System for processing pharmaceutical packaging means, method for operating such a system, and monitoring device

Abstract

The invention relates to a system (100) for processing pharmaceutical packaging means (102), comprising: a system (106) for processing the packaging means (102), said system comprising a processing chamber (126) and at least one processing station (136, 146), which is arranged in the processing chamber (126), for the packaging means (102), an insertion opening (128) which can be opened and closed via a closing element (130) being formed in a wall (124, 178) of the system (106); a portable container (110) which comprises an interior (198) for receiving at least one pharmaceutical production element (154) and a container opening (196) that can be opened and closed via a closing element (194), wherein the container (110) can be docked onto the system (106), and the at least one production element (154) comprises a production element (154) which can be transferred from the interior (198) into the processing chamber (126) when the closing element (130, 194) is opened; and a monitoring device (164) which comprises at least one reading unit (166, 190, 206, 208) and at least one identification element (168) that is arranged on the at least one production element (154) or is enclosed by same. State information relating to the production element (154) is stored on or in the at least one identification element (168), in particular in a storage element (170) of the identification element (168), and the state information can be read contactlessly by means of the at least one reading unit (166, 190, 206, 208). The invention additionally relates to a monitoring device (164) and to a method.

Description

[0001] System for processing pharmaceutical packaging, method for operating such a system and monitoring device

[0002] The present invention relates to a system for processing pharmaceutical packaging materials, which comprises a plant for processing the packaging materials, wherein the plant comprises a processing space and at least one processing station for the packaging materials arranged in the processing space, and wherein an insertion opening which can be closed and opened via a closing element is formed in a wall of the plant.

[0003] Furthermore, the present invention relates to a monitoring device for such a system and a method for operating a system for processing pharmaceutical packaging materials.

[0004] When installing the system of the type mentioned above, pharmaceutical packaging can be processed at the at least one processing station. The packaging can be primary packaging, such as containers that can be filled with a pharmaceutical product. The containers can be, for example, vials, syringes, cartridges, or ampoules. The containers can be stable or non-stable. Alternatively or additionally, the packaging can be, for example, secondary packaging, which in turn accommodates primary packaging, for example, tubs, trays, or nests. The at least one processing station can be, for example, an unpacking station for the secondary packaging, a weighing station, a filling station for filling the primary packaging, or a closing station for sealing it. Other types of processing stations are conceivable.

[0005] It is known that packaging materials and pharmaceutical production elements can be fed through the feed opening. For this purpose, there are portable containers that can be docked onto the system. With the container and feed opening open, the packaging materials and production elements are removed from the container and transferred to the processing room for processing.

[0006] In this example, the packaging materials can be considered pharmaceutical production elements, which can also be referred to as pharmaceutical production materials. Other types of production elements include, for example, machine parts, in particular those of at least one processing station, or format parts that are adapted, for example, to the packaging materials to be processed.

[0007] It is desirable to be able to ensure the highest possible process reliability during plant operation, preferably with the production cycle being as comprehensively reproducible as possible. For process reliability, it can be advantageous to instruct a user and prevent any incorrect operation of the plant or system.

[0008] The object of the present invention is to provide a system for processing pharmaceutical packaging materials with a plant for processing the packaging materials, in which increased process reliability can be guaranteed.

[0009] This object is achieved by a system according to the invention for processing pharmaceutical packaging materials, comprising: a system for processing the packaging materials, which comprises a processing space and at least one processing station for the packaging materials arranged in the processing space, wherein an insertion opening which can be closed and opened via a closing element is formed in a wall of the system, a transportable container which comprises an interior space for receiving at least one pharmaceutical production element and a container opening which can be closed and opened via a closing element, wherein the container can be docked to the system, wherein the at least one production element comprises a production element which can be transferred from the interior space into the processing space when the closing elements are open, and a monitoring device which comprises at least one reading unit and at least one identification element,which is arranged on the at least one production element or encompassed by it, wherein status information about the production element is stored on or in the at least one identification element, in particular stored in a memory element of the identification element, wherein the status information can be read out contactlessly by means of the at least one reading unit. In the system according to the invention, production elements are provided which are used in the processing of the pharmaceutical packaging. At least some of the production elements can be accommodated in the transportable container. The container can be docked to the system and, in particular, detachably connected to the system. The container is docked to the system, in particular on the outside, for example, to a wall of the system. If the container is docked to the system and the respective closing element is open,A production element held in the container can be transferred into the processing space and used therein. According to the present invention, the system comprises a monitoring device, wherein an identification element is arranged on or encompassed by at least one production element. Status information can be read out contactlessly via at least one reading unit. Based on the status information, it is advantageously possible to check and / or track the use of production elements. It is preferably possible to monitor and / or track production elements over time during the production cycle. For this purpose, the status information includes, for example, identification numbers of the production elements and preferably further information,which characterize their properties in more detail. This will be discussed further below. Read status information can be processed by the system and preferably checked for compliance with an optional production plan. The production plan can, for example, store which production elements are required for a planned production of containers, and optionally, which state the production elements must assume or have. This information can be time-dependent. Reviewing the status information preferably makes it possible to monitor compliance with the production plan, intercept or preferably avoid any disruptions during processing, and / or prepare production elements for production, thereby ensuring greater process reliability.

[0010] In this case, “contactless” does not exclude the possibility that at least one reading unit is in physical contact with the production element when reading the status information.

[0011] It is understood that the system may comprise more than one system. The systems may be identical or different in design. Similarly, it may comprise more than one container. The containers may be identical or different in design.

[0012] Advantageously, the system comprises at least one data processing device with a storage unit in which status information of the at least one production element is stored. The status information can be managed and / or modified, and preferably processed, via the data processing device. The data processing device preferably enables the creation and / or modification of status information, which can be written into the memory element of the identification element via the at least one reading unit. This will be discussed further below.

[0013] The at least one data processing device can be part of a production system (MES, Manufacturing Execution System).

[0014] Redundant storage of status data in the identification elements and in at least one data processing direction can be provided.

[0015] The status information is preferably linked to a production plan relating to the processing of the packaging materials and / or the planned use of at least one production element stored in the system. The system preferably provides the option of creating a production plan that specifies which production elements are used in which way and / or which packaging materials are processed in which way. By linking the production plan with the status information, correct processing can preferably be prepared, monitored, and / or ensured. In particular, it is provided that a respective production element is used according to the production plan and, if necessary, also assumes a correct condition (e.g., by checking that the production element has been cleaned or autoclaved, by checking whether it has already been used or not, etc.).

