Artificial respiration system

Abstract

To provide an artificial respiration system capable of improving a ventilation effect in high-frequency oscillation ventilation.SOLUTION: An artificial respiration system 100 for supplying intake gas Gi containing helium and oxygen to a patient X includes: a connection tube 1, one end 1a of which is connected to the patient X; and an intake gas supply device 2 connected to the other end 1b of the connection tube 1 for sending the intake gas Gi to which oscillation is given at a predetermined ventilation frequency to the connection tube 1. The ventilation frequency is 15 Hz or higher, preferably 45 Hz or lower, more preferably 25-45 Hz, and further preferably 25-35 Hz.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to an artificial ventilation system using a high frequency oscillatory ventilation method. [Background technology]

[0002] Conventionally, one method of artificial respiration is the High Frequency Oscillation (HFO). This method ventilates by oscillating the inhaled gas at a high frequency, with a tidal volume less than the anatomical dead space. This method can keep the airway pressure lower than in general artificial respiration, which applies pressure to the inhaled gas and sends it to the lungs. It is widely known as an artificial respiration method that is particularly effective for newborns whose respiratory organs are underdeveloped.

[0003] In such high-frequency oscillatory ventilation methods, a gas containing oxygen (e.g., a mixture of air and oxygen) is generally used as the inhaled gas. However, as described in Patent Document 1, for example, it is also possible to use a mixture of helium and oxygen as the inhaled gas. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent No. 6104513 Summary of the Invention [Problem to be solved by the invention]

[0005] As described in Patent Document 1, when a mixture of helium and oxygen is used as inhalation gas in high-frequency oscillatory ventilation, helium has a low density and allows the inhalation gas to flow easily even through narrow airways, which is expected to improve the ventilation effect. However, there is still a demand for further improvements in the ventilation effect. [Means for solving the problem]

[0006] Therefore, the present invention provides an artificial respiration system that can further improve the ventilation effect in high-frequency oscillatory ventilation.

[0007] An artificial ventilation system according to one embodiment of the present invention is an artificial ventilation system that supplies an inhalation gas containing helium and oxygen to a patient, and comprises a connection tube having one end connected to the patient, and an inhalation gas supply device connected to the other end of the connection tube and supplying the inhalation gas, which has been vibrated at a predetermined ventilation frequency, to the connection tube, the ventilation frequency being 15 Hz or higher.

[0008] In the artificial respiration system, the ventilation frequency may be 45 Hz or less.

[0009] In the artificial respiration system, the ventilation frequency may be 25 Hz or more and 45 Hz or less.

[0010] In the artificial respiration system, the ventilation frequency may be equal to or greater than 25 Hz and equal to or less than 35 Hz.

[0011] In the above artificial respiration system, the intake gas supply device may include a reservoir connected to the other end of the connecting tube, a main gas supplier which supplies main gas containing oxygen while vibrating the main gas at the ventilation frequency, a main gas flow passage which connects the main gas supplier to the reservoir and through which the main gas flows and which transmits the vibration at the ventilation frequency to the reservoir, and a helium / oxygen supply device which introduces a helium / oxygen mixed gas, which is a gas containing helium and oxygen, into the reservoir or the connecting tube, and the reservoir may define a space for mixing the main gas and the helium / oxygen mixed gas.

[0012] In the above artificial respiration system, the helium / oxygen supply device may include a helium supply source that stores helium, an oxygen supply source that stores oxygen, a helium supply path that connects between the helium supply source and the oxygen supply source and the reservoir, or between the helium supply source and the oxygen supply source and the connecting tube, and a gas mixer that is provided midway along the helium supply path and mixes helium from the helium supply source and oxygen from the oxygen supply source to generate the helium / oxygen mixed gas.

[0013] In the above artificial respiration system, the helium / oxygen supply device may have a mixed gas supply source that stores helium / oxygen mixed gas, and a helium supply path that connects between the mixed gas supply source and the reservoir or between the mixed gas supply source and the connecting tube.

[0014] In the above artificial ventilation system, the main gas flow passage may include a supply passage that supplies the main gas to the reservoir, and a recovery passage that recovers the main gas from the reservoir.

