A magnetic bead-based nucleic acid extractor

Abstract

This utility model discloses a magnetic bead-based nucleic acid extractor, comprising: a worktable; a support plate fixedly connected to the upper surface of the worktable; a lead screw rotatably connected to the inner surface of the support plate; a support platform threadedly connected to the outer surface of the lead screw; a magnetic rod sleeve movably connected to the inner surface of the support platform; a magnetic rod housing fixedly connected to the lower surface of the magnetic rod sleeve; the number of magnetic rod housings being replaceable; a support plate fixedly connected to the upper surface of the support platform; a lead screw rotatably connected to the inner surface of the support plate; and a support platform rotatably connected to the outer surface of the lead screw. This structure solves the throughput limitation problem caused by the fixed magnetic rods and housings in traditional equipment, allowing for flexible adaptation to different sample volumes and containers. The dual-motor drive solves the problems of low operating efficiency and large errors, improving automation and stability.

Description

Technical Field

[0001] This utility model relates to the field of magnetic bead nucleic acid extraction technology, and in particular to a magnetic bead nucleic acid extractor. Background Technology

[0002] In the field of magnetic bead-based nucleic acid extraction, traditional extraction equipment typically employs a fixed arrangement and number of integrated magnetic rods and shells, severely limiting extraction throughput and compatibility with container specifications. For example, equipment designed for 96-well plates can only process samples with that specific number of wells. Processing 24-well plates, single-tube samples, or small batches requires additional specialized equipment, increasing laboratory costs, high equipment idle rates, and significant space occupation. Furthermore, the coordination of the magnetic rods and shells, as well as the overall sample entry and exit operations, often rely on manual assistance or a single drive structure. This results in cumbersome procedures, poor consistency in magnetic bead adsorption / release, and susceptibility to human intervention or mechanical instability affecting nucleic acid extraction purity and efficiency. Consequently, it fails to meet the diverse demands for sample processing flexibility, automation, and low cost in clinical testing and research experiments. Utility Model Content

[0003] The purpose of this invention is to solve at least one of the technical problems existing in the prior art, and to provide a magnetic bead nucleic acid extractor. This solves the problem of limited throughput caused by the fixation of magnetic rods and shells in traditional equipment. It can be flexibly adapted to different sample volumes and containers. The dual-motor drive solves the problems of low operating efficiency and large error, and improves automation and stability.

[0004] This utility model also provides a magnetic bead-based nucleic acid extractor, comprising: a worktable; a support plate fixedly connected to the upper surface of the worktable; a lead screw rotatably connected to the inner surface of the support plate; a support platform threadedly connected to the outer surface of the lead screw; a magnetic rod sleeve plate movably connected to the inner surface of the support platform; a magnetic rod shell fixedly connected to the lower surface of the magnetic rod sleeve plate; the number of magnetic rod shells is replaceable; a support plate two fixedly connected to the upper surface of the support platform; a lead screw two rotatably connected to the inner surface of the support plate two; a support platform two rotatably connected to the outer surface of the lead screw two; a magnetic rod plate movably connected to the inner surface of the support platform two; and magnetic rod bodies fixedly connected to the lower surface of the magnetic rod plate; the number of magnetic rod bodies is replaceable.

[0005] Preferably, the shape of the magnetic rod body is the same as the internal shape of the magnetic rod shell, and the magnetic rod body is movably connected to the magnetic rod shell to protect the magnetic rod body.

[0006] Preferably, a motor is fixedly connected to the upper surface of the support plate, and the motor drives the lead screw to rotate, thereby moving the support platform.

[0007] Preferably, a motor is fixedly connected to the upper surface of the second support plate, and the second motor drives the second lead screw to rotate, thereby moving the second support platform.

[0008] Preferably, a fixing groove is fixedly connected to the upper surface of the worktable, and a fixing plate is rotatably connected to the front surface of the fixing groove to fix the sample to be extracted.

[0009] Preferably, the magnetic rod plate and the second support platform are limited by a slot, and the magnetic rod plate can be removed and replaced by pulling it out.

[0010] Preferably, the magnetic rod sleeve and the support platform are fixed and limited by a slot, and the magnetic rod sleeve can be pulled out and replaced for easy replacement and fixation.

