A liquid medicine transfer device for interfacing with a multi-dose medicine vial

Abstract

The utility model provides a kind of with the butt joint of multi-dose medicine bottle liquid medicine transfer device, including medicine bottle attachment and puncture ware;Puncture ware includes the pedestal being set on medicine bottle attachment, and the pedestal is equipped with puncture needle and syringe connector;Puncture needle has first flow passage and second flow passage inside;The pedestal has pedestal air passage and pedestal liquid channel inside;Pedestal air passage is communicated first flow passage and pedestal outside, and air filter membrane is installed in pedestal air passage;Pedestal liquid channel is communicated syringe connector and second flow passage, and self-sealing valve is equipped in syringe connector;When needleless syringe is installed on syringe connector, self-sealing valve is forced to switch from closed state to open state;In this way, when liquid medicine transfer device is installed on multi-dose medicine bottle, and injection connector on it is not connected needleless syringe, self-sealing valve is automatically in closed state, to prevent external pollutants along syringe connector into multi-dose medicine bottle and pollute liquid medicine, improve the effective time of liquid medicine in multi-dose medicine bottle after opening.

Description

Technical Field

[0001] This utility model belongs to the field of medical device technology, specifically relating to a liquid transfer device that connects to a multi-dose medicine bottle. Background Technology

[0002] In the medical field, it is common to use a syringe with a needle to puncture a vial for aspiration and transfer of medication. However, the needle can easily become dull after puncturing the vial, which increases the pain experienced by the patient during injection. To solve this problem, a medication transfer device with a puncture function has been developed. When using it, simply puncture the vial stopper with the medication transfer device and connect it to the syringe to sterilely transfer the medication from the vial to the syringe.

[0003] Utility model patent application number 2023213357740 discloses a drug transfer device with air filtration, which includes a top cover, a base, a puncture needle, and a hollow connector. An air circulation cavity is formed in either the top cover or the base, and an air filter membrane is installed inside the cavity to divide it into a first half-cavity and a second half-cavity. The puncture needle has a first flow channel (i.e., a drug flow channel) communicating with the connector and a second flow channel (i.e., an air flow channel) communicating with the second half-cavity. The first half-cavity is connected to the outside of the drug transfer device via a third flow channel. This allows the air flow channel formed by the second and third flow channels to balance the pressure difference inside and outside the drug bottle without contaminating the drug, reducing the difficulty of drug aspiration.

[0004] However, the aforementioned drug transfer device is only suitable for single-dose vials (i.e., the vial contains only a fixed dose of drug solution required for a single administration). If used for multi-dose vials (i.e., containing the total dose of drug solution required for multiple administrations), the following problems will occur: After the drug transfer device punctures the stopper of the multi-dose vial and the needleless syringe is connected to the connector of the drug transfer device to draw the first dose of drug solution from the multi-dose vial, the needleless syringe will separate from the drug transfer device. At this time, the liquid channel formed by the hollow connector and the first flow channel will make the inside and outside of the multi-dose vial interconnected, which will lead to the remaining drug solution in the multi-dose vial facing risks such as chemical degradation, microbial growth, and reduced drug efficacy, significantly shortening the effective use period of the remaining drug solution.

[0005] Therefore, how to improve the drug transfer device to extend the effective shelf life of the drug solution in the opened multi-dose bottle after the drug transfer device punctures the multi-dose bottle is a technical problem that urgently needs to be solved in this field. Utility Model Content

[0006] In view of the shortcomings of the prior art, the purpose of this utility model is to provide a liquid transfer device that connects to multi-dose medicine bottles, which can seal the opened multi-dose medicine bottles to extend the sterility time of the liquid in the multi-dose medicine bottles, thereby increasing the effective period of the liquid after the multi-dose medicine bottles are opened.

