COMPUTER SYSTEM FOR SETTING VALUES OF A BLOOD TREATMENT DEVICE

Description

[0001] The present invention relates to a computer system according to the preamble of claim 1. It further relates to a blood treatment device according to the preamble of claim 8 and a system according to the preamble of claim 10. It further relates to a method according to the preamble of claim 11, a digital storage medium according to claim 13, and a computer program product according to claim 14. For the purpose of blood treatment, settings for variable treatment parameters are to be entered into the blood treatment device used for this purpose by a user, e.g., clinical staff. The user can change such settings by means of manual input, e.g., on a screen (touchscreen) or at other interfaces.

[0002] To achieve predetermined treatment goals or specifications, such as the renal dose in dialysis treatment, it may be necessary for the user to determine or change a number of setting values, some of which interact with each other, which is why setting up the blood treatment device can be a demanding and error-prone activity.

[0003] Patent application EP 2 762 179 A2, as the closest prior art, discloses a device for the extracorporeal treatment of blood with a control unit configured to calculate values ​​for two or more fluid flow rates based on a fluid flow rate set by the operator and a prescribed dosage value.

[0004] An object of the present invention may be to propose a computer system for assisting the user in setting parameters of a blood treatment device, as well as a blood treatment device comprising a computer system according to the invention, a system, and a method. Furthermore, a digital storage medium, a computer program product, and a computer program are to be proposed.

[0005] The problem according to the invention can be solved by a computer system with the features of claim 1. It can further be solved by a blood treatment device with the features of claim 8, by a system with the features of claim 10, and by a method with the features of claim 11. It can also be solved by a digital storage medium with the features of claim 13 and by a computer program product with the features of claim 14.

[0006] The computer system according to the invention serves a user (doctor, staff, etc.) to define settings for later use on a blood treatment device and thus supports the user. It has at least a first input interface, a second input interface, and an output interface. Furthermore, it has a computing device and a display device or is connected to the aforementioned interfaces via signal transmission.

[0007] The computing device is programmed to read in a target value, which can also be a target range, here exemplified as the renal dose, as a parameter value for a treatment of a patient using a blood treatment device, especially a later or future one.

[0008] Furthermore, the computing device is programmed to display a selection range calculated by the computing device to a user by means of the display device, preferably in a graphic.

[0009] The selection range is determined by the computing device taking into account the input target value for the renal dose. For example, the selection range can display a multitude of combinations with exactly one setting value for the blood pump flow on the one hand and exactly one setting value for the dialysis fluid pump flow on the other. These setting ranges, if configured on the blood treatment device, allow (ceteris paribus) the target value to be achieved based on the information available to the computing device.

[0010] A second input interface allows the user to select one, preferably any, of the displayed combinations.

[0011] The computing device is further programmed to output the setting value for the blood pump and the setting value for the dialysis fluid pump of the selected combination via the output interface.

[0012] The blood treatment device according to the invention is designed as a dialysis device which has a computer system according to the invention.

[0013] The system according to the invention comprises or consists of one or more blood treatment devices and a computer system according to the invention.

[0014] The blood treatment device is preferably designed as a dialysis device.

[0015] The one or more blood treatment devices and the computer system are separate from each other. The term "separate from each other" can, for example, include spatial or physical separation and / or separation such that no signal communication exists between the blood treatment device and the computer system.

[0016] The inventive method for determining the setting values ​​of a blood treatment device (or for assisting, for example, medical personnel in finding or determining suitable setting values) comprises the following steps: a. Providing a computer system, a blood treatment device, or a system according to the invention; b. Reading in a target value and / or a target range for a parameter value for a treatment of a patient, preferably following completion of the method according to the invention, for example, for the renal dose, by means of a blood treatment device, or entering this parameter value by means of a first input interface; the first input interface can optionally be used as a read interface; c. Displaying a selection range of combinations of setting values ​​calculated or determined by the computing device, wherein the display is carried out by means of the display device, for example, in a graphic, e.g., in a diagram; d. Selecting one of the combinations displayed by means of the selection range by the user by means of a second input interface; and e.Output of the setting values ​​for the blood pump and the dialysis fluid pump of the selected combination via the output interface.

[0017] Everything stated above or below regarding the computer system according to the invention or its features applies analogously without limitation to the method according to the invention or its possible embodiments, and vice versa. Therefore, to avoid repetition, reference is made here to explanations and definitions concerning the same subject matter or concept that are given elsewhere herein.

