Improved dual specificity polypeptide molecule

Abstract

To provide improved bispecific molecules capable of targeting peptide-MHC-complexes, that can be easily produced, display high stability and also provide high potency when binding to the respective antigen epitopes.SOLUTION: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells that specifically bind to a surface antigen of the cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.SELECTED DRAWING: None

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