Map4k1 inhibitors

Abstract

The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

Description

[0001] The present disclosure relates to MAP4K1 inhibitors, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

[0002] The present disclosure further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.Background

[0003] Although cancer cell commonly can be recognized by the adaptive immune system, the response generated is evidently not capable of eliminating the tumor. A major reason for this is the presence of immunosuppressive mechanisms in the tumor microenvironment. In this respect, inhibitors of T-cell immune checkpoint such as CTLA-4, PD-1 or PD-L1 were recently shown to result in a remarkable clinical efficacy in subsets of cancer patients. Besides cell surface receptors that act as negative immune regulators, several mediators of intracellular signaling have been identified that also represent potential immunoevasive mechanisms utilized by the tumor.

[0004] One of these is MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 (GenelD11184) is a serine / threonine kinase and member of the Germinal Center Kinase family. In the adult organism MAP4K1 expression is restricted to hematopoietic cell types. The MAP4K1 protein consist of a N-terminal kinase domain, followed by a proline-rich domain that can interact with adaptor molecules through SH2 and SH3 domains, and a C-terminal citron homology domain of which the exact function remains to be identified. Through its proline-rich domain, MAP4K1 is capable of binding to a diversity of adaptors in hematopoietic cells, including those involved in T-cell receptor (TCR), B-cell receptor (BCR) and cytokine signaling (Hu et al., Genes Dev. 1996 Sep 15;10(18):2251-64, 2.; Ling et al.,. J Biol Chem. 2001 Jun 1;276(22), Sauer et al., J Biol Chem. 2001 Nov 30;276(48):45207-16., Tsuji et al., J Exp Med. 2001 Aug 20;194(4):529-39, Boomer et al., J Cell Biochem. 2005 May 1;95(1):34-44).

[0005] The function of MAP4K1 has been studied in greatest detail in the context of TCR signaling. Upon TCR stimulation, MAP4K1 is phosphorylated on tyrosine 381 (Y-381; Y-379 in mouse) (Di Bartolo et al., J Exp Med. 2007 Mar 19;204(3):681-91). Consequently, MAP4K1 is recruited to the TCR-signaling complex where it induces dissociation of this complex through its serine / threonine kinase function. In particular MAP4K1 phosphorylates the SLP-76 adaptor protein at Serine-376, resulting in downregulation of AP-1 and Erk2 pathways. As, such, MAPK1 acts as a negative feedback on TCR-signaling (Liou et al., Immunity. 2000 Apr;12(4):399-408; Lasserre et al., J Cell Biol. 2011 Nov 28;195(5):839-53.). Alternatively, MAP4K1 can be triggered to suppress T cell function by prostaglandin E2 (PGE2), and possibly also by transforming growth factor beta (TGF-beta), factors that are commonly found in the tumor microenvironment. Notably, MAP4K1 activation by these mediators involves protein kinase A (PKA)-dependent phosphorylation of Serine 171 (S-171; also in mouse) (Alzabin et al., Cancer Immunol Immunother. 2010 Mar;59(3):419-29; Sawasdikosol et al., J Biol Chem. 2007 Nov 30;282(48):34693-9.).

[0006] Further important insights into the function of MAP4K1 in the regulation of T cell immunity stem from in vivo and in vitro experiments respectively with MAP4K1 deficient mice produced by two laboratories and with immune cells isolated from these mice (Shui et al., Nat Immunol. 2007 Jan;8(1):84-91; Alzabin et al., Cancer Immunol Immunother. 2010 Mar;59(3):419-29). MAP4K1-deficient mice show an apparent normal phenotype, are fertile and exhibit normal lymphocyte development. These animals are prone to develop T-cell dependent autoimmune reactivity as indicated by development of a more severe disease score in the EAE (experimental autoimmune encephalomyelitis) model of multiple sclerosis (Shui et al., Nat Immunol. 2007 Jan;8(1):84-91). In case of the second strain, a dysregulation of immune function was observed when, at the age of approximately 6 months, MAP4K1-deficient mice develop a spontaneous autoimmune phenotype (Alzabin et al., Cancer Immunol Immunother. 2010 Mar;59(3):419-29). In vitro studies showed that MAP4K1- / - T-cells display hyper-responsiveness upon TCR-stimulation. These cells proliferate and secrete pro-inflammatory cytokines like IL-2 or IFNg to a significantly greater extent than their wild-type counterparts (Shui et al., Nat Immunol. 2007 Jan;8(1):84-91). Furthermore, MAP4K1- / - T-cells are resistant to PGE2-mediated suppression of T cell proliferation, suppression of IL-2 production and induction of apoptosis (Alzabin et al., Cancer Immunol Immunother. 2010 Mar;59(3):419-29). In the context of tumor immunology, in vivo experiments revealed that MAP4K1- / - mice are much more resistant to tumorigenesis by PGE2-producing Lewis lung carcinoma than wild type mice, which correlated with increased T-lymphocyte infiltration in the tumor areas. The crucial role of T-cells in tumor rejection was supported by experiments in which MAP4K1- / - T-cells adoptively transferred into T-cell-deficient mice were able to eradicate tumors more efficiently than wild-type T-cells (Alzabin et al., Cancer Immunol Immunother. 2010 Mar;59(3):419-29). The important role of the kinase enzymatic activity was demonstrated by studies were only wild type MAP4K1, but not the MAP4K1 kinase-dead mutant, could mediate serine-phosphorylation of the TCR-signaling complex component SLP-76 and subsequent binding of SLP-76 to the negative regulator of TCR-signaling 14-3-3-t (Shui et al., Nat Immunol. 2007 Jan;8(1):84-91). MAP4K1 also regulates the stimulation and activation of dendritic cells. MAP4K1 deficient Bone marrow derived cells (BMDC) express after maturation and stimulation higher level of costimulatory molecules and produce more proinflammatory cytokines. Also elimination of tumors was observed to be more efficient by MAP4K1 - / - BMDC compared to their wildtype counterparts (Alzabin et al., J Immunol. 2009 May 15;182(10):6187-94).Prior art

[0007] In WO2019164846A1 HPK1 inhibitors and methods for their use in various forms of cancer are described. These compounds differ from the instant compounds in their chemical structure.

[0008] In US20190256500A1 HPK1 inhibitors and methods for their use in treating, preventing or ameliorating diseases or disorders associated with HPK1 such as cancer are described. These compounds differ from the instant compounds in their chemical structure.

[0009] In US20190256520A1 HPK1 inhibitors and methods for their use in treating, preventing or ameliorating diseases or disorders associated with HPK1 such as cancer are described. These compounds differ from the instant compounds in their chemical structure.

[0010] In CN109721620A HPK1 inhibitors and their uses are described. These compounds differ from the instant compounds in their chemical structure.

[0011] In WO2019090198A1, compounds used to modulate or inhibit the activity of HPK1 and methods for their use in treatment of viral infections and proliferative disorders, such as cancer are described. These compounds differ from the instant compounds in their chemical structure.

[0012] In WO 2018 / 215668, MAP4K1 (HPK1) inhibitors and methods for their use in diseases including hyperproliferative diseases, diseases of immune system dysfunction, intlammatory disorders, neurological diseases, and cardiovascular diseases are described. These compounds differ from the instant compounds in their chemical structure.

[0013] In WO 2018 / 049214, HPK1 modulators and methods for their use in cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0014] In WO 2018 / 049200, HPK1 modulators and methods for their use in cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0015] In WO 2018 / 049152, HPK1 modulators and methods for their use in cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0016] In WO 2018 / 049119, HPK1 modulators and methods for their use in cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0017] In WO 2018 / 102366, HPK1 inhibitors and methods for their use in the treatment of cancer are described. These compounds differ from the instant compounds in their chemical structure. In WO 2018 / 183956, HPK1 inhibitors and use of such compounds in treating HPK1-dependent disorders and enhancing immune response are described. These compounds differ from the instant compounds in their chemical structure.

[0018] In WO 2018 / 183964, HPK1 inhibitors and use of such compounds in treating HPK1-dependent disorders and enhancing immune response are described. These compounds differ from the instant compounds in their chemical structure.

[0019] In WO 2018 / 167147, HPK1 inhibitors and use of such compounds in treating HPK1-dependent disorders and enhancing immune response are described. These compounds differ from the instant compounds in their chemical structure.ln WO

[0020] In WO2016 / 205942 HPK1, respectively inhibitors and methods of their use in cancer treatment are described. Specifically, the application concerns thieno-pyridinones that can be used in anti-cancer therapy. These compounds differ from the instant compounds in their chemical structure.

[0021] In WO 2016 / 195776 inhibitors and methods for leukemia, cancer and diabetes treatment dependent on inhibition the interaction of menin with of MLL1, MLL2 and MLL-fusion oncoproteins are described. These compounds differ from the instant compounds in their chemical structure.

[0022] In WO 2006 / 014325 C-MET modulators and their use in cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0023] In WO 2005 / 058891 Rho kinase inhibitors and their use in cardiovascular and cancer treatment are described. These compounds differ from the instant compounds in their chemical structure.

[0024] In WO 2015 / 089479 several inhibitors are described that show inhibition of several kinases (e.g., BTK, HCK, TAK1 and HPK1). These compounds differ from the instant compounds in their chemical structure.

[0025] In WO2016 / 004272 BTK inhibitors and methods of their use in cancer treatment are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0026] In WO 2011 / 090738 Type II RAF kinase inhibitors and their use in various diseases are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0027] In CN102086211 and WO2006116713 protein kinase inhibitors and their use in prophylaxis and treatment of diseases including cancer are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0028] In WO 2010 / 045095 protein tyrosin kinase modulators and their use in the treatment of hyperproliferative disorders are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0029] In WO 2008 / 089307 compounds and methods of their use in the treatment of pain, inflammation and cancer are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0030] In WO 2006 / 114180 kinase inhibitors for treating diseases, particularly tumors are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0031] In WO 2006 / 014325 c-Met modulators and their methods of use to treat kinase-dependent diseases and conditions are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0032] In US 2003 / 0055049 compounds for treating disorders with abnormal cell growth in mammals are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0033] In WO 2001 / 23389 antagonists of NPY receptors compositions and methods of the treatment of physiological disorders associated with an excess of neuropeptide Y are described. No specific example is disclosed which falls in the group of compounds as defined according to the present invention.

[0034] In WO 2019 / 149738 protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death are described.

[0035] It would therefore be desirable to provide novel MAP4K1 inhibitors having prophylactic and therapeutic properties.

[0036] Accordingly, it is an object of the present invention to provide compounds and pharmaceutical compositions comprising these compounds used for prophylactic and therapeutic applications for hyperproliferative disorders, in particular for cancer, respectively tumour disorders, and conditions with dysregulated immune responses, as a sole agent or in combination with other active ingredients.

[0037] A further object of the present invention is to provide compounds and pharmaceutical compositions comprising these compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

[0038] Surprisingly, the compounds according to the invention inhibit the MAP4K1 protein and thereby enhance tumor immunogenicity leading to inhibition of cancer cells growth by the immune response. Accordingly, they provide novel structures for the therapy of human and animal disorders, in particular of cancers.

[0039] Any references herein to methods of treatment refer to the compounds, pharmaceutical compositions and medicaments of the present invention for use in a method for treatment of the human (or animal) body by therapy (or for diagnosis).

[0040] The present invention relates to compound of formula (I) (if referred to embodiment 1, this group of compounds is meant) wherein Ais selected from a single bond, -CH2- or -O-; Eis -(CH2)n- with n = 1 or 2; Gis -(CH2)- and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 5 membered heterocycloalkyl; Qis selected from N or C-R 2< ; R 1< is selected from -NO 2 ; -CN; C 1-4 -alkyl optionally substituted by -OH or 1 to 3 -F; cyclopropyl; 4 to 6 membered heterocycloalkyl or heterocycloalkenyl, both with 1 - 2 nitrogen atoms, but always linked via a carbon atom to the phenyl group of compounds of formula (I) and both optionally substituted by C 1-4 -alkyl; phenyl optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -C(O)-R d , SR d , SOR d , SO 2 R d , SONR d , SON(H)R d , -SO 2 -NH 2 , - SO 2 -N(H)-R d or -SO 2 -N(R d ) 2 , wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; 5 to 6 membered heteroaryl with 1, 2 or 3 heteroatoms selected from N, O or S and optionally substituted by 1 or 2 of the following substituents: halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalkyl, C 1-3 -alkinyl, SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; -O-CH 3 ; -O-CH(CH 3 ) 2 -O-CHF 2 ; -O-CF 3 ; -O-CHR a -phenyl optionally substituted by one, two or three of the following substituents: halogen, -CN, C 1-4 -alkyl optionally substituted by one or more -F, O-C 1-4 -alkyl, C 1-6 -alkinyl-OH or -SO 2 -CH 3 and with R a selected from -H, -F or -CH 3 , -CF 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or - cyclopropyl; -O-CHR a -6 membered heteroaryl optionally substituted one, two or three of the following substituents: halogen, -CN, C 1-4 -alkyl optionally substituted by one or more -F or -SO 2 -CH 3 and with R a selected from -H, -F or -CH 3 , -CF 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -COOR a with R a selected from -H or -CH 3 ; C(=O)-methyl, optionally substituted by 1 to 3 -F; -C(=O)-NR b R c wherein R b is selected from -H, -CH 3 or -CH 2 -CH 3 and wherein R c is selected from -H, -CH 3 , -CH 2 -CH 3 , cyclohexyl, phenyl or 5 to 6 membered heteroaryl, all optionally substituted by one or two halogen, -CN, -SO 2 -CH 3 or C 1-4 -alkyl, optionally substituted one or more times with halogen; -S-CR f R g R h , wherein R f is selected from -H or -F, wherein R g is selected from -H, -F or -CH 3 and wherein R h is selected from H, F, -CH 3 or C 5-6 -cycloalkyl or phenyl; R 2< is selected from -H; R 4< is selected from C 1-6 -alkyl, C 3-6 -cycloalkyl or C 1-3 -alkyl-C 3-6 -cycloalkyl, all optionally substituted one or independently more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -OR i wherein R i is selected from C 1-4 -alkyl or C 3-6 -Cycloalkyl, both optionally substituted one or more times by halogen, ∘ -CF 3 , -CHF 2 , -CH 2 F, or -CH 2 -CF 3 ; ∘ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl, ∘ -CH 2 -O-CH 3 or ∘ C 3-4 cycloalkyl or 4-6 membered heterocycloalkyl, both optionally substituted by (=O), or optionally substituted one or more times by F or CH 3 ; ∘ C 6-8 -spiro-alkyl and C 5-7 -bicyclo-alkyl ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or ∘ phenyl is optionally substituted one or more times by -C(O)NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl or ∘ 5 to 6 membered heteroaryl is optionally substituted one or more times by -OH; C(=O)-R I in which R I is selected from ∘ C 1-4 -alkyl, C 3-6 -cycloalkyl or C 3-6 -heterocycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl, C 3-6 -cycloalkyl or C 1-3 -alkyl-C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

[0041] The compounds of formula (I) are particularly suitable for a large number of prophylactic and therapeutic applications, in particular for hyperproliferative disorders, for tumour disorders and as proteine inhibitors and further for viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for male fertility control.

[0042] Further, it covers their use in combination with other anti cancer medications such as immunotherapeutics, targeted anti cancer agents, radiation or chemotherapy.DEFINITIONS

[0043] In case an asterix is used in a formula, like for instance in *-A-B or *-A-, this asterix indicates the bond towards the core of the compound.

[0044] The term "substituted" means that one or more hydrogen atoms on the designated atom or group are replaced with a selection from the indicated group, provided that the designated atom's normal valency under the existing circumstances is not exceeded. Combinations of substituents and / or variables are permissible.

[0045] The term "optionally substituted" means that the number of substituents can be equal to or different from zero. Unless otherwise indicated, it is possible that optionally substituted groups are substituted with as many optional substituents as can be accommodated by replacing a hydrogen atom with a non-hydrogen substituent on any available carbon or nitrogen or ... atom. Commonly, it is possible for the number of optional substituents, when present, to be 1, 2, 3, 4 or 5, in particular 1, 2 or 3.

[0046] As used herein, the term "one or more", e.g. in the definition of the substituents of the compounds of general formula (I) of the present invention, means "1, 2, 3, 4 or 5, particularly 1, 2, 3 or 4, more particularly 1, 2 or 3, even more particularly 1 or 2".

[0047] When groups in the compounds according to the invention are substituted, it is possible for said groups to be mono-substituted or poly-substituted with substituent(s), unless otherwise specified. Within the scope of the present invention, the meanings of all groups which occur repeatedly are independent from one another. It is possible that groups in the compounds according to the invention are substituted with one, two or three identical or different substituents, particularly with one substituent.