[0018] A digital storage medium according to the invention, in particular non-volatile, in particular in the form of a machine-readable carrier, in particular in the form of a floppy disk, CD, DVD, EPROM, FRAM (ferroelectric RAM) or SSD (solid-state drive), in particular with electronically or optically readable control signals, can be configured or programmed to interact with a programmable computer system in such a way that a computer system is reprogrammed into a computer system according to the invention, e.g. when its memory content is executed on the programmable computer system.

[0019] A computer program product according to the invention comprises volatile, transient, or machine-readable program code or a signal wave, configured to interact with a programmable computer configuration of a computer system in such a way that the computer system is reprogrammed into a computer system according to the invention. According to the invention, a computer program product can be, for example, a computer program stored on a medium, an embedded system as a comprehensive system with a computer program (e.g., an electronic device with a computer program), a network of computer-implemented computer programs (e.g., a client / server system, a cloud computing system, etc.), or a computer on which a computer program is loaded, running, stored, executed, or being developed.

[0020] The term "machine-readable medium," as used herein, refers in certain embodiments of the present invention to a medium containing data or information that can be interpreted by software and / or hardware. The medium may be a data carrier such as a floppy disk, CD, DVD, USB flash drive, flash card, SD card, and the like, as well as any other storage device or storage medium mentioned herein.

[0021] According to the invention, a computer program product can also be understood to be a programmed application (abbreviated: app), for example in particular for a smartphone, a tablet or other mobile handheld device.

[0022] A computer program according to the invention comprises program code for causing a computer system to be reprogrammed into a computer system according to the invention when the computer program runs on a corresponding computer system. According to the invention, a computer program can be understood, for example, as a physical, marketable software product that comprises a program.

[0023] In all preceding and following explanations, the use of the expression "may be" or "may have" etc. is to be understood as synonymous with "is preferably" or "has preferably" etc. and is intended to explain embodiments according to the invention.

[0024] Embodiments according to the invention may have one or more of the features mentioned above or below.

[0025] Further embodiments according to the invention are the subject of the dependent claims.

[0026] Whenever numerical terms are mentioned herein, the expert understands them to indicate a lower numerical limit.

[0027] Provided this does not lead to any contradiction apparent to a person skilled in the art, a person skilled in the art will therefore always interpret the expression "ein" or "einem" as meaning "at least one" or "at least one". This understanding is encompassed by the present invention, as is the interpretation that a numerical word such as "ein" can alternatively be meant as "exactly one", wherever this is technically feasible to a person skilled in the art. Both are encompassed by the present invention and apply to all numerical words used herein.

[0028] Whenever a suitability or a process step is mentioned herein, the present invention preferably also includes corresponding programming or configuration of a suitable, in particular according to the invention, device or a section thereof.

[0029] Whenever an embodiment is mentioned herein, it refers to an exemplary embodiment according to the invention.

[0030] In case of doubt by a person skilled in the art, the terms "top" and "bottom" are to be understood as absolute or relative spatial references relating to the orientation of the component in question during its normal use.

[0031] If it is disclosed herein that the object of the invention has one or more features in a particular embodiment, it is also disclosed herein that the object of the invention expressly does not have precisely this or these features in other embodiments, which are also according to the invention, e.g., in the sense of a disclaimer. For each embodiment mentioned herein, the opposite embodiment, formulated, for example, as a negation, is therefore also disclosed.

[0032] The selection range may include fewer combinations than are technically possible and / or shown in the graphic.

[0033] Selecting combinations displayed in the selection area can also involve highlighting, for example, using a computer mouse. Optionally, this selection can include moving an already highlighted value or combination to a new value or combination.

[0034] The first and / or second input interface can each be a suitably designed touchscreen, a rotary switch, a slider, a keyboard or the like.

[0035] The first and second input interfaces can be identical, meaning they can be implemented through a single, shared input interface. Alternatively, they can be different and / or independent of each other.

[0036] Considering the target value or range when determining or calculating the settings of the selection range can be done, for example, based on known algorithms, which in turn can incorporate further parameter values, e.g., from auxiliary tables, etc. These algorithms and / or further parameter values ​​(as well as related further settings) can, for example, be stored in a memory device of the computer system.

[0037] The target value can be entered by the user or read from the computing device via its first interface, which may be, for example, an interface to a storage device.

[0038] The target value can refer to the specific patient being treated.

[0039] A renal dose can be determined as the quotient of effluent flow or filtrate flow on the one hand and patient weight on the other.

