REGULATED EXPRESSION IN THE TUMOR MICROENVIRONMENT

Abstract

The present invention relates generally to the field of medicine. More particularly, it relates to an animal eukaryotic cell for use in the treatment of a solid tumor in a patient in need of it, said cell comprising a novel expression cassette allowing the controlled expression of a first therapeutic transgene within and by said solid tumor. (Figure 1)

Claims

6. An animal eukaryotic cell according to claim 5, wherein said at least a first therapeutic transgene is a chimeric antigen receptor (CAR), in particular a CAR selected from: an anti-A-folate receptor CAR, an anti-Carbonic anhydrase IX CAR, an anti-CD 171 CAR, an anti-CD19 CAR, an anti-CD20 CAR, an anti-CD276 CAR, an anti-319 CAR, an anti-CEA CAR, an anti-cMet CAR, an anti-EGFR CAR, an anti-EGFRIII CAR, an anti-EGFRn CAR, an anti-FAP CAR, an anti-GD2 CAR, an anti-gplOO CAR, an anti-GPC3 CAR, an anti-HER2 CAR, an anti-IL13Ra2 CAR, an anti-MAGE CAR, an anti-MART-1 CAR, an anti-MSLN CAR, an anti-Mute 1 CAR, an anti-Mute 16 CAR, a CAR anti-NKG2D, an anti-PSMA CAR, an anti-TRP-1 CAR, an anti-TRP2 CAR, an anti-VEGFR CAR, an anti-HLA-G CAR, an anti-CLDN18.2 CAR, an anti-EPCAM CAR, an anti-FAP CAR, an anti-RORl CAR, an anti-ROR2 CAR, an anti-PD1 CAR and an anti-PSCA CAR.

7. Animal eukaryotic cell according to claim 5 or 6, wherein said expression cassette further comprises a second transgene downstream of said first transgene, said second transgene being in particular: • a transcription factor, in particular a transcription factor selected from: c-JUN, F0X01, B ATF, TB ET and NRF2; • a cytokine, in particular a cytokine selected from: IL2, IFNy, TNFa, IL18, and IL12; or • a transporter, in particular the GLUT1 transporter.

8. Animal eukaryotic cell according to claim 7, wherein said second transgene is c-JUN, the nucleic acid of which has a sequence having at least 90% identity with the nucleic acid of sequence SEQ ID NO: 9 or the nucleic acid of which codes an amino acid sequence having at least 90% identity with the sequence SEQ ID NO:

10. 3) | 2xAARE | ¥8 TATA j CAR ) p2a | JUN [Fig. 7] A)ws [Fig. 8] Carence glucose ; Carence glucose $ § ----------------------------T----------------------------v----------------------------r § 4..............—?----------------------------?----------------------------r 3 24 4« o 24 72 [Fig. 9] [Fig. 11] 2x~GFP -f- ULBP1 HSPAIb ■* Chacl -♦- WT Intensité GFP 10- AA A M****^ÀÀ^ X ' Z À X x X f A X À X y X X y*T w-Tr wM J» 0 12 24 36 48 60 72 84 96 hours Nucleotide sequence Sequence Listing 1 Sequence Listing Information File Name FR2412563.xml 1-2 DTD Version V1 3 ■11111 1-4 Software Version 2.3.0 lilillllll Production Date 1-6 Original free text lanquaqe code Non Enqlish free text lanquaqe code 2 General Information Current application: IP Office 2-2 Current application: Application number 2-3 Current application: Filinq date 2-4 Current application: Applicant file reference IFB24AMASFENZO 2-5 Earliest priority application: IP Office 2-6 Earliest priority application: Application number 2-7 Earliest priority application: Filing 2-8fr Applicant name ASFALIA BIOLOGICS 2-8 Applicant name: Name Latin 2-9 Inventor name lilM Inventer name: Name Latin 2-10fr Invention title EXPRESSION REGULEE DANS LE MICROENVIRONNEMENT TUMORAL iiiii® Sequence Total Quantity iiiiiiiiiM 3-1 Sequences liiiii 3-1-2 Molécule Type DNA liiiii® iOiiiM 3-1-4-1 Features Location / Qualifiers source 1.282 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-1-5 Residues tttgcatcac ccggaccggg ggattagctc c ctccggtttg catcacccgg accgggggcc catcacccgg accgggggat tagctccggt ggtttgcatc acccggaccg gggactcgag ctactaccaq aaaqcttqqt accqaqctcq ç ggtttgcat cacccggacc gggggattag gggcgcgtgc tagegattag ctccggtttg tgcatcacc cggaccgggg gattagctcc ctagagggt atataatggg ggccactagt atccaqcca cc 3-2 Sequences 3-2-1 Sequence Number [ID] 2 3-2-2 Molécule Type. 3-2-3 Lenqth 249 3-2-4-1 Features Location / Qualifiers source 1..249 mol_type= other DNA organism» synthetic construct NonEnqlishQualifier Value 3-2-5 Residues tttgcatcac ccggaccggg ggattagctc cggtttgcat cacccggacc gggggattag ctccggtttg catcacccgg accgggggcc gggcgcgtgc tagcgattag ctccggtttg catcacccgg accgggggat tagctccggt ttgcatcacc cggaccgggg gattagctcc ggcctcgaa 3-3 Sequences iiii® Sequence Number 0D] 3-3-2 Molécule Type DNA 3-3-3 3-3-4-1 Features Location / Qualifiers source 1..243 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-3-5 Residues gttgcatcac tcactgatat tcccgttgca tcactcttga cctacccgtt gcatcactca aaggtcttcc cgggcgcctg acgcaatccg aggcgccctt gctgcatgcc cgggggattc atatcctccc gttgcatcac tctgttagac ccgttgcatc actcacctta gcccgttgca tcactccccg gaccggggat tcgagtctag agggtatata atgggggcca ctagtctact acc 3-4 Sequences 3-4-1 Sequence Number [ID] 4 3-4-2 Molécule Type DNA 3-4-3 Lenqth 1105 3-4-4-1 Features Location / Qualifiers source 1.,1105 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-4-3 Residues cttcactcca gcctgggcaa cagagtaaga ctcagtctca agaaaaaaaa aaaaaaagac gagccccatt cactûcûaûa aetgtctcat tcattcacÈg gttaactcag cctccaacca ctcagggcca tgaagaggcc atggcctgta cagccacgga tttgggtgtt gttagacaca tccatggaaa cacaactgat cacatcatga ttgatcacgg tagccctctg gaatggggaa gcggctgcgc cctggacgga gaggggcggg gacttcgcga ctgcaggcgg agggagggcg gtttcttcat cttcctgtgc attatttgat ggggccatgg aaggaacgga aggaacggcg tcctggcccg ctcggggccc gcgcacgccg ccaccaagcc gcgggggcgg gtcggagggg agagttgcgt cagccaggcc gctgtcagat gacgagcccg gggcgtgacg gggtggagca tccccaaaaa agtgcatgcc taggatcccg cccagtgtat ccctgcgcgc ggcgggccgg gctgggcagc tttataaaca gccgtggtgt gagcctcgaa gggaaccatc agcgcctcct qtccacqqaq ctccaqqtct acaat 3-5 Sequences 3-5-1 Sequence Number [ID] 3-5-2 Molécule Type DNA. 3-5-3 3-5-4-1 Features Location / Qualifiers source 1..11669 mol_type= other DNA organism= synthetic construct Non E nglishQualifier Value^ 3-5-5 Residues ccagatcctc tacgccggac gcatcgtggc cggcatcacc ggcgccacag gtgcggttgc tggcgcctat atcgccgaca tcaccgatgg ggaagatcgg gctcgccact tcgggctcat gagcgcttgt ttcggcgtgg gtatggtggc aggccccgtg gccgggggac tgttgggcgc catctccttg catgcaccat tccttgcggc ggcggtgctc aacggcctca acctactact gggctgcttc ctaatgcagg agtcgcataa gggagagcgt cgaatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccgtattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc attaccatga gtgataacac tggactagctgaccac gagctaaccg cttttgca siacatgggg gatcatgtaa ctcgccttga tcgttggaa ccggagctga atgagccat accaacgac gagcgtgaca caccacgatgcc tgtagcaatg gcacaacggat tgcagcaact atttaactggc gaggacgactactta ggataaagtt gcaggaccac ttctgcgctc ggccttccg gctggctggt ttattgctga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc aaggatacgtag ttatctac gaggcagacggagt taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgatt aaaacttcat ttttaattta aaaggatcta ggtgagatc cttttgata atctcatgac CAAatccct taacgtgagt ttcgcttcca agactgaccgagtag aactgaccgactca tttttctgcg cgtaatctgc tgcttgcaaa CAAaaaacc accgctacca gcggtggttt gttgccga tcagagcta ccaactcttt ttccgaggt aactggctcagcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactccgcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct aggcttttgc aaaaagcttg gacacaagac aggcttgcga gatatgtttg agaataccac tttatcccgc gtcagggaga ggcagtgcgt aaaaagacgc ggactcatgt gaaatactgg tttttagtgc gccagatctc tataatctcg cgcaacctat tttcccctcg aacacttttt aagccgtaga taaacaggct gggacacttc acatgagcga aaaatacatc gtcacctggg acatgttgca gatccatgca cgtaaactcg caagccgact gatgccttct gaacaatgga aaggcattat tgccgtaagc cgtggcggtc tgtaccgggt gcgttactgg cgcgtgaact gggtattcgt catgtcgata ccgtttgtat ttccagctac gatcacgaca accagcgcga gcttaaagtg ctgaaacgcg cagaaggcga tggcgaaggc ttcatcgtta ttgatgacct ggtggatacc ggtggtactg cggttgcgat tcgtgaaatg tatccaaaag cgcactttgt caccatcttc gcaaaaccgg ctggtcgtcc gctggttgat gactatgttg ttgatatccc gcaagatacc tggattgaac agccgtggga tatgggcgtc gtattcgtcc cgccaatctc cggtcgctaa tcttttcaac gcctggcact gccgggcgtt gttcttttta acttcaggcg ggttacaata gtttccagta agtattctgg aggctgcatc catgacacag gcaaacctga gcgaaaccctgttcaaaccc cgctttaaac atcctgaaac ctcgacgcta gtccgccgct ttaatcacgg cgcacaaccg cctgtgcagt cggcccttga tggtaaaacc atccctcact ggtatcgcat gattaaccgt ctgatgtgga tctggcgcgg cattgaccca cgcgaaatcc tcgacgtcca ggcacgtatt gtgatgagcg atgccgaacg taccgacgat gatttatacg atacggtgat tggctaccgt ggcggcaact ggatttatga gtgggccccg gatctttgtg aaggaacctt acttctgtgg tgtgacataa ttggacaaac tacctacaga gatttaaagc tctaaggtaa atataaaatt tttaagtgta taatgtgtta aactactgat tctaattgtt tgtgtattt agattccaac ctatggaact gatgaatggg agcagtggtg gaatgccttt aatgaggaaa acctgttttg ctcagaagaa atgccatcta gtgatgatga ggctactgct gactctcaac attctactcc tccaaaaaag aagagaaagg tagagaccc caaggacttt ccttcagaat tgctaagtt tttgagtcat gctgtgttta gtaatagaac tcttgcttgc tttgctattt acaccacaaa ggaaaaagct gcactgctat acaagaaaaat tatggaaaaa tattctgtaa cctttataag taggcataac agttataatc ataacatact gttttttctt actccacaca ggcataggt