Multi-channel SNPSTR dual-mode test reagent dispenser

Abstract

This utility model relates to the field of dispenser technology, specifically to a multi-channel SNPSTR dual-mode test reagent dispenser, comprising a main unit and a deep-hole plate slidably disposed on the main unit. A locking mechanism is fixedly disposed on the front side of the lower top surface of the deep-hole plate. The locking mechanism includes a limiting post. When the limiting post is inserted into the main unit, it restricts the deep-hole plate onto the main unit. When the limiting post is disengaged from the main unit, the main unit loses its restriction on the deep-hole plate. Pushing the lifting plate upward causes the limiting post to move upward along with the locking cylinder. The bottom end of the limiting post is higher than the upper surface of the carrier plate, thus not obstructing its forward movement. Releasing the lifting plate causes the spring to return, pushing the locking cylinder downward. The limiting post moves downward along with the locking cylinder and inserts into the limiting hole, restricting the deep-hole plate onto the carrier plate. The locking mechanism can be operated with one hand, while the other hand can push and pull the push plate to remove or install the deep-hole plate onto the carrier plate, without requiring assistance from others.

Description

Technical Field

[0001] This utility model relates to the field of dispenser technology, and in particular to a multi-channel SNPSTR dual-mode detection reagent dispenser. Background Technology

[0002] The multi-channel SNPSTR dual-mode detection reagent dispenser is a high-throughput automated device designed for forensic DNA testing, population genetics analysis, precision medicine, and other fields. It is used in forensic database construction (such as the CODIS system), tumor genotyping, and epidemic prevention and control. The 32-channel dispenser can complete the dispensing of STR reagents for 100 96-well plates within 1 hour and supports batch sample library construction. When used with NGS library construction kits, it enables automated pretreatment for SNP site detection and rapid dispensing of multiplex PCR detection reagents.

[0003] Chinese patent application CN201980010718.X describes a dispenser for discharging chemical reagents from a container coupled to a dispenser. It features an input connector within a receiving cavity for connection to a container outlet. A push rod of the input connector extends into and retracts from the container outlet. The push rod extends just before reaching the working position, particularly during the last 20% of the movement of the container holder to that position, and retracts as the container holder moves to a different position. The push rod is integrated into a container for temporary storage of the chemical reagents and moves with the container, which is designed to move toward and away from the input connector, thus actuating the push rod. As the push rod extends into the container outlet, the chemical reagents flow directly into the container via the push rod. From there, the chemical reagents are discharged by gravity or via a pump installed in the dispenser. However, this dispenser lacks a convenient locking mechanism between the perforated plate and the carrier platform, making single-handed operation impossible; assistance is required to remove the perforated plate. Summary of the Invention

[0004] The main purpose of this invention is to provide a multi-channel SNPSTR dual-mode test reagent dispenser to solve the problem in related technologies that there is no convenient locking structure between the deep well plate and the carrier stage, making it impossible to operate with one hand and requiring assistance from others when removing the deep well plate.

[0005] To achieve the above objectives, according to one aspect of the present invention, a multi-channel SNPSTR dual-mode detection reagent dispenser is provided, comprising a main unit and a deep-well plate slidably disposed on the main unit, and further comprising: a locking part, the locking part being fixedly disposed on the front side of the lower top surface of the deep-well plate, the locking part including a limiting post, wherein when the limiting post is inserted into the main unit, the deep-well plate is restricted on the main unit, and when the limiting post is disengaged from the main unit, the main unit loses its restriction on the deep-well plate.

[0006] Furthermore, the main unit includes a carrier plate assembly, a vertical plate assembly, and a top plate assembly. The carrier plate assembly includes a carrier plate, a limiting hole, and two side vertical plate assemblies. The side vertical plate assemblies are respectively disposed on both sides of the upper surface of the carrier plate. The side vertical plate assembly includes a side vertical plate and a sliding groove. The vertical plate assembly includes a vertical plate and a limiting groove. The top plate assembly includes a top plate, several wiring terminals, and several discharge nozzles.

