Pharmaceutical composition

Abstract

To provide a compound for treating and preventing diseases and conditions including heart failure, heart failure with a maintained ejection fraction, heart failure with a mildly reduced ejection fraction, heart failure with a reduced ejection fraction, chronic kidney disease, and acute kidney injury.SOLUTION: The present invention provides a compound represented by formula (I) or its pharmaceutically acceptable salt. Such a compound is RXFP1 modulator and is useful as a treatment agent.SELECTED DRAWING: None

Description

[Technical Field]

[0001] Described herein are compounds (including salts thereof) that are modulators of RXFP1, uses of such compounds, compositions containing such compounds, intermediates useful in the methods for making such compounds, and methods for making such compounds using such intermediates. [Background technology]

[0002] background Relaxin is a pleiotropic hormone known to mediate systemic hemodynamic and renal adaptive changes during pregnancy. Relaxin has also been shown to have antifibrotic properties and beneficial effects in heart failure, such as those associated with acute decompensated heart failure (ADHF). Heart failure is associated with significant morbidity and mortality. Heart failure is characterized by increased myocardial cell death and complex tissue remodeling, including interstitial fibrosis. Relaxin activates many signaling cascades that have been shown to be beneficial in the setting of ischemia-reperfusion and heart failure. These signaling pathways include activation of the phosphoinositide 3-kinase pathway and the nitric oxide signaling pathway (Bathgate RA et al. (2013) Physiol. Rev. 93(1): 405-480; Mentz RJ et al. (2013) Am. Heart J. 165(2): 193-199; Tietjens J et al. (2016) Heart 102: 95-99; Wilson SS et al. (2015) Pharmacology 35: 315-327).

[0003] Clinical trials using serelaxin, an unmodified recombinant human relaxin-2, are underway. Continuous intravenous administration of serelaxin to hospitalized patients improved markers of cardiac, renal, and hepatic injury and congestion (Felker GM et al. (2014) J. Am. Coll. Cardiol. 64(15): 1591-1598; Metra M et al. (2013) J. Am. Coll. Cardiol. 61(2): 196-206; Teerlink JR et al. (2013) Lancet 381(9860): 29-39). However, rapid clearance of serelaxin from the patient's circulation limited its therapeutic efficacy, and positive effects rapidly disappeared when intravenous infusion was discontinued. Furthermore, approximately one-third of patients experienced a significant drop in blood pressure (>40 mmHg) after intravenous administration of serelaxin, resulting in the dose having to be reduced by half or more.

[0004] The cognate receptor for human relaxin is RXFP1, a well-validated and pharmacologically important GPCR family 1c member whose activation by the hormone relaxin is associated with hemodynamic, anti-fibrotic, and anti-inflammatory properties (Halls ML et al., (2015), Pharmacol Rev. 67(2): 389-440).

[0005] Small molecule modulators of RXFP1 are sought as relaxin mimetics. For example, WO 2013 / 165606A1 (Marugan, JJ, et al.,); Xiao J et al. (2013) Nat. Commun. 4:1953 and McBride A et al. (2017) Scientific Reports 7:10806 discuss small molecule modulators of RXFP1. Summary of the Invention

[0006] Despite the above, there remains a need for additional compounds that are modulators of RXFP1 and can produce compounds that are particularly promising for development as therapeutic agents.Compared to other known RXFP1 modulators, the compounds of the present invention can also exhibit improved modulation of RXFP1.Compared to other known RXFP1 modulators, the compounds of the present invention can also exhibit favorable pharmacokinetic profiles (e.g., lower intrinsic clearance) and / or advantageous physical properties (e.g., higher aqueous solubility).Therefore, such compounds can be particularly useful for treating disease conditions in which modulation of RXFP1 is beneficial.

[0007] Summary of the Invention Briefly, herein, in part, there is provided a compound of formula (I): [ka] [In the formula, A is, [ka] and Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, or a 4- to 10-membered cycloalkenyl; R 7 is selected from -H, -F, -CH3 and -OCH3; Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl; C 1-4 Alkoxy; -OH; -F and -COO(C 1-4 alkyl), p is 0, 1 or 2; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 4- to 10-membered cycloalkenyl, or a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; Each R 9 is C 1-4 Alkyl, C 1-4 independently selected from alkoxy, -halo, and -OH; q is 0, 1 or 2; R 1 are -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -C(NH)NH2, -SO2NH2, -NHSO2Me, [ka] is selected from X is selected from a bond, —CH—, —O—, —S—, —CHO—, and —OCH—; Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 2-6 Alkylene; unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 Cycloalkylene; unsubstituted or 1-2 R 14 C substituted by a substituent 5-8 Cycloalkenylene; having 1 to 3 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 2 R 14 5-8 membered heterocycloalkylene substituted by a substituent; unsubstituted or 1-2 R 14 phenylene substituted by a substituent; phenylene having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and unsubstituted or having 1 to 2 R 14 5- or 6-membered heteroarylene substituted by substituents; and [ka] is selected from R14 is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; 1-3 Alkyl; C unsubstituted or substituted with 1 to 3 -F substituents 1-3 alkoxy; cyclopropyl which is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2; Z is a bond; C which is unsubstituted or substituted by 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 1-3 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted with 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 2-4 Heteroalkylene; C 3-4 selected from cycloalkylene and -CH=CH-; R 5 is selected from -H, -Me and -F; R 6 is -(CR 10 R 11 ) n R 12 and n is 0, 1 or 2; R 10 and R 11 are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl, R 12 is unsubstituted or -OH, -F, -CN and C 1-4 C substituted by 1 to 5 substituents selected from alkoxy 3-8 Alkyl; unsubstituted or 1 to 4 R 13 C substituted by a substituent 3-10 Cycloalkyl; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 4 R 135-10 membered heterocycloalkyl substituted by substituents; unsubstituted or -halo, unsubstituted or substituted by 1-3 -F substituents 1-4 Alkyl, C 3-5 phenyl substituted by 1 to 3 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and -SO2CF3; 6-membered heteroaryl having 1 to 2 nitrogen heteroatoms and substituted by 1 to 3 substituents selected from -halo, -SF5, -CF3, -OCF3 and -SO2CF3; [ka] is selected from Each R 13 is -OH; -F; -CN; C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 Alkoxy and C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 independently selected from alkyl, U, V, and W are each independently selected from C and N, provided that when U is N, R 2 is absent and V is N, then R 3 does not exist and W is N, then R 4 is a condition that does not exist, where: (i)R 2 , R 3 and R 4 are each independently -C, unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe; 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me3-4 cycloalkoxy; or (ii) U and V are each C; R 2 and R 3 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; R 4 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy; or (iii) V and W are each C; R 3 and R 4 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; R 2 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy] A pharmaceutical composition comprising a compound of the formula: or a pharmaceutically acceptable salt thereof is described.

[0008] Also described herein, in part, is a pharmaceutical composition that includes a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

[0009] Also described herein, in part, are pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in therapy.

[0010] Also described herein, in part, is a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for use in treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury.

[0011] Also described herein, in part, is the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury.

[0012] Also described herein, in part, is a method for treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury in a subject in need of such treatment, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

[0013] Also described in part herein are intermediate compounds (described herein) or salts thereof.

[0014] Also described herein, in part, are processes for preparing compounds of formula (I) or pharmaceutically acceptable salts thereof using intermediate compounds (described herein) or salts thereof.

[0015] Further aspects of Applicant's invention will become apparent to those skilled in the art upon reading this specification.

[0016] Description of Exemplary Embodiments Many embodiments are detailed throughout this specification and will become apparent to those skilled in the art, and this specification should not be construed as being limited to any particular embodiment described herein.

[0017] In an embodiment, a compound of formula (I): [ka] [In the formula, A is, [ka] and Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, or a 4- to 10-membered cycloalkenyl; R 7 is selected from -H, -F, -CH3 and -OCH3; Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl; C 1-4 Alkoxy; -OH; -F and -COO(C 1-4 alkyl), p is 0, 1 or 2; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 4- to 10-membered cycloalkenyl, or a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; Each R 9 is C 1-4 Alkyl, C 1-4 independently selected from alkoxy, -halo, and -OH; q is 0, 1 or 2; R 1 are -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -C(NH)NH2, -SO2NH2, -NHSO2Me, [ka] is selected from X is selected from a bond, —CH—, —O—, —S—, —CHO—, and —OCH—; Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 2-6 Alkylene; unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 Cycloalkylene; unsubstituted or 1-2 R 14 C substituted by a substituent 5-8 Cycloalkenylene; having 1 to 3 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 2 R 14 5-8 membered heterocycloalkylene substituted by a substituent; unsubstituted or 1-2 R 14 phenylene substituted by a substituent; phenylene having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and unsubstituted or having 1 to 2 R 14 5- or 6-membered heteroarylene substituted by substituents; and [ka] is selected from R14 is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; 1-3 Alkyl; C unsubstituted or substituted with 1 to 3 -F substituents 1-3 alkoxy; cyclopropyl which is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2; Z is a bond; C which is unsubstituted or substituted by 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 1-3 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted with 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 2-4 Heteroalkylene; C 3-4 selected from cycloalkylene and -CH=CH-; R 5 is selected from -H, -Me and -F; R 6 is -(CR 10 R 11 ) n R 12 and n is 0, 1 or 2; R 10 and R 11 are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl, R 12 is unsubstituted or -OH, -F, -CN and C 1-4 C substituted by 1 to 5 substituents selected from alkoxy 3-8 Alkyl; unsubstituted or 1 to 4 R 13 C substituted by a substituent 3-10 Cycloalkyl; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 4 R 135-10 membered heterocycloalkyl substituted by substituents; unsubstituted or -halo, unsubstituted or substituted by 1-3 -F substituents 1-4 Alkyl, C 3-5 phenyl substituted by 1 to 3 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and -SO2CF3; 6-membered heteroaryl having 1 to 2 nitrogen heteroatoms and substituted by 1 to 3 substituents selected from -halo, -SF5, -CF3, -OCF3 and -SO2CF3; [ka] is selected from Each R 13 is -OH; -F; -CN; C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 Alkoxy and C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 independently selected from alkyl, U, V, and W are each independently selected from C and N, provided that when U is N, R 2 is absent and V is N, then R 3 does not exist and W is N, then R 4 is a condition that does not exist, where: (i)R 2 , R 3 and R 4 are each independently -C, unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe; 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me3-4 cycloalkoxy; or (ii) U and V are each C; R 2 and R 3 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; R 4 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy; or (iii) V and W are each C; R 3 and R 4 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; R 2 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy] or a pharmaceutically acceptable salt thereof.

[0018] Part A, Ring B, Ring C, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , n, p, q, r, U, V, W, X, Y, and Z, alone or in combination, may be applied to the description of compounds of Formula (I) provided herein.

[0019] A is, [ka] is.

[0020] A is, [ka] is.

[0021] A is, [ka] is.

[0022] A is, [ka] is selected from.

[0023] A is, [ka] is selected from.

[0024] A is, [ka] is selected from.

[0025] A is, [ka] is.

[0026] A is, [ka] is selected from.

[0027] A is, [ka] is.

[0028] A is, [ka] is.

[0029] A is, [ka] is.

[0030] A is, [ka] is.

[0031] A is, [ka] is.

[0032] A is, [ka] is.

[0033] A is, [ka] is.

[0034] A is, [ka] is.

[0035] Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, or a 4- to 10-membered cycloalkenyl.

[0036] Ring B is C 1-3 monocyclic 5- to 7-membered cycloalkyl optionally bridged by alkylene; having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, C 1-3 monocyclic 5- to 7-membered heterocycloalkyl optionally bridged by alkylene; having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, C 1-3 Monocyclic 5- to 7-membered heterocycloalkenyl optionally bridged by alkylene or C 1-3 It is a monocyclic 5- to 7-membered cycloalkenyl optionally bridged by alkylene.

[0037] Ring B is a 4- to 10-membered cycloalkyl or a 4- to 10-membered cycloalkenyl.

[0038] Ring B is a 5- to 8-membered cycloalkyl or a 5- to 8-membered cycloalkenyl.

[0039] Ring B is C 1-3 Monocyclic 5- to 7-membered cycloalkyl optionally bridged by alkylene or C 1-3 It is a monocyclic 5- to 7-membered cycloalkenyl optionally bridged by alkylene.

[0040] Ring B is C 1-2 Cyclohexyl or C optionally bridged by alkylene 1-2 It is a cyclohexenyl optionally bridged by an alkylene.

[0041] Ring B is C 1-2 1,4-bridged cyclohexyl or C 1-2 It is a cyclohexenyl 1,4-bridged by alkylene.

[0042] Ring B is bicyclo[2.2.1]heptanyl or bicyclo[2.2.1]hept-2-enyl.

[0043] Ring B is bicyclo[2.2.1]heptanyl.

[0044] R 7 is selected from —H, —F, —CH 3 and —OCH 3 .

[0045] R 7 is selected from -H and -F.

[0046] R 7 is -H.

[0047] Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl; C 1-4 Alkoxy; -OH; -F and -COO(C 1-4alkyl).

[0048] Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-2 Alkyl; C 1-2 Alkoxy; independently selected from -OH and -F.

[0049] Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-2 is independently selected from alkyl and -F.

[0050] Each R 8 is independently selected from -Me and -F.

[0051] p is 0, 1 or 2.

[0052] p is 0 or 1.

[0053] p is 0.

[0054] Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 4- to 10-membered cycloalkenyl, or a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen.

[0055] Ring C is a phenyl; a monocyclic 5- or 6-membered heteroaryl having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur; C 1-3 monocyclic 4- to 7-membered cycloalkenyl optionally bridged by alkylene or having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, 1-3 It is a monocyclic 4- to 7-membered heterocycloalkenyl optionally bridged by alkylene.

[0056] Ring C is C 1-2monocyclic 5- to 7-membered cycloalkenyl optionally bridged by alkylene or one oxygen heteroatom, C 1-2 It is a monocyclic 5- to 7-membered heterocycloalkenyl optionally bridged by alkylene.

[0057] Ring C is a monocyclic or polycyclic 6- to 10-membered aryl.

[0058] Ring C is phenyl.

[0059] Ring C is not phenyl.

[0060] Each R 9 is C 1-4 Alkyl, C 1-4 Independently selected from alkoxy, -halo and -OH.

[0061] Each R 9 is C 1-2 Alkyl, C 1-2 Independently selected from alkoxy, -halo and -OH.

