Disinfectant composition and its uses.

Abstract

The present invention relates to a new disinfectant composition comprising: A) from 0.1 to less than 10% by weight of propionic acid, relative to the total weight of the disinfectant composition, B) at least one linear or branched aliphatic or cycloaliphatic diol having from 4 to 8 carbon atoms, C) at least one surfactant selected from anionic, nonionic, amphoteric, glycolipidic surfactants, and mixtures thereof, and D) water, said disinfectant composition having a pH greater than 2.0 and less than the pKa of propionic acid, which is 4.87. This composition is particularly useful for disinfecting the udders and teats of an animal, before or after milking, as well as for disinfecting surfaces such as open surfaces.

Description

Title of the invention: Disinfectant composition and its uses. technical field

[0001] The present invention relates to a novel disinfectant composition or biocidal composition comprising propionic acid and at least one diol, particularly useful for disinfecting the udders and teats of an animal, before or after milking, as well as for disinfecting surfaces such as open surfaces. The present invention relates in particular to a disinfectant composition compatible with European Regulation (EU) No 528 / 2012, also known as the "Biocidal Products Regulation," which governs the rules relating to the placing of biocidal products on the market. According to Article 25 of this Regulation, a biocidal product is eligible for the Simplified Marketing Authorisation (SMA) procedure if the following conditions are met: - the active substances present in the biocidal product are chosen from those authorized in European Regulation (EU) No 528 / 2012 (Annex I) and comply with all specified restrictions, - The biocidal product does not contain substances of concern for humans and the environment. - The biocidal product does not contain nanomaterials, - the biocidal product is sufficiently effective, and - Handling and use of the biocidal product do not require personal protective equipment. Previous technique

[0002] Patent EP 3 677 867 B1 describes plant-based biocidal products comprising at least one organic acid, a chelating agent, a mixture of nonionic and anionic surfactants, and a natural fragrance. All these compositions are based on lactic acid. In their concentrated form, these products are irritating to the skin and can cause serious eye damage.

[0003] French patent FR 3019714B1 describes a concentrated, biodegradable biocidal formulation based on lactic acid and / or citric acid, in combination with at least one sodium and / or potassium carboxylate. Such a formulation is classified as an irritant according to current regulations.

[0004] In March 2022, the classification of lactic acid changed. This raw material is now labeled H314 - H318 (H314: causes skin burns and eye damage, H318: causes serious eye damage). The presence of lactic acid in biocidal products poses current challenges labeling problems.

[0005] Indeed, obtaining a Simplified Marketing Authorisation (AMMS) for a biocidal product requires meeting the following objectives (i) to (iv): (i) No risk phrases H314 (causes skin burns and eye damage), H315 (causes skin irritation), H317 (may cause skin irritation), H318 (causes serious eye damage), or H319 (causes serious eye irritation) should appear on the label of the biocidal product. Therefore, the active substances listed in Annex I that fall under this classification should be used at concentrations that do not require product labeling. The handling and use of the biocidal product should not require personal protective equipment. (ii) The choice of the active substance(s) must be made from among the active substances listed in categories 1 to 7 of Annex I of European Regulation (EU) No 528 / 2012: Category 1: substances authorized as food additives under Regulation (EC) No 1333 / 2008 with restrictions (the concentration must be limited to avoid classification as biocidal products according to Directive 1999 / 45 / EC or Regulation No 1272 / 2008), Category 2: substances listed in Annex IV of Regulation (EC) No 1907 / 2006, Category 3: weak acids, Category 4: substances of natural origin traditionally used, Category 5: pheromones, Category 6: substances listed in Annex I or IA of European Regulation (EU) No 528 / 2012, Category 7: other substances. (iii) Additional components present in the biocidal product must be used at concentrations which do not result in classification according to the criteria of European Regulation No. 1272 / 2008. (iv) The disinfectant efficacy of the biocidal product must be equivalent to that of conventional biocidal products, according to the efficacy tests indicated in the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation - ECHA, Volume II Efficacy - Evaluation and Assessment (Parts B + C). Furthermore, the biocidal product must meet an additional objective (v), namely that its properties (cleaning, foaming, cosmetic, rheological, depending on the intended application) must be equivalent to or superior to those of existing biocidal products.

[0006] The solutions proposed to meet objectives (i) to (v) listed above are often conflicting, making it difficult for a biocidal product to simultaneously satisfy all of these requirements. For example, the use of substances aggressive actives against microorganisms or in high concentrations to achieve the required disinfectant efficacy (objective (iv)) is not favorable to objective (i).

[0007] It has been discovered, and this forms the basis of the present invention, that it is possible to simultaneously achieve objectives (i) to (v) listed above by using specific components, and in particular by combining propionic acid and a linear or branched aliphatic or cycloaliphatic diol having 4 to 8 carbon atoms, which will be defined below. By virtue of the choice of these specific constituents, the disinfectant composition of the invention exhibits high microbiological efficacy (bactericidal and yeasticidal activity), while containing neither substances of concern to humans and the environment, nor nanomaterials (unlabeled composition). Thus, the disinfectant composition of the invention can be handled without personal protective equipment.

[0008] Thus, the disinfectant composition of the invention meets the requirements for udder hygiene in an animal before and after milking subjected to AMMS. It is also usable for applications on open surfaces. Description of the invention

[0009] Thus, a first object of the invention relates to a disinfectant composition comprising: A) from 0.1 to less than 10% by weight of propionic acid, relative to the total weight of the disinfectant composition, B) at least one diol with an aliphatic or cycloaliphatic chain, linear or branched, having from 4 to 8 carbon atoms, C) at least one surfactant selected from anionic, non-ionic, amphoteric, glycolipid surfactants, and mixtures thereof, and D) water, said disinfectant composition having a pH greater than 2.0 and less than 4.87.

[0010] A second object of the invention relates to the use of a composition as described above for disinfecting the udders and teats of an animal, before or after milking. The use of a composition as described above for disinfecting surfaces is also part of the invention.

[0011] Another object of the invention relates to a method of disinfecting the udders and teats of an animal before or after milking, comprising at least one step of applying a composition according to the invention to the udders and teats of the animal, before and / or after milking the animal.

[0012] Finally, a last object relates to a method for disinfecting a surface, comprising a step of applying a composition according to the invention to the surface to be disinfected. infect. Detailed description

[0013] Thus, the first object of the invention relates to a disinfectant composition comprising: A) from 0.1 to less than 10% by weight of propionic acid of formula CH3CH2COOH, relative to the total weight of the disinfectant composition, B) at least one diol with an aliphatic or cycloaliphatic chain, linear or branched, having from 4 to 8 carbon atoms, C) at least one surfactant selected from anionic, non-ionic, amphoteric, glycolipid surfactants, and mixtures thereof, and D) water, said disinfectant composition having a pH greater than 2.0 and less than 4.87, the limit of 4.87 corresponding to the pKa value of propionic acid.

