A polypeptide biosynthesis reactor vessel that is easy to clean

Abstract

The utility model discloses a polypeptide biosynthesis reation kettle convenient to clean relates to polypeptide biotechnology field, including base, reation kettle body, support leg, valve, reation kettle cover, locking bolt, nut, cover, first motor, lead screw, bearing seat, lifting piece, slot, lifting support and cleaning stirring assembly etc.

Description

Technical Field

[0001] This utility model relates to the field of polypeptide biotechnology, and in particular to a polypeptide biosynthesis reactor that is easy to clean. Background Technology

[0002] In the field of peptide biosynthesis, the reactor is a core piece of equipment, and its cleaning effectiveness is crucial to product quality and production efficiency. Traditional peptide biosynthesis reactors often retain reactants, catalysts, and other impurities after use. Current reactor cleaning methods primarily rely on manual operation, requiring operators to manually disassemble and wipe each component. This method is not only time-consuming and labor-intensive, but also inefficient. Furthermore, it struggles to thoroughly clean complex internal structures (such as stirring shafts and inner wall corners), easily leading to cleaning agent residue or microbial growth, affecting the accuracy of subsequent reactions and product purity. Simultaneously, improper operation during manual cleaning can scratch the reactor's inner wall or damage seals, reducing equipment lifespan. In addition, the fixed structure of traditional reactor cleaning devices prevents flexible adjustment of cleaning intensity and scope based on the degree of contamination in different areas of the reactor, resulting in inconsistent cleaning effectiveness. With the increasing demands for refined and large-scale peptide synthesis processes, there is an urgent need for a reactor cleaning system that can achieve efficient, convenient, and comprehensive cleaning to address the problems of low efficiency, incomplete cleaning, and equipment damage associated with traditional cleaning methods, ensuring the stability of the peptide synthesis process and product quality. Utility Model Content

[0003] The purpose of this invention is to provide a polypeptide biosynthesis reactor that is easy to clean in order to solve the above problems.

[0004] To address the aforementioned problems, this utility model provides a technical solution: an easy-to-clean polypeptide biosynthesis reactor, comprising a base, reactor body, support legs, valves, reactor cover, locking bolts, nuts, a casing, a first motor, a lead screw, a bearing seat, a lifting block, a slot, a lifting support, and a cleaning and stirring assembly; several support legs are fixedly connected to the lower surface of the reactor body, and the support legs are fixedly connected to the left side of the upper surface of the base; a valve is connected to the bottom end of the reactor body; a reactor cover is provided on the reactor body, and the reactor body and the reactor cover are connected by a... The base is secured with locking bolts and nuts; a cover is fixedly connected to the right side of the upper surface of the base; a first motor is fixedly connected to the bottom surface of the cover chamber; a bearing seat is fixedly connected to the top surface of the cover chamber; slots are provided on both sides of the cover; a lead screw is fixedly connected to the output end of the first motor; the other end of the lead screw is movably connected to the bearing seat; a lifting block is threaded onto the lead screw; the two ends of the lifting block are slidably connected to the slots; lifting brackets are fixedly connected to both ends of the lifting block; a cleaning and stirring assembly is connected to the lifting brackets.

[0005] Preferably, the cleaning and stirring assembly comprises a second motor, a rotating arm, a third motor, a rotating shaft, a stirring rod, a column, a rotating rod, a bearing, a first gear, a fourth motor, a second gear, a connecting rod, a first cleaning sponge, an inner tube, a second cleaning sponge, and a spring. The second motor is fixedly connected to the top of the lifting bracket. A rotating arm is fixedly connected to the output end of the second motor. A third motor is fixedly connected to the left side of the lower surface of the rotating arm, and a rotating shaft is fixedly connected to the output end of the third motor. Several stirring rods are fixedly connected to the rotating shaft. A column is fixedly connected to the right side of the lower surface of the rotating arm, and a rotating rod is movably connected to the end of the column via a bearing. A first gear is fixedly connected to the top of the rotating rod. A fourth motor is fixedly connected to the side of the end of the column, and a second gear is fixedly connected to the output end of the fourth motor. The second gear meshes with the first gear. A first cleaning sponge is fixedly connected to both sides of the rotating rod via a connecting rod. An inner tube is connected to the end of the rotating rod, and a spring is fixedly connected between the inner tube and the rotating rod. A second cleaning sponge is fixedly connected to the end of the inner tube.

[0006] Preferably, the first and second cleaning sponges are made of corrosion-resistant fiber material, and the surface is provided with dense embossed texture to improve cleaning efficiency.

[0007] Preferably, the contact surface between the reactor lid and the reactor body is provided with an annular sealing ring to improve sealing performance.