gtctgctatt aataactatg ctcaaaaatt gttaccttt agctttttaa tttgtaaagg ggttaataag gaatatttga tgtatagtgc cttgactaga gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcatttt ttcactgcat tctagttgtg gtttgtccaa actcatcaatgtatcttatc atgtctggat caactggata actcaagcta accaaaatca tcccaaactt cccaccccat accctattac cactgccaat tacctagtgg tttcatttac tctaaacctg tgattcctct gaattatttt cattttaaag aaattgtatt tgttaaatat gtactacatt ct aaagaagaca agatatcctt gatctgtgga tctaccacac acaaggctac ttccctgatt agcagaacta cacaccaggg ccaggggtca gatatccact gacctttgga tggtgctaca agctagtacc agttgagcca gataaggtag aagaggccaa taaaggagag aacaccagct tgttacagcc tc gagagaagtg ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg gagtacttca agaactgctg atatcgagct tgctacaagg gactttccgc tggggacttt ccagggaggc gtggcctggg cgggactg cggccgc gcagctgctt tttgcctgta ctgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccct gcacctctt gcagcgtta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag cgcgcacggcaagaggcgag gggcggcgac tggtgagtac gccaaaaatt tgactagcg gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcgggg agattagat cgcgatggga aaaaattcgg tttaggccag taggagataaaaggagatacaataa ctagaacgat tcgcagcctg ttagaaacat cagaaggctg tagacaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatatat acagtagca ccctattg tgtgcatca aggataga tagagacaaggactagacacaca agtaagacca ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag ggacaatttgg agaagtgaat tataatata taaagtagta aaaattgaac cattaggagt agcaccacc aaggcag gagagtgt gcagagagaa aaagagcag tggggttgactc tgggattacgt agggct aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gaggcttatt gaggcgcac agcatgtt gcaactcaca gtctggggca tcaagcacc tcaggtagcacc atcct tgggatttg gggttgctt ggaaaactca ttgcaccac tgctgtgct tggaatgcta gttggagtaa taaatctg gaacagattt ggaacacacgacctggatg gagtgggaca gagaattaat cattacaca agcttaatac actccttaat tgagaatcg caaaccagc aagaaagaa tgaacagaa ttattggaat tagataatg ggcaagttg tggaattgt ttacataac aaattggctg tgtatagtaa aggattagttagtta atagttttt gctgtacttt ctatagtga tagagttagg cagggatatt caccattatc gttcagacc cacccacca ccccgagggg acccgacagg cccgaagga tagagaga agggagag agagacagag acagatccat tcgattagtg aacggattc aaccaggcatcatc aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaagaat agtagacata atagcacag acatacaac tagaaaaaaa ttacaaaat tcaaatttt cgggttatt acagggacag cagagatcca ctttggctga tacgcagcaccaccccc agcatgcctg ctattgctt cccaatcctc ccccttgctg tcctgcccca cccacccc cagaatagaa tgacacctac tcagacaatg cgatgcatt tcctcatttt attaggaag gagtggga gtggcacctt aagggtca ggaggacaggcaggcg cagtcgaggc tgatcagcga gcttaggga tccatcacc acttgtaca agaagctgg gtggtaccgc ggagacatga taagatacattgatgagttt ggacaaacca caacgaat gcagtgaaaa aaatgcttta ttgtgaaat tgtgatgct attgctttat ttgtaccat tataagctgc ataaacaag tccgcggtc gacctacct tcccacacat acccgctggg caagagct cgctcagtgattgccta ciettgcttt aatccctgga tgcaagtcaa gcaggacttg ccggcagcga ccacaggag aaggattcc ccggttttca ttcaattg cgacaatgca cgtaggttc ccgcagcag cagcagcggc agtgcccat acacgagtt ctcgccacctaccgt ggtaaatatg cggccatcag aactgagagc agcggaagcg acgctatagt cctcagaaat aggaatgcta ttaatcgtgg cagtcgccct cttataagg gtagactcct cttgactaag cggcttagcc atgtcgactg gtccaggattca gtcaccagctagctag gttgccccag aacctgccaa tattcgctca cagagacgcc accccgtgac gccattaatt gtcaccctaa acagagact tccatctgga ttaatagtc ttcatcat tatcttattt ccattccaga gtgtgccggt cacggttatt tattcgct a caaccagaccggc tatcatattg ggggtgactc catcaataac aagggttccg taatgcaata ttactttgaa atggtggtca tcgacgggat atacaactt gatatcttc tcaatttgtc ccatctgatc acctgaaagcccctcgtagg gtataattac gtgaatatca attttaagtc cgttctctcc agacacacg attcgctgta tggtgtcac gctactcca aggttgga agagagaga gacgccacct tgttccaca cctgatcgag attataccca gcggttgtc gccaatctct tcacctagctc tacaagctc ttataatcgg tgatatcgtc agtcattcgc tttctttcc tcctcaggac cagggctt tgaagatga gatgcccac aagggacac aggcagaga tcagataagc CAagtcaca gctgagacct tccagccacc agtcctcagc agccagcaggttg atggagtagcc ggtcaggttg ccacggtgac ataatactt tccagcgtct tgagctgtgg cccggggcaa caacagaccc gtctcatta cccacatatc tctgccggg cgatcgtcct tcagcttag gctcagcat gacttaggcc ccttggggtg cacagtgggggg gggggtaccc cacaggacag ccagagtgtg gagccagggg ccatggtgag gtcctggctg aggctctggt tcaggctc cctcggtggg agacacggag gctctcctc ccagatctca gggcggtctt tggcccac atacagctgtgtg gggctgt aggacctgtt cttcaggcca cagcccaggc cacctaggtc cgaacattc caccgacaca gcccgct gccccaca tgactgtcc agccaggctg ccaggccttc tcagaggggg gccccggctggcacaggtag aagcccccca tctgttgaga gacgttgaag atgaaagcc agatggccag gggcctcatg tggattccca gggctggcag cccaggctg agttttaaga agggttaag cggggactcc cgagaccagg tcagctgctg agtggggcca tccgttgaggcagcag cctcttccac cttcaccact agaggttcct cgggcctgac ttccatgggg gtgaggaaga ggaggaagaa gaggaggcga ggaggtggca tgatatcggg ccctggtc tctcacat ctccacaagt gagcagtgag cccgcctt ccaggattacgattg aaccattagagttgg agtactccat ggtaccagcc tgcttttg tacaacttg ttgatggct cgagacctag aaaaaacatgg agcaatcaca agtagcaata cagcagctac caatgctgat tgtgcctggc tagagcaca agaggaggag cagggagctt ttccagtcac acttagactaggta c gccacttttt aaaagaaaag gggggactgg aagggctaat tcactccaa cgaagacaaa atcgtcgaga gatgctgcat ataagcagct gctttgct tgtactgggt ctctctggtt agaccagatc tgagcctgg agctctgg ctactaggg attaaccactca attaagccactc ttcaagtagt gtgtgccgt ctgttgtgtg actctggtaa ctagagatcc tttagtcagt gtggaaaatc tctagcagta gtagttcatgtcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggcc ttgacattat atagattta gcaggaattg actaggagt ggagcacaca ggcaagctg cagaagtact tggagagc caccagagat actcacgatt ctgcacatac taggaagc ctcagatctac aacatttata taatgattta tagtttaag tataaactta tctaatttac tattctgaca gatttaatt aatcctcaa tatcataaga gatgattact attcccca ttacaca gaggaactg agagggaag atgttgaagt aattccca cattacagc atccgttagt tacaatgactcactcccta actcagtcga atattacaa gttatggaca ttatgctaag taacaaatta ccctttata tagtaatac tgagtagatt gagagaa attgtttgca aacctgaata gcttcaagaa gagagaagt gaggataga attackacagttg tcattcaca agttttaaca agtagtagtag attagtagtgg ttctggcaac aagactatac taaatatgac ttcaataat tgttggaact tgataaact aattaaatat tattcaatatt aataatgta tttacttta aaagggaac atagaatgt gtacattag agtagaaac aatccttatt gatacaattaatt gttcagtag gtcaag tcattag tgactgcag atttgtgttttgttaaaat tagaagaga taacaacaat ttgaattatt gaaagtaaca tgtaaatagt tctacatacg ttcttttgac atcttgttca atcattgatc gaagttcttt atcttggaag aatttgttcc aaagactctg aaatagga aacaatctat tatatagtct cacacctttg ttttactttt agtgatttca atttaataat gtaaatggtt aaaatttatt cttctctgag atcatttcac attgcagata gaaaacctga gactggggta atttttatta aaatctaatt taatctcaga aacacatctt tattctaaca tcaatttttc cagtttgata ttatcatata aagtcagcct tcctcatctg caggttccac 3-6 Sequences 3-6-1 Sequence Number [ID] 6 3-6-2 Molecule Type 3-6-3 Molecule Type 3-6-3 Sequence Number [ID] 3-6-2 Molecule Type 3-6-3 Lenqth 1101 3-6-4-1 Features Location / Qualifiers mol_type= other DNA organism» synthetic construct NonEnglishQualifier Value 3-6-5 Residues cggctgaggg cggggacagg ggtgcggcgg acccactgct cccattaccc gaccagcgcc acatccggga gagccggtcc gtttctcagg cagactaggc cattaggtgc ctcggagaaa ggacccaagg ctgctccgtc cttcacagac acagtccaat cagagtttcc caggcacatc tccgaccaat ctcgcaccgc ccagagcggg cccttcctgt caattaccta ctgaagggca caccctgccc tctgattggt ccaaggaagg ctggggggca ggacgggagg cgaaacccct gggtctccac gacgacttat aaaagccgag gggcgcgcgg tccggaaaac ggccagcctg aggagctgct gcgagggtcc gcttcgtctt tcgagagtga ctcccgcggt cccaaggctt actgagctct tgtcgcggat cccgtccgcc gtttccagcc cccagtctca gagcggagcc cacagagcag ggcaccggca t 3-7 Sequences ■■■ Sequence Number [ID] 3-7-2 Molécule Type DNA 3-7-3 iiiM 3-7-4-1 Features Location / Qualifiers source 1..813 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-7-5 Residues gtgaggcctg caagctccgg gcgcctggcc tacctaactc agccccgcag tctctgcaga accccctgca gccccgtggc ccagtttctc catttgctca caatggccaa cggcgtgagg cacttgagcg gaatgcggac ggtgcctccg acagctttcc cgcagtgcat gatctcagga ggggccccagagacggaagt ttacgacgcc cagagcgctc cttctggacg tgccctggac tcgacttggg actgagtctg tgccgcctag gctggcaggg actcggccag atgcactagc ggcaaggctg ggctgacacc gcctgggact cgctcgccgt acctccaagg ggcccaggtc atgagggggc ggctggggag acgcccgccc ggtgcccgcc ctgggcccgg cgggtgcccc ctgcccgccg cctgacgcaa tccgaggcgc ccttgctgca tgccggcgct ggagaaacct cccctgccgt tgcatcactc ctgccaggtt tgccacagag gtggagctga accaatcagc gggcgcgctg ggcccgcggc gcggttaagt gagaagcaga atccgaagtt gattggccaa aaggggattt gccccacccc aatcaccgcg gcagctggcc gcggtgggcg tggtctcccg gcaagaaggt ttaaagggcg cctccatggg gggcgctcag ctggagctac cgagcggtgc caggccaggt gtgtgcgtcc gtcggtcttt ccgtgcccac gccggagacc agccccggag gccgcctggg cctatccctg tgccaggcac cat 3-â Sequences 3-8-1 Sequence Number [ID] 8 3-8-2 Molécule Type DNA 3-8-3 Lenqth 1833 3-8-4-1 Features Location / Qualifiers source 1.,1833 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-8-5 Residues caggaccctg ggggttacaa cctccactcc agctcccctc tgaacctgtg cttttcctct cccttaaatc atgtcaggct caccagctga cggagagaaa aatcatcctt tgtagcttg aaaaacgtgt ctgaatcctg atggtggttc ttccgcctc iiiiiiijillgiiiilgiiiooo gaagggtgtg tagcaaagtg agccccacgc atgcgtagac