Photochromic soft contact lens with cosmetic considerations and efficacy precautions

Abstract

To improve cosmetic aspects of a photochromic ophthalmic lens.SOLUTION: A photochromic ophthalmic lens may comprise a main body, which comprises an optical zone and a peripheral zone that is disposed adjacently to the optical zone, where one or more of the optical and peripheral zones comprises a photochromic dye, where the ophthalmic lens has a thickness profile that is configured based on cosmetic appearance associated with a target level of transmission (% T), and where at least a portion of the thickness profile is the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target prescription.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] (CROSS-REFERENCE TO RELATED APPLICATIONS) This application claims priority to U.S. Patent Application No. 16 / 406,454, filed May 8, 2019, which is incorporated herein by reference in its entirety. [Background technology]

[0002] Although soft contact lenses are primarily designed to correct vision defects, other aspects of the lens are also considered during the design process, such as handling (e.g., for lens insertion and removal), comfort, fit, or any other aspect that required consideration during the design process. Standard cosmetic lenses, such as tinted lenses, provide cosmetic enhancement of the corneal area. Printed patterns and / or colored areas can have potential adverse effects on the optical performance of the lens. Therefore, conventional printed patterns and / or colored areas are limited and do not extend to or cover the sclera and / or pupil of the eye. Summary of the Invention [Problem to be solved by the invention]

[0003] In lenses with large power corrections, whether the lens is edge-to-edge photochromic or center-only photochromic, significant variations in thickness exist within its optical zone. High plus lenses will have thick central optical zones, while high minus lenses will have thick peripheral optical zones. These significant variations in thickness within the optical zone will also affect the cosmetic aspects of the lens.

[0004] Improvement is needed. [Means for solving the problem]

[0005] In the present disclosure, soft contact lenses may include or be formed from a monomer mixture containing a photochromic dye material. When the photochromic dye is thoroughly mixed with the lens material monomer, the photochromic region may cover the entire surface of the lens, affecting not only the corneal region of the eye but also the sclera. When the lens is on the eye and the photochromic dye is activated, the outer region of the lens darkens. If the peripheral thickness of the lens and the amount of photochromic dye are not selected correctly, the transition from the lens edge to the sclera may appear cosmetically unappealing to the wearer due to the abrupt change in darkness in that region. Furthermore, the vision correction provided by contact lenses is typically achieved by adjusting the refractive power within the optical region.

[0006] The present disclosure can address visual effects where, upon activation of the photochromic dye, the lens thickness profile is designed to optimize color change and on-eye lens behavior. The present disclosure relates to soft contact lenses with either edge-to-edge or center-only photochromic material, where the optic and peripheral regions of the lens are designed to provide a desired cosmetic effect to the eye. As used herein, determining the desired cosmetic effect may be based on a clinical assessment based on a questionnaire regarding the subjective appearance of the lens.

[0007] For the benefit of soft contact lens wearers, the photochromic effect in the pupil region ideally remains constant across the aperture. However, this cannot be achieved because power is a function of thickness variations in the optical region. The so-called photochromic effect is the amount of light transmitted to the eye, described as %T, which represents the percentage of light that passes when the dye is activated. One solution may be achieved by offsetting the anterior curvature by a certain amount from the posterior surface so that the radial thickness along the region remains constant. The radial thickness is the lens thickness calculated in a direction perpendicular to the posterior surface of the lens. This setting provides the same amount of %T regardless of the region of the lens used. However, vision correction obtained by optical power cannot be achieved by this approach because, based on the rules of refraction (Snell's law of refraction), the anterior and posterior surfaces of the lens must have different curvatures to provide a specific optical power.

[0008] Alternatively, or in addition, the photochromic effect in the peripheral region may be substantially similar to that in the inner region. A substantially similar photochromic effect may be defined, for example, as a difference in darkness or %T between the two regions within a threshold. The threshold may be determined by a clinical evaluation in which the subject is asked about multiple cosmetic aspects of the lens within or outside the optical zone. Lenses may vary in the geometry and / or percentage of photochromic dye. Thresholds may be determined using optical modeling of light transmitted through different regions of the lens (central region vs. inner / outer periphery) to establish thresholds / tolerances around the cosmetic aspects of the lens. These thresholds may also vary depending on the target population, determined, for example, by the type of daily activity.

[0009] If the peripheral region is much thicker than the optical region, the periphery will appear much darker and will be less aesthetically appealing to the wearer. This condition will occur with lenses with high minus power, as shown in Figure 1, where the central thickness is smallest and the peripheral thickness is largest, resulting in the largest thickness difference. Similarly, for lenses with high plus power, a large thickness difference will occur between the edge of the optical zone and the peripheral region, as shown in Figure 2.