[0048] As used herein, an oxo substituent represents an oxygen atom, which is bound to a carbon atom or to a sulfur atom via a double bond.

[0049] The term "ring substituent" means a substituent attached to an aromatic or nonaromatic ring which replaces an available hydrogen atom on the ring.

[0050] The term "comprising" when used in the specification includes "consisting of".

[0051] If within the present text any item is referred to as "as mentioned herein", it means that it may be mentioned anywhere in the present text.

[0052] The terms as mentioned in the present text have the following meanings: The term "halogen atom" means a fluorine, chlorine, bromine or iodine atom, particularly a fluorine, chlorine or bromine atom.

[0053] The term "C 1 -C 6 -alkyl" means a linear or branched, saturated, monovalent hydrocarbon group having 1, 2, 3, 4, 5 or 6 carbon atoms, e.g. a methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, isobutyl, tert-butyl, pentyl, isopentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, neo-pentyl, 1,1-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1-ethylbutyl, 2-ethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 2,3-dimethylbutyl, 1,2-dimethylbutyl or 1,3-dimethylbutyl group, or an isomer thereof. Particularly, said group has 1, 2, 3 or 4 carbon atoms ("C 1 -C 4 -alkyl"), e.g. a methyl, ethyl, propyl, isopropyl, butyl, sec-butyl isobutyl, or tert-butyl group, more particularly 1, 2 or 3 carbon atoms ("C 1 -C 3 -alkyl"), e.g. a methyl, ethyl, n-propyl or isopropyl group.

[0054] The term "C 1 -C 6 -hydroxyalkyl" means a linear or branched, saturated, monovalent hydrocarbon group in which the term "C 1 -C 6 -alkyl" is defined supra, and in which 1, 2 or 3 hydrogen atoms are replaced with a hydroxy group, e.g. a hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 1-hydroxypropyl, 1-hydroxypropan-2-yl, 2-hydroxypropan-2-yl, 2,3-dihydroxypropyl, 1,3-dihydroxypropan-2-yl, 3-hydroxy-2-methyl-propyl, 2-hydroxy-2-methyl-propyl, 1-hydroxy-2-methyl-propyl group.

[0055] The term "C 1 -C 6 -haloalkyl" means a linear or branched, saturated, monovalent hydrocarbon group in which the term "C 1 -C 6 -alkyl" is as defined supra, and in which one or more of the hydrogen atoms are replaced, identically or differently, with a halogen atom. Particularly, said halogen atom is a fluorine atom. Said C 1 -C 6 -haloalkyl group is, for example, fluoromethyl, difluoromethyl, trifluoromethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 3,3,3-trifluoropropyl or 1,3-difluoropropan-2-yl. Preference is given to perfluorinated alkyl radicals which are named as "perfluoro-C 1 -C x -alkyl-" wherein x is the maximum number of carbon atoms such as trifluoromethyl or 2,2,2-trifluoroethyl.

[0056] The term "C 1 -C 6 -cyanoalkyl" means a linear or branched, saturated, monovalent hydrocarbon group in which the term "C 1 -C 6 -alkyl" is as defined supra, and in which one or more of the hydrogen atoms are replaced, identically or differently, with a cyano group.

[0057] The term "C 1 -C 6 -alkoxy" means a linear or branched, saturated, monovalent group of formula (C 1 -C 6 -alkyl)-O-, in which the term "C 1 -C 6 -alkyl" is as defined supra, e.g. a methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec-butoxy, isobutoxy, tert-butoxy, pentyloxy, isopentyloxy or n-hexyloxy group, or an isomer thereof.

[0058] The term "C 1 -C 6 -haloalkoxy" means a linear or branched, saturated, monovalent C 1 -C 6 -alkoxy group, as defined supra, in which one or more of the hydrogen atoms is replaced, identically or differently, with a halogen atom. Particularly, said halogen atom is a fluorine atom. Said C 1 -C 6 -haloalkoxy group is, for example, fluoromethoxy, difluoromethoxy, trifluoromethoxy or 2,2,2-trifluoroethoxy. Preference is given to perfluorinated alkyl radicals which are named as "perfluoro-C 1 -C x -alkoxy-" wherein x is the maximum number of carbon atoms such as trifluoromethoxy and 2,2,2-trifluoroethoxy radicals.

[0059] The term "C 1 -C 6 -cyanoalkoxy" means a linear or branched, saturated, monovalent C 1 -C 6 -alkoxy group, as defined supra, in which one or more of the hydrogen atoms is replaced, identically or differently, with a cyano group.

[0060] Mono-(C 1 -C 4 )-alkylamino in the context of the invention means an amino group with one straight-chain or branched alkyl substituent which contains 1, 2, 3 or 4 carbon atoms, such as: methylamino, ethylamino, n-propylamino, isopropylamino, n-butylamino, and tert-butylamino, for example.

[0061] Di-(C 1 -C 4 )-alkylamino in the context of the invention means an amino group with two identical or different straight-chain or branched alkyl substituents which each contain 1, 2, 3 or 4 carbon atoms, such as: N,N-dimethylamino, N,N-diethylamino, N-ethyl-N-methylamino, N-methyl-N-n-propylamino, N-isopropyl-N-methylamino, N-isopropyl-N-n-propylamino, N,N-diisopropylamino, N-n-butyl-N-methylamino, and N-tert-butyl-N-methylamino, for example.

[0062] (C 1 -C 4 )-Alkylcarbonyl in the context of the invention means a straight-chain or branched alkyl group having having 1, 2, 3 or 4 carbon atoms which is bound to the rest of the molecule via a carbonyl group [-C(=O)-], such as: acetyl, propionyl, n-butyryl, isobutyryl, n-pentanoyl, and pivaloyl, for example.

[0063] (C 1 -C 4 )-Alkylcarbonyloxy in the context of the invention means a straight-chain or branched alkyl group having 1, 2, 3 or 4 carbon atoms which is bound to the rest of the molecule via a carboxy group [-C(=O)-O-], such as: acetoxy (=acyloxy), propionyloxy, n-butyryloxy, isobutyryloxy, n-pentanoyloxy, and pivaloyloxy, for example.

[0064] Mono-(C 1 -C 4 )-alkylaminocarbonyl in the context of the invention means an amino group which is bound to the rest of the molecule via a carbonyl group [-C(=O)-] and which has one straight-chain or branched alkyl substituent having 1, 2, 3 or 4 carbon atoms, such as: methylaminocarbonyl, ethylaminocarbonyl, n-propylaminocarbonyl, isopropylaminocarbonyl, n-butylaminocarbonyl, and tert-butylaminocarbonyl, for example.

[0065] Di-(C 1 -C 4 )-alkylaminocarbonyl in the context of the invention means an amino group which is bound to the rest of the molecule via a carbonyl group [-C(=O)-] and which has two identical or different straight-chain or branched alkyl substituents having in each case 1, 2, 3 or 4 carbon atoms, such as: N,N-dimethylaminocarbonyl, N,N-diethylaminocarbonyl, N-ethyl-N-methylaminocarbonyl, N-methyl-N-n-propylaminocarbonyl, N-isopropyl-N-methylaminocarbonyl, N,N-diisopropylaminocarbonyl, N-n-butyl-N-methylaminocarbonyl, and N-tert-butyl-N-methylaminocarbonyl, for example.

[0066] Mono-(C 1 -C 4 )-alkylaminosulfonyl in the context of the invention means an amino group which is bound to the rest of the molecule via a sulfonyl group [-S(=O) 2 -] and which has one straight-chain or branched alkyl substituent having 1, 2, 3 or 4 carbon atoms, such as: methylaminosulfonyl, ethylaminosulfonyl, n-propylaminosulfonyl, isopropylaminosulfonyl, n-butylamino sulfonyl, and tert-butylaminosulfonyl, for example.

[0067] Di-(C 1 -C 4 )-alkylaminosulfonyl in the context of the invention means an amino group which is bound to the rest of the molecule via a sulfonyl group [-S(=O) 2 -] and which has two identical or different straight-chain or branched alkyl substituents having in each case 1, 2, 3 or 4 carbon atoms, such as: N,N-dimethylaminosulfonyl, N,N-diethylaminosulfonyl, N-ethyl-N-methylaminosulfonyl, N-methyl-N-n-propylaminosulfonyl, N-isopropyl-N-methylaminosulfonyl, N,N-diisopropylaminosulfonyl, N-n-butyl-N-methylaminosulfonyl, and N-tert-butyl-N-methylaminosulfonyl, for example.

[0068] The term "C 3 -C 8 -cycloalkyl" means a saturated, monovalent, mono- or bicyclic hydrocarbon ring which contains 3, 4, 5, 6, 7 or 8 carbon atoms ("C 3 -C 8 -cycloalkyl"). Said C 3 -C 8 -cycloalkyl group is for example, a monocyclic hydrocarbon ring, e.g. a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl group, or a bicyclic hydrocarbon ring, e.g. a bicyclo[4.2.0]octyl or octahydropentalenyl.

[0069] The term "C 3 -C 8 -cycloalkoxy" means a saturated, monovalent, mono- or bicyclic group of formula (C 3 -C 8 -cycloalkyl)-O-, which contains 3, 4, 5, 6, 7 or 8 carbon atoms, in which the term "C 3 -C 8 -cycloalkyl" is defined supra, e.g. a cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, cycloheptyloxy or cyclooctyloxy group.

[0070] The terms "4- to 7-membered heterocycloalkyl" and "4- to 6-membered heterocycloalkyl" mean a monocyclic, saturated or unsaturated heterocycle with 4, 5, 6 or 7 or, respectively, 4, 5 or 6 ring atoms in total, which contains one or two identical or different ring heteroatoms from the series N, O and S, it being possible for said heterocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms or, if present, a nitrogen atom. A carbon atom may be substituted with an oxo group or or the sulphur atom with one or two oxo groups to form a -C=O, -S(=O)- or - S(=O) 2 -group in the ring.

[0071] Said heterocycloalkyl group, without being limited thereto, can be a 4-membered ring, such as azetidinyl, oxetanyl or thietanyl, for example; or a 5-membered ring, such as tetrahydrofuranyl, 1,3-dioxolanyl, thiolanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, 1,1-dioxidothiolanyl, 1,2-oxazolidinyl, 1,3-oxazolidinyl or 1,3-thiazolidinyl, for example; or a 6-membered ring, such as tetrahydropyranyl, tetrahydrothiopyranyl, piperidinyl, morpholinyl, dithianyl, thiomorpholinyl, piperazinyl, 1,3-dioxanyl, 1,4-dioxanyl or 1,2-oxazinanyl, for example, or a 7-membered ring, such as azepanyl, 1,4-diazepanyl or 1,4-oxazepanyl, for example.

[0072] Particularly, "4- to 6-membered heterocycloalkyl" means a 4- to 6-membered heterocycloalkyl as defined supra containing one ring nitrogen atom and optionally one further ring heteroatom from the series: N, O, S. More particularly, "5- or 6-membered heterocycloalkyl" means a monocyclic, saturated heterocycle with 5 or 6 ring atoms in total, containing one ring nitrogen atom and optionally one further ring heteroatom from the series: N, O.

[0073] The term "bridged heterocycloalkyl" means a bicyclic, saturated or unsaturated heterocycle with 7, 8, 9 or 10 ring atoms in total (= "bridged bicyclic 7- to 10-membered heterocycloalkyl"), in which the two rings share two common ring atoms which are not adjacent, which "bridged heterocycloalkyl" contains one or two identical or different ring heteroatoms from the series: N, O, S; it being possible for said bridged heterocycloalkyl group to be attached to the rest of the molecule via any one of the carbon atoms, except the spiro carbon atom, or, if present, a nitrogen atom. A carbon atom may be substituted with an oxo group or or the sulphur atom with one or two oxo groups to form a -C=O, - S(=O)- or -S(=O) 2 -group in the ring.

[0074] Said bridged heterocycloalkyl group is, for example, azabicyclo[2.2.1]heptyl, oxazabicyclo[2.2.1]heptyl, thiazabicyclo[2.2.1]heptyl, diazabicyclo[2.2.1]heptyl, azabicyclo-[2.2.2]octyl, diazabicyclo[2.2.2]octyl, oxazabicyclo[2.2.2]octyl, thiazabicyclo[2.2.2]octyl, azabicyclo[3.2.1]octyl, diazabicyclo[3.2.1]octyl, oxazabicyclo[3.2.1]octyl, thiazabicyclo[3.2.1]octyl, azabicyclo[3.3.1]nonyl, diazabicyclo[3.3.1]nonyl, oxazabicyclo[3.3.1]nonyl, thiazabicyclo[3.3.1]nonyl, azabicyclo[4.2.1]nonyl, diazabicyclo[4.2.1]nonyl, oxazabicyclo[4.2.1]nonyl, thiazabicyclo[4.2.1]nonyl, azabicyclo[3.3.2]decyl, diazabicyclo[3.3.2]decyl, oxazabicyclo[3.3.2]decyl, thiazabicyclo[3.3.2]decyl or azabicyclo[4.2.2]decyl.

[0075] The term "heteroaryl" means a monovalent, monocyclic, bicyclic or tricyclic aromatic ring having 5, 6, 8, 9, 10, 11, 12, 13 or 14 ring atoms (a "5- to 14-membered heteroaryl" group), particularly 5, 6, 9 or 10 ring atoms, which contains at least one ring heteroatom and optionally one, two or three further ring heteroatoms from the series: N, O and / or S, and which is bound via a ring carbon atom or optionally via a ring nitrogen atom (if allowed by valency).

[0076] Said heteroaryl group can be a 5-membered heteroaryl group, such as, for example, thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl or tetrazolyl; or a 6-membered heteroaryl group, such as, for example, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl; or a tricyclic heteroaryl group, such as, for example, carbazolyl, acridinyl or phenazinyl; or a 9-membered heteroaryl group, such as, for example, benzofuranyl, benzothienyl, benzoxazolyl, benzisoxazolyl, benzimidazolyl, benzothiazolyl, benzotriazolyl, indazolyl, indolyl, isoindolyl, indolizinyl or purinyl; or a 10-membered heteroaryl group, such as, for example, quinolinyl, quinazolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinoxalinyl or pteridinyl.

[0077] In general, and unless otherwise mentioned, the heteroaryl or heteroarylene groups include all possible isomeric forms thereof, e.g.: tautomers and positional isomers with respect to the point of linkage to the rest of the molecule. Thus, for some illustrative non-restricting examples, the term pyridinyl includes pyridin-2-yl, pyridin-3-yl and pyridin-4-yl; or the term thienyl includes thien-2-yl and thien-3-yl.

[0078] Particularly, the heteroaryl group is a 5-membered heteroaryl group, such as, for example, thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl or tetrazolyl; or a 6-membered heteroaryl group group such as, for example, pyridinyl (=pyridyl), pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl.

[0079] The term "C 1 -C 6 ", as used in the present text, e.g. in the context of the definition of "C 1 -C 6 -alkyl", "C 1 -C 6 -haloalkyl", "C 1 -C 6 -hydroxyalkyl", "C 1 -C 6 -alkoxy" or "C 1 -C 6 -haloalkoxy" means an alkyl group having a finite number of carbon atoms of 1 to 6, i.e. 1, 2, 3, 4, 5 or 6 carbon atoms.

[0080] Further, as used herein, the term "C 3 -C 8 ", as used in the present text, e.g. in the context of the definition of "C 3 -C 8 -cycloalkyl", means a cycloalkyl group having a finite number of carbon atoms of 3 to 8, i.e. 3, 4, 5, 6, 7 or 8 carbon atoms.

[0081] When a range of values is given, said range encompasses each value and sub-range within said range.