[0014] Propionic acid A) present in the composition may advantageously represent from 0.1 to 5%, and more preferably from 1 to 5%, by weight relative to the total weight of the disinfectant composition.

[0015] The diol B) present in the composition is advantageously chosen from 1,2-hexanediol, 2-methyl-1,3-propanediol, meso-2,3-butanediol, isopentyldiol, 1,6-hexanediol, 1,2-pentanediol, 1,4-cyclohexanedimethanol, and mixtures thereof, and preferably from 1,2-hexanediol, 1,6-hexanediol, and mixtures thereof.

[0016] In another particular embodiment, the diol B) is a vicinal diol with an aliphatic or cycloaliphatic chain, linear or branched, having 4 to 6 carbon atoms, and more particularly 1,2-hexanediol.

[0017] The diol B) advantageously represents from 0.1 to less than 10%, and preferably from 1 to 8%, by weight relative to the total weight of the disinfectant composition.

[0018] The disinfectant composition of the invention also comprises at least one surfactant selected from anionic, nonionic, amphoteric, glycolipidic surfactants, and mixtures thereof. Surfactant C) is advantageously selected from anionic, nonionic surfactants, and mixtures thereof.

[0019] When the surfactant C) is an anionic surfactant, it is advantageously chosen from alkyl sulfonate salts, olefin sulfonate salts, paraffin sulfonate salts, glucoside sulfonate salts, alkyl sulfate salts, alkyl ether sulfate salts, alkyl taurate salts, acyl glutamate salts, alkyl ether carboxylic acids and their salts and mixtures thereof, and preferably sodium lauryl glucoside hydroxypropyl sulfonate, sodium decyl glucoside hydroxypropyl sulfonate, sodium 2-ethylhexyl sulfate, sodium n-octyl sulfate, sodium lauryl sulfate, sodium laureth sulfate, methyl cocoyl Sodium taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium capryloyl glutamate, capryleth-9 carboxylic acid, possibly in mixtures with buteth-2 carboxylic acid, laureth-11 carboxylic acid, and mixtures thereof. The most preferred anionic surfactants are sodium n-octyl sulfate, sodium 2-ethylhexyl sulfate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium capryloyl glutamate, and mixtures thereof.

[0020] When the surfactant C) is a nonionic surfactant, it is advantageously chosen from sorbitan esters, glycerol esters, polyglycerol esters, alkyl polyglucosides, alkyl polypentosides, alkanoyl lactyl lactate, ethoxylated alcohols, ethoxylated castor oils, and mixtures thereof, and preferably sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioctanoate, glyceryl caprylate / caprate, polyglyceryl-3 caprylate, polyglyceryl-4 caprate, C10-C16 alkyl polyglucosides, C5 and C10-C12 amyl xylosides, lauryl lactyl lactate, C10 ethoxylated alcohols (preferably with 6 EOs), Ethoxylated castor oils, and their mixtures. The most preferred non-ionic surfactants are sorbitan monooleate, polyglyceryl-4 caprate, C10-C16 alkyl polyglucosides, ethoxylated castor oils (preferably with 33 EO), and their mixtures.

[0021] For the purposes of the invention, the term "alkyl" refers to a saturated aliphatic hydrocarbon group, linear or branched, preferably in C1-C20, and more preferably in C1-C12. The term "branched" means that at least one lower alkyl group such as a methyl or ethyl is borne by a linear alkyl chain.

[0022] When the surfactant C) is an amphoteric surfactant, it is advantageously chosen from sodium lauramphoacetate, sodium 2-ethylhexyl iminodipropionate, and their mixture.

[0023] Surfactant C) advantageously represents from 0.1 to less than 10%, and preferably from 0.1 to 5%, by weight relative to the total weight of the disinfectant composition.

[0024] The disinfectant composition also includes water D), which preferably represents 40 to 99.5%, and more preferably 75 to 95%, by weight relative to the total weight of the disinfectant composition.

[0025] In addition to ingredients A) to D) described above, the disinfectant composition according to the present invention may also comprise at least one moisturizing agent E). Said moisturizing agent E) is preferably selected from polyols other than diol B), hyaluronic acid and its derivatives, alginates, urea, and mixtures thereof, and more preferably from polyols other than diol B) such as those selected from glycerin, propylene glycol, sorbitol, xylitol, erythritol, mannitol, xylose, and mixtures thereof. Glycerin, propylene glycol, and mixtures thereof are the E) moisturizing agents are the most preferred.

[0026] The moisturizing agent E) advantageously represents 0 to 30%, and preferably 1 to 20%, by weight relative to the total weight of the disinfectant composition.

[0027] The disinfectant composition of the invention may also include at least one pH regulating agent (F), the nature and quantity of which are chosen such that said composition has a pH greater than 2.0 and less than the pKa of propionic acid, which is 4.87. The pH regulating agent of the invention may be: - either an acid such as hydrochloric acid and sulfuric acid, and preferably hydrochloric acid, - either a base such as sodium hydroxide and potassium hydroxide, and preferably sodium hydroxide.

[0028] The pH of the disinfectant composition of the invention is greater than 2.0 and less than the pKa of propionic acid, which is 4.87. A pH less than 2.0 would automatically classify the disinfectant composition as H318 (causes serious eye damage). In a preferred embodiment of the invention, the pH of the disinfectant composition is greater than 2.1 and less than 4.0, and more preferably greater than 2.3 and less than 3.5.

[0029] The pH regulating agent F) advantageously represents 0 to 1%, preferably 0.01 to 0.5%, and more preferably 0.01 to 0.25%, by weight relative to the total weight of the disinfectant composition.

[0030] The disinfectant composition of the invention may also include one or more excipients selected from: - colorings, and preferably food colorings such as E104 (quinoline yellow), E10 (sunset yellow FCF), E131 (patent blue V), E133 (brilliant blue FCP), and mixtures thereof, - opacifying agents, and preferably acrylic-styrene and styrene-polyvinylpyrrolidone (PVP) type copolymers, - thickening agents, and preferably natural gums such as cellulose, xanthan, acacia, guar, diutan gums, and mixtures thereof.

[0031] The disinfectant composition of the invention is further advantageously free of nanomaterials.

[0032] The disinfectant composition of the invention is in ready-to-use form.

[0033] The disinfectant composition of the invention is advantageously in the form It can be liquid, gel or foam. It can therefore be applied by soaking or spraying.

[0034] Another object of the invention relates to the use of a disinfectant composition according to the invention, for the disinfection of the udders and teats of an animal, before and / or after milking.

[0035] Another use of the disinfectant composition of the invention is for the disinfection of surfaces, and preferably the disinfection of open surfaces.

[0036] Disinfection processes are also part of the invention.

