Vancomycin sample rotating platform for mass spectrometry

Abstract

The utility model provides a vancomycin sample rotating platform for mass spectrum detection relates to rotating platform technical field, including fixed frame, still include buffer device, buffer device includes the sliding frame of fixed connection in fixed frame, slidingly connected with transmission block on the sliding frame, slidingly connected with sliding axle on transmission block, sliding axle is fixedly connected with swash plate through transmission link on, the utility model discloses rotating platform high -speed operation produces greater centrifugal force, and centrifugal force can make sample container have the tendency of throwing outwards. At this moment, transmission block drives horizontal pole, vertical rod movement, and the displacement of vertical rod is passed to the placing frame through the series link and universal joint, so that the placing frame drives the clamping frame reverse rotation. The torque generated by this reverse rotation is opposite to the direction of the torque formed by the centrifugal force, thereby achieving torque balance, solving the problem that the sample container will also produce uncontrollable displacement under the action of sudden vibration caused by other equipment in the existing laboratory environment in the background art.

Description

Technical Field

[0001] This utility model relates to the field of rotating stage technology, and in particular to a rotating stage for vancomycin samples for mass spectrometry detection. Background Technology

[0002] Vancomycin sample rotation stage is an auxiliary device that uses a 360-degree circular layout of sample positions and utilizes the centrifugal force generated by rotation to assist in the initial separation of sample components. At the same time, through high-precision rotation positioning, modular container compatible design, vibration-resistant structure and intelligent control technologies, it balances the negative impact of centrifugal force and realizes automatic sample positioning, dynamic sorting and information synchronization to meet the high-throughput and automated mass spectrometry detection needs of clinical batch vancomycin samples.

[0003] However, in existing technologies, when the stage rotation generates a large centrifugal force, the sample container may shift or shake due to uneven force. This shift cannot be corrected. The centrifugal force causes the sample liquid surface to tilt or even splash out, directly causing deviation in the injection volume. Under the periodic vibration generated by the high-frequency operation of the mass spectrometer, or the sudden vibration caused by other equipment in the laboratory environment, the sample container may also produce uncontrollable displacement, resulting in sample position deviation, which in turn causes fluctuations in the peak area response value of mass spectrometry detection, affecting the accuracy of vancomycin quantification results. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a vancomycin sample rotation stage for mass spectrometry detection.

[0005] To achieve the above objectives, this utility model adopts the following technical solution: a vancomycin sample rotation stage for mass spectrometry detection, comprising:

[0006] Fixture;

[0007] A buffer device includes a sliding frame fixedly connected to a fixed frame, a transmission block slidably connected to the sliding frame, a sliding shaft slidably connected to the transmission block, a swashplate fixedly connected to the sliding shaft via a transmission rod, a clamping frame fixedly connected to the swashplate, a fixed frame fixedly connected to the sliding frame, a slanted rod slidably connected to the fixed frame, a vertical rod slidably connected to the slanted rod, the vertical rod being fixedly connected to the swashplate, a vertical rod fixedly connected to the transmission block via a horizontal rod, a series rod slidably connected to the vertical rod, and a placement frame connected to the series rod.

[0008] In a preferred embodiment, a damper is fixedly connected to the transmission block, and the side of the damper away from the transmission block is fixedly connected to a fixed frame. A motor is fixedly connected inside the fixed frame, and the output end of the motor inside the fixed frame is fixedly connected to a diagonal rod. The placement frame and the clamping frame are fixedly connected.

[0009] The above technical solution is adopted: during use, the motor drives the swashplate to slide, so that the vertical rod repeatedly pushes the swashplate to move. The rubber transmission rod limits the swashplate and prevents it from deviating.

[0010] In a preferred embodiment, a spring is fixedly connected to the vertical rod, and the side of the spring away from the vertical rod is fixedly connected to the connecting rod.

[0011] The above technical solution allows for a more flexible connection between the vertical rod and the connecting rods during use by fixing a spring to the vertical rod.

[0012] In a preferred embodiment, a limiting frame is fixedly connected to the vertical rod, a limiting rod is fixedly connected to the limiting frame, and the limiting rod is slidably connected to the bottom of the swashplate.

[0013] The above technical solution is adopted: by fixing a limiting frame to the vertical rod, the limiting frame slides synchronously at the bottom of the swashplate when the vertical rod slides, so that the limiting frame drives the limiting rod to slide at the bottom of the swashplate.

[0014] In a preferred embodiment, a universal joint is fixedly connected to the connecting rod, and the side of the universal joint away from the connecting rod is fixedly connected to the bottom of the placement frame.

[0015] The above technical solution, by incorporating universal joints, makes the connection between the connecting rods and the placement frame more flexible.

[0016] In a preferred embodiment, a closed compartment is fixedly connected to the mounting frame.

[0017] The above technical solution is adopted: when in use, the closed compartment completely encloses the buffer device.

[0018] In a preferred embodiment, the transmission rod is slidably connected to the enclosed chamber.

[0019] The above technical solution is adopted so that the transmission rod is slidably connected to the inner wall of the closed chamber during use, so as to prevent the closed chamber from blocking the transmission rod.