[0007] To achieve the above and other related objectives, this utility model provides a drug transfer device for docking with multi-dose vials, including a vial attachment and a puncture device; the puncture device includes a base disposed on the vial attachment, a puncture needle at the bottom of the base, and a syringe connector for docking with a needleless injector on the base; the puncture needle has an axially extending first flow channel and a second flow channel; the base has a base air channel and a base liquid channel; the base air channel connects the first flow channel and the outside of the base, and an air filter membrane is installed inside the base air channel; the base liquid channel connects the syringe connector and the second flow channel. The syringe connector has a flow channel and a self-sealing valve. When the needleless syringe is installed on the syringe connector, the self-sealing valve is deformed by force to switch from the normal closed state to the fluid-connected state. Thus, when the drug transfer device is installed on the multi-dose vial and the syringe connector is not connected to the needleless syringe, the self-sealing valve in the syringe connector will automatically be closed to prevent external contaminants from entering the multi-dose vial through the inner cavity of the syringe connector and contaminating the drug solution, thereby increasing the effective time of the remaining drug solution in the multi-dose vial after opening. At the same time, the self-sealing valve in the closed state can also prevent the drug solution from leaking out.

[0008] Preferably, the self-sealing valve is an elastic column; the bottom of the elastic column is provided with a blind hole, and a normally sealed slit runs through the top surface of the blind hole and the top surface of the elastic column; thus, when the needleless injector is installed on the syringe connector, the needleless injector will squeeze the elastic column to deform the slit on it to form a liquid passage for the drug solution to pass through; after the needleless injector leaves the syringe connector, the slit will automatically return to a sealed state, which not only prevents the external environment from contaminating the drug solution, but also prevents leakage.

[0009] Preferably, the outer wall of the elastic column and / or the inner wall of the blind hole are provided with a plurality of annular grooves at intervals to improve the deformation capacity of the elastic column.

[0010] Preferably, the end of the base airway near the outside of the base and / or the syringe connector is provided with a removable cap structure to prevent leakage of fluid from the bottle when not drawing medication.

[0011] Preferably, the puncture needle is provided with an elastic sealing sleeve; the elastic sealing sleeve is configured to seal the puncture port of the multi-dose medicine bottle when the puncture needle punctures the bottle cap, so as to prevent outside air from communicating with the inside of the multi-dose medicine bottle through the gap between the puncture port and the puncture needle, thereby further reducing the probability of the medicine liquid in the multi-dose medicine bottle being contaminated and increasing the effective time of the remaining medicine liquid in the multi-dose medicine bottle after opening.

[0012] Preferably, the distance from the elastic sealing sleeve to the lower end of the puncture needle is less than the thickness of the bottle cap, so that the elastic sealing sleeve contacts the bottle cap before the puncture needle pierces the bottle cap. In this way, when the puncture needle continues to puncture the bottle cap, the elastic sealing sleeve will always be kept in contact with the bottle cap, so as to achieve continuous sealing of the puncture site on the bottle cap.

[0013] Preferably, the base airway is equipped with a one-way valve to prevent the protective gas in the multi-dose vial from escaping into the air.

[0014] Preferably, the base includes a horizontal base; a vial attachment vial connecting shell and a support plate formed above the vial connecting shell; the support plate has a through hole for the puncture needle to pass through, and a base connecting element for fixing the horizontal base is provided above the support plate; thus, the puncture device can be detachably assembled onto the vial attachment.

[0015] Preferably, the base connecting element includes multiple elastic buckles; when the horizontal base of the puncture device approaches the support plate axially from bottom to top, the horizontal base will push the multiple elastic buckles on the support plate to bend and deform outward. When the horizontal base passes the buckling part of the elastic buckle and contacts the support plate, each elastic buckle will return to its initial shape so as to use the buckling part to fasten the horizontal base to the support plate.

[0016] Preferably, a handheld device is provided above the horizontal base to facilitate the user's movement of the puncture device.

[0017] As described above, the liquid transfer device of this utility model that connects to multi-dose medicine bottles has the following beneficial effects:

[0018] This invention provides a self-sealing valve inside the injection connector of the drug transfer device. When the injection connector is not connected to a needleless syringe, the self-sealing valve, which is in a closed state, prevents external contaminants from entering the multi-dose vial through the inner cavity of the syringe connector and contaminating the drug solution, thereby increasing the effective time of the remaining drug solution in the multi-dose vial after opening.