[0010] A photochromic ophthalmic lens may comprise a body having an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone contain a photochromic dye, the ophthalmic lens having a thickness profile configured based on a cosmetic appearance associated with a target transmittance level (%T), at least a portion of the thickness profile being the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target prescription.

[0011] A photochromic ophthalmic lens may comprise a body having an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone contain a photochromic dye, and the ophthalmic lens has a thickness profile configured with a target transmittance level (%T), at least a portion of the thickness profile being the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target prescription.

[0012] A photochromic ophthalmic lens may comprise a body having an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone contain a photochromic dye, and the ophthalmic lens has a thickness profile configured based on a target transmittance level (%T). [Brief explanation of the drawings]

[0013] The following drawings illustrate generally, by way of example, but not by way of limitation, various embodiments contemplated in the present disclosure. [Figure 1] FIG. 1 is a cross-sectional view of a high minus lens (eg, optical power less than −6.00D). [Figure 2] FIG. 1 is a cross-sectional view of a high plus power lens (eg, refractive power greater than +6.00D). [Figure 3A] Examples of radial peripheral thicknesses of monofocal contact lenses for several SKUs ranging from -12.0D to +8.00D are shown. [Figure 3B] Examples of radial peripheral thicknesses of monofocal contact lenses for several SKUs ranging from -12.0D to +8.00D are shown. [Figure 4A] Examples are shown for soft contact lenses containing 1% activated photochromic dye and soft contact lenses containing 4% activated photochromic dye. [Figure 4B] Examples are shown for soft contact lenses containing 1% activated photochromic dye and soft contact lenses containing 4% activated photochromic dye. [Figure 5] This is an example of a soft contact lens containing 4% activated photochromic dye. [Figure 6] Three different levels of optical zone bond thickness are shown with center thicknesses of 0.240 mm, 0.210 mm, and 0.180 mm. [Figure 7] The volume within the central region of the lens calculated over any 5.00 mm diameter is shown. [Figure 8] Three different levels of optical zone bond thickness are shown: 0.240 mm, 0.210 mm, and 0.180 mm center thickness. [Figure 9] Three different levels of harmonic thickness are shown: 0.240 mm, 0.210 mm, and 0.180 mm center thickness. The harmonic thickness is calculated over a 5.00 mm diameter. [Figure 10]This is an example of a soft contact lens containing 1% activated photochromic dye. [Figure 11] This is an example of a soft contact lens containing 1% activated photochromic dye. DETAILED DESCRIPTION OF THE INVENTION

[0014] In the present disclosure, a contact lens may have a front or surface power, a back or base curve, and an edge. The front and back surfaces of the lens may be defined by at least three regions: an inner region where vision correction is obtained, an outer periphery of the lens that provides mechanical stability of the lens on the eye, and an intermediate region between the inner and outer regions that is used to smoothly blend the two aforementioned regions without creating discontinuities.

[0015] The "optical zone" may be defined as the substantially central portion of the lens and includes vision correction for the wearer's refractive error and / or presbyopia. "Refractive error" may be defined as the refractive power required to provide good vision, generally at distance. This is understood to include myopia or hyperopia. Presbyopia is corrected by algebraically adding a positive optical power to a portion of the optical zone to correct the wearer's near vision requirements. It is recognized that these refractive powers may be produced by refractive means or diffractive means, or both.

[0016] The peripheral zone can provide stabilization of the lens on the eye, including centration and orientation. This region of the lens also provides mechanical properties such as ease of donning and doffing, comfort, and handling related to fit. The tightness of the lens on the eye determines whether it is a loose fit, which can result in excessive movement, or a tight fit, which may not result in sufficient movement. Orientational stability is essential when the optical zone includes non-rotationally symmetric features, such as astigmatism correction and / or high-order aberration correction. The intermediate zone ensures that the optical and peripheral zones meet in a tangent curve. While both the optical and peripheral zones may be designed independently, it is important to note that their designs are strongly related when specific requirements dictate them. For example, a toric lens design with an optical zone for astigmatism may require a specific peripheral zone to maintain the lens in a predetermined orientation on the eye.

[0017] The photochromic effect may be cosmetically achieved with a constant thickness (e.g., within + / - 0.020 mm) across the inner and outer regions of the lens, which cannot be achieved in the inner region of the lens because vision correction is typically achieved by optical power, which requires thickness changes either at the center of the lens or at the edge of the optic zone to accommodate changes in the curvature of the anterior surface of the lens.