tcttccctcg gcttctgctc ggtgcgctg gcgcaggcgg tgacagggag acaccgccgc cactgagtat tcctatgcaa gtttctcat cttcgttg atccaggatt aggaacggcg tcctggcccg ctcggggcc gcgcacgccg ccaccaagcc gcgggggcgg gtcggagggg agagttgcgt cagccaggcc gctgtcagat gacgagcccg gggcgtgacg gggtggagca tccccaaaaa agtgcatgcc tagcggcgcgcgcgcgcgcgc ggcgggccgg gctgggcagc tttataaaca gccgtggtgt gagcctcgaa gggaaccatc agcgcctcct gtccacggag ctccaggtct acaatctcga gccaccatgg tgagcaaggg cgaggagctg itiOiiiiiiiiiiO agcgtgtccg gcc gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccgaggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg gggatcactc tcggcatgga cgagctgtac aag 3-9 Sequences iiaiii Sequence Number 0D1 3-9-2 Molécule Type DNA 3-9-3 3-9-4-1 Features Location / Qualifiers source 1..996 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-9-5 Residues atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc aagaacgtga cagatgagca ggagggcttc gccgagggct tcgtgcgcgc cctggccgaa ctgcacagcc agaacacgct gcccagcgtcacgtcggcgg cgcagccggt caacggggca ggcatggtgg ctccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc gccagcctgc acagcgagcc gccggcctc gcaacttca gcaacttca cccagggcccc gccctcctac gccgcggccg tccgcgcca cccagcagc agcagcagcc gccgcaccac ctgcccagc agatgcccgt gcagcaccg cggctgcag cctgaagga cggagcctcag acagtgcccccg agagcgccg ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagaat cgcccggctg gaggaaaag tgaaacctt gaagctcag aaggcccaggacaccac t aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc caactcatgc taacqcagca qttqcaaaca tttqa 3-10 Sequences 3-10-1 Sequence Number [ID] 10 3-11-2 Molecule- Type-1th AA 3 3 3-10-4-1 Features Location / Qualifiers source 1..331 mol_type= protein organism= synthetic construct NonEnglishQualifier Value 3-10-5 Residues LTSPDVGLLK UXSPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GIWAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F 3-11 Sequences iiliiliil Seguence Number 0D] 3-11-2 Molécule Type DNA liliillli 3-11-4-1 Features Location / Qualifiers source 1..69 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-11-5 Residues ggatccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga agaaaacccc ggtcctcat 3-12 Sequences 3-12-1 Seguence Number [ID] 12 3-12-2 Molécule Type DNA 3-12-3 Length 137 3-12-4-1 Features Location / Qualifiers source 1.,137 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-12-5 Residues gtcgaûaâct tgtttattgc agcttataat ggttacàaat aaâgcaatàg càtaâcaaat 3-13 Sequences 3-13-1 Seguence Number [ID] 3-13-2 Molécule Type DNA 3-13-3 liliBlllM 3-13-4-1 Features Location / Qualifiers source 1..1135 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value. 3-13-5 Read more gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcggggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aagggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg ctggccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa aggaaaaggg cctttccgtcctcagccgtc gcttcatgtg actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttc 3-14 Sequences 3-14-1 Sequence Number [ID] 14 3-14-2 Molécule Type DNA 3-14-3 Length 1458 3-14-4-1 Features Location / Qualifiers source 1..1458 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-14-5 Residues atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca tactataatt cagctctcaa atccagactgaccatcatca aggacaactc caagagccaa iliiiBiiiiiiiiiiiiiM cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc gtctcctcaa ccactacccc agcaccgagg ccacccaccc cggctcctac catcgccgtcc cagccgctc agacccgcag ctggtggggc cgtgcatacc cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg tacatcttta agcaaccctt catgaggcct gtgcagacta ctcaagagga ggacggctgt tcatgccggt tcccagac tgcgcgtgaa attcagccgc agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga actcaatctt ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc gggaagccgc gcagaaagaa tcccggc aaaggataag atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg caggccctgc cgcctcgg 3-15 Sequences liiOiiIIDMii Number 3-15-2 Molecule Type DNA 3-15-3 3-15-4-1 Features Location / Qualifiers source 1..720 mol_type= other DNA organism= synthetic constructNonEnglishQualifier Value 3-15-5 Residues atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca tqgacgagct gtacaagtaa 3-16 Sequences 3-16-1 Sequence Number [ID] 16 3-16-2 Molécule Type DNA 3-16-3 Lenqth 5822 3-16*4*1 Features Location / Qualifiers source 1..5822 mol_type= other DNA organism» synthelic constructNonEnglishQualifier Value 3-16-5 Residues tggaggcaag gcctgcaaaa tgcaatactg caagcattg ggagtcagac tcccatcagg tgtctggttc gagatggctg ataaggatct ctttgctgca gccagattcc ctgaatgccc cgttgagatt atcctcctc tggagcaaaa tcagagcggg tcttccaatc tctccagtgg atctcagcta tcttgctcct aaaaacccag gaaccggtcc it tattgctgct ccaatcctct caagaatggt cggaatgatc agtggaacta ccacagaaag cgatcttcat cttagctcaa aggctcacctc aagacgctgc taaattaaag cacaccaaga aaagacagat ttatacagac atagagatga accgacttg aaaacggaat tcaccccacc agtgcaggct gcctatcaga aagtggtggc tggtgtggct lOiiiiiiiiiiiiiiiiiO ggctgcaaac agctaatgca agggcccccccct gttcattagcct ctgcatctct cagccttgac tccacfcagt tctcttgctt âgâgâtàcca cctttcccct agttgtctct gttgtcttat agaggtctac ttgaagaagg aaaaacaggg ggcatggttt gactgtcctg tgagcccttc ttccctgcct cccccactca cagtgaccctcgcgcgcgc tgcggccgca gatctgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttatccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg iilliitiilf tiiiiiiiiiiiiiiilOiiii acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct gtteatccat agttgcctga ctecccgteg tgtagataac tacgatacgg gagggcttac cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccataca gtetattaat tgttgccggg aagctagagt aagtagttcg ccagttaata glllgcgcaa cgllgllgcc allgclacag gcalcglggl glcacgclcg Lcglllggla tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gatgcttttc tgtgactggt gagtactcaa ccaagtcatt cîgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtoaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtggat cccctgaggg ggcccccatg ggctagagga tccggccteg gcctotgcat aaataaaaaa aafiagtoag aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt gcagtacate aatgggcgtg gatagcggtt tgacteacgg ggatttccaa gtetecaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactac gccccattga. cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgteagat cgcctggaga cgccatccac gctgttttga cctccataga agacaccggg accgatccag cctcccctcg aagcttacat gtggtaccga liiiliBliiiiiii® cttttctatg gttaagttca tgtcatagga aggggagaag taacagggta cacatattga gggataaggc tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc 111111111011111^^^ ttattcattg gggtgaattg caagttcacc atagtttttc cacacaacca aaaaggaac llliiiliM aatgacttaa taggcacagc cttacaagtc aaaatgccca agagtcacaa ggctattcaa gaaagcattg aacaaacgaa acaaggaact tggcÈgaatc caggcttccc tactcaaagt tgtggatatg caactgtgac ggatgccgaa gcagtgaftg tocaggtgac tccteaccat gtgctggttg atgaatacac aggagaatgg gttgattcac agttcatcaa cggaaaatgc agcaattaca taigccccac tgfccataac tetacaaect ggcattctga ctaaggtc gagctateat ccctgggaa ggagggcaca gggttcaga gtaactactt tgcttatgaa -ae----------------------------------------------------------------------------------------------- 3-17 Sequences 3-17-1 Sequence Number [ID] 3-17-2 Molecule Type DNA 3-17-3 8Ô90 3-17-4-1 Features Location / Qualifiers source 1..8890 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value; 3-17-5 Residues gtccaacatt accgccatgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca ccgggaccga tccagcctcc cctcgaagct tacatgggtc acttcagggt gagtctatgg gacccttgat gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta ttcattaactcttcttc atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc ttttatttta tgggact agattgacttaggt cccttttgct aatcatgttc ataccctta tcttcctccc acagctcctg ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagcacgtga gatctgaatt cgagatctgc cgccgccatg ggtgcgagag cgtcagtatt aagcggggagatc gaaagaaaaa atataaat aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgttagaaacatcag aaggctgtag acaatactg ggacagctac aaccacatccct tcagacagga tcagagaac ttagatcatt atataca gtagcaaccc tctattgt gcatcaagg atagata aagacaccaa ggaagcttta gaagatag aggacacaacagaagca aagacacaacagaag acaggacaca gcaatcaggt cagccaaaat tacctatag tgcagaacat ccaggggcaa atggtacatc aggcatatc acctagaact ttaatgcat gggtaaagt agtagaagg aaggcttca gcccagaagt gatacccatg tttcagcat acccaccacagagt aaccca gggggacatc aagcagccat gcaatgtta aaagagacca tcaatgagga agctgcagaa tgggatagag tgcatccagt gcatgcaggg cctattgcag caggcagat gagagaacca agggagtg acatagcag aactactagt acccttcagg aacaatacgac caccacat atggat tataaaagat gggattaatcct aaaatagtaa gatgtatag ccctaccagc attctggaca tagacaagg accaaggaa ccctttagag actagtaga ccgattctat aaaactta gagccgagca agcttcacaca gaggtaaaa attggacgattg agattacaccac actattttaa aagcattggg accaggagcg acactagaag aaatgatgac accatgtcag ggagtgggggacccggcca taaagcaaga gttttgctg aagcaatgag ccaagtaaca aatccagcta ccataatgat acagaaaggc aattttagga accaaagaa gactgttaag tgttcaatt gtggcaaga agggcacata