System and method for locking controlled medical treatment device

Abstract

To provide a system and a method for controlling a locking type medicine distribution device.SOLUTION: A distribution device 100 can include a housing part and a nozzle part 108 that can be pushed down inside a housing 102 for administering a medicine. The device can include a vial lock for fixing medicine vials in the device and a nozzle lock for controlling the administration of the medicine. The distribution device can further include a biological sensor and / or a sensor for identifying a user such as a micro gesture sensor. Parameters for locking the nozzle and / or the vials can be configured through a device of a doctor. A reminder, user pairing, and other user communication can be facilitated through a device of a patient.SELECTED DRAWING: Figure 3A

Description

Technical Field

[0001] [Cross - Reference to Related Applications] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 969,421, filed on February 3, 2020, the entire disclosure of which is incorporated herein by reference.

[0002] The present invention relates to systems and methods for controlling the dispensing of medications, and more particularly, to systems and methods for dispensing medications via a time - controlled device coupled to a web platform.

Background Art

[0003] Conventional personal medication dispensing devices, such as nasal spray devices, are often effectively used to deliver atomized medications. Conventional nasal spray devices consist of a pump with an elongated nozzle that atomizes the liquid as it is propelled from a supply orifice through the nozzle. The resulting mist is inhaled and efficiently absorbed by the tissues, thereby providing an effective treatment.

[0004] Nasal spray devices have been used to provide medications for symptoms ranging from allergies, pain relief, and depression. For conditions such as pain relief and depression, due to the addictive nature of the medications used to treat these conditions, there is a high risk of abuse associated with the medications provided in the device. For example, ketamine has shown great effectiveness in the treatment of severe conditions such as bipolar depression. However, considering the addictive nature of medications such as ketamine, healthcare providers either administer them for home use or otherwise prescribe them. ​​​​​​​​​​​hesitate. Healthcare providers are often concerned about patients who misuse or abuse drugs, people other than patients who abuse drugs, and theft and / or sale of drugs. Misuse and abuse are not only due to the addictive nature of the drug, but also due to the efficacy of the drug in delivering relief of the patient's condition. Patients may be driven to use more than the prescribed dosage for the relief provided by the drug. As a result, patients who need such drugs may only receive a small dosage or supply each time they visit a healthcare provider. As a result, some patients may have to visit a healthcare provider frequently, such as multiple times a week. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time.

[0005] Misuse and abuse are due not only to the addictive nature of the drug, but also to the efficacy of the drug in delivering relief of the patient's condition. The patient may be driven to use more than the prescribed dosage for the relief provided by the drug. As a result, patients who need such drugs may only receive a small dosage or supply each time they visit a healthcare provider. As a result, some patients may have to visit a healthcare provider frequently, such as multiple times a week. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time. The need for many visits to a healthcare provider is not only inconvenient, but can also act as a barrier to access to the drug for people who cannot afford the costly transportation or who cannot be away from their place of employment for long periods of time. SUMMARY OF THE INVENTION

[0006] A system and method for dispensing a drug using a locking dispensing device are provided. The dispensing device can be shaped to form an outer skeleton around a pharmaceutical vial. The dispensing device can include one or more locking mechanisms to prevent removal of the vial and / or administration of a dosage. The system can include a computing device linked to the dispensing device to configure parameters (e.g., timeout, unauthorized change detection, inappropriate use, biometric input, user authentication) of the dispensing device to engage and / or disengage the locking mechanism. The dispensing device can be shaped to form an outer skeleton around a pharmaceutical vial. The dispensing device can include one or more locking mechanisms to prevent removal of the vial and / or administration of a dosage. The system can include a computing device linked to the dispensing device to configure parameters (e.g., timeout, unauthorized change detection, inappropriate use, biometric input, user authentication) of the dispensing device to engage and / or disengage the locking mechanism. The system can include a computing device linked to the dispensing device to configure parameters (e.g., timeout, unauthorized change detection, inappropriate use, biometric input, user authentication) of the dispensing device to engage and / or disengage the locking mechanism. The system can include a computing device linked to the dispensing device to configure parameters (e.g., timeout, unauthorized change detection, inappropriate use, biometric input, user authentication) of the dispensing device to engage and / or disengage the locking mechanism. The system can include a computing device linked to the dispensing device to configure parameters (e.g., timeout, unauthorized change detection, inappropriate use, biometric input, user authentication) of the dispensing device to engage and / or disengage the locking mechanism.