[0015] In the above artificial respiration system, the intake gas supply device includes a main gas supplier which supplies a main gas containing oxygen while vibrating the main gas at the ventilation frequency, a main gas flow passage which connects the main gas supplier to the connecting tube and through which the main gas flows, and a helium / oxygen supply device which introduces a helium / oxygen mixed gas which is a gas containing helium and oxygen, into the main gas supplier, and the main gas supplier may supply the helium / oxygen mixed gas together with the main gas while vibrating the helium / oxygen mixed gas at the ventilation frequency.

[0016] In the above artificial ventilation system, the main gas flow passage may have a supply path for supplying the main gas and the helium / oxygen mixed gas to the connecting tube, and a recovery path for recovering the main gas and the helium / oxygen mixed gas from the connecting tube.

[0017] In the above artificial respiration system, the inhalation gas supply device may further include a helium recovery device that recovers helium in the helium / oxygen mixed gas flowing through the recovery path.

[0018] An artificial ventilation system according to another aspect of the present invention is an artificial ventilation system for supplying an intake gas containing helium and oxygen to a patient, comprising a connecting tube having one end connected to the patient, and an intake gas supplying device connected to the other end of the connecting tube and supplying the intake gas vibrated at a predetermined ventilation frequency to the connecting tube, wherein the intake gas supplying device has a reservoir connected to the other end of the connecting tube, a main gas supplying device for supplying a main gas containing oxygen, a main gas flow passage connecting the main gas supplying device and the reservoir and through which the main gas flows, and a helium / oxygen supplying device for introducing a helium / oxygen mixed gas, which is a gas containing helium and oxygen, into the reservoir or the connecting tube, and wherein the reservoir defines a space for mixing the main gas and the helium / oxygen mixed gas. Effect of the Invention

[0019] According to the above-mentioned artificial respiration system, it is possible to improve the ventilation effect in high-frequency oscillatory ventilation. [Brief description of the drawings]

[0020] [Figure 1] 1 is a schematic diagram of an artificial ventilation system according to a first embodiment of the present invention. FIG. [Diagram 2] FIG. 2 is a schematic diagram of a first modified example of the artificial respiration system. [Diagram 3] FIG. 11 is a schematic diagram of a second modified example of the artificial respiration system. [Figure 4] FIG. 4 is a schematic diagram of an artificial ventilation system according to a second embodiment of the present invention. [Diagram 5] FIG. 1 is a schematic diagram of an artificial ventilation system used in the experiments in the examples. [Figure 6] 1 is a graph showing the results of Experiment 1 of the above embodiment. [Figure 7] 13 is a graph showing the results of Experiment 2 of the above embodiment. [Figure 8] 13 is a graph showing the results of Experiment 3 of the above embodiment. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0021] First Embodiment Hereinafter, a first embodiment of the present invention will be described in detail with reference to the drawings. (Overall composition) 1, the artificial ventilation system 100 is a system that supplies an inhaled gas Gi to a patient X by high frequency oscillation (hereinafter referred to as "HFO"). That is, the artificial ventilation system 100 includes a connection tube 1 connected to the trachea of ​​the patient X, and an inhaled gas supply device 2 that delivers the inhaled gas Gi to the connection tube 1.

[0022] (connecting tube) One end 1a of the connection tube 1 is connected to a patient. In this embodiment, a portion of the one end 1a of the connection tube 1 is inserted into the trachea of ​​the patient X and left therein. That is, the connection tube 1 is an intubation tube, but is not particularly limited as long as it is one generally used in artificial respirators. The connection tube 1 is inserted into the trachea of ​​the patient X by nasal intubation, oral intubation, or tracheotomy. The other end 1b of the connection tube 1 located outside the trachea of ​​the patient X is connected to one end 23a of a reservoir 23 in an intake gas supply device 2, which will be described in detail later. In addition, a helium inlet 1c to which a helium supply path 35 of the intake gas supply device 2, which will be described in detail later, is connected, is formed between the one end 1a and the other end 1b of the connection tube 1.

[0023] (Intake gas supply device) In this embodiment, the intake gas supply device 2 constitutes a so-called Jackson Rees circuit. That is, the intake gas supply device 2 includes a compressor 20 that generates compressed air, a main gas supplier 21 that supplies the compressed air as a main gas (oxygen-containing gas) Gm, a main gas flow passage 22 and a reservoir 23 that connect the main gas supplier 21 and the connection tube 1, and a helium / oxygen supplier 24 that introduces a gas containing helium and oxygen into the reservoir 23.