gccaaaatt gcagggcc taggagaggattacag atgggaggattacag at haaatgaaag attgtactga gagacaggct aattttag ggagatctg gccttcccac aagggaggc cagggaattt tctcagagc agaccagagc siacagcccc accagag agctcaggt ttgggaga gacacactc ccctcaga agcaggacct gacagactcactc gacagacagc ctctttggca gcgacccctc gtcacataa agataggggg gcaattaag gaagctctat tagatacagg agcagatgat acagtattag aagaaatgaa tttgccagga agatggaaac caaaatgat aggggaatt ggaggtttta cacaagtag acagtagat gtcatactcagtaggatagataact aggacctaca cctgtcaaca taattggaag aaatctgttg actcagattg gctgcacttt aaatttccc attagtccta tgagactgt accagtaaa ttaaagccag gatggatgg cccaaagtt aaacaatgc cattgacaga gagaaaaata aaggaaattgaattag tagacaga gaaaaatttc aaaaatttggg cctgaaaatc catacaatac tccagtattt gccataaga aaaagacag tactaaatggagaaaattag tagattcag agaacttaat agagaactc aagatttctg ggaagttca ttaggaatac cacatcctgc agggttaaaa cagaaaaaat cagtacagt actggatg ggcgatgcat attttcagt tcccttagat aagattactactcatcagtag ggataag gandaccaggg attagatatc agtacaatgt gcttccacag ggatggaaag gatcaccagc atattccag tgtagcatga caaaaatctt agagcctttt agaaaaaaa atccagacat agtcatctt caatacatgg atgatttgta tgtaggatct gactagagacaaga ataggacaca taggcacaa tctgttgagg tggggattta ccacaccaga caaaaaacat cagaaagac ctccattcct ttggatggt tatgaactc atcctgata atggacagta cagcctatag tgctgccaga aaggacagc tggactgtca agacataca gaattagtg tggagattagtag atcagattagtagtga attatgtaaa cttcttaggg gaaccaaagc actaacagaa gtagtaccac taacagaga agcagagcta gaactggcag aaaacaggga gattctaaaa gaaccggtac atggagta ttatgaccca tcaaagact taatacagag caggggttcaat atatagaacat gccaatgga tctgaaaaca ggaagtag caagaatgaa gggtgcccac actaatgatg tgaacaatt aacagaggca gtacaaaaaatagccacaga aagcatagta atatggggaa agactcctaa attaaatta cccatacaaa aggaaacatg ggaagcatgg tggacagagt attggcaagc cacctggatt cctgagtggg agtttgtcaa tacccctccc ttagtgaagt tatggtacca gttagagaaa gaacccataa taggagcactc ggaaactaaa ttaggaaaag caggatatgt aactgacaga ggaagacaaa aagttgtccc cctaacggac acaacaaatc agaagactga gttacaagca attcatctag ctttgcagga ttcgggatta gaagtaaaca tagtgacaga ctcacaatat gcattgggaa tcattcagt cagacagat cagtcaaata atagagcagt tataaaaaa ggaaaaagtc tacctggcat gggtaccagc acacaaagga attggaggaa atgaacaagt agataaattg gtcagtgctg gaatcaggaa agtactattt ttagatggaa tagataaggc ccaagaagaa catgagaaat atcaggta ttagactgtca atgattacttagtca accacctgta gtagcaaaag aatagtagc cagctgtgat aaatgtcagc taaaagggga agccatgcat ggacaagtag actgtagccc aggaatatgg cagctagatt gtacacattt agaaggaaaa gttatcttgg tagcagttca tgtagccagt ggatatatag aagcagaagagt aatacctcagcagc ttaaaattag caggaagatg gccagtaaaa acagtacata cagacaatggcagcaatttc accagtacta cagttaaggc cgcctgttgg tggcggga tcaagcagga atttggcatt ccctacaatc cccaagtca aggagtaata gatctatga ataagaatt aaagaaatt ataggacagg taagagatca ggctgaacat cttagacag cagtacaaat tggattacaatt tggattacaatt ggggggtaca gtgcagggga aagatagta gakataatag cacacacat aaactaaa gattacaaa aaaaattac aaaaattca aattcggg tttacag ggacagcaga gatccagttt ggaaggacc agcaagctc gtgaaggg gtgaaggcaga caactagatag agaagaaaag caagatcat cagggatt ggaaaacaga tggcaggtga tgattgtgtg gcaagtagac aggatgagga ttacacatg gattccgga gcggccgcag gagcttgtt ccttggttc tcagggagcag cggagcac tattggcaccacgatca gc ctggtatagt gcagcagcag aacaatttgc tgagggctat tgaggcgca cagcatctgt tgcaactcac agtctggggc atcagcagc tccaggcag aatcctggct gtggaagat acctaagga tcacagctc ctggggattt tggattcaccagct ttggaatgct agttggagta ataatctct ggaacagatt tggaatcaca cgacctggat ggagtgggac agagaatta acattacac aagcttccgcggaattcacc ccaccagtgc aggctgccta tcagaaagtg gtggctggtg tggctaatgc cctggcccac aagtatcact aagctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat gtgggaggtc agtgcattta aaacataaag aaatgaagag ctagttcaaa ccttgggaaa atacactata tcttaaactc catgaaagaa ggtgaggctg caaacagcta atgcacattg gcaacagccc ctgatgccta tgccttattc atccctcaga aaaggattca agtagaggct tgatttggag gttaaagttt tgctatgctg tattttacat tacttattgt tttagctgtc ctcatgaatg tcttttcact acccatttgc ttatcctgca tctctcagcc ttgactccac tcagttctct tgcttagaga taccaccttt cccctgaagt gttccttcca tgttttacgg cgagatggtt tctcctcgcc tggccactca gccttagttg tctctgttgt cttatagagg tctacttgaa gaaggaaaaa cagggggcat ggtttgactg tcctgtgagc ccttcttccc tgcctccccc actcacagtg acccggaatc cctcgacatg gcagtctagc actagtgcgg ccgcagatct gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcaggggataacgcagg aagaacatg tgagcaaag gccagcaaaa ggccaggaac cgtaaaagg ccgcgttgct ggcgttttc cataggctcc gccccctga cgagcatcac aaaaatcgac gctcagtca gaggtggcga aacccgaccacg gactaag cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctccctc gggaagcgtg gcgctctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctggcaccgactcacc t gcgccttac cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tctcgagtg gtggcctaac tacgggactact aggcgagtagtctag agttaccttc ggaaaaagag tggtagctc ttgatccggc aaaaaaacca ccgctgctc cggtggtttt tttgttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaga tccttgatc tttctacgg ggtctgacg tcagtagtggatgac agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaagta tatatgagta aacttggtct zgagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccccgtcgtgtag atatacga tacgggagg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagatg gttcgcacagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc tttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaa gtgctcatca ttggaaaacg ttctcgggg cgaaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttccttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtgccacctgacg tggatcccct gagggggccc ccatgggcta gaggatccgg cctcggcctc tgcataaata aaaaaaatta gtcagccatg agcttggccc attgcatacg ttgtatccat atcataatat gtacatttat attggctcat 3-18 Sequences 3-18-1 Sequence Number [ID] 18 3-18-2 Molécule Type DNA 3-18-3 Lenqth 2748 3-18-4-1 Features Location / Qualifiers source 1..2748 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-18-5 Residues cacaaggcta cttccctgat tagcagact acacaccagg gccaggggtc agaatccac tgacttgg atgtgctac aagctactac cagtgagcc agataggta gagaggcca atacagcctt t gagacact gcatgggatg gatgacccgg agagagaagt gttagagtgg aggttgaca gccgcctagc atttcatcac gtggcccgag ctgggactt tccagggagg cgtggcctgg gcgggactgg ggagtggftgag gccctcagat cctgcatata ttcagcggcctgct ccagafctga agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacttgaag agagggcga ggggcggcga ctggtgagta cgccaaaat ttgactagc ggagggactga caagcaggga gctagaacttat tcattaggaccca gtagacaaat actgggacag ctacaaccat cccttcagac aggatcagaa gaacttagat cattatataa tacagtagca acctatt gtgtgcatca aaggatagag aaaagaca ccaaggagc tttagacaag atagaggaag agcaaacaa aagtaagacc attagataagtaacaacac ccattaggag tagcaccac caagcaag cattattgt ctggtatagt gcagcagcag aacaatttgc tgaggctat tgaggcgca gtggaaagat acctaagga tcacagctcctggggattt ggggttgctc tggaaaactc atttgcacca ctgctgtgcc tggaatgct agttggagta ataatctct ggaacagatt tggaatcaca cgacctggat ggagtgggac agagaatta acattacac aagcattata cactccgaa gcaagacaaccaaccag attattggaa tctatagtga atagagttag gcaggtat tcaccattat cgtttcagac ccacctccca gabagatcca tcgattagt gaacggatct cgacggtac gccgaattca caatggcag ttcaattt tcggcttat tacagggaca gcagagatc ccgttcagctg ccgttcgctg cggtaccggt gaagggggcg gccgcggagc ctgcttttt acagcagcta ccaatgctga ttgtgctgg ctagaagcac agaggagga ggaggtggt agccacttt taaagaaaa gggggactg ggcactactta acttaca tgtggaaaat ctctagca 3-19 Sequences iiiiii Sequence Num ber 0D1 3-19-2 Molecule Type DNA 3-1Ô-3 2598 3-19-4-1 Features Location / Qualifiers source 1..type=2598 other DNA organism NonEnglishQualifier Value 19-3-2020 gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcggggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aagggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg ctggccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa aggaaaaggg cctttccgtcctcagccgtc gcttcatgtg actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gttccccac actgagtggg tggagactga agttaggcca gcttggcat t ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttctcgag atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgacaca gactacatcc tccctgtctg cctctggg agtaaatatt taaattggta tcagcagaaa ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag caagaagata ttgccactta cttttgccatag cagggcttagcgc ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtg gtcgggtggc ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca catgcactgt ctcaggggtc tcattacct actatggtt aggcgtcg cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaagtttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc gtctcctcaa ccactacccc agcaccgagg ccacccaccc cggctccctacctcgtcctc ca ccctgcgtcc ggaggcatgt agacccgcag ctggtggggc cgtgcatacc cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg gtcctgctgc tttcactcgt gatcactctt tagggtaagc gcccgctcgcgctt tactgc catgaggcct gtgcagacta ctcaagagga ggacggctgt tcatgccggt tcccagagga ggaggaaggc ggctgcgaac tgcgcgtgaa attcagccgc agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga g actcaatctgagg agtacctcggagg aagcggagag gacgggaccc agaaatgggc gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac gacggactgt accagggact