Generation of HPV antigen-specific T cells from a naive T cell population
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- CHILDRENS NAT MEDICAL CENT
- Filing Date
- 2016-10-31
- Publication Date
- 2026-04-15
AI Technical Summary
Current methods struggle to effectively expand HPV-specific T cells from naive donors due to the absence of memory T cells, posing challenges for treating HPV infections and associated malignancies, and existing approaches using viruses or virus-transformed cells are undesirable due to clinical risks and regulatory hurdles.
A method using overlapping peptide libraries pulsed onto antigen-presenting cells, combined with specific cytokines and selection methods, to generate HPV-specific T cells from naive T cells without live viruses, enabling robust expansion and storage for therapeutic use.
The method allows for the rapid and safe production of HPV-specific T cells with a mixed CD4+CD8+ phenotype, capable of recognizing multiple HPV antigens, which can be banked for off-the-shelf use in treating HPV infections and malignancies, and is applicable to other opportunistic viruses and malignancies.