A heparin coated dialyzer

Abstract

The utility model discloses a heparin coating dialyzer relates to medical instrument technical field, including dialyzer main casing and dialysis subassembly, and dialyzer main casing is integrated structure, dialysis subassembly sets up in the inboard of dialysis subassembly, and dialysis subassembly includes dialysis outer membrane, compact interstice, fixed connection ring, heparin protection coating and macropore dialysis inner membrane, dialysis outer membrane sets up in the inboard of dialyzer main casing. The heparin coating dialyzer, through dialysis subassembly makes the device can improve the efficiency of dialysis treatment significantly, and heparin is attached in the dialysis membrane surface of dialyzer, effectively improves the biocompatibility and antithrombus performance of dialysis membrane, makes heparin's anticoagulation effect be limited to dialyzer surface only, and the physiological environment of whole blood is not changed, is helpful to reduce heparin's side effect in the body, through sealing assembly makes the device can improve the sealing of device whole, prevents the leakage, improves the security when using.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a heparin-coated dialyzer. Background Technology

[0002] Hemodialysis, a common extracorporeal circulation treatment for acute or chronic renal failure, works by removing toxic and harmful substances from the blood through a dialyzer membrane to treat the disease and maintain life. During dialysis, coagulation is the most common adverse reaction. Blood clots can form in the dialyzer or other dialysis equipment, obstructing blood flow, affecting dialysis effectiveness, and even endangering the patient's life. Heparin is the most commonly used anti-coagulant in hemodialysis, keeping the blood flowing within the dialyzer and tubing. Currently, to ensure the smooth implementation of hemodialysis treatment, heparin-coated dialyzers are typically used.

[0003] Commercially available heparin-coated dialyzers allow heparin to act directly into the bloodstream. Heparin can enhance systemic anticoagulation by inhibiting thrombin and platelet function, thereby increasing the risk of bleeding. To address this, we propose a heparin-coated dialyzer. Utility Model Content

[0004] The purpose of this invention is to provide a heparin-coated dialyzer to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a heparin-coated dialyzer, comprising a dialyzer main housing and a dialysis assembly. The dialyzer main housing is an integral structure. The dialysis assembly is disposed inside the dialysis assembly and includes an outer dialysis membrane, dense pores, fixing rings, a heparin protective coating, and a large-pore inner dialysis membrane. The outer dialysis membrane is disposed inside the dialyzer main housing, and its surface has dense pores. Fixing rings are disposed on both sides of the outer dialysis membrane, and the outer surface of the fixing rings is tightly connected to both ends of the inner surface of the dialyzer main housing. The outer dialysis membrane is an integral structure, and its surface is coated with a heparin protective coating. A large-pore inner dialysis membrane is disposed inside the outer dialysis membrane.

[0006] Furthermore, a dialysate outlet pipe is installed on the lower left side of the main body of the dialyzer, and a dialysate inlet pipe is provided on the lower right side of the main body of the dialyzer.

[0007] Furthermore, the dialyzer main housing, dialysate outlet pipe, and dialysate inlet pipe are a tightly connected integrated structure, and the dialysate outlet pipe and dialysate inlet pipe are symmetrically arranged on the lower side of the dialyzer main housing.

[0008] Furthermore, a threaded connecting ring is installed on the lower side of the dialysate outlet tube and the dialysate inlet tube, and a small cap is threaded onto the outer surface of the threaded connecting ring.

[0009] Furthermore, the dialyzer main housing surface is provided with a sealing assembly for sealing, and the sealing assembly includes a support ring, sealing adhesive, a right blood cap and a blood outlet, with the support ring disposed at both ends of the outer surface of the dialyzer main housing.

[0010] Furthermore, sealing adhesive is provided at both ends of the outer surface of the dialyzer main housing, and a right blood cap is connected to the right end of the dialyzer main housing through the sealing adhesive, and a blood outlet is provided on the surface of the right blood cap.

[0011] Furthermore, the sealing assembly also includes a left blood cap, a blood inlet, and a sealing plug, and the left blood cap is connected to the left end of the dialyzer main housing via sealing adhesive.

[0012] Furthermore, the left blood cap surface is provided with a blood inlet, and both the blood inlet and the blood outlet are provided with sealing plugs on their outer sides.