cagcacc accac tcttcacatg caggccctgc cgcctcgg 3-20 Sequences 3-20-1 Sequence Number [ID] 20 3-20-2 Molecule Type DNA 3-20-3 Lenqth 1737 3-20-4-1 FeaturesLocation / Qualifiers source 1..1737 mol_type= other DNA orgamsm» synthelic construct NonEnqlishQualifier Value 3-20-5 Residues ctccggtttg catcacccgg accgggggcc gggcgcgtcc tagctatag ctccggtttg catcacccgg accgggggat tagctccggt ttgcatcacc cggaccgggg gattagctcc ccgagcgacc ctgcagcgac ccgcttaact cgagctagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc cggacatcca gatgacacag actacatcct ccctgtctgc ctctctggga gacagagtca ccatcagttg cagggcaagt caggacatta gtaaatattt aaattggtat cagcagaaac cagatggac tgttaaactc liigiiiiilBiiiiiiiiiiM ■iiiiiliiiiiiiM caggagtcag gacctggcct ggtggcgccc tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc aagagccaag ttttattaaa aatgaacagf tatgçtatgg açtactgggg cçaaggaaçç teagtcaccg tctcçtcaaç çaçtaççççça gcaccgaggc cacccacccc ggctcctacc atcgcctccc agcctctgtc cctgcgtccg atgaggcctg tgcagactac tcaagaggag gacggctgtt catgccggtt cccagaggag gaggaggcg gctgcgaact gcgcgtgaaa ttcagccgca gcgcagatgc tccagcctac gtgctggacaagcggagagg acgggaccca gaaatgggcg ggaagccgcg cagaaagaat ccccaagagg gcctgtacaa cgagctccaa aaggataaga tggcagaagc ctatagcgag oillllllliflllllfliliilflflllllio agcaccgcca ccaaggacac ctatgacgct cttcacatgc agqccctqcc qcctcqq 3-21 Sequences 3-21-1 Sequence Number [ID] 3-21-2 Molécule Type DNA 3-21-3 996 3-21-4-1 Features Location / Qualifiers source 1..996 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-21-5 Residues tttgcatcac ccggaccggg ggattagctc cggtttgcat cacccggacc gggggattag ctccggtttg catcacccgg accgggggcc gggcgcgtcc tagcgattag ctccggtttg catcacccgg accgggggat tagctccggt ttgcatcacc cggaccgggg gattagctcc ggtttgcatc acccggaccg gggacttcgc atattaaggt gacgcgtgtg gcctcgaaca ccgagcgacc ctgcagcgac ccgcttaact cgagctagca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccgctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc qccqqqatca ctctcqqcat qqacqaqctq tacaaq 3-22 Sequences 3-22-1 Sequence Number [ID] 22 3-22-2 Molécule Type DNA 3-22-3 Lenqth 2787 3-22-4-1 Features Location / Qualifiers source 1.2787 mol_type= other DNA organism= synthetic construct Non EnqlishQualifier Value 3-22-5 Residues tttgcatcac ccggaccggg ggattagctc cggtttgcat cacccggacc gggggattag ctccggtttg catcacccgg accgggggcc gggcgcgtcc tagcgattag ctccggttg catcacc tagggcat accggcat ttcggg cggaccgggg gattagctcc ccgagcgacc ctgcagcgac ccgcttaact cgagctagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc cggacatcca gatgacacag actacatcct cctgtctgc ctgctgc cagggcaagt ctgatctacc atacatcaag attacactca ggagtcccat caaggttcag tggcagtggg acaggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctga ggtgaaactg caggagtcag gacctgcct ggtggcgcc tcagcgc tc tcaggggtct cattacccga ctatggtgta agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt gaaaccacat actataattc agctctcaaa OlllllllllllllilillliBi® tatgctatg actactgggg ccaggaacc tcagcacct caccct tgcacctac gacccgcagc tggtggggcc gtgcataccc ggggtcttga cttcgcctgc gatatctaca tttgggcccc tctggctggt acttgcgggg tcctgctgct ttcactcgtgatgaggcctg tgcagactac tcaagaggag gacggctgtt catgccggtt cccagaggag gaggaaggcg gctgcgaact gcgcgtgaaa ttcagccgca gcgcagatgc tccagcctac gtgctggaca agcggagagg acgggaccca gaaatgggcg ggaagccgcg cagaaagaat attggtatga aaggggaaçg çagaagaggç aaaggççaçg- açggaçtgta ççagggaçtç agcaccgcca ccaaggacac ctatgacgct cttcacatgc aggccctgcc gcctcgggcc gcaaagatgg aaacgacctt ctatgacgat gccctcaacg cctcgttcct cccgtccgag agcggacctt atggctacag taaccccaag atcctgaaac agagcatgac cctgaacctg gccgacccag tggggagcct gaagccgcac ctccgcgcca agaactcgga cctcctcacc tcgcccgacg tggggctgct caagctggcg tcgcccgagc tggagcgcct gataatccag tccagcaacg ggcacatcac caccacgccg acccccaccc agttcctgtg ccccaagaac gtgacagatg agcaggaggg cttcgccgag ggcttcgtgc gcgccctggc cgaactgcac agccagaaca cgctgcccag cgtcacgtcg gcggcgcagc cggtcaacgg ggcaggcatg gtggctcccg cggtagcctc ggtggcaggg ggcagcggca gcggcggctt cagcgccagc ctgcacagcg agccgccggt ctacgcaaac ctcagcaact tcaacccagg cgcgctgagc caggccctga aggaggagcc tcagacagtg cccgagatgc ccggcgagac accgcccctgtcccccatcg acatggagtc ccaggagcgg atcaaggcgg agaggaagcg catgaggaac cgcatcgctg cctccaagtg ccgaaaaagg aagctggaga gaatcgcccg gctggaggaa aaagtgaaaa ccttgaaagc tcagaactcg gagctggcgt ccacggccaa catgctcagg gaacaggtgg cacagcttaa acagaaagtc atgaaccacg ttaacagtgg gtgccaactc 3-23 Sequences 3-23-1 Sequence Number [ID] ioiiiiiim^ 3-23-2 Molécule Type DNA 3-23-3 2598 3-23-4-1 Features Location / Qualifiers source 1..2598 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-23-5 Residues tgtcagtggg cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcggggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aagggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg ctggccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa aggaaaaggg cctttccgtcctcagccgtc gcttcatgtg actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gttccccac actgagtggg tggagactga agttaggcca gcttggcat t ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttctcgag atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccggacatcc agatgacaca gactacatcc tccctgtctg cctctggg agtaaatatt taaattggta tcagcagaaa ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag caagaagata ttgccactta cttttgccatag cagggcttagcgc ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtg gtcgggtggc ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc ctgtccgtca catgcactgt ctcaggggtc tcattacct actatggtt aggcgtcg cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaagtttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc gtctcctcaa ccactacccc agcaccgagg ccacccaccc cggctccctacctcgtcctc ca ccctgcgtcc ggaggcatgt agacccgcag ctggtggggc cgtgcatacc cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg gtcctgctgc tttcactcgt gatcactctt tagggtaagc gcccgctcgcgctt tactgc catgaggcct gtgcagacta ctcaagagga ggacggctgt tcatgccggt tcccagagga ggaggaaggc ggctgcgaac tgcgcgtgaa attcagccgc agcgcagatg ctccagccta caagcagggg cagaaccagc tctacaacga g actcaatctgagg agtacctcggagg aagcggagag gacgggaccc agaaatgggc gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac gacggactgt accagggact cagcacc accac tcttcacatg caggccctgc cgcctcgg 3-24 Sequences 3-24-1 Sequence Number [ID] 24 3-24-2 Molecule Type DNA 3-24-3 Lenqth 1724 3-24-4-1 FeaturesLocation / Qualifiers source 1..1724 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-24-5 Residues ctcggttg catcacccgg accgggggcc gggcgcgtcc tagcgattag ctccggtttg catcacccgg accgggggat tagctccggt ttgcatcacc cggaccgggg gattagctcc aactttgtat acaaaagttg ctcgagatggcccccccgcgctc tggccttgct gctccacgcc gccaggccgg acatccagat gacacagact acatcctccc tgtctgcctç tctgggagaç agagtcacça tçagttgcag- ggçaagtcag gacattagta gtaatacgct tccgtacacg ttcggagggg ggaccaagct ggagatcacgcggcggc cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caagc caaactgatg actggggcca aggaacctca gtcaccgtct cctcaaccac taccccagca ccgaggccac ccaccccggc tcctaccatc gcctcccagc ctctgtccct gcgtccggag gcatgtagac gcgaactgcg cgtgaaattc agccgcagccg cagatcagc ggacccagaa atgggcggga agccgcgcag aaagaatccc caagagggcc tgtacaacga gctccaaaag gataagatgg cagaagccta tagcgagattggtatgaaag aggacaccta tgacgctctt cacatgcagg ccctgccgcc tcgg 3-25 Sequences 3-25-1 25 3-25-2 Molécule Type DNA 3-25-3 3-25-4-1 Features Location / Qualifiers source 1..1002 mol_type= other DNA organism= synthetic construct NonEnqlishQualifier Value 3-25-5 Residues tttgcatcac ccggaccggg ggattagctc cggtttgcat cacccggacc gggggattag ctccggtttg catcacccgg accgggggcc gggcgcgtgc tagcgattag ctccggtttg catcacccgg accgggggat tagctccggt ttgcatcacc cggaccgggg gattagctcc ggtttgcatc acccggaccg gggactcgag tctagagggt atataatggg ggccactagt ctactaccag aaagcttggt accgagctcg gatccagcca ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcgacttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc qccqccqqqa tcactctcqq catqqacqaq ctqtacaaqt aa 3-26 Sequences 3-26-1 Sequence Number [ID] 26 3-26-2 Molécule Type DNA 3-26-3 Lenqth 2774 3-26-4-1 Features Location / Qualifiers source 1..2774 mol_type= other DNA organism» synthetic construct Non EnqlishQualifier Value 3-20*5 Residues tttgcatcac ccggaccggg ggattagctc cggtttgcat cacccggacc gggggattag ctccggtttg catcacccgg accgggggcc gggcgcgtcc tagcgattag ctccggttg catcacc tagggcat acccgggat ttcggtg cggaccgggg gattagctcc ggtttgcatc acccggaccg gggactcgag tctagagggt atataatggg ggcctcgagc aactttgtat acaaaagttg ctcgagatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc gccaggcc acccat accagatc tgtctgccfc tcigggagac agagtoaocâ tcagftgcag ggcaàgtcag gacattagtà catcaagatt acactcagga gtcccatcaa ggttcagtgg cagtgggtct ggaacagatt gtaatacgct tccgtacacg ttcggagggg ggaccaagct ggagatcagc ggtggcggcg gatctgaggt gaaactgcag gagtcaggac gagtaatatg gggtagtgaa accacatact ataattcagc tctcaaatcc agactgacca actggggcca aggaacctca gtcaccgtct cctcaaccac tccccagca ccgaggccac gggccctct ggcttocctgcggctg àctcgtgate actctttâct