[0018] Figure 3 shows typical examples of lens radial thickness for SKUs ranging from -12.0D to 8.00D for monofocal soft contact lenses. The central thickness (CT) can vary from 0.70mm to 0.270mm across the entire SKU range, with minimum and maximum thickness values ​​determined by the refractive index of the lens material, the optical zone diameter selection, and the mechanical properties of the lens material. The maximum peripheral thickness (PT) may also vary based on the same lens material and lens design choices as for the CT.

[0019] In one aspect of the present disclosure, the photochromic effect in the central region of a soft contact lens is achieved by providing a consistent center thickness (e.g., within + / - 0.020 mm) across two or more prescription ranges (e.g., SKUs). The center thickness can be selected depending on the amount of photochromic dye mixed with the monomer and / or the desired level of darkness the lens exhibits when the photochromic dye is activated. If differences in photochromic effect are due to changes in curvature within the optical zone to accommodate the desired power correction, the proposed solution provides similar photochromic effects within the inner region of the optical zone across SKUs. This approach has been shown to be desirable when photochromic contact lenses are specifically designed for subjects with small pupil diameters under low brightness conditions. Low brightness can be described as lighting conditions in which the illuminance does not exceed 400 lux. Light conditions such as cloudy days, sunny sunrise or sunset, office lighting, and moderate levels of indoor lighting are representative of low brightness conditions. Other applications may also be used.

[0020] In one aspect of the present disclosure, the photochromic effect in the central region of a soft contact lens is achieved by providing a consistent radial thickness (e.g., within + / - 0.020 mm) within a given diameter within the optical zone. By way of example, the central thickness is adjusted according to the radial thickness, the index of the lens material, the posterior optical zone radius, and the power correction selected. The radial thickness can be selected depending on the amount of photochromic dye mixed with the monomer and / or the desired level of darkness the lens exhibits when the photochromic dye is activated. If differences in photochromic effect are due to changes in curvature within the optical zone to accommodate the desired power correction, the proposed solution provides similar photochromic effects across SKUs toward the outer regions of the optical zone. This approach is preferred when photochromic contact lenses are specifically designed for subjects with large pupil diameters under low light conditions.

[0021] In one aspect of the present disclosure, the photochromic effect in the central region of a soft contact lens is achieved by providing a consistent, harmonic radial thickness (e.g., within + / - 0.020 mm) within a given diameter within the optical zone. The central thickness is adjusted according to the selection of the harmonic radial thickness, the index of the lens material, the posterior optical zone radius, and the power correction. The harmonic radial thickness can be selected depending on the amount of photochromic dye mixed with the monomer and / or the desired level of darkness the lens will exhibit when the photochromic dye is activated. If the difference in photochromic effect is due to changes in curvature within the optical zone to accommodate the desired power correction, the proposed solution provides similar photochromic effects across SKUs. Such a solution also minimizes the lens volume within the selected diameter, which aids in the manufacturing process, particularly for central-only photochromic lenses, since the amount of photochromic material dispensed is the same.

[0022] In one aspect of the present disclosure, the optical zone of the lens is designed to provide a photochromic effect. The photochromic effect can be achieved based on one or more of the solutions proposed by the present disclosure. The thickness within the optical zone can be adjusted based on the desired darkness, which is determined by the amount of photochromic dye present in the monomer mixture. A lower concentration of photochromic dye may require a greater thickness to achieve the same amount of darkness that can be achieved with a higher concentration of photochromic dye. The thickness can also be adjusted based on the desired amount of %T, which can lead to different levels of darkness.

[0023] Those skilled in the art of soft contact lens design know that a thicker peripheral region provides better handling performance. The thickness of the peripheral region is determined by the stiffness of the material. A harder lens material requires less peripheral thickness than a softer material to achieve the same handling performance. The thickness difference between the edge of the optical zone and the inner peripheral region is managed through an intermediate region, the purpose of which is to smoothly blend both regions. In photochromic lenses, the peripheral region of the lens may be thicker than the inner region of the lens, and a compromise in peripheral thickness may be required to maintain handling and still provide better cosmetic results than conventional lenses.

[0024] Other criteria, such as lens inversion, lens folding, and lens wrapping, typically evaluated by FEA modeling, may also be considered during the lens design process. These criteria, related to the mechanical performance of the lens, may also be included in the cosmetic optimization process and adjusted according to the desired lens performance.