[0024] (Compressor) The compressor 20 takes in air A from the outside and generates compressed air. The compressor 20 may be any type that is generally used in artificial ventilators, and the structure is not particularly limited.

[0025] (Main gas supply) The main gas supplier 21 is connected to the compressor 20, takes in compressed air from the compressor 20 to produce the main gas Gm, and supplies the main gas Gm while applying vibrations at a predetermined ventilation frequency, and is an HFO ventilator that performs ventilation by HFO. The structure of the main gas supplier 21 is not particularly limited, but a piston-type HFO ventilator is preferable. The compressor 20 is not essential, and compressed air may be taken directly into the main gas supplier 21 from piping in a hospital or the like where the artificial respiration system 100 is installed.

[0026] Furthermore, in this embodiment, the main gas supplier 21 is set to impart vibration to the main gas Gm at a ventilation frequency of 15 Hz or more, preferably 45 Hz or less, more preferably 25 Hz or more and 45 Hz or less, even more preferably 25 Hz or more and 35 Hz, and most preferably 35 Hz.

[0027] (Main gas flow passage) The main gas flow passage 22 connects the main gas supplier 21 to the other end 23b of the reservoir 23, which will be described later in detail, and is a pipe through which the main gas Gm flows. The main gas flow passage 22 has a supply passage 22a that supplies the main gas Gm to the reservoir 23, and a recovery passage 22b that recovers the main gas Gm from the reservoir 23. The supply passage 22a and the recovery passage 22b are provided in parallel. The recovery passage 22b is connected to an exhaust port 21x provided in the main gas supplier 21, so that the main gas Gm that flows into the main gas supplier 21 through the recovery passage 22b is exhausted to the outside of the main gas supplier 21. Hereinafter, the main gas Gm flowing through the supply passage 22a will be referred to as the "supply side main gas Gms", and the main gas Gm flowing through the recovery passage 22b will be referred to as the "recovery side main gas Gme".

[0028] The supply path 22a and the recovery path 22b are connected to each other on the side closer to the main gas supplier 21 than the other end 23b of the reservoir 23 described later, i.e., upstream of this other end 23b in the flow direction of the supply side main gas Gms, so that the main gas Gm is always flowing through the supply path 22a and the recovery path 22b.

[0029] (Reservoir) The reservoir 23 is a conduit that connects the other end 1b of the connection tube 1 and the main gas flow passage 22, and is formed, for example, of a hard material with relatively little vibration damping. In this embodiment, a serpentine tube (flexible tube) is used for the reservoir 23. The reservoir 23 defines a space therein for mixing the supply-side main gas Gms delivered from the main gas supplier 21 via the supply passage 22a of the main gas flow passage 22 with a helium / oxygen mixed gas Gx, which will be described later.

[0030] (Helium / Oxygen Supply) Helium / oxygen supply device 24 has a helium supply source 30 that stores helium, an oxygen supply source 31 that stores oxygen, a helium supply path 35 that connects helium supply source 30 and oxygen supply source 31 to reservoir 23, and a gas mixer 32 provided midway along helium supply path 35.

[0031] The helium source 30 is a helium tank and the oxygen source 31 is an oxygen tank.

[0032] The gas mixer 32 generates a helium / oxygen mixed gas Gx by mixing helium from the helium supply source 30 and oxygen from the oxygen supply source 31. In the gas mixer 32, the mixture ratio of helium and oxygen is appropriately adjusted.

[0033] One end 35a of the helium supply passage 35 is connected to the reservoir 23, for example, at a position close to one end 23a of the reservoir 23 (a position close to the other end 1b of the connection tube 1). Then, the helium / oxygen mixed gas Gx from the gas mixer 32 is introduced into the reservoir 23, and the helium / oxygen mixed gas Gx is mixed with the main gas Gm in the reservoir 23 to become the intake gas Gi. At this time, the vibration of the ventilation frequency given to the main gas Gm (supply side main gas Gms) in the main gas supplier 21 is transmitted to the reservoir 23 and the connection tube 1 by the main gas flow passage 22, and the vibration of the ventilation frequency is also given to the entire intake gas Gi consisting of the main gas Gm and the helium / oxygen mixed gas Gx.