[0016] The production plan preferably also provides the option of planning and / or monitoring partial or complete autonomous operation of the system by storing information about the production elements to be used in the production plan. Control of the system, and in particular the plant, is possible based on the status information. The at least one data processing device can be located locally on the system and, for example, on the plant. It is also conceivable for the at least one data processing device to be located spatially separate from the plant and to be implemented via one or more servers, for example, in a cloud.

[0017] Changes to the status information of at least one production element can preferably be stored in the storage unit. This allows the respective status information to be updated and, for example, a log of the production element's use to be created. Preferably, the possibility of seamless tracking of the production element is offered, for example, throughout its entire production cycle or even its life cycle. This can extend, for example, from the supplier through internal logistics and production to delivery and disposal of the production element.

[0018] The at least one data processing device can preferably create a report on the use of the at least one production element on the basis of the status information.

[0019] It is advantageous if at least one data processing device can produce a report on the processing of the production plan, which allows production processes to be monitored.

[0020] For example, depending on the use and / or consumption of the at least one production element, procurement information for procuring additional production elements can be transmitted from the at least one data processing device to a remotely located delivery facility. For example, changes in the inventory of the production element are registered and a preferably automatic ordering process is triggered, enabling efficient production planning and warehouse management.

[0021] It may also be advantageous if, through the processing of the status information by the at least one data processing device, warehouse management becomes transparent and, preferably, seamlessly traceable with regard to storage locations of production elements, storage costs, routes, and / or positions of production elements. Automatic picking of production elements based on the evaluated status information is conceivable.

[0022] It can be provided that the at least one reading unit forms the at least one data processing device or vice versa.

[0023] Alternatively, the at least one data processing device is formed separately from the at least one reading unit and coupled thereto.

[0024] Information between the at least one data processing device and the at least one reading unit can preferably be transmitted wirelessly.

[0025] It is advantageous if the status information of the at least one identification element can be changed, in particular by means of at least one reading unit, for example, with a respective reading unit. This allows the respective status of the identification element to be adapted when the status of the production element changes. For example, it is conceivable to mark the production element as cleaned, used, or similar. The reading unit(s) can form a writing device or devices, according to the above.

[0026] Furthermore, it is preferably possible to create the status information in the identification element, for example, by writing status information to the memory element for the first time. This can be done, for example, during manufacture and / or before the planned use of the production element.

[0027] The memory element of the at least one identification element can comprise two or more memory sections that differ from one another in terms of their nature. In particular, a memory section is provided whose content can only be read out, and / or a memory section whose content can be read out and changed, or which can be written to. In practice, it can be advantageous if some of the status information is static and cannot be changed. For example, information that cannot or should not change during the life cycle of the production element is stored in this memory section. On the other hand, a memory section can be provided in which information that can change is stored, thus providing the possibility of updating the status information.It may be provided that there is a memory section that can only be read using a specific reading unit.

[0028] Alternatively or additionally, a memory section can be provided which can be read out with each of the reading units.

[0029] It can be provided that a memory section is present into which status information can be written with only one specific reading unit or in which status information can be changed with the specific reading unit.

[0030] Furthermore, it can be provided that a memory section is present in which status information can be changed with each reading unit or in which status information can be written with each reading unit.

[0031] The above configuration allows, for example, different types of status information to be stored in the memory element, both from the manufacturer and from the user or customer. For example, manufacturer-side status information is used to control the system, while customer-side status information can relate to the production cycle, for example.

[0032] The at least one production element can, for example, be a format part of the system, whereby different format parts differ from one another by at least one packaging-specific property.

[0033] The at least one production element can be, for example, a machine part, for example the at least one processing station.

[0034] The at least one production element can, for example, be a pharmaceutical packaging material.

[0035] The at least one production element can, for example, be a filling element used when filling the packaging with a product. Possible filling elements include, for example, a product container for the product, a fluid line through which the product is conveyed, or a filling needle. It has already been mentioned that production elements can be provided that are introduced into the processing space. It is conceivable that production elements are provided that remain outside the processing space. Such production elements can advantageously also have an identification element.

[0036] The at least one production element is, for example, a receiving body for temporarily receiving a different type of production element, in particular in the interior of the container. The receiving body is arranged, for example, in the container and serves to temporarily receive a production element to be introduced into the processing space. The receiving body can, for example, be a magazine plate for production elements arranged in the container.

[0037] The receiving body can be arranged in an extendable manner in the container to make it easier to load it or to remove production elements.

[0038] The receiving body can, for example, be removed or pulled out of the container manually and / or using the handling device, in particular a robotic one.

[0039] As mentioned above, at least one pharmaceutical production element can be accommodated in the interior. For example, the system can include production elements used during production that are located or remain outside the facility and therefore are not or need not be located in the interior of the container.

[0040] In particular, it can be provided that the container itself is a pharmaceutical production element and comprises an identification element that can be read by the at least one reading unit. The container is also preferably monitored.

[0041] In addition to an identification number, status information relating to the container can include information related to the current contents of the container. For example, it can contain information about which production elements are stored in the container and their respective positions.

[0042] In a preferred embodiment of the invention, the monitoring device is radio-based and designed to read the at least one identification element using electromagnetic radiation, in particular using RFID. The at least one reading unit can accordingly be an RFID reader. The identification element can be an RFID tag or RFID chip. The reading unit can preferably also be used to write or modify data in the memory element of the identification element, which can thus be an RFID writing device.

[0043] Alternatively, the monitoring device can be configured as an optical scanning device for detecting the at least one identification element using light. For example, a code (barcode or matrix code) readable by the scanning device is used.

[0044] Particularly when using RFID technology, it is advantageous if the at least one identification element is arranged in the at least one production element and in particular is free from contact with its outer surface and / or is encapsulated in the production element.

[0045] In the last-mentioned advantageous embodiment, it is preferably possible to non-destructively sterilize and / or autoclave the at least one production element with the at least one identification element for it. For the latter purpose, the production element is preferably heat-resistant.

[0046] The production element is preferably subjected to a H2O2 decontamination cycle without damaging the identification element.

[0047] The production element, including the identification element, is preferably resistant to cleaning agents.

[0048] Possible materials for at least one production element include, for example, a sterilizable and / or autoclavable plastic such as PEEK or a pharmaceutical-grade stainless steel, e.g., AISI 316L.

[0049] The system preferably comprises at least one handling device in the processing space, wherein the at least one production element and / or the packaging material can be handled by means of the at least one handling device. The at least one handling device is preferably configured as a robot.