[0037] According to one embodiment, the invention relates to a method for disinfecting the udders and teats of an animal before and / or after milking, said method comprising the steps of: (i) application of a disinfectant composition according to the invention to the udders and teats of the animal, before and / or after milking the animal, then (ii) Optionally, removal of said disinfectant composition from the udders and teats of the animal, preferably by wiping.

[0038] During step (i), the application of the disinfectant composition can be carried out either manually or automatically. In the latter case, the application can be carried out using a milking robot or an automated system.

[0039] When step (i) of application is carried out before milking the animal, the contact time of the disinfectant composition on the udders and teats of the animal varies preferably from 30 seconds to 3 minutes, and more preferably from 30 seconds to 1 minute and 30 seconds.

[0040] When step (i) of application is carried out after milking the animal, the contact time of the disinfectant composition on the udders and teats of the animal preferably is at least 5 minutes, and more preferably at least 30 seconds.

[0041] During step (ii), the removal of the disinfectant composition can be carried out by manual wiping (using paper or an individual cloth) or by any other automated system (milking robot).

[0042] When the method of disinfecting the udders and teats of an animal of the invention is implemented before milking, the disinfectant composition is eliminated according to option (ii).

[0043] When the method of disinfecting the udders and teats of an animal of the invention is implemented after milking, the disinfectant composition is not eliminated according to option (ii).

[0044] According to another embodiment, the invention relates to a method for disinfecting a surface comprising a step of applying a disinfectant composition according to the invention to a surface to be disinfected, and preferably to an open surface. The application step can be carried out either manually or automatically. The disinfectant composition can be applied by spraying or in the form of a foam. Furthermore, the application step can be followed by a rinsing and / or drying step.

[0045] In addition to the foregoing provisions, the invention also includes other provisions positions which will emerge from the following additional description, which relates to the preparation of disinfectant compositions of the prior art and according to the invention. Examples

[0046] The disinfectant compositions illustrated in the examples were prepared at room temperature, and the components were added under magnetic or electric stirring at 300 rpm in the order indicated in the detailed formulations below. All percentages indicated are percentages by weight.

[0047] The properties of the disinfectant compositions were then evaluated according to the efficacy tests described below, laid down by the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation - ECHA, Volume II Efficacy - Evaluation and Assessment (Parts B + C):

[0048] Phase 2. Step 1: Suspension tests

[0049] Standard EN 1656 (September 2019): Quantitative suspension test for the evaluation of bactericidal activity of chemical antiseptics and disinfectants used in veterinary medicine. The test method consists of a dilution-neutralization. This method allows the biocidal action of the product to be stopped by the neutralizer at the end of the tested contact time. The neutralizer used consists of Saponin 3.0%, Polysorbate 80 3.0%, Lecithin 0.3%, Sodium Thiosulfate 0.5%, L-Histidine 0.1% (percentages expressed as w / v), supplemented with distilled water. It is sterilized at 121°C for 15 min. The strains tested are Staphylococcus aureus (DMS 799), Escherichia Coli (DMS 682), Streptococcus uberis (DMS 20569). The formulations are diluted to 1% (ineffective concentration), 50% and 80% in distilled water (percentages expressed as V / V). The tests are carried out at 30 ± 1°C. The contact time is 1 min ± 5 seconds for pre-milking products and 5 min ± 10 seconds for post-milking products. The tests are carried out in the presence of an interfering substance: 3 g / L of bovine albumin for the products before milking, which corresponds to low level dirt conditions (sterilization by filtration on a membrane of 0.45 pm porosity) and 10 g / L of skimmed milk powder for the products after milking (sterilization at 121°C for 5 min). Once neutralized, the tested dilutions are deposited on tryptone-soy agar (TSA). The incubation of the strains is carried out at 37 ± 1°C over two cycles of between 20 and 24 hours. The counting technique is a depth count (colony counting). The product being tested must show a reduction of at least 5 decimal log under the test conditions.

[0050] Standard EN 1657 (May 2016): Quantitative suspension test for the evaluation of the fungicidal or yeasticidal activity of chemical antiseptics and disinfectants used in the veterinary field. The test method consists of a dilution-neutralization. This method allows the biocidal action of the product to be stopped by the neutralizer at the end of the tested contact time. The neutralizer used consists of Saponin 3.0%, Polysorbate 80 3.0%, Lecithin 0.3%, Sodium Thiosulfate 0.5%, L-Histidine 0.1% (percentages expressed as w / v), supplemented with distilled water. It is sterilized at 121°C for 15 min. The strain tested is Candida albicans (DMS 1386). The 125% concentrated formulations are diluted to 0.8% (ineffective concentration), 64% and 80% in distilled water (percentages expressed as V / V). The tests are carried out at 30 ± 1°C. The contact time is 1 min ± 5 seconds for pre-milking products and 5 min ± 10 seconds for post-milking products. The tests are carried out in the presence of an interfering substance: 3 g / L of bovine albumin for the products before milking, which corresponds to low level dirt conditions (sterilization by filtration on a membrane of 0.45 pm porosity) and 10 g / L of skimmed milk powder for the products after milking (sterilization at 121°C for 5 min). Once neutralized, the tested dilutions are placed on malt extract agar (MEA). The strains are incubated at 30 ± 1°C for two cycles of between 20 and 24 hours. The counting technique is a depth count (colony counting). The product being tested must show a reduction of at least 4 decimal log under the test conditions.

[0051] Phase 2. Step 2: Surface tests Draft standard EN 17422 (June 2020): Quantitative surface test for the evaluation of teat disinfectants used in veterinary medicine - Test specific to bactericidal activity The test method consists of a dilution-neutralization. This method allows the biocidal action of the product to be stopped by the neutralizer at the end of the tested contact time. The neutralizer used consists of Saponin 3.0%, Polysorbate 80 3.0%, Lecithin 0.3%, Sodium Thiosulfate 0.5%, L-Histidine 0.1% (percentages expressed as w / v), supplemented with distilled water. It is sterilized at 121°C for 15 min. The strains tested are Staphylococcus aureus (DMS 799) and Escherichia Coli (DMS 682). The formulations are tested pure (100%) and diluted to 1% (ineffective concentration) and 80% in distilled water (percentages expressed as V / V). The tests are carried out at 30 ± 1°C. The contact time is 1 min ± 5 seconds for pre-milking products and 5 min ± 10 seconds for post-milking products. The tests are carried out in the presence of an interfering substance: 3 g / L of bovine albumin for the products before milking, which corresponds to low level dirt conditions (sterilization by filtration on a membrane of 0.45 pm porosity) and 10 g / L of skimmed milk powder for the products after milking (sterilization at 121°C for 5 min). The test surfaces are 4 cm² (2 cm x 2 cm) Vitro Skin synthetic skins. They are aseptically cut and then placed at room temperature in a rehydration chamber containing 300 mL of a 15% glycerin solution for a maximum of 16 to 24 hours. 50 µL of a [strain + interfering substance] mixture is applied to the skin, which is then placed in an incubator at 30 ± 1°C for 15 min. Next, the skin is immersed in 10 mL of the solution to be tested for 30 seconds, then drained, and placed in an incubator at 30 ± 1°C (test temperature) for the defined contact time minus 30 seconds. It is then transferred to the neutralizer, and then deposited on tryptone-soy agar (TSA). The incubation of the strains is carried out at 37 ± 1°C over two cycles of between 20 and 24 hours. The counting technique is a depth count (colony counting). The product subjected to a test carried out under pre-milking conditions must show a reduction of at least 3 decimal log. The product subjected to a test carried out under post-milking conditions must show a reduction of at least 4 decimal log.

