Exosome eye drop preparation particle size analysis device
By designing a particle size analysis device that includes agitation and cleaning components, the problems of low agitation efficiency, internal wall contamination, and light obstruction in the preparation of exosome eye drops were solved, achieving efficient and accurate particle size detection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- WUXI CHUYUANSAIER BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-07-15
- Publication Date
- 2026-06-12
AI Technical Summary
Existing exosome eye drop preparation devices suffer from problems such as low stirring efficiency, internal wall sedimentation and contamination, light obstruction during detection, and poor sealing, which affect the accuracy and efficiency of particle size detection.
A particle size analysis device was designed, comprising a liquid-containing cylinder, a laser emitter, a receiver, a particle size detection module, and a movable motor drive system, combined with an agitator and a cleaning component, to achieve rapid agitation, internal wall cleaning, and good sealing.
It achieves rapid and uniform mixing of the solution, leaves no residue on the inner wall, and ensures unobstructed detection light, thereby improving the accuracy and efficiency of particle size detection and reducing the risk of cross-contamination.
Smart Images
Figure CN224354271U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of exosome eye drops, specifically a particle size analysis device for the preparation of exosome eye drops. Background Technology
[0002] In the field of biopharmaceuticals, exosome eye drops have become a hot research area for the treatment of eye diseases due to their good biocompatibility and activity. The particle size distribution of exosomes is a key indicator for measuring their quality and activity, which directly affects the efficacy and safety of eye drops. Therefore, precise particle size analysis is required during the preparation process.
[0003] However, current particle size analysis devices used for the preparation of exosome eye drops have many problems in actual operation. First, during the standing or detection process, components of the exosome solution are prone to sedimentation, requiring rapid stirring of the liquid to ensure sample homogeneity. However, the existing stirring structure design is unreasonable, the stirring efficiency is low, and it is difficult to achieve rapid and uniform mixing of the liquid, which affects the accuracy of particle size detection.
[0004] Secondly, as the core component that holds the exosome eye drops, the inner wall of the sample container is prone to precipitation or residue due to the adhesion of the solution. These residues not only contaminate subsequent test samples but also change the actual concentration of the solution, leading to deviations in the test results. However, existing devices lack a convenient inner wall scraping and cleaning structure. The cleaning process often requires disassembling the sample container for manual cleaning, which is cumbersome and time-consuming, seriously affecting the testing efficiency.
[0005] Furthermore, existing stirring structures are typically fixed inside the sample container. During particle size analysis, the stirring components can obstruct or interfere with the detection light or probe, affecting the acquisition of detection signals and thus reducing the accuracy of particle size analysis. Additionally, the top of the sample container is often open, making effective sealing impossible. During stirring or transfer, solution can easily overflow, wasting exosome samples, contaminating the detection environment, and increasing the risk of cross-contamination. This severely impacts the accuracy and practicality of exosome eye drop analysis. Therefore, a particle size analysis device for exosome eye drop preparation needs to be designed to address these issues. Utility Model Content
[0006] The purpose of this invention is to provide a particle size analysis device for the preparation of exosome eye drops, so as to solve the problems mentioned in the background art.
[0007] To achieve the above objectives, this utility model provides the following technical solution: a particle size analysis device for preparing exosome eye drops, comprising an analysis chamber, a liquid container fixedly installed inside the analysis chamber near the top, a liquid supply pipe connected to one side of the liquid container, an outlet pipe fixedly connected to the bottom of the liquid container, a laser emitter bolted to one side of the analysis chamber, a laser receiver fixedly installed on the other side of the analysis chamber, a particle size detection module fixedly installed inside the other side of the analysis chamber, a drive component for driving a motor to move installed inside the analysis chamber near the top, a rotating shaft fixedly installed at the bottom of the motor via an output shaft, a cleaning component fitted on the outside of the rotating shaft, the cleaning component being used to scrape and clean the inner wall of the liquid container, and an agitator added on the outside of the rotating shaft near the bottom.