[0007] Furthermore, the limiting hole is located on the outer side of the upper surface of the carrier plate, the side plate is fixedly located on the upper surface of the carrier plate, and the sliding groove is located on the inner side of the side plate.

[0008] Furthermore, the upright plate is fixedly installed on the rear side of the upper surface of the carrier plate, the limiting groove is located on the lower front side of the upright plate, the top plate is fixedly installed on the upper front side of the upright plate, the wiring terminals are all fixedly installed on the front side of the top plate, and the discharge nozzles are all fixedly installed on the lower surface of the top plate.

[0009] Furthermore, the deep hole plate includes a plate body assembly and several support assemblies. The plate body assembly includes a deep hole plate body, two sliding plates, a limiting plate, and a push plate. The support assemblies include a connecting plate and a limiting ring.

[0010] Furthermore, the deep hole plate is a hollow column with an open upper part. The sliding plate is fixedly installed on the lower left and right sides of the deep hole plate, the limiting plate is fixedly installed on the upper rear side of the deep hole plate, the push plate is fixedly installed on the upper front side of the deep hole plate, and the limiting ring is fixedly installed inside the upper part of the deep hole plate through the connecting plate.

[0011] Furthermore, the locking mechanism also includes a push plate assembly and a sliding assembly. The push plate assembly includes two lifting plates, two recessed grooves, several buffer balls, and several protrusions. The sliding assembly includes a locking rod, a locking cylinder, a locking ring, and a spring.

[0012] Furthermore, the locking rod is fixedly mounted on the lower surface of the push plate, the locking cylinder is slidably mounted on the bottom of the outer ring of the locking rod, the spring is located inside the locking cylinder, the top end of the spring is fixedly connected to the lower surface of the locking rod, and the bottom end is fixedly connected to the upper surface of the bottom of the locking cylinder, the locking ring is slidably mounted on the outer ring of the locking cylinder and is fixedly connected to the deep hole plate, the limiting post is fixedly mounted on the outer side of the bottom of the locking cylinder, the lifting plate is fixedly mounted on both sides of the top of the outer ring of the locking cylinder, the recessed groove is located on the lower surface of the lifting plate, the buffer balls are all fixedly mounted on the upper surface of the lifting plate, and the protrusions are all located in the recessed groove and are all fixedly connected to the lifting plate.

[0013] Compared with the prior art, this utility model has the following advantages: When the lifting plate is pushed upward, the limiting post moves upward along with the locking cylinder, and the bottom end of the limiting post is higher than the upper surface of the carrier plate, so it will not hinder the forward movement of the limiting post; when the lifting plate is released, the spring rebounds, pushing the locking cylinder downward, and the limiting post moves downward along with the locking cylinder, inserting into the limiting hole, thus restricting the deep hole plate on the carrier plate; the locking part can be operated with one hand, and the other hand can push and pull the push plate to remove the deep hole plate from the carrier plate or install it on the carrier plate, without the need for assistance from others. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall design of this utility model;

[0015] Figure 2 This is a schematic diagram of the main unit structure of this utility model;

[0016] Figure 3 This is a schematic diagram of the deep hole plate structure of this utility model;

[0017] Figure 4 This is a schematic diagram of the locking mechanism of this utility model;

[0018] Figure 5 This is a cross-sectional view of the locking part of this utility model.

[0019] Illustration:

[0020] 1. Main unit; 11. Carrier plate; 12. Vertical plate; 13. Top plate; 14. Limiting hole; 15. Side vertical plate; 16. Slide groove; 17. Wiring terminal; 18. Discharge nozzle; 19. Limiting groove;

[0021] 2. Deep hole plate section; 21. Deep hole plate body; 22. Slide plate; 23. Limiting plate; 24. Push plate; 25. Connecting plate; 26. Limiting ring;

[0022] 3. Locking part; 31. Locking upright; 32. Locking cylinder; 33. Locking ring; 34. Limiting post; 35. Lifting plate; 36. Buffer ball; 37. Recessed groove; 38. Protrusion; 39. Spring. Detailed Implementation

[0023] To further illustrate the technical means and effects adopted by this utility model in order to achieve the intended utility model purpose, the following detailed description of the specific implementation methods, structure, features and effects of this utility model is provided in conjunction with the accompanying drawings and preferred embodiments.

