Chromatographic liquid concentration kettle for producing glabridin

Abstract

This utility model discloses a chromatography concentrate for the production of glycyrrhizin, relating to the field of chemical pharmaceutical technology. The utility model includes several support legs, with a heat insulation plate fixedly connected to the top outer wall of each support leg. A concentrate is fixedly connected to the inner wall of the heat insulation plate, with an exhaust pipe and a feed pipe fixedly connected to the inner wall of the concentrate. A filtration mechanism is provided on the inner wall of the concentrate. This utility model utilizes a protrusion and a spring. When the protrusion rotates, it compresses a U-shaped rod, causing the U-shaped rod to slide in a circular groove. As the U-shaped rod moves, it compresses the spring, causing the U-shaped rod to move along with the filter plate. When the protrusion is not in contact with the U-shaped rod, the spring compresses the U-shaped rod, causing it to reset. The filter plate then resets along with the U-shaped rod. This improves product purity, effectively prevents solid particles from being present in the chromatography solution, avoids mixing of fixed particles in the chromatography solution with glycyrrhizin, and ensures a purer final product.

Description

Technical Field

[0001] This utility model belongs to the field of chemical pharmaceutical technology, and in particular relates to a chromatography concentrate concentrator for the production of glycyrrhizin. Background Technology

[0002] Glycyrrhizin, a highly valuable natural active ingredient, is widely used in the pharmaceutical and cosmetic fields. In medicine, it exhibits potential medicinal effects such as anti-inflammation, anti-oxidation, and antiviral properties; in cosmetics, it is highly favored for its excellent whitening, spot-removing, and anti-wrinkle effects.

[0003] Existing equipment produces insoluble solids in the chromatography solvent due to chemical reactions when the solvent is added. These solids mix with glycyrrhizin during use, resulting in impurities in the subsequent glycyrrhizin production. Therefore, we propose a chromatography solvent concentration vessel for glycyrrhizin production. Utility Model Content

[0004] The purpose of this invention is to provide a chromatography concentrate for the production of glycyrrhizin. Through a filtration mechanism and a stirring mechanism, it solves the problem that in existing equipment, when the chromatography solution is added, insoluble solid substances are generated in the chromatography solution due to chemical reactions. When the chromatography solution is used, the solid substances in the chromatography solution mix with glycyrrhizin, resulting in impurities in the subsequent glycyrrhizin production.

[0005] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0006] This utility model is a chromatography solvent concentration vessel for the production of glycyrrhizin, comprising several support legs, an insulation plate fixedly connected to the top outer wall of the support legs, a concentration vessel fixedly connected to the inner wall of the insulation plate, an exhaust pipe fixedly connected to the inner wall of the concentration vessel, a feed pipe fixedly connected to the inner wall of the concentration vessel, and a filtration mechanism provided on the inner wall of the concentration vessel.

[0007] The filtration mechanism includes an inlet pipe, the outer wall of which is fixedly connected to the inner wall of the concentration vessel. A mounting bracket is fixedly connected to the top outer wall of the insulation plate. A first motor is fixedly connected to the inner wall of the mounting bracket. A rotating shaft is fixedly connected to the bottom output shaft of the first motor via a coupling. A pulley is fixedly connected to the outer wall of the rotating shaft. A belt is driven through the outer wall of the pulley. A fixing frame is fixedly connected to the top outer wall of the insulation plate. A roller is rotatably connected to the inner wall of the fixing frame. A pulley is fixedly connected to the outer wall of the roller.

[0008] Furthermore, the outer wall of the pulley is connected to the inner wall of the belt, a protrusion is fixedly connected to the outer wall of the roller away from the fixed frame, a fixing block is fixedly connected to the outer wall of the liquid inlet pipe, a circular groove is opened on the inner wall of the fixing block, a U-shaped rod is slidably connected to the inner wall of the circular groove, a spring is fixedly connected to the outer wall of the U-shaped rod, a filter plate is fixedly connected to the outer wall of the U-shaped rod, the outer wall of the filter plate is slidably connected to the inner wall of the liquid inlet pipe, and a stirring mechanism is provided on the outer wall of the concentration vessel.