[0025] In power-based soft contact lenses, the optic zone diameter varies across the SKU range due to thickness constraints. High minus lenses, which require a flat front surface curvature, have smaller optic zone diameters than low-power lenses due to greater thickness at the edge of the optic zone. To control thickness at that location, the optic zone diameter is reduced so that its thickness is approximately the same magnitude as the maximum peripheral thickness (Figure 3). High plus lenses, which require a graduated front surface curvature, also have smaller optic zone diameters than low-power lenses due to greater thickness at the center of the optic zone. To control thickness at that location, the optic zone diameter is reduced so that its central thickness is approximately the same magnitude as the maximum peripheral thickness. Therefore, it may be necessary to apply more than one of the proposed solutions to achieve the desired photochromic effect and cosmetic performance based on the intended SKU range. [Example]

[0026] In Figures 4A and 4B, photochromic lenses were obtained using standard soft contact lens geometries, such as Acuvue2 ​​lenses. The lens prescription is -1.00D spherical. The amount of dye varies from 1.0% to 4.0% between the first example (A) and the second example (B). Both images depict the lens when the photochromic dye is activated. In each case, the difference in darkness makes it possible to distinguish between the optical zone and the lens periphery. In this example, the lens center thickness is approximately 0.124 mm, and the maximum peripheral thickness is approximately 0.240 mm.

[0027] In a second example (Figure 5), a -1.00D spherical photochromic lens was obtained using 1% photochromic dye added to the monomer mixture. The center thickness of the lens is approximately 0.080 mm, and the maximum peripheral thickness is approximately 0.203 mm. As with the previous example, the optical zone is lighter in darkness than the peripheral region of the lens. Both regions are very different from each other once the photochromic dye is activated.

[0028] Table 1 below describes OZ geometries for soft contact lenses in which the photochromic effect in the central region of the soft contact lens is achieved by providing a consistent center thickness (e.g., within + / - 0.020 mm) across two or more prescriptions (e.g., SKUs). The lens diameter-base curve combination was selected to be 14.20 mm / 8.40 mm with a material refractive index value of 1.42. In the example provided, the center thickness was set at 0.240 mm.

[0029] [Table 1]

[0030] Figure 6 shows the optical zone junction thickness for three different levels of central thickness: 0.240 mm, 0.210 mm, and 0.180 mm. The optical zone junction thickness is the radial thickness at the edge of the optical zone. Figure 6 also provides the arbitrary optical zone diameter used to obtain the optical zone junction thickness data. Figure 7 shows the volume within the central region of the lens calculated across an arbitrary 5.00 mm diameter. The volume decreases with decreasing central thickness. The rate of volume change remains independent of central thickness within the offered SKU range (-6.00D to +0.00D). Preferably, the variation in lens volume should remain small to minimize the variation in %T across the selected diameter. The diameter selected to set the optical zone junction thickness can also be selected according to a specific population. For example, if the lens is specifically designed for subjects with a small pupil diameter, a diameter within 3.00 mm to 4.50 mm can be selected. If the lens is specifically designed for subjects with large pupil diameters, a diameter between 6.50 mm and 8.00 mm can be selected, or if the lens is specifically designed for subjects with medium pupil diameters, a diameter between 4.50 mm and 6.50 mm can be selected. The proposed approach is applicable to either edge-to-edge or center-only photochromic lenses.

[0031] The optic zone bond thickness can be the result of selecting a combination of base curve, lens material refractive index, center thickness, and optic zone diameter. Equivalent results can be achieved with different combinations of the mentioned parameters. These parameters should be adjusted based on the choice of lens material (modulus), which determines the lens stiffness and therefore handling performance, the percentage of photochromic dye, and / or darkness, which determines the cosmetic appearance.

[0032] Table 2 below describes soft contact lens geometries in which the photochromic effect in the central region of the soft contact lens is achieved by providing a constant radial thickness (e.g., within + / - 0.020 mm) within a given diameter within the optic zone. The lens diameter-base curve combination was selected to be 14.20 mm / 8.40 mm at a material refractive index value of 1.42. In the example provided, the radial thickness was set to 0.210 mm at a diameter of 8.00 mm.

[0033] [Table 2]

[0034] Figure 8 shows three different levels of optical zone bond thickness: 0.240 mm, 0.210 mm, and 0.180 mm center thickness. The same arbitrary optical zone diameter was used to obtain the center thickness. Also, a larger variation in calculated volume across the 5.00 mm diameter is obtained when the optical zone bond thickness is kept constant (e.g., within + / - 0.020 mm) across the SKU range. Adjusting the optical zone diameter can reduce the volume variation. The proposed approach is applicable to either edge-to-edge or center-only photochromic lenses.