[0019] When a multi-dose medicine bottle is filled with a protective gas such as nitrogen to achieve aseptic preservation of the medicine solution inside the bottle, a one-way valve can be added to the air channel of the base of the medicine transfer device to prevent nitrogen from leaking out of the multi-dose medicine bottle, thereby increasing the effective use time of the remaining medicine solution in the multi-dose medicine bottle after opening.

[0020] This invention features an elastic sealing sleeve fitted onto the puncture needle of a drug transfer device to seal the puncture opening of the bottle cap. This prevents the external environment from communicating with the interior of the multi-dose bottle through the gap between the puncture opening and the puncture needle, thereby further extending the effective time of the remaining drug solution in the multi-dose bottle after opening. Attached Figure Description

[0021] Figure 1A three-dimensional view of a drug transfer device installed on a multi-dose vial.

[0022] Figure 2 for Figure 1 Main cross-section view after removing the cap structure.

[0023] Figure 3 for Figure 2 Enlarged view of point A.

[0024] Figure 4 This is a three-dimensional exploded view of the drug transfer device.

[0025] Figure 5 This is a perspective view of a medicine bottle connecting shell in one embodiment.

[0026] Figure 6 for Figure 5 The image shows an isometric cross-sectional view of the medicine bottle connecting shell.

[0027] Figure 7 This is a main cross-sectional view of the syringe connector and the self-sealing valve assembled in one embodiment.

[0028] Figure 8 for Figure 7 The diagram shows the main cross-sectional view of the self-sealing valve.

[0029] Figure 9 This is a perspective view of the puncture device after it has been removed from the syringe connector in one embodiment.

[0030] Figure 10 for Figure 9 The diagram shows a main cross-sectional view of the puncture device after it reaches the syringe connector.

[0031] Explanation of reference numerals in the attached figures

[0032] Medicine bottle attachment 100, medicine bottle connecting shell 110, cover 111, upper shell 111a, transition shell 111b, lower shell 111c, clearance groove 112, elastic retainer 113, support plate 120, through hole 120a, elastic buckle 130, puncture device 200, base 210, horizontal base 211, first fluid cavity 211a, second fluid cavity 211b, liquid passage tube 212, liquid passage channel 212a, first handheld part 213a, second handheld part 213b, puncture needle 220, first flow channel 220a, second flow channel 220b, syringe connector 230. Valve mounting cavity 230a, valve seat 231, first connector 232, limiting step 2321, second connector 233, conical tube 2331, threaded cylinder 2332, elastic column 240, slit 240a, blind hole 240b, annular groove 240c, sealing part 241, limiting part 242, deformable part 243, vent connector 250, one-way valve 251, air filter membrane 261, liquid filter membrane 262, cap structure 300, elastic sealing sleeve 400, multi-dose medicine bottle 500, bottle body 510, bottle neck 511, bottle mouth 513, bottle cap 520. Detailed Implementation

[0033] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification.

[0034] Please see Figures 1 to 10 It should be understood that the structures, proportions, sizes, etc., illustrated in the accompanying drawings are merely for illustrative purposes to aid those skilled in the art and are not intended to limit the scope of this invention. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and purpose of this invention, should still fall within the scope of the disclosed technical content. Furthermore, the terms "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and not intended to limit the scope of this invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of this invention.

[0035] like Figures 1 to 3 As shown, this embodiment provides a drug transfer device that docks with a multi-dose vial 500. The drug transfer device includes a vial attachment 100 and a puncture device 200.

[0036] The vial attachment 100 is used to attach the multi-dose vial 500 to achieve relative fixation between the two; while the multi-dose vial 500 contains the total dose of medicine required for multiple administrations.

[0037] The puncture device 200 includes a base 210 disposed on a vial attachment 100, the bottom of which is provided with a puncture needle 220 for piercing the cap of a multi-dose vial 500, and the base 210 is provided with a syringe connector 230 for docking with a needleless injector.