[0050] The system can comprise a storage device for storing a plurality of containers, wherein the storage device is arranged outside the system. For example, containers are prepared for later use with the preparation device mentioned below and stored in the storage device, which for this purpose is designed, for example, as a shelf or includes such a shelf. The position of a respective container in the storage device is preferably stored in the memory unit of the at least one data processing device in order to be able to identify it at a later time.

[0051] The system can comprise a preparation device which is spatially separate from the system and which comprises a work space, wherein a removal opening which can be closed and opened via a closing element is formed in a wall of the preparation device, wherein the container can be docked to the preparation device, and wherein the at least one production element can be transferred from the work space into the interior when the closing elements are open. The at least one container can be equipped with production elements via the preparation device. For this purpose, the at least one production element is transferred through the openings into the docked container. The container can be docked to the preparation device and, in particular, detachably connected to the preparation device. The container is docked to the outside of the preparation device, for example, to a wall of the preparation device.

[0052] For later use, the container is finally closed and undocked and can, for example, be temporarily stored in the optional storage facility.

[0053] Advantageously, the container's status information is updated via the production facility during loading. For example, the storage element stores information about the type of production element accommodated in the interior and its position. It is conceivable, for example, for a receiving body (such as a magazine plate) to be arranged in the interior, with the container's identification element storing information about the position of the receiving body and, if applicable, where a respective production element is located on the receiving body. The receiving body can, for example, have an independent identification element in which the position of a production element on the receiving body is stored.When equipping the container via the preparation device, it is preferably possible to ensure, via at least one reading unit, that the container is equipped correctly, in particular according to a production plan. For example, the status information of respective production elements can be read out, which are only introduced into the container if they are the correct production elements and if they are in the correct condition (e.g. cleaned, sterilized or unused). In this way, a high level of process reliability can be ensured and the production cycle can be reliably traced. Any information for production elements to be introduced into the container and / or concerning the container can be provided, for example, on an information unit of the reading unit or a separate information unit, e.g. on a display.In this way, the user can be guided through equipping the container, for example in a step-by-step guide.

[0054] It can be advantageous if instructions require the user to acknowledge, for example, step by step. Acknowledgment can be made via the instruction unit or via a separate input unit. For example, status information, such as that of the container's identification element, is only written to or updated in the memory element once all actions have been acknowledged by the user. This increases process reliability and ensures the tracking of individual actions.

[0055] The system may include more than one preparation device. The preparation devices may be identical or different.

[0056] The closing elements of the system and / or the preparation device, on the one hand, and of the container, on the other, are preferably standardized. In this case, a standardized port is formed, in particular an RTP (Rapid Transfer Port). The container can be a so-called beta container with a beta port, with the corresponding alpha port being arranged on the system and / or the preparation device.

[0057] The system can preferably comprise a plurality of reading units arranged at different positions within the system. The reading units can be identical or different. The at least one reading unit can be stationary. Alternatively or additionally, at least one movable, in particular user-guided, reading unit is provided.

[0058] For example, a user-controlled reading unit can be located outside the system.

[0059] For example, a reading unit that is user-guided can be arranged in the processing room.

[0060] A reading unit can be arranged or fixed at the at least one processing station.

[0061] For example, a reading unit can be arranged or fixed to the at least one handling device in the processing space. For example, the reading unit is arranged on a tool or end effector of the, for example, robotic handling device. When the container is docked, identification elements of production elements in the interior of the container can be read via this reading unit. For example, it is provided that a production element is only introduced into the processing space if it is the correct production element, in particular according to the production plan, and if it has a specific, specified quality.

[0062] For example, a reading unit is arranged or fixed at the insertion opening, preferably on the outside of the system. This reading unit can advantageously read the identification element of a container docked to the system or to be docked to the system. This ensures, preferably before the closing element is opened, that the correct container with the correct contents is docked. This ensures a high level of process reliability and prevents errors in the production cycle.

[0063] A reading unit can, for example, be arranged or fixed to a receiving element in the processing space for receiving a used or discarded production element.

[0064] If the preparation device is provided, a reading unit, preferably user-guided, can be arranged in the work area, for example. A reading unit can be arranged or fixed to a handling device, particularly a robotic one, in the work area of ​​the preparation device.

[0065] A reading unit can be arranged or fixed at the removal opening, preferably on the outside of the preparation device, whereby the identification element of a container docked to the preparation device or to be docked to the preparation device can be read via the reading unit. In a similar manner to the system, this ensures that the correct container is loaded with production elements. Preferably, the locking elements are only opened once it is ensured that the correct container is docked and is in the intended condition.

[0066] It is understood that with the plurality of reading units, an exchange of information via the at least one data processing device may be possible.

[0067] The status information may, for example, comprise or relate to at least one of the following: an identification number of the production element, which is in particular unique and by means of which the production element can preferably be uniquely identified.

[0068] A part number of the production element. This could be an item number, for example.

[0069] A type of production element.

[0070] A batch of the production element.

[0071] Information concerning the content of the production element in the case of a container as a production element.

[0072] Information concerning the position of another production element in the case of a container that holds the another production element.

[0073] Information regarding the position of another production element in the case of a receiving body that receives the additional production element. Information regarding the geometry of the production element. This information can be taken into account, for example, by the handling device when handling the production element in the processing area.

[0074] Information regarding the installation of the production element in the system, in particular a target position within the system. For example, the handling device is controlled depending on the information regarding the installation of the production element.

[0075] Information concerning the control of the system using the production element in the system.

[0076] Information concerning the processing of packaging materials by the plant using the production element in the plant.

[0077] Information indicating whether the production element has been used or not yet. This makes it possible to increase process reliability. For example, only unused production elements are used and marked as used after use.

[0078] Information that indicates whether the production element, in the case of a container, has been previously opened or not. This allows for increased process reliability. For example, it can be ensured that only unopened containers are docked onto the system. Assuming that the unopened container has the correct level of cleanliness can, for example, prevent the risk of compromising the cleanliness of the processing area.

[0079] Information indicating whether the production element is contaminated or not, for example when used with a toxic product;

[0080] Information as to whether the production element is cleaned or sterilized or not.

[0081] This also allows for increased process reliability. For example, the container is only docked or opened to transfer the production element into the processing room when it is ensured that the production element contained in the container has been sterilized. The relevant status information is preferably stored in the identification element of the container itself.

[0082] A timestamp, for example, for the time of creation and / or the time of a change to the status information. The status information can include the identifier of a facility on or in which the production element is to be and / or was used.

[0083] The status information may include the identification of a preparation device at which the production element was introduced into the container or at which the container was equipped.