[0040] When determining the effluent flow rate, various flows (e.g., dialysate flow rate, substitution flow rate, calcium flow rate, citrate flow rate, net ultrafiltration) may need to be considered, depending on the type of therapy.

[0041] The renal dose can, for example, be the renal target dose ( TRD ) or the effective renal dose ( RRD ) be.

[0042] The renal target dose ( TRD ) can be calculated, for example, using the following formula: TRD = PostDF + DF + NFRF + PreDF 1 + PreDF BF m The following applies:

[0043] BF Blood flow rate RF Dialysis fluid flow rate NFRF Net liquid withdrawal flow rate m Patient weight PostDF Post-dilution flow rate PreDF Pre-dilution flow rate.

[0044] The effective renal dose ( RRD ) may vary depending on the duration of therapy t using the formula RRD = PostDV t + DV t + NFRV t + PreDV t 1 + PreDV t BV t m calculated, whereby the following applies: BV processed blood volume DV Dialysis fluid volume NFRV Net fluid removal volume m Patient weight PostDV Post-dilution volume PreDV Pre-dilution volume

[0045] In some embodiments, the computing device of the computer system is programmed to read in further parameter values, e.g., of the same or a different parameter, and to further restrict, segment, subdivide, or classify the selection range of possible settings based on these parameter values. Reading in these further parameter values ​​can be done in the same way as reading in the target value.

[0046] In some embodiments, the additional parameters or parameter values ​​take into account or relate to anticoagulation targeted for or during treatment, in particular citrate-calcium anticoagulation, or to a target bicarbonate concentration, e.g. in serum.

[0047] In some embodiments, the computer system is or includes a mobile device. It may be or include a handheld device, mobile phone, smartphone, tablet, or the like.

[0048] In some embodiments, the computer system includes a computer program or application (in short: app) that can be loaded onto, stored on, executed, or run on such a mobile device or other device.

[0049] In some embodiments, the computer system's computing device is programmed to display the settings for the blood pump and the dialysis fluid pump of the selected combination to the user via the display device and / or to output them via the output interface, e.g., to a control or regulating device of a blood treatment device. This device can then read and / or store the transmitted settings.

[0050] The transmitted settings can be used by the blood treatment device for an upcoming treatment session.

[0051] In some embodiments, the output interface and the display device can be identical. Output via the output interface can therefore be display via the display device, and vice versa.

[0052] In some embodiments, the computer system according to the invention is programmed to output values ​​indicating set flows and / or the renal dose, such as the target value for the renal dose and / or the actual flows or the setting values ​​for the pumps mentioned herein, e.g. the blood pump, the dialysis fluid pump, the substitution pump, the calcium pump, the citrate pump, the heparin pump and / or other pumps, for example by means of the aforementioned output interface.

[0053] The computer system can be programmed to transmit these values, for example, to a logistics system and / or a billing system. The logistics system and / or a billing system, which may be located outside the computer system but can nevertheless be part of the system according to the invention, can in turn be programmed to monitor, record, store, output, invoice, and / or otherwise process delivery flows, orders, consumption, and the like. Thus, the logistics system can be configured to initiate a reorder of fluids consumed during a blood treatment session, such as citrate solution, dialysis fluid, etc., and their delivery to the clinic where the blood treatment took place, using values ​​transmitted by the computer system.The billing system can use the values ​​transmitted by the computer system to bill for the services provided by the clinic in connection with the blood treatment session. For example, the target renal dose or the value reflecting the consumption of fluids such as heparin, citrate solution, etc., such as the heparin flow rate, can be used as the basis for billing the patient or a payer such as an insurance company.

[0054] In some embodiments, the computer system according to the invention is a control or regulating device of a blood treatment device or is in signal communication with it.

[0055] According to the invention, in some embodiments it is also possible to implement the computer system according to the invention in a control or regulating device of, for example, a conventional blood treatment device, whereby the blood treatment device would in turn be configured as a blood treatment device according to the invention. In these embodiments, existing input and output interfaces as well as the computing device of the blood treatment device could then be advantageously used to implement the computer system according to the invention.

[0056] In some embodiments, the computer system can be or include a server-based solution, where the user can, for example, access a program running on the server via a website to execute or initiate the steps of the method according to the invention. The computer system can thus optionally include a server. It can include user interfaces and / or user devices such as computers, mobile phones, or tablets, which are configured to communicate with the server.

