Chromatography medium solid-liquid separation device

Abstract

The utility model discloses a chromatography medium solid -liquid separation device, including the lower sleeve, rotary lifting filter assembly and upper sleeve from below and upwards are connected in proper order, rotary lifting filter assembly includes filter sleeve and rotation ring, filter sleeve is inserted on the lower sleeve along the axial direction, and can slide along the axial direction to the lower sleeve, and the bottom wall of filter sleeve and the bottom wall of the inner chamber of lower sleeve form recovery chamber, rotation ring is set up in the outside of lower sleeve, and is overlapped with the annular protrusion of lower sleeve outer wall setting, and the inner wall of rotation ring and filter sleeve swing joint, wherein, when rotation ring rotates, filter sleeve can reciprocatingly move along the axial direction, the upper sleeve is detachably connected with the lower sleeve, and the lower end surface is in contact with rotation ring, and is built -in and extends to the stirring subassembly of filter sleeve inside. The utility model discloses through above -mentioned setting, can effectively shorten the time -length that the time that the filling material dewatering needs spends is consumed.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceuticals, and in particular to a solid-liquid separation device for chromatography media. Background Technology

[0002] In biopharmaceutical and molecular biology laboratories, dextran gels are commonly used for the dehydration of chromatographic media. For example, in the separation and purification of biomacromolecules such as proteins and nucleic acids, dextran gels, as a commonly used chromatographic medium, require dehydration using a solid-liquid separation device before use to achieve optimal performance.

[0003] In existing technologies, solid-liquid separation devices typically include a lower sleeve, a filter screen, and an upper sleeve with a built-in stirring assembly, arranged sequentially from bottom to top. The centrifugal force generated by the stirring assembly, combined with the use of a dehydrating agent, allows the dewatering packing material on the filter screen to effectively undergo dehydration, thus achieving solid-liquid separation. However, these devices have certain drawbacks: for example, the filter screens in existing technologies are mostly fixed, meaning that the dewatering process mainly relies on the weight of the dewatering packing material and the stirring action to filter water. This results in a long processing time, making it difficult to meet the time-sensitive application requirements in experimental scenarios.

[0004] Therefore, a chromatographic medium solid-liquid separation device is needed to solve the above problems. Utility Model Content

[0005] The purpose of this invention is to provide a solid-liquid separation device for chromatography media, which can effectively shorten the time required for dehydrating the packing material, so as to meet the time-sensitive application requirements in the laboratory.

[0006] To solve the above-mentioned technical problems, this utility model provides a solid-liquid separation device for chromatography media, including a lower sleeve, a rotary lifting filter assembly and an upper sleeve connected in sequence from bottom to top;

[0007] The rotary lifting filter assembly includes a filter sleeve and a rotating ring;

[0008] The filter sleeve is inserted into the lower sleeve along the axial direction and can slide relative to the lower sleeve along the axial direction, and a recovery chamber is formed between the bottom wall of the filter sleeve and the bottom wall of the inner cavity of the lower sleeve.

[0009] The rotating ring is sleeved on the outside of the lower sleeve and overlaps with the annular protrusion provided on the outer wall of the lower sleeve, and the inner wall of the rotating ring is movably connected to the filter sleeve.

[0010] When the rotating ring rotates, the filter sleeve can reciprocate along the axial direction;

[0011] The upper sleeve and the lower sleeve are detachably connected, and the lower end face contacts the rotating ring, and a stirring assembly extending into the interior of the filter sleeve is built in.

[0012] Furthermore, an annular groove is provided on the inner wall of the rotating ring, and a limiting post matching the annular groove is provided on the outer wall of the filter sleeve.

[0013] When the filter sleeve is inserted into the lower sleeve, the limiting post moves only along the axial direction of the filter sleeve.

[0014] The annular groove includes multiple staggered and smoothly connected trough segments and crest segments;

[0015] When the rotating ring rotates, causing the limiting post to move from the trough section to the crest section, the filter sleeve rises along the axial direction;

[0016] When the rotating ring rotates, causing the limiting post to move from the crest section to the trough section, the filter sleeve descends along the axial direction.

[0017] Furthermore, both sides of the upper end face of the lower sleeve are provided with limiting grooves that match the limiting post.

[0018] Furthermore, when the filter sleeve reciprocates relative to the lower sleeve along the axial direction, the stirring assembly is always located inside the filter sleeve.

[0019] Furthermore, this also includes drive components;

[0020] The drive component is detachably connected to the rotating ring and is used to control the rotation around its axis.

[0021] Furthermore, the driving component includes a drive motor with a bevel gear fixedly mounted on its output end and a bevel gear ring;

[0022] The drive motor is mounted on the annular protrusion;

[0023] The bevel gear ring is fixedly installed on the outer wall of the rotating ring and meshes with the bevel gear.