[0034] (Action and effect) According to the artificial respiration system 100 of the present embodiment described above, the inhaled gas Gi can be supplied to the trachea of ​​the patient X by applying vibrations at a ventilation frequency of 15 Hz or more, preferably 45 Hz or less, more preferably 25 Hz or more and 35 Hz or less, even more preferably 25 Hz or more and 35 Hz or less, and most preferably 35 Hz. As a result, by using ultra-high frequency vibration ventilation that applies vibrations at a frequency of 15 Hz or more to the inhaled gas Gi while reducing the flow resistance of the inhaled gas Gi by using the inhaled gas Gi containing helium with a relatively low density, it becomes possible to propagate vibrations up to the alveolar level, and the inhaled gas Gi can be reliably delivered to the respiratory organs of the patient X, thereby improving the ventilation effect compared to high frequency vibration ventilation of less than 15 Hz.

[0035] In addition, since the intake gas supply device 2 constituting the Jackson Rees circuit is used and the helium / oxygen mixed gas Gx is introduced into the reservoir 23 by the helium / oxygen supply device 24, the amount of helium / oxygen mixed gas Gx used can be reduced compared to the case where the helium / oxygen mixed gas Gx is sent from the main gas supply device 21 together with the main gas Gm. That is, when the helium / oxygen mixed gas Gx is sent from the main gas supply device 21 together with the main gas Gm, the helium / oxygen mixed gas Gx is constantly flowing through the main gas flow passage 25 together with the main gas Gm, and the amount of helium / oxygen mixed gas Gx that does not reach the trachea of ​​the patient X and does not contribute to breathing increases, resulting in wasteful consumption of the helium / oxygen mixed gas Gx. In this regard, by using the intake gas supply device 2 of this embodiment, it is only necessary to introduce the helium / oxygen mixed gas Gx into the reservoir 23 and the connection tube 1 in an amount (for example, about 4 to 8 [L / min]) required for breathing, so that the amount of expensive helium used can be reduced, leading to cost reduction.

[0036] In this embodiment, the ventilation frequency is set to 15 Hz or more, preferably 45 Hz or less, more preferably 25 Hz or more and 45 Hz or less, even more preferably 25 Hz or more and 35 Hz or less, and most preferably 35 Hz, but is not necessarily limited to this condition, and the artificial respiration system 100 may be operated at other frequencies. In this case, by adopting at least the intake gas supply device 2 constituting the Jackson-Rees circuit, the amount of expensive helium used can be reduced, so that it is possible to achieve a high ventilation effect by using helium while reducing costs.

[0037] 2, the helium / oxygen supply device 24X may have a mixed gas supply source 30X that stores a helium / oxygen mixed gas (heliox) instead of the above-mentioned helium supply source 30 and oxygen supply source 31. In this case, the above-mentioned gas mixer 32 is also unnecessary, and the device configuration can be simplified.

[0038] 3, a helium supply path 35Y of the helium / oxygen supply device 24Y may connect the helium supply source 30 and the oxygen supply source 31 to the connection tube 1. In this case, one end 35Ya of the helium supply path 35Y is connected to the helium inlet 1c of the connection tube 1, and the helium / oxygen mixed gas Gx from the gas mixer 32 is introduced into the connection tube 1. Note that the mixed gas supply source 30X shown in FIG. 2 may also be used in the helium / oxygen supply device 24Y.

[0039] Second Embodiment Next, a second embodiment of the present invention will be described in detail with reference to the drawings. Note that the same components as those in the first embodiment are designated by the same reference numerals as those in the first embodiment, and the description thereof will be omitted.

[0040] (Overall composition) 4, in the artificial respiration system 100A of this embodiment, the intake gas supply device 2A does not constitute a Jackson-Rees circuit. That is, the intake gas supply device 2A has a main gas supplier 41, a main gas flow passage 22, a helium / oxygen supplier 24, and a helium collector 43 that collects helium from the main gas flow passage 22.

[0041] The main gas supplier 41, like the main gas supplier 21 of the first embodiment, is a device that takes in compressed air from the compressor 20 to produce main gas Gm, and supplies this main gas Gm through the main gas flow passage 22 while applying vibration at a predetermined ventilation frequency to the main gas Gm. The main gas supplier 41 is provided with an exhaust port 41x that communicates with the recovery passage 22b of the main gas flow passage 22.