[0035] The center thickness can be the result of selecting a combination of base curve, lens material refractive index, optic zone junction thickness, and optic zone diameter. Equivalent results can be achieved with different combinations of the mentioned parameters. These parameters should be adjusted based on the choice of lens material (modulus of elasticity), which determines the lens stiffness and therefore handling performance, the percentage of photochromic dye, and / or darkness, which determines the cosmetic appearance.

[0036] Table 3 below describes soft contact lens geometries in which the photochromic effect in the central region of the soft contact lens is achieved by providing a constant harmonic radial thickness within a given diameter (e.g., within + / - 0.020 mm) within the optic zone. The lens diameter-base curve combination was selected to be 14.20 mm / 8.40 mm at a material refractive index value of 1.42. In the example provided, the harmonic radial thickness was set to 0.240 mm at a diameter of 5.00 mm.

[0037] [Table 3]

[0038] The harmonic thickness of a rotationally symmetric contact lens calculated from a series of (h+1) radial thickness measurements at intervals of equal annular area from the center (point 0) to the edge (point h) of the circular zone exposed to the oxygen flow. The spacing between thickness measurements should allow each successive annulus to be the same area.

[0039]

number

[0040] For rotationally symmetric circular lenses, such as single vision lenses, the harmonic thickness can be calculated along any meridian since the radial thickness profile does not vary with angle. The outer edges of the lens should be omitted during the calculation since there is no thickness at that location.

[0041] For rotationally asymmetric circular lenses, such as toric lenses, the harmonic thickness is then determined from the average of the harmonic thicknesses calculated along multiple meridians around the lens, since the radial thickness profile varies with angle. The outer edges of the lens should be omitted during the calculation, since there is no thickness at that location.

[0042] Figure 9 shows three different levels of harmonic thickness: 0.240 mm, 0.210 mm, and 0.180 mm center thickness. Harmonic thickness is calculated across any 5.00 mm diameter. Maintaining a constant harmonic thickness results in a consistent volume within the same diameter over which harmonic thickness is calculated (e.g., within + / - 0.020 mm). Similar results are obtained when using average thickness instead of harmonic thickness. The use of harmonic thickness allows the calculation method to provide the same contribution to thickness on each ring, thus harmonizing the amount of light transmitted within a selected diameter. The proposed approach is applicable to either edge-to-edge or center-only photochromic lenses.

[0043] The center thickness can be the result of selecting a combination of base curve, lens material refractive index, harmonic thickness, and optic zone diameter. Equivalent results can be achieved with different combinations of the mentioned parameters. These parameters should be adjusted based on the selection of lens material (modulus of elasticity), which determines the lens stiffness and therefore handling performance, the percentage of photochromic dye, and / or darkness, which determines the cosmetic appearance.

[0044] In Figure 10, an edge-to-edge photochromic lens with a spherical power of -1.00D was obtained using 1% photochromic dye added to the monomer mix. The harmonic thickness was set to 0.160 mm at a diameter of 7.00 mm, with a central thickness of 0.158 mm and a maximum peripheral thickness of 0.190 mm. In another example, Figure 11, an edge-to-edge photochromic lens with a spherical power of -1.00D was also obtained using 1% photochromic dye added to the monomer mix. The harmonic thickness was set to 0.120 mm at a diameter of 8.00 mm. The lens central thickness is approximately 0.117 mm, with a maximum peripheral thickness of approximately 0.182 mm. By thickening the optical zone while thinning the peripheral region, a balance of darkness can be achieved throughout the lens while reducing the amount of transmitted light.

[0045] In one aspect of the present disclosure, soft contact lenses may be customized based on the wearer's prescription, the wearer's pupil diameter in low light, and the amount of transmitted light required.

[0046] In one aspect of the present disclosure, the amount of photochromic dye may be gradually adjusted from the center of the lens to the edge of the lens so that either the darkness level or the optical density remains constant across the surface of the lens. The photochromic dye can also be adjusted to balance both the darkness level and the optical density.

[0047] While what has been shown and described is considered to be the most practical and preferred embodiment, it will be apparent that variations from the specific designs and methods described and illustrated will themselves be obvious to those skilled in the art and may be used without departing from the spirit and scope of the invention. The present invention is not limited to the particular constructions described and exemplified, but should be constructed to be consistent with all modifications that may fall within the scope of the appended claims.