gcgaactgcg cgtgaaattc agccgcagcg cagatgctcc agcctacaag caggggcaga ggagaggacg ggacccagaa atgggcgggaagccgcgcag aaagaatccc caagagggcc gggaacgcag aagaggcaaa ggccacgacg gactgtacca gggactcagc accgccacca aggacaccta tgacgctctt cacatgcagg ccctgccgcc tcgggccacg aacttctctc tgttaaagca agcaggagacac gtggagaaa accccggtcc tatgactgca aagatggaaa cgaccttcta tgacgatgcc ctcaacgcct cgttcctccc gtccgagagc ggaccttatg gctacagttaa ccccaagatc ctgaaacaga gcatgaccct gaacctggcc gacccagtgg ggagcctgaa gccgcacctc cgcgccaaga actcggacct cctcacctcg cccgacgtgg ggctgctcaa gctggcgtcg cccgagctgg agcgcctgat aatccagtcc agcaacgggc acatcaccac cacgccgacc cccacccagt tcctgtgccc caagaacgtg acagatgagc aggagggctt cgccgagggc ttcgtgcgcg ccctggccga actgcacagc cagaacacgc tgcccagcgt cacgtcggcg gcgcagccgg tcaacggggc aggcatggtg gctcccgcgg tagcctcggt ggcaggggc agcggcagcg gcggcttcag cgccagcctg cacagcgagc cgccggtcta cgcaaacctc agcaacttca acccaggcgc gctgagcagc ggcggcgggg cgccgcacca cctgccccag cagatgcccg tgcagcaccc gcggctgcag gccctgaagg aggagcctca gacagtgccc gagatgcccg gcgagacacc gcccctgtcc cccatcgaca tggagtccca ggagcggatc aaggcggaga ggaagcgcatgaggaccgc atcgctgcct ccaagtgccg aaaaaggag ctggagaga tcgcccggct ggaggaaaa gtgaaaacct tgaaagctca gaactcggag ctggcgtcca cggccaacat gctcaggga caggtggcac 3-27 Sequences 3-27-1 Sequence Number flD] iMiiiM 3-27-2 Molecule Type DNA 3-27-3 3-27-4-1 Features Location / Qualifiers source 1..1844 mole_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-27-5 Residues gctgatacgc ggatctaagg tgtcccagac cccaagctag gaatggggag ggaaatggag gaatcccaaa tgccttaagg acggcctaca tactaaggaa aattttttc taactcctgg ttgcagctga gggagcgg tgagggcggg gacagggtg cggcggaccc actgctccca ttacccgacc agcgcctccc ttcctccttg gatgggtgcc cctgtcttgc taagaactgc ctgtttacac aactgctttc cttgtgaaaa tttaaaggct cctattccca gttgttctat ccttgtaggt taaagattat gtcaaaaact atattgcatt atctctttcc ttctccttcc cattaagacg gaaaaaacat ccgggagagc cggtccgttt ctcaggcaga ctaggccatt aggtgcctcg gagaaaggac ccaaggctgc tccgtccttc acagacacag tccaatcaga gtttcccagg cacatcgatg caccgcctcc ttcgagaaac aaggtaactt tcgggttctg gttgtctcca aagtcatccg accaatctcg caccgcccag agcgggccct tcctgtcaat tacctactga agggcaggcg gccagcatcg ccatggagac caacaccctt cccaccacca ctcccccttt ctctcagggc ccctgtcccc tccagtgaat cccagaagac tctggagagt tctgagcaga gggcggcacc ctgccctctg attggtccaa ggaagctgg ggggcaggac gggaggcgaa acccctggaa tattcccgac ctggcagcct catcgagctt ggtgattggc tcagaagggg aaaggcgggt ctccacgacg acttataaaa gccgaggggcgcgcggtccg gaaaacggcc agcctgagga gctgctgcga gggtccgctt cgtctttcga gagtgactcc cgcggtccca aggctttcca gagcgaacct gtgcggctgc aggcaccggc gtgttgagtt tccggcgttc cgaaggactg agctcttgtc gcggatcccg tccgccgttt ccagccccca gtctcagagc ggagcccaca gagcagggca ccggcattcg agccaccatg gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gagaacggc atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccaactac ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcgtgaccgccgc cgggatcact ctcggcatgg acgagctgta caag 3-28 Sequences 3-28-1 Sequence Number [ID] 28 3-28-2 Molécule Type DNA 3-28-3 Lenqth 1540 3-28-4-1 Features Location / Qualifiers source 1.,1540 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-28-5 Residues gtgaggcctg caagctccgg gcgcctggcc tacctaactc agccccgcag tctctgcaga accccctgca gccccgtggc ccagtttctc catttgctca caatggccaa cggcgtgagg ggggccccag agacggaagt ttacgacgcc cagagcgctc cttctggacg tgccctggac tcgacttggg actgagtctg tgccgcctag gctggcaggg actcggccag atgcactagc ggcaaggctg ggctgacacc gcctgggact cgctcgccgt acctccaagg ggcccaggtc atgagggggc ggctggggag acgcccgccc ggtgcccgcc ctgggcccgg cgggtgcccc ctgcccgccg cctgacgcaa tccgaggcgc ccttgctgca tgccggcgct ggagaaacct cccctgccgt tgcatcactc ctgccaggtt tgccacagag gtggagctga accaatcagc gggcgcgctg ggcccgcggc gcggttaagt gagaagcaga atccgaagtt gattggccaa liiiiiiiiiiiiiiiiiiiiO gcaagaaggt ttaaagggcg cctccatggg gggcgctcag ctggagctac cgagcggtgc caggccaggt gtgtgcgtcc gtcggtctttccgtgcccac gccggagacc agccccggag gccgcctggg cctatccctg tgccaggcac cattcgagcc accatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccqccgqg atcactctcq qcatqgacqa gctgtacaag 3-29 Sequences 3-29-1 Sequence Number [ID] liiiiiiiii® 3-29-2 Molecule Type DNA 3-29-3 10373 3-29-4-1 Features Location / Qualifiers source 1..10878 mol_type= other DNA construct=Nonthe construct Value Question 3-29-5 Residues gaattatttt cattttaaag aaattgtatt tgttaaatat gtactacaaa cttagtagtt ggaagggcta attcactccc aaagaagaca agatatcctt gatctgtgga tctaccacac acaaggctac ttccctgatt agcagaacta cacaccaggg ccaggcctc agctagtacc agttgagcca gataaggtag aagaggccaa taaaggagag aacaccagct tgttacaccc tgtgagcctg catgggatgg atgacccgga gagagaagtg ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg gagtactacctcagct agatacgct tgctacaagg gactttccgc tggggacttt ccagggaggc gtggcctggg cgggactggg gagtggcgag ccctcagatc ctgcatataa gcagctgctt tttgcctgta ctgggtctct ctggttagac cagatctgag cctgggagct ctctggc agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctctagcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc aagaggcgag gggcggcgac tggtgagtac gccaaaaatt tgactaggg ggacgacgactagaa taagcgggggg agaattagat cgcgatggga aaaaattcgg ttaggccag ggggaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat tcgcagttaa tcctggctg ttagaacacat cagaaggctg tagacagata gccacaggacat aacttagatc attatataat acagtagcaa cccttattg tgtgcatca aggatagaga taaaagacac caggaagct ttagacaga taggagag gcaaaacaa agtagacca ccgcacagca agcggccgct gatcttcaga cctggaggag gagatatgag ggatagaatgaatgg aga cattaggagt agcacccacc aaggcaaga gaagagtggt gcagagagaa aaagagcag tgggaatagg agctttgttc cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc gagagtgtgtgcattagtc gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg tggaagata cctaaaggat caacagctcc tgggattggggttgctct ggaaaactca ttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt ggaatcacac gacctggatg gagtgggaca gagaattaa caattacaca agcttatac actccttat tgagaatcg tgcaaggaaccagacca tagataatg ggcaagtttg tggaattggt ttacataac aaattggctg tgtataata aattattcat aatgagta ggaggctgg taggtttaag atagttttt gctgtactt ctatagtga taggagttagg cagggatatt caccattatc gttcagacc caccgagggaggcccca acccacagaggccccacc aggtggagag agagacagag acgatccat tcgattagtg aacggatctc gacggtacg ccgaattcac aaatggcagt attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacaag tacacaacaag acatacaatta tcaaatttt cgggtttatt acagggacag cagagatcca ctttggctga tacgcggatc tacgcgtaat tgcaaaatt agttgggcac agtgcaggc cctgtaatcc tagctacttg ggaggctgact caccaccact ttaaaagact cgctcacc ctgaggaggact cagggacc tgggcacag agtagactc agtctcaga aaaaaaaaa aaaagacaa aaagtatta ccaacttgtg ccagccatga ggtctacaacctcgatgctg ccaccctcag gaccctgggg gttacaacct ccactccagc tcccctctga acctgtgctt ttcctctgag cccacattcac tcccacaact gtctcattca ttcactggtt cactcagcct ccaaccaccc ttaaatcatg tcaggctcacctgacgg agaaaaat catcctttgt aggtctgaaa aacgtgtctg aatcctgatg gtgggtctt tttcatttc caccccctca cagcacactc agggccatga agaggccatg gcctgtacag ccacggattt gggtgttgtt agacacagaa gggtgtgtag caaagtgagc cccacgcatg cgtagactct tccctcggct tctgctctcc atggaaacac aactgatcac atcatgattg atcacggtag ccctctggaa tggggaagcg gctgcgccct ggacggagag gggcggggac ttcgcgactg caggcggagg gagggcgggt gtcgctggcg caggcggtga cagggagaca ccgccgccac tgagtattcc tatgcaagtt tcttcatctt cctgtgcatt atttgatggg gccatggaag gaacgggaagg aacggcgtcc tggcccgctc ggggcccgcg cacgccgcca ccaagccgcg ggggcgggtc ggaggggaga gttgcgtcag ccaggccgct gtcagatgac gagcccgggg cgtgacgggg tggagcatcc ccaaaaaagt gcatgcctag gatcccgccc agtgtatccc tgcgcgcggc gggccgggct gggcagcttt ataaacagcc gtggtgtgag cctcgaaggg aaccatcagc gcctcctgtc cacggagctc caggtctaca atctcgagcc accatggtga gcaagggcgaggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag taagctagca cccagctttc ttgtacaaag tggttgatgg gtcaccatct agatggccat atgatcgata cgtactagtc tcgacggtac ctttaagacc aatgacttac aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaaa tcgtcgagag atgctgcata taagcagctg ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagacccttttagtcagtg tggaaaatct ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa tatcagagag tgagaggcct tgacattata atagatttag caggaattga actaggatag gagcacacag gcaaagctgcca aggattaccca agattaag tgcacatacc tggctaatcc cagatcctaa ggattacatt aagtttacta accattatat aatgatttat agtttaaagt ataacttat ctaatttact attctgacag atattatta atcctcaat atcatagag atgattacta ttatccccat ttaacacaag aggaattag tg gaggcagataaga tccgttagtt acgactctat gatcttga cacaattcc atttactcct caccctatga ctcagtcgaa tatatcaag ttatggacat tatgctaagt aacaaattac ccttttatat agtaact gagtagattg agagagaaa tgtttgcaa acctgaataga ctagattagatag aggattagtagaag gttttaacaa gtaacttggt tagaaaggga ttcaatgca taaagcaagg gataaatttt tctggcaaca agactataca attackacctt aaatatgact tcaatatt gttggaactt gataaacta attaatatt attgaagatt atcaatatta taaatgtaat ttacttta aaagggaaca tagatacattaacagt tcacaatttg tcaaacaag ttgttatta acacaagtagaatactgcat tcaattaagt tgactgcaga ttttgtgttt tgttaaaatt agaaagagat aacaacaatt tgaattattg aaagtaacat gtaaatagtt ctacatacgt tcttttgaca