[0062] q is 0, 1 or 2.

[0063] q is 0 or 1.

[0064] q is 0.

[0065] R 1 are -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -C(NH)NH2, -SO2NH2, -NHSO2Me, [ka] is selected from.

[0066] R 1 is -COOH or a bioisostere of a carboxylic acid, such as tetrazolyl. Such bioisosteres of carboxylic acids will be apparent to those skilled in the art.

[0067] R 1 are -COOH, -CONH2, [ka] is selected from.

[0068] R 1 is -COOH.

[0069] X is selected from a bond, —CH 2 —, —O—, —S—, —CH 2 O—, and —OCH 2 —.

[0070] X is selected from a bond, —CH 2 —, —O—, —CH 2 O—, and —OCH 2 —.

[0071] X is selected from a bond, —CH 2 —, and —O—.

[0072] X is selected from —CH 2 — and —O—.

[0073] X is —O—.

[0074] Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 2-6 Alkylene; unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 Cycloalkylene; unsubstituted or 1-2 R 14 C substituted by a substituent 5-8 Cycloalkenylene; having 1 to 3 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 2 R 14 5-8 membered heterocycloalkylene substituted by a substituent; unsubstituted or 1-2 R 14 phenylene substituted by a substituent; phenylene having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and unsubstituted or having 1 to 2 R 14 5- or 6-membered heteroarylene substituted by substituents; and [ka] is selected from.

[0075] Y is unsubstituted or one R 14 C substituted by a substituent 2-6 Alkylene; unsubstituted or one R 14 C substituted by a substituent 3-8 Cycloalkylene; unsubstituted or one R 14 C substituted by a substituent 5-8 Cycloalkenylene; having 1 to 3 heteroatoms independently selected from oxygen and sulfur, unsubstituted or containing one R 14 5- to 8-membered heterocycloalkylene substituted by substituents; unsubstituted or one R 14 phenylene substituted by a substituent; phenylene having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and unsubstituted or having one R 14 5- or 6-membered heteroarylene substituted by substituents; and [ka] is selected from.

[0076] Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 2-4 Alkylene; unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 Cycloalkylene; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 2 R 14 It is selected from 5- to 8-membered heterocycloalkylene substituted by a substituent.

[0077] Y is unsubstituted or one R 14 C substituted by a substituent 2-4 Alkylene; unsubstituted or one R 14 C substituted by a substituent 3-8Cycloalkylene; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or containing one R 14 It is selected from 5- to 8-membered heterocycloalkylene substituted by a substituent.

[0078] Y is unsubstituted or one R 14 C substituted by a substituent 4-6 Cycloalkylene and one to two heteroatoms independently selected from oxygen and sulfur, unsubstituted or containing one R 14 The heterocycloalkylene is selected from 5- or 6-membered heterocycloalkylenes substituted by substituents.

[0079] Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 It is a cycloalkylene.

[0080] Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 4-6 It is a cycloalkylene.

[0081] Y is unsubstituted or one R 14 C substituted by a substituent 3-8 It is a cycloalkylene.

[0082] Y is unsubstituted or one R 14 C substituted by a substituent 4-6 It is a cycloalkylene.

[0083] Y is unsubstituted or 1 to 2 R 14 It is a cyclohexylene substituted by a substituent.

[0084] Y is unsubstituted or one R 14 It is a cyclohexylene substituted by a substituent.

[0085] Y is one R 14 It is a cyclohexylene substituted by a substituent.

[0086] Optionally, in any of the embodiments of Y described herein, the X and Z substituents are attached to Y such that, when there are sufficient ring or chain atoms in Y, the X and Z substituents are not in a geminal or vicinal configuration.

[0087] Y is [ka] is.

[0088] Y is [ka] is.

[0089] Y is [ka] is.

[0090] Y is [ka] is.

[0091] Y is [ka] is.

[0092] Y is [ka] is.

[0093] Y is [ka] is.

[0094] r is 1, 2 or 3.

[0095] r is 1 or 2.

[0096] r is 2.

[0097] R 14 is a C which is unsubstituted or substituted by one substituent selected from -OH, -OMe, -F and -CN; 1-3 Alkyl; C unsubstituted or substituted with one -F substituent 1-3 alkoxy; cyclopropyl which is unsubstituted or substituted with one substituent selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2.

[0098] R 14 is a C which is unsubstituted or substituted by one substituent selected from -OH, -OMe, -F and -CN; 1-2 Alkyl; C unsubstituted or substituted with one -F substituent 1-2 alkoxy; cyclopropyl which is unsubstituted or substituted with one substituent selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2.

[0099] R 14 is selected from -H, -Me, -Et, -F, -OH, ═O, -OMe, -OEt, -CF, -CHOH, -CHOMe, -CN, -CHCN, -NH, -NHMe, and -NMe.

[0100] R 14 is -H.

[0101] R 14 is not -H.

[0102] R 14 is -Me.

[0103] Z is a bond; C which is unsubstituted or substituted by 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 1-3 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted with 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 2-4 Heteroalkylene; C 3-4 It is selected from cycloalkylene and -CH=CH-.

[0104] Z is a bond; C, unsubstituted or substituted by one substituent selected from -Me, -NH, -NHMe, and -NMe. 1-2 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted by one substituent selected from -Me, -NH2, -NHMe and -NMe2 2-3 Heteroalkylene; C 3-4 It is selected from cycloalkylene and -CH=CH-.

[0105] Z is a bond, -CH2-, -CH2CH2-, -OCH2-, -CH2O-, -C(CH3)2O-, -CH2CH2O-, -CH2CH2CH2O-, -CH2NH-, -CH (NH2)-, -CH(NMe2)-, -CH2CH(NMe2)-, -CH(NMe2)CH2-, -CH2CH(NH2)-, -CH(NH2)CH2-, -CH=CH-, [ka] is selected from.

[0106] Z is selected from a bond, —CH 2 —, —CH 2 CH 2 —, and —CH 2 O—.

[0107] Z is a bond.

[0108] R 5 is selected from -H, -Me and -F.

[0109] R 5 is -H.

[0110] R 6 is -(CR 10 R 11 ) n R 12 is.

[0111] R 6 is -(CR 10 R 11 )R 12 is.

[0112] R 6 is -(CH2)R 12 is.

[0113] R 6 -R 12 is.

[0114] R 6 teeth, [ka] is selected from.

[0115] R 6 teeth, [ka] is selected from.

[0116] R 6 teeth, [ka] is.

[0117] n is 0, 1 or 2.

[0118] n is 0 or 1.

[0119] n is 0.

[0120] n is 1.

[0121] R 10 and R 11 are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl.

[0122] R 10 and R 11 are each independently selected from -H, -Me, and -F.

[0123] R 10 and R 11 are -H, respectively.

[0124] R 12 is unsubstituted or -OH, -F, -CN and C 1-4 C substituted by 1 to 5 substituents selected from alkoxy 3-8 Alkyl; unsubstituted or 1 to 4 R 13 C substituted by a substituent 3-10 Cycloalkyl; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 4 R 13 5-10 membered heterocycloalkyl substituted by substituents; unsubstituted or -halo, unsubstituted or substituted by 1-3 -F substituents 1-4 Alkyl, C 3-5 phenyl substituted by 1 to 3 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and -SO2CF3; 6-membered heteroaryl having 1 to 2 nitrogen heteroatoms and substituted by 1 to 3 substituents selected from -halo, -SF5, -CF3, -OCF3 and -SO2CF3; [ka] is selected from.

[0125] R 12 is unsubstituted or -OH, -F, -CN and C 1-4 C substituted by 1 to 3 substituents selected from alkoxy 3-8 Alkyl; unsubstituted or 1 to 3 R 13 C substituted by a substituent 3-10 cycloalkyl and 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or 1 to 3 R 13 The heterocycloalkyl is selected from 5- to 10-membered heterocycloalkyl substituted with a substituent.

[0126] R 12 is unsubstituted or -F, -CN and C 1-2 C substituted by 1 to 3 substituents selected from alkoxy 4-6 Alkyl; unsubstituted or 1 to 3 R 13 C substituted by a substituent 4-6 cycloalkyl and 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or 1 to 3 R 13 It is selected from 5- to 6-membered heterocycloalkyl substituted by substituents.

[0127] R 12 is unsubstituted or -F, -CN and C 1-2 C substituted by 1 to 2 substituents selected from alkoxy 4-6 Alkyl; unsubstituted or one R 13 C substituted by a substituent 4-6 cycloalkyl and 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or containing one R 13 It is selected from 5- to 6-membered heterocycloalkyl substituted by substituents.

[0128] R 12 is unsubstituted or substituted by 1 to 3 -F substituents 4-6 C unsubstituted or substituted by 1 to 3 substituents selected from alkyl and -F and -Me 4-6cycloalkyl.

[0129] R 12 is unsubstituted or substituted by 1 to 3 -F substituents 3-6 C unsubstituted or substituted by 1 to 3 substituents selected from alkyl and -F and -Me 3-6 cycloalkyl.

[0130] R 12 is unsubstituted or substituted by 1 to 3 -F substituents 3-6 C substituted with alkyl and -F or -Me 3-6 cycloalkyl.

[0131] R 12 is selected from tert-butyl which is unsubstituted or substituted with 1 to 3 -F substituents; cyclobutyl which is unsubstituted or substituted with 1 to 2 substituents selected from -F and -Me; and bicyclo[1.1.1]pentanyl which is unsubstituted or substituted with 1 to 2 substituents selected from -F and -Me.

[0132] R 12 is selected from tert-butyl which is unsubstituted or substituted with 1 to 3 -F substituents; cyclobutyl which is unsubstituted or substituted with 1 to 2 substituents selected from -F and -Me; and bicyclo[1.1.1]pentanyl which is unsubstituted or substituted with 1 to 2 substituents selected from -F and -Me.

[0133] R 12 is selected from tert-butyl which is unsubstituted or substituted with 1 to 3 -F substituents; cyclobutyl which is unsubstituted or substituted with 1 substituent selected from -F and -Me; and bicyclo[1.1.1]pentanyl which is unsubstituted or substituted with 1 to 2 substituents selected from -F and -Me.

[0134] R 12 teeth, [ka] is selected from.

[0135] R 12 teeth, [ka] is selected from.

[0136] R 12 teeth, [ka] is.

[0137] R 12 is unsubstituted or -halo, C unsubstituted or substituted with 1 to 3 -F substituents 1-4 Alkyl, C 3-5 phenyl substituted by 1 to 3 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and -SO2CF3; 6-membered heteroaryl having 1 to 2 nitrogen heteroatoms and substituted by 1 to 3 substituents selected from -halo, -SF5, -CF3, -OCF3 and -SO2CF3; [ka] is selected from.

[0138] R 12 is -halo, C unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl, C 3-5 and phenyl substituted by 1 to 2 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and -SO2CF3.

[0139] R 12 teeth, [ka] each unsubstituted or substituted with one substituent selected from -halo, -Me, -CF3, and -CN.

[0140] R 12 teeth, [ka] is selected from.

[0141] Each R 13 is -OH; -F; -CN; C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 Alkoxy and C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 alkyl.

[0142] Each R 13 is -F; -CN; C unsubstituted or substituted by one substituent selected from -F, -OMe and -OEt 1-2 Alkoxy and C unsubstituted or substituted by one substituent selected from -F, -OMe and -OEt 1-2 alkyl.

[0143] Each R 13 is -F;-CN;C 1-4 Alkoxy and C 1-4 alkyl.

[0144] Each R 13 is -F;C 1-2 Alkoxy and C 1-2 alkyl.

[0145] Each R 13 are independently selected from -F; -OMe and -Me.

[0146] Each R 13 is -F.

[0147] Each R 13 is -Me.

[0148] U, V, and W are each independently selected from C and N, provided that when U is N, R 2 is absent and V is N, then R 3 does not exist and W is N, then R 4 is a condition that does not exist.

[0149] U, V and W are each C.

[0150] R 2 , R 3 and R 4 are each independently -C, unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe; 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy.

[0151] R 2 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 Alkoxy and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 3-4 cycloalkyl.

[0152] R 2is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2 Alkoxy and C unsubstituted or substituted by one substituent selected from -F and -OMe 3-4 cycloalkyl.

[0153] R 2 is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2 It is selected from alkoxy and cyclopropyl.

[0154] R 2 is not -H.

[0155] R 2 is -CN or -F.

[0156] R 2 is -CN.

[0157] R 2 is -F.

[0158] R 3 is C, which is unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 Alkoxy and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 3-4 cycloalkyl.

[0159] R 3 is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2Alkoxy and C unsubstituted or substituted by one substituent selected from -F and -OMe 3-4 cycloalkyl.

[0160] R 3 is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2 It is selected from alkoxy and cyclopropyl.

[0161] R 3 is -H.

[0162] R 4 is -H, -F, unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 Alkoxy and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkyl.

[0163] R 4 is -H, -F, and C which is unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 Alkoxy is selected from:

[0164] R 4 is -F and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 Alkoxy is selected from:

[0165] R 4 is -F and C which is unsubstituted or substituted by 1 to 2 substituents selected from -F and -OMe 1-3 Alkoxy is selected from:

[0166] R 4 is -F and C which is unsubstituted or substituted by 1 to 2 substituents selected from -F and -OMe 1-3 Alkoxy is selected from:

[0167] R 4 is unsubstituted or substituted by 1 to 2 substituents selected from -F and -OMe 1-3 It is an alkoxy.

[0168] R 4 is -OMe or -OEt.

[0169] R 4 is not -H.

[0170] R 4 is selected from -F and -OMe.

[0171] R 4 is -OMe.

[0172] R 2 and R 3 together with the atoms to which they are attached form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; and U and V are each C.

[0173] R 3 and R 4 are taken together with the atoms to which they are attached to form a 5- or 6-membered heterocyclic ring having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and which is unsubstituted or substituted with 1 to 3 -Me substituents; and V and W are each C. Optionally, R 3 and R 4 is R 3 , R 4 , the ring containing V and W [ka] wherein the ring is unsubstituted or optionally substituted with 1-2 -Me substituents. 3 and R 4is R 3 , R 4 , the ring containing V and W [ka] is selected to be.

[0174] In one embodiment, R 2 is -CN and R 3 is -H, and R 4 is -OMe and R 5 is -H.

[0175] In one embodiment, R 2 is -F and R 3 is -H, and R 4 is -OMe and R 5 is -H.