[0057] In some embodiments, the control or regulating device is programmed to control or regulate the blood treatment device based on the setting value for the blood pump and the setting value for the dialysis fluid pump according to the selected combination, particularly after selection has been made.

[0058] In some embodiments, the blood treatment device according to the invention is designed as a hemodialysis device, hemofiltration device or hemodiafiltration device, in particular as a device for acute, chronic or continuous renal replacement therapy (CRRT).

[0059] In some embodiments, the method according to the invention further comprises displaying or outputting the setting value for the blood pump and the setting value for the dialysis fluid pump of the selected combination. The display or output can optionally be performed by means of a display device for the user to acknowledge and / or confirm the information.

[0060] Confirmation can be as simple as pressing an "OK" button or something similar.

[0061] In some implementations, confirmation does not involve typing, entering, selecting, etc., of setting values ​​from a multitude of options, or even calculating them mentally.

[0062] In some embodiments, the method according to the invention comprises, as a further step, the preferably automatic control or regulation of the blood treatment device based on the setting value for the blood pump and the setting value for the dialysis fluid pump of the selected combination.

[0063] This can, for example, follow directly after the user has selected or confirmed their selection.

[0064] In some embodiments, the method according to the invention comprises as a further step the reading of the setting value for the blood pump and the setting value for the dialysis fluid pump of the selected combination into a memory (this can be, for example, volatile or permanent), e.g., of the blood treatment device, for a subsequent or yet to begin treatment or treatment session using the blood treatment device.

[0065] Other parameter values ​​may include or relate to the patient's acid / base balance or the composition of their blood.

[0066] When the terms "programmed" or "configured" are used here, it is also revealed that these terms are interchangeable.

[0067] Some or all embodiments of the invention may have one, several or all of the advantages mentioned above and / or below.

[0068] An advantage of the present invention is that it enables or facilitates the user, usually the treating physician, to decide which settings may be selected for the pumps of the blood treatment device during the upcoming or current blood treatment, in order to simultaneously achieve a predetermined target value that is not also a target setting for one of the pumps. Since the invention allows unfavorable combinations of the numerous possible combinations to be excluded from the outset with regard to the target value, this significantly reduces the complexity of the decision-making task for the physician.

[0069] An advantage of the present invention may therefore further consist in the fact that changing setting values ​​through the simplification according to the invention can advantageously give more security to the less experienced user when setting.

[0070] The probability of errors when finding setting values ​​can be significantly reduced according to the invention, for example because mental calculation steps or the risk of errors in thinking by the user can be eliminated.

[0071] This can indirectly and advantageously increase patient safety.

[0072] However, the responsibility for finding or changing the settings can advantageously remain with the user. The user thus receives valuable support from the computer system according to the invention, but cannot be surprised by its independent actions.

[0073] If the blood treatment device and the computer system remain separate devices, existing blood treatment devices can be combined with the computer system according to the invention to form the system according to the invention. Since no modifications to the control system of the blood treatment device are necessary in this case, no new approval of the blood treatment device as a medical device is required.

[0074] The present invention is explained below by way of example with reference to the accompanying drawing, in which the same reference numerals denote identical or similar components. In the figures of the drawing, the following applies: Fig. 1 The figure shows, in a highly simplified representation, a system according to the invention with a blood treatment device next to a computer system according to the invention; Fig. 2 shows a flowchart of an exemplary embodiment of the method according to the invention; Fig. 3a shows parts of a graphic (or a graphic display) as it could be displayed to the user by means of the display device in an exemplary embodiment of the computer system or method according to the invention; Fig. 3b The graphic shows the Fig. 3a with a marked selection area for new setting values; and Fig. 3c The graphic shows the Fig. 3b during a setup process.

[0075] Fig. 1 Figure 1 shows, in a highly simplified representation, a blood treatment device 100, optionally connected to an extracorporeal blood circulation 300, as part of a system according to the invention.

[0076] The extracorporeal blood circulation 300 has a first conduit 301, here in the form of an arterial conduit section.

[0077] The first line 301 is in fluid connection with a blood treatment device, here by way of example a blood filter or dialyzer 303. The blood filter 303 has a dialyzing fluid chamber 303a and a blood chamber 303b, which are separated from each other by a mostly semi-permeable membrane 303c.

[0078] The extracorporeal blood circulation 300 also includes at least one second line 305, here in the form of a venous line segment. Both the first line 301 and the second line 305 can serve to connect to the vascular system of the patient (not shown).

