Microfluidic chip and tissue staining device comprising the same

By using a microfluidic chip design with an open reagent compartment and a closed pressure pump system, the problems of complex reagent delivery and high cost in existing technologies are solved, enabling rapid and low-cost multiplex immunofluorescence staining and improving staining efficiency and consistency.

CN224365841UActive Publication Date: 2026-06-16NANJING TAILI RUI INFORMATION TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
NANJING TAILI RUI INFORMATION TECH CO LTD
Filing Date
2025-03-27
Publication Date
2026-06-16

AI Technical Summary

⚠Technical Problem

Existing microfluidic tissue staining methods suffer from problems such as complex reagent delivery, cumbersome operation, high cost, low throughput, and high cost of microfluidic chips. In particular, in multiplex immunofluorescence staining, there are many types of reagents and the complexity and cost of rotary valve systems are increased.

⚗Method used

It adopts an open reagent compartment design and a closed pressure pump system, which controls the entry and exit of reagents into and out of the chip through the pressure pump, eliminating complex pipeline systems, increasing the variety of reagents and staining throughput, and using an automatic pipetting system and pressure pump for rapid and precise control of reagents.

🎯Benefits of technology

Significantly shorten staining time, reduce system complexity and cost, improve reagent utilization, ensure staining consistency and flexibility, and achieve efficient multiplex immunofluorescence staining.

✦ Generated by Eureka AI based on patent content.

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    Figure CN224365841U_ABST
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Abstract

The utility model discloses a micro -fluidic chip and including its tissue dyeing device. The utility model discloses a micro -fluidic chip includes upper glass sheet, and upper glass sheet is equipped with entrance hole and export hole, double -sided adhesive layer, and double -sided adhesive layer presents corresponding micro -fluidic chip's flow channel, dyeing cavity and flow channel with the removal part double -sided adhesive layer through cutting, wherein flow channel is linked with entrance hole, and export hole is linked with flow channel, and lower glass sheet, and the tissue to be dyed is arranged on lower glass sheet, wherein upper glass sheet and lower glass sheet are adhered into a whole through double -sided adhesive layer. The reagent bin is equipped with at the entrance of micro -fluidic chip, and the reagent bin is open -mouthed design, and the export of micro -fluidic chip is connected with pressure pump. Through pressure pump, the reagent in reagent bin is pumped to the dyeing cavity of micro -fluidic chip and carries out dyeing, and it is discharged after dyeing. The utility model reduces the complexity and cost of system, and reduces the waste of reagent simultaneously.
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