[0176] In one embodiment, A is [ka] and Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, or a 4- to 10-membered cycloalkenyl; R 7 is selected from -H, -F, -CH3 and -OCH3; Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl; C 1-4 Alkoxy; -OH; -F and -COO(C 1-4 alkyl), p is 0, 1 or 2; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 4- to 10-membered cycloalkenyl, or a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; Each R 9 is C 1-4 Alkyl, C 1-4 independently selected from alkoxy, -halo, and -OH; q is 0, 1 or 2; R 1 are -COOH, -CONH2, -CONHMe, -CONMe2, -C(CH2OH)2NH2, -C(NH)NH2, -SO2NH2, -NHSO2Me, [ka] is selected from X is selected from a bond, —CH—, —O—, —S—, —CHO—, and —OCH—; Y is unsubstituted or 1 to 2 R 14 C substituted by a substituent 2-6 Alkylene; unsubstituted or 1 to 2 R 14 C substituted by a substituent 3-8 Cycloalkylene; unsubstituted or 1-2 R 14 C substituted by a substituent 5-8 Cycloalkenylene; having 1 to 3 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 2 R 14 5-8 membered heterocycloalkylene substituted by a substituent; unsubstituted or 1-2 R 14 phenylene substituted by a substituent; phenylene having 1 to 3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and unsubstituted or having 1 to 2 R 14 5- or 6-membered heteroarylene substituted by substituents; and [ka] is selected from R14 is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and CN; 1-3 Alkyl; C unsubstituted or substituted with 1 to 3 -F substituents 1-3 alkoxy; cyclopropyl which is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2; Z is a bond; C which is unsubstituted or substituted by 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 1-3 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted with 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 2-4 Heteroalkylene; C 3-4 selected from cycloalkylene and -CH=CH-; R 5 is selected from -H, -Me and -F; R 6 is -(CR 10 R 11 ) n R 12 and n is 0, 1 or 2; R 10 and R 11 are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl, R 12 is unsubstituted or -OH, -F, -CN and C 1-4 C substituted by 1 to 5 substituents selected from alkoxy 3-8 Alkyl; unsubstituted or 1 to 4 R 13 C substituted by a substituent 3-10 Cycloalkyl; having 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or having 1 to 4 R 135-10 membered heterocycloalkyl substituted by substituents; unsubstituted or -halo, unsubstituted or substituted by 1-3 F substituents 1-4 Alkyl, C 3-5 phenyl substituted by 1 to 3 substituents selected from cycloalkyl, -CN, -SF5, -OMe, -OCH2F, -OCHF2, -OCF3 and SO2CF3; 6-membered heteroaryl having 1 to 2 nitrogen heteroatoms and substituted by 1 to 3 substituents selected from -halo, -SF5, -CF3, -OCF3 and -SO2CF3; [ka] is selected from Each R 13 is -OH; -F; -CN; C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 Alkoxy and C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 independently selected from alkyl, U, V, and W are each independently selected from C and N, provided that when U is N, R 2 is absent and V is N, then R 3 does not exist and W is N, then R 4 does not exist, R 2 and R 3 are each independently -C, unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe; 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy; R 4is -F, and C which is unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe; 1-4 alkoxy, and optionally R 4 is unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 alkoxy, optionally R 4 is -OMe.

[0177] In one embodiment, A is [ka] and Ring B is a 4- to 10-membered cycloalkyl; a 4- to 10-membered heterocycloalkyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen, or a 4- to 10-membered cycloalkenyl; R 7 is -H, Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-4 Alkyl; C 1-4 Alkoxy; -OH; -F; and -COO(C 1-4 alkyl), p is 0, 1 or 2, optionally p is 0; Ring C is a 6- to 10-membered aryl; a 5- to 10-membered heteroaryl having 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 4- to 10-membered cycloalkenyl, or a 4- to 10-membered heterocycloalkenyl having 1 to 2 heteroatoms independently selected from nitrogen and oxygen; Each R 9 is C 1-4 Alkyl, C 1-4 independently selected from alkoxy, -halo, and -OH; q is 0, 1 or 2, optionally q is 0; R 1 is -COOH, X is selected from a bond, —CH—, —O—, —S—, —CHO—, and —OCH—; optionally, X is —O—; Y is [ka] and, in some cases, [ka] and r is 1 or 2; R 14 is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; 1-3 Alkyl; C unsubstituted or substituted with 1 to 3 -F substituents 1-3 alkoxy; cyclopropyl which is unsubstituted or substituted with 1 to 3 substituents selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2; Z is a bond; C which is unsubstituted or substituted by 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 1-3 alkylene; C having one heteroatom selected from nitrogen and oxygen, unsubstituted or substituted with 1 to 2 substituents selected from -Me, -NH2, -NHMe and -NMe2 2-4 Heteroalkylene; C 3-4 selected from cycloalkylene and -CH=CH-, and optionally Z is a bond; R 5 is selected from -H, -Me and -F, and optionally R 5 is -H, R 6 is -(CR 10 R 11 ) n R 12 and n is 0, 1 or 2; R 10 and R 11are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl, R 12 is unsubstituted or -F, -CN and C 1-2 C substituted by 1 to 3 substituents selected from alkoxy 4-6 Alkyl; unsubstituted or 1 to 3 R 13 C substituted by a substituent 4-6 cycloalkyl and 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or 1 to 3 R 13 substituted 5- to 6-membered heterocycloalkyl; or R 12 teeth, [ka] each unsubstituted or substituted with one substituent selected from -halo, -Me, -CF3 and -CN; Each R 13 is -OH; -F; -CN; C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 Alkoxy and C unsubstituted or substituted with 1 to 3 substituents selected from -F, -OH, -OMe and -OEt 1-4 independently selected from alkyl, U, V, and W are each independently selected from C and N, provided that when U is N, R 2 is absent and V is N, then R 3 does not exist and W is N, then R 4 does not exist, R 2 and R 3 are each independently -C, unsubstituted or substituted with 1 to 3 substituents selected from -H, -halo, -CN, -F and -OMe; 1-4C unsubstituted or substituted with 1 to 3 substituents selected from alkyl, -F and -OMe 1-4 C unsubstituted or substituted with 1 to 3 substituents selected from alkoxy, -F and -OMe 3-4 Cycloalkyl and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -Me 3-4 cycloalkoxy; R 4 is -F and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 alkoxy, and optionally R 4 is unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 alkoxy, optionally R 4 is -OMe.

[0178] In one embodiment, A is [ka] and Ring B is a 5- to 8-membered cycloalkyl or a 5- to 8-membered cycloalkenyl, R 7 is selected from -H and -F; Each R 8 is unsubstituted or substituted by 1 to 3 -F substituents 1-2 independently selected from alkyl and -F; p is 0 or 1, optionally p is 0; R 1 are -COOH, -CONH2, [ka] is selected from X is —O—; Y is [ka] and, in some cases, [ka] and r is 1 or 2; R 14 is a C which is unsubstituted or substituted by one substituent selected from -OH, -OMe, -F and -CN; 1-2 Alkyl; C unsubstituted or substituted with one -F substituent 1-2 alkoxy; cyclopropyl which is unsubstituted or substituted by one substituent selected from -OH, -OMe, -F and -CN; -F; -OH; =O; -CN; -NH2; -NHMe and -NMe2; Z is a bond, R 5 is -H, R 6 is -(CR 10 R 11 ) n R 12 and n is 0 or 1, optionally n is 1; R 10 and R 11 are each independently selected from -H, -Me and -F, or R 10 and R 11 together with the carbon to which they are attached form a cyclopropyl, R 12 is unsubstituted or -F, -CN and C 1-2 C substituted by 1 to 3 substituents selected from alkoxy 4-6 Alkyl; unsubstituted or 1 to 3 R 13 C substituted by a substituent 4-6 cycloalkyl and 1 to 2 heteroatoms independently selected from oxygen and sulfur, unsubstituted or 1 to 3 R 13 substituted 5- to 6-membered heterocycloalkyl; or R 12 teeth, [ka] each unsubstituted or each substituted with one substituent selected from -halo, -Me, -CF3, and -CN; Each R 13 is -F; -CN; C unsubstituted or substituted by one substituent selected from -F, -OMe and -OEt 1-2 Alkoxy and C unsubstituted or substituted by one substituent selected from -F, -OMe and -OEt 1-2 independently selected from alkyl, U, V and W are each C; R 2 is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2 alkoxy and cyclopropyl, and optionally R 2 is -F or -CN, R 3 is -H, -halo, -CN, C unsubstituted or substituted with 1 to 3 -F substituents 1-2 Alkyl, unsubstituted or substituted with one -OMe substituent 1-2 alkoxy and cyclopropyl, and optionally R 3 is -H, R 4 is -F and C unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 alkoxy, and optionally R 4 is unsubstituted or substituted by 1 to 3 substituents selected from -F and -OMe 1-4 alkoxy, optionally R 4 is -OMe.

[0179] In an embodiment, a compound of Formula (IIa) or Formula (IIb): [ka] [In the formula, R 2 and R 6 is as defined for formula (I). or a pharmaceutically acceptable salt thereof.

[0180] In an embodiment, Formula (IIa) or Formula (IIb) [In the formula, R 2 is -F or -CN, and R 6 teeth, [ka] Select from or a pharmaceutically acceptable salt thereof.

[0181] In an embodiment, Formula (IIa) or Formula (IIb) [In the formula, R 2 is -F and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0182] In an embodiment, Formula (IIa) or Formula (IIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0183] In an embodiment, Formula (IIa) or Formula (IIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0184] In an embodiment, Formula (IIa) or Formula (IIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0185] In an embodiment, a compound of Formula (IIIa) or Formula (IIIb): [ka] [In the formula, R 2 and R 6 is as defined for formula (I). or a pharmaceutically acceptable salt thereof.

[0186] In an embodiment, Formula (IIIa) or Formula (IIIb) [In the formula, R 2 is -F or -CN, and R 6 teeth, [ka] Select from or a pharmaceutically acceptable salt thereof.

[0187] In an embodiment, Formula (IIIa) or Formula (IIIb) [In the formula, R 2 is -F and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0188] In an embodiment, Formula (IIIa) or Formula (IIIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0189] In an embodiment, Formula (IIIa) or Formula (IIIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0190] In an embodiment, Formula (IIIa) or Formula (IIIb) [In the formula, R 2 is -CN and R 6 teeth, [ka] is] or a pharmaceutically acceptable salt thereof.

[0191] In an embodiment, the compound of formula (IIIa) [In the formula, R 2 is -F or -CN, and R 6 teeth, [ka] Select from or a pharmaceutically acceptable salt thereof.

[0192] In an embodiment, a compound of Formula (IVa) or Formula (IVb): [ka] [In the formula, R 2 and R 6 is as defined for formula (I). or a pharmaceutically acceptable salt thereof.

[0193] In an embodiment, a compound of formula (IVa) or formula (IVb) [In the formula, R 2 is -F or -CN, and R 6 teeth, [ka] Select from or a pharmaceutically acceptable salt thereof.

[0194] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0195] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0196] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0197] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0198] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0199] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0200] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0201] In an embodiment, the compound of formula (I) is [ka] or a pharmaceutically acceptable salt thereof.

[0202] In an embodiment, the compound of formula (I) is [ka] is.

[0203] In an embodiment, the compound of formula (I) is [ka] is.

[0204] In an embodiment, the compound of formula (I) is [ka] is.

[0205] In an embodiment, the compound of formula (I) is [ka] is.

[0206] In embodiments, a compound is provided that is any one of the compounds from Compound List A, or a pharmaceutically acceptable salt thereof.

[0207] In embodiments, a compound is provided that is any one of the compounds from Compound List A.

[0208] In an embodiment, the compound of formula (I) is selected from the compounds of compound list A or a pharmaceutically acceptable salt thereof.

[0209] In an embodiment, the compound of formula (I) is selected from the compounds of compound list A.