[0013] This invention provides a heparin-coated dialyzer, which has the following beneficial effects:

[0014] 1. This utility model, through the design of a dialysis assembly, includes an outer dialysis membrane, dense pores, a fixing connecting ring, a heparin protective coating, and a large-pore inner dialysis membrane. During use, heparin or low molecular weight heparin injection water enters the outer dialysis membrane of the dialyzer main housing through the dialysate inlet tube. Compressed air then blows across the entire dialyzer, allowing heparin or low molecular weight heparin to permeate from the outside of the membrane into the dense pores on its surface through osmosis. Low-temperature negative pressure drying further prevents molecular degradation, ultimately achieving physical fixation of the heparin or low molecular weight heparin and forming a heparin protective coating on the outer dialysis membrane surface. During dialysis, the dense pores on the outer dialysis membrane surface allow selective permeation of small molecule toxins while blocking blood cells and large molecule proteins. The large-pore dialysis inner membrane, through its highly porous finger-like channel structure, significantly enhances the convective clearance efficiency of medium-molecular-weight toxins, while also providing mechanical support to the outer dialysis membrane and reducing transmembrane pressure. The heparin protective coating effectively inhibits platelet aggregation and fibrin formation, reducing the risk of thrombosis. Furthermore, it allows for a reduction in the amount of heparin used during dialysis treatment based on actual needs, improving the safety and patient comfort of the dialysis process. This significantly improves the efficiency of dialysis treatment. The heparin adheres to the dialyzer membrane surface, effectively enhancing the membrane's biocompatibility and antithrombotic properties, ensuring that the anticoagulant effect of heparin is limited to the dialyzer surface without altering the overall physiological environment of the blood, thus helping to reduce the side effects of heparin in the body.

[0015] 2. This utility model incorporates a sealing assembly, which includes a support ring, sealing adhesive, a right blood cap, and a blood outlet. The assembly also includes a left blood cap, a blood inlet, and a sealing plug. During use, the sealing adhesive, made of polyurethane, forms an airtight seal at the junction of the fixing ring and the dialyzer's main housing, preventing cross-leakage between blood and dialysate during high-pressure circulation. This ensures that solute exchange occurs solely through the fiber membrane. The sealing plug provides a stable seal to the blood inlet and outlet, preventing external microorganisms from entering and reducing infection. Therefore, this device improves overall sealing, prevents leakage, and enhances safety during use. Attached Figure Description

[0016] Figure 1 This is a three-dimensional cross-sectional view of a heparin-coated dialyzer according to the present invention;

[0017] Figure 2 This is a three-dimensional structural diagram of a heparin-coated dialyzer according to the present invention;

[0018] Figure 3 This is a three-dimensional structural diagram of the dialysis component of a heparin-coated dialyzer according to the present invention.

[0019] In the diagram: 1. Dialyzer main housing; 2. Dialysis assembly; 201. Dialysis outer membrane; 202. Dense pores; 203. Fixing ring; 204. Heparin protective coating; 205. Large-pore dialysis inner membrane; 3. Dialysis fluid outlet tube; 4. Dialysis fluid inlet tube; 5. Threaded connecting ring; 6. Small cap; 7. Sealing assembly; 701. Support ring; 702. Sealing adhesive; 703. Right blood cap; 704. Blood outlet; 705. Left blood cap; 706. Blood inlet; 707. Sealing plug. Detailed Implementation

[0020] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of this utility model.

[0021] like Figures 1 to 3As shown, a heparin-coated dialyzer includes a main dialyzer housing 1 and a dialyzer assembly 2. The main dialyzer housing 1 is an integral structure. The dialyzer assembly 2 is disposed inside the dialyzer assembly 2, and the dialyzer assembly 2 includes an outer dialyzer membrane 201, dense pores 202, a fixing ring 203, a heparin protective coating 204, and a large-pore inner dialyzer membrane 205. The outer dialyzer membrane 201 is disposed inside the main dialyzer housing 1, and dense pores 202 are formed on the surface of the outer dialyzer membrane 201. Fixing rings 203 are provided on both sides of the outer dialyzer membrane 201, and the outer surface of the fixing rings 203 is tightly connected to both ends of the inner surface of the main dialyzer housing 1. The outer dialyzer membrane 201 is an integral structure, and the surface of the outer dialyzer membrane 201 is provided with a heparin protective coating 204. A large-pore inner dialyzer membrane 205 is provided inside the outer dialyzer membrane 201.