[0048] [Embodiment] (1) A photochromic ophthalmic lens, a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone includes a photochromic dye; the ophthalmic lens has a thickness profile configured based on a cosmetic appearance associated with a target transmittance level (%T); A photochromic ophthalmic lens, wherein at least a portion of said thickness profile is the same across two or more stock keeping units (SKUs), each of said two or more SKUs having a different target prescription. (2) The photochromic ophthalmic lens of claim 1, wherein the center thickness is consistent across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both. (3) The photochromic ophthalmic lens of claim 1, wherein the optical zone bond thickness is consistent across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both. (4) The photochromic ophthalmic lens of claim 1, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both. (5) The photochromic ophthalmic lens of claim 1, wherein the volume calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T), or both.

[0049] (6) A photochromic ophthalmic lens as described in embodiment 1, wherein one or more of the cosmetic appearance or the target transmittance level (%T) is achieved based on the configuration of one or more of the central thickness, optical zone junction thickness, harmonic thickness, or volume calculated at a specific diameter. (7) The photochromic ophthalmic lens of embodiment 1, wherein the thickness profile includes one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness. (8) A photochromic ophthalmic lens according to claim 1, wherein the thickness of at least a portion of the peripheral region of the lens is configured based at least on the cosmetic appearance. (9) A photochromic ophthalmic lens as described in embodiment 1, wherein the body is configured based on one or more of the subject's prescription or the subject's pupil diameter under low light conditions. (10) The photochromic ophthalmic lens of claim 1, wherein the amount of photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the desired cosmetic appearance or the target transmittance level (%T), or both.

[0050] (11) A method for producing the photochromic ophthalmic lens according to embodiment 1. (12) A method for customizing the photochromic ophthalmic lens of claim 1 for a wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter. (13) A photochromic ophthalmic lens, a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone includes a photochromic dye; the ophthalmic lens has a thickness profile configured to achieve a target transmittance level (%T); A photochromic ophthalmic lens, wherein at least a portion of said thickness profile is the same across two or more stock keeping units (SKUs), each of said two or more SKUs having a different target prescription. (14) The photochromic ophthalmic lens of embodiment 13, wherein the center thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T). (15) The photochromic ophthalmic lens of embodiment 13, wherein the optical zone bond thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T).

[0051] (16) The photochromic ophthalmic lens of embodiment 13, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T). (17) The photochromic ophthalmic lens of embodiment 13, wherein the volume calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (%T). (18) The photochromic ophthalmic lens of embodiment 13, wherein the target transmittance level (%T) is achieved based on one or more configurations of the central thickness, the optical zone junction thickness, the harmonic thickness, or the volume calculated at a specific diameter. (19) The photochromic ophthalmic lens of embodiment 13, wherein the thickness profile includes one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness. (20) A photochromic ophthalmic lens as described in embodiment 13, wherein the body is configured based on one or more of the subject's prescription or the subject's pupil diameter under low light conditions.

[0052] (21) The photochromic ophthalmic lens of claim 13, wherein the amount of photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmittance level (%T). (22) A method for producing the photochromic ophthalmic lens according to embodiment 13. (23) A method for customizing the photochromic ophthalmic lens of embodiment 13 for a wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter. (24) A photochromic ophthalmic lens, a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone includes a photochromic dye; The photochromic ophthalmic lens has a thickness profile configured based on a target transmittance level (%T). (25) The photochromic ophthalmic lens of embodiment 24, wherein the center thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T).

[0053] (26) The photochromic ophthalmic lens of embodiment 24, wherein the optical zone bond thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T). (27) The photochromic ophthalmic lens of embodiment 24, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T). (28) The photochromic ophthalmic lens of embodiment 24, wherein the volume calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (%T). (29) A photochromic ophthalmic lens according to embodiment 24, wherein the target transmittance level (%T) is achieved based on one or more configurations of the central thickness, the optical zone junction thickness, the harmonic thickness, or the volume calculated at a specific diameter. (30) The photochromic ophthalmic lens of embodiment 24, wherein the thickness profile includes one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness.

[0054] (31) A photochromic ophthalmic lens as described in embodiment 24, wherein the body is configured based on one or more of the subject's prescription or the subject's pupil diameter under low light conditions. (32) The photochromic ophthalmic lens of embodiment 24, wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmittance level (%T). (33) A method for producing the photochromic ophthalmic lens described in embodiment 24. (34) A method for customizing the photochromic ophthalmic lens of embodiment 24 for a wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

Claims

1. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; the Ophthalmic Lens having a thickness profile configured based on a cosmetic appearance associated with a target transmission level (% T); at least a portion of the caliper profile is the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target recipe; A photochromic ophthalmic lens, wherein the optical zone has a volume calculated at a specific diameter that is constant across the two or more SKUs and configured based on the cosmetic appearance or the target transmittance level (%T), or both.