[0007] The dispensing device can include integral or separate components that are slidably engaged with each other to form an outer skeleton around the vial. It can include a nozzle and a housing that can be made of components that can be integrally or separately formed and can be slidably engaged with each other to form an outer skeleton around the vial. The nozzle can include a housing interface configured to slidably engage the nozzle with the housing.

[0008] The dispensing device can include a vial lock that can lock to prevent removal of the vial from the dispensing device and can unlock to allow removal of the dispensing device. In some examples, the vial lock can further include a locking portion for restricting movement of the nozzle relative to the housing (e.g., setting a fully extended position and / or a fully depressed position of the nozzle). In an example where the nozzle is separate from the housing, the vial lock can further prevent separation of the nozzle from the housing when locked and allow separation of the nozzle from the housing when unlocked.

[0009] The dispensing device can include a dosing lock that can lock to prevent movement of the nozzle relative to the housing and thereby prevent administration of the drug. The dosing lock can unlock to allow the nozzle to be depressed into the housing and / or extend out of the housing, thereby allowing administration of the drug. In an example where the nozzle is separate from the housing, the dosing lock can further prevent separation of the nozzle from the housing and / or removal of the vial from the device when locked.

[0010] The dispensing device can include a sensor configured to detect a partial depression of the nozzle, and an electrical circuit configured to lock the dosing lock in response to a signal from the sensor. The sensor can include an optical sensor positioned to view movement of the nozzle relative to the housing. In an example where the nozzle is detachable from the housing, the nozzle can function to deliver the drug with the vial without the housing. The housing can include a dosing lock and a vial lock. The nozzle can be provided with a function capable of engaging and locking the dosing lock and / or the vial lock. The housing can include a sensor for detecting movement of the nozzle. The nozzle can be provided with features on the nozzle that are detectable by a sensor in the housing. The sensor and the features on the nozzle can be positioned and otherwise configured to enable the device to detect a partial depression of the nozzle. The present invention will be more fully understood and appreciated by reading the following detailed description in conjunction with the accompanying drawings.

[0011]

[0012]

Brief Description of the Drawings

[0013]

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DETAILED DESCRIPTION OF THE INVENTION

[0014] Referring to the drawings, the present invention may be a system, method, and / or computer program product. The computer program product may include a computer-readable storage medium having computer-readable program instructions for causing a processor to perform aspects of the present invention. The computer-readable storage medium can be a tangible device that holds and stores instructions for use by an instruction execution device. The computer-readable storage medium can be , for example, but not limited to, an electronic storage device, a magnetic storage device, an optical storage

[0015] device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. A more specific, non-exhaustive list of computer-readable storage media includes portable computer diskettes, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), flash memory, compact disc read-only memory (CD-ROM), digital versatile disc (DVD), Blu-ray disc (BD), magnetic tape, floppy disk, mechanically encoded device such as punch cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing. The computer-readable storage medium can be any appropriate combination of the foregoing. A more specific, non-exhaustive list of examples of computer-readable storage media includes portable computer diskettes, hard disks, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), flash memory, compact disc read-only memory (CD-ROM), digital versatile disc (DVD), One-time programmable memory (EPROM or flash memory), static random access memory (SRAM), portable compact disc read-only memory (CD-ROM ), digital versatile disc (DVD), memory stick, floppy disc, mechanically encoded devices such as punch cards or raised structures in grooves in which instructions are recorded, and any suitable combination of the above. As used herein, a computer readable storage medium should not be construed to be a transient signal per se, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium

[0016] such as light pulses through an optical fiber cable, or an electrical signal transmitted through a wire. The computer-readable program instructions described herein can be downloaded from a computer-readable storage medium to respective computing / processing devices, or to an external computer or external storage device via a network, such as the Internet, a local area network, a wide area network, and / or a wireless network. The network can include copper transmission cables, optical transmission fibers, wireless transmission, routers, firewalls, switches, gateway computers, and / or edge servers. A network adapter card or network interface in each computing / processing device receives the computer- readable program instructions from the network and transmits the computer- readable program instructions for storage in a computer-readable storage

[0017] Computer-readable program instructions for performing the operations of the present invention include assembler instructions, instruction set architecture (ISA) instructions, machine instructions, machine-dependent instructions, microcode, firmware instructions, state-setting data, or source code or object code written in any combination of one or more programming languages including object-oriented programming languages such as Smalltalk, C++, and conventional procedural programming languages such as the "C" programming language or similar programming languages. The computer-readable program instructions can be in the form of a stand-alone software package executed entirely on the user's computer, partially on the user's computer, partially on the user's computer and partially on a remote computer, or entirely on a computer or server. In the latter case, the remote computer can be connected to the user's computer via any type of network including a local area network (LAN) or a wide area network (WAN), or the connection can be made to an external computer (e.g., via the Internet using an Internet service provider). In some embodiments, to carry out aspects of the present invention, for example, an electronic circuit including a programmable logic circuit, a field programmable gate array (FPGA), or a programmable logic array (PLA) can execute the computer-readable program instructions by personalizing the electronic circuit using the state information of the computer-readable program instructions.

[0018] Aspects of the present invention will be described in this specification with reference to the flowchart diagrams and / or block diagrams of methods, apparatuses (systems), and computer program products according to embodiments of the present invention. It will be understood that each block of the flowchart diagrams and / or block diagrams, as well as combinations of blocks in the flowchart diagrams and / or block diagrams, can be implemented by computer-readable program instructions. These computer-readable program instructions may be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing apparatus to create a machine, such that the instructions executed via the processor of the computer or other programmable data processing apparatus implement the functions / operations specified in the singular or plural blocks of the flowchart and / or block diagram. These computer-readable program instructions may be stored in a computer-readable storage medium and can direct a computer, a programmable data processing apparatus, and / or other devices to function in a particular manner, such that the computer-readable storage medium containing the instructions includes a product implementing the aspects of the functions / operations specified in the singular or plural blocks of the flowchart and / or block diagram. The computer-readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other device, causing a series of operational steps to be executed on the computer, other programmable apparatus, or other device to implement a computer-implemented process.

[0019]

[0020] ​​​​​​​​​​​​​​Causing to be generated and executed on a computer, other programmable apparatus, or other devices The instructions may be specified by one or more blocks of a flowchart and / or block diagram to perform the functions / operations specified.