[0079] The first line 301 is optionally connected to a (first) hose clamp 302 for locking or closing the line 301. The second line 305 is optionally connected to a (second) hose clamp 306 for locking or closing the line 305.

[0080] The in Fig. 1 The blood treatment device 100, represented only by some of its features and schematically, includes a blood pump 101. During the treatment of the patient, the blood pump 101 pumps blood through sections of the extracorporeal blood circulation 300 and towards the blood filter or dialyzer 303, as shown by the small arrowheads which generally indicate the direction of flow in each of the figures.

[0081] Fresh dialysate is pumped from a source 200 along the dialysate inlet line 104 into the dialysate chamber 303a by means of a dialysate pump 121, which can be configured as a roller pump or as an otherwise occluding pump. The dialysate leaves the dialysate chamber 303a as dialysate, optionally enriched with filtrate, towards an optional effluent bag 400 and is referred to therein as effluent.

[0082] Source 200 can be, for example, a bag or a container. Source 200 can also be a fluid line from which online and / or continuously generated or mixed fluid is supplied, e.g., a hydraulic outlet or port of the blood treatment device 100.

[0083] An additional source 201 with a substitute may be provided optionally. It may correspond to source 200 or be a separate source.

[0084] A merely indicated control or regulating device 150 can be configured to regulate or control the blood treatment session.

[0085] The bottom right corner is in Fig. 1 indicated where the optional effluent bag 400 is connected to the blood treatment device 100.

[0086] In addition to the aforementioned blood pump 101, the one in Fig. 1 The arrangement shown also optionally includes a number of further, each optional, pumps, namely pump 111 for substitute, pump 121 for dialysis fluid and pump 131 for the effluent.

[0087] The pump 121 is designed to draw dialysis fluid from a source 200, for example a bag, and supply it to the blood filter 303 via the dialysis fluid inlet line 104 using an optional bag heater H2 and a heating bag.

[0088] The dialysate supplied in this way exits the blood filter 303 via a dialysate drain line 102, supported by the optional pump 131, and can be discarded.

[0089] An optional arterial sensor PS1 is provided for the power supply of the blood pump 101. During patient treatment, it measures the pressure in the arterial line.

[0090] Downstream of blood pump 101, but upstream of blood filter 303 and, if provided, upstream of a heparin injection point 25, an additional, optional pressure sensor PS2 is provided. It measures the pressure upstream of blood filter 303 ("pre-hemofilter").

[0091] A further pressure sensor can be provided as PS4 downstream of the blood filter 303, but preferably upstream of the pump 131, in the dialysate drain line 102 to measure the filtrate pressure of the blood filter 303.

[0092] Blood leaving the blood filter 303 flows through an optional venous blood chamber 29, which may have a venting device 31 and / or an additional pressure sensor PS3.

[0093] The in Fig. 1 The control or regulating device 150 shown can be connected to any of the components mentioned herein - in any case or in particular to the blood pump 101 - by wired or wireless signal connection for the control or regulation of the blood treatment device 100.

[0094] The optional pump 111 is designed to draw substitute from the optional source 201, for example a bag, and supply it to the second line 305 via an optional bag heater H1 and a heated bag.

[0095] In some embodiments, a citrate solution is supplied to line 301 from an optionally provided source of citrate solution, here exemplified as a citrate bag 9, optionally by means of a citrate pump 15. For example, 4% Na3 citrate is supplied from the source of citrate solution.

[0096] An optional addition device, here designed as a calcium pump 12, is provided to supply calcium solution from an optional source, in Fig. 1 For example, a calcium bag 13 is designed to deliver a calcium solution into line 305. A CaCl₂ solution, for instance, is supplied from the calcium solution source. This solution can have a calcium concentration of 91 mmol / l, 100 mmol / l, or another suitable calcium concentration.

[0097] To the right of the blood treatment device 100 is in the Fig. 1 A computer system 1 according to the invention is shown, comprising a computing device 5 and an optional storage device 7. The computer system has a first input interface I1 and a second input interface I2, as well as an output interface I3.

[0098] Blood treatment device 100 and computer system 1 together represent an embodiment of a system according to the invention.

[0099] The computer system 1 can be located on a mobile handheld device, e.g., a mobile phone or tablet, and be spatially separated from the blood treatment device 100. It is located in the Fig. 1 The embodiment shown is not connected to the blood treatment device 100 in signal communication.

[0100] The computer system 1 can be or comprise a server-based solution in which the user can, for example, access a program running on the server via a website to execute or initiate the steps of the method according to the invention. The computer system 1 can thus include a server. It can include user interfaces and / or user devices such as computers, mobile phones, or tablets, which are configured to communicate with the server.