[0008] Preferably, the driving component includes a cylinder fixedly mounted to the top of the analysis chamber, and a fixing plate is fixedly mounted to the bottom of the cylinder via a push rod. The fixing plate is bolted to the motor.
[0009] Preferably, the cleaning component includes three fixed brackets fixedly connected to the outside of the rotating shaft, a sliding bracket slidably connected to one side of each fixed bracket, a scraper fixedly connected to one side of each sliding bracket, and a spring fixedly connected between the sliding bracket and the fixed bracket.
[0010] Preferably, the agitator includes three agitator plates fixedly connected to the bottom of the rotating shaft, and a scraper is fixedly connected to the bottom of each agitator plate.
[0011] Preferably, a cover plate is rotatably connected to the outside of the rotating shaft and near the top, a sealing ring is fitted on the outer edge of the cover plate, and a sealing ring is fixedly connected to the inside of the liquid container and near the top, the sealing ring being fitted with the sealing ring.
[0012] Preferably, a plurality of evenly arranged fixing rods are fixedly connected to the inner side of the fixing frame, and the fixing rods pass through one side of the sliding frame and are slidably connected to it.
[0013] Preferably, the agitator plate has a plurality of uniformly arranged liquid guiding holes on one side.
[0014] Compared with the prior art, the beneficial effects of this utility model are:
[0015] 1. The liquid container is installed and fixed to the analysis box by multiple bolts. Solenoid valves are embedded inside the liquid supply pipe and the liquid outlet pipe to control the supply and discharge of the solution. The laser generator emits laser light through the liquid container to the laser receiver. At this time, the particle size detection module detects and analyzes the laser particle size. The motor can drive the cleaning component and the stirring component to quickly stir and mix the solution to avoid solution sedimentation. The cleaning component can scrape and clean the inner wall of the liquid container. The drive component can drive the motor to move up and down to avoid the cleaning component and the stirring component being located inside the liquid container and affecting the accuracy and practicality of the detection module.
[0016] 2. The cylinder can drive the fixed plate to move up and down through the push rod. The motor on the top of the fixed plate is installed on the fixed plate with multiple bolts. The push rod can drive the rotating shaft at the bottom of the motor to move up and down through the fixed plate, so that the rotating shaft can enter or leave the liquid container and prevent the stirring and cleaning components from affecting the detection module. Attached Figure Description
[0017] Figure 1 This is a schematic diagram of the overall structure of the present invention;
[0018] Figure 2 This is a left-side sectional perspective view of the overall structure of this utility model;
[0019] Figure 3 This is a front sectional perspective view of the overall structure of this utility model;
[0020] Figure 4 The overall structure of this utility model Figure 2 Enlarged view of point A in the middle;
[0021] Figure 5 The overall structure of this utility model Figure 2 Enlarged view at point B in the middle;
[0022] Figure 6 The overall structure of this utility model Figure 2 Enlarged view of point C in the middle.
[0023] In the diagram: 1. Analysis chamber; 2. Liquid container; 3. Liquid supply pipe; 4. Liquid outlet pipe; 5. Laser emitter; 6. Laser receiver; 7. Particle size detection module; 8. Motor; 9. Rotating shaft; 10. Cylinder; 11. Push rod; 12. Fixing plate; 13. Fixing frame; 14. Sliding frame; 15. Scraper; 16. Spring; 17. Stirring plate; 18. Scraper; 19. Cover plate; 20. Sealing ring; 21. Sealing ring; 22. Fixing rod; 23. Liquid guide hole. Detailed Implementation
[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0025] Example 1
[0026] Please refer to Figure 1-6 As shown, this utility model provides a particle size analysis device for preparing exosome eye drops, including an analysis chamber 1. A liquid container 2 is fixedly installed inside the analysis chamber 1 near the top. A liquid supply pipe 3 is connected to one side of the liquid container 2, and a liquid outlet pipe 4 is fixedly connected to the bottom of the liquid container 2. A laser emitter 5 is installed on one side of the analysis chamber 1 by bolts, and a laser receiver 6 is fixedly installed on the other side of the analysis chamber 1. A particle size detection module 7 is fixedly installed inside the analysis chamber 1 on the other side. A drive component for moving a motor 8 is installed inside the analysis chamber 1 near the top. A rotating shaft 9 is fixedly installed at the bottom of the motor 8 through an output shaft. A cleaning component is fitted on the outside of the rotating shaft 9. The cleaning component is used to scrape and clean the inner wall of the liquid container 2. An agitator is added on the outside of the rotating shaft 9 near the bottom.