[0021] The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present invention. Each block of the flowchart or block diagram may represent a module, segment, or portion of instructions that include one or more executable instructions for implementing the specified logical function. In some alternative implementations, the functions noted in the blocks may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently depending on the functionality involved, or the blocks may sometimes be executed in the reverse order. It should also be noted that each block of the block diagrams and / or flowchart diagrams, and combinations of blocks in the block diagrams and / or flowchart diagrams, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or by a combination of dedicated hardware and computer instructions. In some alternative implementations, the functions noted in the blocks may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently depending on the functionality involved, or the blocks may sometimes be executed in the reverse order. In some alternative implementations, the functions noted in the blocks may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently depending on the functionality involved, or the blocks may sometimes be executed in the reverse order. For example, two blocks shown in succession may, in fact, be executed substantially concurrently depending on the functionality involved, or the blocks may sometimes be executed in the reverse order. For example, two blocks shown in succession may, in fact, be executed substantially concurrently depending on the functionality involved, or the blocks may sometimes be executed in the reverse order. It should also be noted that each block of the block diagrams and / or flowchart diagrams, and combinations of blocks in the block diagrams and / or flowchart diagrams, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or by a combination of dedicated hardware and computer instructions. It should also be noted that each block of the block diagrams and / or flowchart diagrams, and combinations of blocks in the block diagrams and / or flowchart diagrams, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or by a combination of dedicated hardware and computer instructions. It should also be noted that each block of the block diagrams and / or flowchart diagrams, and combinations of blocks in the block diagrams and / or flowchart diagrams, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or by a combination of dedicated hardware and computer instructions. It should also be noted that each block of the block diagrams and / or flowchart diagrams, and combinations of blocks in the block diagrams and / or flowchart diagrams, can be implemented by a dedicated hardware-based system that performs the specified functions or operations, or by a combination of dedicated hardware and computer instructions.

[0022] Referring back to the drawings, FIG. 1 shows a perspective view of an embodiment of a system according to the present invention, with like reference numerals referring to like parts throughout. FIG. 1 shows an embodiment of a system including a dispensing device 1 00 and a computing device 200. The computing ​The using device 200 can be a smartphone, a portable tablet, a laptop computer, a desktop computer, and any other similar device. FIG. 1 also shows the external components of an embodiment of the dispensing device 100. The dispensing device 100 includes a cylindrical housing 102 having a first closed end 104 and a second closed end 106. The nozzle 108 extends perpendicularly from the surface 104a of the first closed end 104. The second closed end 106 can further include a base plate 106a fixed to the housing 102 by a fastener such as a star screw, thereby preventing unauthorized modification of the housing 102. Other fasteners such as magnetic fasteners, custom "keyed" screws, or similar locking devices are contemplated. The housing 102 further includes a recess 110 having a display screen 112 therein. The display screen can be, for example, a panel display such as a monochrome OLED graphic display, or other LED display. Referring to FIG. 2, a schematic cross-sectional view of an embodiment of the system in the unlocked position, taken along line A, is shown. FIG. 2 shows the internal components of the dispensing device 100 in the unlocked position where the nozzle 108 is depressed. The housing 102 of the dispensing device 100 further includes a first portion 114 and a second portion 116. The first portion 114 of the housing 102 is connected to both the first closed end 104 and the second portion 116. In the illustrated embodiment, the second portion 116 of the housing 102 is also at the second closed end 106 or

[0023] Referring to FIG. 2, a schematic cross-sectional view of an embodiment of the system in the unlocked position, taken along line A, is shown. FIG. 2 shows the internal components of the dispensing device 100 in the unlocked position where the nozzle 108 is depressed. The housing 102 of the dispensing device 100 further includes a first portion 114 and a second portion 116. The first portion 114 of the housing 102 is connected to both the first closed end 104 and the second portion 116. In the illustrated embodiment, the second portion 116 of the housing 102 is also at the second closed end 106 or The first portion 114 of the housing 102 is connected to both the first closed end 104 and the second portion 116. is.

[0024] In the illustrated embodiment, the second portion 116 of the housing 102 is also at the second closed end 106 is connected to the base plate 106a and provides a base for the dispensing device 100. A second part 116 houses a liquid container 118 configured to store a liquid medical composition. In the embodiment shown, the liquid container 118 is cylindrical and is sized to fit efficiently within a similar cylindrical housing 102. An example of a cylindrical liquid container 118 is a thread-sized stock vial.