[0011] Beneficial effects: The magnetic rods and magnetic rod shells can be replaced with different arrangements and numbers, which realizes flexible adjustment of extraction throughput. It can meet the needs of rapid processing of small batches of samples and cope with large-scale batch detection. At the same time, the automated operation of driving the whole into the sample with motor one and controlling the magnetic rods to be put into the magnetic rod shell with motor two reduces the error caused by manual intervention, improves the stability and repeatability of nucleic acid extraction, and prevents the magnetic rods from being contaminated.

[0012] This technical solution provides a magnetic bead-based nucleic acid extractor. Depending on the required arrangement and quantity of magnetic rods and magnetic rod housings, a second motor drives the magnetic rods to be inserted into the magnetic rod housings, while a first motor drives the entire unit into the sample for extraction. Attached Figure Description

[0013] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0014] Figure 1 This is a front view structural diagram of a magnetic bead-based nucleic acid extractor according to this utility model;

[0015] Figure 2 This is a side view of a magnetic bead-based nucleic acid extractor according to the present invention.

[0016] Figure 3 This is a bottom view of the structure of a magnetic bead-based nucleic acid extractor according to this utility model;

[0017] Figure 4 This is a top view of a magnetic bead-based nucleic acid extractor according to this utility model.

[0018] Legend:

[0019] 1. Workbench; 2. Support plate one; 3. Lead screw one; 4. Motor one; 5. Support platform one; 6. Support plate two; 7. Lead screw two; 8. Motor two; 9. Support platform two; 10. Magnetic rod plate; 11. Magnetic rod body; 12. Magnetic rod sleeve plate; 13. Magnetic rod casing; 14. Fixing groove; 15. Fixing plate. Detailed Implementation

[0020] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0021] Reference Figure 1-4 This utility model discloses a magnetic bead-based nucleic acid extractor, comprising: a worktable 1; a support plate 2 fixedly connected to the upper surface of the worktable 1; a lead screw 3 rotatably connected to the inner surface of the support plate 2; and a motor 4 fixedly connected to the upper surface of the support plate 2, which drives the lead screw 3 to rotate. A support platform 5 is threadedly connected to the outer surface of the lead screw 3; a magnetic rod sleeve 12 is movably connected to the inner surface of the support platform 5, and the magnetic rod sleeve 12 is fixedly positioned with the support platform 5 via a slot. The magnetic rod sleeve 12 can be pulled out and replaced. A magnetic rod housing 13 is fixedly connected to the lower surface of the magnetic rod sleeve 12, and the number of magnetic rod housings 13 can be changed.

[0022] Specifically: Select the corresponding number and arrangement of magnetic rod sleeves 13 and magnetic rod plates 12, align the magnetic rod plates 12 with the slots of the support platform 5, push them in and fix them in place through the slots; start the motor 4, which drives the lead screw 3 to rotate, causing the support platform 5 to move down along the support plate 2, and simultaneously driving the magnetic rod plates 12 and magnetic rod sleeves 13 into the sample container for extraction.

[0023] A support plate 6 is fixedly connected to the upper surface of support platform 1 5. A lead screw 7 is rotatably connected to the inner surface of support plate 2 6. A motor 8 is fixedly connected to the upper surface of support plate 2 6, and motor 8 drives lead screw 7 to rotate. A support platform 9 is rotatably connected to the outer surface of lead screw 2 7. A magnetic rod plate 10 is movably connected to the inner surface of support platform 2 9. The magnetic rod plate 10 and support platform 2 9 are limited by a slot. The magnetic rod plate 10 can be pulled out and replaced. A magnetic rod body 11 is fixedly connected to the lower surface of magnetic rod plate 10. The number of magnetic rod bodies 11 can be changed. The shape of the magnetic rod body 11 is the same as the internal shape of the magnetic rod housing 13, and the magnetic rod body 11 is movably connected to the magnetic rod housing 13. A fixing groove 14 is fixedly connected to the upper surface of worktable 1. A fixing plate 15 is rotatably connected to the front surface of fixing groove 14.