[0022] The specific operation is as follows: During use, heparin or low molecular weight heparin injection water enters the outer side of the dialysis membrane 201 of the dialyzer main housing 1 through the dialysate inlet tube 4. Compressed air then blows across the entire dialyzer, causing heparin or low molecular weight heparin to permeate from the outside of the dialysis membrane 201 into the dense pores 202 on its surface through osmosis. Low-temperature negative pressure drying is then performed to prevent molecular degradation, ultimately completing the physical fixation of heparin or low molecular weight heparin and forming a heparin protective coating 204 on the surface of the dialysis membrane 201. During dialysis, the surface of the dialysis membrane 201... The dense pores 202 enable selective permeation of small molecule toxins while blocking the loss of blood cells and large molecule proteins, and act as a biological interface to reduce platelet adhesion. The large-pore dialysis inner membrane 205, through its highly porous finger-like channel structure, significantly improves the convective clearance efficiency of medium molecule toxins, while providing mechanical support for the dialysis outer membrane 201 and reducing transmembrane pressure. The heparin protective coating 204 effectively inhibits platelet aggregation and fibrin formation, reducing the risk of thrombosis, and can reduce the amount of heparin used during dialysis treatment according to actual needs, improving the safety of the dialysis process and patient comfort.

[0023] Please refer to Figures 1 to 2A dialysate outlet tube 3 is installed on the lower left side of the dialyzer main housing 1, and a dialysate inlet tube 4 is provided on the lower right side of the dialyzer main housing 1. The dialyzer main housing 1, the dialysate outlet tube 3, and the dialysate inlet tube 4 are a tightly connected integrated structure. The dialysate outlet tube 3 and the dialysate inlet tube 4 are symmetrically arranged on the lower side of the dialyzer main housing 1. A threaded connecting ring 5 is installed on the lower side of the dialysate outlet tube 3 and the dialysate inlet tube 4, and a small cap 6 is threadedly connected to the outer surface of the threaded connecting ring 5. A sealing assembly 7 for sealing is provided on the surface of the dialyzer main housing 1, and the sealing assembly 7 includes a support ring 701, sealing adhesive 702, a right blood cap 703, and a blood... The main body of the dialyzer has a liquid outlet 704 and a support ring 701, which are located at both ends of the outer surface of the dialyzer main housing 1. Sealing adhesive 702 is provided at both ends of the outer surface of the dialyzer main housing 1. A right blood cap 703 is connected to the right end of the dialyzer main housing 1 through the sealing adhesive 702. A blood outlet 704 is provided on the surface of the right blood cap 703. The sealing assembly 7 also includes a left blood cap 705, a blood inlet 706 and a sealing plug 707. A left blood cap 705 is connected to the left end of the dialyzer main housing 1 through the sealing adhesive 702. A blood inlet 706 is provided on the surface of the left blood cap 705. A sealing plug 707 is provided on the outside of both the blood inlet 706 and the blood outlet 704.

[0024] The specific operation is as follows: During use, the dialysate outlet tube 3 and dialysate inlet tube 4 are sealed by connecting the small cap 6 to the threaded connection ring 5. The sealing adhesive 702 is made of polyurethane. The sealing adhesive 702 forms an airtight seal at the connection between the fixed connection ring 203 and the dialyzer main housing 1 to prevent cross-leakage of blood and dialysate during high-pressure circulation, ensuring that solute exchange only occurs through the fiber membrane. The sealing plug 707 provides a stable seal for the blood inlet 706 and the blood outlet 704 to prevent external microorganisms from entering the interior and reduce infection.