[0052] EN 13697 + A1 (July 2019): Quantitative non-porous surface test for the evaluation of bactericidal and / or fungicidal activity of chemical disinfectants used in the food industry, in industry, in domestic and institutional settings. The test method is without mechanical action and requirements (phase 2, step 2). The test method consists of a dilution-neutralization. This method allows the biocidal action of the product to be stopped by the neutralizer at the end of the tested contact time. The neutralizer used consists of Saponin 3.0%, Polysorbate 80 3.0%, Lecithin 0.3%, Sodium Thiosulfate 0.5%, L-Histidine 0.1% (percentages expressed as w / v), supplemented with distilled water. It is sterilized at 121°C for 15 min. The strain tested is Candida albicans (DMS 1386). The incubation temperature of the strain is 30 ± 1°C for a period of 48 hours. The tests are carried out at 20 ± 1°C. The contact times are 5 min ± 10 seconds and 10 min ± 10 seconds. The tests are carried out in the presence of an interfering substance: 0.3 g / L of bovine albumin, which corresponds to clean conditions (sterilization by filtration on a membrane with a porosity of 0.45 pm). The test surfaces are 304 stainless steel discs (2 cm in diameter) with both sides having a grade 2b finish (cleaned in a 5% DECON solution for 60 minutes, rinsed with distilled water for 10 seconds, then sterilized in a bath containing 70% (V) isopropanol for 15 minutes and then dried under a laminar airflow). 50 pL of a mixture [strain + interfering substance] are deposited on the disc which is then placed in an incubator at 37 ± 1°C until visible drying which should not exceed 1 hour. 100 lp of the product under test are applied so as to cover the dried film. The surface is maintained at 20°C for the defined contact times. The surface is transferred into the neutralization medium so as to immediately neutralize the disinfectant. The number of surviving organisms that can be recovered from the surface is determined quantitatively. The detachment of microorganisms from the disc is achieved by contact and friction of the surface with glass beads of 3 mm in diameter. The number of yeasts present on a surface treated with hard water instead of being treated with the disinfectant is also determined, and the reduction in the number of viable cells attributed to the product is calculated by difference. In the case of bactericidality, the submitted product must show a reduction of at least 4 decimal log under the test conditions. In the case of yeasticidality, the submitted product must show a reduction of at least 3 decimal log under the test conditions.

[0053] Example 1: Disinfectant composition for udder hygiene according to the invention intended for use after milking

[0054] Composition of example 1 (% by weight): 2% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 6% of 1,2-hexanediol 8% glycerin 1% castor oil 33 OE 0.001% of a "ready-to-use" colorant mixture comprising 90% E102 (tartrazine yellow) and 10% E131 (patent blue V) 0.008% of an El02 dye (tartrazine yellow) 0.08% 50% NaOH to adjust the pH to 3.5 QSP water Classification of the composition of Example 1:

[0055] Specific concentration limits of propionic acid: If [active ingredient] = 100%: H314 (causes skin burns and eye damage) - H318 (causes serious eye damage) - H335 (may cause respiratory irritation) - H226 (highly flammable liquid and vapor). If 25% < [ma] < 100%: H314 (causes skin burns and eye damage) - H318 (causes serious eye damage) —> Specific concentration limit for calculating H314 and H318 = 25. If 10% < [ma] < 25% => H315 (causes skin irritation) - H319 (causes serious eye irritation) —> Specific concentration limit for calculating H315 and H319 = 10. If [ma] > 10% => H335 (may irritate the respiratory tract). Specific concentration limits for sodium hydroxide solution: If [ma] = 100%: H314 (causes skin burns and eye damage) -H290 (may be corrosive to metals). If 2% < [ma] < 100%: H314 (causes skin burns and eye damage) and H318 (causes serious eye damage) —> Specific concentration limit for calculating H314 and H318 = 2 If 0.5% < [ma] < 2%: H315 (causes skin irritation) and H319 (causes serious eye irritation) —> Specific concentration limit for calculating H315 and H319 = 0.5. Eye calculation: H318: only propionic acid and caustic soda should be taken into account 2 / 25 + 0.04 / 2 = 0.1 < 1 —> the mixture is not classified as H318. H319: Only propionic acid, sodium hydroxide, and 1,2-hexanediol should be taken into account 2 / 10 + 0.04 / 0.5 + 6 / 10 = 0.88 < 1 —> the mixture is not classified as H319 skin calculus: H314: Only propionic acid and sodium hydroxide solution should be considered. 2 / 25 + 0.04 / 2 = 0.1 < 1 —> the mixture is not classified as H314 H315: only propionic acid and caustic soda should be taken into account 2 / 10 + 0.04 / 0.5 = 0.28 < 1 —> the mixture is not classified H315 The product is not classified. Disinfectant efficacy: Phase 2. Step 1: EN 1656: 5 min, 30°C, 10 g / L skimmed milk on the limiting bacterium Staphylococcus aureus: 80% effective EN 1657: 5 min, 30°C, 10 g / L skimmed milk on Candida albicans: 100% effective. Phase 2, step 2: EN 17422: 5 min, 30°C, 10 g / L skimmed milk on the limiting bacterium Staphylococcus aureus: 100% effective These results show that the composition of example 1 is effective, that it does not contain substances of concern to humans and the environment, nor nanomaterials. The composition is therefore eligible for AMMS.

[0056] The composition of Example 1 was then tested in udder hygiene: the composition was sprayed using a conventional manual sprayer (supplier: CNTT) of IL onto the teats of an animal. No unpleasant odor was detected during milking.

[0057] Example 2: Disinfectant composition for udder hygiene according to the invention intended for use after milking

[0058] Composition of example 2 (% by weight): 2% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 4% of 1,2-hexanediol 8% glycerin 1% sodium n-octyl sulfate 0.001% of a "ready-to-use" colorant mixture comprising 90% E102 (tartrazine yellow) and 10% E131 (patent blue V) 0.008% of an El02 dye (tartrazine yellow) 0.02% HCl at 33% to adjust the pH to 2.8 qs water Classification of the composition of Example 2:

[0060] Specific concentration limits of propionic acid:

[0061] See example 1

[0062] Specific concentration limits of sodium n-octyl sulfate: If [ma] > 20%: H318 (causes serious eye damage) —> Specific concentration limit for calculating H318 = 20. If 10% < [ma] < 20%: H319 (causes serious eye irritation) —> Specific concentration limit for calculating H319 = 10. Specific concentration limits of hydrochloric acid: If [ma] = 100%: H314 (causes skin burns and eye damage), H318 (causes serious eye damage), H335 (may cause respiratory irritation), H290 (may be corrosive to metals). If 25% < [ma] < 100%: H314 (causes skin burns and eye damage), H318 (causes serious eye damage), H335 (may cause respiratory irritation) —> Specific concentration limit for calculating H314 and H318 = 25.