[0042] Moreover, helium / oxygen mixed gas Gx is introduced into the main gas supplier 41 from the helium / oxygen supplier 24. Then, the main gas supplier 41 supplies the helium / oxygen mixed gas Gx together with the main gas Gm through the main gas flow passage 22 while vibrating the helium / oxygen mixed gas Gx at a ventilation frequency. That is, the main gas supplier 41 mixes the main gas Gm and the helium / oxygen mixed gas Gx and supplies the mixture.

[0043] In this embodiment, the main gas flow passage 22 is directly connected to the other end 1b of the connection tube 1, and no configuration corresponding to the reservoir 23 described in the first embodiment is provided. Therefore, the supply path 22a and the recovery path 22b of the main gas flow passage 22 communicate with each other on the side closer to the main gas supplier 41 than the other end 1b of the connection tube 1, that is, on the upstream side in the flow direction of the supply side main gas Gms than the other end 1b.

[0044] The helium recovery device 43 is connected to the exhaust port 41x of the main gas supply device 41, and communicates with the recovery path 22b via the main gas supply device 41. The helium recovery device 43 has an adsorbent or the like (not shown), and adsorbs and separates helium from the recovery side main gas Gme to recover only helium.

[0045] (Action and effect) In the artificial respiration system 100A, helium is mixed with the main gas Gm beforehand and then supplied to the patient X, so that the inhaled gas Gi is continuously supplied to the patient X, resulting in a large amount of helium usage. However, by providing a helium recovery device 43, the helium can be recovered by the helium recovery device 43, making it possible to reuse expensive helium, leading to cost reduction.

[0046] In this embodiment, like a helium / oxygen supplying device 24X shown in FIG. 2, a mixed gas supplying source 30X that stores helium / oxygen mixed gas (heliox) may be provided instead of the helium supplying source 30 and the oxygen supplying source 31 described above.

[0047] The present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the spirit and scope of the present invention.

[0048] The connection tube 1 does not have to be an intubation tube that is inserted into the trachea of ​​the patient X and left there. For example, one end 1a of the connection tube 1 may be connected to a mask (not shown) worn by the patient X.

[0049] Furthermore, the main gas Gm does not have to be compressed air, and is not particularly limited as long as it is an oxygen-containing gas that contains an appropriate amount of oxygen for breathing. EXAMPLES

[0050] Next, we will explain the results of an experiment conducted to confirm the ventilation effect using the artificial respiration system. Experimental Equipment The artificial respiration system 200 used in the experiment corresponds to the artificial respiration system 100 of the first embodiment. Therefore, as shown in Fig. 5, the intake gas supply device 202 of the artificial respiration system 200 constitutes a so-called Jackson-Rees circuit. In the experiment, a connection tube 201 was orally intubated into the trachea of ​​an animal (rabbit) serving as subject Y instead of patient X (tracheotomy may also be used). Subject Y weighs about 3 kg.

[0051] In the experiments, the following products were used for the artificial respiration system 200. Compressor 220: MACS-50 manufactured by Tokibo Co., Ltd. Main gas supply 221: Humming Vue manufactured by Metran Co., Ltd. Reservoir 223: Corrugated tube (capacity: 100 [ml])

[0052] Experimental conditions Compressed air to be the main gas Gm was vibrated at the following ventilation frequency from the main gas supplier 221 and sent at a flow rate of 10 [L / min]. Also, helium / oxygen mixed gas Gx was sent from the helium / oxygen supplier 224 toward the reservoir 223 at 8 [L / min]. In the experiment, the ventilation frequency was 15 Hz in Example 1, 25 Hz in Example 2, 35 Hz in Example 3, and 45 Hz in Example 4. Also, as a comparative example for comparison with Examples 1 to 4, an experiment was performed in which the ventilation frequency was 5 Hz.

[0053] (Experiment 1) In experiment 1, first, the helium / oxygen mixed gas Gx was supplied with a volume ratio of helium to oxygen (helium:oxygen) of 0%:100% (Pre-He in FIG. 6), then the helium / oxygen mixed gas Gx was supplied to the connecting tube 201 with a volume ratio of helium to oxygen (helium:oxygen) of 79%:21% (He-on in FIG. 6), and finally the helium / oxygen mixed gas Gx was supplied with a volume ratio of helium to oxygen (helium:oxygen) of 0%:100% again (Post-He in FIG. 6).