[0101] In embodiments of the blood treatment device other than the one shown here, the computer system is connected to the blood treatment device 100 via signal communication and / or is physically connected to it, or is part thereof. In the latter cases, however, the devices connected in this way are no longer a system according to the invention, but rather a blood treatment device according to the invention.

[0102] The present invention further includes the fact that the computer system 1, unlike as shown here, is identical to or encompassed by the control or regulating device 150.

[0103] Fig. 2 shows a flowchart of an exemplary embodiment of the method according to the invention.

[0104] In this process step S1, the provision of a computer system 1 according to the invention, a blood treatment device 100 according to the invention or a system according to the invention is required.

[0105] In process step S2, a target value and / or a target range for a parameter value for the treatment of a patient, for example for the renal dose, is read in using a blood treatment device 100 or this parameter value is entered using a first input interface I1.

[0106] S3 represents the display of a selection range calculated by the computing device 5 (see reference A in Fig. 3b ), as described above, by means of the display device I3, for example in a graphic, e.g. a diagram.

[0107] In process step S4, one of the displayed combinations is selected by the user using a second input interface I2, which is similar to the one described in Fig. 3b shown, optionally identical to the first input interface.

[0108] In process step S5, the setting value for the blood pump 101 and the setting value for the dialysis fluid pump 121 of the selected combination are output via the output interface.

[0109] Optionally, in process step S6, the setting value for the blood pump 101 and the setting value for the dialysis fluid pump 121 of the selected combination is displayed or output by means of the display device I3 so that the user can take note of it.

[0110] S7 represents the optional procedure step of controlling or regulating the blood treatment device 100 based on the setting value for the blood pump 101 and the setting value for the dialysis fluid pump 121 of the selected combination.

[0111] Fig. 3a shows essential parts of a graphic or graphic display as it could be displayed to the user in an exemplary embodiment of the computer system or in an exemplary embodiment of the method by means of the display device I3.

[0112] In the graph of the graphic display, the vertical axis represents the blood flow [in ml / min] versus the dialysis fluid flow [in ml / h] on the horizontal axis.

[0113] Each point within the diagram shown thus corresponds to a combination of a possible setting Q̇ n for the blood pump flow rate on the one hand and a possible setting Ḋ n for the dialysis fluid pump flow rate on the other. For example, combination K1 corresponds to a blood pump flow rate of 100 ml / min (setting Q̇ 1 = 100 ml / min) with a dialysis fluid pump flow rate of 2000 ml / min (setting Ḋ 1 = 2000 ml / min). Combination K2, on the other hand, represents a blood pump flow rate of 120 ml / min (setting Q̇ 2 = 120 ml / min) with – as in combination K1 – a dialysis fluid pump flow rate of 2000 ml / min (setting Ḋ 2 = 2000 ml / min).

[0114] When a number of such combinations K1, K2, K3, ... are set from a flow rate for the blood pump and a flow rate for the dialysis fluid pump, a calculated expected acid-base status (expected bicarbonate concentration in the serum) results.

[0115] The expected serum bicarbonate concentrations for a range of combinations of blood flow rate and dialysis fluid flow rate are shown in the diagram as rays. The rays shown are labeled B1 to B7. For each ray, the expected bicarbonate concentration (in mmol / L) at the edge of the diagram is indicated (the values ​​in the graph of the Fig. 3a were determined in a simulation).

[0116] The example presented here illustrates that a 20% increase in blood flow from K1 to K2 raises the expected serum bicarbonate concentration by approximately 4 mmol / L (from 24 mmol / L to 28 mmol / L, i.e., towards metabolic alkalosis). A 20% increase in dialysate flow (after K3) would counteract this effect.

[0117] The underlying constant treatment parameters in this example are: citrate dose 4 mmol per liter of blood, calcium dose 1.7 mmol per liter of blood, net ultrafiltration 100 ml / h.

[0118] For the sake of clarity, the selection area available to the user according to the invention is divided into Fig. 3a Not yet shown. It starts with reference A. Fig. 3b and Fig. 3c stand out.

[0119] Fig. 3b The example graphic or graphical display shows the Fig. 3a .

[0120] All explanations regarding Fig. 3a therefore also apply to Fig. 3b to.

[0121] In Fig. 3b Here, a selection range A with an indefinite number n of possible combinations of setting values ​​Q̇ n for the flow rate of the blood pump and setting values ​​Ḋ n for the flow rate of the dialysis fluid pump is shown.