[0027] It should be added that the liquid container 2 is installed and fixed to the analysis box 1 by multiple bolts. Solenoid valves are embedded inside the liquid supply pipe 3 and the liquid outlet pipe 4 to control the supply and discharge of the solution. The laser generator emits laser light through the liquid container 2 to the laser receiver 6. At this time, the particle size detection module 7 detects and analyzes the laser particle size. The motor 8 can drive the cleaning component and the stirring component to quickly stir and mix the solution to avoid solution sedimentation. The cleaning component can scrape and clean the inner wall of the liquid container. The drive component can drive the motor 8 to move up and down to avoid the cleaning component and the stirring component being located inside the liquid container 2 and affecting the accuracy and practicality of the detection module.
[0028] Specifically, the driving component includes a cylinder 10 fixedly installed on the top of the analyzer 1. A fixing plate 12 is fixedly installed on the bottom of the cylinder 10 via a push rod 11. The fixing plate 12 is bolted to the motor 8. A cover plate 19 is rotatably connected to the outside of the rotating shaft 9 near the top. A sealing ring 20 is fitted on the outer edge of the cover plate 19. A sealing ring 21 is fixedly connected to the inside of the liquid container 2 near the top. The sealing ring 20 and the sealing ring 21 are fitted together.
[0029] The cylinder 10 can drive the fixed plate 12 to move up and down through the push rod 11. The motor 8 on the top of the fixed plate 12 is installed on the fixed plate 12 by multiple bolts. The push rod 11 can drive the rotating shaft 9 at the bottom of the motor 8 to move up and down through the fixed plate 12, so that the rotating shaft 9 can enter or leave the liquid container 2, preventing the stirring and cleaning components from affecting the detection module. The rotating shaft 9 drives the cover plate 19 to fit against the top of the liquid container 2. The sealing ring 21 and the sealing ring 20 are tightly fitted to prevent the solution from overflowing or splashing out, causing waste or pollution.
[0030] More specifically, the cleaning component includes three fixed brackets 13 fixedly connected to the outside of the rotating shaft 9. A sliding bracket 14 is slidably connected to one side of the fixed bracket 13. A scraper 15 is fixedly connected to one side of the sliding bracket 14. A spring 16 is fixedly connected between the sliding bracket 14 and the fixed bracket 13. A plurality of evenly arranged fixed rods 22 are fixedly connected to the inside of the fixed bracket 13. The fixed rods 22 pass through one side of the sliding bracket 14 and are slidably connected to it.
[0031] In addition, the fixed rod 22 can guide the sliding frame 14, the spring 16 on the outside of the fixed rod 22 can squeeze and push the sliding frame 14, the fixed frame 13 can drive the sliding frame 14 to stir and mix the solution, the sliding frame 14 rotates under centrifugal force and slides with the fixed frame 13, and then the scraper 15 on the side of the sliding frame 14 scrapes and cleans the inner wall of the liquid container 2.
[0032] Furthermore, the agitator includes three agitator plates 17 fixedly connected to the bottom of the rotating shaft 9. A scraper 18 is fixedly connected to the bottom of the agitator plate 17, and a plurality of uniformly arranged liquid guiding holes 23 are opened on one side of the agitator plate 17.