[0082] For example: "C 1 -C 6 " encompasses C 1 , C2, C 3 , C 4 , C 5 , C 6 , C 1 -C 6 , C 1 -C 5 , C 1 -C 4 , C 1 -C 3 , C 1 -C 2 , C 2 -C 6 , C 2 -C 5 , C 2 -C 4 , C 2 -C 3 , C 3 -C 6 , C 3 -C 5 , C 3 -C 4 , C 4 -C 6 , C 4 -C 5 , and C 5 -C 6 ; "C 2 -C 6 " encompasses C 2 , C 3 , C 4 , C 5 , C 6 , C 2 -C 6 , C 2 -C 5 , C 2 -C 4 , C 2 -C 3 , C 3 -C 6 , C 3 -C 5 , C 3 -C 4 , C 4 -C 6 , C 4 -C 5 , and C 5 -C 6 ; "C 3 -C 10 " encompasses C 3 , C 4 , C 5 , C 6 , C 7 , C 8 , C 9 , C 10 , C 3 -C 10 , C 3 -C 9 , C 3 -C 8 , C 3 -C 7 , C 3 -C 6 , C 3 -C 5 , C 3 -C 4 , C 4 -C 10 , C 4 -C 9 , C 4 -C 8 , C 4 -C 7 , C 4 -C 6 , C 4 -C 5 , C 5 -C 10 , C 5 -C 9 , C 5 -C 8 , C 5 -C 7 , C 5 -C 6 , C 6 -C 10 , C 6 -C 9 , C 6 -C 8 , C 6 -C 7 , C 7 -C 10 , C 7 -C 9 , C 7 -C 8 , C 8 -C 10 , C 8 -C 9 and C 9 -C 10 ; "C 3 -C 8 " encompasses C 3 , C 4 , C 5 , C 6 , C 7 , C 8 , C 3 -C 8 , C 3 -C 7 , C 3 -C 6 , C 3 -C 5 , C 3 -C 4 , C 4 -C 8 , C 4 -C 7 , C 4 -C 6 , C 4 -C 5 , C 5 -C 8 , C 5 -C 7 , C 5 -C 6 , C 6 -C 8 , C 6 -C 7 and C 7 -C 8 ; "C 3 -C 6 " encompasses C 3 , C 4 , C 5 , C 6 , C 3 -C 6 , C 3 -C 5 , C 3 -C 4 , C 4 -C 6 , C 4 -C 5 , and C 5 -C 6 ; "C 4 -C 8 " encompasses C 4 , C 5 , C 6 , C 7 , C 8 , C 4 -C 8 , C 4 -C 7 , C 4 -C 6 , C 4 -C 5 , C 5 -C 8 , C 5 -C 7 , C 5 -C 6 , C 6 -C 8 , C 6 -C 7 and C 7 -C 8 ; "C 4 -C 7 " encompasses C 4 , C 5 , C 6 , C 7 , C 4 -C 7 , C 4 -C 6 , C 4 -C 5 , C 5 -C 7 , C 5 -C 6 and C 6 -C 7 ; "C 4 -C 6 " encompasses C 4 , C 5 , C 6 , C 4 -C 6 , C 4 -C 5 and C 5 -C 6 ; "C 5 -C 10 " encompasses C 5 , C 6 , C 7 , C 8 , C 9 , C 10 , C 5 -C 10 , C 5 -C 9 , C 5 -C 8 , C 5 -C 7 , C 5 -C 6 , C 6 -C 10 , C 6 -C 9 , C 6 -C 8 , C 6 -C 7 , C 7 -C 10 , C 7 -C 9 , C 7 -C 8 , C 8 -C 10 , C 8 -C 9 and C 9 -C 10 ; "C 6 -C 10 " encompasses C 6 , C 7 , C 8 , C 9 , C 10 , C 6 -C 10 , C 6 -C 9 , C 6 -C 8 , C 6 -C 7 , C 7 -C 10 , C 7 -C 9 , C 7 -C 8 , C 8 -C 10 , C 8 -C 9 and C 9 -C 10 .

[0083] As used herein, the term "leaving group" means an atom or a group of atoms that is displaced in a chemical reaction as stable species taking with it the bonding electrons. In particular, such a leaving group is selected from the group comprising: halide, in particular fluoride, chloride, bromide or iodide, (methylsulfonyl)oxy, [(trifluoromethyl)sulfonyl]oxy, [(nonafluorobutyl)sulfonyl]oxy, (phenylsulfonyl)oxy, [(4-methylphenyl)sulfonyl]oxy, [(4-bromophenyl)sulfonyl]oxy, [(4-nitrophenyl)sulfonyl]oxy, [(2-nitrophenyl)sulfonyl]oxy, [(4-isopropylphenyl)sulfonyl]oxy, [(2,4,6-triisopropylphenyl)sulfonyl]oxy, [(2,4,6-trimethylphenyl)sulfonyl]oxy, [(4-tert-butylphenyl)sulfonyl]oxy and [(4-methoxyphenyl)sulfonyl]oxy.

[0084] Where the plural form of the word compounds, salts, polymorphs, hydrates, solvates and the like, is used herein, this is taken to mean also a single compound, salt, polymorph, isomer, hydrate, solvate or the like.

[0085] By "stable compound' or "stable structure" is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent.

[0086] The compounds of the present invention optionally contain one or more asymmetric centres, depending upon the location and nature of the various substituents desired. It is possible that one or more asymmetric carbon atoms are present in the (R) or (S) configuration, which can result in racemic mixtures in the case of a single asymmetric centre, and in diastereomeric mixtures in the case of multiple asymmetric centres. In certain instances, it is possible that asymmetry also be present due to restricted rotation about a given bond, for example, the central bond adjoining two substituted aromatic rings of the specified compounds.

[0087] Preferred compounds are those which produce the more desirable biological activity. Separated, pure or partially purified stereoisomers or racemic or diastereomeric mixtures of the compounds of the present invention are also included within the scope of the present invention. The purification and the separation of such materials can be accomplished by standard techniques known in the art.

[0088] Preferred stereoisomers are those which produce the more desirable biological activity. These separated, pure or partially purified stereoisomers or racemic mixtures of the compounds of this invention are also included within the scope of the present invention. The purification and the separation of such materials can be accomplished by standard techniques known in the art. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example, by the formation of diastereoisomeric salts using an optically active acid or base or formation of covalent diastereomers. Examples of appropriate acids are tartaric, diacetyltartaric, ditoluoyltartaric and camphorsulfonic acid. Mixtures of diastereoisomers can be separated into their individual diastereomers on the basis of their physical and / or chemical differences by methods known in the art, for example, by chromatography or fractional crystallisation. The optically active bases or acids are then liberated from the separated diastereomeric salts. A different process for separation of optical isomers involves the use of chiral chromatography (e.g., HPLC columns using a chiral phase), with or without conventional derivatisation, optimally chosen to maximise the separation of the enantiomers. Suitable HPLC columns using a chiral phase are commercially available, such as those manufactured by Daicel, e.g., Chiracel OD and Chiracel OJ, for example, among many others, which are all routinely selectable. Enzymatic separations, with or without derivatisation, are also useful. The optically active compounds of the present invention can likewise be obtained by chiral syntheses utilizing optically active starting materials.

[0089] In order to distinguish different types of isomers from each other reference is made to IUPAC Rules Section E (Pure Appl Chem 45, 11-30, 1976).

[0090] The present invention includes all possible stereoisomers of the compounds of the present invention as single stereoisomers, or as any mixture of said stereoisomers, e.g. (R)- or (S)- isomers, in any ratio. Isolation of a single stereoisomer, e.g. a single enantiomer or a single diastereomer, of a compound of the present invention is achieved by any suitable state of the art method, such as chromatography, especially chiral chromatography, for example.

[0091] The present invention includes all possible tautomers of the compounds of the present invention as single tautomers, or as any mixture of said tautomers, in any ratio.

[0092] Further, the compounds of the present invention can exist as N-oxides, which are defined in that at least one nitrogen of the compounds of the present invention is oxidised. The present invention includes all such possible N-oxides.

[0093] The present invention also covers useful forms of the compounds of the present invention, such as metabolites, hydrates, solvates, prodrugs, salts, in particular pharmaceutically acceptable salts, and / or co-precipitates.

[0094] The compounds of the present invention can exist as a hydrate, or as a solvate, wherein the compounds of the present invention contain polar solvents, in particular water, methanol or ethanol for example, as structural element of the crystal lattice of the compounds. It is possible for the amount of polar solvents, in particular water, to exist in a stoichiometric or non-stoichiometric ratio. In the case of stoichiometric solvates, e.g. a hydrate, hemi-, (semi-), mono-, sesqui-, di-, tri-, tetra-, penta- etc. solvates or hydrates, respectively, are possible. The present invention includes all such hydrates or solvates.

[0095] Further, it is possible for the compounds of the present invention to exist in free form, e.g. as a free base, or as a free acid, or as a zwitterion, or to exist in the form of a salt. Said salt may be any salt, either an organic or inorganic addition salt, particularly any pharmaceutically acceptable organic or inorganic addition salt, which is customarily used in pharmacy, or which is used, for example, for isolating or purifying the compounds of the present invention.

[0096] The term "pharmaceutically acceptable salt" refers to an inorganic or organic acid addition salt of a compound of the present invention. For example, see S. M. Berge, et al. "Pharmaceutical Salts," J. Pharm. Sci. 1977, 66, 1-19.

[0097] A suitable pharmaceutically acceptable salt of the compounds of the present invention may be, for example, an acid-addition salt of a compound of the present invention bearing a nitrogen atom, in a chain or in a ring, for example, which is sufficiently basic, such as an acid-addition salt with an inorganic acid, or "mineral acid", such as hydrochloric, hydrobromic, hydroiodic, sulfuric, sulfamic, bisulfuric, phosphoric, or nitric acid, for example, or with an organic acid, such as formic, acetic, acetoacetic, pyruvic, trifluoroacetic, propionic, butyric, hexanoic, heptanoic, undecanoic, lauric, benzoic, salicylic, 2-(4-hydroxybenzoyl)-benzoic, camphoric, cinnamic, cyclopentanepropionic, digluconic, 3-hydroxy-2-naphthoic, nicotinic, pamoic, pectinic, 3-phenylpropionic, pivalic, 2-hydroxyethanesulfonic, itaconic, trifluoromethanesulfonic, dodecylsulfuric, ethanesulfonic, benzenesulfonic, para-toluenesulfonic, methanesulfonic, 2-naphthalenesulfonic, naphthalinedisulfonic, camphorsulfonic acid, citric, tartaric, stearic, lactic, oxalic, malonic, succinic, malic, adipic, alginic, maleic, fumaric, D-gluconic, mandelic, ascorbic, glucoheptanoic, glycerophosphoric, aspartic, sulfosalicylic, or thiocyanic acid, for example.

[0098] Further, another suitably pharmaceutically acceptable salt of a compound of the present invention which is sufficiently acidic, is an alkali metal salt, for example a sodium or potassium salt, an alkaline earth metal salt, for example a calcium, magnesium or strontium salt, or an aluminium or a zinc salt, or an ammonium salt derived from ammonia or from an organic primary, secondary or tertiary amine having 1 to 20 carbon atoms, such as ethylamine, diethylamine, triethylamine, ethyldiisopropylamine, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, dimethylaminoethanol, diethylaminoethanol, tris(hydroxymethyl)aminomethane, procaine, dibenzylamine, N-methylmorpholine, arginine, lysine, 1,2-ethylenediamine, N-methylpiperidine, N-methyl-glucamine, N,N-dimethyl-glucamine, N-ethyl-glucamine, 1,6-hexanediamine, glucosamine, sarcosine, serinol, 2-amino-1,3-propanediol, 3-amino-1,2-propanediol, 4-amino-1,2,3-butanetriol, or a salt with a quarternary ammonium ion having 1 to 20 carbon atoms, such as tetramethylammonium, tetraethylammonium, tetra(n-propyl)ammonium, tetra(n-butyl)ammonium, N-benzyl-N,N,N-trimethylammonium, choline or benzalkonium.

[0099] Those skilled in the art will further recognise that it is possible for acid addition salts of the claimed compounds to be prepared by reaction of the compounds with the appropriate inorganic or organic acid via any of a number of known methods. Alternatively, alkali and alkaline earth metal salts of acidic compounds of the present invention are prepared by reacting the compounds of the present invention with the appropriate base via a variety of known methods.

[0100] The present invention includes all possible salts of the compounds of the present invention as single salts, or as any mixture of said salts, in any ratio.

[0101] In the present text, in particular in the Experimental Section, for the synthesis of intermediates and of examples of the present invention, when a compound is mentioned as a salt form with the corresponding base or acid, the exact stoichiometric composition of said salt form, as obtained by the respective preparation and / or purification process, is, in most cases, unknown.

[0102] Unless specified otherwise, suffixes to chemical names or structural formulae relating to salts, such as "hydrochloride", "trifluoroacetate", "sodium salt", or "x HCl", "x CF 3 COOH", "x Na +< ", for example, mean a salt form, the stoichiometry of which salt form not being specified.

[0103] This applies analogously to cases in which synthesis intermediates or example compounds or salts thereof have been obtained, by the preparation and / or purification processes described, as solvates, such as hydrates, with (if defined) unknown stoichiometric composition.

[0104] Furthermore, the present invention includes all possible crystalline forms, or polymorphs, of the compounds of the present invention, either as single polymorph, or as a mixture of more than one polymorph, in any ratio.

[0105] Moreover, the non-claimed disclosure also includes prodrugs of the compounds according to the invention. The term "prodrugs" here designates compounds which themselves can be biologically active or inactive, but are converted (for example metabolically or hydrolytically) into compounds according to the invention during their residence time in the body.

[0106] The invention further includes all possible crystallized and polymorphic forms of the inventive compounds, whereby the polymorphs are existing either as a single polymorph form or are existing as a mixture of several polymorphs in all concentrations.

[0107] The invention further includes all possible cyclodextrin clathrates, i.e alpha-, beta-, or gamma-cyclodextrins, hydroxypropyl-beta-cyclodextrins, methylbetacyclodextrins.

[0108] The invention also covers the following embodimdents:Embodiment 2:

[0109] Compound of formula (la) wherein Ais selected from a single bond, -CH 2 - or -O-; Eis -(CH 2 ) n - with n = 1 or 2; Gis -(CH 2 )- and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 5 membered heterocycloalkyl; R 1< is selected from -NO 2 ; -CN; C 1-4 -alkyl optionally substituted by -OH or 1 to 3 -F; cyclopropyl; 4 to 6 membered heterocycloalkyl or heterocycloalkenyl, both with 1- 2 nitrogen atoms, but always linked via a carbon atom to the phenyl group of compounds of formula (I) and both optionally substituted by C 1-4 -alkyl; phenyl optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -C(O)-R d , SR d , SOR d , SO 2 R d , SONR d , SON(H)R d , -SO 2 -NH 2 , - SO 2 -N(H)-R d or -SO 2 -N(R d ) 2 , wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; 5 to 6 membered heteroaryl with 1 or 2 heteroatoms selected from N or S and optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalkyl, C 1-3 -alkinyl, SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; -O-CH 3 ; -O-CH(CH 3 ) 2 ; -O-CHF 2 ; -O-CF 3 ; -O-CHR a -phenyl optionally substituted by one or two of the following substituents: halogen, - CN, C 1-4 -alkyl optionally substituted by one or more -F or -SO 2 -CH 3 and with R a selected from -H, -F or -CH 3 , -CF 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -O-CHR a -6 membered heteroaryl optionally substituted one or two of the following substituents: halogen, -CN, C 1-4 -alkyl optionally substituted by one or more -F or -SO 2 -CH 3 and with R a selected from -H, -F or -CH 3 , -CF 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -COOR a with R a selected from -H or -CH 3 ; C(=O)-methyl, optionally substituted by 1 to 3 -F; -C(=O)-NR b R c wherein R b is selected from -H, -CH 3 or -CH 2 -CH 3 and wherein R c is selected from -H, -CH 3 , -CH 2 -CH 3 , cyclohexyl, phenyl or 5 to 6 membered heteroaryl, all optionally substituted by one or two halogen, -CN, -SO 2 -CH 3 or C 1-4 -alkyl, optionally substituted one or more times with halogen; -S-CR f R g R h , wherein R f is selected from -H or -F, wherein R g is selected from -H, -F or -CH 3 and wherein R h is selected from H, F, -CH 3 or C 5-6 -Cycloalkyl or phenyl; R 2< is selected from -H,; or R 4< is selected from C 1-5 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or independently more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -OR i wherein R i is selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), ∘ -CF 3 , -CHF 2 , -CH 2 F, or -CH 2 -CF 3 ; ∘ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl, ∘ -CH 2 -O-CH 3 or ∘ C 3-4 cycloalkyl or 4 membered heterocycloalkyl, both optionally substituted by -F or - CH 3 ; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-R l in which R l is selected from ∘ C 1-4 -alkyl, C 3-6 -cycloalkyl or C 3-6 -heterocycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 3:

[0110] Compounds of formula (I) according to embodiment 1, wherein A is selected from a single bond or - O- or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 4:

[0111] Compounds of formula (I) according to embodiment 1, wherein E is -CH 2 -CH 2 - or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 5:

[0112] Compounds of formula (I) according to embodiment 1, wherein Q is C-R 2< or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 6:

[0113] Compounds of formula (I) according to embodiment 1, wherein Q is N or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 7:

[0114] Compounds of formula (I) according to embodiment 1, wherein R 4 is and R q is selected from H, -CH 3 ,-CH 2 -CH 3 , -CH(CH 3 ) 2 , -CH 2 -O-CH 3 , -CF 3 , -CHF 2 , -CH 2 F, -CH 2 -CF 3 , cyclopropyl or cyclobutyl or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 8:

[0115] Compounds of formula (I) according to embodiment 1, wherein R 4 is selected from C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment 9:

[0116] Compound according to embodiment 1, which is selected from: (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1R)-1-[3-(trifluoromethyl)phenyl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1S)-1-[3-(trifluoromethyl)phenyl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-phenyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1S)-1-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1,2-oxazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(oxan-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-ethyl-5-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-methyl-1H-benzimidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(4-fluorophenyl)-2-methoxyethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-ethyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrazin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2-methoxy-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridazin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methylpiperidin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[3-(methylsulfamoyl)pyridin-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxopiperidin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(2-cyclopropylpropan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-methyl-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[-2-methyl-1-phenylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2,2,2-trifluoro-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyrazin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridazin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-cyanophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'RS)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{1-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]ethyl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-5-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(2-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(4-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]methyl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrimidin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluoropyridin-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrimidin-5-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-chloropyridin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-3-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-5-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'RS)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(35)-2,3-dihydro-1-benzofuran-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(bicyclo[1.1.1]pentan-1-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(1,2-oxazol-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorobicyclo[1.1.1]pentan-1-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(bicyclo[1.1.1]pentan-1-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorobicyclo[1.1.1]pentan-1-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(pyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of stereoisomer) 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide acetate (1:1) (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(propan-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(bicyclo[2.2.1]heptan-1-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-benzylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(4-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-methylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(trifluoromethyl)sulfanyl]pyridin-3-yl}-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3R)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-imidazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(pyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-cyanophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide [2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl](1H-imidazol-1-yl)methanone (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-methylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(3-methyloxetan-3-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (mixture of stereoisomer) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3,5-difluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(5-fluoropyridin-2-yl)-2-methylpropan-1-one (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclohexyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(5-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,2,2-trifluoro-1-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyrimidin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyrimidin-5-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(3-phenyloxetan-3-yl)methanone (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(3,5-difluorophenyl)-2-methylpropan-1-one (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-methyl-2-(6-methylpyridin-3-yl)propan-1-one (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(3-phenyloxetan-3-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chloro-5-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chloro-5-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(benzyloxy)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(pyridazin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) 2'-{6-amino-5-[(pyridazin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) (35)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) (35)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) (rac)-2'-(2-amino-1'-methyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoroacetyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-phenylethyl]sulfanyl}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-{6-amino-5-[(cyclohexylmethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(benzylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-cyclohexylethyl]sulfanyl}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(cyclopentylmethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-nitropyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(benzyloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-methylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-nitropyridin-3-yl)-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide methyl 2-amino-5-[(rac)-1-(ethylcarbamoyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridine-3-carboxylate (rac)-2'-(6-amino-5-phenylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(methylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(4-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-methoxypyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-fluorophenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(2-amino[3,3'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-fluorophenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2-[6-amino-5-(2-fluorophenyl)pyridin-3-yl]-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(2-methoxyphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(2-amino[3,4'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[3-(methanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(phenylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[5-(4-acetylphenyl)-6-aminopyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methanesulfinyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-methoxyphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(cyclopropanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(4-sulfamoylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methylsulfamoyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(dimethylsulfamoyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(cyclohexylmethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(4-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-phenylethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(propan-2-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyclopropylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(dimethylcarbamoyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1,2-thiazol-5-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(trifluoromethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-[1-methyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-[1-methyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) ((3R)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) (rac)-2'-[6-amino-5-(difluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-methylphenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1-methyl-1H-pyrazol-5-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1-methyl-1H-pyrazol-4-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1,5-dimethyl-1H-pyrazol-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(4-methylphenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(3-methylphenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(propan-2-yl)oxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1-methyl-1H-pyrazol-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{[1-(3,5-difluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) (3R)-2'-(6-amino-5-{[1-(3,5-difluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(15)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(phenylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(cyclohexylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(diethylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{1-[1-(1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1-methyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(4-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(3-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(4-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-[(3S)-1-(pyridin-3-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-3-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-[(35)-1-(1H-imidazol-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(1H-imidazol-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(4-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-pyrazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-imidazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-imidazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(4-chloro-1H-pyrazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 3-[(2-fluorophenyl)methoxy]-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 3-[(3-fluorophenyl)methoxy]-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1'-[(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-5-{1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridine-3-carbonitrile 5-{(rac)-1-[(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridine-3-carbonitrile 5-{1-[(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(5-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(2,4-dimethyl-1H-imidazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) 5-{(3R)-1-[(1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) 5-{(3R)-1-[1-(1-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 3-(trifluoromethyl)-5-[(3R)-1-{[4-(trifluoromethyl)-1H-imidazol-2-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridin-2-amine 2-amino-5-[(rac)-1-(ethylcarbamoyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridine-3-carboxylic acid 5-[(35)-1-(pyridin-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3S)-1-(pyridin-4-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-4-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[3-(dimethylamino)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[2-(dimethylamino)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (stereoisomer 2) 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (stereoisomer 1) 2-amino-1-{2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethan-1-one (stereoisomer 2) 2-amino-1-{2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethan-1-one (stereoisomer 1) 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (25)-2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propan-1-one (2R)-2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propan-1-one (rac)-2'-[6-amino-5-(1-methylpiperidin-4-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(rac)-1-[(5-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 5-{(3'R)-1'-[(1S)-1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(1R)-1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine 3-(difluoromethoxy)-5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 3-(difluoromethoxy)-5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 2-amino-5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (3R)-2'-(6-amino-5-{[1-(6-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(6-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(5-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(5-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(4-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(3-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(3-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(15)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-1H-pyrazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1S)-1-(3-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(15)-1-(4-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(15)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1 and enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1 and enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{methyl[(1R)-1-phenylethyl]amino}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl)(cyclopropyl)methanone 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-1,2,4-triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-1,2,4-triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-1,2,4-Triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 2) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1 and enantiomer 2) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 2) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2,2-dimethylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1 and enantiomer 2) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(35)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3S)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(35)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(35)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(35)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(35)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer2) {(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(1H-imidazol-2-yl)methanone {(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(1-methyl-1H-imidazol-2-yl)methanone 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-{(3R)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-chloropyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-methylpyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-methylpyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-methoxypyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclopropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(2-methoxyphenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 1 and diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 1) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 2) (3S)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) (3R)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-chlorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3R)-1-[1-(1H-pyrrol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-methoxypyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 1 and diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 1) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chloro-3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(methylsulfanyl)pyridin-4-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclopropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-methylpyridin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(6-methoxypyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(6-methoxypyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-(6-amino-5-{1-[3-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl]ethoxy}pyridin-3-yl)-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(1,3-oxazol-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3R)-1-[cyclopropyl(5-fluoropyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyrimidin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(4-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(dimethylamino)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,2-thiazol-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 6-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyridin-2(1H)-one (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (4 isomers) (3R)-2'-{6-amino-5-[1-(1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1,3-thiazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 6-({(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}methyl)pyridin-2(1H)-one (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(methylamino)ethan-1-one (2R)-1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(methylamino)propan-1-one (5R)-5-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyrrolidin-2-one 5-{(3R)-1-[(1,3,4-thiadiazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (55)-5-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyrrolidin-2-one 5-{(3'R)-1'-[1-(6-methoxypyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(6-methoxypyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(6-methoxypyridin-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(3-fluoropyridin-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 2) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 1) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 2) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1-propyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1,3-thiazol-4-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(pyrimidin-4-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(2,4-dimethylpyrimidin-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(2,4-dimethylpyrimidin-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1-methyl-1H-1,2,3-triazol-5-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{[1-(1-methyl-1H-1,2,3-triazol-4-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (55)-5-{[(3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl]methyl}pyrrolidin-2-one (5R)-5-{[(3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl]methyl}pyrrolidin-2-one (3R)-2'-(6-amino-5-{1-[4-(methylsulfonyl)phenyl]ethoxy}pyridin-3-yl)-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-methyl-1,3-thiazol-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-({1-[3-(methanesulfonyl)phenyl]ethyl}oxy)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4-methyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4,5-dimethyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(5-methyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 1) 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 2) 6-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(cyclopropyl)methyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 6-({(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}(cyclopropyl)methyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 1) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 2) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 3) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 4) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclohexyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclohexyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclobutyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-methylcyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diasteroemr 1 and diastereomer 2) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(4H-1,2,4-triazol-3-yl)(1- 2< H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diatereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1- 2< H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)( 2< H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(2-methoxypyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-[{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(cyclopropyl)methyl]pyridin-2(1H)-one (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(4-methoxypyrimidin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(1-fluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(pyrimidin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) (3R)-2'-{5-amino-6-[(1R)-1-phenylethoxy]pyrazin-2-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 2) or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment 10:

[0117] A compound of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 for the use as a medicament.Embodiment 11:

[0118] A compound of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 for use in the treatment or prophylaxis of a disease.Embodiment 12:

[0119] A pharmaceutical composition comprising a compound of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 and one or more pharmaceutically acceptable excipients.Embodiment 13:

[0120] A pharmaceutical combination comprising: one or more first active ingredients, in particular compounds of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 and one or more pharmaceutical active anti cancer compounds or one or more pharmaceutical active immune checkpoint inhibitors. Embodiment 14:

[0121] A pharmaceutical combination according to claim 10, characterized in that the pharmaceutical active immune checkpoint inhibitor is an antibody.Embodiment 15:

[0122] Use of a compound of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 for the treatment or prophylaxis of a disease.Embodiment 16:

[0123] Use of a compound of general formula (I) according to any one of embodiments 1, 2, 3, 4, 5, 6, 7, 8 or 9 for the preparation of a medicament for the treatment or prophylaxis of a disease.Embodiment 17:

[0124] Use according to embodiments 15 or 16, wherein the disease is cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, such as liquid and solid tumours.Embodiment 18:

[0125] Use according to embodiments 15 or 16, wherein the diseases, respectively the disorders are benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, neurodegenerative disorders, in inflammatory disorders, and male fertility control.

[0126] This invention also covers the following embodiments:Embodiment A'

[0127] Compounds of formula (I') wherein Ais selected from a single bond, -CH 2 - or -O-; Eis -(CH 2 ) n - with n = 1 or 2; Gis -(CH 2 ) m - with m = 1, 2 or 3 and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 6 membered heterocycloalkyl; R 1< is selected from -NO 2 ; -CN; C 1-4 -alkyl optionally substituted by -OH or 1 to 3 -F; 3 to 6 membered heterocycloalkyl with 1 - 2 nitrogen atoms; phenyl optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; 5 to 6 membered heteroaryl with 1 or 2 heteroatoms selected from N or S and optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; -O-CH 3 ; -O-CH(CH 3 ) 2 ; -O-CHF 2 ; -O-CF 3 ; -O-CHR a -phenyl optionally substituted by one or two halogen, -CN, C 1-4 -alkyl or -SO 2 -CH 3 and with R a selected from -H or -CH 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -O-CHR a -6 membered heteroaryl optionally substituted one or two halogen, -CN, C 1-4 -alkyl or -SO 2 -CH 3 and with R a selected from -H or -CH 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -COOR a with R a selected from -H or -CH 3 ; C(=O)-methyl, optionally substituted by 1 to 3 -F; -C(=O)-NR b R c wherein R b is selected from -H, -CH 3 or -CH 2 -CH 3 and wherein R c is selected from -H, -CH 3 , -CH 2 -CH 3 ; -S-CR f R g R h , wherein R f is selected from -H or -F, wherein R g is selected from -H, -F or -CH 3 and wherein R h is selected from C 5-6 -cycloalkyl or phenyl; R 2< is selected from -H, -CH 3 or -F; or R 4< is selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -OR i wherein R i is selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ∘ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl or ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-R l in which R l is selected from ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment A"

[0128] Compounds of formula (I") wherein Ais selected from a single bond, -CH 2 - or -O-; Eis -(CH 2 ) n - with n = 1 or 2; Gis -(CH 2 )- and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 5 membered heterocycloalkyl; R 1< is selected from -NO 2 ; -CN; C 1-4 -alkyl optionally substituted by -OH or 1 to 3 -F; cyclopropyl; 4 to 6 membered heterocycloalkyl or heterocycloalkenyl, both with 1 - 2 nitrogen atoms, but always linked via a carbon atom to the phenyl group of compounds of formula (I) and both optionally substituted by C 1-4 -alkyl; phenyl optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -C(O)-R d , SR d , SOR d , SO 2 R d , SONR d , SON(H)R d , -SO 2 -NH 2 , - SO 2 -N(H)-R d or -SO 2 -N(R d ) 2 , wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; 5 to 6 membered heteroaryl with 1 or 2 heteroatoms selected from N or S and optionally substituted by halogen, -CN, C 1-4 -alkyl, C 1-4 -haloalkyl, C 3-6 -cycloalkyl, O-C 1-4 -alkyl, O-C 3-6 -cycloalkyl, C 1-3 -alkinyl, SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; -O-CH 3 ; -O-CH(CH 3 ) 2 ; -O-CHF 2 ; -O-CF 3 ; -O-CHR a -phenyl optionally substituted by one or two halogen, -CN, C 1-4 -alkyl or -SO 2 -CH 3 and with R a selected from -H or -CH 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -O-CHR a -6 membered heteroaryl optionally substituted one or two halogen, -CN, C 1-4 -alkyl or -SO 2 -CH 3 and with R a selected from -H or -CH 3 , -CH 2 -CH 3 , -CH(CH 3 ) 2 or -cyclopropyl; -COOR a with R a selected from -H or -CH 3 ; C(=O)-methyl, optionally substituted by 1 to 3 -F; -C(=O)-NR b R c wherein R b is selected from -H, -CH 3 or -CH 2 -CH 3 and wherein R c is selected from -H, -CH 3 , -CH 2 -CH 3 , cyclohexyl, phenyl or 5 to 6 membered heteroaryl, all optionally substituted by one or two halogen, -CN, -SO 2 -CH 3 or C 1-4 -alkyl, optionally substituted one or more times with halogen; -S-CR f R g R h , wherein R f is selected from -H or -F, wherein R g is selected from -H, -F or -CH 3 and wherein R h is selected from H, F, -CH 3 or C 5-6 -cycloalkyl or phenyl; R 2< is selected from -H; or R 4< is selected from C 1-5 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or independently more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -OR i wherein R i is selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), ∘ -CF 3 , -CHF 2 , -CH 2 F, or -CH 2 -CF 3 ; ∘ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl, ∘ -CH 2 -O-CH 3 or ∘ C 3-4 cycloalkyl or 4 membered heterocycloalkyl, both optionally substituted by -F or - CH 3 ; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-R l in which R l is selected from ∘ C 1-4 -alkyl, C 3-6 -cycloalkyl or C 3-6 -heterocycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-NR o R p wherein R o and R p are independently selected from o H o C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF 3 , -CHF 2 , -CH 2 F, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment B

[0129] Of selected interest are compounds of formulas (I), (Ia), (I') or (I") (see embodiments 1, A, A' and A"), wherein R 4 is and R q is selected from H, -CH 3 ,-CH 2 -CH 3 , -CH(CH 3 ) 2 , -CH 2 -O-CH 3 , - CF 3 , -CHF 2 , -CH 2 F, -CH 2 -CF 3 , cyclopropyl or cyclobutyl or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Emboyment C

[0130] Of selected interest are compounds of formulas (I), (Ia), (I') or (I"), wherein R 4 is selected from C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 -cycloalkyl, -CF 3 , -CHF 2 , -CH 2 F; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF 3 , -CHF 2 , -CH 2 F, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment C

[0131] Of selected interest are compounds of formulas (I), (Ia), (I') or (I") (see embodiments 1, A, A' and A"), wherein A is selected from a single bond or -O- or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment D

[0132] Of selected interest are compounds of formulas (I), (Ia), (I') or (I") (see embodiments 1, A, A' and A"), wherein E is -CH 2 -CH 2 - or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

[0133] Of selected interest are also the following groups of compounds:Embodiment E