[0038] Specifically, such as Figure 2 and Figure 3 As shown, the puncture needle 220 has an axially extending first flow channel 220a and a second flow channel 220b, which are separated within the puncture needle 220. The base 210 has a base air passage and a base liquid passage. The base air passage connects the first flow channel 220a to the outside of the base, and an air filter membrane 261 is installed inside the base air passage to filter the outside air entering the base air passage, thereby preventing contamination from harmful substances such as particles, bacteria, and viruses in the air. The multi-dose vial 500 contains liquid medication; meanwhile, the air filter membrane 261 has hydrophobic properties, allowing only gas to pass through and not liquid to pass through, thereby effectively preventing the liquid medication in the multi-dose vial 500 from leaking into the external environment; the base liquid channel is used to connect the syringe connector 230 and the second flow channel 220b, and the syringe connector 230 is equipped with a self-sealing valve; when the needleless syringe (not shown in the figure) is installed on the syringe connector 230, the self-sealing valve will deform under force to switch from the normal closed state to the fluid connected state.

[0039] Thus, when the medication transfer device is installed on the multi-dose vial 500 and the injection connector 230 on the medication transfer device is not connected to the needleless injector, the self-sealing valve inside the syringe connector 230 will automatically be closed. This not only prevents external contaminants (such as dust, bacteria, and other harmful substances) from entering the multi-dose vial 500 through the inner cavity of the syringe connector 230 and contaminating the medication, ensuring the effective time of the remaining medication in the multi-dose vial 500 after opening, but also prevents medication leakage and avoids medication waste. When the needleless injector is connected to the syringe connector 230, the needleless injector will squeeze the self-sealing valve inside the syringe connector 230, causing the self-sealing valve to deform under force and enter a fluid-connected state, thus connecting the multi-dose vial 500 with the needleless injector and realizing the transfer of medication between the multi-dose vial 500 and the needleless injector.

[0040] It should be noted that the multi-dose vial 500 contains either liquid medicine or lyophilized powder before opening, and there are no restrictions on this; however, if the multi-dose vial 500 contains lyophilized powder before opening, such as... Figure 2As shown, the multi-dose vial 500 can be attached to the vial attachment 100 of the drug transfer device first, and the puncture needle 220 can pierce the vial cap 520 to penetrate the inside of the multi-dose vial 500. Then, the needleless injector containing the sustained-release drug solution is connected to the injector connector 230 of the drug transfer device, and the sustained-release drug solution in the needleless injector is injected into the multi-dose vial 500 to dissolve the lyophilized powder in the vial and obtain the desired drug solution. During the injection of the sustained-release drug solution into the multi-dose vial 500, the gas inside the vial will be discharged to the external environment along the first flow channel 220a and the base air channel to ensure the balance of the gas pressure inside and outside the vial, thereby avoiding the problem of the drug solution spraying out due to excessively high gas pressure inside the vial. When the needleless injector draws the drug solution from the multi-dose vial 500, the external air will enter the multi-dose vial 500 along the base air channel and the first flow channel 220a to ensure the balance of the gas pressure inside and outside the vial, thereby reducing the difficulty of aspiration.

[0041] It should be noted that the needle-free injector is a disposable item. After being connected to the liquid transfer device attached to the multi-dose vial 500, it will only draw a single dose of liquid from the multi-dose vial 500. The needle-free injector that draws a single dose of liquid will be separated from the liquid transfer device for subsequent injection. The self-sealing valve in the liquid transfer device will automatically return to its normal closed state due to the separation of the needle-free injector to protect the remaining liquid in the multi-dose vial 500.

[0042] It should be noted that the air filter membrane 261 is existing technology, which is made of hydrophobic filter materials such as polytetrafluoroethylene (PTFE).

[0043] In a preferred embodiment, such as Figure 2 As shown, a drug solution filter membrane 262 is provided in the liquid channel of the base to filter out impurities such as glue debris in the drug solution, so as to prevent them from being drawn into the needleless injector along with the drug solution.

[0044] It should be noted that the liquid filter membrane 262 is existing technology, and it is made of liquid filter materials such as polypropylene.