[0084] The status information may include a timestamp of the use of the production item.

[0085] The status information may include a timestamp to determine a validated service life in the sterile status.

[0086] Based on the status information of the identification element of at least one container, at least one of the following can be checked during or before docking:

[0087] Is the container the right type?

[0088] Does it contain the correct content (for example, the type of recording body and its contents)?

[0089] Where are the required production elements located? Can the container be opened, or has it already been opened at another facility or in another process?

[0090] Does the container have a free storage space for storing a receiving body?

[0091] What is the status of the container (contaminated / cleaned / sterile)?

[0092] The status data for the contents can, for example, be updated during each loading and / or unloading process. This ensures that the status data remains up-to-date, even if the container is loaded and / or unloaded over multiple docking cycles. To increase process reliability, the locking elements are preferably only opened when all status data is correct or plausible.

[0093] The status information of the receiving body can be stored on the identification element. At least part of the status information can be written into the container's identification element when inserted into the container. This allows the contents of the container to be read from the outside. Possible status information of the receiving body's identification element can include:

[0094] Number of storage locations and / or identification of which storage location is free or occupied;

[0095] Positions of the recorded production elements; which production element is it?

[0096] Dimensions and / or type of production element;

[0097] What is the status of the receiving body (contaminated / cleaned / sterile)?

[0098] The status information about the contents can, for example, be updated every time the container is loaded and / or unloaded.

[0099] The status information of the identification element of a format part can include, for example:

[0100] What type of format part is it?

[0101] What are the features of this type of format part?

[0102] Insertion and removal position for the handling device?

[0103] Dimensions of the format part, for example height and / or diameter; designation of the format part in various languages;

[0104] What is the status of the format part (contaminated / cleaned / sterile)?

[0105] To prevent accidental or deliberate misuse of data, appropriate access rights may be required. For example, there may be password-protected areas and user profiles with different access rights to access the at least one data processing device and / or the identification elements.

[0106] Process reliability can be increased, for example, by reading out test information (e.g. a checksum or similar) as part of the status information.

[0107] The system may comprise a control device that is directly or indirectly coupled to the at least one reading unit, wherein the system can be controlled depending on the determined status information. The data processing device may comprise or form the control device, or the data processing device may be formed separately from the control device and coupled to it.

[0108] Depending on the status information determined, the control device can, for example, control at least one processing station and / or at least one handling device arranged in the processing space for the production element and / or the packaging material.

[0109] Alternatively or additionally, the control device can, for example, control at least one information unit for the user to provide at least one information, depending on the determined status information. The at least one information unit preferably comprises a controllable image display.

[0110] The at least one reading unit may comprise or form the at least one indication unit. Alternatively, the indication unit may be spatially separated from the reading unit.

[0111] For example, a confirmation can be provided at the at least one indication unit in the event that a production element identified on the basis of the status information is a correct production element, in accordance with the production plan, for example when equipping the container via the preparation device.

[0112] For example, an error message can be provided at the at least one information unit in the event that a container is docked to the system or is intended to be docked that does not correspond to the production plan.

[0113] For example, an error message can be provided on the at least one information unit in the event that a container is docked to the system or is intended to be docked that is in a state that deviates from the production plan because, for example, it has been opened and / or is not sterilized or does not contain a non-sterilized production element.

[0114] For example, an error message can be provided on the at least one information unit in the event that a container is docked to the system or is intended to be docked, which does not contain at least one production element provided for in the production plan or does not contain it in a specified state (because, for example, it is not sterilized or has already been used).

[0115] For example, an error message can be provided on the at least one notification unit if the container is docked at an insertion opening on the system or is intended to be docked at a different insertion opening than the one provided for in the production plan. For example, the system has multiple insertion openings with respective closing elements, whereby the container is to be docked at a specific insertion opening. An error message can be issued if docking has occurred or is planned at the wrong insertion opening.

[0116] For example, a confirmation can be provided at the at least one notification unit when a container is docked at the facility or is scheduled to be docked that is in accordance with the production plan. If all requirements are met, this is preferably acknowledged.

[0117] The system can be provided with at least one self-propelled and self-steering transport device for receiving at least one container, wherein the container can be autonomously docked to and decoupled from the system via the transport device. This makes the system highly versatile. For example, a container can be transported via the transport device from the preparation device to the storage device and from there to the system during use.

[0118] The at least one transport device preferably comprises at least one reading unit, or such a unit is arranged on the transport device. This allows, for example, identification elements of containers to be read.

[0119] As mentioned at the outset, the present invention also relates to a monitoring device. A monitoring device according to the invention is a monitoring device for a system for processing pharmaceutical packaging of the type described above.

[0120] The monitoring device comprises, in particular, at least one reading unit and at least one identification element. Advantageously, the at least one data processing device is a component of the monitoring device. The control device can be a component of the monitoring device.

[0121] Advantageous embodiments of the monitoring device according to the invention result from the advantageous embodiments of the system according to the invention, as described above.

[0122] As mentioned above, the present invention also relates to a method. A method according to the invention for monitoring a system of the type described above provides that status information of at least one identification element is read out by means of the at least one reading unit.

[0123] The advantages explained in connection with the system according to the invention can also be achieved using the method. Advantageous embodiments of the method result from advantageous embodiments of the system according to the invention. Reference is made to the above explanations.

[0124] The method can, in particular, provide for the system to be controlled based on the status information. When an identification element is placed in the container, its identification element can be written to. When the identification element is removed from the container, its identification element can be updated by changing the status information. Production elements can be marked as used or unused, as cleaned or not cleaned, as sterile or not sterile, etc. Reference is made to the above explanations.

[0125] The following description of preferred embodiments of the invention, taken in conjunction with the drawings, serves to explain the invention in more detail. They show:

[0126] Figure 1: a schematic representation of the system according to the invention in a preferred embodiment;

[0127] Figure 2: a schematic representation of a production element of the system, comprising an identification element and a reading unit;

[0128] Figure 3: a schematic representation of a system for processing pharmaceutical packaging materials as a component of the system of Figure 1; and Figure 4: a schematic representation of a preparation device and a storage device of the system of Figure 1.

[0129] The invention is described below using the example of a preferred embodiment of the system according to the invention, which is designated overall by reference numeral 100. Reference is first made to the above explanations, which particularly describe preferred embodiments of the system and from which advantageous exemplary embodiments of the method emerge. Unless explained below, the optional features of the system described above may be present and implemented in whole or in part in the embodiments presented here.