[0009] Furthermore, the stirring mechanism includes several heating plates, the outer walls of which are fixedly connected to the outer wall of the concentration vessel. A crown gear is fixedly connected to the outer wall of the rotating shaft on the side away from the first motor. A stirring rod is rotatably connected to the inner wall of the concentration vessel. A gear is fixedly connected to the outer wall of the stirring rod near the crown gear, and the outer wall of the gear meshes with the outer wall of the crown gear.

[0010] Furthermore, an installation frame is fixedly connected to the outer wall of the stirring rod, and a circular hole is provided on the inner wall of the installation frame.

[0011] Furthermore, a fixing rod is slidably connected to the inner wall of the circular hole, and a scraper is fixedly connected to the outer wall of the fixing rod on the side away from the stirring rod.

[0012] Furthermore, the outer wall of the mounting frame is fixedly connected with several support plates, and the inner wall of the support plates is provided with circular holes.

[0013] Furthermore, a limiting rod is slidably connected to the inner wall of the circular hole, and a spring is fixedly connected to the outer wall of the limiting rod.

[0014] Furthermore, a bearing seat is fixedly connected to the outer wall of the limiting rod on the side away from the support plate, a connecting plate is rotatably connected to the outer wall of the bearing seat, a second bearing seat is rotatably connected to the inner wall of the connecting plate, the outer wall of the second bearing seat is fixedly connected to the outer wall of the scraper, a discharge pipe is fixedly connected to the inner wall of the concentration vessel, and a butterfly valve is rotatably connected to the inner wall of the discharge pipe.

[0015] This utility model has the following beneficial effects:

[0016] 1. This utility model incorporates a protrusion and a spring. When the protrusion rotates, it squeezes the U-shaped rod, causing it to slide in the circular groove. As the U-shaped rod moves, it squeezes the spring, which in turn moves the filter plate along with it. When the protrusion is not in contact with the U-shaped rod, the spring squeezes the rod, causing it to reset. The filter plate then resets along with the U-shaped rod. This design improves product purity, effectively prevents solid particles from being present in the chromatography solvent, and avoids mixing of fixed particles in the chromatography solvent with gluconol, resulting in purer gluconol in the subsequent chromatography.

[0017] 2. This utility model incorporates a stirring rod and a scraper. When the stirring rod rotates, it causes the mounting frame to rotate as well. The mounting frame then moves the fixing rod, which in turn moves the scraper, cleaning the material from the inner wall of the concentration vessel. Simultaneously, the spring compresses the limiting rod, causing it to move inward. This movement of the limiting rod also moves the shaft seat, accelerating heat transfer. The stirring process ensures more uniform heating of the chromatography solution, preventing excessively high temperatures on the outer side of the solution that could lead to adverse reactions with gluconate.

[0018] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0021] Figure 2 This is a cross-sectional view of the overall structure of this utility model;

[0022] Figure 3 This is a cross-sectional view of the pulley structure of this utility model;

[0023] Figure 4 This is a cross-sectional view of the rotating rod structure of this utility model;

[0024] Figure 5 This utility model Figure 4 Enlarged view of point A in the middle.

[0025] The attached diagram lists the components represented by each number as follows:

[0026] 1. Support leg; 101. Insulation plate; 102. Concentrator; 103. Exhaust pipe; 104. Feed pipe; 2. Filtration mechanism; 201. Liquid inlet pipe; 202. Mounting bracket; 203. First motor; 204. Rotating shaft; 205. Pulley; 206. Belt; 207. Fixing bracket; 208. Roller; 209. Belt pulley; 210. Protrusion; 211. Fixing block; 212. Circular groove; 213. Spring; 214. U 215. Stirring mechanism; 301. Heating plate; 302. Crown gear; 303. Stirring rod; 304. Gear; 305. Mounting frame; 306. Round hole; 307. Fixing rod; 308. Scraper; 309. Support plate; 310. Round hole; 311. Limiting rod; 312. Spring II; 313. Shaft seat; 314. Connecting plate; 315. Shaft seat II; 316. Discharge pipe; 317. Butterfly valve. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0028] Please see Figure 1-5As shown, this utility model is a chromatography concentrate concentrator for the production of glycyrrhizin, comprising several support legs 1. A heat insulation plate 101 is fixedly connected to the top outer wall of each support leg 1. A concentration vessel 102 is fixedly connected to the inner wall of the heat insulation plate 101. An exhaust pipe 103 is fixedly connected to the inner wall of the concentration vessel 102. An inlet pipe 104 is fixedly connected to the inner wall of the concentration vessel 102, through which water vapor is discharged. A filter mechanism 2 is provided on the inner wall of the concentration vessel 102, including an inlet pipe 201. The outer wall of the inlet pipe 201 is fixedly connected to the inner wall of the concentration vessel 102. A mounting bracket 202 is fixedly connected to the top outer wall of the heat insulation plate 101. A first motor 203 is fixedly connected to the inner wall of component 202. When the operator starts the first motor 203, the bottom output shaft of the first motor 203 is fixedly connected to a rotating shaft 204 via a coupling. A pulley 205 is fixedly connected to the outer wall of the rotating shaft 204, and a belt 206 is driven through the outer wall of the pulley 205. After the first motor 203 starts, it drives the rotating shaft 204 to rotate, and then the pulley 205 rotates with the rotating shaft 204. As the pulley 205 rotates, it drives the belt 206 to move, thus realizing the transfer of kinetic energy between the components. A fixing frame 207 is fixedly connected to the top outer wall of the insulation plate 101, and a roller 208 is rotatably connected to the inner wall of the fixing frame 207. A pulley 209 is fixedly connected to the outer wall of shaft 208. The outer wall of pulley 209 is connected to the inner wall of belt 206. When belt 206 moves, it drives pulley 209 to rotate, and then pulley 209 drives roller 208 to rotate, completing the kinetic energy transfer between parts. A protrusion 210 is fixedly connected to the outer wall of roller 208 on the side away from the fixed frame 207. A fixing block 211 is fixedly connected to the outer wall of liquid inlet pipe 201. A circular groove 212 is opened on the inner wall of fixing block 211. A U-shaped rod 214 is slidably connected to the inner wall of circular groove 212. When roller 208 rotates, it drives protrusion 210 to rotate. When protrusion 210 rotates, it squeezes U-shaped rod 214. 4. The U-shaped rod 214 is moved so that when one part moves, other parts also move. When the U-shaped rod 214 slides in the circular groove 212, it will not wobble from side to side, keeping it moving horizontally. A spring 213 is fixedly connected to the outer wall of the U-shaped rod 214, and a filter plate 215 is fixedly connected to the outer wall of the U-shaped rod 214. The outer wall of the filter plate 215 is slidably connected to the inner wall of the liquid inlet pipe 201. A stirring mechanism 3 is provided on the outer wall of the concentration vessel 102. When the U-shaped rod 214 moves, it will move the filter plate 215 with it. Then the filter plate 215 filters the chromatography liquid to prevent the chromatography liquid from containing chemical particles.

[0029] The stirring mechanism 3 includes several heating plates 301, model JRD-G25, which have good flexibility and mechanical pressure resistance, a wide temperature range, and can operate normally in environments from -60℃ to 250℃. The outer walls of the heating plates 301 are fixedly connected to the outer wall of the concentration vessel 102. A crown gear 302 is fixedly connected to the outer wall of the rotating shaft 204 away from the first motor 203. A stirring rod 303 is rotatably connected to the inner wall of the concentration vessel 102. A gear 304 is fixedly connected to the outer wall of the stirring rod 303 near the crown gear 302. When the rotating shaft 204 rotates, it will drive the crown gear 302 to rotate, and then the crown gear 302 will drive the gear 304 to rotate. When gear 304 rotates, it drives the stirring rod 303 to rotate as well. The rotation of the stirring rod 303 ensures that the chromatography solution is heated evenly. The outer wall of gear 304 meshes with the outer wall of crown gear 302. A mounting frame 305 is fixedly connected to the outer wall of the stirring rod 303. When the stirring rod 303 rotates, it drives the mounting frame 305 to rotate as well, thus realizing the kinetic energy transfer between the parts. A circular hole 306 is opened on the inner wall of the mounting frame 305. A fixing rod 307 is slidably connected to the inner wall of the circular hole 306. A scraper 308 is fixedly connected to the outer wall of the fixing rod 307 on the side away from the stirring rod 303. When the fixing rod 307 slides in the circular hole 306, the fixing rod 307 will not move left or right, thus keeping the fixing rod 307 in a horizontal position.