[0045] like Figure 7 and Figure 8As shown, the inner cavity of the syringe connector 230 includes a valve mounting cavity 230a, and the self-sealing valve includes an elastic column 240 that is sealed and filled in the valve mounting cavity 230a; the bottom of the elastic column 240 is provided with a blind hole 240b, and a normally sealed slit 240a runs through between the top surface of the blind hole 240b and the top surface of the elastic column 240; thus, when the needleless syringe is installed on the syringe connector 230, the needleless syringe will squeeze the elastic column 240 to deform the slit 240a on it to form a liquid passage for the liquid to pass through; after the needleless syringe leaves the syringe connector 230, the slit 240a will automatically return to a sealed state due to the disappearance of external force, thereby preventing the external environment from contaminating the liquid and playing a role in preventing leakage.

[0046] It should be noted that the material of the elastic column 240 is any existing elastic material such as rubber or silicone, and there is no limitation on it.

[0047] In a preferred embodiment, such as Figure 8 As shown, the outer wall of the elastic column 240 is provided with a plurality of annular grooves 240c at intervals, and / or the wall of the blind hole 240b is provided with a plurality of annular grooves 240c at intervals; the setting of the annular grooves 240c can partially thin the elastic column 240 to improve the elastic deformation capacity of the elastic column 240.

[0048] In a further embodiment, such as Figure 7 As shown, the elastic column 240 includes a sealing part 241 and a deformable part 243 with a hollow cavity. A slit 240a is formed on the sealing part 241. The deformable part 243 is located below the sealing part 241, and the bottom end of the deformable part 243 is fixed to the bottom of the valve mounting cavity 230a by means of adhesive, snap-fit, etc. At this time, an annular groove 240c is provided on the deformable part 243 to improve the elastic deformation capability of the deformable part 243.

[0049] In a further embodiment, such as Figure 7 As shown, the valve mounting cavity 230a has a limiting step 2321, and the sealing part 241 and the deformation part 243 are connected by a limiting part 242 that cooperates with the limiting step 2321; through the cooperation of the limiting step 2321 and the limiting part 242, the initial position of the sealing part 241 (i.e., the position when it is not subjected to external force) is limited, so as to prevent the sealing part 241 from protruding out of the valve mounting cavity 230a.

[0050] Of course, in other embodiments, the self-sealing valve may also adopt a sealing structure that can achieve normal closure and fluid communication when squeezed, as disclosed in patents such as CN2019205072983, and there is no limitation on this.

[0051] In addition, to facilitate the installation of self-sealing valves, such as Figure 7As shown, the syringe connector 230 includes a valve seat 231 and a first connector 232 for connecting a needleless syringe; wherein, the lower end of the first connector 232 is sealed and fitted onto the valve seat 231, and the hollow inner cavity of the valve seat 231 communicates with the hollow inner cavity of the first connector 232 to form a valve mounting cavity 230a.

[0052] It should be noted that the valve seat 231 of the syringe connector 230 can be directly formed on the base 210 or detachably installed on the base 210, and there is no limitation on this; in this embodiment, the valve seat 231 is preferably detachably installed on the base 210.

[0053] Specifically, such as Figure 2 , Figure 9 and Figure 10 As shown, the base 210 includes a horizontal base 211 and a liquid passage 212 that connects to the valve seat 231; wherein, the liquid passage 212 is located above the horizontal base 211, and the liquid passage channel within the liquid passage 212 is connected to the second flow channel 220b within the puncture needle 220; at this time, as Figure 7 and Figure 9 As shown, a second connector 233 is connected to the lower part of the valve seat 231, and a third connector is formed on the liquid passage 212 to mate with the second connector 233. Through the cooperation of the second connector 233 and the third connector, the syringe connector 230 and the base 210 are sealed and installed.

[0054] In this embodiment, the third connector is a Luer female connector with a tapered inner cavity, and the second connector 233 is a Luer male connector that mates with the Luer female connector; the structure of the second connector 233 is as follows. Figure 7 As shown, it includes a tapered insertion tube 2331 and a threaded sleeve 2332 coaxially disposed on the tapered insertion tube 2331. The threaded sleeve 2332 is used for threaded connection with the third connector. Thus, when the threaded sleeve 2332 of the second connector 233 is screwed onto the third connector, the tapered insertion tube 2331 will be sealed and inserted into the tapered inner cavity of the third connector, thereby achieving a sealed installation of the second connector 233 and the third connector.