[0130] The system 100 is used to process pharmaceutical packaging materials 102. Figure 3 shows exemplary containers 104 as the primary packaging materials 102, with the containers being, for example, vials. Other types of containers 104 are conceivable.

[0131] A pharmaceutical product is filled into the containers 104 using a system 106 for processing the packaging 102. The containers 104 are then sealed. The system 106 is part of the system 100.

[0132] As can be seen in particular from Figure 1, the system 100 in the present example comprises, but this is not limiting, a plurality of systems 106, which may be configured identically or differently.

[0133] In addition, the system 100 advantageously comprises at least one preparation device 108, of which several preparation devices 108 are provided in the present example.

[0134] The system 100 comprises at least one transportable container 110, wherein in the present case, several containers 110 are also provided.

[0135] Conveniently, at least one storage device 112 is provided for the containers 110. Furthermore, the system 100 in this case comprises a data processing device 114, which includes a storage unit 116. The data processing device 114 is spatially separated from the systems 106 and can, for example, comprise one or more servers. A configuration using a schematically illustrated cloud 118 is conceivable.

[0136] The respective system 106 comprises a control device 120, which may be a component of the data processing device 114 or may be formed by the data processing device 114. In this example, the control device 120 is coupled to the data processing device 114 for data exchange.

[0137] At the system 100, the packaging materials 102 are processed in the system 106. The system 106 comprises a chamber 122 having a wall 124 and a processing space 126 enclosed by the wall 124. At least one insertion opening 128 is formed in the wall 124, which can be closed by a closing element 130 arranged thereon or can be opened when the closing element 130 is open. In the present case, two insertion openings 128 and closing elements 130 are shown schematically in Figure 3.

[0138] A first handling device 132 is arranged in the processing space 126. In this case, the handling device 132 is configured robotically, for example, as a multi-axis robot. The handling device 132 has a tool 134 for handling production elements and packaging materials 102.

[0139] A first processing station 136 is a filling station 137, where the containers 104 can be filled with the pharmaceutical product. For this purpose, the containers 104 can be held in a holder 138. A receiving element 140 can serve for temporarily storing the containers 104.

[0140] In this case, the system 106 comprises a second handling device 142, which can preferably be identical to the handling device 132 and, in particular, can be configured robotically. The handling device 142 comprises a tool 144.

[0141] A closing station 147 is provided as a second processing station 146, with which the containers 104 can be closed after filling. For this purpose, the containers 104 can be held on a holder 148. A further receiving element 150 can be used to temporarily deposit the containers 104. When the system 106 is in use, the packaging materials 102 and a container for the product are introduced into the processing chamber 126, for example, via the insertion opening 128. The containers 104 are filled, then closed, and removed from the processing chamber 126 again via an opening, for example, the insertion opening 128.

[0142] To control and manage the processing of packaging materials 102, a production plan 152 is stored, for example, in the storage unit 116. The production plan 152 stores, for example, which packaging materials 102 are filled with which product, in which system 106 this takes place, and which production elements 154 are to be used.

[0143] Production elements 154 can be the packaging materials 102 themselves. Further

[0144] Production elements include, for example, format parts 156, which are used in the system 106 and have container-specific properties.

[0145] Furthermore, machine parts, for example, can be provided as production elements 154, for example as a component of the handling device 132, 142.

[0146] In the present example, the containers 110 are provided as further production elements 154, which remain outside the system 106 but are used during production and can in turn accommodate other types of production elements 154, such as the format parts 156.

[0147] In the present example, further production elements 154 are receiving bodies 158, in particular in the form of magazine plates, which are arranged in a pull-out manner in the container 110 and in turn serve to temporarily receive further production elements 154, for example the format parts 156.

[0148] The production element 154 can, for example, be a filling element used to fill the containers 104 with the product to be filled. This includes, for example, a container for the product, a fluid line, or a filling needle for filling the product into the containers 104.

[0149] In the drawing, reference numeral 156 designates two format parts, using the example of which the invention will be further explained below. Reference numeral 162 designates a magazine plate. In order to monitor the production cycle and thereby increase process reliability, particularly with regard to compliance with the production plan 152, the system 100 comprises the monitoring device 164 according to the invention in a preferred embodiment. In the present example, the monitoring device 164 comprises a plurality of reading units 166 and further identification elements 168, which are included in the respective production elements 154.

[0150] The reading units 166 allow the contactless reading of status information stored in a memory element 170 of the identification element 168. In this case, the reading units 166 are radio-based using electromagnetic radiation. The reading units 166 are, in particular, RFID readers 172, which in the present example are also designed as RFID writing devices, so that the status information can not only be read but also, at least partially, modified. Accordingly, the respective memory element 170 can be written with new status information, or existing status information can be modified. The identification elements 168 are RFID tags 174 or RFID chips.

[0151] Figure 2 schematically illustrates a production element 154 with identification element 168. The identification element 168 is received in the production element 154, for example, potted therein or positioned in a sealed receptacle of the production element 154, so that it is free from contact with the outer surface of the production element 154.

[0152] The production element 154 is in particular sterilizable and / or autoclavable, non-destructive to the identification element 168. The production element 154 can be subjected to an H2O2 decontamination cycle, non-destructive to the identification element 168.

[0153] The monitoring device 164 can track the production elements 154 and monitor their respective status, preferably throughout the entire production cycle. This allows process reliability to be significantly increased using the monitoring device 164 in the system 100. Possible advantages achieved by the invention can include, for example: process reliability, particularly through unmanned production and continuous tracking of the production elements 154; more efficient production, particularly through automated logistics and / or automated transport for required production elements 154. For example, the transport of containers 110 with correct production elements 154 in the correct condition, particularly sterilized, can be mentioned, with the containers 110 being made available to a respective system 106 at the right time.

[0154] Timely identification of any bottlenecks in the inventory of production elements 154.

[0155] Tracking preferably across the entire life cycle and supply chain, for example, from the supplier through production to delivery and disposal. Recording inventory changes in production elements 154 and balancing them through preferably automated ordering processes for improved warehouse management and production planning.

[0156] Monitoring correct production and material flow.

[0157] Transparency and traceability with regard to warehouse management regarding storage locations, storage costs, routes and positions of production elements 154.

[0158] - Automatic picking can be provided.

[0159] Digitization of production.

[0160] Preparation of reports with a view to preferably complete documentation of the production process.

[0161] Identification of production elements 154 and / or contents of containers 110 without insight or visual contact.

[0162] The preparation device 108, which serves to prepare the production process, comprises a chamber 176 having a wall 178 and a work space 180 enclosed by the wall 178. At least one removal opening 182 is formed in the wall 178. The removal opening 182 can be selectively closed or opened by means of a closing element 184.