tcttgttcaa tcattgatcg aagttcttta tcttggaaga atttgttcca aagactctga aataaggaaa acaatctatt atatagtctc acacctttgt tttactttta gtgatttcaa tttaataatg taaatggtta aaatttattc ttctctgaga tcatttcaca ttgcagatag aaaacctgag actggggtaa tttttattaa aatctaattt aatctcagaa acacatcttt attctaacat caatttttcc agtttgatat tatcatataa agtcagcctt cctcatctgc aggttccaca acaaaaatcc aaccaactgt ggatcaaaaa tattgggaaa aaattaaaaa tagcaataca acaataaaaa aatacaaatc agaaaaacag cacagtataa caactttatt tagcatttac aatctattag gtattataag taatctagcc agatcctcta cgccggacgc atcgtggccg gcatcaccgg cgccacaggt gcggttgctg gcgcctatat cgccgacatc accgatgggg aagatcgggc tcgccacttc gggctcatga gcgcttgttt cggcgtgggt atggtggcag gccccgtggc cgggggactg ttgggcgcca tctccttgca tgcaccattc cttgcggcgg cggtgctcaa cggcctcaac ctactactgg gctgcttcct aatgcaggag tcgcataagg gagagcgtcg aatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccagccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactattaactggcga actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagca ttgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcagggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggcctttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgagga gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggcttttt ggaggcctag gcttttgcaa aaagcttgga cacaagacag gcttgcgaga tatgtttgag aataccactt tatcccgcgt cagggagagg cagtgcgtaa aaagacgcgg actcatgtga aatactggtt tttagtgcgc cagatctcta taatctcgcg caacctattt tcccctcgaa cactttttaa gccgtagata aacaggctgg gacacttcac atgagcgaaaaatacatcgt cacctgggac atgttgcaga tccatgcacg taaactcgca agccgactga tgccttctga acaatggaaa ggcattattg ccgtaagccg tggcggtctg taccgggtgc gttactggcg cgtgaactgg gtattcgtca tgtcgatacc gtttgtatt ccagctacga tcacgacaac cagcgcgagc ttaaagtgct gaaacgcgca gaaggcgatg gcgaaggctt catcgttatt gatgacctgg tggataccgg tggtactgcg gttgcgattc gtgaaatgta tccaaaagcg cactttgtca ccatcttcgc aaaaccggct ggtcgtccgc tggttgatga ctatgttgtt gatatcccgc aagatacctg gattgaacag ccgtgggata tgggcgtcgt attcgtccg ccaatctccg gtcgctaatc ttttcaacgc ctggcactgc cgggcgttgt tctttttaac ttcaggcggg ttacaatagt ttccagtaag tattctggag gctgcatcca tgacacaggc aaacctgagc gaaaccctgt tcaaaccccg ctttaaacat cctgaaacct cgacgctagt ccgccgcttt aatcacggcg cacaaccgcc tgtgcagtcg gcccttgatg gtaaaaccat ccctcactgg tatcgcatga ttaaccgtct gatgtggatc tggcgcggca ttgacccacg cgaaatcctc gacgtccagg cacgtattgt gatgagcgat gccgaacgta ccgacgatga tttatacgat acggtgattg gctaccgtgg cggcaactgg atttatgagt gggccccgga tctttgtgaa ggaaccttac ttctgtggtg tgacataatt ggacaacta cctagagatttaaagctc taaggtaat aaaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag attccaacct atggaactga tgaatgggag cagtggtgga atgcctttta tgaggaaac ctgttttgct cagagaactcaat gatcagatgaggctgct tctactccctc caaaaagaa gagaaaggta gaagacccca aggactttcc tcagaattg ctaagtttt tgagtcatgc tgtgtttagt atagaactc tgcttgctt tgctatac accacaaagg aaaaagctgc actgctatac tgaaaggtag agaaaaaaaaactc ggcataacag ttataatcat aacatactgt tttcttac tccacacagg catagagtgt ctgctatta taactatgct CAaaattgt gtacctttag ctttaatt tgtaaagggg ttataagga atatttgatg tatagtgcct tgactagat tcatagaggcatcatagaggcaatca tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatg ttacaata agcaatagca tcacaatt cacaataa gcattttt gcactcattc tagttgtgt tcatcattacaatt atcttcatcatact actgatac tcaagctac caaatcatc ccaaacttcc cacccatac cctattacca ctgccaatta cctagtggtt tcattactc taaacctgtg attcctct 3-30 Sequences 3-30-1 Sequence Number [ID] 30 3-30-2 Molécule Type DNA 3-30-3 Lenqth 10867 3-30-4-1 Features Location / Qualifiers source 1..10867 mol_type= other DNA organism= synthetic construct NonEnglishQualifier Value 3-30-5 Residues acaaggctac ttccctgatt agcagaacta cacaccaggg ccaggggtca gatatccact taaaggagag aacaccagct tgttacaccc tgtgagcctg catgggatgg atgacccgga gagagaagtg ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga tggggacttt ccagggaggc gtggcctggg cgggactggg gagtggcgag ccctcagatc cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtggcgc ccgaacaggg acttgaaagc gaaagggaaa ccagaggagc tctctcgacg caggactcgg cttgctgaag cgcgcacggc ggagagagat gggtgcgaga gcgtcagtat taagcggggg- agaaafiagat cgcgatggga aaaaattcgg ttaggccag gggaaagaa aaaatataa ttaaaacata taglatggc aagcagggag ctagaacgat tcgcagttaa tcgattaggacca ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc allalalaal acaglagcaa ccclclallg Lglgcalcaa aggalagaga laaagacac caggaagct ttagagaga gcaaacaaa agtaagacca ccgcacagca agcgggattaccctgaggagagagagagagagatto tataaata taaagtagta aaaattgaac cattaggagt agcaccacc aaggcaag gagagtggt gcagagagaa aaaagagcag tgggaatagg- agcKtgtto ct^ggttot tgggagcagc aggaagcact atggcgcag cgtcaatgattacattagggctgacggta cagcagcaga acaatttgct gagggctatt gaggcgcaac agcatctgtt gcaactcaca gtetggggea tcaagggegat ccaggcaaga atcc^gctg tggaagata cctaaggat caacagctcc tggtggattg gggtgtgct ggaaaactca tgtggatgcaccacta taaatatctg gaacagattt ggaatcacac gacctggatg gagtgggaca gagaattta cattacaca agcttaac actccttaattgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat tagataatg ggcaagttg tggaattggt ttacatac aaattggctg tgtatataa ccccgagggg acccgacagg cccgaaggag agggagaga aggtggagag agagacagag acagatccatcgattagtg aacggatcte gacggtacg ccgaatteac aaatggcagt atcatccac aattttaaaa gaaaggggg gattggaggcata agcaggagtagatagcagca taaagaatta caaaaaacaaa ttacaaaat tcaaaatttt cgggtttatt acagggacag cagagatcca ctttggctga tacgcggatc taaggtgtcc cagaccccaa gctaggaatg gggagggaaa tggaggaatc ccaaatgcct |||||||^|| gcggctgagg gcggggacag gggtgcggcg gacccactgc tcccattacc cgaccagcgc ctccctctcct ccttggatgg gtgccctgt: cttgcteaga actgcctgtt tacacaactg aacatccggg agagccggtc cgtttctcag gcagactagg ccattaggtg cctcggagaa aggacccaag gctgctccgt ccttcacaga cacagtccaccg cctacctfcga gaacaagggtcc ttcgagtacccg aaccaggcfc tctcgcaccg cccagagcgg gccctcctg tcattacct actgaagggc gcaccctgcc ctctgattgg tccaaggaag gctggggggc aggacgggag gcgaaacccc tggaatattc ccgacctggc agcctcatcg agcttggtga ttggctcaga aggggaaagg cgggtctcca cgacgactta taaaagccga ggggcgcgcg gtccggaaaa cggccagcct gaggagctgc tgcgagggtc cgcttcgtct ttcgagagtg actcccgcgg tcccaaggct ttccagagcg aacctgtgcg gctgcaggca ccggcgtgtt gagtttccgg cgttccgaag gactgagctc ttgtcgcgga tcccgtccgc cgtttccagc ccccagtctc agagcggagc ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtecggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg actteaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga ggttgatggg tcaccatcta gatggccata tgatcgatac gtactagtct cgacggtacc tttaagacca atgacttaca aggcagctgt agatettagc cactttttaa aagaaaaggg ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt taacttgcaat agaatgaat atagagagt gagaggcctt gatacatta tagatKagc aggaattgaa ctaggagtgg agcacacagg caaagctgca gaagtacttg gagaagcca ccagagatac tcacgattct gcacatacct ggctaatacc agatcctaag gattacatta taacacaaga ggaaactgag agggaagat gttgaagtaa tttcccacà attacks agaaagggat fcaatgcat aaagcaaggg âtaaatttÉt ctggcaacaa gactataca atcattagag taggaaacaa tccttattat cacàatttgt caàacàagt ttgttattaa tgcagataga aaacctgaga ctggggtaat ttttattaaa atctaattta atctcagaaa ctcatctgca ggttccacaa CAAAATcca accaactgtg gatcaaaaat attgggaaaa gccggacgca tcgtggccgg catcaccggc gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct cgccacKcg ggctoatgag cgGSgfito ggcgtgggta tggtggcagg ccccgtggcc gggggactgt tggggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg g^cacgagt gggttaçatc gaaçtggatc fcaaçagçgg taagateçtt gagagttttç gççççgaaga acgtttteca atgaigagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcat tgagaaagcg ccacgcttec cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta totttatagt cctgtegggt ttegccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg cctftÈgcte acatgttett cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tcccgcgcg ttggccgatt catteatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggccccag caggcagcagc atgcatcag attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga tttattatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggctttttttg gaggcctagg cttttgcaaa aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc agggagaggc agtgcgcgcgcgcgcgcgc ttagtgcgcc agatctataf aatetagcgc aacctatttt atacatcgtc acctgggaca tgttgcagat ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattatfgc cgtaagccgt ggcggtetgt accgggtgcg ||||||||||||||||||^^^^ cacgacaacc agcgcgagct taaagtgctg aaacgcgcag aaggcgatgg cgaaggcttc ccaaaagcgc actttgtcac catcttcgca aaaccggctg gtcgtccgct ggttgatgac taigtigtig atatcccgca agatacctgg attgaacage cgtggggatat gggcgtcgta taaaaccatc cctcactggt atcgcatgat taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact tctgtggtgt gacataattg gacaaactac agtggtggaa tgcctttaat gaggaaaacc tgttttgctc agaagaaatg ccatctagtg atagaactct tgcttgcttt gctatttaca ccacaaagga aaaagctgca ctgctataca ttaaaaaacc tcccacacct ccccctgaac ctgaaaacaþActtcattc tctggatcaa ctggataact caagctaacc aaaatcatcc caaacttccc 3-31 IIUUIUI Sequences iiilill Sequence Number [ID] 3-31-2 Molecule Type DNA 3-31*3 3-31-4-1 Features Location / Qualifiers source 80.