[0025] To provide access to the pharmaceutical contents of the liquid container 118, the liquid container 118 includes a pump assembly 120. In the embodiment illustrated in FIG. 2, the pump 120 is centrally located within the liquid container 118. The pump assembly 120 is substantially configured and operates as a standard pump assembly used in conventional intranasal spray devices. When pressure is applied to the nozzle 108 toward the surface 104 a of the first closed end 104, the pump assembly 120 propels the liquid medical composition stored within the liquid container 118 through a channel 122 within the nozzle 108, releasing the liquid medical composition from the dispensing device 100. Thus, in the unlocked position, the liquid medical composition can be freely discharged from the dispensing device 100. Referring to FIGS. 3A - 3B, schematic cross-sectional views of embodiments of the system in the locked position along lines A and B, respectively, are shown. In the illustrated embodiment, a first

[0026] portion 114 of the housing 102 further includes a solenoid 124 locking mechanism therein. The solenoid 12 4 operates perpendicular to the movement of the pump assembly 120. In one embodiment, when the solenoid 124 is actuated, the solenoid 124 moves into the path of the nozzle 108, thereby preventing the first portion 114 of the housing 102 from moving relative to the nozzle 108, and thus locking the system in place. When the solenoid 124 is deactivated, the solenoid 124 moves out of the path of the nozzle 108, prevents the complete movement of the nozzle 108 towards the surface 104a of the closed end 104 and prevents the pump assembly body 120 from discharging the liquid medical composition from the dispensing device 100. The solenoid 124 is shown in the unlock position in FIG. 2 and in the locked position in FIGS. 3A - 3B . In an alternative embodiment, the solenoid 124 can include a fixture such as a U - clip that blocks the path of the nozzle 108 and interrupts the movement of the pump assembly body 120.

[0027] Continuing to refer to FIGS. 3A - 3B, in the illustrated embodiment, the solenoid 124 is actuated in response to an electrical signal sent from a processor such as a printed circuit board 126. As shown in FIGS. 3A - 3B, the printed circuit board 126 is disposed within the second portion 1 16 of the housing 102 and towards the second closed end 106. The printed circuit board 126 is operatively connected to a battery 128 that is also disposed within the second portion 116 at the second closed end 106 and is powered by the battery 128. The battery 128 can be a rechargeable lithium - ion battery or a similar type of power source.

[0028] In an alternative embodiment, the locking mechanism is a motor assembly 300. FIGS. 7A - 8C show various views of one embodiment of the locking mechanism of the motor assembly 300. First, referring to FIG. 7 A, a top perspective view of the motor assembly 300 is shown in the locked position. The motor assembly 300 includes a motor 302 connected to a first gear 304 disposed within an opening 306 of an internal gear 308. The internal gear 308 includes a central lock 3 10 through which a keyway 312 extends. Similar to the embodiment where the locking mechanism is the solenoid 124 (FIGS. 3A - 3B) , the motor assembly 300 interrupts the movement of the pump assembly 120 or locks it in another way. In the embodiment shown in FIG. 7A, the shaft 314 of the pump assembly 120 extends through the central lock 310 of the internal gear 308. To facilitate locking, there is one or more keys 316 protruding from the shaft 314 of the pump assembly 120. The key 316 is configured to slide or fit into the keyway 312 of the central lock 310. In the embodiment shown in FIG. 7A, the key 316 rests on the central lock 310 and sliding into the keyway 312 is prevented. Thus, the nozzle 108 attached to the pump assembly 120 is not compressible when the key 316 is not aligned with the keyway 312. In the embodiment shown in FIG. 7A, the shaft 314 of the pump assembly 120 extends through the central lock 310 of the internal gear 308. To facilitate locking, there is one or more keys 316 protruding from the shaft 314 of the pump assembly 120. The key 316 is configured to slide or fit into the keyway 312 of the central lock 310. In the embodiment shown in FIG. 7A, the key 316 rests on the central lock 310 and sliding into the keyway 312 is prevented. Thus, the nozzle 108 attached to the pump assembly 120 is not compressible when the key 316 is not aligned with the keyway 312.