[0055] Of course, the positions of the second connector 233 and the third connector can be interchanged, or other medical connectors that can achieve leak-free connection can be used; there are no restrictions on this.

[0056] For ease of gripping, the base 210 also includes a handheld component located above the horizontal base 211; such as Figure 9 and Figure 10As shown, the handheld device includes a first handheld device 213a located on one side of the liquid passage 212, and the first handheld device 213a is provided with a vent connector 250 communicating with the first flow channel 220a; wherein, the inner cavity of the vent connector 250 is part of the base air passage; at this time, a one-way valve 251 can be added inside the vent connector 250 to prevent the protective gas in the multi-dose medicine bottle 500 from leaking out through the vent connector 250.

[0057] Since the one-way valve 251 is existing technology, it will not be described in detail. For its specific structure, please refer to the one-way valve structure disclosed in patents such as CN2014100725754.

[0058] Furthermore, such as Figure 9 and Figure 10 As shown, the handheld device also includes a second handheld device 213b located on the other side of the liquid pipe 212; the first handheld device 213a and the second handheld device 213b are located in the same vertical plane. Both the first handheld device 213a and the second handheld device 213b are plate-shaped structures with anti-slip parts to facilitate the user's grip.

[0059] In addition, such as Figure 9 and Figure 10 As shown, the horizontal substrate 211 has a first cavity 211a and a second cavity 211b that are isolated from each other; wherein, the first cavity 211a is used to connect the inner cavity of the first flow channel 220a and the vent connector 250; the second flow channel 220b is used to connect the liquid channel 212a and the second flow channel 220b; the air filter membrane 261 is disposed in the first cavity 211a, and the medicine filter membrane 262 is disposed in the second cavity 211b.

[0060] It should be noted that the horizontal substrate 211 includes an upper substrate and a lower substrate. The puncture needle 220 is formed on the lower substrate, and the connecting tube 212 and the handpiece are formed on the upper substrate. The upper substrate and the lower substrate are joined together to form an independent first cavity 211a and a second cavity 211b. The joint between the two is ultrasonically welded together to ensure the independence of the first cavity 211a and the second cavity 211b.

[0061] In addition, such as Figure 4 As shown, the medicine bottle attachment 100 includes a medicine bottle connecting shell 110. The medicine bottle connecting shell 110 can be directly formed on the lower base of the horizontal base 211, or it can be detachably installed on the horizontal base 211. There is no limitation on this. In this embodiment, the medicine bottle connecting shell 110 is preferably detachably installed on the horizontal base 211.

[0062] Since the structure of the vial connecting shell 110 is closely related to the specific structure of the multi-dose vial 500, in this application, the multi-dose vial 500 is preferably a vial or vial-like structure, which includes a vial body 510 and a vial cap 520; the vial body 510 includes a vial body 511, a neck 512, and a vial mouth 513 connected sequentially from bottom to top, the outer diameter of the neck 512 is smaller than the outer diameter of the vial body 511 and the vial mouth 513, so that an annular groove can be formed between the vial body 511 and the vial mouth 513; the vial cap 520 is a rubber stopper or a rubber stopper with a central hole aluminum cap, and the rubber stopper of the vial cap 520 is sealed at the vial mouth 513 of the vial 500. At this time, the vial cap 520 and the vial mouth 513 together constitute the head of the multi-dose vial 500.

[0063] At this time, as Figures 4 to 6 As shown, the vial connecting shell 100 includes a cover 110 for covering part or all of the multi-dose vial 500 and a plurality of elastic retaining members 113 evenly arranged around the center line of the cover. When the multi-dose vial 500 is inserted into the shell 110 of the vial connecting shell 100, each elastic retaining member 113 bends and deforms outward under the pressure of the multi-dose vial 500. When the multi-dose vial 500 is inserted into place, each elastic retaining member 113 will automatically reset to form an anti-detachment component that abuts against the bottom or head of the multi-dose vial 500 to prevent the multi-dose vial 500 from detaching from the vial connecting shell 100 and ensure the stability of the connection between the two.