[0210] Compound List A: 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((cyclobutylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-(fluoromethoxy)-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methyl-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 6-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)spiro[3.3]heptane-2-carboxylic acid; 4-(2-fluoro-5-((3-(isopropylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-(fluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((2-(trifluoromethyl)pyridin-4-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((5-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((perfluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-fluoro-5-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((2-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-cyano-4-methylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3,5-bis(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((4-bromo-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((2-methyl-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-chlorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((2-chloro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-bromo-4-cyanophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((4-cyano-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((5-chloropyridazin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((6-(trifluoromethyl)pyrimidin-4-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-(trifluoromethyl)pyrimidin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-(isobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((2,2-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((1-(1-methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((2,4-dimethylpentan-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((2-cyano-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((4-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide; 4-(5-((3-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-methylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-((2,2-dimethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-((2-ethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-((3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-((2,4-dimethylpentan-3-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((1-(1-methylcyclopropyl)ethyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclohexyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-(isobutylcarbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-((2-cyano-2-methylpropyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((cyclopropylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((1-cyanocyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((3-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-hydroxycyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-(hydroxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((1-fluoro-2-methylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-isopropylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-(methoxymethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((adamantan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((cycloheptylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-propylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((2,2,3,3-tetramethylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-(isopropylamino)-2-oxoethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((3,3-dimethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-fluoro-3-hydroxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((1-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-fluorocyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2,2-difluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-fluoro-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((1-methylcyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((4,4-difluoro-1-hydroxycyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-hydroxycycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-(ethoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-isobutylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((4-cyanocyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2-phenylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((1-(hydroxymethyl)cyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methoxycyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-([1,1'-bi(cyclopropane)]-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-hydroxyadamantan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(((4-(difluoromethyl)pyrimidin-2-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(propylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(hexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2-phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((1-cyclohexylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-isopropoxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3,4-difluorobenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((3-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(tert-pentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((4,4-dimethylcyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3,3-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-fluoro-2-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-cyclopropylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((2-(2,2,2-trifluoroethyl)cyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-fluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((2,5-dimethylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((3-methylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((1-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((4-fluorotetrahydro-2H-pyran-4-yl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; 3-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(((1-methylcyclobutyl)methyl)carbamoyl)pyridin-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-methyl-5-(((1-methylcyclobutyl)methyl)carbamoyl)isothiazol-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((4-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)thiophen-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-methyl-6-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-((cycloheptylmethyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-(((1-phenylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-(((3-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-(((1-fluorocyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)-5-chlorophenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-((3-fluoro-3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-(tert-pentylcarbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-((2-fluoro-2-methylpropyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((5-chloro-2-((2-cyclopropylpropan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((2-((3-fluorobenzyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((2-((2-ethylbutyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-(pentan-3-ylcarbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-((4-methylcyclohexyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-((3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-((3-methylcyclobutyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((2-(((1-fluorocyclobutyl)methyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)-5-methylphenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((5-methyl-2-(((1-methylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4,4,4-trifluorobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((4-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-(pentafluoro-λ 6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((2,6-difluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-iodophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3,4,5-trifluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-methyl-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-(tert-butyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-cyclopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-cyano-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-methyl-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-methoxy-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3-(difluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-isopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(5-((3-((3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(phenylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((2-methylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-(difluoromethoxy)-2-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-((4-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 4-(5-((2,4-dimethyl-6-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((4,5-dimethyl-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclohex-1-en-1-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopent-1-en-1-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)naphthalen-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-methyl-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)pyrazolo[1,5-a]pyrimidin-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(4-Methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)propanoic acid; 3-(5-((1H-pyrazol-4-yl)methyl)-4-fluoro-2-methoxybenzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 2-(4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazol-1-yl)acetic acid; 1-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazole-5-carboxylic acid; 1-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazole-3-carboxylic acid; 2-(4-Methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)benzyl)benzoic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-3,4'-dimethoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)-1H-pyrrole-2-carboxylic acid; 2'-Fluoro-4,4'-dimethoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2',4-Difluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2',3-Difluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 2-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-yl)acetic acid; 2',3-Difluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-2-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid; 3-(Dimethylamino)-2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 4-((2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)butanoic acid; 2'-Fluoro-4'-methoxy-3,5-dimethyl-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2-(6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3-dihydrobenzofuran-3-yl)acetic acid; (5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-2-yl)glycine; 2-((5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)oxy)acetic acid; 3-(6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-3-yl)propanoic acid; 2-((2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)-2-methylpropanoic acid; 2-((2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; 3-(2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)thiazol-5-yl)propanoic acid; 3-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 3-(6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridazin-3-yl)propanoic acid; 2'-Fluoro-4'-methoxy-3-methyl-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-3-hydroxy-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)propanoic acid; 3-(2'-Fluoro-3,4'-dimethoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (E)-3-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)acrylic acid; 2-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)cyclopropane-1-carboxylic acid; 2-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane-1-carboxylic acid; 3-(6-fluoro-4-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4'-(2-amino-1,3-dihydroxypropan-2-yl)-6-fluoro-4-methoxy-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4'-(3-amino-4-hydroxy-3-(hydroxymethyl)butyl)-3',6-difluoro-4-methoxy-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2-oxopyridin-1(2H)-yl)propanoic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-1H-pyrazol-1-yl)propanoic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)cyclohexane-1-carboxylic acid; 6-Fluoro-4-methoxy-N3-(3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)-[1,1'-biphenyl]-3,4'-dicarboxamide; 2-(4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)-1H-pyrazol-1-yl)acetic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-carboxylic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)oxazole-4-carboxylic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid; 2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)isonicotinic acid; 6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid; 2-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 3-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 3-(2'-Fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-3-carboxylic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-2-carboxylic acid; 2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-4-carboxylic acid; 2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-5-carboxylic acid; 1-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid; 2-(Dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 2-amino-3-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 2-(Dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 2-(Dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 2-(Dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 2'-Fluoro-5'-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-5'-((3-((3-fluoro-5-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2',4'-difluoro-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-((3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-((3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-((3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-((1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-((3-((1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4-hydroxy-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2-(2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 3-(2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 2-(2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 3-(2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-1,3,4-thiadiazol-2-yl)propanoic acid; 3-(2-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-5-yl)propanoic acid; 3-(6-fluoro-4-methoxy-4'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)phenyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2-((2'-cyano-4'-methoxy-5'-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; 2-((2'-Fluoro-4'-methoxy-5'-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((7-(tert-butoxycarbonyl)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-methoxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-methoxy-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((4-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((4-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-fluoro-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-methoxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclohexyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-(trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-(trifluoromethyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-(difluoromethyl)-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(3-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-methoxy-2-methyl-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-ethyl-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-cyano-2-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 1-methyl-4-((1-methyl-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-1H-indazol-7-yl)oxy)cyclohexane-1-carboxylic acid; 1-methyl-4-((1-methyl-6-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-1H-indazol-4-yl)oxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-(methoxymethyl)-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-methoxy-3-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxy-2-methylphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-ethyl-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-ethoxy-2-fluoro-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-ethoxy-2-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 1-ethyl-4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(3-fluoro-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-(2-methoxyethoxy)-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-chloro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2,4-difluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((2,3-dihydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-hydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-chloro-2-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyclopropyl-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-methoxy-2-(methoxymethyl)-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(3-chloro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(3-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(4-methoxy-3-methyl-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 1-methyl-4-((7-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3-dihydrobenzofuran-5-yl)oxy)cyclohexane-1-carboxylic acid; 1-methyl-4-((8-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)quinolin-6-yl)oxy)cyclohexane-1-carboxylic acid; 4-(2-chloro-4-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-chloro-4-methoxy-5-((3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-chloro-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-chloro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 1-fluoro-4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 1-fluoro-4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclohexyl)oxy)benzamide)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)cyclohexyl)oxy)benzamide)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4-fluoro-2-methoxy-5-((4-methyl-4-(1H-tetrazol-5-yl)cyclohexyl)oxy)benzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(5-((4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-hydroxycyclohexane-1-carboxylic acid; 1-(cyanomethyl)-4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 3-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)bicyclo[3.1.0]hexane-6-carboxylic acid; 4-(4-Methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 3-(4-Methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 2-(4-Methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(2,4-difluoro-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 5-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-2,2-dimethylpentanoic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(3-(pentafluoro-λ6 -sulfanyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 6-Fluoro-4-methoxy-N3-(3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)-[1,1'-biphenyl]-3,4'-dicarboxamide; 6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)hexanoic acid; 7-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)heptanoic acid; 9-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)nonanoic acid; 4-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 4-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclohexane-1-carboxylic acid; 4-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)bicyclo[2.2.2]octane-1-carboxylic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid; 3-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutane-1-carboxylic acid; 3-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 2-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 3-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 4-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 5-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)pentanoic acid; 2-(4-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 2-(3-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid; 2-(3-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 6-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)hexanoic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)butanoic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 1-amino-4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 3-(4-fluoro-2-methoxy-5-((4-(methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 4-(2-fluoro-4-methoxy-5-((6-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)hexahydro-4,7-methanobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 3-(4-fluoro-2-methoxy-5-((4-sulfamoylcyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 4-(2-bromo-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(4-methoxy-2-methyl-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(4-methoxy-3-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-((2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclobutane-1-carboxylic acid; 2-(3-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutyl)acetic acid; 2-(4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexyl)acetic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(trifluoromethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(2-fluoro-4-isopropoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxycarbonyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-isopropoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(5-((1-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(pentafluoro-λ 6 -sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((4,4-difluoro-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(5-((5,6-dihydroxy-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((4-hydroxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((4-methoxy-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide; 3-(5-((4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 4-(2-cyano-4-methoxy-5-((3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((2,2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methoxycyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-hydroxycyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methoxycyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-fluoro-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 2'-Fluoro-5'-((3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-(methoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(((1-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((3,3,3-trifluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((1,1,1-trifluoropropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((1,1,1-trifluoro-2-methylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((1-((trifluoromethyl)sulfonyl)pyrrolidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-(((1-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-5-((3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-(trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-(((1-(trifluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((3-cyano-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(((1-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-fluoro-4-methoxy-5-((3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(5-((3-(((3,3-difluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; 4-(2-cyano-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; and 4-(2-cyano-5-((3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid.