[0063] If 10% < [ma] < 25%: H315 (causes skin irritation), H319 (causes serious eye irritation), H335 (may cause respiratory irritation) —> Specific concentration limit for calculating H315 and H319 = 10. Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate and hydrochloric acid should be taken into account 2 / 25 + 1 / 20 + 0.007 / 25 = 0.13 < 1 —> the mixture is not classified as H318 H319: Only propionic acid, sodium n-octyl sulfate, hydrochloric acid, and 1,2-hexanediol should be taken into account 2 / 10 + 1 / 10 + 0.007 / 10 + 4 / 10 = 0.7 < 1 —> the mixture is not classified as H319 skin calculus: H314: Only propionic acid and hydrochloric acid should be considered. 2 / 25 + 0.007 / 25 = 0.08 < 1 —> the mixture is not classified as H314 H315: Only propionic acid, sodium n-octyl sulfate and hydrochloric acid should be taken into account 2 / 10 + 1 / 10 + 0.007 / 10 = 0.3 < 1 —> the mixture is not classified as H315 The product is not classified. Disinfectant efficacy: Phase 2. Step 1: EN 1656: 5 min, 30°C, 10 g / L skimmed milk on Staphylococcus aureus, E. Coli, Strep-tococcus uberis: 50% effective EN 1657: 5 min, 30°C, 10 g / L skimmed milk on Candida albicans: 100% effective. Phase 2, step 2: EN 17422: 5 min, 30°C, 10 g / L skimmed milk on Staphylococcus aureus, E. Coli: 100% effective These results show that the composition of example 2 is effective, that it does not It contains no substances of concern to humans and the environment, nor nanomaterials. The composition is therefore eligible for AMMS.

[0064] The composition of Example 2 was then tested in udder hygiene: the composition was sprayed using a conventional manual sprayer (supplier: CNTT) of IL onto the teats of an animal. No unpleasant odor was detected during milking. A light foam formed upon application, which helps the product adhere to the teats and allows for good visibility of the applied product. Good distribution of the product on the teats was observed.

[0065] Example 3: Disinfectant composition for udder hygiene according to the invention intended for use before milking

[0066] Composition of example 3 (% by weight): 2% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 6% of 1,2-hexanediol 8% glycerin 5% xylitol 1% sodium n-octyl sulfate 0.8% sodium lauryl glucoside hydroxypropyl sulfonate 0.009% of the colorant E104 (quinoline yellow) 0.0001% of the colorant E133 (brilliant blue) 0.12% HCl at 33% to adjust the pH to 2.3 QSP water Classification of the composition of Example 3: Specific concentration limits of propionic acid:

[0068] See example 1

[0069] Specific concentration limits of sodium n-octvl sulfate and hydrochloric acid:

[0070] See example 2

[0071] Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate and hydrochloric acid should be taken into account. 2 / 25 + 1 / 20 + 0.04 / 25 = 0.14 < 1 —> the mixture is not classified as H318 H319: Only propionic acid, sodium n-octyl sulfate, hydrochloric acid and 1,2-hexanediol should be taken into account 2 / 10 + 1 / 10 + 0.04 / 10 + 6 / 10 = 0.9 < 1 —> the mixture is not classified as H319 Skin calculation: H314: Only propionic acid and hydrochloric acid should be taken into account. 2 / 25 + 0.04 / 25 = 0.08 < 1 —> the mixture is not classified as H314 H315: Only propionic acid, hydrochloric acid, and sodium n-octyl sulfate should be taken into account 2 / 10 + 0.04 / 10 + 1 / 10 = 0.3 < 1 —> the mixture is not classified H315 The product is not classified. Disinfectant efficacy: Phase 2. Step 1: EN 1656: 1 min, 30°C, 3 g / L of bovine albumin on the limiting bacterium Staphylococcus aureus: 80% effective EN 1657: 1 min, 30°C, 3 g / L of bovine albumin on Candida albicans: 100% effective Phase 2, step 2: EN 17422: 1 min, 30°C, 3 g / L of bovine albumin on the limiting bacterium Staphylococcus aureus: 100% efficacy These results show that the composition of example 3 is effective, that it does not contain substances of concern to humans and the environment, nor nanomaterials. The composition is therefore eligible for AMMS.

[0072] The composition of Example 3 was then tested in udder hygiene: the composition was sprayed using a conventional manual sprayer (supplier: CNTT) of IL onto the teats of an animal. No unpleasant odor was detected during milking. A light foam formed upon application, which helps the product adhere to the teats and allows for good visibility of the applied product. Good distribution of the product on the teats and good cleaning were observed.

[0073] Example 4: Disinfectant composition for udder hygiene according to the invention intended for use after milking

[0074] Composition of example 4 (% by weight): 1% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 7% of 1,2-hexanediol 1% sodium 2-ethylhexyl iminodipropionate 0.77% HCl at 33% to adjust the pH to 2.3 qs water Classification of the composition of Example 4: Specific concentration limits of propionic acid:

[0076] See example 1

[0077] Specific concentration limits of hydrochloric acid:

[0078] See example 2

[0079] Eye calculation: H318: Only propionic acid and hydrochloric acid should be taken into account. 1 / 25 + 0.25 / 25 = 0.05 < 1 —> the mixture is not classified as H318 H319: Only propionic acid, hydrochloric acid and 1,2-hexanediol should be taken into account 1 / 10 + 0.25 / 10 + 7 / 10 = 0.83 < 1 —> the mixture is not classified as H319 skin calculus: H314: Only propionic acid and hydrochloric acid should be taken into account. 1 / 25 + 0.25 / 25 = 0.05 < 1 —> the mixture is not classified as H314 H315: only propionic acid and hydrochloric acid should be taken into account 1 / 10 + 0.25 / 10 = 0.13 < 1 —> the mixture is not classified H315 The product is not classified. Disinfectant efficacy: Phase 2. Step 1: EN 1656: 5 min, 30°C, 10 g / L skimmed milk on the limiting bacterium Staphylococcus aureus: 80% effective EN 1657: 5 min, 30°C, 10 g / L skimmed milk on Candida albicans: 100% effective. Phase 2, step 2: EN 17422: 5 min, 30°C, 10 g / L skimmed milk on the limiting bacterium Staphylococcus aureus: 100% effective

[0080] These results show that the composition of Example 4 is effective, that it does not contain substances of concern to humans and the environment, nor nanomaterials. The composition is therefore eligible for AMMS.