[0064] In a preferred embodiment, such as Figure 5 As shown, the housing 111 includes an upper housing 111a, a transition housing 111b, and a lower housing 111c, which are coaxially connected from top to bottom. The inner diameter of the upper housing 111a matches the outer diameter of the head of the multi-dose vial 500, and the inner diameter of the lower housing 111c matches the outer diameter of the body of the multi-dose vial 500, thereby effectively preventing the multi-dose vial 500 attached to the vial connecting shell 110 from deflecting.

[0065] In an alternative embodiment, such as Figure 5 As shown, the outer wall of the cover 111 is provided with a relief groove 112 corresponding to the elastic retainer 113, and the bottom or top of the relief groove 112 is connected to one end of the corresponding elastic retainer 113; at this time, the free end of the elastic retainer 113 is a stop part that abuts against the bottom or the bottom of the head of the multi-dose medicine bottle 500.

[0066] Understandably, when the lower end of the elastic retainer 113 is a free end, the lower housing 111c and the transition housing 111b can be eliminated. Of course, the lower part of the clearance groove 112 can also extend to the bottom of the upper housing 111a to form an open structure.

[0067] Of course, in other embodiments, if the head of the multi-dose vial 500 has an external thread structure, the vial connecting shell 110 can also be directly threaded onto the multi-dose vial 500.

[0068] To achieve a detachable connection between the medicine bottle connecting shell 110 and the horizontal base 211, such as Figure 4 As shown, a support plate 120 is formed on the upper part of the medicine bottle connecting shell 110. The support plate 120 is provided with a through hole 120a for the puncture needle 220 to pass through, and a base connecting element for connecting the horizontal base 211 is provided on the upper part of the support plate 120.

[0069] It is understood that the base connecting element can be connected to the horizontal base 211 by a detachable method such as a snap-fit ​​or threaded connection, and there is no limitation thereto; in this embodiment, the base connecting element is preferably connected to the horizontal base 211 by a snap-fit ​​method.

[0070] Specifically, such as Figure 4 As shown, the base connecting element includes multiple elastic buckles 130, each elastic buckle 130 including an elastic arm and a buckling portion located at the free end of the elastic arm; when the horizontal base 211 of the puncture device 200 approaches the support plate 120 axially from bottom to top, the horizontal base 211 will push the multiple elastic buckles 130 on the support plate 120 to bend and deform outward; when the horizontal base 211 passes the buckling portion of the elastic buckle 130 and contacts the support plate 120, each elastic buckle 130 will return to its initial shape to fasten the horizontal base 211 to the support plate 130 using the buckling portion.

[0071] In a preferred embodiment, such as Figure 2 and Figure 3 As shown, the puncture needle 220 is provided with an elastic sealing sleeve 400; the elastic sealing sleeve 400 is configured to seal the puncture opening of the bottle cap 520 when the puncture needle 220 punctures the bottle cap 520, so as to prevent the liquid medicine in the bottle from leaking out along the gap between the puncture opening and the puncture needle 220.

[0072] It should be noted that the elastic sealing sleeve 400 is made of elastic materials such as rubber and silicone, and there are no restrictions on this.

[0073] In a further embodiment, in the initial state, the distance from the elastic sealing sleeve 400 to the lower end of the puncture needle is less than the thickness of the rubber stopper of the bottle cap 520, and there is a preset distance between the elastic sealing sleeve 400 and the upper support plate 120 (or, when there is no support plate 120, a horizontal base 211). The preset distance is determined according to the actual situation, as long as the elastic sealing sleeve 400 is in a compressed state when the multi-dose medicine bottle 500 is attached to the medicine transfer device; thus, when the multi-dose medicine bottle 500 is inserted into the medicine bottle connecting shell 110, The cap 520 is gradually pierced by the puncture needle 220. Before the cap 520 is completely pierced, the top of the cap 520 will contact the elastic sealing sleeve 400. At this time, the multi-dose vial 500 continues to be inserted, and the elastic sealing sleeve 400 will move with the vial towards the support plate 120 until the multi-dose vial 500 is inserted in place. During this process, the elastic sealing sleeve 400 is always in contact with the cap 520 to achieve continuous sealing of the puncture site during the puncture process, thereby preventing the protective gas in the vial from leaking out during the puncture.