[0211] In a further embodiment, (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,3R,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((cyclobutylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-(fluoromethoxy)-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methyl-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (2R,4r,6R)-6-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)spiro[3.3]heptane-2-carboxylic acid; (2S,4s,6S)-6-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)spiro[3.3]heptane-2-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(isopropylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-(fluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((2-(trifluoromethyl)pyridin-4-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((5-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((perfluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-fluoro-5-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((2-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-cyano-4-methylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((4-fluoro-3-(trifluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3,5-bis(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((4-bromo-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((2-methyl-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-chlorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2-chloro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-bromo-4-cyanophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((4-cyano-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((5-chloropyridazin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((6-(trifluoromethyl)pyrimidin-4-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4-(trifluoromethyl)pyrimidin-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(isobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2,2-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-1-(1-methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-1-(1-methylcyclopropyl)ethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2,4-dimethylpentan-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2-cyano-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2S,3R,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2R,3S,4S)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((3S,4R)-4-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide; (1s,4s)-4-(5-((3-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((S)-3-methylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2,2-dimethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2-ethylbutyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((R)-3-methylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2,4-dimethylpentan-3-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((R)-1-(1-methylcyclopropyl)ethyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((S)-1-(1-methylcyclopropyl)ethyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclohexyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-(isobutylcarbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclopropyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1R,2S)-2-((2-cyano-2-methylpropyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((cyclopropylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((1-cyanocyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1s,3R)-3-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-hydroxycyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-(hydroxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((1-fluoro-2-methylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-isopropylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-(methoxymethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((3S,5S)-adamantan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((cycloheptylmethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-propylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((2,2,3,3-tetramethylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2-(isopropylamino)-2-oxoethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((3,3-dimethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((S)-2-fluoro-3-hydroxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((1-methylcyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-fluorocyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-(fluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2,2-difluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2-fluoro-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((1-methylcyclopropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((4,4-difluoro-1-hydroxycyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-hydroxycycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-(ethoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcycloheptyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-isobutylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((4-cyanocyclohexyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((2-phenylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1-(hydroxymethyl)cyclopentyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methoxycyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-([1,1'-bi(cyclopropane)]-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((1r,3S)-3-hydroxyadamantan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((4-(difluoromethyl)pyrimidin-2-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(propylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(hexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-2-phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((R)-1-cyclohexylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(cyclohexylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-isopropoxypropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3,4-difluorobenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((((1s,3R)-3-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-2-phenylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(tert-pentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((4,4-dimethylcyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3,3-dimethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(((S)-2-fluoro-2-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-cyclopropylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1S,2S)-2-(2,2,2-trifluoroethyl)cyclohexyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-fluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((2,5-dimethylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-methylbenzyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-1-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-1-phenylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((2-(neopentylcarbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((R)-3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((S)-3-ethylpentan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((4-fluorotetrahydro-2H-pyran-4-yl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,3s)-3-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; (1S,3s)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((4-(((1-methylcyclobutyl)methyl)carbamoyl)pyridin-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclooctyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((3-methyl-5-(((1-methylcyclobutyl)methyl)carbamoyl)isothiazol-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((4-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((2-(((1-methylcyclobutyl)methyl)carbamoyl)thiophen-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((2-methyl-6-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-((cycloheptylmethyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-(((1-phenylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-((((1s,3s)-3-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-(((1-fluorocyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((2-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)-5-chlorophenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-((5-chloro-2-(((R)-3-fluoro-3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-(tert-pentylcarbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-((2-fluoro-2-methylpropyl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((5-chloro-2-((2-cyclopropylpropan-2-yl)carbamoyl)phenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-5-((2-((3-fluorobenzyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-5-((2-((2-ethylbutyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(pentan-3-ylcarbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((1r,4r)-4-methylcyclohexyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((R)-3-methylbutan-2-yl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((1s,3s)-3-methylcyclobutyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-5-((2-(((1-fluorocyclobutyl)methyl)carbamoyl)-5-methylphenyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((2-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)-5-methylphenyl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-cyano-4-methoxy-5-((5-methyl-2-(((1-methylcyclopropyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4,4,4-trifluorobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2-cyclopropylethyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((4-(difluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2,6-difluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-iodophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3,4,5-trifluorophenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-methyl-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-(tert-butyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-cyclopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-cyano-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((4-methyl-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-methoxy-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-(difluoromethoxy)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-isopropylphenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((2-ethylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((S)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((R)-3,3-dimethylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(phenylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-2-methylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-2-methylbutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1-methylcyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3R,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2S,3R,4S)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-(difluoromethoxy)-2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((4-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; (1s,4s)-4-(5-((2,4-dimethyl-6-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(5-((4,5-dimethyl-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclohex-1-en-1-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-5-((2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopent-1-en-1-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)naphthalen-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((4-methyl-2-(((1-methylcyclobutyl)methyl)carbamoyl)phenyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1s,4s)-4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)pyrazolo[1,5-a]pyrimidin-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 3-(4-Methoxy-3-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)propanoic acid; 3-(4-Methoxy-3-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)propanoic acid; (1R,2S,3R,4S)-3-(5-((1H-pyrazol-4-yl)methyl)-4-fluoro-2-methoxybenzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 2-(4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazol-1-yl)acetic acid; 1-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazole-5-carboxylic acid; 1-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)benzyl)-1H-pyrazole-3-carboxylic acid; 2-(4-methoxy-3-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)benzyl)benzoic acid; 2-(4-methoxy-3-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)benzyl)benzoic acid; 2'-Fluoro-3,4'-dimethoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-3,4'-dimethoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)-1H-pyrrole-2-carboxylic acid; 4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)-1H-pyrrole-2-carboxylic acid; 2'-Fluoro-4,4'-dimethoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4,4'-dimethoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2',4-Difluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2',4-Difluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2',3-Difluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2',3-Difluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2,2'-Difluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-yl)acetic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-yl)acetic acid; 2',3-Difluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-2-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid; 3-(Dimethylamino)-2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 4-((2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)butanoic acid; 2'-Fluoro-4'-methoxy-3,5-dimethyl-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2-((S)-6-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3-dihydrobenzofuran-3-yl)acetic acid; 2-((R)-6-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2,3-dihydrobenzofuran-3-yl)acetic acid; (5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-2-yl)glycine; 2-((5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)oxy)acetic acid; 3-(6-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-3-yl)propanoic acid; 2-((2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)-2-methylpropanoic acid; 2-((2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; 3-(2-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)thiazol-5-yl)propanoic acid; 3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 3-(6-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridazin-3-yl)propanoic acid; 2'-Fluoro-4'-methoxy-3-methyl-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-3-hydroxy-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)propanoic acid; 3-(2'-Fluoro-3,4'-dimethoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (E)-3-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)acrylic acid; (1R,2R)-2-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)cyclopropane-1-carboxylic acid; (1S,2S)-2-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyridin-2-yl)cyclopropane-1-carboxylic acid; (1R,2R)-2-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane-1-carboxylic acid; (1S,2S)-2-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)cyclopropane-1-carboxylic acid; (1R,2S,3R,4S)-3-(6-fluoro-4-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2S,3R,4S)-3-(4'-(2-amino-1,3-dihydroxypropan-2-yl)-6-fluoro-4-methoxy-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2S,3R,4S)-3-(4'-(3-amino-4-hydroxy-3-(hydroxymethyl)butyl)-3',6-difluoro-4-methoxy-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 3-(4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-2-oxopyridin-1(2H)-yl)propanoic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 3-(4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-1H-pyrazol-1-yl)propanoic acid; (R)-2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid; (S)-2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)cyclohexane-1-carboxylic acid; 6-Fluoro-4-methoxy-N3-((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)-[1,1'-biphenyl]-3,4'-dicarboxamide; 2-(4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)-1H-pyrazol-1-yl)acetic acid; 4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-2-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 2-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)oxazole-4-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)oxazole-4-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrazine-2-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)isonicotinic acid; 2-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)isonicotinic acid; 6-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 6-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)nicotinic acid; 6-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 6-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)picolinic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)pyrimidine-2-carboxylic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 2-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 3-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 3-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 3-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 3-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-3-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-3-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-2-carboxylic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiophene-2-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-4-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-4-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-5-carboxylic acid; 2-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenyl)thiazole-5-carboxylic acid; 1-(2'-fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid; 1-(2'-fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid; (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1R,2S,3R,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1R,2S,3R,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (R)-2-amino-3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; (R)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; (S)-2-(dimethylamino)-3-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; (R)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; (S)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; (R)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; (S)-2-(dimethylamino)-2-(2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((3-fluoro-5-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((3-fluoro-5-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2',4'-difluoro-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2',4'-difluoro-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1R,2R,3S,4S)-3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2S,3R,4R)-3-((3-fluoro-5-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-(((1R,2R,3S,4S)-3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-(((1S,2S,3R,4R)-3-((3-cyano-4-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-(((1R,2R,3S,4S)-3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 5'-(((1S,2S,3R,4R)-3-((3-cyano-5-fluorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-(((S)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-(((S)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2S,3R,4S)-3-(((S)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-(((S)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-(((R)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-(((R)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2-(2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-yl)acetic acid; 3-(2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-3-yl)propanoic acid; 2-(2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-yl)acetic acid; 3-(2'-Fluoro-4'-methoxy-5'-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-[1,1'-biphenyl]-4-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)-1,3,4-thiadiazol-2-yl)propanoic acid; 3-(2-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrimidin-5-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid; 3-(5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenyl)pyrazin-2-yl)propanoic acid; (1R,2S,3R,4S)-3-(6-fluoro-4-methoxy-4'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2R,3S,4S)-3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,2S,3R,4R)-3-(6-fluoro-4-methoxy-4'-(2-sulfamoylethyl)-[1,1'-biphenyl]-3-carboxamide)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 2'-Fluoro-4'-methoxy-5'-((2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)phenyl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2-((2'-cyano-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; 2-((2'-fluoro-4'-methoxy-5'-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-4-yl)oxy)acetic acid; (1R,4s)-4-(5-(((1R,2R,3S,4S)-7-(tert-butoxycarbonyl)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((1S,2S,3R,4R)-7-(tert-butoxycarbonyl)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-cyano-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2R)-2-fluoro-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((2S,3R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((2S,3R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,3R,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclohexyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-(trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-(trifluoromethyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-(difluoromethyl)-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(3-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-2-methyl-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-ethyl-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-cyano-2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-1-methyl-4-((1-methyl-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-1H-indazol-7-yl)oxy)cyclohexane-1-carboxylic acid; (1S,4s)-1-methyl-4-((1-methyl-6-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-1H-indazol-4-yl)oxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-(methoxymethyl)-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-3-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxy-2-methylphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-ethyl-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-ethoxy-2-fluoro-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-ethoxy-2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-1-ethyl-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2S,3R,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(3-fluoro-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-(2-methoxyethoxy)-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2,4-difluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2R,5S)-2-hydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2S,5R)-2-hydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,5S)-2-methoxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,5R)-2-methoxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-chloro-2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyclopropyl-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-2-(methoxymethyl)-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(3-chloro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(3-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-3-methyl-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-1-methyl-4-((7-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2,3-dihydrobenzofuran-5-yl)oxy)cyclohexane-1-carboxylic acid; (1S,4s)-1-methyl-4-((8-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)quinolin-6-yl)oxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-4-fluoro-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-chloro-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-fluoro-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2S,3R,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4r)-1-fluoro-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4r)-1-fluoro-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclohexyl)oxy)benzamide)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)cyclohexyl)oxy)benzamide)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-(1H-tetrazol-5-yl)cyclohexyl)oxy)benzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,2S,3R,4R)-3-(5-(((1s,4S)-4-carbamoyl-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,4r)-1-(cyanomethyl)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-1-(cyanomethyl)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,3s,5S,6S)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)bicyclo[3.1.0]hexane-6-carboxylic acid; (1R,3r,5S,6R)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)bicyclo[3.1.0]hexane-6-carboxylic acid; (1R,3r,5S,6S)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)bicyclo[3.1.0]hexane-6-carboxylic acid; (1R,3s,5S,6R)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)bicyclo[3.1.0]hexane-6-carboxylic acid; 4-(4-methoxy-3-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(4-methoxy-3-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 3-(4-Methoxy-3-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 3-(4-Methoxy-3-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 2-(4-methoxy-3-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 2-(4-Methoxy-3-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; (1S,4s)-4-(2,4-difluoro-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 5-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-2,2-dimethylpentanoic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,2S,3R,4R)-3-(5-(((1s,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(3-(pentafluoro-λ6-sulfanyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; 6-Fluoro-4-methoxy-N3-((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)-[1,1'-biphenyl]-3,4'-dicarboxamide; 6-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)hexanoic acid; 7-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)heptanoic acid; 9-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)nonanoic acid; 4-((2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; (1R,4r)-4-((2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-((2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclohexane-1-carboxylic acid; 4-((2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)bicyclo[2.2.2]octane-1-carboxylic acid; (2R,5R)-5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid; (2S,5S)-5-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid; (1R,3r)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutane-1-carboxylic acid; (1S,3s)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,3R)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,3S)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,3S)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,3R)-3-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; 2-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 2-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 3-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 3-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 4-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 4-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)benzoic acid; 5-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)pentanoic acid; 5-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)pentanoic acid; 2-(4-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 2-(4-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 2-(3-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid; 2-(3-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)acetic acid; 2-(3-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 2-(3-((2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)methyl)phenyl)-2-methylpropanoic acid; 6-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)hexanoic acid; 6-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)hexanoic acid; 4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)butanoic acid; 4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)butanoic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4r)-1-amino-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-1-amino-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-(methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1r,4R)-4-(methylsulfonamido)cyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((3aS,4S,5R,6S,7R,7aR)-6-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)hexahydro-4,7-methanobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((1r,4R)-4-sulfamoylcyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-sulfamoylcyclohexyl)oxy)benzamido)-N-(3-((trifluoromethyl)sulfonyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,4s)-4-(2-bromo-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-2-methyl-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(4-methoxy-3-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,3r)-3-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclobutane-1-carboxylic acid; (1S,3s)-3-((2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)methyl)cyclobutane-1-carboxylic acid; 2-((1R,3r)-3-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutyl)acetic acid; 2-((1S,3s)-3-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclobutyl)acetic acid; 2-((1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexyl)acetic acid; 2-((1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexyl)acetic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(trifluoromethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxymethyl)cyclohexane-1-carboxylic acid; 4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; 4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)benzoic acid; (1R,4r)-4-(2-fluoro-4-isopropoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(methoxycarbonyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-isopropoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2R,3S,4S)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2R,3S,4S)-3-((4-fluoro-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2S)-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((1S,2R)-4,4-difluoro-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((1R,2S)-4,4-difluoro-2-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R,5R,6S)-5,6-dihydroxy-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2R,4S)-4-hydroxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2S,4R)-4-hydroxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((4-methoxy-3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1R,2R,3S,4S)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,2S,3R,4R)-3-(5-(((1s,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide; (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carbamoylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)-N-(4-fluoro-3-(trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-2-carboxamide; (1R,4s)-4-(2-fluoro-5-(((1S,2S,3R,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-4-methoxyphenoxy)cyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((R)-2,2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((S)-2,2-dimethylcyclopentyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,3s)-3-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclobutane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methoxycyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-hydroxycyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methoxycyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3aR,4S,5S,6aS)-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3aS,4R,5R,6aR)-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((3R,4S)-1-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((3S,4R)-1-acetyl-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)piperidin-4-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cycloheptyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-4-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2S,3R,4R)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2R,3S,4S)-3-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,4S)-4-methoxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,4R)-4-methoxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,4R)-4-methoxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,4S)-4-methoxy-2-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,5S)-2-methoxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,5R)-2-methoxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2S,5S)-2-hydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2R,5R)-2-hydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2S,3R,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-oxabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2S,3R,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-(3,3,3-trifluoropropyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)-7-(3,3,3-trifluoropropyl)-7-azabicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((2S,3R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((2R,3S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2S,3R,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((2S,3R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((2R,3S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,3R,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]oct-5-en-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,4R)-4-methoxy-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,4S)-4-methoxy-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,4R)-4-methoxy-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,4S)-4-methoxy-2-(neopentylcarbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,4R)-4-methoxy-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S,4S)-4-methoxy-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclopentyl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4'-methoxy-5'-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4-hydroxy-4'-methoxy-5'-(((1R,2S,3R,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; 2'-Fluoro-4-hydroxy-4'-methoxy-5'-(((1S,2R,3S,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-[1,1'-biphenyl]-3-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4S)-4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4R)-4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((1S,2R,3S,5S)-2,3-dihydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(5-(((1R,2S,3R,5R)-2,3-dihydroxy-5-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)cyclopentyl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((3S,4R)-4-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((3R,4S)-4-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R)-2-(neopentylcarbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2S)-2-(neopentylcarbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1S,2R)-2-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((1R,2S)-2-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)cyclobutyl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-methoxy-5-(((1R,2S)-2-(((1-methylcyclobutyl)methyl)carbamoyl)cyclobutyl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((3S,4S)-4-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-5-(((3R,4R)-4-((4-fluoro-3-(pentafluoro-λ6-sulfanyl)phenyl)carbamoyl)tetrahydro-2H-pyran-3-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(neopentylcarbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3S,4R)-4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((3R,4S)-4-(((1-methylcyclobutyl)methyl)carbamoyl)tetrahydrofuran-3-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-hydroxycyclohexane-1-carboxylic acid; (1R,4r)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-hydroxycyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-(hydroxymethyl)cyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2S,3R,4R)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-((3-((trifluoromethyl)sulfonyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-fluoro-5-(((2S,3R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1R,4s)-4-(2-cyano-4-fluoro-5-(((2R,3S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.2]octan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; 2'-Fluoro-5'-(((1R,2S,3R,4S)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; 2'-Fluoro-5'-(((1S,2R,3S,4R)-3-((4-fluoro-3-(trifluoromethyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methoxycyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-(methoxymethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((1-cyanocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((3,3,3-trifluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-1,1,1-trifluoropropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(cyclobutylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(cyclopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-1,1,1-trifluoropropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(tert-butylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((1,1,1-trifluoro-2-methylpropan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((R)-1-((trifluoromethyl)sulfonyl)pyrrolidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-1-((trifluoromethyl)sulfonyl)pyrrolidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((S)-1-((trifluoromethyl)sulfonyl)piperidin-3-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-(((1-fluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((2-methoxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((2-hydroxy-2-methylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((3-hydroxy-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-(trifluoromethyl)cyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-(trifluoromethyl)cyclopropyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((R)-3-cyano-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((S)-3-cyano-3-methylbutan-2-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((1-ethylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-((2,2,3,3,3-pentafluoropropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(5-(((1S,2R,3S,4R)-3-(((3,3-difluorocyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-2-fluoro-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1R,2R,3S,4S)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3,3-difluorocyclobutyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid; and (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-((3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid; and pharmaceutically acceptable salts thereof.

[0212] In one embodiment, a pharmaceutical composition is provided comprising 4-(2-fluoro-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0213] In one embodiment, a pharmaceutical composition is provided comprising 4-(2-cyano-4-methoxy-5-((3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0214] In one embodiment, a pharmaceutical composition is provided comprising 4-(2-cyano-4-methoxy-5-((3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0215] In one embodiment, a pharmaceutical composition is provided comprising 4-(2-cyano-5-((3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0216] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0217] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0218] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0219] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0220] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0221] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0222] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0223] In one embodiment, there is provided a pharmaceutical composition comprising (1S,4s)-4-(2-cyano-5-(((1R,2R,3S,4S)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof.

[0224] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid.

[0225] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid.

[0226] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid.

[0227] In one embodiment, a pharmaceutical composition is provided comprising (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid.

[0228] In a further embodiment, there is provided a pharmaceutical composition comprising any one of the Example compounds (named hereinafter in the Experimental Section) or a pharmaceutically acceptable salt thereof.

[0229] In a further embodiment, there is provided a pharmaceutical composition comprising any one of the compounds of the Examples (named hereinafter in the Experimental Section).

[0230] Compounds of formula (I) can be prepared from intermediate compounds (named or shown hereinafter in the experimental section) using the methods described in the experimental section. Those skilled in the art will recognize that other methods can also be used to prepare compounds of formula (I) from such intermediate compounds.

[0231] Thus, in a further embodiment, there is provided any one of the intermediate compounds (named or shown below in the Experimental Section).

[0232] Thus, in a further embodiment, there is provided any one of the intermediate compounds (named or shown in the experimental section below) or a salt thereof.

[0233] Therefore, only a few examples of the above-mentioned embodiments are given below.

[0234] In one embodiment, intermediate 75 or a salt thereof is provided.

[0235] Thus, in this case, (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-(Tert-butoxycarbonyl)-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof is provided.