[0134] The compound of formula (I-1) wherein R 1< is selected from the group consisting of R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 4< is selected from the group consisting of C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -OR i wherein R i is selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ∘ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl or ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-R l in which R l is selected from ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; C(=O)-NR o R p wherein R o and R p are independently selected from ∘ H ∘ C 1-4 -alkyl or C 3-6 -cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -OR i with R i selected from C 1-4 -alkyl or C 3-6 Cycloalkyl), -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3; ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by halogen, -CN, -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, C 1 - 4 -alkyl optionally substituted with one or more halogen; C 3-6 -cycloalkyl; O-C 1-4 -alkyl, O-C 3-6 -cycloalky, C 1-3 -alkinyl, -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF x H y with x and y = 0, 1, 2 or 3 and x + y = 3, ▪ C 1 - 4 -alkyl optionally substituted with one or more halogen; ▪ C 3-6 -cycloalkyl; ▪ O-C 1-4 -alkyl, ▪ O-C 3-6 -cycloalky, ▪ C 1-3 -alkinyl, ▪ -NR j R k wherein R j and R k are independently selected from -H and C 1 -C 4 -alkyl ▪ SR d , SOR d , SO 2 R d , SONR d or SON(H)R d wherein R d is selected from methyl, ethyl, cyclopropyl, isopropyl and tert. butyl; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and - N-CH 2 -, -O-CH 2 -, and -S-CH 2 -; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment F

[0135] Compound according to embodiment E wherein R 1< is selected from the group consisting of R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 4< is selected from the group consisting of -CONHR 13< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 5< is selected from the group consisting of -COOC(R 17< )(R 18< ) 2 , -C(=R 21< )NHC(R 18< )(R 19< )R 20< , R 7< is selected from the group consisting of -CONHR 28< and -COOC(CH 3 ) 3 ; R 8< is selected from the group consisting of -CONHR 29< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 9< is selected from the group consisting of -CONHR 30< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 13< is selected from the group consisting of -CH 2 CH 3 , -C(CH 3 ) 2 R 47< , bicyclo[2.2.1]heptan-1-yl, (pyrimidin-4-yl)methyl, 1-(1,2-oxazol-3-yl)ethyl, 1-(5-fluoropyridin-3-yl)ethyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 14< is selected from the group consisting of R 15< is selected from the group consisting of -CH 2 - and -CHCH 3 NHCO-; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 17< is selected from the group consisting of -CH 3 and phenyl; R 18< is selected from the group consisting of -H and -CH 3 ; R 19< is selected from the group consisting of -CH 3 , cyclopropyl, 1,2-oxazol-3-yl, pyridazin-3-yl, pyridazin-4-yl, oxan-4-yl, 1-methyl-1H-1,2,3-triazol-4-yl, 1-methylpiperidin-4-yl, 1,3,4-trimethyl-1H-pyrazol-5-yl, 1-methyl-2-oxopiperidin-4-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, R 20< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , -CH(CH 3 ) 2 , and -CH 2 OCH 3 ; R 21< is selected from the group consisting of =O and =NCN; R 22< is selected from the group consisting of -H, pyridin-4-yl, pyridin-3-yl, R 23< is selected from the group consisting of -C(CH 3 ) 2 CO- and -CH(R 18< )NHCO-; R 21< is selected from the group consisting of -NHCO-, -C(CH 3 ) 2 CO-, -C(R 59< )(R 60< )NHCO-, R 25< is selected from the group consisting of -H, -F, -Cl, -CN, and -SO 2 NHCH 3 ; R 26< is selected from the group consisting of -H, -F, -CN, and -CF 3 ; R 27< is selected from the group consisting of -H and -F; R 28< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , and cyclobutyl; R 29< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , cyclobutyl, and R 30< is selected from the group consisting of -CH 2 CH 3 , cyclobutyl, -C(CH 3 ) 2 R 63< , 1-(5-fluoropyridin-3-yl)ethyl, R 31< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 36< is selected from the group consisting of -H, -F, and -CN; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and - N-CH 2 -, -O-CH 2 -, and -S-CH 2 -; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 47< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, R 48< is selected from the group consisting of -H, -CH 3 , -CH(CH 3 ) 2 , and pyridin-4-yl; R 49< is selected from the group consisting of -CH 2 - and -CH 2 O-; R 50< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, and R 51< is selected from the group consisting of -H, -CH 3 , and -CN; R 52< is selected from the group consisting of -H, -CH 3 , and -CHF 2 ; R 53< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, R 54< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , and -CH 2 OCH 3 ; R 55< is selected from the group consisting of -CH 2 - and -OCH 2 -; R 56< is selected from the group consisting of -CH 3 and -CF 3 ; R 57< is selected from the group consisting of -H, -CH 3 , -F, and -CN; R 58< is selected from the group consisting of -H, -CH 3 , and -CF 3 ; R 59< is selected from the group consisting of -H, -CH 3 , cyclopropyl, -CH 2 OCH 3 , and -CF 3 ; R 60< is selected from the group consisting of -H, -CH 3 , and -OCH 3 ; R 61< is selected from the group consisting of -NH- and -NHCH 2 -; R 62< is selected from the group consisting of -CH 2 - and R 63< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, and 3-chloropyridin-4-yl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment G

[0136] The compound according to embodiment E wherein R 1< is selected from or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment H

[0137] The compound according to embodiment E wherein R 1< is selected from or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodyment I

[0138] The compound according to embodiment E wherein R 1< is selected from the group consisting of or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment J

[0139] The compound according to embodiment F wherein R 1< is selected from or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment K

[0140] The compound according to embodiment F wherein R 1< is selected from or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.Embodiment L

[0141] The compound according to embodiment F wherein R 1< is selected from or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. and their polymorphs, enantiomers, diastereomers, racemates, tautomers, solvates, physiologically acceptable salts and solvates of these salts.Embodiment M

[0142] Compound of formula (I-2) wherein R 1< is selected from the group consisting of R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 4< is selected from the group consisting of -CONHR 13< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 3< is selected from the group consisting of -COOC(R 17< )(R 18< ) 2 , -C(=R 21< )NHC(R 18< )(R 19< )R 20< , R 7< is selected from the group consisting of -CONHR 28< and -COOC(CH 3 ) 3 ; R 3< is selected from the group consisting of -CONHR 29< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 9< is selected from the group consisting of -CONHR 30< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 10< is selected from the group consisting of -CH 2 CH 3 , {1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl}methyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 13< is selected from the group consisting of -CH 2 CH 3 , -C(CH 3 ) 2 R 47< , bicyclo[2.2.1]heptan-1-yl, (pyrimidin-4-yl)methyl, 1-(1,2-oxazol-3-yl)ethyl, 1-(5-fluoropyridin-3-yl)ethyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 14< is selected from the group consisting of R 15< is selected from the group consisting of -CH 2 - and -CHCH 3 NHCO-; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 17< is selected from the group consisting of -CH 3 and phenyl; R 18< is selected from the group consisting of -H and -CH 3 ; R 19< is selected from the group consisting of -CH 3 , cyclopropyl, 1,2-oxazol-3-yl, pyridazin-3-yl, pyridazin-4-yl, oxan-4-yl, 1-methyl-1H-1,2,3-triazol-4-yl, 1-methylpiperidin-4-yl, 1,3,4-trimethyl-1H-pyrazol-5-yl, 1-methyl-2-oxopiperidin-4-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, R 20< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , -CH(CH 3 ) 2 , and -CH 2 OCH 3 ; R 21< is selected from the group consisting of =O and =NCN; R 22< is selected from the group consisting of -H, pyridin-4-yl, pyridin-3-yl, R 23< is selected from the group consisting of -C(CH 3 ) 2 CO- and -CH(R 18< )NHCO-; R 21< is selected from the group consisting of -NHCO-, -C(CH 3 ) 2 CO-, -C(R 59< )(R 60< )NHCO-, R 25< is selected from the group consisting of -H, -F, -Cl, -CN, and -SO 2 NHCH 3 ; R 26< is selected from the group consisting of -H, -F, -CN, and -CF 3 ; R 27< is selected from the group consisting of -H and -F; R 28< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , and cyclobutyl; R 29< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , cyclobutyl, and R 30< is selected from the group consisting of -CH 2 CH 3 , cyclobutyl, -C(CH 3 ) 2 R 63< , 1-(5-fluoropyridin-3-yl)ethyl, R 31< is selected from the group consisting of -CHCH 3 - and R 32< is selected from the group consisting of -H and -CN; R 33< is selected from the group consisting of -CHCH 3 -, -C(CH 3 ) 2 -, and R 34< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 36< is selected from the group consisting of -H, -F, and -CN; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 47< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, R 48< is selected from the group consisting of -H, -CH 3 , -CH(CH 3 ) 2 , and pyridin-4-yl; R 49< is selected from the group consisting of -CH 2 - and -CH 2 O-; R 50< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, and R 51< is selected from the group consisting of -H, -CH 3 , and -CN; R 52< is selected from the group consisting of -H, -CH 3 , and -CHF 2 ; R 53< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, R 54< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , and -CH 2 OCH 3 ; R 55< is selected from the group consisting of -CH 2 - and -OCH 2 -; R 56< is selected from the group consisting of -CH 3 and -CF 3 ; R 57< is selected from the group consisting of -H, -CH 3 , -F, and -CN; R 58< is selected from the group consisting of -H, -CH 3 , and -CF 3 ; R 59< is selected from the group consisting of -H, -CH 3 , cyclopropyl, -CH 2 OCH 3 , and -CF 3 ; R 60< is selected from the group consisting of -H, -CH 3 , and -OCH 3 ; R 61< is selected from the group consisting of -NH- and -NHCH 2 -; R 62< is selected from the group consisting of -CH 2 - and R 63< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, and 3-chloropyridin-4-yl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment N

[0143] A compound according to embodiment M of formula (I-3) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 4< is selected from the group consisting of -CONHR 13< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 13< is selected from the group consisting of -CH 2 CH 3 , -C(CH 3 ) 2 R 47< , bicyclo[2.2.1]heptan-1-yl, (pyrimidin-4-yl)methyl, 1-(1,2-oxazol-3-yl)ethyl, 1-(5-fluoropyridin-3-yl)ethyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 34< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 47< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, R 48< is selected from the group consisting of -H, -CH 3 , -CH(CH 3 ) 2 , and pyridin-4-yl; R 49< is selected from the group consisting of -CH 2 - and -CH 2 O-; R 50< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, and R 51< is selected from the group consisting of -H, -CH 3 , and -CN; R 52< is selected from the group consisting of -H, -CH 3 , and -CHF 2 ; R 53< is selected from the group consisting of -CH 2 -, -CHCH 3 -, -C(CH 3 ) 2 -, R 54< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , and -CH 2 OCH 3 ; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment O

[0144] Compound according to embodiment M of formula (I-4) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 3< is selected from the group consisting of -COOC(R 17< )(R 18< ) 2 , -C(=R 21< )NHC(R 18< )(R 19< )R 20< , R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 14< is selected from the group consisting of R 15< is selected from the group consisting of -CH 2 - and -CHCH 3 NHCO-; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 17< is selected from the group consisting of -CH 3 and phenyl; R 18< is selected from the group consisting of -H and -CH 3 ; R 19< is selected from the group consisting of -CH 3 , cyclopropyl, 1,2-oxazol-3-yl, pyridazin-3-yl, pyridazin-4-yl, oxan-4-yl, 1-methyl-1H-1,2,3-triazol-4-yl, 1-methylpiperidin-4-yl, 1,3,4-trimethyl-1H-pyrazol-5-yl, 1-methyl-2-oxopiperidin-4-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, R 20< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , -CH(CH 3 ) 2 , and -CH 2 OCH 3 ; R 21< is selected from the group consisting of =O and =NCN; R 22< is selected from the group consisting of -H, pyridin-4-yl, pyridin-3-yl, R 23< is selected from the group consisting of -C(CH 3 ) 2 CO- and -CH(R 18< )NHCO-; R 24< is selected from the group consisting of -NHCO-, -C(CH 3 ) 2 CO-, -C(R 59< )(R 60< )NHCO-, R 25< is selected from the group consisting of -H, -F, -Cl, -CN, and -SO 2 NHCH 3 ; R 26< is selected from the group consisting of -H, -F, -CN, and -CF 3 ; R 27< is selected from the group consisting of -H and -F; R 34< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 36< is selected from the group consisting of -H, -F, and -CN; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 55< is selected from the group consisting of -CH 2 - and -OCH 2 -; R 56< is selected from the group consisting of -CH 3 and -CF 3 ; R 57< is selected from the group consisting of -H, -CH 3 , -F, and -CN; R 58< is selected from the group consisting of -H, -CH 3 , and -CF 3 ; R 59< is selected from the group consisting of -H, -CH 3 , cyclopropyl, -CH 2 OCH 3 , and -CF 3 ; R 60< is selected from the group consisting of -H, -CH 3 , and -OCH 3 ; R 61< is selected from the group consisting of -NH- and -NHCH 2 -; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment P

[0145] A compound according to embodiment M of formula (I-5) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 7< is selected from the group consisting of -CONHR 28< and -COOC(CH 3 ) 3 ; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 28< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , and cyclobutyl; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodyment Q

[0146] A compound according to embodiment M of formula (I-6) R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 3< is selected from the group consisting of -CONHR 29< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 29< is selected from the group consisting of -CH 2 CH 3 , -CH(CH 3 ) 2 , cyclobutyl, and R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 62< is selected from the group consisting of -CH 2 - and R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment R

[0147] A compound according to embodiment M of formula (I-7) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 9< is selected from the group consisting of -CONHR 30< , (1H-imidazol-2-yl)methyl, and -COOC(CH 3 ) 3 ; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 30< is selected from the group consisting of -CH 2 CH 3 , cyclobutyl, -C(CH 3 ) 2 R 63< , 1-(5-fluoropyridin-3-yl)ethyl, R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 54< is selected from the group consisting of -H, -CH 3 , -CH 2 CH 3 , and -CH 2 OCH 3 ; R 63< is selected from the group consisting of -H, 1-methyl-1H-1,2,3-triazol-4-yl, and 3-chloropyridin-4-yl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment S

[0148] A compound according to embodiment M of formula (I-8) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 10< is selected from the group consisting of -CH 2 CH 3 , {1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl}methyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 31< is selected from the group consisting of -CHCH 3 - and R 32< is selected from the group consisting of -H and -CN; R 33< is selected from the group consisting of -CHCH 3 -, -C(CH 3 ) 2 -, and R 34< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 36< is selected from the group consisting of -H, -F, and -CN; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodiment T

[0149] A compound according to embodyment M of formula (I-9) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 10< is selected from the group consisting of -CH 2 CH 3 , {1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl}methyl, 1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl, R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 31< is selected from the group consisting of -CHCH 3 - and R 32< is selected from the group consisting of -H and -CN; R 33< is selected from the group consisting of -CHCH 3 -, -C(CH 3 ) 2 -, and R 34< is selected from the group consisting of -H, -F, -CI, and -CN; R 35< is selected from the group consisting of -CH 3 and -CH 2 CH 3 ; R 36< is selected from the group consisting of -H, -F, and -CN; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. Embodyment U

[0150] A compound according to embodyment M of formula (I-10) wherein R 2< is selected from the group consisting of 4-amino-1H-imidazo[4,5-c]pyridin-7-yl, 6-amino-5-cyclohexylmethanesulfonyl-1-oxidopyridin-1-ium-3-yl, and R 3< is selected from the group consisting of -H, -Cl, and -Br; R 11< is selected from the group consisting of -H, -CH 3 , -F, -Cl, -Br, -CN, -OCH 3 , -CH 2 OH, -SCH 3 , cyclopropyl, -NO 2 , -NHCCH 3 O, -P(CH 3 ) 2 O, -C(CH 3 ) 2 R 37< , -COOR 18< , -CF 2 R 38< , -SO 2 R 39< , -SC(CH 3 ) 3 , 1,2-thiazol-5-yl, -SCF 3 , -OCF 2 R 27< , pyridin-4-yl, 1-methyl-1H-pyrazol-3-yl, -CON(R 16< )CH 2 R 18< , -COC(R 27< ) 3 , 1-methylpiperidin-4-yl, 1-methyl-1,2,3,6-tetrahydropyridin-4-yl, 1,5-dimethyl-1H-pyrazol-4-yl, (cyclopentylmethyl)sulfanyl, 1-(pyridin-4-yl)ethoxy, 5H,6H,7H-cyclopenta[b]pyridin-7-yloxy, R 12< is selected from the group consisting of -H, -CH 3 , -F, and -CF 3 ; R 16< is selected from the group consisting of -H, -CH 3 , and -CH 2 CH 3 ; R 18< is selected from the group consisting of -H and -CH 3 ; R 27< is selected from the group consisting of -H and -F; R 37< is selected from the group consisting of -H and -OH; R 38< is selected from the group consisting of -H, -CH 3 , and -F; R 39< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , morpholin-4-yl, and 4-methylpiperazin-1-yl; R 40< is selected from the group consisting of -NHCO-, -CHCH 3 S-, -CH 2 SO-, -CH 2 SO 2 -, and **-N-CH 2 -*, **-O-CH 2 -*, and **-S-CH 2 -*; R 41< is selected from the group consisting of -CH 2 S-, -SO-, -NHCO-, -CHCH 3 S-, -O-, and -S-; R 42< is selected from the group consisting of -CH 2 O-, -CHCH 3 O-, and -CHCH 3 NHCO-; R 43< is selected from the group consisting of -H and -Cl; R 44< is selected from the group consisting of -H, -CH 3 , -CCH 3 O, -SCH 3 O, -SO 2 R 64< , and dimethoxyphosphoryl; R 45< is selected from the group consisting of -H, -CH 3 , -F, -OCH 3 , and -SCH 3 O 2 ; R 46< is selected from the group consisting of -H, -F, and -Cl; R 64< is selected from the group consisting of -CH 3 , -NH 2 , -NHCH 3 , cyclopropyl, and -N(CH 3 ) 2 ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

[0151] The compounds of general formula (I) of the present invention can be converted to any salt, preferably pharmaceutically acceptable salts, as described herein, by any method which is known to the person skilled in the art. Similarly, any salt of a compound of general formula (I) of the present invention can be converted into the free compound, by any method which is known to the person skilled in the art.