[0024] Furthermore, when the rotating ring moves along the axial direction, the bevel ring and the bevel gear can separate.

[0025] Furthermore, the top of the upper sleeve is provided with a feed inlet.

[0026] Furthermore, the upper sleeve and the lower sleeve are connected by threads.

[0027] Furthermore, the inner wall of the upper sleeve is provided with an internal thread, and the outer wall of the lower sleeve is provided with an external thread, so that the lower end face of the upper sleeve can contact the rotating ring for limiting the rotation ring.

[0028] Compared with the prior art, the present invention has at least the following beneficial effects:

[0029] By configuring a rotating and lifting filter assembly including a filter sleeve and a rotating ring, and enabling the filter sleeve to reciprocate along its axis as the rotating ring rotates, the lifting and lowering of the filter sleeve enhances the dispersion effect on the dewatering packing material, thereby improving its mixing with the dewatering agent and accelerating dewatering. Furthermore, during the lifting and lowering process, the filter sleeve periodically applies dynamic shaking to the dewatering packing material to accelerate water separation, effectively shortening the dewatering time required to meet the time-sensitive application requirements in laboratories. Attached Figure Description

[0030] Figure 1 This is a cross-sectional view of the chromatographic medium solid-liquid separation device in Embodiment 1 of this utility model when the limiting column is located in the trough section;

[0031] Figure 2 This is a cross-sectional view of the chromatographic medium solid-liquid separation device in Embodiment 1 of this utility model when the limiting column is located in the crest section;

[0032] Figure 3 This is an exploded view of the solid-liquid separation device for chromatography media in Embodiment 1 of this utility model;

[0033] Figure 4 This is a cross-sectional view of the limiting column of the chromatography medium solid-liquid separation device in Embodiment 2 of this utility model when it is located in the crest section.

[0034] Reference numerals: 1. Lower sleeve; 11. Annular protrusion; 12. Limiting groove; 2. Rotary lifting filter assembly; 21. Filter sleeve; 22. Rotating ring; 3. Upper sleeve; 31. Stirring assembly; 32. Feed inlet; 5. Annular groove; 51. Valley section; 52. Crest section; 6. Limiting post; 7. Driving component; 71. Bevel gear; 72. Drive motor; 73. Bevel gear ring. Detailed Implementation

[0035] The chromatographic medium solid-liquid separation device of this utility model will now be described in more detail with reference to the schematic diagrams, which illustrate preferred embodiments of this utility model. It should be understood that those skilled in the art can modify the utility model described herein while still achieving the advantageous effects of this utility model. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit this utility model.

[0036] Furthermore, based on the teachings of this specification, those skilled in the art can form new technical solutions through cross-combination of different implementation methods without creating technical contradictions. Such variations should all be considered to fall within the protection scope of this patent.

[0037] The present invention will be described in more detail below by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0038] Example 1

[0039] like Figures 1 to 3 As shown in the figure, this utility model embodiment proposes a solid-liquid separation device for chromatography media, including a lower sleeve 1, a rotary lifting filter assembly 2, and an upper sleeve 3 connected sequentially from bottom to top.

[0040] The rotary lifting filter assembly 2 includes a filter sleeve 21 and a rotating ring 22.

[0041] The filter sleeve 21 is inserted into the lower sleeve 1 along the axial direction and can slide relative to the lower sleeve 1 along the axial direction. By controlling the movement of the filter sleeve 21, a dynamic shaking effect can be applied to the dehydration packing located inside it to accelerate the separation of water, thereby shortening the time required to dehydrate the packing.

[0042] A recovery chamber is formed between the bottom wall of the filter sleeve 21 and the inner bottom wall of the lower sleeve 1 for centralized recovery of filtered water.

[0043] In this embodiment, the rotating ring 22 is sleeved on the outside of the lower sleeve 1 and overlaps with the annular protrusion 11 provided on the outer wall of the lower sleeve 1, and the inner wall of the rotating ring 22 is movably connected to the filter sleeve 21.

[0044] It should be noted that when the rotating ring 22 rotates, the filter sleeve 21 can reciprocate along the axial direction. That is, through the connection between the rotating ring 22 and the filter sleeve 21, and by means of the limiting relationship formed when the filter sleeve 21 is inserted into the lower sleeve 1, the rotating ring 22 can drive the filter sleeve 21 to reciprocate along the axial direction when rotating, thereby realizing the shaking of the dewatering packing material located in the filter sleeve 21 and accelerating the separation of moisture.

[0045] The upper sleeve 3 is detachably connected to the lower sleeve 1, and its lower end face contacts the rotating ring 22. This allows the upper sleeve 3 and lower sleeve 1 to work together with the annular protrusion 11 to form a positioning gap. Since the upper sleeve 3 only contacts the rotating ring 22 and is not pressed tightly against it, the rotating ring 22 can rotate within this positioning gap, thus achieving the reciprocating lifting control function of the filter sleeve 21.