[0236] In one embodiment, intermediate 68 or a salt thereof is provided.

[0237] Thus, in this case, (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carboxy-4-methylcyclohexyl)oxy)-4-cyano-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof is provided.

[0238] In one embodiment, there is provided (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carboxy-4-methylcyclohexyl)oxy)-4-cyano-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof.

[0239] In one embodiment, intermediate 5 or a salt thereof is provided.

[0240] Thus, in this case, methyl 5-(1,3,6,2-dioxazaborocan-2-yl)-4-fluoro-2-methoxybenzoate or a salt thereof is provided.

[0241] In one embodiment, intermediate 11 or a salt thereof is provided.

[0242] Thus, in this case, naphthalen-1-ylmethyl (1r,4r)-4-hydroxy-1-methylcyclohexane-1-carboxylate or a salt thereof is provided.

[0243] In one embodiment, intermediate 12 or a salt thereof is provided.

[0244] Thus, in this case, methyl 4-fluoro-2-methoxy-5-(((1s,4s)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoate or a salt thereof is provided.

[0245] In one embodiment, intermediate 35 or a salt thereof is provided.

[0246] Thus, in this case, (1R,2S,3R,4S)-3-(4-cyano-5-hydroxy-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide or a salt thereof is provided.

[0247] In one embodiment, there is provided (1S,2S,3R,4R)-3-(4-cyano-5-hydroxy-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide or a salt thereof.

[0248] In one embodiment, there is provided (1R,2S,3R,4S)-3-(4-fluoro-5-hydroxy-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide or a salt thereof.

[0249] In one embodiment, there is provided (1S,2S,3R,4R)-3-(4-fluoro-5-hydroxy-2-methoxybenzamido)-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide or a salt thereof.

[0250] In one embodiment, intermediate 13 or a salt thereof is provided.

[0251] Thus, in this case, 4-fluoro-2-methoxy-5-(((1s,4s)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoic acid or a salt thereof is provided.

[0252] In one embodiment, intermediate 15 or a salt thereof is provided.

[0253] Thus, in this case, methyl (1S,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylate or a salt thereof is provided.

[0254] In one embodiment, there is provided methyl (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylate, or a salt thereof.

[0255] In one embodiment, intermediate 16 or a salt thereof is provided.

[0256] Thus, in this case, (1S,2S,3R,4R)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid or a salt thereof is provided.

[0257] In one embodiment, there is provided (1R,2S,3R,4S)-3-(4-fluoro-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid or a salt thereof.

[0258] In one embodiment, intermediate 584 or a salt thereof is provided.

[0259] Thus, in this case, (1S,2S,3R,4R)-3-(4-cyano-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid or a salt thereof is provided.

[0260] In one embodiment, there is provided (1R,2S,3R,4S)-3-(4-cyano-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid or a salt thereof.

[0261] In one embodiment, intermediate 20 or a salt thereof is provided.

[0262] Thus, in this case, tert-butyl ((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamate or a salt thereof is provided.

[0263] In one embodiment, there is provided tert-butyl ((1R,2R,3S,4S)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]hept-5-en-2-yl)carbamate or a salt thereof.

[0264] In one embodiment, intermediate 21, or a free base or salt thereof, is provided.

[0265] Thus, in this case, (1R,2S,3R,4S)-3-amino-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride or a free base or salt thereof is provided.

[0266] In one embodiment, there is provided (1S,2S,3R,4R)-3-amino-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or a free base or salt thereof.

[0267] In one embodiment, intermediate 22, or a free base or salt thereof, is provided.

[0268] Thus, in this case, (1R,2S,3R,4S)-3-amino-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride or a free base or salt thereof is provided.

[0269] In one embodiment, there is provided (1S,2S,3R,4R)-3-amino-N-((1-methylcyclobutyl)methyl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or a free base or salt thereof.

[0270] In one embodiment, intermediate 224 or a free base or salt thereof is provided.

[0271] Thus, in this case, (1R,2S,3R,4S)-3-amino-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide hydrochloride or a free base or salt thereof is provided.

[0272] In one embodiment, there is provided (1S,2S,3R,4R)-3-amino-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or a free base or salt thereof.

[0273] In one embodiment, intermediate 223 or a free base or salt thereof is provided.

[0274] Thus, in this case, (1R,2S,3R,4S)-3-amino-N-(3-fluorobicyclo[1.1.1]pentan-1-yl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride or a free base or salt thereof is provided.

[0275] In one embodiment, there is provided (1S,2S,3R,4R)-3-amino-N-(3-fluorobicyclo[1.1.1]pentan-1-yl)bicyclo[2.2.1]heptane-2-carboxamide hydrochloride, or a free base or salt thereof.

[0276] In one embodiment, intermediate 73 or a salt thereof is provided.

[0277] Thus, in this case, 5-(((1s,4s)-4-(Tert-butoxycarbonyl)-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzoic acid or a salt thereof is provided.

[0278] In one embodiment, intermediate 69 or a salt thereof is provided.

[0279] Thus, in this case, methyl 4-cyano-2-methoxy-5-(((1s,4s)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoate or a salt thereof is provided.

[0280] In one embodiment, intermediate 70 or a salt thereof is provided.

[0281] Thus, in this case, 4-cyano-2-methoxy-5-(((1s,4s)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzoic acid or a salt thereof is provided.

[0282] In one embodiment, intermediate 71 or a salt thereof is provided.

[0283] Thus, in this case, methyl (1S,2S,3R,4R)-3-(4-cyano-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylate or a salt thereof is provided.

[0284] In one embodiment, there is provided methyl (1R,2S,3R,4S)-3-(4-cyano-2-methoxy-5-(((1s,4S)-4-methyl-4-((naphthalen-1-ylmethoxy)carbonyl)cyclohexyl)oxy)benzamido)bicyclo[2.2.1]hept-5-ene-2-carboxylate, or a salt thereof.

[0285] In one embodiment, intermediate 72 or a salt thereof is provided.

[0286] Thus, in this case, (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(methoxycarbonyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a salt thereof is provided.

[0287] In one embodiment, there is provided (1S,4s)-4-(2-cyano-4-methoxy-5-(((1R,2R,3S,4S)-3-(methoxycarbonyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a salt thereof.

[0288] In one embodiment, intermediate 403 or a salt thereof is provided.

[0289] Thus, in this case, (1R,2S,3R,4S)-3-(5-(((1s,4S)-4-carboxy-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof is provided.

[0290] In one embodiment, there is provided (1S,2S,3R,4R)-3-(5-(((1s,4S)-4-carboxy-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof.

[0291] In one embodiment, intermediate 127 or a salt thereof is provided.

[0292] Thus, in this case, methyl (1R,2S,3R,4S)-3-(5-bromo-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylate or a salt thereof is provided.

[0293] In one embodiment, there is provided methyl (1S,2S,3R,4R)-3-(5-bromo-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylate or a salt thereof.

[0294] In one embodiment, intermediate 128 or a salt thereof is provided.

[0295] Thus, in this case, (1R,2S,3R,4S)-3-(5-bromo-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof is provided.

[0296] In one embodiment, there is provided (1S,2S,3R,4R)-3-(5-bromo-4-fluoro-2-methoxybenzamido)bicyclo[2.2.1]heptane-2-carboxylic acid or a salt thereof.

[0297] In one embodiment, intermediate 136 or a salt thereof is provided.

[0298] Thus, in this case, benzyl 5-(((1s,4s)-4-(tert-butoxycarbonyl)-4-methylcyclohexyl)oxy)-4-fluoro-2-methoxybenzoate or a salt thereof is provided.

[0299] In one embodiment, intermediate 521 or a salt thereof is provided.

[0300] Thus, in this case, (1s,4s)-4-(2-fluoro-4-methoxy-5-(methoxycarbonyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a salt thereof is provided.

[0301] In one embodiment, there is provided a process for preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof, using an intermediate compound (described herein or named or shown in the experimental section below) or a salt thereof.

[0302] In one embodiment, there is provided a process for preparing (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof, using an intermediate compound (described herein or named or shown in the Experimental section below) or a salt thereof.

[0303] In one embodiment, there is provided a process for preparing (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof, using an intermediate compound (described herein or named or shown in the Experimental section below) or a salt thereof.

[0304] In one embodiment, there is provided a process for preparing (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(neopentylcarbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof, using an intermediate compound (described herein or named or shown in the Experimental section below) or a salt thereof.

[0305] In one embodiment, there is provided a process for preparing (1S,4s)-4-(2-cyano-5-(((1S,2R,3S,4R)-3-((3-fluorobicyclo[1.1.1]pentan-1-yl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt thereof, using an intermediate compound (described herein or named or shown in the Experimental section below) or a salt thereof.

[0306] Terms not specifically defined herein should be understood to have the meaning that would be ascribed to them by one of ordinary skill in the art in light of this disclosure and context. However, as used herein, unless otherwise indicated, the following terms have the indicated meanings and follow the following conventions. In the groups defined below, the number of carbon atoms is often specified before the group. For example, C 1-4 Alkyl means an alkyl group or radical having 1 to 4 carbon atoms.

[0307] "Alkyl" means a saturated aliphatic branched or straight chain hydrocarbon group having the specified number of carbon atoms. For example, C 1-4 Alkyl means a group having 1 to 4 carbon atoms in a straight or branched chain, for example, -CH2CH2CH2CH3 or -CH2CH(CH3)2. An "alkylene" is a divalent alkyl group.

[0308] "Alkoxy" means an alkyl group attached through an oxygen linking atom. For example, C 1-3 Alkoxy includes methoxy, ethoxy and propoxy.

[0309] "Aryl" means an aromatic monocyclic or polycyclic hydrocarbon ring system having the specified number of carbon atoms. For example, C 6-10 Aryl includes groups such as phenyl and naphthalenyl. An "arylene" is a divalent aryl group.

[0310] "Cycloalkyl" means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated aliphatic hydrocarbon group having the specified number of carbon atoms. For example, cycloalkyl includes groups such as cyclohexyl, adamantyl, spiro[3.3]heptanyl, bicyclo[2.2.1]heptanyl, and decahydronaphthalenyl. As a further example, monocyclic C 3-6 Cycloalkyl means a group having 3 to 6 carbon atoms arranged in a monocyclic ring, for example, cyclopropyl and cyclohexyl. A "cycloalkylene" is a divalent cycloalkyl group.

[0311] "Cycloalkoxy" means a cycloalkyl group attached through an oxygen linking atom. For example, C 3-4 Cycloalkoxy includes cyclopropoxy and cyclobutoxy.

[0312] "Cycloalkenyl" refers to a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated aliphatic hydrocarbon group having the specified number of carbon atoms. For example, cycloalkenyl includes groups such as cyclohexenyl, spiro[4.4]non-2-enyl, bicyclo[2.2.1]hept-2-enyl, and 1,2,3,4,4a,5,8,8a-octahydronaphthalenyl. Further examples include monocyclic C 5-6 Cycloalkenyl means a group having 3 to 6 carbon atoms arranged in a monocyclic ring, for example, cyclopentenyl and cyclohexenyl. A "cycloalkenylene" is a divalent cycloalkenyl group.

[0313] "Heteroaryl" means an aromatic monocyclic or multicyclic ring system containing carbon atoms and the specified number of heteroatoms (e.g., O, N, or S) in the ring structure, with the total number of atoms specified in the ring structure. For example, a 5- to 10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur includes groups such as indolyl, pyridyl, thiazolyl, and oxazolyl. A "heteroarylene" is a divalent heteroaryl group.

[0314] "Heterocycloalkyl" means a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic saturated group that contains carbon atoms and the specified number of heteroatoms (e.g., O, N, or S) in its ring structure, with the total number of atoms specified in the ring structure. For example, a 4- to 8-membered heterocycloalkyl having 1-3 heteroatoms independently selected from oxygen, nitrogen, and sulfur includes groups such as pyrrolidinyl, oxetanyl, 2-oxa-6-azaspiro[3.3]heptanyl, hexahydro-2H-thieno[2,3-c]pyrrolyl, and 7-oxabicyclo[2.2.1]heptanyl. A "heterocycloalkylene" is a divalent heterocycloalkyl group.

[0315] "Heterocycloalkenyl" refers to a monocyclic, bicyclic, polycyclic, fused, bridged, or spirocyclic unsaturated group containing carbon atoms and the specified number of heteroatoms (e.g., O, N, or S) in the ring structure, with the total number of carbon atoms and heteroatoms specified in the ring structure. For example, a 4-8-membered heterocycloalkenyl having 1-3 heteroatoms independently selected from oxygen, nitrogen, and sulfur includes groups such as 2,5-dihydro-1H-pyrrolyl, 7-oxabicyclo[2.2.1]hept-2-enyl, and 4,5,6,6a-tetrahydro-2H-thieno[2,3-c]pyrrol-3-yl. A "heterocycloalkenylene" is a divalent heterocycloalkenyl group.

[0316] "Heteroalkyl" means an alkyl group, as defined herein, in which one or more of the constituent carbon atoms has been replaced by nitrogen, oxygen, or sulfur. The specified number of members in a heteroalkyl group refers to the total number of carbon atoms and heteroatoms in the chain. For example, -CHOCHCH and -CHN(CH)CHCH. As a further example, a four-membered heteroalkyl group containing one heteroatom selected from oxygen and sulfur includes groups such as -CHOCHCH, -SCH(CH), and -CH(CH)CHOH. A "heteroalkylene" is a divalent heteroalkyl group.

[0317] "Halogen" means a fluorine (fluoro), chlorine (chloro), bromine (bromo) or iodine (iodo) group.

[0318] The chemical names of the compounds described herein were generated using ChemDraw® Professional version 19.0.0.22 from PerkinElmer®. One of ordinary skill in the art will appreciate that different chemical naming software may generate different chemical names for a particular compound. When a compound described herein is shown in chemical name form and as a formula, in the event of any discrepancy, the formula shall prevail.

[0319] In substituents such as --OH and --CN, the "-" indicates the point of attachment of the substituent to the rest of the molecule.

[0320] [ka] In fragments such as [ka] specifies the point of attachment of the fragment to the rest of the molecule.

