Chemiluminescence magnetic separation mixing mechanism

Abstract

This utility model discloses a chemiluminescence magnetic separation and mixing mechanism, applied in the field of chemiluminescence immunoassay technology. It includes a base plate with a track bolted to its top. A base is slidably connected to the top of the track. A first motor is bolted to the right side of the base, and a gear is engaged at the bottom of the first motor. A rack is formed on the inner wall of the base plate, with the gear surface meshing with the rack surface. A vertical plate is bolted to the top of the back of the base plate, and a liquid injection assembly is installed on the left side of the vertical plate. A groove is welded to the back of the vertical plate, and a sliding bracket is engaged on the surface of the groove. A placement platform is bolted to the front of the sliding bracket, and a liquid suction needle assembly is engaged on the inner wall of the placement platform. The disc-type structure is designed as a linear structure, simplifying the design. Liquid injection and drainage devices are set along the movement path of the reaction cup. Simultaneously, the gear and rack mechanism of the reaction cup movement enables the mixing function to be completed during the movement of the reaction cup between positions.

Description

Technical Field

[0001] This utility model belongs to the field of chemiluminescence immunoassay technology, and specifically relates to a chemiluminescence magnetic separation and mixing mechanism. Background Technology

[0002] Chemiluminescence immunoassay is a widely used clinical testing technique. Its principle involves coating analyte molecules with magnetic beads, separating and washing away unreacted free components, and then adding a luminescent substrate for analysis. Magnetic separation and mixing is a crucial step, requiring repeated washing to remove unbound free labels and other interfering impurities. Existing technologies mostly use a disc-type structure, with injection, drainage, and mixing devices at corresponding reaction cup locations for magnetic separation, mixing, and cleaning. This structure is complex, space-consuming, costly, and inconvenient to maintain. There is an urgent need to develop a more convenient device to address these issues. Utility Model Content

[0003] The purpose of this invention is to provide a chemiluminescent magnetic separation and mixing mechanism, the advantage of which is that the disc-type structure is designed as a straight-line structure, which simplifies the design and facilitates the adjustment of the lifting angle by using belt power.

[0004] The above-mentioned technical objective of this utility model is achieved through the following technical solution: a chemiluminescent magnetic separation and mixing mechanism, comprising a base plate, a track bolted to the top of the base plate, a base slidably connected to the top of the track, a first motor bolted to the right side of the base, a gear engaged at the bottom of the first motor, a rack formed on the inner wall of the base plate, with the surface of the gear meshing with the surface of the rack, a vertical plate bolted to the top of the back of the base plate, a liquid injection assembly installed on the left side of the vertical plate, a groove welded to the back of the vertical plate, a sliding bracket engaged on the surface of the groove, a placement platform bolted to the front of the sliding bracket, and a liquid suction needle assembly engaged on the inner wall of the placement platform.

[0005] The above technical solution is adopted as follows: by starting the first motor, the gear rotates on the rack surface, causing the base to move back and forth on the slide surface, driving the rotating gear to rotate, causing the upper and lower rotating rods to rotate, and simultaneously driving the upper and lower bearings to rotate, rotating and shaking the reaction cup in the clamping interface on the inner wall of the upper rotating rod to fuse the liquid in the reaction cup. By setting a vertical plate and welding a groove on the back of the vertical plate, the sliding bracket is clamped to the surface of the groove. After the second motor is started, it realizes up and down movement to drive the liquid suction needle assembly to operate. At the same time, a liquid injection assembly is set at one end of the left side of the vertical plate.

[0006] The present invention is further configured such that the liquid injection assembly includes a substrate injection tube, and a cleaning fluid injection tube is installed on the left side of the substrate injection tube.

[0007] The above technical solution is adopted as follows: by setting up a liquid injection assembly, which includes a liquid injection tube and a cleaning tube, the reaction cup is moved to the end of the liquid injection tube during operation, and liquid flows into the reaction cup through the liquid injection tube. After the liquid in the reaction cup is drawn out by the liquid aspiration needle, the reaction cup is moved to the end of the cleaning tube, and cleaning solution is introduced through the cleaning tube to clean the reaction cup.