80. DNA molecules. synthetic construct NonEnglishQualifier Value 3-31-5 Residues gaattatttt cattttaaag aaattgtatt tgttaaatat gtactacaaa cttagtagtt ggaagggcta attcactccc aaagaagaca agatatccta gatctgtgga tctaccacac acaaggct agccct cacac ccaggggtca gatatccact gacctttgga tggtgctaca agctagtacc agttgagcca gataaggtag aagaggccaa taaaggagag aacaccagct tgttacaccc tgtgagcctg catgggatgg atgacccgga gagaagtg ttagagtgga ggtttgacag ccgcctagca ttcctcc gagtacttca agaactgctg atatcgagct tgctacaagg gactttccgc tggggacttt ccagggaggc gtggcctggg cgggactggggagtggcgag ccctcagatc ctgcatataa gcagctgctt ttgcctgta ctgggtctct ctggttagac cagatctgag cctgggagct ctctgctaa ctagggacc cactgctta gcctcataa agctgcctt gagtgcttca agtagtgctgtgtgtgtgtgt tggtaactag agatccctca gaccttag gtcagtgtgg aaatctcta gcagtggcgc ccgaacaggg acttgaagc gaaagggaaa ccagaggagc tctcgacg caggactcgg cttgctgaag cgcgcacggc agagggacgac tggcagcgac gggcaggc ttgactagcg gaggctagaa ggagagagat gggtgcgaga gcgtcagtat taagcgggg agaattagat cgcgatggga aaaaattcgg ttaaaacata tagtagggc aagcagggag ctgaggacttag tcctcattag tcgt cagaaggctg tagacaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatatat acagtagcaacctattg tgtgcatca aggataga taaagacac caaggaagct ttagacaga taggaggat gcaaaaaa agtagcagcagca cc gagatatgag ggacaatttgg agaagtgaat tataaata taaagtagta aaaattgaac cattaggagt agcaccacc aaggcaaga gagagtggt gcagagagaa aaagagcag tgggaatagg agctttgttccttgggttct tgggagcagc aggaagcagct atgggcgcag cgtcaatgac gctgacggta caggccagac aattattgtc tggtatagtg cagcagcaga acatttgct gaggctatt gaggcgcac atcatctt gcaactcaca gggcagcagggccc tggaaagata cctaaaggat cacagctcc tgggatttg gggttgctct ggaaaactca ttgcaccac tgctgtgcct tggaatgcta gttggagta taaatctg gacagattt ggaatcacac gacctggatg gagtgggaca gagagaatctta caatacaca caaaaccagc aagaaaagaa tgaacagaa ttattggaat tagataatg ggcaagtttg tggaattggt ttacatac aaattggctg tgtataata attattcat aatgatagta ggaggctgg taggtttag gatagtttt catagtactt ctatagcaccacattagggacctaggtagt ccccgagggg acccgacagg cccgaaggag taggagaga aggtggagag aggacagag acagatccatcgattagtg aacggatcc gacggtacg ccgaattcac aaatggcagt atcatccac aattttaaaa gaaaggggg gattggcaggcata tacagagagcagcagca taaagaatta caaaaaaaaaaaaaat tcaaatttt cgggttttatt acagggacag cagagatcca ctttggctga tacgcggatctagtgaggcc tgcaagctcc gggcgcctgg cctacctaac tcagccccgc agtctctgca gaaccccctg cagccccgtg gcccagtttc tccatttgct cacaatggcc aacggcgtga ggcacttgag cggaatgcgg acggtgcctc cgacagcttt cccgcagtgc atgatctcag gaggggcccc agagacggaa gtttacgacg cccagagcgc tccttctgga cgtgccctgg actcgacttg ggactgagtc tgtgccgcct aggctggcag ggactcggcc agatgcacta gcggcaaggc tgggctgaca ccgcctggga ctcgctcgcc gtacctccaa ggggcccagg tcatgagggg gcggctgggg agacgcccgc ccggtgcccg ccctgggccc ggcgggtgcc ccctgcccgc cgcctgacgc aatccgaggc gccttgctg catgccggcg ctggagaac ctccctgcc gttgcatcac tcctgccagg tttgccag aggtggagct gaaccatca gcggcgcgc tggcggacgagtta gccgaccgagcg ttgattggcc aaaaggggat tgccccacc ccaatcaccg cggcagctgg ccgcggtggg cgtgtcc cggcaagaag gtttaaaggg cgcctccatg gggggcgctc agctggagct accgagcggt gccaggccag gtgtgtgcggtt acccgcgt cccgct ccagccccgg aggccgcctg ggctcctcc tgtgccaggc accattcgag ccaccatggt ggcaagggc gaggagctt tcaccgggt ggtgcccatc ctggtcgagc tggacggg cgtaacggaggcc gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc caccaccgt cagccgctc cccgaccaca tgagcagca cgactcttc aagtccgcca tgcccgaccaccag ctacc ggacgacggc actacaaga cccgcgccga ggtgaagttc gaggcgaca ccctggtga ccgcatcgag ctgaagggca tcgacttca ggaggacggc aacatcctgg ggcacaagct ggagtacac tacacagcc acaccagtggcct accacgagccta ttcagatccgccacacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg cccgtgctg ctgcccgac accactacct gagcacccag tccgctga gcaaagaccc caacgagaag cgcgatcaca tgccgactcgct ggatcactct cggcatggac gagctgtaca agtaagctag cacccagctt tctgtacaa agtggttgat gggtcaccat ctagatggcc atatgatcga tacgtactag tctcgacggt acctttaaga ccaatgactt acaggcagc tgtagatctt agggacgacttag tagaggacttag acgaagacaa aatcgtcgag agatgctgca tataagcagc tgctttgc tgtactggg tctctctggt tagaccagat ctgagcctgg gagctctg gctaactagg gaacccactg cttaagccctc ataaagctt gccttgagtg cttcaagtgctt tggtg tggtg actagagatc cctcagaccc tttagtcag tgtggaaaat cttagcagt agtagttcat gtcatcttat tattcagtat ttataacttg haaagaatg atatcagag agtgagaggc cttgacatta taatagatt agcaggaatt gaactaggag tggatagcaccag tgcagcaccag agggaag agggag tactcacgat tctgcacata cctggctaat cccagatcct aaggattaca ttaagtttac taacatttat ataatgattt atagtttaaa gtataaactt atctaattta ctattctgacagatattaat taatcctca attacatag agatgattac tattatcccc atttacaca agaggaact gagagggaaa gatgttgaag taatttccc acaattacag catcgttag tacgactct gactcattact acattagtagtagtcg acccttttat atagtaaata ctgagtagat tgagagaga aattgttgc aaacctgaat agcttcaaga agagagaag tgaggataag ataacagtt gtcatttaac aagttttaac aagtaactg gttagaagg gattcaatg cataagca gggataatt ttcatatactatagtataggatt tcaataggcaaccga ttgataaaac taattaata tattacaat tataaatgta atttactttt aaaaagggaa catagaaatg tgtacatta gagtagaaaa caatccttat taacacaagt agaatactgc attcaattgattagttgattagacaga atacaacaa tttgaattat tgaaagtaac atgtaatag ttctacatac gttctttga catcttgttc atcattgat cgaagttctt tatctggaa gatttgttc caaagactt gaaatagga aaacaatcta ttatatagtc tcacaccttt gtttactatt tagttattagat tcttctctga gatcattca cattgcagat agaaaacctgagactggggt aatttttatt aaaatctaat ttaatctcag aaacacatct ttattctaac atcaattttt ccagtttgat aattcatat aaagtcagcc ttcctcatct gcaggttcca caacaaaaat ccaaccaact gtggatcaaa aatattggga aaaaattaaa aatagcaata caacaataaa aaaatacaaa tcagaaaaac agcacagtat aacaacttta tttagcattt acaatctatt aggtatctag ccagatcctc tacgccggac gcatcgtggc cggcatcacc ggcgccacag gtgcggttgc tggcgcctat atcgccgaca tcaccgatgg ggaagatcgg gctcgccact tcgggctcat gagcgcttgt ttcggcgtgg gtatggtggc aggccccgtg gccgggggac tgttgggcgc catctccttg catgcaccat tccttgcggc ggcggtgctc aacggcctca acctactact gggctgcttc ctaatgcagg agtcgcataa gggagagcgt cgaatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta tagttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaatgcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactcatatatacttt

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