[0321] The term "pharmaceutically acceptable" is used to specify that an entity (e.g., a salt, a dosage form, or an excipient) is suitable for use in patients. An exemplary list of pharmaceutically acceptable salts can be found in Handbook of Pharmaceutical Salts: Properties, Selection and Use, PH Stahl and CG Wermuth, editors, Weinheim / Zurich: Wiley-VCH / VHCA, 2002. Suitable pharmaceutically acceptable salts of the compound of formula (I) are, for example, acid addition salts or base addition salts. Acid addition salts of the compound of formula (I) can be formed by contacting the compound with a suitable inorganic or organic acid under conditions known to those skilled in the art. Acid addition salts can be formed, for example, using an inorganic acid selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, and phosphoric acid. Acid addition salts can also be formed using organic acids selected from the group consisting of trifluoroacetic acid, citric acid, maleic acid, oxalic acid, acetic acid, formic acid, benzoic acid, fumaric acid, succinic acid, tartaric acid, lactic acid, pyruvic acid, methanesulfonic acid, benzenesulfonic acid, and para-toluenesulfonic acid.

[0322] Thus, in one embodiment, there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable salt is a salt of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, trifluoroacetic acid, citric acid, maleic acid, oxalic acid, acetic acid, formic acid, benzoic acid, fumaric acid, succinic acid, tartaric acid, lactic acid, pyruvic acid, methanesulfonic acid, benzenesulfonic acid or para-toluenesulfonic acid.

[0323] The compounds described herein may form base addition salts. Base addition salts of compounds of formula (I) can be formed by contacting the compound with a suitable inorganic acid or organic base under conditions known to those skilled in the art. For example, alkali metal (e.g., sodium, potassium, or lithium) or alkaline earth metal (e.g., calcium) salts may be prepared by treating the compound in an aqueous medium with an alkali metal or alkaline earth metal hydroxide or alkoxide (e.g., ethoxide or methoxide) or a suitable basic organic amine (e.g., choline or meglumine). Thus, in one embodiment, a compound of formula (I) or a pharmaceutically acceptable salt thereof is provided, wherein the pharmaceutically acceptable salt is a sodium, potassium, lithium, calcium, choline, or meglumine salt.

[0324] In one embodiment, there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof:

[0325] In one embodiment, there is provided a compound according to formula (I):

[0326] In one embodiment, there is provided a pharmaceutically acceptable salt of a compound of formula (I).

[0327] The compounds and salts described herein may exist in solvated and unsolvated forms. For example, a solvated form may be a hydrated form, such as a hemihydrate, monohydrate, dihydrate, trihydrate, or an equivalent thereof. All such solvated and unsolvated forms of the compounds of formula (I) are encompassed herein.

[0328] The atoms of the compounds and salts described herein may exist in their isotopes. All compounds of formula (I) in which an atom is replaced by one or more of its isotopes (e.g., compounds in which one or more carbon atoms are 11 C or 13 C carbon isotope or one or more hydrogen atoms are 2 H or 3H isotope) are included herein.

[0329] The compounds of the present application may exist in one or more geometric, optical, enantiomeric, and diastereomeric forms, including (but not limited to) cis and trans, E and Z, and R, S and meso forms. Unless otherwise stated, reference to a particular compound includes all such isomeric forms, including racemates and other mixtures. Where appropriate, such isomers can be separated from their mixtures by the application or adaptation of known methods (e.g., chromatographic and recrystallization techniques). Where appropriate, such isomers can be prepared by the application or adaptation of known methods.

[0330] The compounds of formula (I) may contain one or more chiral centers. Unless a structure or chemical name herein indicates chirality, the structure or name is intended to encompass any single stereoisomer and any mixture of stereoisomers (e.g., racemates) corresponding to the structure or name. The structures herein are represented by solid and dashed wedges (i.e., [ka] When a bond is depicted as a chiral center, the solid and dashed wedges are intended to indicate the absolute configuration of the chiral center unless an "or" or "&" chiral flag is present at the chiral center. A group of related chiral flags is designated by the same integer, e.g., "or1", "&1", "or2", "&2", etc. One of ordinary skill in the art will understand the meaning of the chiral flag at the chiral center. For example, the structure [ka] indicates that the compound is a single stereoisomer with a defined absolute configuration. [ka] indicates that the compound is a single stereoisomer with a defined relative configuration at the flagged chiral center, but the absolute configuration at the flagged chiral center is unknown. [ka] indicates that the compound is a mixture of stereoisomers with defined relative configurations at the flagged chiral centers.

[0331] It is well known in the art how such optically active forms can be separated. For example, a single stereoisomer can be obtained by isolation from a mixture of isomers (e.g., a racemate) using, for example, chiral chromatographic separation. In other embodiments, a single stereoisomer can be obtained, for example, by direct synthesis from chiral starting materials.

[0332] According to one embodiment, there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, which is a single enantiomer in enantiomeric excess (% ee) of ≥ 95%, ≥ 98% or ≥ 99%. Advantageously, the single enantiomer is present in enantiomeric excess of ≥ 99%.

[0333] According to one embodiment, there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, which is a single enantiomer in enantiomeric excess (% ee) in the range of 95 to 100%.

[0334] According to one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, in a single enantiomer in enantiomeric excess (% ee) of ≥ 95%, ≥ 98%, or ≥ 99%, together with a pharmaceutically acceptable diluent or carrier. Advantageously, the single enantiomer is present in enantiomeric excess of ≥ 99%.

[0335] According to one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, which is a single enantiomer in enantiomeric excess (% ee) in the range of 95 to 100%, together with a pharmaceutically acceptable diluent or carrier.

[0336] The compounds of the present application may exist in one or more tautomeric forms, including, but not limited to, the keto and enol forms. A reference to a particular compound includes all tautomeric forms, including mixtures thereof. Thus, a structure shown herein as one tautomer is intended to include the other tautomers as well.

[0337] The compounds of formula (I) can be administered in the form of prodrugs. Prodrugs are compounds that are broken down in the human or animal body to release the compounds of formula (I). Such pharmaceutically acceptable prodrugs of compounds of formula (I) also form an embodiment. Various forms of prodrugs are known in the art. For example, a) Design of Pro-drugs, edited by H. Bundgaard, (Elsevier, 1985); b)A Textbook of Drug Design and Development, edited by Krogsgaard-Larsen and H. Bundgaard, Chapter 5 “Design and Application of Pro-drugs”, by H. Bundgaard p. 113-191 (1991); c) H. Bundgaard, Advanced Drug Delivery Reviews, 8, 1-38 (1992); d) H. Bundgaard, et al., Journal of Pharmaceutical Sciences, 77, 285 (1988) and e) N. Kakeya, et al., Chem. Pharm. Bull., 32, 692 (1984) Please refer to.

[0338] In one embodiment, there is provided a prodrug of a compound of formula (I) as defined herein or a pharmaceutically acceptable salt thereof.

[0339] In one embodiment, there is provided a prodrug of a compound of formula (I) as defined herein or a pharmaceutically acceptable salt thereof, wherein said prodrug is a compound of formula (I) as defined herein, wherein R 1 -COO(C 1-4 A compound of formula (I) as defined herein except that:

[0340] In one embodiment, there is provided an N-oxide of a compound of formula (I) as defined herein, or a prodrug or pharmaceutically acceptable salt thereof.

[0341] As a result of modulation of RXFP1, compounds of formula (I) and their pharmaceutically acceptable salts are expected to be useful in therapy.

[0342] The term "treatment" is intended to have its ordinary meaning of dealing with a disease or condition in order to completely or partially alleviate one, some or all of its symptoms or to correct or compensate for an underlying pathology. The term "treatment" also includes "prophylaxis" unless otherwise specified. The terms "therapeutic" and "therapeutically" should be interpreted accordingly.

[0343] The term "prevention" is intended to have its ordinary meaning and includes primary prevention, to prevent the onset of a disease or condition, and secondary prevention, where the disease or condition has already occurred and the patient is protected, either temporarily or permanently, from worsening or exacerbating the disease or condition or from developing new symptoms associated with the disease or condition.

[0344] The term "treatment" is used synonymously with "therapy." Similarly, the term "treating" can be considered as "applying therapy," where "treatment" is as defined herein.

[0345] Thus, the compounds or pharmaceutical compositions described herein can be used therapeutically, for example, to treat a disease or disorder. Also provided is a method of treating a disease or disorder, comprising administering a therapeutically effective amount of a compound described herein to a subject or patient in need thereof.

[0346] It will be appreciated that the compounds described herein can be used in the treatment of cardiovascular disease, for example, in the treatment of heart failure.

[0347] As used herein, the term "heart failure" includes acute heart failure, chronic heart failure (CHF), and acute decompensated heart failure (ADHF). The term "heart failure" may also include more specific diagnoses, such as heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction, or heart failure with reduced ejection fraction (HFrEF).

[0348] The compounds described herein can also be used to treat kidney disease (including chronic kidney disease), acute kidney injury, lung disease, and fibrotic disorders, such as fibrotic disorders of the kidney, heart, lung, and liver, as well as wound healing (Sherwood OD (2004) Endocrine Reviews 25(2): 205-234). The compounds described herein can also be used to reverse insulin resistance in diabetic patients (Bonner JS et al. (2013) Diabetes 62(9):3251-3260). The compounds described herein can also be used to treat various forms of pulmonary hypertension. The compounds described herein can also be used to treat disorders that are a result of or cause arteriosclerosis, decreased arterial elasticity, decreased arterial compliance, and decreased distensibility, including hypertension, kidney disease, peripheral arterial disease, carotid and cerebrovascular disease (i.e., stroke and dementia), diabetes, microvascular disease resulting in peripheral organ damage, coronary artery disease, and heart failure. The compounds described herein can also be used to treat pre-eclampsia.

[0349] In one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in therapy.

[0350] In one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with mildly reduced ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury.

[0351] In one embodiment, there is provided a pharmaceutical composition comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of heart failure.

[0352] In one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of heart failure with preserved ejection fraction, heart failure with mildly reduced ejection fraction and / or heart failure with reduced ejection fraction.

[0353] In one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of chronic kidney disease and / or acute kidney injury.

[0354] In one embodiment, there is provided a use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with mildly reduced ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury.

[0355] The term "therapeutically effective amount" refers to an amount of a compound of Formula (I) described in any of the embodiments herein that is effective to provide "therapy" in a subject or to "treat" a disease or condition in a subject. A therapeutically effective amount can produce any observable or measurable change in a subject, as described above in the definitions of "therapy," "treatment," and "prevention." As will be recognized by those skilled in the art, the effective amount may vary depending on the route of administration, the use of excipients, and the use in combination with other drugs. For example, when a combination therapy is used, the amount of a compound of Formula (I) or a pharmaceutically acceptable salt described herein and the amount of another pharmaceutically active agent, when combined, are jointly effective to treat the targeted disorder or condition in a subject. In this context, the combined amount is a "therapeutically effective amount" if, when used in combination, they are sufficient to reduce the symptoms of a disease or condition that responds to modulation and / or agonism of RXFP1 as described above. Typically, such amounts can be determined by one of ordinary skill in the art, for example, by starting from the dosage ranges described herein for compounds of Formula (I) or pharmaceutically acceptable salts thereof and approved or otherwise published dosage ranges for other pharmaceutically active compounds.

[0356] A "subject" includes, for example, a mammal, such as a human.

[0357] In one embodiment, a method is provided for treating a disease or condition selected from the group consisting of heart failure, heart failure with preserved ejection fraction, heart failure with mildly reduced ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease, and acute kidney injury.

[0358] The compounds of formula (I) and their pharmaceutically acceptable salts may be administered as pharmaceutical compositions containing one or more pharmaceutically acceptable excipients.

[0359] Thus, in one embodiment, there is provided a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

[0360] The excipients selected for inclusion in a particular composition will depend on factors such as the mode of administration and form of the composition provided. Suitable pharmaceutically acceptable excipients are well known to those skilled in the art and are described, for example, in Handbook of Pharmaceutical Excipients, Sixth Edition, Pharmaceutical Press, edited by Rowe, Ray C; Sheskey, Paul J; Quinn, Marian. Pharmaceutically acceptable excipients can function, for example, as adjuvants, diluents, carriers, stabilizers, flavorings, colorings, fillers, binders, disintegrants, lubricants, glidants, thickeners, and coating agents. As will be understood by those skilled in the art, a particular pharmaceutically acceptable excipient may perform more than one function and may perform alternative functions depending on how much of the excipient is present in the composition and what other excipients are present in the composition.

[0361] The pharmaceutical composition may be in a suitable form for oral use (e.g., as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixirs), topical use (e.g., as creams, ointments, gels, or aqueous or oily solutions or suspensions), administration by inhalation (e.g., as a micronized powder or liquid aerosol), administration by insufflation (e.g., as a micronized powder), or parenteral administration (e.g., as a sterile aqueous or oily solution for intravenous, subcutaneous, intramuscular, or intramuscular administration) or as a suppository for rectal administration. The composition may be obtained by conventional methods well known in the art. Compositions intended for oral use may contain additional ingredients, such as one or more colorants, sweeteners, flavorings, and / or preservatives.

[0362] The compound represented by formula (I) is usually administered in an amount of 2.5 to 5000 mg / m 2 A single dose of about 0.05 to 100 mg / kg of the subject's body area will be administered to the subject. This will generally provide a therapeutically effective dose. A unit dosage form, such as a tablet or capsule, will generally contain, for example, 0.1 to 400 mg of active ingredient. The daily dose will necessarily vary depending on the host being treated, the particular route of administration, any co-administered therapy, and the severity of the disease or condition being treated.

[0363] The pharmaceutical compositions described herein comprise a compound of formula (I) or a pharmaceutically acceptable salt thereof and are therefore expected to be useful in therapy.

[0364] Thus, in one embodiment, there is provided a pharmaceutical composition for use in treatment, the pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

[0365] In formulating a pharmaceutical composition, it is important that the drug substance be in a form that allows it to be conveniently handled and processed. This is important not only from the standpoint of obtaining a commercially viable manufacturing process, but also from the standpoint of the subsequent manufacture of pharmaceutical formulations (e.g., oral dosage forms, e.g., tablets) containing the active compound.

[0366] The different physical properties of crystalline forms relative to each other and relative to the amorphous state can greatly affect the chemical and pharmaceutical processing of compounds, especially when the compounds are produced or used on an industrial scale.

[0367] Furthermore, it is important in the manufacture of oral drug compositions to provide a reliable and reproducible plasma concentration profile of the drug after administration to a patient. Patient-to-patient variability in the absorption profile of a drug in the stomach, intestine, or bloodstream can affect the safety and efficacy of the drug.