[0024] Specifically: Based on the number and arrangement of the magnetic rod housings 13, select the corresponding specifications of magnetic rod bodies 11 and magnetic rod plates 10, and limit the magnetic rod plates 10 within the support platform 2 9 through the slots; start the motor 2 8, which drives the lead screw 2 7 to rotate, causing the support platform 2 9 to move down along the support plate 2 6, and driving the magnetic rod bodies 11 to be precisely fitted into the magnetic rod housings 13 with matching shapes; place the sample container into the fixing slot 14 on the worktable 1, and rotate the fixing plate 15 to fasten and fix it; when the motor 1 drives the support platform 1 5 to move down, the magnetic rod housings 13 and magnetic rod bodies 11 enter the sample, and the magnetic beads are adsorbed by the magnetic field to complete the extraction. The dual motors work together to achieve precise operation.

[0025] Working principle: Select the corresponding number and arrangement of magnetic rod sleeves 13 and magnetic rod plates 12, align the magnetic rod plates 12 with the slots of the support platform 5, push them in and fix them in the slots; start the motor 4, which drives the lead screw 3 to rotate, causing the support platform 5 to move down along the support plate 2, and simultaneously drive the magnetic rod plates 12 and magnetic rod sleeves 13 into the sample container for extraction. Based on the number and arrangement of the magnetic rod housings 13, select the corresponding specifications of magnetic rod bodies 11 and magnetic rod plates 10, and limit the magnetic rod plates 10 within the support platform 9 through the slots; start the motor 8, which drives the lead screw 7 to rotate, causing the support platform 9 to move down along the support plate 6, and driving the magnetic rod bodies 11 to be precisely fitted into the matching magnetic rod housings 13; place the sample container into the fixing slot 14 on the worktable 1, and rotate the fixing plate 15 to fasten and fix it; when the motor drives the support platform 5 to move down, the magnetic rod housings 13 and magnetic rods 11 enter the sample, and the magnetic beads are extracted by magnetic field adsorption. The dual motors work together to achieve precise operation.

[0026] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A magnetic bead method nucleic acid extractor characterized by comprising: include: A workbench (1) is fixedly connected to a support plate (2) on its upper surface. A lead screw (3) is rotatably connected to the inner surface of the support plate (2). A support platform (5) is threaded through the outer surface of the lead screw (3). A magnetic rod sleeve (12) is movably connected to the inner surface of the support platform (5). A magnetic rod shell (13) is fixedly connected to the lower surface of the magnetic rod sleeve (12). The number of magnetic rod shells (13) can be changed. A support plate (6) is fixedly connected to the upper surface of the support platform (5). A lead screw (7) is rotatably connected to the inner surface of the support plate (6). A support platform (9) is rotatably connected to the outer surface of the lead screw (7). A magnetic rod plate (10) is movably connected to the inner surface of the support platform (9). A magnetic rod body (11) is fixedly connected to the lower surface of the magnetic rod plate (10). The number of magnetic rod bodies (11) can be changed.

2. The magnetic bead method nucleic acid extractor according to claim 1, characterized in that, The shape of the magnetic rod (11) is the same as the internal shape of the magnetic rod shell (13), and the magnetic rod (11) and the magnetic rod shell (13) are movably connected.

3. The magnetic bead-based nucleic acid extractor according to claim 1, wherein The upper surface of the support plate (2) is fixedly connected to the motor (4), which drives the lead screw (3) to rotate.

4. The magnetic bead-based nucleic acid extractor according to claim 1, wherein The upper surface of the support plate 2 (6) is fixedly connected to the motor 2 (8), which drives the lead screw 2 (7) to rotate.

5. The magnetic bead-based nucleic acid extractor according to claim 1, wherein The upper surface of the workbench (1) is fixedly connected to a fixing groove (14), and the front surface of the fixing groove (14) is rotatably connected to a fixing plate (15).

6. The magnetic bead-based nucleic acid extractor according to claim 1, wherein The magnetic rod plate (10) and the second support platform (9) are limited by a slot, and the magnetic rod plate (10) can be pulled out and replaced.

7. The magnetic bead-based nucleic acid extractor according to claim 1, wherein The magnetic rod sleeve (12) and the support platform (5) are fixed and limited by a slot, and the magnetic rod sleeve (12) can be pulled out and replaced.

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