[0033] The rotating shaft 9 drives three stirring plates 17 to stir and mix the lower part of the solution. Multiple liquid guiding holes 23 on one side of the stirring plate 17 facilitate the solution to pass through the stirring plate 17, accelerate the rotation speed of the aqueous solution, and prevent the solution from settling. The scraper 18 at the bottom of the stirring plate 17 scrapes the bottom of the liquid container 2.
[0034] Working principle: First, start the motor 8 to drive the rotating shaft 9 to rotate rapidly. At this time, the rotating shaft 9 drives the three stirring plates 17 to stir and mix the lower part of the solution. At the same time, multiple liquid guiding holes 23 facilitate the solution to pass through the stirring plates 17. Then, the fixed frame 13 and the sliding frame 14 stir and mix the solution. After stirring, the cylinder 10 is used to drive the motor 8 on the top of the fixed plate 12 to move upward through the push rod 11. At this time, the cover plate 19 is separated from the liquid container 2. Then, the laser generator emits laser light through the liquid container 2 to reach the laser receiver 6. At this time, the particle size detection module 7 detects and analyzes the laser particle size.
[0035] The contents not described in detail in this specification are existing technologies known to those skilled in the art.
[0036] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
Claims
1. A particle size analysis device for preparing exosome eye drops, comprising an analysis chamber (1), characterized in that: A liquid container (2) is fixedly installed inside the analysis box (1) and near the top. A liquid supply pipe (3) is connected to one side of the liquid container (2). A liquid outlet pipe (4) is fixedly connected to the bottom of the liquid container (2). A laser emitter (5) is installed on one side of the analysis box (1) by bolts. A laser receiver (6) is fixedly installed on the other side of the analysis box (1). A particle size detection module (7) is fixedly installed inside the analysis box (1) on the other side. A drive component for moving a motor (8) is installed inside the analysis box (1) and near the top. A rotating shaft (9) is fixedly installed at the bottom of the motor (8) through an output shaft. A cleaning component is fitted on the outside of the rotating shaft (9). The cleaning component is used to scrape and clean the inner wall of the liquid container (2). An agitator is added on the outside of the rotating shaft (9) and near the bottom.
2. The particle size analysis device for preparing exosome eye drops according to claim 1, characterized in that: The driving component includes a cylinder (10) fixedly mounted to the top of the analysis box (1), and a fixing plate (12) fixedly mounted to the bottom of the cylinder (10) by a push rod (11). The fixing plate (12) is bolted to the motor (8).
3. The particle size analysis device for preparing exosome eye drops according to claim 2, characterized in that: The cleaning component includes three fixed brackets (13) fixedly connected to the outside of the rotating shaft (9). A sliding bracket (14) is slidably connected to one side of the fixed bracket (13). A scraper (15) is fixedly connected to one side of the sliding bracket (14). A spring (16) is fixedly connected between the sliding bracket (14) and the fixed bracket (13).
4. The particle size analysis device for preparing exosome eye drops according to claim 3, characterized in that: The agitator includes three agitator plates (17) fixedly connected to the bottom of the rotating shaft (9), and a scraper (18) is fixedly connected to the bottom of the agitator plates (17).
5. The particle size analysis device for preparing exosome eye drops according to claim 4, characterized in that: A cover plate (19) is rotatably connected to the outside of the rotating shaft (9) and near the top. A sealing ring (20) is fitted on the outer edge of the cover plate (19). A sealing ring (21) is fixedly connected to the inside of the liquid container (2) and near the top. The sealing ring (20) and the sealing ring (21) are fitted together.
6. The particle size analysis device for preparing exosome eye drops according to claim 4, characterized in that: The inner side of the fixed frame (13) is fixedly connected with a plurality of uniformly arranged fixed rods (22), and the fixed rods (22) pass through one side of the sliding frame (14) and are slidably connected to it.
7. The particle size analysis device for preparing exosome eye drops according to claim 5, characterized in that: The stirring plate (17) has a plurality of uniformly arranged liquid guiding holes (23) on one side.