[0030] Several support plates 309 are fixedly connected to the outer wall of the mounting frame 305. A circular hole 310 is formed in the inner wall of each support plate 309. A limit rod 311 is slidably connected to the inner wall of the circular hole 310. When the limit rod 311 slides in the circular hole 310, it will maintain horizontal movement to prevent wobbling. A spring 312 is fixedly connected to the outer wall of the limit rod 311. A bearing 313 is fixedly connected to the outer wall of the limit rod 311 on the side away from the support plate 309. A connecting plate 314 is rotatably connected to the outer wall of the bearing 313. When… When spring 312 is squeezed on limit rod 311, spring 312 will not be misaligned, thus maintaining normal operation. The inner wall of connecting plate 314 is rotatably connected to bearing seat 315, and the outer wall of bearing seat 315 is fixedly connected to the outer wall of scraper 308. The inner wall of concentration vessel 102 is fixedly connected to discharge pipe 316, and the inner wall of discharge pipe 316 is rotatably connected to butterfly valve 317. After material processing is completed, butterfly valve 317 can be opened, and then material will flow out from discharge pipe 316, making it convenient for operators to control the discharge of material.

[0031] One specific application of this embodiment is:

[0032] When the operator needs to use the equipment, firstly, place the sclerotinib and the chromatography solvent into the concentration vessel 102 through the liquid inlet pipe 201 and the feed pipe 104, respectively. Simultaneously, the first motor 203 can be started when the materials and chromatography solvent are added. After the first motor 203 starts, it will drive the rotating shaft 204 to rotate. Then, the rotating shaft 204 will drive the pulley 205 to rotate. When the pulley 205 rotates, it will drive the belt pulley 209 to rotate via the belt 206. Then, the roller 208 will rotate with the belt pulley 209. When the roller 208 rotates, it will drive the protrusion 210 to rotate. When the protrusion 210 rotates, it will squeeze the U-shaped rod 214. The U-shaped rod 214 slides in the circular groove 212. As the U-shaped rod 214 moves, it compresses the spring 213. The U-shaped rod 214 then moves the filter plate 215. When the protrusion 210 is not in contact with the U-shaped rod 214, the spring 213 compresses the U-shaped rod 214, causing it to reset. The filter plate 215 then resets along with the U-shaped rod 214. The movement of the filter plate 215 filters the chromatography solvent, preventing fixed particles in the chromatography solvent from mixing with the glufosinate. The filtered chromatography solvent and glufosinate then fall into the concentration vessel 102. Simultaneously, the heating plate 301 is activated. The concentration vessel 102 is heated to rapidly evaporate the water in the sclerotinib and chromatography solvent. The evaporated water is then discharged from the exhaust pipe 103. Simultaneously, the rotation of the rotating shaft 204 drives the crown gear 302, which in turn drives the gear 304. The gear 304, in turn, drives the stirring rod 303, which stirs the chromatography solvent and sclerotinib, ensuring more even heating. Simultaneously, the rotation of the stirring rod 303 drives the mounting frame 305, which in turn moves the fixing rod 307. During operation, the scraper 308 moves, cleaning the material on the inner wall of the concentration vessel 102. Simultaneously, spring 312 presses the limiting rod 311, causing it to move inward. As the limiting rod 311 moves, it moves the bearing 313, which in turn moves the connecting plate 314 in an arc motion. At the same time, bearing 315 moves along with the connecting plate 314, and bearing 315 moves the scraper 308, keeping it in constant contact with the inner wall of the concentration vessel 102. Once the water has completely evaporated, the butterfly valve 317 can be opened, allowing the essence of the material to be discharged from the outlet pipe 316.