[0024] Please see Figures 1 to 5This embodiment provides a multi-channel SNPSTR dual-mode test reagent dispenser, including a main unit 1 and a deep well plate 2 slidably disposed on the main unit 1, and further including a locking part 3, which is fixedly disposed on the front side of the lower top surface of the deep well plate 2. The locking part 3 includes a limiting post 34. When the limiting post 34 is inserted into the main unit 1, it restricts the deep well plate 2 on the main unit 1. When the limiting post 34 is disengaged from the main unit 1, the main unit 1 loses its restriction on the deep well plate 2.

[0025] The main unit 1 includes a carrier plate assembly, a vertical plate assembly, and a top plate assembly. The carrier plate assembly includes a carrier plate 11, a limiting hole 14, and two side vertical plate assemblies. The side vertical plate assemblies are respectively located on both sides of the upper surface of the carrier plate 11. The side vertical plate assembly includes a side vertical plate 15 and a sliding groove 16. The vertical plate assembly includes a vertical plate 12 and a limiting groove 19. The top plate assembly includes a top plate 13, several wiring terminals 17, and several discharge nozzles 18.

[0026] Limiting hole 14 is provided on the outer side of the upper surface of the carrier plate 11, side plate 15 is fixedly provided on the upper surface of the carrier plate 11, and sliding groove 16 is provided on the inner side of the side plate 15.

[0027] The slide plate 22 slides within the slide groove 16, guiding the deep hole plate 21 so that it slides horizontally onto the carrier plate stage 11.

[0028] The upright plate 12 is fixedly installed on the rear side of the upper surface of the carrier plate 11, the limiting groove 19 is located on the lower front side of the upright plate 12, the top plate 13 is fixedly installed on the upper front side of the upright plate 12, the wiring terminals 17 are all fixedly installed on the front side of the top plate 13, and the discharge nozzles 18 are all fixedly installed on the lower surface of the top plate 13.

[0029] The discharge nozzle 18 contains a reagent, and a precision pneumatic pump for pumping out the reagent is fixedly installed on its top.

[0030] After the deep hole plate 21 is fully pushed into the carrier plate stage 11, the limiting plate 23 is inserted into the limiting groove 19 to fix the front end of the deep hole plate 21 on the carrier plate stage 11, preventing the front end of the deep hole plate 21 from tilting and becoming unbalanced.

[0031] The deep hole plate part 2 includes a plate body assembly and several support assemblies. The plate body assembly includes a deep hole plate body 21, two sliding plates 22, a limiting plate 23 and a push plate 24. The support assemblies include a connecting plate 25 and a limiting ring 26.

[0032] The deep hole plate 21 is a hollow column with an open upper part. The sliding plate 22 is fixedly installed on the lower left and right sides of the deep hole plate 21. The limiting plate 23 is fixedly installed on the upper rear side of the deep hole plate 21. The push plate 24 is fixedly installed on the upper front side of the deep hole plate 21. The limiting ring 26 is fixedly installed inside the upper part of the deep hole plate 21 through the connecting plate 25.

[0033] The limiting ring 26 is used to accommodate the reagent bottle.

[0034] The locking part 3 also includes a push plate assembly and a sliding assembly. The push plate assembly includes two lifting plates 35, two recessed grooves 37, several buffer balls 36 and several protrusions 38. The sliding assembly includes a locking rod 31, a locking cylinder 32, a locking ring 33 and a spring 39.