[0008] The present invention is further configured such that the aspirator assembly includes a snap-fit ​​shell, an aspirator is installed on the inner wall of the snap-fit ​​shell, a retaining shell is snapped into the bottom of the snap-fit ​​shell, and a spring is installed on the inner wall of the snap-fit ​​shell.

[0009] The above technical solution is adopted: the aspiration needle assembly consists of a snap-fit ​​shell, an aspiration needle, a retaining shell, and a spring. The retaining shell is installed at the bottom of the placement platform, the spring is placed inside the snap-fit ​​shell, and the snap-fit ​​shell is installed at the top of the placement platform and snapped and fixed with the retaining shell. Then the aspiration needle is inserted for use.

[0010] The present invention is further configured such that a second motor is bolted to the back of the base plate, a belt is sleeved on the back surface of the second motor, and an assist rod is sleeved on the inner wall of the top of the belt.

[0011] The above technical solution is adopted: by bolting a second motor, after the second motor is started, it drives the belt, and the belt drives the booster rod to move up and down, so that the sliding bracket can drive the placement platform and the liquid suction needle assembly on the inner wall of the placement platform to move up and down to perform liquid suction operation.

[0012] The present invention is further configured such that a lower bearing and an upper bearing are snapped into the bottom left side of the base, and a lower rotating rod is snapped into the bottom of the lower bearing.

[0013] The above technical solution is adopted: by setting up a lower bearing and an upper bearing, when the first motor drives the gear to rotate on the surface of the rack, the front and rear power drives the rotating gear to move back and forth, so that the lower rotating rod and the upper rotating rod simultaneously drive the upper bearing and the lower bearing to rotate in the rotation operation, thereby driving the reaction cup to rotate, thereby shaking the liquid in the reaction cup to fuse.

[0014] The present invention is further configured such that a rotating gear is engaged at the bottom of the lower rotating rod, and the surface of the rotating gear meshes with the surface of the rack.

[0015] The above technical solution is adopted: by setting a rotating gear, after the first motor runs, the front and rear power generated by the rotation of the gear of the first motor on the rack surface drives the rotating gear to rotate, thereby achieving front and rear adjustment and shaking the liquid in the reaction cup during rotation.

[0016] The present invention is further configured such that an upper rotating rod is snapped onto the top of the upper bearing, and a reaction cup interface is provided on the inner wall of the upper rotating rod.

[0017] The above technical solution is adopted as follows: by setting an upper rotating rod, the lower rotating rod, lower bearing, and upper bearing are driven to run together during the operation of the rotating gear, providing power for rotation and forward and backward angle, driving the upper rotating rod to rotate at the same time, so that the reaction cup fixedly placed in the card interface rotates accordingly, and the liquid in the reaction cup is shaken evenly.

[0018] The present invention is further configured such that a power-assisted handle is snapped onto the surface of the belt, and the left side of the power-assisted handle is bolted to the right side of the sliding bracket.

[0019] The above technical solution involves starting the second motor, which drives the belt to run, and with the assistance of the booster rod, it achieves lifting and lowering. At the same time, the booster handle can drive the sliding bracket to move up and down, so that the suction needle can be raised and lowered to perform suction work.

[0020] In summary, this utility model has the following beneficial effects:

[0021] 1. By designing the disc-type structure as a straight-line structure, the design is simplified. Liquid injection and drainage devices are set on the movement path of the reaction cup. At the same time, the gear and rack mechanism of the reaction cup movement is used to realize the mixing function during the movement of the reaction cup between positions. All actions of the entire module are visible, which is convenient for debugging and maintenance.