[0029] Next, referring to FIGS. 7B - 7C, side and top views of the motor assembly 300 in the unlocked position are shown. From the locked position shown in FIG. 7B, the motor 302 is actuated by an electrical signal from the printed circuit board 126, and the printed circuit board 126 rotates the gear 304, thereby rotating the internal gear 308. The opening 306 of the internal gear 308 can only rotate in either direction until the internal gear 308 catches on the gear 304, thus restricting the rotation of the internal gear 308. When the internal gear 308 rotates, the lock 310 and the keyway 312 also rotate. The internal gear 308 rotates until it reaches the unlocked position shown in FIG. 7B. In the unlocked position, the key 316 of the shaft 314 of the pump assembly 120 aligns with the keyway 312 extending through the lock 310. When the motor assembly 300 reaches the unlocked position, the nozzle 108 can be compressed. When the nozzle 108 is compressed, as shown in FIG. Next, referring to FIGS. 7B - 7C, side and top views of the motor assembly 300 in the unlocked position are shown. From the locked position shown in FIG. 7B, the motor 302 is actuated by an electrical signal from the printed circuit board 126, and the printed circuit board 126 rotates the gear 304, thereby rotating the internal gear 308. The opening 306 of the internal gear 308 can only rotate in either direction until the internal gear 308 catches on the gear 304, thus restricting the rotation of the internal gear 308. When the internal gear 308 rotates, the lock 310 and the keyway 312 also rotate. The internal gear 308 rotates until it reaches the unlocked position shown in FIG. 7B. In the unlocked position, the key 316 of the shaft 314 of the pump assembly 120 aligns with the keyway 312 extending through the lock 310. When the motor assembly 300 reaches the unlocked position, the nozzle 108 can be compressed. When the nozzle 108 is compressed, as shown in FIG. When the motor assembly 300 reaches the unlocked position, the nozzle 108 can be compressed. When the nozzle 108 is compressed, as shown in FIG. ​​As shown in 7C, the key 316 on the shaft 314 of the pump assembly 120 slides within the keyway 312 of the lock 310 When the nozzle 108 is released, the key 3 16 on the shaft 314 slides out of the keyway 312, and the internal gear 308 may be rotated back to the locked position shown in FIG. 7A as well.

[0030] Next, referring to FIGS. 8A - 8C, various perspective views of the first portion 114 and the second portion 116 of the housing 102 with the motor assembly 300 are shown. In the illustrated embodiment, the first portion 114 of the housing 102 includes the pump assembly 120, the printed circuit board 126, and a battery 128 (not shown), and the second portion 116 of the housing 102 includes a liquid container 118 (not shown). First, referring to FIG. 8B, a side view of the first portion 114 of the housing 102 and the second portion 116 of the housing 102 in the unlock position is shown. The first portion 114 of the housing 102 has an aperture 318 along the outer periphery of its bottom surface 3 20. A disk 324 stacked on the bottom surface 320 of the first portion 114 of the housing 102 has a notch 326 along the outer periphery of the disk 324. The notch 326 is configured to align with the aperture 318 of the bottom surface 320 of the first portion 114. Continuing to refer to FIG. 8B, the motor 302 of the motor assembly 300 includes a second gear 322 on the side opposite the first gear 304 of the motor 302 . The second gear 322 is used to rotate the disk 324 on the bottom surface 320 of the first portion 114 .

[0031] Next, referring to FIG. 8A, the second portion 116 of the housing 102 is the second portion 116 It includes a plurality of L-shaped flanges 328 extending from the upper surface 330. The L-shaped flange 328 is , configured to fit through the aperture 318 in the bottom surface 320 of the first portion 114 and the notch 32 6 of the disk 324. In the unlocking position shown in FIG. 8B, the L-shaped fl ange 328 is aligned with the aperture 318 in the bottom surface 320 of the first portion 114 and the notch 326 of the disk 324. Accordingly, the second portion 116 can be pulled off from the first portion 114 of the housing 102.