[0081] Example 5: Disinfectant composition for udder hygiene according to the invention

[0082] Composition of example 5 (% by weight): 2% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 6% of 1,2-hexanediol 8% glycerin 5% xylitol 1% sodium n-octyl sulfate 0.8% sodium lauryl glucosides hydroxypropyl sulfonate 0.12% HCl at 33% to adjust the pH to 2.3 QSP water

[0083] Disinfectant efficacy: Phase 2. Step 1: EN 1657: 1 min, 30°C, 3 g / L of bovine albumin on Candida albicans: 100% effective (reduction > 4.39 log for 4 log required).

[0084] Comparative example 1: Disinfectant composition compared to example 1 based on lactic acid

[0085] A composition comparable to the composition of Example 1 was prepared, in which propionic acid was replaced by lactic acid Composition of comparative example 1 (% by weight): 2% lactic acid 6% of 1,2-hexanediol 8% glycerin 1% castor oil 33 OE 0.001% of a "ready-to-use" colorant mixture comprising 90% E102 (tartrazine yellow) and 10% E131 (patent blue V) 0.008% of an El02 dye (tartrazine yellow) 0.28% sodium hydroxide solution to adjust the pH to 3.5 QSP water Classification of the composition of comparative example 1:

[0086] Eye calculation: H318: Only lactic acid and caustic soda should be taken into account 2 / 3 + 0.28 / 2 = 0.81 < 1 —> the mixture is not classified as H318. H319: Only lactic acid, sodium hydroxide, and 1,2-hexanediol should be taken into account 2 / 1 + 0.28 / 0.5 + 6 / 10 = 3.16 > 1 —> the mixture is classified as H319 skin calculus: H314: Only lactic acid and caustic soda should be taken into account 2 / 5 + 0.28 / 2 = 0.54 < 1 —> the mixture is not classified as H314 H315: Only lactic acid and caustic soda should be taken into account 2 / 1 + 0.28 / 0.5 = 2.56 > 1 —> the mixture is classified as H315 The product is therefore classified and does not meet objective (iii) referred to above (lack of classification according to the criteria of European Regulation No. 1272 / 2008).

[0087] Comparative Example 2: Disinfectant composition compared to Example 2 based on lactic acid

[0088] A composition comparable to the composition of Example 2 was prepared, in which propionic acid was replaced by lactic acid Composition of comparative example 2 (% by weight): 2% lactic acid 4% of 1,2-hexanediol 8% glycerin 1% sodium n-octyl sulfate 0.001% of a "ready-to-use" colorant mixture comprising 90% E102 (tartrazine yellow) and 10% E131 (patent blue V) 0.008% of an El02 dye (tartrazine yellow) 0.08% sodium hydroxide solution to adjust the pH to 2.8 QSP water

[0089] Classification of the composition of comparative example 2:

[0090] Eye calculation: H318: Only lactic acid, sodium n-octyl sulfate, and caustic soda should be taken into account 2 / 3 + 1 / 20 + 0.08 / 2 = 0.76 < 1 —> the mixture is not classified as H318 H319: Only lactic acid, sodium n-octyl sulfate, caustic soda, and 1,2-hexanediol should be taken into account 2 / 1 + 1 / 10 + 0.08 / 0.5 + 4 / 10 = 2.66 > 1 —> the mixture is classified as H319 skin calculus: H314: Only lactic acid and caustic soda should be taken into account 2 / 5 + 0.08 / 2 = 0.44 < 1 —> the mixture is not classified as H314 H315: Only lactic acid, sodium n-octyl sulfate, and caustic soda should be taken into account 2 / 1 + 1 / 10 + 0.08 / 0.5 = 2.26 > 1 —> the mixture is classified as H315 The product is therefore classified and does not meet objective (iii) referred to above (lack of classification according to the criteria of European Regulation No. 1272 / 2008).

[0091] Comparative example 3: Disinfectant composition compared to example 3 based on lactic acid

[0092] A composition comparable to the composition of Example 3 was prepared, in which propionic acid was replaced by lactic acid Composition of comparative example 3 (% by weight): 2% lactic acid 6% of 1,2-hexanediol 8% glycerin 5% xylitol 1% sodium n-octyl sulfate 0.8% sodium lauryl glucoside hydroxypropyl sulfonate 0.009% of the colorant E104 (quinoline yellow) 0.0001% of the colorant E133 (brilliant blue) 0.04% HCl at 33% to adjust the pH to 2.3 QSP water

[0093] Classification of the composition of comparative example 3: Eye calculation: H318: Only lactic acid, sodium n-octyl sulfate, and hydrochloric acid should be taken into account 2 / 3 + 1 / 20 + 0.013 / 25 = 0.72 < 1 —> the mixture is not classified as H318 H319: Only lactic acid, sodium n-octyl sulfate, hydrochloric acid and 1,2-hexanediol should be taken into account 2 / 1 + 1 / 10 + 0.013 / 10 + 6 / 10 = 2.7 > 1 —> the mixture is classified as H319 skin calculus: H314: Only lactic acid and hydrochloric acid should be taken into account. 2 / 5 + 0.013 / 25 = 0.40 < 1 —> the mixture is not classified as H314 H315: Only lactic acid, hydrochloric acid, and sodium n-octyl sulfate should be taken into account 2 / 1 + 0.013 / 10 + 1 / 10 = 2.1 > 1 —> the mixture is classified as H315 The product is therefore classified and does not meet objective (iii) mentioned above (lack of classification according to the criteria of European Regulation No. 1272 / 2008). Comparative example 4: Disinfectant composition compared to example 4 based on lactic acid

[0094] Composition of comparative example 4 (% by weight): 1% lactic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 7% of 1,2-hexanediol 1% sodium 2-ethylhexyl iminodipropionate 0.68% HCl at 33% to adjust the pH to 2.3 QSP water

[0095] Classification of the composition of Example 4: Eye calculation: H318: Only lactic acid and hydrochloric acid should be taken into account. 1 / 3 + 0.22 / 25 = 0.34 < 1 —> the mixture is not classified as H318 H319: Only lactic acid, hydrochloric acid and 1,2-hexanediol should be taken into account 1 / 1 + 0.22 / 10 + 7 / 10 = 1.72 > 1 —> the mixture is classified as H319 skin calculus: H314: Only lactic acid and hydrochloric acid should be considered. 1 / 5 + 0.22 / 25 = 0.21 < 1 —> the mixture is not classified as H314 H315: Only lactic acid and hydrochloric acid should be considered. 1 / 1 + 0.22 / 10 = 1.022 > 1 —> the mixture is classified as H315 The product is therefore classified and does not meet objective (iii) referred to above (absence of classification according to the criteria of European Regulation No. 1272 / 2008). Comparative Example 5: Disinfectant composition compared to example 5

[0096] Composition of comparative example 5 (% by weight): 2% propionic acid (active substance listed in Annex I of European Regulation (EU) No 528 / 2012) 0% of 1,2-hexanediol 8% glycerin 5% xylitol 1% sodium n-octyl sulfate 0.8% sodium lauryl glucosides hydroxypropyl sulfonate 0.11% of 33% HCl to adjust the pH to 2.3 QSP water

[0097] Disinfectant efficacy: Phase 2. Step 1: EN 1657: 1 min, 30°C, 3 g / L of bovine albumin on Candida albicans: not effective (reduction < 3.02 log for 4 log required).