[0163] The preparation device 108 can have a glove opening 186 for the user to insert, two of which are shown here.

[0164] Alternatively or additionally, the preparation device 108 may comprise a controllable robotic handling device, which may, for example, have a reading unit 166 on the tool, as is the case with the handling devices 132, 142. Via this reading unit 166, status data of the identification elements 168 of production elements 154 can be read and, if necessary, modified.

[0165] For example, a receiving element 188 for production elements 154 can be provided in the working space 180.

[0166] In the present case, the monitoring device 164 comprises a user-guided reading unit 190 in the work space 180. A further reading unit 166 can be arranged on the receiving element 188 in order to read out status information of the production elements 154 stored thereon.

[0167] Advantageously, a reading unit 166 is arranged stationary on the outside of the preparation device 108, for example in the area of ​​the removal opening 182, in order to read out status information of a container docked thereto or of a container 110 to be docked thereto.

[0168] Prior to production, required production elements 154 can be retrieved from a storage facility 192 of the system 100, for example, in accordance with the production plan 152 and brought into the work space 180 for the preparation of a container 110. For the sake of simplicity, it is assumed that the production elements 154, in this case in the form of the format parts 156, have already been sterilized.

[0169] Status information is stored in the respective memory elements 170, which in the present example includes in particular the following: identification number, part number, part type, batch number, information about the geometry, identification as a sterilized production element 154, identification as an unused production element 154, information regarding a target position in the system 106, and any information for controlling the handling device 132, 142. Further possible status information has already been explained above; reference is made to these explanations.

[0170] For preparation, a container 110 is docked to the preparation device 108. In particular, the container 110 is docked externally to the wall 178. The identification element 168 of the container 110 is read via the reading unit 166 located outside the removal opening 182. In particular, its identification number is recorded, and it is also determined whether it has the required purity. A closing element 194, which closes a container opening 196, is opened, as is the closing element 130 for the removal opening 182.

[0171] The closure elements 130 and / or 184 on the one hand, and 194 on the other, are preferably standardized. In particular, a standardized port is formed, in particular an RTP (Rapid Transfer Port). Accordingly, the container 110 can be a so-called beta container with a beta port, with the corresponding alpha port being arranged at the openings 128, 182.

[0172] Production elements 154 can be introduced into the container 110 when the closing elements 184 and 194 are opened and an interior space 198 of the container 110 communicates with the working space 180.

[0173] The user adds the required format parts 156 to the interior 198 of the container 110 according to the specification in the production plan 152. This occurs, for example, by removing the format parts 156 from the receiving element 188, which can be detected by its reading unit 166. By reading the identification elements 168, e.g., via the hand-held reading unit 190, it can be ensured that the correct format part 156 is present. Confirmation of this can be output at an indication unit 200 of the reading unit 190 or at a separate indication unit 202. The indication units 200, 202 preferably have a controllable image display.

[0174] The format part 156 is placed on a designated position of the magazine plate 162. The identification element 168 of the container 110 is described or updated to indicate the position of the magazine plate 162 in the container 110 and the position of the magazine plate 162 where a respective format part 156 is located.

[0175] Once the loading process is complete, the preparation device 108 and the container 110 are closed. The identification element 168 of the container 110 stores the information that the container is unopened and sterile. A timestamp of the change can be used, for example, to determine a sterility retention period.

[0176] The data processing device 114 stores the status information of all identification elements 168 as well as the changes to this status information, which are logged accordingly. The sealed container 110 can be undocked from the preparation device 108.

[0177] If the container 110 is not immediately brought to the facility 106, it can be temporarily stored in the storage facility 112. The storage facility 112 comprises, for example, a shelf 110 for a plurality of containers 110.

[0178] If the container 110 is used at a later time, it can be located, for example, by means of a reading unit 206 arranged externally to the system 106 and the preparation device 108. For this purpose, the identification elements 168 of the container 110 can be read to identify the appropriate container 110.

[0179] For use with the system 106, the container 110 can be docked. In particular, the container 110 is docked externally to the wall 124. A stationary reading unit 166 is preferably arranged on the outside of the wall 124, for example, in the region of the insertion opening 128. This allows the identification element 168 of the container 110 to be read, preferably automatically and / or before the container 110 and the system 106 are opened.

[0180] This serves, for example, to ensure that at least one of the following is verified or checked: selection of the correct container 110, arrangement of the container 110 at the correct insertion opening 128, in particular verification of the correct contents of the container 110, checking whether the production elements 154 accommodated in the interior 198 have the correct condition, for example are sterilized and / or unused.

[0181] Production elements 154 can be transferred from the container 110 into the processing space 126 when the closing elements 130 and 194 are opened and the interior space 198 communicates with the processing space 126.

[0182] Only when all requirements stipulated in the production plan 152 are met is the container 110 opened and the system 106 opened by opening the respective closing elements 130, 194. In the event of any errors, deviations from the production plan 152, or malfunctions, a notification is preferably sent to the user, for example via a notification unit 200, 202.

[0183] Depending on the status information read from the container 110, the system 106 can be controlled via the control device 120. For example, information is transmitted to the handling device 132 regarding which format parts 156 can be found at which position on the magazine plate 162.

[0184] By means of a reading unit 166 on the tool 134, the identification elements 168 of the format parts 156 can be read, preferably before insertion into the processing chamber 126. Once it is ensured that they are the correct format parts 156, the handling device 132 grips the format parts 156 and guides them to the intended target position in the processing chamber 126. In addition to the correctness of the format part 156, it is checked in particular whether it has already been used and / or sterilized.

[0185] Any intermediate storage of production elements 154 can take place on the receiving elements 140, 150. Preferably, a reading unit 166 is provided on each of these to detect the presence of the production elements 154.

[0186] In addition, a hand-held reading unit 208 can be present in the processing space 126, which the user can guide, for example, via a glove opening 186.

[0187] The format parts 156 that have been introduced into the processing chamber 126 are preferably marked as used. This can be done, for example, by updating the status information via the reading unit 166 of a handling device 132, 142, although a different reading unit 166 or 208 could also be used.

[0188] After production, the format parts 156 can be removed from the processing chamber 126 and disposed of or sent for further processing. The format parts 156 can be accommodated in the interior space 198 of the container 110.

[0189] After the process is completed, the container 110 can be undocked from the system 106. In particular, the container 110 is sealed beforehand. The system 106 can include a further reading unit 166, for example, on the floor 210 of the processing chamber 126, which can serve to receive rejected production elements 154 (so-called reject plate). The status information for these production elements 154 can be updated to "rejected" or "sorted out."