[0008] Preferably, the base is provided with an anti-slip rubber pad to enhance the stability of the device.

[0009] Preferably, both the first gear and the second gear are coated with grease.

[0010] The beneficial effects of this utility model are as follows: (1) High cleaning efficiency and thorough effect: The first motor drives the screw to move the lifting bracket up and down, so that the cleaning and stirring assembly can cover the entire height range of the reactor body, achieving longitudinal cleaning without dead corners; the second motor drives the rotating arm to rotate the cleaning assembly, and in conjunction with the third motor drives the stirring rod, the stirring cleaning and inner wall wiping can be completed at the same time, significantly improving the cleaning efficiency. The first cleaning sponge is fixed to both sides of the rotating rod by the connecting rod, and rotates at high speed with the rotating rod (driven by the fourth motor through gear transmission), closely adhering to the inner wall of the reactor for ring wiping, effectively removing residual impurities from the inner wall. The second cleaning sponge is connected to the end of the inner tube by the spring, which can adapt to the curvature of the bottom of the reactor, and closely adhere to the bottom corner under the action of the spring force, solving the problem of dead corners that are difficult to reach by traditional manual cleaning. The cleaning sponge is made of corrosion-resistant fiber material, and the surface dense convex design increases the friction coefficient, enhances the peeling ability of stubborn stains, and avoids scratching the inner wall of the reactor.

[0011] (2) Convenient operation and equipment protection: No manual disassembly of the reactor lid or internal components is required. The entire cleaning process is completed by an automated cleaning assembly, reducing the intensity of manual operation and the risk of wear on seals caused by frequent disassembly. The spring-connected inner tube structure can automatically adjust the pressure of the second cleaning sponge according to the cleaning resistance, avoiding excessive squeezing and damage to the bottom of the reactor; the gear transmission system is coated with grease to reduce mechanical wear and extend the service life of the equipment; the annular sealing ring improves the sealing performance between the reactor lid and the reactor body, prevents liquid leakage during the cleaning process, and ensures operational safety.

[0012] (3) Stable structure and strong adaptability: The anti-slip rubber pad at the bottom of the base enhances the equipment's vibration resistance and prevents displacement during cleaning; the support legs are fixedly connected to the base, and together with the rigid structure of the cover, ensure the stability of the lifting support during movement. The cleaning and stirring assembly can not only be used for cleaning, but also as a stirring device during the reaction process (driven by a third motor to stir the stirring rod), realizing the integration of "reaction-cleaning" functions, reducing equipment idle rate and lowering production costs.

[0013] (4) Production efficiency and quality assurance: Automated cleaning processes can significantly shorten the time for a single cleaning cycle, which is especially suitable for the rapid turnaround requirements of multiple batches of reactions in large-scale production. Thoroughly cleaning the inner walls and bottom of the reactor and the bottom of the reactor reduces the residue of cleaning agents and microorganisms, ensuring the accuracy of subsequent peptide synthesis reactions and the purity of the products, and improving the stability of production quality. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model.

[0015] Figure 2 This is a schematic diagram of the structure between the reactor body and the reactor cover of this utility model.

[0016] Figure 3 This utility model Figure 1 A partially enlarged structural diagram.

[0017] 1-Base; 2-Reaction vessel body; 3-Support leg; 4-Valve; 5-Reaction vessel cover; 6-Locking bolt; 7-Nut; 8-Cover; 9-First motor; 10-Lead screw; 11-Bearing seat; 12-Lifting block; 13-Slotted; 14-Lifting bracket; 15-Second motor; 16-Rotating arm; 17-Third motor; 18-Rotating shaft; 19-Stirring rod; 20-Column; 21-Rotating rod; 22-Bearing; 23-First gear; 24-Fourth motor; 25-Second gear; 26-Connecting rod; 27-First cleaning sponge; 28-Inner tube; 29-Second cleaning sponge; 30-Spring. Detailed Implementation