[0098] The product does not meet the objective (iv) referred to above; it does not achieve the disinfectant efficacy set out in the Biocidal Products Regulation and the Practical Guide to the Biocidal Products Regulation - ECHA, Volume II Efficacy - Evaluation and Assessment (Parts B + C).

[0099] Example 6 according to the invention and comparison: Following the same protocol as the previous examples, two compositions based on propionic acid and 1,2-hexanediol were compared to two similar compositions in which the 1,2-hexanediol was replaced by citric acid. The formulations and results are summarized in Table 1 below (the percentages shown are weight percentages): [Tables 1] Formulations Composition 6a according to the invention Composition 6b according to the invention Comparative composition 6a Comparative composition 6b Demineralized water 82.944% 82.976% 82.528% 82.744% Propionic acid 2.000% 5.000% 2.000% 5.000% Glycerin 8.000% 8.000% 8.000% 8.000% Citric acid - - 7.000% 4.000% 1,2 Hexanediol 7.000% 4.000% - - Adjustment of pH to 2.3 with 50% sodium hydroxide solution - - 0.472% 0.256% Adjustment of pH to 2.3 with 33% hydrochloric acid 0.056% 0.024% - - EN 1657 Standard Candida albicans 5 min, 30°C, 3 g / L bovine albumin (required reduction: 4 logs) 100% effective R > 4.41 log Not 100% effective R < 3.04 log Not 100% effective R < 3.04 log EN 1657 Standard Candida albicans 1 min, 30°C, 3 g / L bovine albumin 100% effective R > 4.15 log 100% effective R > 4.49 log Compositions containing a mixture of propionic acid and 1,2-hexanediol showed efficacy within 1 minute. Compositions without 1,2-hexanediol showed no efficacy, even after 5 minutes.

[0100] Example 7: Disinfectant compositions according to the invention for use before treat

[0101] Following the same protocol as the previous examples, three compositions based on propionic acid and 1,2-hexanediol were prepared and tested before milking. The formulations and results are summarized in Table 2 below (the percentages shown are weight percentages): [Tables2] Formulations Composition 7a Composition 7b Composition 7c Demineralized water 75.92% 77.44% 75.99 Propionic acid 2.0% 2.0% 2.0% 1,2 Hexanediol 6.5% 7.5% 7.5% Glycerin 8.0% 8.0% 8.0% Xylitol 5.0% 5.0% 5.0% 2-Ethylhexyl sulfate sodium 1.0% - - 2-Ethylhexyl iminodipropionate 0.8% - 0.8% pH adjustment to 2.3 with 33% hydrochloric acid 0.78% 0.06% 0.71% Standard EN 1657 Candida albicans 30 seconds, 30°C, 3 g / L bovine albumin (reduction (Required: 4 logs) 100% effective R = 4.14 log 100% effective R > 4.39 log Not 100% effective R > 4.39 log The three compositions 7a, 7b and 7c showed effectiveness in the forward milking process within 30 seconds.

[0102] Example 8: Disinfectant composition according to the invention for surface disinfection

[0103] Composition of example 8 (% by weight): 2% propionic acid 0.5% of 1,2-hexanediol 1% sodium n-octyl sulfate 0.08% HCl at 33% to adjust the pH to 2.3 QSP water

[0104] Classification of the composition of Example 8: Specific concentration limits of propionic acid:

[0105] See example 1

[0106] Specific concentration limits of sodium n-octvl sulfate and acid hydrochloric acid:

[0107] See example 2

[0108] Eye calculation: H318: Only propionic acid, sodium n-octyl sulfate and hydrochloric acid should be taken into account 2 / 25 + 1 / 20 + 0.003 / 25 = 0.13 < 1 —> the mixture is not classified as H318 H319: Propionic acid, sodium n-octyl sulfate, hydrochloric acid and 1,2-hexanediol must be taken into account 2 / 10 + 1 / 10 + 0.08 / 10 + 0.5 / 10 = 0.36 < 1 —> the mixture is not classified as H319 skin calculus: H314: Only propionic acid and hydrochloric acid should be considered. 2 / 25 + 0.08 / 25 = 0.08 < 1 —> the mixture is not classified as H314

[0109] H315: only propionic acid, sodium n-octyl sulfate and chlorinated acid water resources must be taken into account 2 / 10 + 1 / 10 + 0.08 / 10 = 0.31 < 1 —> the mixture is not classified as H315 The product is not classified. Disinfectant efficacy: Phase 2, step 2: EN 13697 (most limiting test): 10 min, 30°C, 0.3 g / L bovine albumin on Candida albicans: 100% effective These results show that the composition of example 5 is effective, that it does not contain substances of concern to humans and the environment, nor nanomaterials. The composition is therefore eligible for AMMS.

[0110] Example 9: Evaluation of different diols

[0111] Various diols were evaluated in the following basic formula 1 (the % indicated are % by weight): [Tables3] Basic Formula 1: Demineralized Water 79.80%, Propionic Acid 5.00%, Glycerin Codex 8.00%, Diol 8.00%, Sodium Alkylamine Carboxylate 2.50%, 33% HCl to adjust pH to 2.3 (0.7%) The results obtained are summarized in Table 4 below: [Tables4] Diols tested: 1,6-hexanedio, 2,3-butanedio, Isopentyldiol, 1,3-propanedio (not part of this invention). EN 1656, 5 min, 30°C, 10 g / L skimmed milk. Staphylococcus aureus, 80% (reduction required R > 5). Effective R > 5.38 log. Effective R = 5.46 log. Effective R > 5.49 log. Not effective R < 4.12 log. Two other diols were compared on the following base 2 formula (the % indicated are % by weight): [Tables5] Basic Formula 2: Demineralized Water 82.93%, Propionic Acid 2.00%, Glycerin Codex 8.00%, Diol 6.00%, Castor Oil 33OE 1.00%, 50% Sodium Lye to adjust pH to 2.3 0.07% The results obtained are summarized in Table 6 below: [Tables] Diols tested: 1,2-hexanedio-1, 1,3-propanediol (not part of this invention) EN 1657, 5 min, 30°C, 10 g / L skimmed milk, Candida albicans, 100% Effective R > 4.37 log Not effective R < 3.00 log

Claims

Demands

1. Disinfectant composition characterized in that it comprises: A) from 0.1 to less than 10% by weight of propionic acid, relative to the total weight of the disinfectant composition, B) at least one linear or branched aliphatic or cycloaliphatic diol having 4 to 8 carbon atoms, selected from 1,2-hexanediol, 2-methyl-1,3-propanediol, meso-2,3-butanediol, isopentyldiol, 1,6-hexanediol, 1,2-pentanediol, 1,4-cyclohexanedimethanol, and mixtures thereof, C) at least one surfactant selected from anionic, non-ionic, amphoteric, glycolipidic surfactants, and mixtures thereof, and D) water, said disinfectant composition having a pH greater than 2.0 and less than 4.