[0122] Selection area A visually highlights those combinations from the n possible combinations for which the corresponding settings are suitable for use on the blood treatment device 100 in order to achieve the target value, e.g., for the renal dose, during or as part of the treatment performed with them. The combinations marked by selection area A are thus selected or determined taking into account the target value for the renal dose.

[0123] Selection area A is in the example the Fig. 3b Marked by hatching. It does not have to be like in the Fig. 3b It may be shown hatched, but can also be highlighted in other ways. Colored backgrounds are also possible. Its shape can, of course, differ from the bar shape shown here.

[0124] Purely by way of example, in Fig. 3b Assume, for example, that the user has selected a combination KB by highlighting it with the computer mouse, which should be indicated by the circle within the selection area A. The setting values ​​Q̇ B for the blood pump flow rate and Ḋ B for the dialysis fluid pump flow rate associated with this combination KB can optionally be displayed to the user, specifying the exact setting values ​​in, for example, ml / min. It may be necessary for the user to confirm these settings before the blood treatment device takes action based on them.

[0125] However, treatment using the set values ​​Q̇ B Ḋ B allows treatment while achieving the desired renal dose, i.e., the target value.

[0126] Displaying or highlighting the selected combination KB can correspond to output via the output interface and / or display via the display device.

[0127] Fig. 3c The diagram shows the Fig. 3b . Contrary to the representation in Fig. 3b However, the user has selected a combination KB that lies outside selection range A. The settings for this combination are not suitable for achieving the target renal dose during a blood treatment performed with them.

[0128] The user can optionally be notified of this by means of a warning, notice, or similar. They may have the option to correct their selection and move the initially selected combination KB into selection area A. If they follow the instructions in Fig. 3c The arrow shown would maintain the bicarbonate concentration he was aiming for. Bezugszeichenliste

[0129] 1 Computer system 5 Computing device 7 Storage device (optional) 9 Source of citrate solution, shown here as a citrate bag 12 Calcium pump 13 Source of calcium solution, calcium bag 15 Citrate pump 25 Heparin injection site (optional) 29 Venous blood chamber (optional) 31 Venting device 100 Blood treatment device 101 Blood pump 102 Dialysate drain line, effluent inlet line 104 Dialysis fluid inlet line 111 Substitute pump 121 Dialysis fluid pump 131 Dialysate or effluent pump in effluent inlet line 150 Control or regulating device 200Source with dialysis fluid 201Source with substitute, optional 300 Extracorporeal blood circulation 301 First line (arterial line) 302 (First) tubing clamp 303 Blood filter or dialyzer 303a Dialysis fluid chamber 303b Blood chamber 303c Semi-permeable membrane 305 Second line (venous line) 306 (Second) tubing clamp Selection area I1 First input interface I2 Second input interface I3 Display device K1 Combination 1 K2 Combination 2 K3 Combination 3 KB Selected combination B1 Expected serum bicarbonate concentration of 30 mmol / l B2 Expected serum bicarbonate concentration of 28 mmol / l B3 Expected serum bicarbonate concentration of 26 mmol / l B4 Expected serum bicarbonate concentration of 24 mmol / l B5 Expected serum bicarbonate concentration of 22 mmol / l B6 Expected serum bicarbonate concentration of 20 mmol / l B7 Expected serum bicarbonate concentration of 18 mmol / l S1 Process step a S2 Process step b S3 Process step c S4 Process step d S5 Process step e S6 Further process step S7 Further process step Q̇ 1 , Q̇ 2 , Q̇ 3 , Q̇ B Blood pump settings Ḋ 1 , Ḋ 2 , Ḋ 3 , Ḋ B Setting values ​​for dialysis fluid pump

Claims

1. A computer system (1) for setting values of a blood treatment apparatus (100), comprising: - a first input interface (I1); - a second input interface (I2); - an output interface; - a calculation device (5); - a display device (I3) wherein the calculation device (5) is programmed: - to read in, by means of the first input interface (I1), a target value for the renal dose as a parameter value for a treatment of a patient by means of the blood treatment apparatus (100); - to display to a user a selection range (A) in a graphic, by means of the display device (I3), wherein the selection range (A) is determined by the calculation device (5) taking into account the read-in target value of the renal dose and a plurality of combinations (K1, K2, K3) of exactly one adjustment value (Q̇1, Q̇2, Q̇3) for the flow of the blood pump (101) on the one hand and exactly one adjustment value (Ḋ1, Ḋ2, Ḋ3) for the flow of the dialysis fluid pump (121) on the other hand are displayed; wherein the second input interface (I2) is designed to allow the user to select a combination (KB) from the displayed combinations (K1, K2, K3); and wherein the calculation device (5) is further programmed: - to output the adjustment value (Q̇B) for the blood pump (101) and the adjustment value (ḊB) for the dialysis fluid pump (121) of the selected combination (KB) by means of the output interface.