[0032] To reach the locked position shown in FIG. 8C, when the motor 302 receives an electrical signal from the printed circuit board 126 , it rotates the second gear 322, which rotates the disk 324 . The disk 324 rotates such that the notch 326 is no longer aligned with the L-shaped flange 328 . Accordingly, the L-shaped flange 328, and thus the second portion 116 of the housing 102, cannot be removed from the first portion 114 . In some embodiments, the disk 324 is spring loaded such that the locked position is the default position of the disk 324 .

[0033] The circuit described for operating the locking mechanism can also be connected to one or more signal LEDs 130 on the housing 102, as shown in FIG. 1 . In one embodiment, the signal LED 130 lights up when the solenoid 124 is actuated and the dispensing device 100 is in the locked position . In an alternative embodiment, the signal LED 130 lights up red when the solenoid 124 is actuated and the dispensing device 100 is in the locked position, and lights up when the solenoid 124 is stopped or otherwise deactivated and the dispensing device 100 is in the unlocked position or other non-operating state. Sometimes, it can be lit in green.

[0034] The circuit is also connected to a screen 112 within a recess 110 of the housing 102 and supplies power to the screen 112. In the embodiments shown in FIGS. 2 and 3A, the recess 110 is surrounded by a lens 132. The lens 132 protects the screen 112 from liquids, debris, and other contaminants while still allowing the user to clearly view the screen 112. In the illustrated embodiment, the lens 132 is on the same plane as the housing 102, enabling the user to easily operate the dispensing device 100. In one embodiment the lens 132 can include a biosensor inside. In an alternative embodiment as shown in FIG. 1, the biosensor 134 is at a separate location along the housing 102. The biosensor 134 can include a fingerprint scanner, an iris scanner, a heart rate detector, etc. The lens 132 can also have a touch screen function so that the user can enter a passcode on a keypad displayed on the screen 112. The biosensor 134 and the passcode element provide an additional security layer for accessing the drug by identifying an individual using the device and sending a signal to the printed circuit board 126 to move the solenoid 124 to the unlocked position. In some embodiments, the dispensing device 100 can further include a photocell 136 disposed within the housing and connected to the circuit. The photocell 136 detects the light state inside the device. Thus, the photocell 136 can detect when the dispensing device 100 is illegally modified or opened. The lens 132 can also have a touch screen function so that the user can enter a passcode on a keypad displayed on the screen 112. The biosensor 134 and the passcode element provide an additional security layer for accessing the drug by identifying an individual using the device and sending a signal to the printed circuit board 126 to move the solenoid 124 to the unlocked position. 134 and the passcode element provide an additional security layer for accessing the drug by identifying an individual using the device and sending a signal to the printed circuit board 126 to move the solenoid 124 to the unlocked position. 134 and the passcode element provide an additional security layer for accessing the drug by identifying an individual using the device and sending a signal to the printed circuit board 126 to move the solenoid 124 to the unlocked position. 134 and the passcode element provide an additional security layer for accessing the drug by identifying an individual using the device and sending a signal to the printed circuit board 126 to move the solenoid 124 to the unlocked position.

[0035] In some embodiments, the dispensing device 100 can be disposed within the housing and further include a photocell 136 connected to the circuit. The photocell 136 detects the light state inside the device. Thus, the photocell 136 can detect when the dispensing device 100 is illegally modified or opened. The photocell 136 detects the light state inside the device. Thus, the photocell 136 can detect when the dispensing device 100 is illegally modified It can detect whether it has been tampered with or destroyed. In other embodiments, the dispensing device 100 may further include a drug sensor 138 connected to a circuit that monitors the level of the drug in the liquid container 118. Thus, the drug sensor 138 can send a signal to the printed circuit board 126 when the liquid container 118 is empty or when the remaining amount of the drug is low.