[0035] The locking rod 31 is fixedly mounted on the lower surface of the push plate 24. The locking cylinder 32 is slidably mounted on the bottom of the outer ring of the locking rod 31. The spring 39 is located inside the locking cylinder 32. The top end of the spring 39 is fixedly connected to the lower surface of the locking rod 31, and the bottom end is fixedly connected to the upper bottom surface of the locking cylinder 32. The locking ring 33 is slidably mounted on the outer ring of the locking cylinder 32 and is fixedly connected to the deep hole plate 21. The limiting post 34 is fixedly mounted on the outer bottom of the locking cylinder 32. The lifting plate 35 is fixedly mounted on both sides of the top of the outer ring of the locking cylinder 32. The recessed groove 37 is located on the lower surface of the lifting plate 35. The buffer balls 36 are all fixedly mounted on the upper surface of the lifting plate 35. The protrusions 38 are all located in the recessed groove 37 and are all fixedly connected to the lifting plate 35.

[0036] The diameter of the limiting post 34 is slightly smaller than the diameter of the limiting hole 14, ensuring that the limiting post 34 can be smoothly inserted into the limiting hole 14 without shaking.

[0037] The recessed groove 37 is used to accommodate fingers and prevent them from sliding on the lifting plate 35 and being unable to push the lifting plate 35 up. The protrusions 38 increase the friction between the fingers and the lifting plate 35, making it easier to push the lifting plate 35 up. The buffer ball 36 is made of rubber to reduce the impact of the lifting plate 35 on the push plate 24 and improve the comfort of the hand.

[0038] Insert the reagent bottle into the corresponding limiting ring 26 so that the bottom of the reagent bottle contacts the bottom of the deep hole plate 21 to prevent the reagent bottle from tipping over; lift the deep hole plate 2 containing the reagent bottle so that the limiting plate 23 faces inward and the sliding plate 22 is located in the corresponding sliding groove 16; push the deep hole plate 2 forward and insert it into the carrier plate 11 from the front end; when the locking part 3 is about to touch the edge of the carrier plate 11, put the middle and index fingers into the recessed grooves 37 respectively and push the lifting plate 35 upward; the lifting plate 35 drives the locking cylinder 32 to slide upward along the locking ring 33, and the spring 39 is... When squeezed, the limiting post 34 moves upward along with the locking cylinder 32. When the buffer ball 36 touches the lower surface of the push plate 24, the bottom of the limiting post 34 is higher than the upper surface of the carrier plate 11, which will not hinder the forward movement of the limiting post 34. When the limiting plate 23 is fully inserted into the limiting groove 19, the limiting post 34 is just located on the upper surface of the limiting hole 14. When the lifting plate 35 is released, the spring 39 rebounds and pushes the locking cylinder 32 downward. The limiting post 34 moves downward along with the locking cylinder 32 and is inserted into the limiting hole 14, thus restricting the deep hole plate 2 on the carrier plate 11.

[0039] Connect the reagent bottles to the dispensing nozzles 18 using hoses. Start the precision air pump at the top of the dispensing nozzles 18 to pump the reagents from the dispensing nozzles 18 into the reagent bottles through the hoses. When it is necessary to remove the deep hole plate 2, push the lifting plate 35 upward to pull the limiting post 34 out of the limiting hole 14. While maintaining the upward pushing action of the lifting plate 35, pull the push plate 24 outward to pull it off the carrier plate stage 11.

[0040] The precision pneumatic pump of the multi-channel SNP / STR distributor is a hybrid system of pneumatic (STR) and piezoelectric (SNP), which achieves "dual mode in one machine" through intelligent switching, reducing reliance on mechanical power.

[0041] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present utility model. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A multi-channel SNP STR dual-mode detection reagent dispenser comprising a main body (1) and a deep-well plate body (2) slidingly arranged on the main body (1), characterized in that, Also includes: The locking part (3) is fixedly disposed on the front side of the lower top surface of the deep hole plate part (2). The locking part (3) includes a limiting post (34). When the limiting post (34) is inserted into the main unit (1), it restricts the deep hole plate part (2) on the main unit (1). When the limiting post (34) is removed from the main unit (1), the main unit (1) loses its restriction on the deep hole plate part (2).