[0018] like Figures 1 to 3 As shown, this specific embodiment adopts the following technical solution: a polypeptide biosynthesis reactor that is easy to clean, including a base 1, a reactor body 2, support legs 3, valves 4, a reactor cover 5, locking bolts 6, nuts 7, a casing 8, a first motor 9, a lead screw 10, a bearing seat 11, a lifting block 12, a slot 13, a lifting bracket 14, and a cleaning and stirring assembly; several support legs 3 are fixedly connected to the lower surface of the reactor body 2, and the support legs 3 are fixedly connected to the left side of the upper surface of the base 1; a valve 4 is connected to the bottom end of the reactor body 2; a reactor cover 5 is provided on the reactor body 2, and the reactor body 2 and the reactor cover 5 are connected by locking bolts 6. The nut 7 is locked in place; a cover 8 is fixedly connected to the right side of the upper surface of the base 1; a first motor 9 is fixedly connected to the bottom surface of the cavity of the cover 8; a bearing seat 11 is fixedly connected to the top surface of the cavity of the cover 8; slots 13 are provided on both sides of the cover 8; a lead screw 10 is fixedly connected to the output end of the first motor 9; the other end of the lead screw 10 is movably connected to the bearing seat 11; a lifting block 12 is threadedly connected to the lead screw 10; the two ends of the lifting block 12 are slidably connected to the slots 13; a lifting bracket 14 is fixedly connected to both ends of the lifting block 12; a cleaning and stirring assembly is connected to the lifting bracket 14.

[0019] like Figures 1 to 3 As shown, the specific structure of the cleaning and stirring assembly includes a second motor 15, a rotating arm 16, a third motor 17, a rotating shaft 18, a stirring rod 19, a column 20, a rotating rod 21, a bearing 22, a first gear 23, a fourth motor 24, a second gear 25, a connecting rod 26, a first cleaning sponge 27, an inner tube 28, a second cleaning sponge 29, and a spring 30; the second motor 15 is fixedly connected to the top of the lifting bracket 14; the rotating arm 16 is fixedly connected to the output end of the second motor 15; the third motor 17 is fixedly connected to the left side of the lower surface of the rotating arm 16, the rotating shaft 18 is fixedly connected to the output end of the third motor 17, and several stirring rods 19 are fixedly connected to the rotating shaft 18; A column 20 is fixedly connected to the right side of the lower surface of the rotating arm 16. A rotating rod 21 is movably connected to the end of the column 20 via a bearing 22. A first gear 23 is fixedly connected to the top of the rotating rod 21. A fourth motor 24 is fixedly connected to the side of the end of the column 20. A second gear 25 is fixedly connected to the output end of the fourth motor 24. The second gear 25 meshes with the first gear 23. A first cleaning sponge 27 is fixedly connected to both sides of the rotating rod 21 via a connecting rod 26. An inner tube 28 is connected to the end of the rotating rod 21. A spring 30 is fixedly connected between the inner tube 28 and the rotating rod 21. A second cleaning sponge 29 is fixedly connected to the end of the inner tube 28.

[0020] The first cleaning sponge 27 and the second cleaning sponge 29 are made of corrosion-resistant fiber material and have dense embossed texture on their surfaces to improve cleaning efficiency; the contact surface between the reactor lid 5 and the reactor body 2 is provided with an annular sealing ring to improve sealing performance; the bottom of the base 1 is provided with an anti-slip rubber pad to enhance equipment stability; and both the first gear 23 and the second gear 25 are coated with grease.

[0021] The usage state of this utility model is as follows: Loosen the locking bolt 6 and nut 7 to open the reactor lid 5. During normal operation, the stirring rod 19 on the rotating shaft 18 can be used to stir the liquid as a stirring device. When cleaning is required, add cleaning solution to the reactor body 2. The third motor 17 drives the rotating shaft 18 and stirring rod 19 to rotate at high speed to stir the cleaning solution and enhance the rinsing effect. This is suitable for preliminary cleaning after the reaction. After preliminary cleaning, start the first motor 9. Its output shaft drives the lead screw 10 to rotate. Through the threaded transmission, the lifting block 12 slides upward along the slot 13, driving the lifting bracket 14 to the highest position. The second motor 15 starts, driving the rotation... Arm 16 rotates around its axis, causing stirring rod 19 and rotating rod 21 to move in a circular motion synchronously. After the positions of stirring rod 19 and rotating rod 21 are reversed, the first motor 9 drives the lifting bracket 14 downward, lowering column 21 so that the first cleaning sponge 27 and the second cleaning sponge 29 extend into the reactor body 2. The fourth motor 24 drives the rotating rod 21 to rotate at high speed through the meshing of the second gear 25 and the first gear 23. The first cleaning sponges 27 on both sides adhere tightly to the inner wall of the reactor along with the connecting rod 26, performing a circular wiping to remove residual impurities. The inner tube 28 at the end of the rotating rod 21 is connected to the rotating rod through spring 30, and the second cleaning sponge 29 extends out along with the inner tube. When the cleaning assembly moves to the bottom of the reactor, spring 30 is compressed and contracts, causing the second cleaning sponge 29 to adaptively conform to the bottom curvature, reaching deep into corner areas and solving the problem of traditional cleaning dead corners. After cleaning, the first motor 9 rotates, causing the lifting bracket 14 to return to its highest position and exit the reactor body 2. The valve 4 is opened, and the cleaning waste liquid is discharged through the bottom of the reactor body 2, completing the entire cleaning process.