2. 2. The photochromic ophthalmic lens of claim 1, comprising a center thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the cosmetic appearance or the target transmittance level (%T), or both.

3. 2. The photochromic ophthalmic lens of claim 1, comprising an optical zone bond thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the cosmetic appearance or the target transmittance level (%T), or both.

4. 2. The photochromic ophthalmic lens of claim 1, comprising a harmonic thickness calculated at a particular diameter that is constant across the two or more stock keeping units (SKUs) and configured based on the cosmetic appearance or the target transmittance level (%T), or both.

5. The photochromic ophthalmic lens of claim 1 , wherein one or more of the cosmetic appearance or the target transmittance level (%T) are achieved based on configuration of one or more of a center thickness, an optical zone junction thickness, a harmonic thickness, or a volume calculated at a particular diameter.

6. The photochromic ophthalmic lens of claim 1 , wherein the thickness profile comprises one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness.

7. The photochromic ophthalmic lens of claim 1 , wherein the thickness of at least a portion of the peripheral region of the lens is configured based at least on the cosmetic appearance.

8. The photochromic ophthalmic lens of claim 1 , wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

9. The photochromic ophthalmic lens of claim 1 , wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the desired cosmetic appearance or the target transmittance level (% T), or both.

10. A method for producing the photochromic ophthalmic lens according to claim 1 .

11. 13. A method for customizing the photochromic ophthalmic lens of claim 1 for a wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

12. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; the Ophthalmic Lens having a thickness profile configured with a target transmission level (% T); At least a portion of the caliper profile is the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target recipe. the caliper profile is consistent across the two or more stock keeping units (SKUs) and comprises a calculated volume at a particular diameter configured based on the target permeability level (%T); Photochromic eye lenses.

13. 13. The photochromic ophthalmic lens of claim 12, comprising a center thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

14. 13. The photochromic ophthalmic lens of claim 12, comprising an optical zone bond thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

15. 13. The photochromic ophthalmic lens of claim 12, comprising a harmonic thickness calculated at a particular diameter that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T).

16. The photochromic ophthalmic lens of claim 12, wherein the target transmittance level (%T) is achieved based on one or more configurations of center thickness, optical zone junction thickness, harmonic thickness, or volume calculated at a particular diameter.

17. The photochromic ophthalmic lens of claim 12 , wherein the thickness profile comprises one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness.

18. The photochromic ophthalmic lens of claim 12, wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

19. The photochromic ophthalmic lens of claim 12 , wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmission level (% T).

20. A method for producing the photochromic ophthalmic lens according to claim 12.

21. 13. A method for customizing the photochromic ophthalmic lens of claim 12 for a wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

22. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; The ophthalmic lens has a thickness profile configured based on a target transmittance level (% T). the caliper profile is consistent across the two or more stock keeping units (SKUs) and comprises a calculated volume at a specific diameter configured based on the target permeability level (%T); Photochromic eye lenses.

23. 23. The photochromic ophthalmic lens of claim 22, comprising a center thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

24. 23. The photochromic ophthalmic lens of claim 22, comprising an optical zone bond thickness that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

25. 23. The photochromic ophthalmic lens of claim 22, comprising a harmonic thickness calculated at a particular diameter that is constant across the two or more stock keeping units (SKUs) and configured based on the target transmittance level (%T).

26. 23. The photochromic ophthalmic lens of claim 22, wherein the target transmittance level (%T) is achieved based on one or more configurations of center thickness, optical zone junction thickness, harmonic thickness, or volume calculated at a particular diameter.

27. 23. The photochromic ophthalmic lens of claim 22, wherein the thickness profile comprises one or more of a central thickness, an optical zone junction thickness, or a harmonic thickness.

28. 23. The photochromic ophthalmic lens of claim 22, wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

29. 23. The photochromic ophthalmic lens of claim 22, wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmission level (% T).

30. A method for producing the photochromic ophthalmic lens of claim 22.

31. 23. A method for customizing the photochromic ophthalmic lens of claim 22 for a subject wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

32. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; the Ophthalmic Lens having a thickness profile configured based on a cosmetic appearance associated with a target transmission level (% T); at least a portion of the caliper profile is the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target recipe; A photochromic ophthalmic lens, wherein one or more of said cosmetic appearance or said target transmittance level (%T) is achieved based on configuration of one or more of a center thickness, an optical zone junction thickness, a harmonic thickness, or a volume calculated at a particular diameter.