2. The computer system (1) according to claim 1, wherein the calculation device (5) is further programmed, - to read in further parameter values (B1, B2, B3, B4, B5, B6, B7); - wherein the selection range (A) is further restricted by the calculation device (5) taking into account the further parameter values (B1 to B7).

3. The computer system (1) according to claim 2, wherein the further parameter values (B1 to B7) take into account or relate to a desired anticoagulation, in particular citrate-calcium anticoagulation, or a desired bicarbonate concentration in the serum.

4. The computer system (1) according to any one of the preceding claims, wherein the computer system (1) is a mobile device, a handheld device, a mobile phone, a smartphone, a tablet, etc. or an application suitable for this purpose.

5. The computer system (1) according to any one of the preceding claims, wherein the calculation device (5) is programmed to display or output, for the user's attention, by means of the display device (I3), the adjustment value (Q̇B) for the blood pump (101) and the adjustment value (ḊB) for the dialysis fluid pump (121) of the selected combination (KB).

6. The computer system (1) according to any one of the preceding claims, wherein the computer system (1) is a control or regulating device (150) of the blood treatment apparatus (100) or is in signal communication therewith.

7. The computer system (1) according to claim 6, wherein the control or regulating device (150) is programmed to control or regulate the blood treatment apparatus (100) on the basis of the adjustment value (Q̇B) for the blood pump (101) and the adjustment value (ḊB) for the dialysis fluid pump (121) of the selected combination (KB).

8. A blood treatment apparatus (100), designed as a dialysis apparatus, comprising a computer system (1) according to any one of the preceding claims.

9. The blood treatment apparatus (100) according to claim 8, designed as a hemodialysis apparatus, hemofiltration apparatus or hemodiafiltration apparatus, in particular as an apparatus for chronic renal replacement therapy or for continuous renal replacement therapy (CRRT).

10. A system comprising or consisting of: - one or more blood treatment apparatuses (100), designed as a dialysis apparatus; - a computer system (1) according to any one of the preceding claims 1 to 7, wherein the one or more blood treatment devices (100) and the computer system (1) are separate from one another.

11. A method for setting adjustment values of a blood treatment apparatus (100) comprising the steps of: - providing a computer system (1) according to any one of claims 1 to 7, a blood treatment apparatus (100) according to any one of claims 8 to 9, or a system according to claim 10; - reading in, by means of the first input interface (I1), a target value for the renal dose as a parameter value for a treatment of a patient by means of the blood treatment apparatus (100) or entering this parameter value; - displaying to the user a selection range (A) in a graphic, by means of the display device (I3), wherein the selection range (A) is determined by the calculation device (5) taking into account the target value of the renal dose and displays a plurality of combinations of exactly one adjustment value (Q̇1, Q̇2, Q̇3) for the flow of the blood pump (101) on the one hand and exactly one adjustment value (Ḋ1, Ḋ2, Ḋ3) for the flow of the dialysis fluid pump (121) on the other hand; - selecting by the user, by means of the second input interface (I2), a combination (KB) from the displayed combinations (K1, K2, K3); and - outputting, by means of the output interface, the adjustment value (Q̇B) for the blood pump (101) and the adjustment value (ḊB) for the dialysis fluid pump (121) of the selected combination (KB).

12. The method according to claim 11, with the further step of: - displaying or outputting, for the user to acknowledge, by means the display device (I3), the adjustment value (Q̇B) for the blood pump (101) and the adjustment value (ḊB) for the dialysis fluid pump (121) of the selected combination (KB).

13. A digital storage medium, in particular in the form of a floppy disk, CD or DVD, EPROM, FRAM or SSD, with electronically readable control signals, configured to interact with a programmable computer system in such a way that the computer system is programmed to become a computer system according to claims 1 to 7.

14. A computer program product, as a signal wave or with a program code stored on a machine-readable carrier, to interact with a programmable computer system in such a way that the computer system is programmed to become a computer system according to claims 1 to 7.