[0152] Compounds of general formula (I) of the present invention demonstrate a valuable pharmacological spectrum of action, which could not have been predicted. Compounds of the present invention have surprisingly been found to effectively inhibit MAP4K1 and it is possible therefore that said compounds be used for the treatment or prophylaxis of diseases, preferably cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, in humans and animals.

[0153] Disorders and conditions particularly suitable for treatment with an MAP4K1 inhibitor of the present invention are liquid and solid tumours, such as cancers of the breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, skin, head and neck, thyroid, parathyroid and their distant metastases. Those disorders also include lymphomas, sarcomas, and leukaemias.

[0154] Examples of breast cancers include, but are not limited to, triple negative breast cancer, invasive ductal carcinoma, invasive lobular carcinoma, ductal carcinoma in situ, and lobular carcinoma in situ. Examples of cancers of the respiratory tract include, but are not limited to, small-cell and non-small-cell lung carcinoma, as well as bronchial adenoma and pleuropulmonary blastoma.

[0155] Examples of brain cancers include, but are not limited to, brain stem and hypophtalmic glioma, cerebellar and cerebral astrocytoma, glioblastoma, medulloblastoma, ependymoma, as well as neuroectodermal and pineal tumour.

[0156] Tumours of the male reproductive organs include, but are not limited to, prostate and testicular cancer.

[0157] Tumours of the female reproductive organs include, but are not limited to, endometrial, cervical, ovarian, vaginal, and vulvar cancer, as well as sarcoma of the uterus.

[0158] Examples of ovarian cancer include, but are not limited to serous tumour, endometrioid tumour, mucinous cystadenocarcinoma, granulosa cell tumour, Sertoli-Leydig cell tumour and arrhenoblastoma.

[0159] Examples of cervical cancer include, but are not limited to squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, small cell carcinoma, neuroendocrine tumour, glassy cell carcinoma and villoglandular adenocarcinoma.

[0160] Tumours of the digestive tract include, but are not limited to, anal, colon, colorectal, esophageal, gallbladder, gastric, pancreatic, rectal, small-intestine, and salivary gland cancers.

[0161] Examples of esophageal cancer include, but are not limited to esophageal cell carcinomas and adenocarcinomas, as well as squamous cell carcinomas, leiomyosarcoma, malignant melanoma, rhabdomyosarcoma and lymphoma.

[0162] Examples of gastric cancer include, but are not limited to intestinal type and diffuse type gastric adenocarcinoma.

[0163] Examples of pancreatic cancer include, but are not limited to ductal adenocarcinoma, adenosquamous carcinomas and pancreatic endocrine tumours.

[0164] Tumours of the urinary tract include, but are not limited to, bladder, penile, kidney, renal pelvis, ureter, urethral and human papillary renal cancers.

[0165] Examples of kidney cancer include, but are not limited to renal cell carcinoma, urothelial cell carcinoma, juxtaglomerular cell tumour (reninoma), angiomyolipoma, renal oncocytoma, Bellini duct carcinoma, clear-cell sarcoma of the kidney, mesoblastic nephroma and Wilms' tumour.

[0166] Examples of bladder cancer include, but are not limited to transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, sarcoma and small cell carcinoma.

[0167] Eye cancers include, but are not limited to, intraocular melanoma and retinoblastoma.

[0168] Examples of liver cancers include, but are not limited to, hepatocellular carcinoma (liver cell carcinomas with or without fibrolamellar variant), cholangiocarcinoma (intrahepatic bile duct carcinoma), and mixed hepatocellular cholangiocarcinoma.

[0169] Skin cancers include, but are not limited to, squamous cell carcinoma, Kaposi's sarcoma, malignant melanoma, Merkel cell skin cancer, and non-melanoma skin cancer.

[0170] Head-and-neck cancers include, but are not limited to, squamous cell cancer of the head and neck, laryngeal, hypopharyngeal, nasopharyngeal, oropharyngeal cancer, salivary gland cancer, lip and oral cavity cancer and squamous cell.

[0171] Lymphomas include, but are not limited to, AIDS-related lymphoma, non-Hodgkin's lymphoma, cutaneous T-cell lymphoma, Burkitt lymphoma, Hodgkin's disease, and lymphoma of the central nervous system.

[0172] Sarcomas include, but are not limited to, sarcoma of the soft tissue, osteosarcoma, malignant fibrous histiocytoma, lymphosarcoma, and rhabdomyosarcoma.

[0173] Leukemias include, but are not limited to, acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, chronic myelogenous leukemia, and hairy cell leukemia.

[0174] The term "treating" or "treatment" as stated throughout this document is used conventionally, for example the management or care of a subject for the purpose of combating, alleviating, reducing, relieving, improving the condition of a disease or disorder, such as a carcinoma.

[0175] The compounds of the present invention can be used in particular in therapy and prevention, i.e. prophylaxis, of tumour growth and metastases, especially in solid tumours of all indications and stages with or without pre-treatment of the tumour growth.

[0176] Generally, the use of chemotherapeutic agents and / or anti-cancer agents in combination with a compound or pharmaceutical composition of the present invention will serve to: 1. yield better efficacy in reducing the growth of a tumour or even eliminate the tumour as compared to administration of either agent alone, 2. provide for the administration of lesser amounts of the administered chemotherapeutic agents, 3. provide for a chemotherapeutic treatment that is well tolerated in the patient with fewer deleterious pharmacological complications than observed with single agent chemotherapies and certain other combined therapies, 4. provide for treating a broader spectrum of different cancer types in mammals, especially humans, 5. provide for a higher response rate among treated patients, 6. provide for a longer survival time among treated patients compared to standard chemotherapy treatments, 7. provide a longer time for tumour progression, and / or 8. yield efficacy and tolerability results at least as good as those of the agents used alone, compared to known instances where other cancer agent combinations produce antagonistic effects.

[0177] In addition, the compounds of general formula (I) of the present invention can also be used in combination with radiotherapy and / or surgical intervention.

[0178] In a further embodiment of the present invention, the compounds of general formula (I) of the present invention are used in combination with radiation: i.e. radiation treatment sensitizes cancers to anti-tumor immune responses by induction of tumor cell death and subsequent presentation of tumor neoantigens to tumor-reactive Tcells. As MAP4K1 inhibition is enhancing the antigen specific activation of T cells, the overall effect results in a much stronger cancer cell attack as compared to irradiation treatment alone.

[0179] Thus, the present invention also provides a method of killing a tumor, wherein conventional radiation therapy is employed previous to administering one or more of the compounds of the present invention.

[0180] The compounds of the present invention can be administered as the sole pharmaceutical agent or in combination with one or more other pharmaceutically active ingredients where the combination causes no unacceptable adverse effects. The present invention also covers such pharmaceutical combinations. For example, the compounds of the present invention can be combined with: 131< I-chTNT, abarelix, abiraterone, aclarubicin, adalimumab, ado-trastuzumab emtansine, afatinib, aflibercept, aldesleukin, alectinib, alemtuzumab, alendronic acid, alitretinoin, alpharain, altretamine, amifostine, aminoglutethimide, hexyl aminolevulinate, amrubicin, amsacrine, anastrozole, ancestim, anethole dithiolethione, anetumab ravtansine, angiotensin II, antithrombin III, aprepitant, arcitumomab, arglabin, arsenic trioxide, asparaginase, atezolizumab, axitinib, azacitidine, basiliximab, belotecan, bendamustine, besilesomab, belinostat, bevacizumab, bexarotene, bicalutamide, bisantrene, bleomycin, blinatumomab, bortezomib, buserelin, bosutinib, brentuximab vedotin, busulfan, cabazitaxel, cabozantinib, calcitonine, calcium folinate, calcium levofolinate, capecitabine, capromab, carbamazepine carboplatin, carboquone, carfilzomib, carmofur, carmustine, catumaxomab, celecoxib, celmoleukin, cemiplimab, ceritinib, cetuximab, chlorambucil, chlormadinone, chlormethine, cidofovir, cinacalcet, cisplatin, cladribine, clodronic acid, clofarabine, cobimetinib, copanlisib , crisantaspase, crizotinib, cyclophosphamide, cyproterone, cytarabine, dacarbazine, dactinomycin, daratumumab, darbepoetin alfa, darolutamide, dabrafenib, dasatinib, daunorubicin, decitabine, degarelix, denileukin diftitox, denosumab, depreotide, deslorelin, dianhydrogalactitol, dexrazoxane, dibrospidium chloride, dianhydrogalactitol, diclofenac, dinutuximab, docetaxel, dolasetron, doxifluridine, doxorubicin, doxorubicin + estrone, dronabinol, eculizumab, edrecolomab, elliptinium acetate, elotuzumab, eltrombopag, endostatin, enocitabine, enzalutamide, epirubicin, epitiostanol, epoetin alfa, epoetin beta, epoetin zeta, eptaplatin, eribulin, erlotinib, esomeprazole, estradiol, estramustine, ethinylestradiol, etoposide, everolimus, exemestane, fadrozole, fentanyl, filgrastim, fluoxymesterone, floxuridine, fludarabine, fluorouracil, flutamide, folinic acid, formestane, fosaprepitant, fotemustine, fulvestrant, gadobutrol, gadoteridol, gadoteric acid meglumine, gadoversetamide, gadoxetic acid, gallium nitrate, ganirelix, gefitinib, gemcitabine, gemtuzumab, Glucarpidase, glutoxim, GM-CSF, goserelin, granisetron, granulocyte colony stimulating factor, histamine dihydrochloride, histrelin, hydroxycarbamide, I-125 seeds, lansoprazole, ibandronic acid, ibritumomab tiuxetan, ibrutinib, idarubicin, ifosfamide, imatinib, imiquimod, improsulfan, indisetron, incadronic acid, ingenol mebutate, interferon alfa, interferon beta, interferon gamma, iobitridol, iobenguane ( 123< I), iomeprol, ipilimumab, irinotecan, Itraconazole, ixabepilone, ixazomib, lanreotide, lansoprazole, lapatinib, larotrectinib, lasocholine, lenalidomide, lenvatinib, lenograstim, lentinan, letrozole, leuprorelin, levamisole, levonorgestrel, levothyroxine sodium, lisuride, lobaplatin, lomustine, lonidamine, masoprocol, medroxyprogesterone, megestrol, melarsoprol, melphalan, mepitiostane, mercaptopurine, mesna, methadone, methotrexate, methoxsalen, methylaminolevulinate, methylprednisolone, methyltestosterone, metirosine, mifamurtide, miltefosine, miriplatin, mitobronitol, mitoguazone, mitolactol, mitomycin, mitotane, mitoxantrone, mogamulizumab, molgramostim, mopidamol, morphine hydrochloride, morphine sulfate, nabilone, nabiximols, nafarelin, naloxone + pentazocine, naltrexone, nartograstim, necitumumab, nedaplatin, nelarabine, neridronic acid, netupitant / palonosetron, nivolumab, pentetreotide, nilotinib, nilutamide, nimorazole, nimotuzumab, nimustine, nintedanib, nitracrine, nivolumab, obinutuzumab, octreotide, ofatumumab, olaparib, olaratumab, omacetaxine mepesuccinate, omeprazole, ondansetron, oprelvekin, orgotein, orilotimod, osimertinib, oxaliplatin, oxycodone, oxymetholone, ozogamicine, p53 gene therapy, paclitaxel, palbociclib, palifermin, palladium-103 seed, palonosetron, pamidronic acid, panitumumab, panobinostat, pantoprazole, pazopanib, pegaspargase, PEG-epoetin beta (methoxy PEG-epoetin beta), pembrolizumab, pegfilgrastim, peginterferon alfa-2b, pembrolizumab, pemetrexed, pentazocine, pentostatin, peplomycin, Perflubutane, perfosfamide, Pertuzumab, picibanil, pilocarpine, pirarubicin, pixantrone, plerixafor, plicamycin, poliglusam, polyestradiol phosphate, polyvinylpyrrolidone + sodium hyaluronate, polysaccharide-K, pomalidomide, ponatinib, porfimer sodium, pralatrexate, prednimustine, prednisone, procarbazine, procodazole, propranolol, quinagolide, rabeprazole, racotumomab, radium-223 chloride, radotinib, raloxifene, raltitrexed, ramosetron, ramucirumab, ranimustine, rasburicase, razoxane, refametinib , regorafenib, risedronic acid, rhenium-186 etidronate, rituximab, rogaratinib, rolapitant, romidepsin, romiplostim, romurtide, roniciclib , samarium ( 153< Sm) lexidronam, sargramostim, satumomab, secretin, siltuximab, sipuleucel-T, sizofiran, sobuzoxane, sodium glycididazole, sonidegib, sorafenib, stanozolol, streptozocin, sunitinib, talaporfin, talimogene laherparepvec, tamibarotene, tamoxifen, tapentadol, tasonermin, teceleukin, technetium ( 99m< Tc) nofetumomab merpentan, 99m< Tc-HYNIC-[Tyr3]-octreotide, tegafur, tegafur + gimeracil + oteracil, temoporfin, temozolomide, temsirolimus, teniposide, testosterone, tetrofosmin, thalidomide, thiotepa, thymalfasin, thyrotropin alfa, tioguanine, tisagenlecleucel, tislelizumab, tocilizumab, topotecan, toremifene, tositumomab, trabectedin, trametinib, tramadol, trastuzumab, trastuzumab emtansine, treosulfan, tretinoin, trifluridine + tipiracil, trilostane, triptorelin, trametinib, trofosfamide, thrombopoietin, tryptophan, ubenimex, valatinib , valrubicin, vandetanib, vapreotide, vemurafenib, vinblastine, vincristine, vindesine, vinflunine, vinorelbine, vismodegib, vorinostat, vorozole, yttrium-90 glass microspheres, zinostatin, zinostatin stimalamer, zoledronic acid, zorubicin.

[0181] The compounds of the invention can further be combined with other reagents targeting the immune system, such as immune checkpoint inhibitors, e.g. aPD-1 / -L1 axis antagonists. PD-1, along with its ligands PD-L1 and PD-L2, function as negative regulators of T cell activation. MAP4K1 suppresses immune cell function. PD-L1 is overexpressed in many cancers and overexpression of PD-1 often occurs concomitantly in tumor infiltrating T cells. Thus results in attenuation of T cell activation and evasion of immune surveillance, which contributes to impaired antitumor immune responses. (Keir M E et al. (2008) Annu. Rev. Immunol. 26:677).

[0182] In accordance with a further aspect, the present invention covers combinations comprising one or more of the compounds of general formula (I), as described supra, or stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, particularly pharmaceutically acceptable salts thereof, or mixtures of same, and one or more immune checkpoint inhibitors.

[0183] In a further embodiment the immune checkpoint inhibitor is a aPD-1 / -L1 axis antagonist.

[0184] A further use of the compounds of the invention is the combination with chimeric antigen receptor T cells (CAR-T cells) such as Axicabtagen-Ciloleucel or Tisagenlecleucel. The activity of CAR-T cells can be suppressed by the tumor micro environment (TME), which supposedly can be overcome by MAP4K1 inhibition.

[0185] In accordance with a further aspect, the present invention covers compounds of general formula (I), as described herein, or stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, particularly pharmaceutically acceptable salts thereof, or mixtures of same, for use in the expansion of T cells including CAR-T cells, CAR-NKT cells or CAR-NK cells and tumor infiltrated lymphocytes ex-vivo.

[0186] Hence, the present invention also relates to the use of the compounds according to the invention for the expansion of T cells, including CAR-T cell, CAR-NKT cells or CAR-NK cells and tumor infiltrated lymphocytes, ex-vivo.