2. The multi-channel SNP STR dual-mode test reagent dispenser according to claim 1, characterized in that, The main unit (1) includes a carrier plate assembly, a vertical plate assembly, and a top plate assembly. The carrier plate assembly includes a carrier plate (11), a limiting hole (14), and two side vertical plate assemblies. The side vertical plate assemblies are respectively located on both sides of the upper surface of the carrier plate (11). The side vertical plate assembly includes a side vertical plate (15) and a sliding groove (16). The vertical plate assembly includes a vertical plate (12) and a limiting groove (19). The top plate assembly includes a top plate (13), several wiring terminals (17), and several discharge nozzles (18).

3. The multi-channel SNP STR dual-mode test reagent dispenser of claim 2, wherein, The limiting hole (14) is located on the outer side of the upper surface of the carrier plate (11), the side plate (15) is fixedly located on the upper surface of the carrier plate (11), and the sliding groove (16) is located on the inner side of the side plate (15).

4. The multi-channel SNP STR dual-mode test reagent dispenser of claim 2, wherein, The upright plate (12) is fixedly installed on the rear side of the upper surface of the carrier plate (11), the limiting groove (19) is located below the front side of the upright plate (12), the top plate (13) is fixedly installed above the front side of the upright plate (12), the wiring terminals (17) are all fixedly installed on the front side of the top plate (13), and the discharge nozzles (18) are all fixedly installed on the lower surface of the top plate (13).

5. The multi-channel SNP STR dual-mode test reagent dispenser of claim 1, wherein, The deep hole plate (2) includes a plate body assembly and several support assemblies. The plate body assembly includes a deep hole plate body (21), two sliding plates (22), a limiting plate (23), and a push plate (24). The support assemblies include a connecting plate (25) and a limiting ring (26).

6. The multi-channel SNP STR dual-mode test reagent dispenser of claim 5, wherein, The deep hole plate (21) is a hollow column with an open upper part. The sliding plate (22) is fixedly installed on the lower left and right sides of the deep hole plate (21). The limiting plate (23) is fixedly installed on the upper rear side of the deep hole plate (21). The push plate (24) is fixedly installed on the upper front side of the deep hole plate (21). The limiting ring (26) is fixedly installed inside the upper part of the deep hole plate (21) through the connecting plate (25).

7. The multi-channel SNP STR dual-mode test reagent dispenser of claim 5, wherein, The locking part (3) also includes a push plate assembly and a sliding assembly. The push plate assembly includes two lifting plates (35), two recessed grooves (37), several buffer balls (36) and several protrusions (38). The sliding assembly includes a locking rod (31), a locking cylinder (32), a locking ring (33) and a spring (39).

8. The multi-channel SNP STR dual-mode test reagent dispenser of claim 7, wherein, The locking rod (31) is fixedly mounted on the lower surface of the push plate (24). The locking cylinder (32) is slidably mounted on the bottom of the outer ring of the locking rod (31). The spring (39) is located inside the locking cylinder (32). The top end of the spring (39) is fixedly connected to the lower surface of the locking rod (31), and the bottom end is fixedly connected to the upper surface of the bottom of the locking cylinder (32). The locking ring (33) is slidably mounted on the outer ring of the locking cylinder (32) and is connected to the deep hole plate. The body (21) is fixedly connected, the limiting post (34) is fixedly installed on the bottom outside of the locking cylinder (32), the lifting plate (35) is fixedly installed on both sides of the top of the outer ring of the locking cylinder (32), the recessed groove (37) is installed on the lower surface of the lifting plate (35), the buffer ball (36) is fixedly installed on the upper surface of the lifting plate (35), and the protrusion (38) is located in the recessed groove (37) and is fixedly connected to the lifting plate (35).

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