[0022] 2. By using a second motor to drive the rotating rod, the belt moves and the assist rod is raised and lowered, which in turn allows the assist handle on the belt surface to move the sliding bracket up and down, facilitating the raising and lowering of the suction needle for liquid suction and easy adjustment. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0024] Figure 2 This is a partial exploded view of the structure of this utility model;

[0025] Figure 3 This is a partial structural rear view of the present invention;

[0026] Figure 4 This is a schematic diagram of the rear of a partial structure of this utility model;

[0027] Figure 5 This is a partial front cross-sectional view of the structure of this utility model.

[0028] Reference numerals: 1. Base plate; 2. Track; 3. Base; 4. First motor; 5. Gear; 6. Rack; 7. Vertical plate; 8. Injection assembly; 801. Substrate injection tube; 802. Cleaning fluid injection tube; 9. Groove; 10. Sliding bracket; 11. Placement platform; 12. Suction needle assembly; 121. Snap-fit ​​shell; 122. Suction needle; 123. Retention shell; 124. Spring; 13. Second motor; 14. Belt; 15. Auxiliary rod; 16. Lower bearing; 17. Upper bearing; 18. Lower rotating rod; 19. Rotating gear; 20. Upper rotating rod; 21. Reaction cup interface; 22. Auxiliary handle. Detailed Implementation

[0029] The present invention will be further described in detail below with reference to the accompanying drawings.

[0030] Example 1:

[0031] refer to Figure 1 , Figure 2 A chemiluminescent magnetic separation and mixing mechanism includes a base plate 1, a track 2 bolted to the top of the base plate 1, a base 3 slidably connected to the top of the track 2, a first motor 4 bolted to the right side of the base 3, a gear 5 engaged at the bottom of the first motor 4, and a rack 6 formed on the inner wall of the base plate 1, with the surface of the gear 5 meshing with the surface of the rack 6. After the first motor 4 is started, the gear 5 reciprocates on the rack 6, simultaneously driving a rotating gear 9 to rotate. Driven by the rotating gear 9, the lower bearing 16, the lower rotating rod 18, the upper bearing 17, and the upper rotating rod 20 rotate, thereby causing the reaction cup fixedly installed in the interface to rotate and shake, so that the liquid in the reaction cup is shaken and mixed.

[0032] refer to Figure 1 , Figure 2 The lower bearing 16 and the upper bearing 17 are snapped into the bottom left side of the base 3. The lower bearing 16 is snapped into the bottom of the lower rotating rod 18. With the lower bearing 16 and the upper bearing 17 in place, when the first motor 4 drives the gear 5 to rotate on the surface of the rack 6, the forward and backward power drives the rotating gear 19 to move back and forth, so that the lower rotating rod 18 and the upper rotating rod 20 simultaneously drive the upper bearing 17 and the lower bearing 16 to rotate in the rotation operation, thereby driving the reaction cup to rotate, thus shaking the liquid in the reaction cup to fuse.

[0033] Referring to the figure, a rotating gear 19 is engaged at the bottom of the lower rotating rod 18, and the surface of the rotating gear 19 meshes with the surface of the rack 6. The rotating gear 19 is set so that when the first motor 4 is running, the forward and backward force generated by the rotation of the gear 5 of the first motor 4 on the surface of the rack 6 drives the rotating gear 19 to rotate, thereby achieving forward and backward adjustment and shaking the liquid in the reaction cup during rotation.

[0034] Referring to the figure, the upper bearing 17 is snapped with an upper rotating rod 20 at its top. The inner wall of the upper rotating rod 20 has a reaction cup interface 21. When the rotating gear 19 is running, the upper rotating rod 20 drives the lower rotating rod 18, the lower bearing 16, and the upper bearing 17 to run together, providing power for rotation and forward and backward angle, driving the upper rotating rod 20 to rotate simultaneously. This causes the reaction cup, which is fixedly placed in the reaction cup interface 21, to rotate and shake the liquid in the reaction cup.