[0190] The read-out status information can be used to control, in particular, the system 106, for example a handling device 132, 142 and / or one of the processing stations 136, 146.

[0191] After the production cycle, the data processing device 114 can create a report 212 containing all information relevant to production. To create the report 212, the stored and logged status information is evaluated. The report 212 can be linked to the batch of the manufactured pharmaceutical product.

[0192] Furthermore, report 212 may include an evaluation of which production elements 154 were used or consumed and how frequently they were used. In conjunction with the aforementioned procurement of production elements 154 and preferably automated warehouse management, this results in particular in the advantages of condition monitoring and predictive maintenance of system 100.

[0193] It may be advantageous if procurement information is transmitted from the data processing device 114 to a spatially remote delivery device 214, preferably automatically, in order to replenish the inventory of the storage facility 192.

[0194] It has already been mentioned that different types of memory sections can be present in the memory element 170. It is particularly conceivable that a memory section is present that can only be read. At least one memory section whose content can be modified can be provided. It is also conceivable that the reading of status information and / or the changing of status information in the respective memory section is only possible using a specific reading unit 166. Furthermore, it can be provided that different types of status information are stored in different memory sections. For example, there is a memory section for manufacturer-side status information of the production element 154 and a memory section for customer-side or user-side status information of the production element 154.

[0195] The system 100 may include a mobile transport device 216. Multiple transport devices 216 may be provided.

[0196] The transport device 216 is preferably self-propelled and self-steering and is designed for the autonomous transport, in particular of containers 110. It is advantageous if a reading unit 166 is arranged on the transport device 216.

[0197] The transport device 216 is preferably coupled to the data processing device 114 and / or a control device 120. The transport device 216 is activated as needed, in particular for transporting production elements 154. For example, the production elements 154 are fed to the preparation device 108. In this case, the movement of the containers 110 is particularly conceivable. Equipped containers 110 can be transported by the transport device 216, for example, to the storage device 112 or directly to the system 106. Intermediately stored containers 110 can be picked up from the storage device 112 and transported to the respective system 106.

[0198] List of reference symbols

[0199] system

[0200] Packaging, 110 containers

[0201] Attachment

[0202] Preparation facility

[0203] Storage facility

[0204] Data processing facility

[0205] storage unit

[0206] Cloud

[0207] Control device, 176 chamber, 178 wall

[0208] processing room

[0209] Insertion opening, 184, 194 Closing element, 142 Handling device, 144 Tool, 146 Processing station

[0210] Filling station, 148 Bracket, 150, 188 Holding element

[0211] Closing station

[0212] Production plan

[0213] Production element

[0214] Format part

[0215] Receiving body

[0216] Magazine plate

[0217] Monitoring device, 190, 206, 208 reading unit

[0218] Identification element

[0219] storage element

[0220] RFID reader

[0221] RFID tag

[0222] Work area Removal opening Glove opening Storage facility Container opening Interior , 202 Information unit Shelf Floor Report Delivery facility T ransport facility

Claims

PATENT CLAIMS 1. System (100) for processing pharmaceutical packaging (102), comprising: a system (106) for processing the packaging (102), which system comprises a processing space (126) and at least one processing station (136, 146) for the packaging (102) arranged in the processing space (126), wherein an insertion opening (128) which can be closed and opened via a closing element (130) is formed in a wall (124) of the system (106); a transportable container (110) comprising an interior space (198) for receiving at least one pharmaceutical production element (154) and a container opening (196) which can be closed and opened via a closing element (194), wherein the container (110) can be docked to the system (106), wherein the at least one production element (154) comprises a production element (154) which can be transferred from the interior space (198) into the processing space (126) when the closing elements (130, 194) are open, and a monitoring device (164),which comprises at least one reading unit (166, 190, 206, 208) and at least one identification element (168) which is arranged on or encompassed by the at least one production element (154), wherein status information about the production element (154) is stored on or in the at least one identification element (168), in particular stored in a memory element (170) of the identification element (168), wherein the status information can be read out contactlessly by means of the at least one reading unit (166, 190, 206, 208).

2. System (100) according to claim 1, characterized in that the system (100) comprises at least one data processing device (114) with a storage unit (116) in which status information of the at least one production element (154) is stored, in particular linked to a production plan (152) relating to the processing of the packaging means (102) and / or the planned use of the at least one production element (154) in the system (106).

3. System (100) according to claim 2, characterized in that changes in the status information of the at least one production element (154) can be stored in the storage unit (116).

4. System (100) according to claim 2 or 3, characterized in that the at least one data processing device (114) can create a report (212) on the use of the at least one production element (154) on the basis of the status information.

5. System (100) according to one of claims 2 to 4, characterized in that a report (212) on the processing of the production plan (152) can be created by the at least one data processing device (114).

6. System (100) according to one of claims 2 to 5, characterized in that procurement information for procuring further production elements (154) can be transmitted from the at least one data processing device (114) to a spatially remote delivery device (214) depending on the use and / or consumption of the at least one production element (154).

7. System (100) according to one of claims 2 to 6, characterized in that the at least one reading unit (166, 190, 206, 208) forms the at least one data processing device (114), or the at least one data processing device (114) is formed separately from the at least one reading unit (166, 190, 206, 208) and coupled thereto.

8. System (100) according to one of claims 2 to 7, characterized in that Information can be transmitted wirelessly between the at least one data processing device (114) and the at least one reading unit (166, 190, 206, 208).

9. System (100) according to one of the preceding claims, characterized in that the status information of the at least one identification element (168) can be changed, in particular by means of the at least one reading unit (166, 190, 206, 208).

10. System (100) according to one of the preceding claims, characterized in that the memory element (170) of the at least one identification element (168) comprises two or more memory sections which differ from one another in terms of their nature, wherein in particular a memory section is provided whose content can only be read out and / or a memory section whose content can be read out and changed or which can be written to.

11. System (100) according to one of the preceding claims, characterized in that the at least one production element (154) is or comprises at least one of the following: a format part (156) of the system (106), wherein different format parts (156) differ from one another by at least one packaging-specific property; a machine part, for example of the at least one processing station (136, 146); a receiving body (158) for temporarily receiving a different type of production element (154), in particular in the interior (198) of the container (110); a pharmaceutical packaging (102); a filling element that is used when filling the packaging (102) with a product.