[0020] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0021] This invention utilizes a motor-driven slant bar rotation, which in turn causes a vertical bar to slide at the bottom of the slant plate, resulting in regular swaying of the slant plate. Simultaneously, this triggers a transmission rod that drives a sliding shaft to slide within the slant groove of the transmission block, further pushing the transmission block inward to clamp the sample container. During this process, the transmission block's compression damping generates a counterforce, which can counteract the sample container displacement caused by centrifugal force during stage rotation. When the mass spectrometer experiences high-frequency vibration or external interference, causing displacement, the real-time swaying of the slant plate drives the transmission block to reciprocate with compression damping, forming a compensating force opposite to the vibration direction. When the rotating stage generates significant centrifugal force at high speed, the centrifugal force can cause the sample container to tend to be thrown outward. At this point, the transmission block drives the horizontal and vertical bars to move. The displacement of the vertical bar is transmitted to the placement frame through a connecting rod and a universal joint, causing the placement frame to rotate the clamping frame in the opposite direction. The torque generated by this reverse rotation is opposite to the torque generated by the centrifugal force, thus achieving torque balance. This solves the problem in the prior art where uncontrollable displacement of the sample container occurs under sudden vibrations caused by other equipment in the laboratory environment. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of a vancomycin sample rotation stage for mass spectrometry detection provided by this utility model.

[0023] Figure 2 This is a schematic diagram of the fixed frame position of a vancomycin sample rotation stage for mass spectrometry detection provided by this utility model.

[0024] Figure 3 This invention provides a schematic diagram of the damping position of a vancomycin sample rotation stage for mass spectrometry detection.

[0025] Figure 4 This is a schematic diagram showing the placement frame of a vancomycin sample rotation stage for mass spectrometry detection provided by this utility model.

[0026] Figure 5 This invention provides a schematic diagram of the swash plate position of a vancomycin sample rotating stage for mass spectrometry detection.

[0027] Figure 6 This invention provides a vancomycin sample rotation stage for mass spectrometry detection. Figure 5 Enlarged schematic diagram of the structure at point A in the middle.

[0028] Legend:

[0029] 1. Fixed frame; 11. Enclosed compartment;

[0030] 2. Buffer device; 21. Fixed frame; 22. Sliding frame; 23. Transmission block; 24. Damping; 25. Diagonal bar; 26. Vertical bar; 27. Clamping frame; 28. Transmission rod; 29. ​​Swashplate; 210. Sliding shaft; 211. Horizontal bar; 212. Vertical bar; 213. Spring; 214. Connecting rod; 215. Universal joint; 216. Placement frame;

[0031] 3. Limiting rod; 31. Limiting frame. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] like Figure 1-6 As shown, this utility model provides a technical solution: a vancomycin sample rotation stage for mass spectrometry detection, comprising:

[0034] Fixture 1;

[0035] The buffer device 2 includes a sliding frame 22 fixedly connected to the fixed frame 1, a transmission block 23 slidably connected to the sliding frame 22, a sliding shaft 210 slidably connected to the transmission block 23, a swashplate 29 fixedly connected to the sliding shaft 210 via a transmission rod 28, a clamping frame 27 fixedly connected to the swashplate 29, a fixed frame 21 fixedly connected to the sliding frame 22, a slidable rod 25 slidably connected to the fixed frame 21, a vertical rod 26 slidably connected to the swashplate 25, and a fixed connection between the vertical rod 26 and the swashplate 29. A vertical rod 212 is fixedly connected to the transmission block 23 via a horizontal rod 211, a series rod 214 slidably connected to the vertical rod 212, and a placement frame 216 connected to the series rod 214.

[0036] A damper 24 is fixedly connected to the transmission block 23. The side of the damper 24 away from the transmission block 23 is fixedly connected to the fixed frame 21. A motor is fixedly connected inside the fixed frame 21. The output end of the motor inside the fixed frame 21 is fixedly connected to the inclined rod 25. The placement frame 216 is fixedly connected to the clamping frame 27. When in use, the motor drives the inclined rod 25 to slide, which drives the vertical rod 26 to repeatedly push the swashplate 29 to move. The rubber transmission rod 28 restricts the offset of the swashplate 29 to ensure motion accuracy. At the same time, the transmission block 23 squeezes the damper 24 to generate a reverse buffer force, which effectively counteracts rotational vibration and ensures the stability of mass spectrometry detection.

[0037] In this utility model, when in use, the test tube is first fixed in the clamping frame 27 with bolts. By starting the motor, the inclined rod 25 is rotated, which causes the inclined rod 25 to drive the vertical rod 26 to slide, and the vertical rod 26 slides at the bottom of the inclined plate 29, causing the inclined plate 29 to bump.

[0038] During this process, the transmission rod 28 will follow the swashplate 29 and bounce. When the swashplate 29 drives the transmission rod 28 to slide down, the sliding shaft 210 will slide in the inclined groove on the transmission block 23, causing the transmission block 23 to be driven to slide inward. This causes the transmission block 23 to squeeze the damper 24 to offset part of the vibration force and prevent the vibration force transmitted to the fixed frame 1 from being too large. The probability of mutual interference when multiple machines are used at the same time is reduced.