[0025] In summary, as Figures 1 to 3As shown, in use, heparin-coated dialyzer first introduces heparin or low molecular weight heparin injection water into the outer dialysis membrane 201 of the dialyzer main housing 1 via the dialysate inlet tube 4. Compressed air then blows through the entire dialyzer, allowing heparin or low molecular weight heparin to permeate from the outer membrane 201 into the dense pores 202 on its surface through osmosis. Low-temperature negative pressure drying further prevents molecular degradation, ultimately achieving physical fixation of the heparin or low molecular weight heparin and forming a heparin protective coating 204 on the surface of the outer membrane 201. During dialysis, the dense pores 202 on the surface of the outer membrane 201 allow selective permeation of small molecule toxins while preventing the loss of blood cells and large molecule proteins. It also acts as a biological interface to reduce platelet adhesion. The large-pore inner dialysis membrane 205, through its highly porous finger-like channel structure, significantly improves the permeability of medium molecular weight heparin. The heparin protective coating 204 effectively inhibits platelet aggregation and fibrin formation, reducing the risk of thrombosis. It also allows for a reduction in the amount of heparin used during dialysis, improving safety and patient comfort. The small cap 6 and the threaded connection of the threaded connecting ring 5 seal the dialysate outlet tube 3 and dialysate inlet tube 4. The sealing adhesive 702, made of polyurethane, forms an airtight seal at the junction of the fixing connecting ring 203 and the dialyzer main housing 1, preventing cross-leakage of blood and dialysate during high-pressure circulation and ensuring solute exchange occurs only through the fiber membrane. The sealing plug 707 provides a stable seal for the blood inlet 706 and blood outlet 704, preventing external microorganisms from entering and reducing infection.

[0026] The embodiments of this utility model are given for illustrative and descriptive purposes only, and are not intended to be exhaustive or to limit the utility model to the forms disclosed. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described in order to better illustrate the principles and practical applications of this utility model, and to enable those skilled in the art to understand this utility model and design various embodiments with various modifications suitable for a particular purpose.

Claims

1. A heparin-coated dialyzer, comprising a dialyzer main housing (1) and a dialysing assembly (2), characterized in that: The dialyzer main housing (1) is an integrated structure. The dialysis assembly (2) is disposed inside the dialysis assembly (2). The dialysis assembly (2) includes an outer dialysis membrane (201), a dense pore structure (202), a fixing connecting ring (203), a heparin protective coating (204), and a large-pore inner dialysis membrane (205). The outer dialysis membrane (201) is disposed inside the dialyzer main housing (1), and the surface of the outer dialysis membrane (201) has openings. The outer dialysis membrane (201) has dense pores (202), and fixed connecting rings (203) are provided on both sides of the outer dialysis membrane (201). The outer surface of the fixed connecting rings (203) is tightly connected to the two ends of the inner surface of the dialyzer main housing (1). The outer dialysis membrane (201) is an integrated structure, and a heparin protective coating (204) is provided on the surface of the outer dialysis membrane (201). A large-pore inner dialysis membrane (205) is provided on the inner side of the outer dialysis membrane (201).

2. The heparin-coated dialyzer according to claim 1, characterized in that, The dialyzer main housing (1) is equipped with a dialysate outlet pipe (3) on the lower left side, and a dialysate inlet pipe (4) is provided on the lower right side of the dialyzer main housing (1).

3. The heparin-coated dialyzer according to claim 1, characterized in that, The dialyzer main housing (1), dialysate outlet pipe (3), and dialysate inlet pipe (4) are a tightly connected integrated structure, and the dialysate outlet pipe (3) and dialysate inlet pipe (4) are symmetrically arranged on the lower side of the dialyzer main housing (1).

4. A heparin-coated dialyzer according to claim 3, characterized in that, A threaded connecting ring (5) is installed on the lower side of the dialysate outlet tube (3) and the dialysate inlet tube (4), and a small cap (6) is threadedly connected to the outer surface of the threaded connecting ring (5).

5. A heparin-coated dialyzer according to claim 1, characterized in that, The dialyzer main housing (1) is provided with a sealing assembly (7) for sealing, and the sealing assembly (7) includes a support ring (701), sealing adhesive (702), right blood cap (703) and blood outlet (704). The support ring (701) is provided at both ends of the outer surface of the dialyzer main housing (1).

6. A heparin-coated dialyzer according to claim 5, characterized in that, The dialyzer main housing (1) has sealing adhesive (702) at both ends on its outer surface, and the right end of the dialyzer main housing (1) is connected to a right blood cap (703) through the sealing adhesive (702). The right blood cap (703) has a blood outlet (704) on its surface.

7. A heparin-coated dialyzer according to claim 5, characterized in that, The sealing assembly (7) also includes a left blood cap (705), a blood inlet (706) and a sealing plug (707), and the left blood cap (705) is connected to the left end of the dialyzer main housing (1) by a sealing adhesive (702).

8. A heparin-coated dialyzer according to claim 7, characterized in that, The left blood cap (705) is provided with a blood inlet (706) on its surface, and both the blood inlet (706) and the blood outlet (704) are provided with sealing plugs (707) on their outer sides.

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