[0054] Fig. 6 shows the results of measuring the arterial blood carbon dioxide partial pressure (hereinafter, PaCO2 [mmHg]) of subject Y when experiment 1 was performed under the above conditions. The horizontal axis indicates the presence or absence of helium in the inhaled gas Gi, and the vertical axis indicates the PaCO2 value of subject Y. The PaCO2 value of the experimental results is the average value of the results of experiments performed four times for each of Examples 1 to 4 and the Comparative Example.

[0055] 6, regardless of the presence or absence of helium, the PaCO2 values ​​were lower in all of Examples 1 to 4 compared to the Comparative Example, and it was confirmed that the ventilation effect was improved when the ventilation frequency was 15 Hz or more. Furthermore, it was confirmed that the ventilation effect was the highest in Example 3 (ventilation frequency was 35 Hz), and the ventilation effect was second highest in Example 2 (ventilation frequency was 25 Hz) after Example 3.

[0056] Furthermore, in Example 2 (25 Hz), Example 3 (35 Hz), and Example 4 (45 Hz), it was confirmed that when helium was included in the inhalation gas Gi (He-on in FIG. 6), the amount of reduction in PaCO2 from the comparative example (5 Hz) was greater than when helium was not included in the inhalation gas Gi (Pre-He and Post-He in FIG. 6). Therefore, it was confirmed that when helium was used for the inhalation gas Gi, an improvement in the ventilation effect can be expected especially when the ventilation frequency is 25 Hz or more and 45 Hz or less.

[0057] (Experiment 2) Next, experiment 2 was carried out in which the oxygen concentration was constant, unlike experiment 1. In experiment 2, a nitrogen supply source (not shown) was provided in the experimental apparatus, and nitrogen was first substituted for helium and oxygen was supplied at a volume ratio (nitrogen:oxygen) of 70%:30% (Pre-He in FIG. 7), then helium / oxygen mixed gas Gx was supplied to the connection tube 201 at a volume ratio (helium:oxygen) of 70%:30% (He-on in FIG. 7), and finally the nitrogen and oxygen volume ratio (nitrogen:oxygen) was again supplied at 70%:30% (Post-He in FIG. 7).

[0058] The results of measuring the arterial blood carbon dioxide partial pressure (hereinafter, PaCO2 [mmHg]) of subject Y when experiment 2 was performed under the above conditions are shown in Figure 7. The PaCO2 values ​​in the experimental results are the average values ​​of the results of experiments performed three times for each of Examples 1 to 4 and the Comparative Example.

[0059] 7, in the comparative example, the PaCO2 value hardly changed depending on the presence or absence of helium, whereas the PaCO2 value decreased in the presence of helium in all of Examples 1 to 4. Therefore, it was confirmed that a high ventilation effect can be expected by including helium in the inhaled gas Gi in ultra-high frequency vibration ventilation in which vibrations of a frequency of 15 Hz or more (especially 35 Hz) are applied to the inhaled gas Gi.

[0060] (Experiment 3) Next, in Experiment 3, an experiment was conducted to confirm the difference in PaCO2 value and the difference in amplitude (airway pressure amplitude) value in the peripheral airways depending on the presence or absence of helium in each of Examples 1 to 4 (using the same individual). As in Experiment 2, in this experiment, when "with helium", the helium / oxygen mixed gas Gx was supplied with a volume ratio of helium to oxygen (helium:oxygen) of 70%:30%, and when "without helium", gas was supplied with a volume ratio of nitrogen instead of helium to oxygen (nitrogen:oxygen) of 70%:30%.

[0061] Experiment 3 was performed under the above conditions. As a result, although there was no significant difference in the amplitude (airway pressure amplitude) values ​​in the peripheral airways depending on whether or not helium was present in any of Examples 1 to 4, the PaCO2 values ​​were smaller in the presence of helium compared to the absence of helium in any of Examples 1 to 4, confirming that the use of a gas containing helium improves the effectiveness of CO2 excretion. [Industrial Applicability]

[0062] According to the artificial respiration system of the present invention, it is possible to improve the ventilation effect in high-frequency oscillatory ventilation. [Explanation of symbols]

[0063] 1, 201…connecting tube 2, 2A, 202…Intake gas supply device 20, 220...Compressor 21, 41, 221...Main gas supply 22...Main gas passage 22a…Supply route 22b...Recovery route 23, 223…Reservoir 24, 24X, 24Y, 224…Helium / Oxygen Supply Unit 25…Main gas passage 30…Helium supply source 30X…mixed gas supply source 31...Oxygen supply source 32...Gas mixer 35, 35Y…Helium supply line 43…Helium collector 100, 100A, 200… Artificial ventilation system Gi…intake gas Gm…Main gas Gx: Helium / oxygen mixed gas X…Patient