[0039] Then, the transmission block 23 is activated, causing the horizontal bar 211 to move the vertical bar 212, which in turn causes the vertical bar 212 to rotate the placement frame 216, causing the clamping frame 27 to rotate in the opposite direction, thus offsetting part of the centrifugal force and preventing the centrifugal force from being too great and throwing the sample out of the container.

[0040] like Figures 2 to 6 As shown, a spring 213 is fixedly connected to the vertical rod 212. The side of the spring 213 away from the vertical rod 212 is fixedly connected to the connecting rod 214. The spring 213 provides elastic buffer for the connection between the vertical rod 212 and the connecting rod 214. When the platform rotates at high speed and generates centrifugal force, the spring 213 can adaptively adjust the connection angle and tension, effectively reducing the rigid impact between components, making the reverse rotation structure more responsive, and improving the centrifugal force balance efficiency.

[0041] like Figure 6 As shown, a limiting frame 31 is fixedly connected to the vertical rod 26, and a limiting rod 3 is fixedly connected to the limiting frame 31. The limiting rod 3 is slidably connected to the bottom of the swashplate 29. The limiting frame 31 and the limiting rod 3 form a double limiting structure. When the vertical rod 26 slides, the limiting rod 3 slides along the bottom of the swashplate 29, constraining the movement trajectory of the swashplate 29, preventing it from shifting laterally due to uneven force, ensuring the smooth operation of the swashplate 29, and maintaining the stability of the sample clamping.

[0042] like Figures 3 to 5 As shown, a universal joint 215 is fixedly connected to the connecting rod 214. The side of the universal joint 215 away from the connecting rod 214 is fixedly connected to the bottom of the placement frame 216. The universal joint 215 gives the connecting rod 214 and the placement frame 216 multi-dimensional rotational freedom. During the reverse rotation process to counteract the centrifugal force, the posture of the placement frame 216 can be flexibly adjusted to ensure that the clamping frame 27 always maintains the best balance angle, effectively improving the accuracy of centrifugal force compensation.

[0043] like Figures 1 to 4As shown, a closed chamber 11 is fixedly connected to the fixed frame 1. The closed chamber 11 completely seals the buffer device 2, isolating it from external sources of interference such as dust and vibration, while reducing the operating noise of the stage, creating a stable testing environment, reducing the impact of external factors on the sample testing results, and ensuring the long-term stable operation of the equipment.

[0044] like Figure 1 As shown, the transmission rod 28 is slidably connected to the enclosed chamber 11. The sliding fit between the transmission rod 28 and the inner wall of the enclosed chamber 11 avoids the enclosed chamber 11 from hindering the movement of the transmission rod 28, ensuring that the swashplate 29 runs smoothly under the push of the vertical rod 26. At the same time, it prevents hard friction between the transmission rod 28 and the enclosed chamber 11, extends the service life of the equipment, and improves the overall operational reliability.

[0045] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A vancomycin sample rotation stage for mass spectrometry detection, characterized in that, include: Fixture (1); A buffer device (2) includes a sliding frame (22) fixedly connected to a fixed frame (1), a transmission block (23) slidably connected to the sliding frame (22), a sliding shaft (210) slidably connected to the transmission block (23), a swashplate (29) fixedly connected to the sliding shaft (210) via a transmission rod (28), a clamping frame (27) fixedly connected to the swashplate (29), a fixed frame (21) fixedly connected to the sliding frame (22), a sloping rod (25) slidably connected to the fixed frame (21), a vertical rod (26) slidably connected to the sloping rod (25), the vertical rod (26) fixedly connected to the sloping plate (29), a vertical rod (212) fixedly connected to the transmission block (23) via a horizontal rod (211), a series rod (214) slidably connected to the vertical rod (212), and a placement frame (216) connected to the series rod (214).

2. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: A damper (24) is fixedly connected to the transmission block (23). The side of the damper (24) away from the transmission block (23) is fixedly connected to the fixed frame (21). A motor is fixedly connected inside the fixed frame (21). The output end of the motor inside the fixed frame (21) is fixedly connected to the inclined rod (25). The placement frame (216) is fixedly connected to the clamping frame (27).

3. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: A spring (213) is fixedly connected to the vertical rod (212), and the side of the spring (213) away from the vertical rod (212) is fixedly connected to the connecting rod (214).

4. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: A limiting frame (31) is fixedly connected to the vertical rod (26), and a limiting rod (3) is fixedly connected to the limiting frame (31). The limiting rod (3) is slidably connected to the bottom of the swashplate (29).

5. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: A universal joint (215) is fixedly connected to the connecting rod (214), and the side of the universal joint (215) away from the connecting rod (214) is fixedly connected to the bottom of the placement frame (216).

6. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: A closed compartment (11) is fixedly connected to the fixed frame (1).

7. The vancomycin sample rotation stage for mass spectrometry detection according to claim 1, characterized in that: The transmission rod (28) is slidably connected to the closed chamber (11).

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