[0033] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0034] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A chromatography concentrate concentrator for the production of glycyrrhizin, comprising several support legs (1), characterized in that: A heat insulation plate (101) is fixedly connected to the top outer wall of the support leg (1), a concentration vessel (102) is fixedly connected to the inner wall of the heat insulation plate (101), an exhaust pipe (103) is fixedly connected to the inner wall of the concentration vessel (102), a feed pipe (104) is fixedly connected to the inner wall of the concentration vessel (102), and a filter mechanism (2) is provided on the inner wall of the concentration vessel (102). The filtration mechanism (2) includes an inlet pipe (201), the outer wall of which is fixedly connected to the inner wall of the concentration vessel (102). The top outer wall of the insulation plate (101) is fixedly connected to a mounting bracket (202), and the inner wall of the mounting bracket (202) is fixedly connected to a first motor (203). The bottom output shaft of the first motor (203) is fixedly connected to a rotating shaft (204) via a coupling. The outer wall of the rotating shaft (204) is fixedly connected to a pulley (205), and the outer wall of the pulley (205) is connected to a belt (206). The top outer wall of the insulation plate (101) is fixedly connected to a fixing frame (207), and the inner wall of the fixing frame (207) is rotatably connected to a roller (208). The outer wall of the roller (208) is fixedly connected to a pulley (209).

2. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 1, characterized in that, The outer wall of the pulley (209) is connected to the inner wall of the belt (206). A protrusion (210) is fixedly connected to the outer wall of the roller (208) away from the fixed frame (207). A fixing block (211) is fixedly connected to the outer wall of the liquid inlet pipe (201). A circular groove (212) is opened on the inner wall of the fixing block (211). A U-shaped rod (214) is slidably connected to the inner wall of the circular groove (212). A spring (213) is fixedly connected to the outer wall of the U-shaped rod (214). A filter plate (215) is fixedly connected to the outer wall of the U-shaped rod (214). The outer wall of the filter plate (215) is slidably connected to the inner wall of the liquid inlet pipe (201). A stirring mechanism (3) is provided on the outer wall of the concentration vessel (102).

3. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 2, characterized in that, The stirring mechanism (3) includes several heating plates (301), the outer walls of which are fixedly connected to the outer wall of the concentration vessel (102). The outer wall of the rotating shaft (204) away from the first motor (203) is fixedly connected to a crown gear (302). The inner wall of the concentration vessel (102) is rotatably connected to a stirring rod (303). The outer wall of the stirring rod (303) near the crown gear (302) is fixedly connected to a gear (304), and the outer wall of the gear (304) meshes with the outer wall of the crown gear (302).

4. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 3, characterized in that, The outer wall of the stirring rod (303) is fixedly connected to the mounting frame (305), and the inner wall of the mounting frame (305) is provided with a round hole (306).

5. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 4, characterized in that, A fixing rod (307) is slidably connected to the inner wall of the circular hole (306), and a scraper (308) is fixedly connected to the outer wall of the fixing rod (307) away from the stirring rod (303).

6. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 5, characterized in that, The outer wall of the mounting frame (305) is fixedly connected with several support plates (309), and the inner wall of the support plates (309) is provided with round holes (310).

7. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 6, characterized in that, The inner wall of the circular hole (310) is slidably connected to a limiting rod (311), and the outer wall of the limiting rod (311) is fixedly connected to a spring (312).

8. The chromatography solvent concentration vessel for the production of glycyrrhizin according to claim 7, characterized in that, The limiting rod (311) is fixedly connected to a bearing seat (313) on the outer wall away from the support plate (309). The outer wall of the bearing seat (313) is rotatably connected to a connecting plate (314). The inner wall of the connecting plate (314) is rotatably connected to a bearing seat two (315). The outer wall of the bearing seat two (315) is fixedly connected to the outer wall of the scraper (308). The inner wall of the concentration vessel (102) is fixedly connected to a discharge pipe (316). The inner wall of the discharge pipe (316) is rotatably connected to a butterfly valve (317).

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