[0046] In this embodiment, the upper sleeve 3 has a stirring component 31 that extends into the filter sleeve 21. The stirring component 31 agitates the filter sleeve 21 to accelerate the mixing effect of the dehydrated packing and dehydrating agent.

[0047] When the stirring component 31 is disturbed, the rotating ring 22 can be rotated so that the dewatering packing at different heights can contact the blades of the stirring component 31 to improve the effect of disturbance and dispersion, thereby improving the mixing effect of the dewatering packing and the dehydrating agent and achieving the purpose of accelerating dehydration.

[0048] This device employs a rotating and lifting filter assembly 2, comprising a filter sleeve 21 and a rotating ring 22. As the rotating ring 22 rotates, the filter sleeve 21 reciprocates along its axis. When the stirring assembly 31 within the upper sleeve 3 is operating, the lifting and lowering of the filter sleeve 21 enhances the dispersion of the dewatering packing material, thereby improving its mixing with the dewatering agent and accelerating dewatering. Furthermore, during the lifting and lowering process, the filter sleeve 21 periodically applies dynamic shaking to the dewatering packing material to accelerate water separation, effectively shortening the dewatering time required and meeting the time-sensitive application requirements in laboratories.

[0049] In this embodiment, the connection between the rotating ring 22 and the filter sleeve 21 is further explained so that the reciprocating movement of the filter sleeve 21 in its axial direction can be better achieved by rotating the rotating ring 22.

[0050] Specifically, the inner wall of the rotating ring 22 is provided with an annular groove 5, and the outer wall of the filter sleeve 21 is provided with a limiting post 6 that matches the annular groove 5.

[0051] It should be noted that when the filter sleeve 21 is inserted into the lower sleeve 1, the limiting post 6 moves only along the axial direction of the filter sleeve 21 to ensure that the filter sleeve 21 does not rotate synchronously with the rotating ring 22 when the rotating ring 22 rotates.

[0052] In this embodiment, the annular groove 5 includes multiple staggered and smoothly connected trough segments 51 and crest segments 52.

[0053] Specifically, when the rotating ring 22 rotates, causing the limiting post 6 to move from the trough section 51 to the crest section 52, the filter sleeve 21 rises along the axial direction; conversely, when the rotating ring 22 rotates, causing the limiting post 6 to move from the crest section 52 to the trough section 51, the filter sleeve 21 descends along the axial direction. This allows the limiting post 6 to reciprocate between the trough section 51 and the crest section 52 as the rotating ring 22 rotates in a predetermined direction, thereby achieving the function of reciprocating movement of the filter sleeve 21 along the axial direction.

[0054] It should be noted that in this embodiment, there are two limiting posts 6, which are arranged symmetrically. When the rotating ring 22 rotates, the height of the two limiting posts 6 is always consistent, that is, they move synchronously from the trough section 51 to the crest section 52 or from the crest section 51 to the trough section 52, so as to avoid jamming.

[0055] In this embodiment, both sides of the upper end face of the lower sleeve 1 are provided with limiting grooves 12 that match the limiting post 6, for the insertion of the lower sleeve 1 and the filter sleeve 21, so as to limit the filter sleeve 21 while allowing the filter sleeve 21 to be suspended and supported in the middle of the inner cavity of the lower sleeve 1, so as to form a recovery chamber for recovering filtered water with the bottom wall of the inner cavity of the lower sleeve 1.

[0056] It should also be noted that when the filter sleeve 21 reciprocates relative to the lower sleeve 1 along the axial direction, the stirring assembly 31 is always located inside the filter sleeve 21 to improve the disturbance effect of the stirring assembly 31 on the dried packing.

[0057] In other embodiments, the top of the upper sleeve 3 is provided with a feed port 32 for putting in a dehydrating agent to mix with the descaling packing in the filter sleeve 21 for dehydration.

[0058] In a further embodiment, the upper sleeve 3 and the lower sleeve 1 are connected by threads to facilitate quick disassembly and replacement or repair of the components.

[0059] The upper sleeve 3 has an internal thread on its inner wall, and the lower sleeve 1 has an external thread on its outer wall, allowing the lower end face of the upper sleeve 3 to contact the rotating ring 22 for limiting its position. In other words, by specifically limiting the threaded connection between the upper sleeve 3 and the lower sleeve 1, the upper sleeve 3 is completely enclosed by the lower sleeve 1, ensuring that the upper sleeve 3 can contact the rotating ring 22 and preventing the rotating ring 22 from jumping during rotation.

[0060] Example 2

[0061] like Figure 4As shown, this embodiment adds a driving component 7 to the first embodiment, so as to control the rotation of the rotating ring 22 by using the driving component 7, thereby reducing labor intensity compared to the manual driving of the rotating ring 22 in the first embodiment.

