against the inner wall of the bottle body 1 is fixed on the outer side of the bottom of the sleeve 31. A purification packing 34 and a filter membrane 35 are arranged sequentially from bottom to top in the bottom opening of the sleeve 31. An exhaust hole 36 is provided at the upper part of the sleeve 31. A slot 21 is provided at the bottom of the bottle cap 2. The upper opening of the sleeve 31 is inserted into the slot 21. The bottom of the bottle cap 2 is sealed to the upper opening of the bottle body 1.

[0022] Furthermore, the bottom of the bottle cap 2 is provided with a sealing plug 23, which can be sealed to the opening at the top of the bottle body 1.

[0023] Furthermore, the top of the bottle cap 2 is provided with a cross-shaped pre-cut 22. The depth of the cross-shaped pre-cut 22 does not penetrate the bottle cap 2 to maintain its sealing. The cross-shaped pre-cut 22 is used to facilitate the automatic sampling needle of the liquid chromatograph to penetrate the bottle cap 2 and insert into the sleeve 31 for sampling.

[0024] Furthermore, a retaining ring 32 is fixedly provided on the outer side of the sleeve 31 at a position away from the sealing ring 33. The retaining ring 32 serves to support the sleeve 31 and prevent the filter element 3 from swaying left and right during the up and down movement.

[0025] Furthermore, the purification packing material 34 includes one or more of magnesium sulfate packing material, GCB packing material, PSA packing material, and C18 packing material. Magnesium sulfate packing material can be used as an adsorbent to remove metal ions from the sample solution. GCB packing material undergoes special surface treatment and has extremely strong adsorption capacity, making it particularly suitable for adsorbing planar molecules such as pigments, phenols, chloroaniline, organochlorine pesticides, and carbamates. PSA packing material is mainly used to remove impurities such as sugars, fatty acids, organic acids, lipids, and some pigments from the sample. C18 packing material is a chromatographic packing material made of silica gel or other porous materials with carbon chain surface modification. First, C18 packing material exhibits weak polarity, thus it can better separate compounds with similar chemical properties. Second, C18 packing material has a large surface area and high adsorption capacity, which can effectively capture and separate target molecules.

[0026] Furthermore, the outer and inner diameters of the upper opening of the sleeve 31 gradually decrease from top to bottom, and the opening is generally funnel-shaped. This structure can effectively prevent the automatic sampling needle of the liquid chromatograph from inserting into the edge of the sleeve 31 when sampling, and the inclined inner wall can also guide the sampling needle, so that the sampling needle can accurately enter the inside of the sleeve 31 for sampling.

[0027] How to use this utility model:

[0028] First, the top opening of the filter element 3 is sealed to the slot 21 of the bottle cap 2. Then, a certain amount of sample solution to be filtered is injected into the bottle body 1. Next, the bottom of the filter element 3 is inserted into the bottle body 1. The sealing ring 33 at the bottom of the filter element 3 fits tightly against the inner wall of the bottle body 1 to achieve a seal. The retaining ring 32 also fits tightly against the inner wall of the bottle body 1, thereby maintaining the stability of the filter element 3 during its up-and-down movement. Then, the filter element 3 is pressed to insert it to the bottom of the bottle body 1. The sample solution to be filtered in the bottle body 1 passes through the purification packing 34 and the filter membrane 35 in sequence under pressure and enters the sleeve 31 of the filter element 3. The air in the sleeve 31 is discharged through the exhaust hole 36, allowing the filtered sample solution to smoothly enter the sleeve 31. When the bottom of the filter element 3 contacts the bottom of the bottle body 1, the sealing plug 23 at the bottom of the bottle cap 2 fits tightly against the opening of the bottle body 1, thereby sealing the opening of the bottle body 1.

[0029] After the filter element 3 is inserted into the bottom of the bottle body 1, the overall dimensions of the vial are consistent with those of a regular glass vial. Therefore, this disposable vial that has completed filtration can be directly loaded onto the autosampler tray of the liquid chromatograph. The autosampler needle of the liquid chromatograph passes through the cross pre-cut 22 of the cap 2 and is inserted into the inside of the sleeve 31 through the trumpet-shaped sampling port at the top of the sleeve 31.

Claims

1. A purified sample inlet bottle with built-in sample solution filtration function, comprising a bottle body (1) and a bottle cap (2), characterized in that: The bottle body (1) is provided with a filter element (3) that can slide up and down along the inner wall of the bottle body (1). The filter element (3) includes an internal through sleeve (31). A sealing ring (33) that fits tightly against the inner wall of the bottle body (1) is fixed on the outer side of the bottom of the sleeve (31). A purification packing (34) and a filter membrane (35) are arranged sequentially from bottom to top in the bottom opening of the sleeve (31). An exhaust hole (36) is provided at the top of the sleeve (31). A slot (21) is provided at the bottom of the bottle cap (2). The upper part of the sleeve (31) is inserted into the slot (21). The bottom of the bottle cap (2) is sealed to the upper opening of the bottle body (1).

2. The purified sample inlet vial according to claim 1, characterized in that: The bottle cap (2) has a sealing plug (23) at the bottom, which can be sealed to the upper opening of the bottle body (1).

3. The purified sample inlet vial according to claim 1, characterized in that: The bottle cap (2) has a cross-shaped pre-cut (22) at the top.

4. The purified sample inlet vial according to claim 1, characterized in that: A retaining ring (32) is fixedly provided on the outer side of the sleeve (31) at a position away from the sealing ring (33).

5. The purified sample inlet vial according to claim 1, characterized in that: The purification packing (34) includes one or more of magnesium sulfate packing, GCB packing, PSA packing and C18 packing.

6. The purified sample inlet vial according to claim 1, characterized in that: The outer and inner diameters of the upper opening of the sleeve (31) gradually decrease from top to bottom.

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