COMPOSITIONS THAT MODULATE COMPLEMENT FACTOR B AND METHODS OF USE THEREOF - Patent application

Abstract

Aspects of the present disclosure provide compounds, compositions and methods for modulating the expression or activity of complement factor B (CFB). In certain aspects, the compounds, compositions and methods of the present disclosure can be used to reduce the expression of CFB mRNA in a cell or animal. In certain aspects, the compounds, compositions and methods of the present disclosure can be used to reduce the expression of CFB protein in a cell or animal. In certain embodiments, the animal has or is at risk for a complement pathway-related disease, disorder or condition, or a symptom thereof.