[0187] The present invention also comprises an ex-vivo method for the expansion of T cells, including CAR-T cells, CAR-NKT cells or CAR-NK cells and tumor infiltrated lymphocytes, contacting said T cells with compounds according to the invention.

[0188] In addition, the inventive compounds can also be used as a therapeutic in a variety of other disorders wherein MAP4K1 is involved such as, cardiovascular and lung diseases.

[0189] Accordingly, the compounds according to the invention are suitable for the treatment and / or prophylaxis in particular of cardiovascular, inflammatory and fibrotic disorders and of renal disorders, in particular of acute and chronic renal insufficiency, and also of acute and chronic renal failure.

[0190] Accordingly, the compounds according to the invention can be used in medicaments for the treatment and / or prophylaxis of cardiovascular, inflammatory and fibrotic disorders, renal disorders, in particular of acute and chronic renal insufficiency, and also of acute and chronic renal failure.

[0191] For the purpose of the present invention the term renal insufficiency comprises both acute and chronic manifestations of renal insufficiency, and also underlying or related renal disorders such as diabetic and non-diabetic nephropathies, hypertensive nephropathies, ischaemic renal disorders, renal hypoperfusion, intradialytic hypotension, obstructive uropathy, renal stenoses, glomerulopathies, glomerulonephritis (such as, for example, primary glomerulonephritides; minimal change glomerulonephritis (lipoidnephrosis); membranous glomerulonephritis; focal segmental glomerulosclerosis (FSGS); membrane-proliferative glomerulonephritis; crescentic glomerulonephritis; mesangioproliferative glomerulonephritis (IgA nephritis, Berger's disease); post-infectious glomerulonephritis; secondary glomerulonephritides: diabetes mellitus, lupus erythematosus, amyloidosis, Goodpasture syndrome, Wegener granulomatosis, Henoch-Schönlein purpura, microscopic polyangiitis, acute glomerulonephritis, pyelonephritis (for example as a result of: urolithiasis, benign prostate hyperplasia, diabetes, malformations, abuse of analgesics, Crohn's disease), glomerulosclerosis, arteriolonecrose of the kidney, tubulointerstitial diseases, nephropathic disorders such as primary and congenital or aquired renal disorder, Alport syndrome, nephritis, immunological kidney disorders such as kidney transplant rejection and immunocomplex-induced renal disorders, nephropathy induced by toxic substances, nephropathy induced by contrast agents, diabetic and non-diabetic nephropathy, renal cysts, nephrosclerosis, hypertensive nephrosclerosis and nephrotic syndrome which can be characterized diagnostically, for example by abnormally reduced creatinine and / or water excretion, abnormally elevated blood concentrations of urea, nitrogen, potassium and / or creatinine, altered activity of renal enzymes, for example glutamyl synthetase, altered urine osmolarity or urine volume, elevated microalbuminuria, macroalbuminuria, lesions on glomerulae and arterioles, tubular dilatation, hyperphosphataemia and / or the need for dialysis. The present invention also comprises the use of the compounds according to the invention for the treatment and / or prophylaxis of sequelae of renal insufficiency, for example pulmonary oedema, heart failure, uremia, anemia, electrolyte disturbances (for example hypercalemia, hyponatremia) and disturbances in bone and carbohydrate metabolism.

[0192] The present invention also comprises the use of the compounds according to the invention for the treatment and / or prevention of sequelae of renal insufficiency, for example pulmonary oedema, heart failure, uraemia, anaemia, electrolyte disturbances (for example hyperkalaemia, hyponatraemia) and disturbances in bone and carbohydrate metabolism.

[0193] The compounds according to the invention are further suitable for the treatment and / or prevention of polycystic kidney disease (PCKD) and of the syndrome of inappropriate ADH secretion (SIADH).

[0194] Furthermore, the compounds according to the invention are also suitable for the treatment and / or prophylaxis of metabolic syndrome, hypertension, resistant hypertension, acute and chronic heart failure, coronary heart disease, stable and unstable angina pectoris, peripheral and cardiac vascular disorders, arrhythmias, atrial and ventricular arrhythmias and impaired conduction, for example atrioventricular blocks degrees I-III (AB block I-III), supraventricular tachyarrhythmia, atrial fibrillation, atrial flutter, ventricular fibrillation, ventricular flutter, ventricular tachyarrhythmia, Torsade de pointes tachycardia, atrial and ventricular extrasystoles, AV-junctional extrasystoles, sick sinus syndrome, syncopes, AV-nodal re-entry tachycardia, Wolff-Parkinson-White syndrome, of acute coronary syndrome (ACS), autoimmune cardiac disorders (pericarditis, endocarditis, valvolitis, aortitis, cardiomyopathies), shock such as cardiogenic shock, septic shock and anaphylactic shock, aneurysms, boxer cardiomyopathy (premature ventricular contraction (PVC)), for treatment and / or prophylaxis of thromboembolic disorders and ischaemias such as myocardial ischaemia, myocardial infarction, stroke, cardiac hypertrophy, transient and ischaemic attacks, preeclampsia, inflammatory cardiovascular disorders, spasms of the coronary arteries and peripheral arteries, oedema formation, for example pulmonary oedema, cerebral oedema, renal oedema or oedema caused by heart failure, peripheral circulatory disturbances, reperfusion damage, arterial and venous thromboses, myocardial insufficiency, endothelial dysfunction, to prevent restenoses, for example ...

Claims

1. Compound of formula (I) wherein A is selected from a single bond, -CH2- or -O-; E is -(CH2)n- with n = 1 or 2; G is -(CH2)- and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 5 membered heterocycloalkyl; Q is selected from N or C-R2; R1 is selected from • -NO2; -CN; • C1-4-alkyl optionally substituted by -OH or 1 to 3 -F; • cyclopropyl; • 4 to 6 membered heterocycloalkyl or heterocycloalkenyl, both with 1- 2 nitrogen atoms, but always linked via a carbon atom to the phenyl group of compounds of formula (I) and both optionally substituted by C1-4-alkyl; • phenyl optionally substituted by halogen, -CN, C1-4-alkyl, C1-4-haloalkyl, C3-6-cycloalkyl, O-C1-4-alkyl, O-C3-6-cycloalky, C1-3-alkinyl, -C(O)-Rd, SRd, SORd, SO2Rd, SONRd, SON(H)Rd, -SO2-NH2, -SO2-N(H)-Rd or -SO2-N(R4)2, wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • 5 to 6 membered heteroaryl with 1, 2 or 3 heteroatoms selected from N, O or S and optionally substituted by 1 or 2 of the following substituents: halogen, -CN, C1-4-alkyl, C1-4-haloalkyl, C3-6-cycloalkyl, O-C1-4-alkyl, O-C3-6-cycloalkyl, C1-3-alkinyl, SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • -O-CH3; -O-CH(CH3)2; -O-CHF2; -O-CF3; • -O-CHRa-phenyl optionally substituted by one, two or three of the following substituents: halogen, -CN, C1-4-alkyl optionally substituted by one or more -F, O-C1-4-alkyl, C1-6-alkinyl-OH or -SO2-CH3 and with Ra selected from -H, -F or -CH3, -CF3, -CH2-CH3, -CH(CH3)2 or -cyclopropyl; • -O-CHRa-6 membered heteroaryl optionally substituted one, two or three of the following substituents: halogen, -CN, C1-4-alkyl optionally substituted by one or more -F or -SO2-CH3 and with Ra selected from -H, -F or -CH3, -CF3, -CH2-CH3, -CH(CH3)2 or -cyclopropyl; • -COORa with Ra selected from -H or -CH3; • C(=O)-methyl, optionally substituted by 1 to 3 -F; • -C(=O)-NRbRc wherein Rb is selected from -H, -CH3 or -CH2-CH3 and wherein Rc is selected from - H, -CH3, -CH2-CH3, cyclohexyl, phenyl or 5 to 6 membered heteroaryl, all optionally substituted by one or two halogen, -CN, -SO2-CH3 or C1-4-alkyl, optionally substituted one or more times with halogen; • -S-CRfRgRh, wherein Rf is selected from -H or -F, wherein Rg is selected from -H, -F or -CH3 and wherein Rh is selected from H, F, -CH3 or C5-6-cycloalkyl or phenyl; • R2 is selected from -H; R4 is selected from • C1-6-alkyl, C3-6-cycloalkyl or C1-3alkyl-C3-6-cycloalkyl, all optionally substituted one or independently more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -ORi wherein Ri is selected from C1-4-alkyl or C3-6-Cycloalkyl, both optionally substituted one or more times by halogen, ∘ -CF3, -CHF2, -CH2F, or -CH2-CF3; ∘ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl, ∘ -CH2-O-CH3 or ∘ C3-4 cycloalkyl or 4-6 membered heterocycloalkyl, both optionally substituted by (=O), or optionally substituted one or more times by F or CH3; ∘ C6-8-spiro-alkyl and C5-7-bicyclo-alkyl ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; or ∘ phenyl is optionally substituted one or more times by -C(O)NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl or ∘ 5 to 6 membered heteroaryl is optionally substituted one or more times by -OH; • C(=O)-RI in which RI is selected from ∘ C1-4-alkyl, C3-6-cycloalkyl or C3-6-heterocycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -ORi with Ri selected from C1-4-alkyl or C3-6Cycloalkyl), -CF3, -CHF2, -CH2F; ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by • halogen, -CN, • -CF3, -CHF2, -CH2F, • C1-4-alkyl optionally substituted with one or more halogen; • C3-6-cycloalkyl; • O-C1-4-alkyl, • O-C3-6-cycloalky, • C1-3-alkinyl, • -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl • SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • C(=O)-NRoRp wherein Ro and Rp are independently selected from ∘ H ∘ C1-4-alkyl, C3-6-cycloalkyl or C1-3alkyl-C3-6-cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -ORi with Ri selected from C1-4-alkyl or C3-6-cycloalkyl, -CF3, -CHF2, -CH2F; ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by • halogen, -CN, • -CF3, -CHF2, -CH2F, • C1-4-alkyl optionally substituted with one or more halogen; • C3-6-cycloalkyl; • O-C1-4-alkyl, • O-C3-6-cycloalky, • C1-3-alkinyl, • -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl • SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

2. Compound of formula (la) according to claim 1 wherein A is selected from a single bond, -CH2- or -O-; E is -(CH2)n- with n = 1 or 2; G is -(CH2)- and with the condition, that the cyclic substructure comprising E-N-G is a 4 to 5 membered heterocycloalkyl; R1 is selected from • -NO2; -CN; • C1-4-alkyl optionally substituted by -OH or 1 to 3 -F; • cyclopropyl; • 4 to 6 membered heterocycloalkyl or heterocycloalkenyl, both with 1- 2 nitrogen atoms, but always linked via a carbon atom to the phenyl group of compounds of formula (I) and both optionally substituted by C1-4-alkyl; • phenyl optionally substituted by halogen, -CN, C1-4-alkyl, C1-4-haloalkyl, C3-6-cycloalkyl, O-C1-4-alkyl, O-C3-6-cycloalky, C1-3-alkinyl, -C(O)-Rd, SRd, SORd, SO2Rd, SONRd, SON(H)Rd, -SO2-NH2, -SO2-N(H)-Rd or -SO2-N(R4)2, wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • 5 to 6 membered heteroaryl with 1 or 2 heteroatoms selected from N or S and optionally substituted by halogen, -CN, C1-4-alkyl, C1-4-haloalkyl, C3-6-cycloalkyl, O-C1-4-alkyl, O-C3-6-cycloalkyl, C1-3-alkinyl, SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • -O-CH3; -O-CH(CH3)2; -O-CHF2; -O-CF3; • -O-CHRa-phenyl optionally substituted by one or two of the following substituents: halogen, - CN, C1-4-alkyl optionally substituted by one or more -F or -SO2-CH3 and with Ra selected from - H, -F or -CH3, -CF3, -CH2-CH3, -CH(CH3)2 or -cyclopropyl; • -O-CHRa-6 membered heteroaryl optionally substituted one or two of the following substituents: halogen, -CN, C1-4-alkyl optionally substituted by one or more -F or -SO2-CH3 and with Ra selected from -H, -F or -CH3, -CF3, -CH2-CH3, -CH(CH3)2 or -cyclopropyl; • -COORa with Ra selected from -H or -CH3; • C(=O)-methyl, optionally substituted by 1 to 3 -F; • -C(=O)-NRbRc wherein Rb is selected from -H, -CH3 or -CH2-CH3 and wherein Rc is selected from - H, -CH3, -CH2-CH3, cyclohexyl, phenyl or 5 to 6 membered heteroaryl, all optionally substituted by one or two halogen, -CN, -SO2-CH3 or C1-4-alkyl, optionally substituted one or more times with halogen; • -S-CRfRgRh, wherein Rf is selected from -H or -F, wherein Rg is selected from -H, -F or -CH3 and wherein Rh is selected from H, F, -CH3 or C5-6-cycloalkyl or phenyl; • R2 is selected from -H,; or R4 is selected from • C1-5-alkyl or C3-6-cycloalkyl, both optionally substituted one or independently more times by ∘ -F, -Cl, -Br, -CN; ∘ -OH, -ORi wherein Ri is selected from C1-4-alkyl or C3-6Cycloalkyl), ∘ -CF3, -CHF2, -CH2F, or -CH2-CF3; ∘ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl, ∘ -CH2-O-CH3 or ∘ C3-4 cycloalkyl or 4 membered heterocycloalkyl, both optionally substituted by -F or - CH3; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • C(=O)-RI in which RI is selected from ∘ C1-4-alkyl, C3-6-cycloalkyl or C3-6-heterocycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -ORi with Ri selected from C1-4-alkyl or C3-6Cycloalkyl), -CF3, -CHF2, -CH2F; ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by • halogen, -CN, • -CF3, -CHF2, -CH2F, • C1-4-alkyl optionally substituted with one or more halogen; • C3-6-cycloalkyl; • O-C1-4-alkyl, • O-C3-6-cycloalky, • C1-3-alkinyl, • -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl • SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; ∘ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; • C(=O)-NRoRp wherein Ro and Rp are independently selected from ∘ H ∘ C1-4-alkyl or C3-6-cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -ORi with Ri selected from C1-4-alkyl or C3-6-cycloalkyl, -CF3, -CHF2, -CH2F; ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by • halogen, -CN, • -CF3, -CHF2, -CH2F, • C1-4-alkyl optionally substituted with one or more halogen; • C3-6-cycloalkyl; • O-C1-4-alkyl, • O-C3-6-cycloalky, • C1-3-alkinyl, • -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl • SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; o phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by ▪ halogen, -CN, ▪ -CF3, -CHF2, -CH2F, ▪ C1-4-alkyl optionally substituted with one or more halogen; ▪ C3-6-cycloalkyl; ▪ O-C1-4-alkyl, ▪ O-C3-6-cycloalky, ▪ C1-3-alkinyl, ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

3. Compounds of formula (I) according to claim 1, wherein A is selected from a single bond or -O-or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

4. Compounds of formula (I) according to claim 1, wherein E is -CH2-CH2- or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

5. Compounds of formula (I) according to claim 1, wherein Q is C-R2 or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

6. Compounds of formula (I) according to claim 1, wherein Q is N or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

7. Compounds of formula (I) according to claim 1, wherein R4 is and Rq is selected from H, -CH3,-CH2-CH3, -CH(CH3)2, -CH2-O-CH3, -CF3, -CHF2, -CH2F, -CH2-CF3, cyclopropyl or cyclobutyl or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

8. Compounds of formula (I) according to claim 1, wherein R4 is selected from C(=O)-NRoRp wherein Ro and Rp are independently selected from ∘ H ∘ C1-4-alkyl or C3-6-cycloalkyl, both optionally substituted one or more times by ▪ -F, -Cl, -Br, -CN; ▪ -OH, -ORi with Ri selected from C1-4-alkyl or C3-6-cycloalkyl, -CF3, -CHF2, -CH2F; ▪ -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl ▪ phenyl or 5 to 6 membered heteroaryl, both optionally substituted one or more times by • halogen, -CN, • -CF3, -CHF2, -CH2F, • C1-4-alkyl optionally substituted with one or more halogen; • C3-6-cycloalkyl; • O-C1-4-alkyl, • O-C3-6-cycloalky, • C1-3-alkinyl, • -NRjRk wherein Rj and Rk are independently selected from -H and C1-C4-alkyl • SRd, SORd, SO2Rd, SONRd or SON(H)Rd wherein Rd is selected from methyl, ethyl, cyclopropyl, isopropyl and tert-butyl; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