87.

2. Disinfectant composition according to claim 1, characterized in that propionic acid A) represents from 0.1 to 5%, and preferably from 1 to 5%, by weight relative to the total weight of the disinfectant composition.

3. Disinfectant composition according to claim 1 or claim 2, characterized in that diol B) is selected from 1,2-hexanediol, 1,6-hexanediol, and mixtures thereof.

4. Disinfectant composition according to any one of claims 1 to 3, characterized in that diol B) is a linear or branched aliphatic or cycloaliphatic vicinal diol having 4 to 6 carbon atoms, and preferably 1,2-hexanediol.

5. Disinfectant composition according to any one of claims 1 to 4, characterized in that diol B) represents from 0.1 to less than 10%, and preferably from 1 to 8%, by weight relative to the total weight of the disinfectant composition.

6. Disinfectant composition according to any one of claims 1 to 5, characterized in that the surfactant C) is selected from anionic, non-ionic surfactants, and mixtures thereof.

7. Disinfectant composition according to claim 6, characterized in that the surfactant C) is an anionic surfactant selected from alkyl sulfonate salts, olefin sulfonate salts, paraffin sulfonate salts, glucoside sulfonate salts, alkyl sulfate salts, alkyl ether sulfate salts, alkyl taurate salts, salts of acyl glutamate, alkyl ether carboxylic acids and their salts, and mixtures thereof, preferably selected from sodium lauryl glucoside hydroxypropyl sulfonate, sodium decyl glucoside hydroxypropyl sulfonate, sodium 2-ethylhexyl sulfate, sodium n-octyl sulfate, sodium lauryl sulfate, sodium laureth sulfate, sodium methyl cocoyl taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium capryloyl glutamate, capryleth-9 carboxylic acid, optionally in mixture with buteth-2 carboxylic acid, laureth-11 carboxylic acid, and mixtures thereof, and more preferably sodium n-octyl sulfate, sodium lauryl glucoside hydroxypropyl sulfonate, sodium 2-ethylhexyl sulfate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium capryloyl glutamate, and mixtures thereof.

8. Disinfectant composition according to claim 6, characterized in that the surfactant C) is a nonionic surfactant selected from sorbitan esters, glycerol esters, polyglycerol esters, alkyl polyglucosides, alkyl polypentosides, alkanoyl lactyl lactate, ethoxylated alcohols, ethoxylated castor oils, and mixtures thereof, preferably sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioctanoate, glyceryl caprylate / caprate, polyglyceryl-3 caprylate, polyglyceryl-4 caprate, C10-C16 alkyl polyglucosides, C5 and C10-C12 amyl xylosides, lauryl lactyl lactate, C10 ethoxylated alcohols, castor oils ethoxylated, and their mixtures, and more preferably sorbitan monooleate, polyglyceryl-4 caprate, alkyl polyglucosides in Ci0-Ci6, ethoxylated castor oils, and their mixtures.

9. Disinfectant composition according to any one of claims 1 to 8, characterized in that the surfactant C) represents from 0.1 to less than 10%, and preferably from 0.1 to 5%, by weight relative to the total weight of the disinfectant composition.

10. A disinfectant composition according to any one of claims 1 to 9, characterized in that said composition further comprises at least one moisturizing agent E), preferably selected from polyols other than diol B), hyaluronic acid and its derivatives, alginates, urea, and mixtures thereof, more preferably from polyols other than diol B) such as those selected from glycerin, propylene glycol, sorbitol, xylitol, erythritol, mannitol, xylose, and mixtures thereof, and even more preferably glycerin, propylene glycol, and their blend.

11. Disinfectant composition according to claim 10, characterized in that the moisturizing agent E) represents from 0 to 30%, and preferably from 1 to 20%, by weight relative to the total weight of the disinfectant composition.

12. Disinfectant composition according to any one of claims 1 to 11, characterized in that said composition further comprises at least one pH regulating agent F) the nature and quantity of which are chosen such that said composition has a pH greater than 2.0 and less than 4.87, said pH regulating agent being chosen from acids such as hydrochloric acid and sulfuric acid, or bases such as sodium hydroxide and potassium hydroxide.

13. Disinfectant composition according to claim 12, characterized in that the pH regulating agent (F) represents 0 to 1%, preferably 0.01 to 0.5%, and more preferably 0.01 to 0.25%, by weight relative to the total weight of the disinfectant composition.

14. Disinfectant composition according to any one of claims 1 to 13, characterized in that the pH of said composition is greater than 2.1 and less than 4.0, and preferably greater than 2.3 and less than 3.

5.

15. Disinfectant composition according to any one of claims 1 to 14, characterized in that said composition further comprises one or more excipients selected from colorants, opacifying agents, thickening agents.

16. Disinfectant composition according to any one of claims 1 to 15, characterized in that said composition is in liquid, gel or foam form, and can be applied by soaking or spraying.

17. Use of a composition according to any one of claims 1 to 16, for the disinfection of the udders and teats of an animal, before or after milking.

18. Use of a composition according to any one of claims 1 to 16, for the disinfection of surfaces, and preferably for the disinfection of open surfaces.

19. A method for disinfecting the udders and teats of an animal before or after milking, comprising the steps of: (i) applying a composition according to any one of claims 1 to 16 to the udders and teats of the animal, before and / or after milking the animal, then (ii) Optionally, removal of said composition from the udders and teats of the animal, preferably by wiping.

20. A method according to claim 19 for disinfecting the udders and teats of an animal, wherein the contact time of the disinfectant composition on the udders and teats of the animal during step (i), before milking the animal, varies from 30 seconds to 3 minutes, and preferably from 30 seconds to 1 minute and 30 seconds.

21. A method according to claim 19 for disinfecting the udders and teats of an animal, wherein the contact time of the disinfectant composition on the udders and teats of the animal during step (i), after milking the animal, is less than 5 minutes, and preferably less than 30 seconds.

22. A method for disinfecting a surface, characterized in that it comprises a step of applying a composition according to one of claims 1 to 16 to the surface to be disinfected, and preferably to an open surface, said application step being optionally followed by a rinsing and / or drying step.