[0035] Brief description of the usage process: A track 2 is set on the top of the base plate 1, and a first motor 4 is bolted to the top of the track 2. At the same time, a rack 6 is set on the inner wall of the base plate 1. After the first motor 4 is started, the gear 5 rotates on the surface of the rack 6, thereby driving the rotating gear 19 to rotate back and forth. Through the operation of the rotating gear 19, the lower rotating rod 18 drives the lower bearing 16 to rotate, thereby causing the upper bearing 17 and the upper rotating rod 20 to run. When the first motor 4 reciprocates, the reaction cup in the reaction cup interface 21 shakes, and the liquid in the reaction cup is shaken evenly.

[0036] Example 2:

[0037] refer to Figure 1 , Figure 3 , Figure 4 A chemiluminescent magnetic separation and mixing mechanism includes a base plate 1, a vertical plate 7 bolted to the top of the back of the base plate 1, a liquid injection component 8 installed on the left side of the vertical plate 7, a groove 9 welded to the back of the vertical plate 7, a sliding bracket 10 snapped onto the surface of the groove 9, a placement platform 11 bolted to the front of the sliding bracket 10, and a liquid suction needle component 12 snapped onto the inner wall of the placement platform 11. The groove 9 is welded to the back of the vertical plate 7, and the sliding bracket 10 is snapped onto the surface of the groove 9. After the second motor 13 is started, it moves up and down to drive the liquid suction needle component 12 to operate. At the same time, the liquid injection component 12 is set at one end of the left side of the vertical plate 7.

[0038] refer to Figure 3 , Figure 4 The liquid injection assembly 8 includes a substrate injection tube 801, and a cleaning fluid injection tube 802 is installed on the left side of the substrate injection tube 801. The liquid injection assembly 8 includes the substrate injection tube 801 and the cleaning fluid injection tube 802. During operation, the reaction cup is moved to the end of the cleaning fluid injection tube 802, and liquid flows into the reaction cup through the cleaning fluid injection tube 802. Then, a mixing action is performed, and the liquid in the reaction cup is drawn out by the suction needle 122. The reaction cup is continuously cleaned multiple times according to the time sequence requirements. The reaction cup is moved to the end of the substrate injection tube 801, and the substrate is injected through the substrate injection tube 801.

[0039] refer to Figure 3 , Figure 4The aspiration needle assembly 12 includes a snap-fit ​​housing 121, an aspiration needle 122 installed on the inner wall of the snap-fit ​​housing 121, a retaining housing 123 snapped into the bottom of the snap-fit ​​housing 121, and a spring 124 installed on the inner wall of the snap-fit ​​housing 121. The aspiration needle assembly 12 consists of the snap-fit ​​housing 121, the aspiration needle 122, the retaining housing 123, and the spring 124. After the retaining housing is installed at the bottom of the placement platform 11, the spring 124 is placed inside the snap-fit ​​housing 121, and the snap-fit ​​housing 121 is installed at the top of the placement platform 11 and snapped into the retaining housing 123, the aspiration needle 122 is placed in for use.

[0040] refer to Figure 5 A second motor 13 is bolted to the back of the base plate 1. A belt 14 is sleeved on the back surface of the second motor 13. An assist rod 15 is sleeved on the inner wall of the top of the belt 14 and bolted to the second motor 13. After the second motor 13 is started, it drives the belt 14. The belt 14 drives the assist rod 15 to move up and down, so that the sliding bracket 10 can drive the placement platform 11 and the liquid suction needle assembly 12 on the inner wall of the placement platform 11 to move up and down to perform liquid suction operation.

[0041] refer to Figure 5 A power-assisted handle 22 is attached to the surface of the belt 14, and the left side of the power-assisted handle 22 is bolted to the right side of the sliding bracket 10. When the second motor 13 is started, the belt 14 is driven to run. With the assistance of the power-assisted rod 15, the belt 14 can move up and down. At the same time, the power-assisted handle 22 can drive the sliding bracket 10 to move up and down, so that the suction needle 122 can move up and down to perform suction work.