Claims

1. 1. An artificial ventilation system for supplying an inhalation gas containing helium and oxygen to a patient, comprising: a connecting tube, one end of which is connected to the patient; an intake gas supply device connected to the other end of the connecting tube and configured to supply the intake gas to the connecting tube after vibrating the intake gas at a predetermined ventilation frequency; Equipped with An artificial respiration system, wherein the ventilation frequency is 15 Hz or higher.

2. 2. The artificial respiration system according to claim 1, wherein the ventilation frequency is 45 Hz or less.

3. 2. The artificial respiration system according to claim 1, wherein the ventilation frequency is between 25 Hz and 45 Hz.

4. 2. The artificial respiration system according to claim 1, wherein the ventilation frequency is between 25 Hz and 35 Hz.

5. The intake gas supply device includes: a reservoir connected to the other end of the connection tube; a main gas supplier that supplies a main gas containing oxygen while applying vibration at the ventilation frequency to the main gas; a main gas flow passage connecting the main gas supplier and the reservoir, through which the main gas flows and through which the vibration of the ventilation frequency is transmitted to the reservoir; a helium / oxygen supply device that introduces a helium / oxygen mixed gas, which is a gas containing helium and oxygen, into the reservoir or the connecting tube; having 5. The artificial ventilation system according to claim 1, wherein the reservoir defines a space for mixing the main gas and the helium / oxygen mixed gas.

6. The helium / oxygen supply device a helium source for storing helium; An oxygen source that stores oxygen; a helium supply line connecting the helium supply source and the oxygen supply source to the reservoir or connecting the helium supply source and the oxygen supply source to the connecting tube; a gas mixer provided in the helium supply line for mixing the helium from the helium supply source and the oxygen from the oxygen supply source to generate the helium / oxygen mixed gas; 6. The artificial ventilation system of claim 5, further comprising:

7. The helium / oxygen supply device a mixed gas supply source storing a helium / oxygen mixed gas; a helium supply line connecting the mixed gas supply source and the reservoir or connecting the mixed gas supply source and the connecting tube; 6. The artificial ventilation system of claim 5, further comprising:

8. The main gas flow passage is a supply passage for supplying the main gas to the reservoir; a recovery passage for recovering the main gas from the reservoir; 6. The artificial ventilation system of claim 5, further comprising:

9. The intake gas supply device includes: a main gas supplier that supplies a main gas containing oxygen while applying vibration at the ventilation frequency to the main gas; a main gas flow passage that connects the main gas supplier and the connection tube and through which the main gas flows; a helium / oxygen supply device for introducing a helium / oxygen mixed gas, which is a gas containing helium and oxygen, into the main gas supply device; having 5. The artificial respiration system according to claim 1, wherein the main gas supplier supplies the helium / oxygen mixed gas together with the main gas while applying vibration to the helium / oxygen mixed gas at the ventilation frequency.

10. The main gas flow passage is a supply line for supplying the main gas and the helium / oxygen mixed gas to the connecting tube; a recovery passage for recovering the main gas and the helium / oxygen mixed gas from the connection tube; 10. The artificial ventilation system of claim 9, further comprising:

11. 11. The artificial respiration system according to claim 10, wherein the intake gas supply device further comprises a helium recovery device that recovers helium in the helium / oxygen mixed gas flowing through the recovery path.

12. 1. An artificial ventilation system for supplying an inhalation gas containing helium and oxygen to a patient, comprising: a connecting tube, one end of which is connected to the patient; an intake gas supply device connected to the other end of the connecting tube and configured to supply the intake gas to the connecting tube after vibrating the intake gas at a predetermined ventilation frequency; Equipped with The intake gas supply device includes: a reservoir connected to the other end of the connection tube; a main gas supplier that supplies a main gas containing oxygen; a main gas flow passage connecting the main gas supplier and the reservoir and through which the main gas flows; a helium / oxygen supply device that introduces a helium / oxygen mixed gas, which is a gas containing helium and oxygen, into the reservoir or the connecting tube; having The reservoir defines a space in which the main gas and the helium / oxygen mixed gas are mixed.

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