[0022] In the description of this utility model, it should be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "side", "top", "inner", "front", "center", "both ends", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0023] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "setting", "connection", "fixing", "screw connection", etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0024] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications may be made to this utility model without departing from its spirit and scope. All such changes and modifications fall within the scope of protection of this utility model as defined by the appended claims and their equivalents.

[0025] The control method of this utility model is to control the device by manually starting and stopping the switch. The wiring diagram of the power element and the supply of power are common knowledge in the field. Since this utility model is mainly used to protect mechanical devices, the control method and wiring layout will not be explained in detail.

Claims

1. A polypeptide biosynthesis reaction vessel that facilitates cleaning, characterized by: Includes base (1), reactor body (2), support leg (3), valve (4), reactor cover (5), locking bolt (6), nut (7), cover (8), first motor (9), lead screw (10), bearing seat (11), lifting block (12), slot (13), lifting bracket (14) and cleaning and stirring assembly; Several support legs (3) are fixedly connected to the lower surface of the reactor body (2), and the support legs (3) are fixedly connected to the left side of the upper surface of the base (1); A valve (4) is connected to the bottom end of the reactor body (2); The reactor body (2) is provided with a reactor cover (5), and the reactor body (2) and the reactor cover (5) are locked together by locking bolts (6) and nuts (7); A cover (8) is fixedly connected to the right side of the upper surface of the base (1). A first motor (9) is fixedly connected to the bottom surface of the cavity of the cover (8). A bearing seat (11) is fixedly connected to the top surface of the cavity of the cover (8). Slots (13) are provided on both sides of the cover (8). A lead screw (10) is fixedly connected to the output end of the first motor (9), and the other end of the lead screw (10) is movably connected in the bearing seat (11); The lead screw (10) is connected to a lifting block (12) by a thread, and the two ends of the lifting block (12) are slidably connected in the slot (13); Lifting brackets (14) are fixedly connected to both ends of the lifting block (12), and a cleaning and stirring assembly is connected to the lifting brackets (14).

2. The easy-to-clean polypeptide biosynthesis reactor according to claim 1, characterized in that: The specific structure of the cleaning and stirring assembly includes a second motor (15), a rotating arm (16), a third motor (17), a rotating shaft (18), a stirring rod (19), a column (20), a rotating rod (21), a bearing (22), a first gear (23), a fourth motor (24), a second gear (25), a connecting rod (26), a first cleaning sponge (27), an inner tube (28), a second cleaning sponge (29), and a spring (30). The second motor (15) is fixedly connected to the top of the lifting bracket (14); A rotating arm (16) is fixedly connected to the output end of the second motor (15). A third motor (17) is fixedly connected to the left side of the lower surface of the rotating arm (16). A rotating shaft (18) is fixedly connected to the output end of the third motor (17). Several stirring rods (19) are fixedly connected to the rotating shaft (18). A column (20) is fixedly connected to the right side of the lower surface of the rotating arm (16), and a rotating rod (21) is movably connected to the end of the column (20) through a bearing (22). A first gear (23) is fixedly connected to the top of the rotating rod (21); A fourth motor (24) is fixedly connected to the side of the end of the column (20), and a second gear (25) is fixedly connected to the output end of the fourth motor (24). The second gear (25) meshes with the first gear (23). The first cleaning sponge (27) is fixedly connected to both sides of the rotating rod (21) by the connecting rod (26). An inner tube (28) is connected to the end of the rotating rod (21), and a spring (30) is fixedly connected between the inner tube (28) and the rotating rod (21). A second cleaning sponge (29) is fixedly connected to the end of the inner tube (28).

3. The easy-to-clean polypeptide biosynthesis reactor according to claim 2, characterized in that: The first cleaning sponge (27) and the second cleaning sponge (29) are made of corrosion-resistant fiber material, and the surface is provided with dense embossed texture to improve cleaning efficiency.

4. The easy-to-clean polypeptide biosynthesis reactor according to claim 1, characterized in that: The contact surface between the reactor lid (5) and the reactor body (2) is provided with an annular sealing ring to improve the sealing performance.

5. The easy-to-clean polypeptide biosynthesis reactor according to claim 1, characterized in that: The base (1) has an anti-slip rubber pad at the bottom to enhance the stability of the equipment.

6. The easy-to-clean polypeptide biosynthesis reactor according to claim 2, characterized in that: Both the first gear (23) and the second gear (25) are coated with grease.

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