Fusion protein that specifically binds to the extradomain b of fibronectin (edb-fn) and transforming growth factor β (tgf-β), and use thereof

Abstract

The present invention relates to a fusion protein that specifically binds to the extradomain B of fibronectin (EDB-FN) and transforming growth factor β (TGF-β), and use thereof; and, more specifically, to a fusion protein comprising a polypeptide that specifically binds to EDB-FN and a polypeptide that specifically binds to TGF-β, and use thereof.The fusion protein according to the present invention fixes TGF-β, which plays an important role in antitumor immune responses, to the extracellular matrix, in order to localize the inhibition of TGF-β directly in the tumor microenvironment and ensure a local rather than systemic effect, thus showing an excellent anticancer effect in all carcinomas, including pancreatic cancer, in which the usual TGF-β inhibitors do not act due to the rigidity of the extracellular matrix, so that it can be used effectively for the prevention or treatment of cancer.