33. 33. The photochromic ophthalmic lens of claim 32, wherein the center thickness is consistent across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both.

34. 33. The photochromic ophthalmic lens of claim 32, wherein the optical zone bond thickness is consistent across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both.

35. 33. The photochromic ophthalmic lens of claim 32, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both.

36. 33. The photochromic ophthalmic lens of claim 32, wherein the calculated volume at the particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the cosmetic appearance or the target transmittance level (%T) or both.

37. 33. The photochromic ophthalmic lens of claim 32, wherein the thickness profile comprises one or more of the central thickness, the optical zone junction thickness, or the harmonic thickness.

38. 33. The photochromic ophthalmic lens of claim 32, wherein a thickness in at least a portion of said peripheral region of said lens is configured based at least on said cosmetic appearance.

39. 33. The photochromic ophthalmic lens of claim 32, wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

40. 33. The photochromic ophthalmic lens of claim 32, wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the desired cosmetic appearance or the target transmittance level (%T), or both.

41. A method for producing the photochromic ophthalmic lens of claim 32.

42. 33. A method for customizing the photochromic ophthalmic lens of claim 32 for a subject wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

43. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; the Ophthalmic Lens having a thickness profile configured with a target transmission level (% T); at least a portion of the caliper profile is the same across two or more stock keeping units (SKUs), each of the two or more SKUs having a different target recipe; A photochromic ophthalmic lens, wherein the target transmission level (%T) is achieved based on one or more configurations of center thickness, optical zone junction thickness, harmonic thickness, or volume calculated at a particular diameter.

44. 44. The photochromic ophthalmic lens of claim 43, wherein the center thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

45. 44. The photochromic ophthalmic lens of claim 43, wherein the optical zone bond thickness is consistent across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

46. 44. The photochromic ophthalmic lens of claim 43, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (%T).

47. 44. The photochromic ophthalmic lens of claim 43, wherein the calculated volume at the particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (% T).

48. 44. The photochromic ophthalmic lens of claim 43, wherein the thickness profile comprises one or more of the central thickness, the optical zone junction thickness, the or harmonic thickness.

49. 44. The photochromic ophthalmic lens of claim 43, wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

50. 44. The photochromic ophthalmic lens of claim 43, wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmission level (% T).

51. A method for producing the photochromic ophthalmic lens of claim 43.

52. 44. A method for customizing the photochromic ophthalmic lens of claim 43 for a subject wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

53. 1. A photochromic ophthalmic lens, comprising: a body including an optical zone and a peripheral zone disposed adjacent to the optical zone, wherein one or more of the optical zone and the peripheral zone include a photochromic dye; the ophthalmic lens has a thickness profile configured based on a target transmittance level (% T); the target transmission level (%T) is achieved based on one or more configurations of a center thickness, an optical zone junction thickness, a harmonic thickness, or a volume calculated at a particular diameter; Photochromic eye lenses.

54. 54. The photochromic ophthalmic lens of claim 53, wherein the center thickness is constant across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

55. 54. The photochromic ophthalmic lens of claim 53, wherein the optical zone bond thickness is consistent across the two or more stock keeping units (SKUs) and configured based on the target transmission level (% T).

56. 54. The photochromic ophthalmic lens of claim 53, wherein the harmonic thickness calculated at a particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (%T).

57. 54. The photochromic ophthalmic lens of claim 53, wherein the calculated volume at the particular diameter is constant across the two or more stock keeping units (SKUs) and is configured based on the target transmittance level (%T).

58. 54. The photochromic ophthalmic lens of claim 53, wherein the thickness profile comprises one or more of the central thickness, the optical zone junction thickness, or the harmonic thickness.

59. 54. The photochromic ophthalmic lens of claim 53, wherein the body is configured based on one or more of a subject's prescription or a subject's pupil diameter in low light conditions.

60. 54. The photochromic ophthalmic lens of claim 53, wherein the amount of the photochromic dye is gradually adjusted across the body based on the lens thickness profile to achieve the target transmission level (% T).

61. A method for producing the photochromic ophthalmic lens of claim 53.

62. 54. A method for customizing the photochromic ophthalmic lens of claim 53 for a subject wearer, the method comprising: determining one or more of the subject's prescription or the subject's pupil diameter; and configuring the thickness profile of the ophthalmic lens based on the determined one or more of the subject's prescription or the subject's pupil diameter.

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