Liposomal composition and methods for the production and use thereof
A liposome composition with a specific phospholipid coating and low humidity formulation addresses the complexity and toxicity issues of existing methods, achieving stable and bioavailable bioactive substances that form liposomes upon hydration.
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- NL CONDINANT LTD
- Filing Date
- 2026-06-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for producing liposome compositions are complex, require the use of toxic organic solvents, are difficult to scale up, and compromise the physical, chemical, and biological properties of the liposomes, leading to instability and low bioavailability of bioactive substances.
A liposome composition comprising powdered bioactive substances, phospholipids, and a protective agent, with a phospholipid coating thickness of 5-20% of the particle size and a relative humidity of 10% or less, prepared by spraying a phospholipid emulsion and a protective agent solution onto fluidized powder particles, followed by drying.
The method improves the stability and bioavailability of bioactive substances by ensuring uniform phospholipid and protective agent distribution, protecting the liposomes from environmental and mechanical damage, and allowing them to spontaneously form upon hydration, enhancing their commercial potential.