12. System (100) according to one of the preceding claims, characterized in that the container (110) is a pharmaceutical production element (154) and comprises an identification element (168) readable by the at least one reading unit (166, 190, 206, 208).

13. System (100) according to one of the preceding claims, characterized in that the monitoring device (164) is designed to read the at least one identification element (168) using radio-based electromagnetic radiation, in particular using RFID.

14. System (100) according to one of claims 1 to 12, characterized in that the monitoring device (164) is designed as an optical scanning device for detecting the at least one identification element (168) by means of light.

15. System (100) according to one of the preceding claims, characterized in that the at least one identification element (168) is arranged in the at least one production element (154), in particular free from contact with its outer surface and / or encapsulated.

16. System (100) according to one of the preceding claims, characterized in that the at least one production element (154) with the at least one identification element (168) is non-destructively sterilizable and / or autoclavable.

17. System (100) according to one of the preceding claims, characterized in that the system (100) comprises at least one handling device (132, 142) in the processing space (126), wherein the at least one production element (154) and / or the packaging means (102) can be handled by means of the at least one handling device (132, 142), wherein the at least one handling device (132, 142) is designed in particular to be robotic.

18. System (100) according to one of the preceding claims, characterized in that the system (100) comprises a storage device (112) for storing a plurality of containers (110).

19. System (100) according to one of the preceding claims, characterized in that the system (100) comprises a preparation device (108) which is spatially separate from the system (106) and which comprises a working space (180), wherein a removal opening (182) which can be closed and opened via a closing element (184) is formed in a wall (178) of the preparation device (108), wherein the container (110) can be docked onto the preparation device (108), and wherein the at least one production element (154) can be transferred from the working space (180) into the interior (198) when the closing elements (184, 194) are open.

20. System (100) according to one of the preceding claims, characterized in that the system (100) comprises a plurality of reading units (166, 190, 206, 208) arranged at different positions of the system (106).

21. System (100) according to one of the preceding claims, characterized in that the at least one reading unit (166, 190, 206, 208) is stationary and / or that at least one movable, in particular user-guided, reading unit (166, 190, 206, 208) is provided.

22. System (100) according to one of the preceding claims, characterized in that a reading unit (166, 190, 206, 208) is arranged or fixed at at least one of the following positions: outside the system (106), wherein the reading unit (166, 190, 206, 208) is user-guided; in the processing room (126), wherein the reading unit (166, 190, 206, 208) is user-guided; at the at least one processing station (136, 146); at the at least one handling device (132, 142) in the processing room (126); at the insertion opening (128), preferably on the outside of the system (106), wherein the identification element (168) of a container (110) docked to the system (106) or to be docked to the system (106) can be read out via the reading unit (166, 190, 206, 208); on a receiving element (140, 150, 188) in the processing space (126) for receiving a used or discarded production element (154); in the working space (180) of the preparation device (108), wherein the reading unit (166, 190, 206, 208) is preferably user-guided; on a handling device in the working space (180) of the preparation device (108); at the removal opening (182) of the preparation device (108), preferably on the outside of the preparation device (108), wherein the identification element (168) of a container (110) docked to the preparation device (108) or to be docked to the preparation device (108) can be read via the reading unit (166, 190, 206, 208).

23. System (100) according to one of the preceding claims, characterized in that the status information comprises or relates to at least one of the following: an identification number of the production element (154), which is in particular unique; a part number of the production element (154); a type of the production element (154); a batch of the production element (154); information concerning the contents of the production element (154) in the case of a container (110) as the production element (154); information concerning the position of a further production element (154) in the case of a container (110) that receives the further production element (154); information concerning the position of a further production element (154) in the case of a receiving body (158) that receives the further production element (154); information concerning the geometry of the production element (154);information relating to the installation of the production element (154) in the system (106), in particular a target position in the system (106); information relating to a control of the system (106) using the production element (154) in the system (106); information relating to processing of the packaging means (102) by the system (106) using the production element (154) in the system (106); information indicative of whether the production element (154) has been used or not yet; information indicative of whether the production element (154), in the case of a container (110), has been previously opened or not; information indicative of whether the production element (154) is contaminated or not; information as to whether the production element (154) has been cleaned or sterilized or not; a timestamp.

24. System (100) according to one of the preceding claims, characterized in that the system (106) comprises a control device (120) which is directly or indirectly coupled to the at least one reading unit (166, 190, 206, 208), and in that the system (106) can be controlled depending on the determined status information.

25. System (100) according to claim 24, characterized in that the data processing device (114) comprises or forms the control device (120) or that the data processing device (114) is coupled to the control device (120).

26. System (100) according to claim 24 or 25, characterized in that at least one processing station (136, 146) can be controlled by the control device (120).

27. System (100) according to one of claims 24 to 26, characterized in that at least one handling device (132, 142) arranged in the processing space (126) for the production element (154) and / or the packaging means (102) can be controlled by the control device (120).

28. System (100) according to one of claims 24 to 27, characterized in that at least one information unit (200, 202) for the user can be controlled by the control device (120) to provide at least one information, in particular comprising a controllable image display.

29. System (100) according to claim 28, characterized in that at least one of the following can be provided on the at least one indication unit (200, 202): a confirmation in the event that a production element (154) identified on the basis of the status information is a correct production element (154) in accordance with the production plan; an error indication in the event that a container (110) is docked to the system (106) or is intended for docking that does not correspond to the production plan (152); an error indication in the case that a container is docked to the system (106) or is intended for docking that assumes a state that deviates from the production plan (152);an error message in the event that a container (110) is docked to the system (106) or is intended for docking, which does not contain at least one production element (154) provided in the production plan (152) or does not contain it in a predetermined state; an error message in the event that the container (110) is docked to the system (106) at an insertion opening (128) or is intended for docking, deviating from an insertion opening (128) provided in the production plan (152); a confirmation if a container (110) is docked to the system (106) or is intended for docking that is in accordance with the production plan (152); 30. System (100) according to one of the preceding claims, characterized in that the system (100) comprises at least one self-propelled and self-steering transport device (216) for receiving at least one container (110), wherein the container (110) can be docked autonomously to and decoupled from the system (106) via the transport device (216).

31. System (100) according to claim 30, characterized in that the at least one transport device (216) comprises at least one reading unit (166, 190, 206, 208) or that such a unit is arranged on the transport device (216).

32. Monitoring device (164) for a system (100) for processing pharmaceutical packaging materials (102) according to one of the preceding claims.

33. A method for monitoring a system (100) according to one of the preceding claims, wherein status information of at least one identification element (168) is read out by means of the at least one reading unit (166, 190, 206, 208).

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