[0368] The chemical stability, solid-state stability, and "shelf-life" of the active ingredient are also very important factors: drug substances and compositions containing them should be able to be effectively stored for a significant period of time without exhibiting significant changes in the physicochemical properties of the active ingredient (e.g., its chemical composition, density, hygroscopicity, and solubility).

[0369] Additionally, it is important to be able to provide the drug in as chemically pure a form as possible.

[0370] Amorphous materials can present problems in this regard: for example, such materials are typically difficult to handle and formulate, offer unreliable solubility, and are often found to be unstable and chemically impure.

[0371] Those skilled in the art will appreciate that if the drug could be readily obtained in a stable crystalline form, the above problems could be solved.

[0372] Therefore, in the manufacture of commercially viable and pharmaceutically acceptable drug compositions, it is important to provide the drug in a crystalline, stable form whenever possible.

[0373] However, it should be noted that this goal is not always achievable. Indeed, it is typically not possible to predict the crystallization behavior of a compound, either by itself or in the form of a salt, from its molecular structure alone. This can only be determined empirically.

[0374] In one embodiment, certain compounds and their salts can be prepared in crystalline form. These crystalline forms may be characterized as specific polymorphic forms. When an embodiment is described as relating to a crystalline form, the degree of crystallinity is advantageously greater than about 60%, more advantageously greater than about 80%, preferably greater than about 90%, and more preferably greater than about 95%. Most preferably, the degree of crystallinity is greater than about 98%.

[0375] Certain solid forms described herein provide X-ray powder diffraction patterns substantially similar to those shown in the figures, with various 2-theta values ​​described herein. It is understood that the 2-theta values ​​of X-ray powder diffraction patterns may vary slightly from machine to machine or sample to sample, and therefore the values ​​quoted should not be construed as absolute values.

[0376] It is known that an X-ray powder diffraction pattern may have one or more measurement errors depending on the measurement conditions (e.g., the equipment or machine used). In particular, it is generally known that the intensities of an X-ray powder diffraction pattern may vary depending on the measurement conditions. Therefore, the solid forms described herein are not limited to crystals that provide the same X-ray powder diffraction pattern as the one shown in the figure, and it should be understood that any crystal that provides substantially the same X-ray powder diffraction pattern as the one shown in the figure falls within the scope of the embodiments described herein. Those skilled in the art of X-ray powder diffraction can judge the substantial identity of X-ray powder diffraction patterns.

[0377] Those skilled in the art of X-ray powder diffraction will recognize that the relative intensities of peaks can be affected, for example, by particles larger than 30 μm in size and non-unitary aspect ratios, which can affect the analysis of the sample. Those skilled in the art will also recognize that the position of reflections can be affected by the exact height at which the sample is positioned within the diffractometer and the zero calibration of the diffractometer. The surface flatness of the sample can also have a small effect. Therefore, the diffraction pattern data presented should not be considered absolute (Jenkins, R & Snyder, RL "Introduction to X-Ray Powder Diffractometry" John Wiley & Sons 1996; Bunn, CW (1948), Chemical Crystallography, Clarendon Press, London; Klug, HP & Alexander, LE (1974), X-Ray Diffraction Procedures). Peak intensities are designated herein as vs (very strong), s (strong), m (moderate), and w (weak), corresponding to % relative intensities (based on the most intense peak) of 25-100%, 10-25%, 3-10%, and 1-3%, respectively. Relative intensities are derived from diffractograms measured with a fixed slit.

[0378] Typically, the measurement error of diffraction angles in X-ray powder diffractograms is about 5% or less, specifically ±0.5° 2-theta, and this degree of measurement error should be taken into account when reading the data set forth herein and considering the X-ray powder diffraction patterns in the figures herein. Furthermore, it should be understood that intensities may vary depending on experimental conditions and sample preparation (preferred orientation).

[0379] X-ray powder diffraction analysis was carried out according to standard methods that can be found, for example, in Kitaigorodsky, AI (1973), Molecular Crystals and Molecules, Academic Press, New York; Bunn, CW (1948), Chemical Crystallography, Clarendon Press, London, or Klug, HP & Alexander, LE (1974), X-ray Diffraction Procedures, John Wiley & Sons, New York.

[0380] X-ray powder diffraction data was measured using corundum as an internal standard. X-ray powder diffraction (herein referred to as XRPD) patterns were determined by mounting the sample on a silicon single crystal in a zero background holder and spreading the sample into a thin layer.

[0381] X-ray powder diffraction was performed using a Rigaku Miniflex 600 equipped with a D / Tex detector (X-ray wavelength 1.5418 Å, nickel filter CuK) α Theta-2theta scans were recorded in both the axial and uniaxial scans using a 40 kV, 15 mA (radiation). Automatic variable divergence and anti-scatter slits were used, and the sample was rotated at 80 revolutions per minute during the measurements. The sample was scanned from 2.4 to 50° 2theta using a step width and scan rate of 0.01° and 1° / min, respectively.

[0382] Herein, (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid (Example 1) is also referred to as "Compound X." Subsequently, several useful crystalline polymorphs were prepared using the conditions described in Example 1. In all embodiments of the solid forms described herein, the peaks in the X-ray diffraction pattern are CuK αIt is measured using radiation.

[0383] Thus, in one embodiment, there is provided a pharmaceutical composition comprising polymorphic Form A of Compound X. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 7.5, 10.7, 12.8, 14.5 and 15.8 o The present invention can be characterized by providing at least one of the following:

[0384] Polymorphic Form A of Compound X is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0385] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 7.5(s), 10.3(m), 10.7(s), 12.8(s), 14.5(vs), 15.3(s), 15.8(s), 17.5(m), 19.6(s), and 21.3(s).

[0386] In one embodiment, 2 theta = 7.5, 10.7, 12.8, 14.5 and 15.8 o Pharmaceutical compositions are provided that include polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks in close proximity.

[0387] In one embodiment, 2 theta = 7.5, 10.3, 10.7, 12.8, 14.5, 15.3, 15.8, 17.5, 19.6 and 21.3 o Pharmaceutical compositions are provided that include polymorphic Form A of Compound X, which has an X-ray powder diffraction pattern with specific peaks around it.

[0388] In one embodiment, a pharmaceutical composition is provided comprising Polymorph A of Compound X, having an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern depicted in FIG.

[0389] In one embodiment, 2 theta = 7.5, 10.7, 12.8, 14.5 and 15.8 oand wherein said values ​​can be ±0.2° 2-theta.

[0390] In one embodiment, 2 theta = 7.5, 10.3, 10.7, 12.8, 14.5, 15.3, 15.8, 17.5, 19.6 and 21.3 o and wherein said values ​​may be within ±0.2° 2-theta.

[0391] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form B of Compound X. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 6.9, 8.2, 9.2, 11.5 and 15.9 o The present invention can be characterized by providing at least one of the following:

[0392] Polymorphic Form B of Compound X is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0393] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 6.9 (vs), 8.2 (vs), 9.2 (vs), 9.6 (s), 11.5 (s), 12.3 (vs), 13.0 (m), 15.9 (vs), 16.3 (s), and 23.1 (vs).

[0394] In one embodiment, 2 theta = 6.9, 8.2, 9.2, 11.5 and 15.9 o Pharmaceutical compositions are provided that include polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks in close proximity.

[0395] In one embodiment, 2 theta = 6.9, 8.2, 9.2, 9.6, 11.5, 12.3, 13.0, 15.9, 16.3 and 23.1 oPharmaceutical compositions are provided that include polymorphic Form B of Compound X, which has an X-ray powder diffraction pattern with specific peaks around

[0396] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form B of Compound X, having an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern depicted in FIG.

[0397] In one embodiment, 2 theta = 6.9, 8.2, 9.2, 11.5 and 15.9 o and wherein said values ​​can be ±0.2° 2-theta.

[0398] In one embodiment, 2 theta = 6.9, 8.2, 9.2, 9.6, 11.5, 12.3, 13.0, 15.9, 16.3 and 23.1 o and wherein said values ​​may be within ±0.2° 2-theta.

[0399] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form D of Compound X. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 7.0, 7.7, 14.0, 16.1 and 16.9 o The present invention can be characterized by providing at least one of the following:

[0400] Polymorphic Form D of Compound X is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0401] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 7.0 (m), 7.7 (vs), 14.0 (vs), 15.0 (m), 16.1 (vs), 16.9 (vs), 18.3 (s), 19.4 (vs), 20.2 (s), and 20.9 (vs).

[0402] In one embodiment, 2 theta = 7.0, 7.7, 14.0, 16.1 and 16.9 o Pharmaceutical compositions are provided that include polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks in close proximity.

[0403] In one embodiment, 2 theta = 7.0, 7.7, 14.0, 15.0, 16.1, 16.9, 18.3, 19.4, 20.2 and 20.9 o Pharmaceutical compositions are provided that include polymorphic Form D of Compound X, which has an X-ray powder diffraction pattern with specific peaks around

[0404] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form D of Compound X, having an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern depicted in FIG.

[0405] In one embodiment, 2 theta = 7.0, 7.7, 14.0, 16.1 and 16.9 o and wherein said values ​​can be ±0.2° 2-theta.

[0406] In one embodiment, 2 theta = 7.0, 7.7, 14.0, 15.0, 16.1, 16.9, 18.3, 19.4, 20.2 and 20.9 o and wherein said values ​​may be within ±0.2° 2-theta.

[0407] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form E of Compound X. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 6.1, 7.5, 8.2, 14.5 and 15.6 o The present invention can be characterized by providing at least one of the following:

[0408] Polymorphic Form E of Compound X is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0409] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 6.1 (vs), 7.5 (m), 8.2 (m), 9.4 (m), 10.3 (m), 10.7 (m), 14.5 (s), 15.6 (vs), 16.4 (s), and 20.1 (s).

[0410] In one embodiment, 2 theta = 6.1, 7.5, 8.2, 14.5 and 15.6 o Pharmaceutical compositions are provided that include polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with at least five specific peaks in the vicinity.

[0411] In one embodiment, 2 theta = 6.1, 7.5, 8.2, 9.4, 10.3, 10.7, 14.5, 15.6, 16.4 and 20.1 o Pharmaceutical compositions are provided that include polymorphic Form E of Compound X, which has an X-ray powder diffraction pattern with specific peaks around

[0412] In one embodiment, a pharmaceutical composition is provided comprising polymorphic Form E of Compound X, having an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern depicted in FIG.

[0413] In one embodiment, 2 theta = 6.1, 7.5, 8.2, 14.5 and 15.6 o and wherein the X-ray powder diffraction pattern has at least five specific peaks at 100° C., 100° F., 100° C ...

[0414] In one embodiment, 2 theta = 6.1, 7.5, 8.2, 9.4, 10.3, 10.7, 14.5, 15.6, 16.4 and 20.1 o and wherein said values ​​may be within ±0.2° 2-theta.

[0415] Herein, (1S,4s)-4-(2-cyano-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid (Example 592) is also referred to as "Compound Y." Subsequently, several useful crystalline polymorphs were prepared using the conditions described in Example 592. In all embodiments of the solid forms described herein, the peaks in the X-ray diffraction pattern are CuK α It is measured using radiation.

[0416] Thus, in one embodiment, there is provided a pharmaceutical composition comprising polymorphic Form A of Compound Y. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 6.7, 10.5, 13.5, 15.2 and 18.6 o The present invention can be characterized by providing at least one of the following:

[0417] Polymorphic Form A of Compound Y is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0418] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 6.7 (m), 10.5 (vs), 11.8 (m), 13.5 (s), 14.1 (m), 15.2 (s), 16.0 (m), 16.8 (s), 18.6 (vs), and 19.8 (vs).

[0419] In one embodiment, 2 theta = 6.7, 10.5, 13.5, 15.2 and 18.6 o Pharmaceutical compositions are provided that include polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with at least five specific peaks in the vicinity.

[0420] In one embodiment, 2 theta = 6.7, 10.5, 11.8, 13.5, 14.1, 15.2, 16.0, 16.8, 18.6 and 19.8o Pharmaceutical compositions are provided that include polymorphic Form A of Compound Y, which has an X-ray powder diffraction pattern with specific peaks around

[0421] In one embodiment, a pharmaceutical composition is provided comprising Polymorph A of Compound Y, having an X-ray powder diffraction pattern substantially the same as the X-ray powder diffraction pattern depicted in FIG.

[0422] In one embodiment, 2 theta = 6.7, 10.5, 13.5, 15.2 and 18.6 o and wherein said values ​​can be ±0.2° 2-theta.

[0423] In one embodiment, 2 theta = 6.7, 10.5, 11.8, 13.5, 14.1, 15.2, 16.0, 16.8, 18.6 and 19.8 o and wherein said values ​​can be ±0.2° 2-theta.

[0424] Thus, in one embodiment, there is provided a pharmaceutical composition comprising polymorphic Form B of Compound Y. This polymorph is CuK α The following 2θ values ​​were measured using radiation: 6.0, 7.6, 8.6, 19.0 and 20.2 o The present invention can be characterized by providing at least one of the following:

[0425] Polymorphic Form B of Compound Y is characterized by providing an X-ray powder diffraction pattern substantially as shown in FIG.

[0426] The ten most prominent X-ray powder diffraction peaks [angle two theta (2θ), intensity] for this polymorph are 6.0 (m), 7.6 (m)...

Claims

1. (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid: 【Chemistry 1】 A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof.

2. The compound is (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid: 【Chemistry 2】 The pharmaceutical composition according to claim 1.

3. A pharmaceutically acceptable salt of the compound is a pharmaceutically acceptable salt of (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid: 【Transformation 3】 The pharmaceutical composition according to claim 1.

4. The following formula (1S,4s)-4-(2-fluoro-4-methoxy-5-(((1S,2R,3S,4R)-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid: 【Chemistry 4】 A pharmaceutical composition containing a compound crystal.

5. The crystal has an X-ray powder diffraction pattern (CuK) having at least five specific peaks at 2 theta = 7.5, 10.7, 12.8, 14.5 and 15.8°. α The pharmaceutical composition according to claim 4, wherein it has radiation, and the value is ±0.2° 2-theta.

6. The aforementioned crystal exhibits the same X-ray powder diffraction pattern as the one shown in Figure 1 (CuK α The pharmaceutical composition according to claim 4, having (radiation).

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