[0062] Specifically, the chromatography medium solid-liquid separation device also includes a drive component 7.

[0063] The driving component 7 is detachably connected to the rotating ring 22 and is used to control the rotating ring 22 to rotate around its axis.

[0064] The driving component 7 includes a drive motor 72 with a bevel gear 71 fixedly mounted on its output end and a bevel gear ring 73.

[0065] The drive motor 72 is mounted on the annular protrusion 11, and the bevel gear ring 73 is fixedly mounted on the outer wall of the rotating ring 22 and meshes with the bevel gear 71. That is, the drive motor 72 provides a power source to transmit force through the meshing action of the bevel gear 71 and the bevel gear ring 73, thereby completing the rotation control of the rotating ring 22.

[0066] It should be noted that in this embodiment, when the rotating ring 22 moves along the axial direction, the bevel ring 73 and the bevel gear 71 can be separated. This allows all components to be disassembled for easy maintenance and replacement.

[0067] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A chromatographic medium solid-liquid separation device, characterized in that, It includes a lower sleeve (1), a rotary lifting filter assembly (2), and an upper sleeve (3) connected sequentially from bottom to top; The rotary lifting filter assembly (2) includes a filter sleeve (21) and a rotating ring (22); The filter sleeve (21) is inserted into the lower sleeve (1) along the axial direction and can slide relative to the lower sleeve (1) along the axial direction. A recovery chamber is formed between the bottom wall of the filter sleeve (21) and the bottom wall of the inner cavity of the lower sleeve (1). The rotating ring (22) is sleeved on the outside of the lower sleeve (1) and overlaps with the annular protrusion (11) provided on the outer wall of the lower sleeve (1), and the inner wall of the rotating ring (22) is movably connected to the filter sleeve (21). When the rotating ring (22) rotates, the filter sleeve (21) can reciprocate along the axial direction; The upper sleeve (3) is detachably connected to the lower sleeve (1), and its lower end face contacts the rotating ring (22), and it has a built-in stirring assembly (31) extending into the filter sleeve (21).

2. The chromatographic medium solid-liquid separation device as described in claim 1, characterized in that, The inner wall of the rotating ring (22) is provided with an annular groove (5), and the outer wall of the filter sleeve (21) is provided with a limiting post (6) that matches the annular groove (5). When the filter sleeve (21) is inserted into the lower sleeve (1), the limiting post (6) moves only along the axial direction of the filter sleeve (21); The annular groove (5) includes multiple staggered and smoothly connected trough segments (51) and crest segments (52); When the rotating ring (22) rotates, causing the limiting post (6) to move from the trough section (51) to the crest section (52), the filter sleeve (21) rises along the axial direction; When the rotating ring (22) rotates, causing the limiting post (6) to move from the crest section (52) to the trough section (51), the filter sleeve (21) descends along the axial direction.

3. The chromatographic medium solid-liquid separation device as described in claim 2, characterized in that, The upper end face of the lower sleeve (1) is provided with limiting grooves (12) that match the limiting post (6) on both sides.

4. The chromatographic medium solid-liquid separation device as described in claim 1, characterized in that, When the filter sleeve (21) moves reciprocally relative to the lower sleeve (1) along the axial direction, the stirring assembly (31) is always located inside the filter sleeve (21).

5. The chromatographic medium solid-liquid separation device as described in claim 1, characterized in that, It also includes the drive unit (7); The drive unit (7) is detachably connected to the rotating ring (22) and is used to control the rotating ring (22) to rotate around its axis.

6. The chromatographic medium solid-liquid separation apparatus as described in claim 5, characterized in that, The driving component (7) includes a drive motor (72) with a bevel gear (71) fixedly mounted on its output end and a bevel gear ring (73); The drive motor (72) is disposed on the annular protrusion (11); The bevel ring (73) is fixedly installed on the outer wall of the rotating ring (22) and meshes with the bevel gear (71).

7. The chromatographic medium solid-liquid separation apparatus as described in claim 6, characterized in that, When the rotating ring (22) moves along the axial direction, the bevel ring (73) can separate from the bevel gear (71).

8. The chromatographic medium solid-liquid separation apparatus as described in claim 1, characterized in that, The upper sleeve (3) is provided with a feed inlet (32) at its top.

9. The chromatographic medium solid-liquid separation apparatus as described in claim 1, characterized in that, The upper sleeve (3) and the lower sleeve (1) are connected by threads.

10. The chromatographic medium solid-liquid separation apparatus as described in claim 9, characterized in that, The inner wall of the upper sleeve (3) is provided with an internal thread, and the outer wall of the lower sleeve (1) is provided with an external thread, so that the lower end face of the upper sleeve (3) can contact the rotating ring (22) for limiting the rotation ring (22).

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