9. Compound according to claim 1, which is selected from: (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1R)-1-[3-(trifluoromethyl)phenyl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1S)-1-[3-(trifluoromethyl)phenyl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)phenyl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-phenyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereometric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{(1S)-1-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]ethyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1,2-oxazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(oxan-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(15)-1-(1-ethyl-5-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-methyl-1H-benzimidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(4-fluorophenyl)-2-methoxyethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-ethyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(1-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrazin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2-methoxy-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridazin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methylpiperidin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[3-(methylsulfamoyl)pyridin-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxopiperidin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(2-cyclopropylpropan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-methyl-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[-2-methyl-1-phenylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2,2,2-trifluoro-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyrazin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of isomers) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridazin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-cyanophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(15)-2,3-dihydro-1H-inden-1-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'RS)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{1-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]ethyl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-5-methyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(6-cyanopyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(2-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(4-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]methyl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrimidin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluoropyridin-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyrimidin-5-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-chloropyridin-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorophenyl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(pyridin-3-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-5-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'RS)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(bicyclo[1.1.1]pentan-1-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(1,2-oxazol-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorobicyclo[1.1.1]pentan-1-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(bicyclo[1.1.1]pentan-1-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-fluorobicyclo[1.1.1]pentan-1-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 2) 2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (enantiomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(3S)-2,3-dihydro-1-benzofuran-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(2-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(4-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(pyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (mixture of stereoisomer) 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-benzyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-cyanopyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-cyanopyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide acetate (1:1) (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylpropyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1S)-1-(pyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(propan-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(bicyclo[2.2.1]heptan-1-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-benzylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(4-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-methylcyclobutyl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[(1R)-2,3-dihydro-1H-inden-1-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1S)-2-methoxy-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-(5-fluoropyridin-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(trifluoromethyl)sulfanyl]pyridin-3-yl}-N-[(1R)-1-(3-fluorophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3R)-2,3-dihydro-1-benzofuran-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-imidazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(1-methyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(pyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-cyanophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide [2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl](1H-imidazol-1-yl)methanone (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-methylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(3-methyloxetan-3-yl})-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-(6-amino-5-cyanopyridin-3-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(pyridin-4-yl)ethyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chlorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-fluorophenyl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(4-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(2-chlorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (mixture of stereoisomer) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(2-chloro-4-cyanophenyl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluorophenyl)cyclobutyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3,5-difluorophenyl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(5-fluoropyridin-2-yl)-2-methylpropan-1-one (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(1-phenylcyclohexyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(5-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-2,2,2-trifluoro-1-methoxy-1-phenylethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyrimidin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyrimidin-5-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(3-phenyloxetan-3-yl)methanone (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(3,5-difluorophenyl)-2-methylpropan-1-one (rac)-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-methyl-2-(6-methylpyridin-3-yl)propan-1-one (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(3-phenyloxetan-3-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chlorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-fluorophenyl)methoxy]pyridin-3-yl}-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-fluorophenyl)methoxy]pyridin-3-yl}-N-benzyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-2-yl)methoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chloro-5-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(2-chloro-5-fluorophenyl)methoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-[6-amino-5-(benzyloxy)pyridin-3-yl]-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(pyridazin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) 2'-{6-amino-5-[(pyridazin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) (3S)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) (3S)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) (rac)-2'-(2-amino-1'-methyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-(6-amino-5-cyanopyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(difluoromethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(trifluoroacetyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-phenylethyl]sulfanyl}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2'-{6-amino-5-[(cyclohexylmethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(benzylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-cyclohexylethyl]sulfanyl}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(cyclopentylmethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-nitropyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(benzyloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-methylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-(6-amino-5-nitropyridin-3-yl)-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide methyl 2-amino-5-[(rac)-1-(ethylcarbamoyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridine-3-carboxylate (rac)-2'-(6-amino-5-phenylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(methylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(4-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-methylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-methoxypyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-fluorophenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(2-amino[3,3'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(2-fluorophenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) (rac)-2-[6-amino-5-(2-fluorophenyl)pyridin-3-yl]-N-ethyl-6,7-dihydro-5H-spiro[pyrazolo[1,5-a]pyridine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(2-methoxyphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(2-amino[3,4'-bipyridin]-5-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[3-(methanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(phenylsulfanyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[5-(4-acetylphenyl)-6-aminopyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methanesulfinyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(3-methoxyphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(cyclopropanesulfonyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(4-sulfamoylphenyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(methylsulfamoyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[4-(dimethylsulfamoyl)phenyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(cyclohexylmethoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(pyridin-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(4-fluorophenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-{[1-phenylethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomeric mixture) 2-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(propan-2-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(6-amino-5-cyclopropylpyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(methylcarbamoyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(dimethylcarbamoyl)pyridin-3-yl]-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1,2-thiazol-5-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(trifluoromethyl)sulfanyl]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-[1-methyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-[1-methyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) ((3R)-2'-{6-amino-5-[1-(pyrimidin-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) (rac)-2'-[6-amino-5-(difluoromethyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1S)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(2-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(3-methylphenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1-methyl-1H-pyrazol-5-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1-methyl-1H-pyrazol-4-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(1,5-dimethyl-1H-pyrazol-3-yl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(4-methylphenyl)methoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-{6-amino-5-[(1R)-1-(3-methylphenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-{6-amino-5-[(propan-2-yl)oxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1-methyl-1H-pyrazol-3-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{[1-(3,5-difluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 1) (3R)-2'-(6-amino-5-{[1-(3,5-difluoropyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (stereoisomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1S)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-(1-phenylcyclobutyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethoxy)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3R)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-(6-amino-5-cyanopyridin-3-yl)-N-[2-(pyridin-2-yl)propan-2-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (rac)-2'-[6-amino-5-(phenylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(cyclohexylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-[6-amino-5-(diethylcarbamoyl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (rac)-2'-(5-acetyl-6-aminopyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{1-[1-(1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1-methyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(4-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(3-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(4-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-[(3S)-1-(pyridin-3-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-3-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-[(3S)-1-(1H-imidazol-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(1H-imidazol-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(4-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-pyrazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1H-imidazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-imidazol-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(4-chloro-1H-pyrazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 3-[(2-fluorophenyl)methoxy]-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 3-[(3-fluorophenyl)methoxy]-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1'-[(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-5-{1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridine-3-carbonitrile 5-{(rac)-1-[(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(1-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-5-{(rac)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridine-3-carbonitrile 5-{1-[(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(5-methyl-1H-pyrazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(rac)-1-[(2,4-dimethyl-1H-imidazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) 5-{(3R)-1-[(1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (stereoisomer 2) 5-{(3R)-1-[1-(1-methyl-1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 3-(trifluoromethyl)-5-[(3R)-1-{[4-(trifluoromethyl)-1H-imidazol-2-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridin-2-amine 2-amino-5-[(rac)-1-(ethylcarbamoyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]pyridine-3-carboxylic acid 5-[(3S)-1-(pyridin-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-2-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3S)-1-(pyridin-4-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-[(3R)-1-(pyridin-4-ylmethyl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl]-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[3-(dimethylamino)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[2-(dimethylamino)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (stereoisomer 2) 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (stereoisomer 1) 2-amino-1-{2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethan-1-one (stereoisomer 2) 2-amino-1-{2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethan-1-one (stereoisomer 1) 2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}ethan-1-one (2S)-2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propan-1-one (2R)-2-amino-1-{2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propan-1-one (rac)-2'-[6-amino-5-(1-methylpiperidin-4-yl)pyridin-3-yl]-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(rac)-1-[(5-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 1) 2'-{6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (isomer 2) 5-{(3'R)-1'-[(1S)-1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(1R)-1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3'R)-1'-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine 5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine 5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine 3-(difluoromethoxy)-5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 3-(difluoromethoxy)-5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 2-amino-5-{(3R)-1-[(R)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(S)-cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(1R)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile 2-amino-5-{(3R)-1-[(1S)-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (3R)-2'-(6-amino-5-{[1-(6-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(6-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(5-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(5-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(4-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(3-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(3-methylpyridin-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-(6-amino-5-{[-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(1,4-dimethyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1S)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(2-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-1H-pyrazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(1-phenylpropoxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1S)-1-(3-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1S)-1-(4-cyanophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1S)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,4-trimethyl-1H-pyrazol-5-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-4-yl)ethyl]-6,7-dihydro-1'H-spiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine]-1'-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3,5-difluoropyridin-4-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(1-methyl-1H-pyrazol-5-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1 and enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1 and enantiomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{methyl[(1R)-1-phenylethyl]amino}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-fluoropyridin-2-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl)(cyclopropyl)methanone 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) 2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (35)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3S)-2'-[6-am ino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-1,2,4-triazol-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-1,2,4-triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-1,2,4-triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-1,2,4-Triazol-5-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethyl)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}nicotinonitrile (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 2) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1 and enantiomer 2) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1) 5-{1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 2) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclobutyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)-2-methylpropyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclobutyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2,2-dimethylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1 and enantiomer 2) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 1) 5-{1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (enantiomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3S)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3S)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3S)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(difluoromethoxy)pyridin-2-amine (diastereomer 2) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 1) 2-amino-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}nicotinonitrile (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethoxy)-5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)-2-methylpropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3S)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3S)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3S)-1-[1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer2) {(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(1H-imidazol-2-yl)methanone {(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(1-methyl-1H-imidazol-2-yl)methanone 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-{(3R)-1-[(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}pyridin-2-amine 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-chloropyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-3-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1S)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-(6-amino-5-cyanopyridin-3-yl)-N-[1-(pyridin-4-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-methylpyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclobutyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[2-methyl-1-(pyridin-4-yl)propyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(1R)-1-(3-chloropyridin-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-methylpyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(3-methoxypyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-4-yl)cyclopropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(2-methoxyphenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 1 and diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 1) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzonitrile (diastereomer 2) (3S)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 1) (3R)-2'-(6-amino-5-cyanopyridin-3-yl)-N-[2-(3-chloropyridin-4-yl)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (enantiomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-chlorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-{6-amino-5-[1-(2,6-dichlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3R)-1-[1-(1H-pyrrol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-methoxypyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1-methyl-1H-pyrazol-5-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 1 and diastereomer 2) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 1) 3-(1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}propyl)benzamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(3-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(2-chloro-3-fluoropyridin-4-yl)ethyl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-{[3-(methylsulfanyl)pyridin-4-yl]methyl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(1,3-dimethyl-1H-pyrazol-4-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[1-(pyridin-2-yl)cyclopropyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(pyrimidin-5-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,3-thiazol-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[(3-methylpyridin-4-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(6-methoxypyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(6-methoxypyridin-2-yl)ethyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-(6-amino-5-{1-[3-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl]ethoxy}pyridin-3-yl)-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[1-(1,3-oxazol-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(3-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) 5-{(3R)-1-[cyclopropyl(5-fluoropyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyrimidin-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-fluorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(4-fluorophenyl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1,3-thiazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(4-chlorophenyl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[1-(dimethylamino)propan-2-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(1,2-thiazol-5-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 6-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyridin-2(1H)-one (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-3-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (4 isomers) (3R)-2'-{6-amino-5-[1-(1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1,3-thiazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine 6-({(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}methyl)pyridin-2(1H)-one (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3S)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-N-[cyclopropyl(phenyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-[6-amino-5-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yloxy)pyridin-3-yl]-N-ethyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) 2'-{6-amino-5-[(1R)-1-(pyridin-2-yl)ethoxy]pyridin-3-yl}-N-ethyl-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(methylamino)ethan-1-one (2R)-1-{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}-2-(methylamino)propan-1-one (5R)-5-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyrrolidin-2-one 5-{(3R)-1-[(1,3,4-thiadiazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (5S)-5-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}methyl)pyrrolidin-2-one 5-{(3'R)-1'-[1-(6-methoxypyridin-2-yl)ethyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(6-methoxypyridin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(6-methoxypyridin-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(3-fluoropyridin-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethoxy)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 2) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 1 and diastereomer 2) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 1) 2-amino-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridine-3-carbonitrile (diastereomer 2) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 1) 3-(difluoromethyl)-5-{(3'R)-1'-[1-(1H-imidazol-2-yl)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}pyridin-2-amine (diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1-propyl-1H-pyrazol-5-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(1,3-thiazol-4-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(pyrimidin-4-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(2,4-dimethylpyrimidin-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1) (3R)-2'-(6-amino-5-{[1-(2,4-dimethylpyrimidin-5-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(1-methyl-1H-1,2,3-triazol-5-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-(6-amino-5-{[1-(1-methyl-1H-1,2,3-triazol-4-yl)ethyl]oxy}pyridin-3-yl)-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (5S)-5-{[(3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl]methyl}pyrrolidin-2-one (5R)-5-{[(3R)-2'-{6-amino-5-[(1R)-1-phenylethoxy]pyridin-3-yl}-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl]methyl}pyrrolidin-2-one (3R)-2'-(6-amino-5-{1-[4-(methylsulfonyl)phenyl]ethoxy}pyridin-3-yl)-N-isopropyl-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(2-methyl-1,3-thiazol-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-[6-amino-5-({1-[3-(methanesulfonyl)phenyl]ethyl}oxy)pyridin-3-yl]-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4-methyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(4,5-dimethyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-(6-amino-5-{[1-(5-methyl-1,3-thiazol-2-yl)ethyl]oxy}pyridin-3-yl)-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (diastereomer 1 and diastereomer 2) (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-(propan-2-yl)-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide (3R)-2'-{6-amino-5-[(1R)-1-(pyridin-4-yl)ethoxy]pyridin-3-yl}-N-cyclobutyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 1) 6-(1-{(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}ethyl)pyridin-2-ol (diastereomer 2) 6-({(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(cyclopropyl)methyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 6-({(3'R)-2-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-1'-yl}(cyclopropyl)methyl)pyridin-2-ol (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 1) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 2) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 3) 5-{1'-[(3,3-difluorocyclobutyl)(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (isomer 4) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclopropyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclohexyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclohexyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1H-imidazol-2-yl)(1-methylcyclobutyl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-pyrazol-3-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-methylcyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diasteroemr 1 and diastereomer 2) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(4-chloro-1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(3,3-difluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1-methyl-1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(4H-1,2,4-triazol-3-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(4H-1,2,4-triazol-3-yl)(1-2H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diatereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1-2H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1-2H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[1-(1H-imidazol-2-yl)(1-2H)propyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[1-(1H-imidazol-2-yl)(1-2H)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)(2H)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(2-methoxypyridin-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 3-[{(3R)-2'-[6-amino-5-(trifluoromethyl)pyridin-3-yl]-5',6'-dihydro-1H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-1-yl}(cyclopropyl)methyl]pyridin-2(1H)-one (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(1-fluorocyclopropyl)(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(4-methoxypyrimidin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclobutyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3'R)-1'-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(1-fluorocyclobutyl)(4H-1,2,4-triazol-3-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(pyrimidin-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(2,6-difluorophenyl)ethoxy]pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-[(1R)-1-(3-fluoropyridin-2-yl)ethoxy]pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopentyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[(4,4-difluorocyclohexyl)(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3R)-1-[2,2-difluoro-1-(1H-imidazol-2-yl)propyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,3-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 2) 5-{(3'R)-1'-[cyclobutyl(4H-1,2,4-triazol-3-yl)methyl]-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidin]-2-yl}-3-(trifluoromethyl)pyridin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-1,2,4-triazol-5-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethoxy)pyridin-2-amine (diastereomer 2) (3R)-2'-{5-amino-6-[(1R)-1-phenylethoxy]pyrazin-2-yl}-N-ethyl-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxamide 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1 and diastereomer 2) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 1) 5-{(3R)-1-[cyclopropyl(1H-imidazol-2-yl)methyl]-5',6'-dihydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-b]pyrazol]-2'-yl}-3-(trifluoromethyl)pyrazin-2-amine (diastereomer 2) or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

10. A compound of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 for the use as a medicament.

11. A compound of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 for use in the treatment or prophylaxis of a disease.

12. A pharmaceutical composition comprising a compound of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 and one or more pharmaceutically acceptable excipients.

13. A pharmaceutical combination comprising: one or more first active ingredients being compounds of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 and one or more pharmaceutical active anti cancer compounds or one or more pharmaceutical active immune checkpoint inhibitors.

14. A pharmaceutical combination according to claim 13, characterized in that the pharmaceutical active immune checkpoint inhibitor is an antibody.

15. A compound of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 for use in the treatment or prophylaxis of cancer, a benign hyperplasia, an atherosclerotic disorder, sepsis, an autoimmune disorder, a vascular disorder, a viral infection, a neurodegenerative disorder, or an inflammatory disorder.

16. Use of a compound of general formula (I) according to any one of claims 1, 2, 3, 4, 5, 6, 7, 8 or 9 for male fertility control.

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