[0042] Brief description of the operation: The first motor 4 carries the reaction cup to the cleaning fluid injection pipe 802 on the liquid injection assembly 8. The cleaning fluid is injected into the reaction cup through the cleaning fluid injection pipe 802. Then, driven by the first motor 4, the reaction cup is shaken to mix the liquid. After mixing, the reaction cup is moved to the bottom of the 12 drain needle assembly under the first motor 4. The magnetic beads in the reaction cup are attracted by the magnet. Then, the second motor 13 is started, driving the belt 14 to move. The belt drives the assist rod 15 to move, thereby realizing the lifting and lowering operation. A groove 9 is set on the back of the vertical plate 7. After the sliding bracket 10 is engaged with the groove 9, the assist handle 22 driven by the belt 14 begins to move up and down, so that the sliding bracket 10 can move up and down. The placement platform 11 on the front of the sliding bracket 10 and the suction needle assembly 12 move up and down, so that the suction needle 122 can descend to suction the liquid. After suction is completed, it rises. The above steps are repeated to complete the multi-step cleaning operation. Then, the first motor 4 carries the reaction cup to the substrate injection tube 801 on the injection assembly 8. The substrate is injected into the reaction cup through the substrate injection tube 801. Then, the reaction cup is picked up by the gripper, mixed, and placed into the detection module for detection.

[0043] This specific embodiment is merely an explanation of the present utility model and is not intended to limit the present utility model. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but as long as they are within the scope of the claims of the present utility model, they are protected by patent law.

Claims

1. A chemiluminescence magnetic separation mixing mechanism comprising a base plate (1), characterized in that: The top of the base plate (1) is bolted with a track (2), the top of the track (2) is slidably connected with a base (3), the right side of the base (3) is bolted with a first motor (4), the bottom of the first motor (4) is engaged with a gear (5), the inner wall of the base plate (1) is provided with a rack (6), and the surface of the gear (5) meshes with the surface of the rack (6). The top of the back of the base plate (1) is bolted with a vertical plate (7), the left side of the vertical plate (7) is equipped with an injection assembly (8), the back of the vertical plate (7) is welded with a groove (9), the surface of the groove (9) is engaged with a sliding bracket (10), the front of the sliding bracket (10) is bolted with a placement platform (11), and the inner wall of the placement platform (11) is engaged with a suction needle assembly (12).

2. The chemiluminescence magnetic separation mixing mechanism according to claim 1, wherein: The liquid injection assembly (8) includes a substrate injection tube (801), and a cleaning fluid injection tube (802) is installed on the left side of the substrate injection tube (801).

3. The chemical luminescence magnetic separation mixing mechanism according to claim 1, characterized in that: The aspiration needle assembly (12) includes a snap-fit ​​shell (121), an aspiration needle (122) is installed on the inner wall of the snap-fit ​​shell (121), a retaining shell (123) is snapped into the bottom of the snap-fit ​​shell (121), and a spring (124) is installed on the inner wall of the snap-fit ​​shell (121).

4. The chemiluminescent magnetic separation mixing mechanism according to claim 1, wherein: A second motor (13) is bolted to the back of the base plate (1), and a belt (14) is sleeved on the back surface of the second motor (13). An assist rod (15) is sleeved on the top inner wall of the belt (14).

5. The chemiluminescent magnetic separation mixing mechanism according to claim 1, wherein: The base (3) has a lower bearing (16) and an upper bearing (17) attached to its left bottom, and a lower rotating rod (18) is attached to the bottom of the lower bearing (16).

6. The chemiluminescent magnetic separation mixing mechanism according to claim 5, wherein: The bottom of the lower rotating rod (18) is engaged with a rotating gear (19), and the surface of the rotating gear (19) meshes with the surface of the rack (6).

7. The chemical luminescence magnetic separation mixing mechanism according to claim 5, characterized in that: The upper bearing (17) is fitted with an upper rotating rod (20) at the top, and the upper rotating rod (20) has a reaction cup interface (21) on its inner wall.

8. The chemiluminescent magnetic separation mixing mechanism according to claim 4, wherein: The surface of the belt (14) is fitted with a power-assisted handle (22), and the left side of the power-assisted handle (22) is bolted to the right side of the sliding bracket (10).

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