[0074] In addition, such as Figure 1 As shown, the vent connector 250 and / or syringe connector 230 are provided with a removable cap structure 300 for protection and sealing.

[0075] In summary, this invention incorporates a self-sealing valve within the injection connector 230 of the drug transfer device. When the injection connector 230 is not connected to a needleless injector, the closed self-sealing valve prevents external contaminants from entering the multi-dose vial and contaminating the drug solution through the inner cavity of the connector 230, thereby extending the effective time of the remaining drug solution in the multi-dose vial after opening. Furthermore, the elastic sealing sleeve 400 fitted onto the puncture needle 220 seals the puncture opening of the vial cap 400, preventing external environmental factors from communicating with the interior of the multi-dose vial 500 through the gap between the puncture opening and the puncture needle 400, further extending the effective time of the remaining drug solution in the multi-dose vial 500 after opening.

[0076] In summary, this utility model effectively overcomes the various shortcomings of the prior art and has high industrial application value.

[0077] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.

Claims

1. A drug transfer device that interfaces with multi-dose vials, characterized in that, The device includes a vial attachment (100) and a puncture device (200); the puncture device (200) includes a base (210) disposed on the vial attachment (100), the bottom of the base (210) being provided with a puncture needle (220), and the base (210) being provided with a syringe connector (230) for docking with a needleless injector; the puncture needle (220) has an axially extending first flow channel (220a) and a second flow channel (220b); the base (210)... 0) It has a base air passage and a base liquid passage; the base air passage is used to connect the first flow channel (220a) and the outside of the base, and an air filter membrane is installed in the base air passage; the base liquid passage is used to connect the syringe connector (230) and the second flow channel (220b), and a self-sealing valve is provided in the syringe connector (230); when the needleless syringe is installed on the syringe connector (230), the self-sealing valve is deformed by force and switches from the normal closed state to the fluid connected state.

2. The drug transfer device according to claim 1, characterized in that, The self-sealing valve includes an elastic column (240); the bottom of the elastic column (240) is provided with a blind hole (240b), and a normally sealed slit (240a) runs through the top surface of the blind hole (240b) and the top surface of the elastic column (240).

3. The drug transfer device according to claim 2, characterized in that, The outer wall of the elastic column (240) and / or the inner wall of the blind hole (240b) are provided with a plurality of annular grooves (240c) spaced apart.

4. The drug transfer device according to any one of claims 1 to 3, characterized in that, The base airway is provided with a removable cap structure (300) at one end near the outside of the base and / or on the syringe connector (230).

5. The drug transfer device according to any one of claims 1 to 3, characterized in that, The puncture needle (220) is provided with an elastic sealing sleeve (400); the elastic sealing sleeve (400) is configured to seal the puncture site of the cap (520) when the puncture needle (220) punctures the cap (520) of the multi-dose vial (500).

6. The drug transfer device according to claim 5, characterized in that, The distance from the elastic sealing sleeve (400) to the lower end of the puncture needle is less than the thickness of the bottle cap (520).

7. The drug transfer device according to any one of claims 1 to 3, characterized in that, The base air passage is equipped with a one-way valve (251).

8. The drug transfer device according to any one of claims 1 to 3, characterized in that, The base (210) includes a horizontal base (211); the vial attachment (100) includes a vial connecting shell (110) and a support plate (120) formed above the vial connecting shell (110); the support plate (120) is provided with a through hole (120a) for the puncture needle to pass through, and a base connecting element for fixing the horizontal base (211) is provided above the support plate (120).

9. The drug transfer device according to claim 8, characterized in that, The substrate connecting element includes multiple elastic clips (130).

10. The drug transfer device according to claim 9, characterized in that, A handheld device is provided above the horizontal base (211).

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