[0036] The pump assembly 120 may further include a tactile switch 140. The tactile switch 140 operates as a momentary switch that is activated when the pump assembly 120 is fully activated. The tactile switch 140 is operatively coupled to the printed circuit board 126 where the full activation of the pump assembly 120 is recorded. The circuit from the printed circuit board 126 further extends to a real-time clock chip 142. The real-time clock chip 142 can be used to provide the date and time for display on the screen 112. As will be described later, the real-time clock chip 142 can be used in combination with the solenoid 124 and the tactile switch 140 to lock the dispensing device 100.

[0037] Referring now to FIGS. 4-6, a diagrammatic representation of an embodiment of the method according to the present invention is shown. During use, the components within the dispensing device 100 communicate with a web platform accessible on the computing device 200 to control the dispensing of the drug. The printed circuit board 126 communicates with the computing device 200 using Bluetooth Low Energy (BLE) as a wireless protocol for communication. ​​​​​energy) can be utilized. Therefore, the printed circuit board 126 can be programmed from the computing device 200. For example, a healthcare provider can , via a terminal on the computing device 200, adjust settings on the web platform. The healthcare provider can indicate the dosing frequency of the drug stored in the liquid container 118 and the minimum period between doses. Next, this information is sent to the printed circuit board 126. The printed circuit board 126 calculates the dosing frequency based on feedback from the tactile switch 140 and determines the period between doses based on data from the real-time clock chip 142.

[0038] In addition to programming the dispensing device 100, the web platform may be utilized by a healthcare provider to view status information from the dispensing device 100. For example, dosing time, lock status, unauthorized change warnings, and remaining dose amounts are information that can be pushed from the dispensing device 100 to the web platform via a wireless network and / or cellular data, which is ultimately accessible by the healthcare provider at a terminal on the computing device 200. Further, the web platform can also include a calendar interface or other scheduling format for tracking the patient's dosing amounts and prescription plan. Therefore, the dispensing device 100, the healthcare provider's computing device 200, and the patient's smartphone (described below) can exchange status information via a GSM or some other similar digital cellular network.

[0039] The biosensor 134 may be programmed by the patient in the presence of a healthcare provider. For example, the healthcare provider can adjust settings on a web platform to enable programming of the biosensor 134. The biosensor 134 can then scan the patient's fingerprint and assign, for example, a patient ID to a specific dispensing device 100. Once programmed, the biosensor 134 requires an ID check before the dispensing device 100 can be used.

[0040] When the dispensing device 100 is programmed via the web platform on the healthcare provider's computing device 200, the patient can use the dispensing device 100. To access the medication, the patient first proves their ID by activating the biosensor 134, such as by placing a finger on the biosensor 134 for fingerprint scan verification. Once the patient's ID is verified, the patient can self-administer the first dose of the medication.

[0041] In an alternative embodiment, the patient's smartphone or other computing device can act as a second layer of authentication for using the dispensing device 100. For example, the patient can access a patient interface on a web platform on their smartphone. At the time of dosing, the patient may be required to authenticate themselves via the smartphone. For example, the patient can complete authentication by unlocking their phone via a passcode or fingerprint sensor. In another embodiment, the hel... ​​​​​​​​​​​​​​The healthcare provider can send a temporary or one-time PIN code from the healthcare provider interface of the web platform to the patient interface of the web platform. Accordingly, the patient can access the web platform on their smartphone, search for the PIN code, and enter the PIN code on the dispensing device 100 to unlock it. To administer the first dose, the patient holds the dispensing device 100 such that the nozzle 108 is close to or partially within the nostril and applies pressure towards the surface 104a of the first closed end 104 on the nozzle 108. The pump assembly 120 releases the drug from the nozzle 108 so that the patient can inhale the drug. When the pump assembly 120 is actuated, the tactile switch 140 is also triggered. The tactile switch 140 sends a signal indicating that the pump assembly 120 has been actuated to the printed circuit board 126. At the same time, the printed circuit board 126 associates the signal from the tactile switch 140 with the time provided by the real-time clock chip 142.

[0042] When the healthcare provider sets the minimum period between doses, the receipt of the signal from the tactile switch 140 also causes the printed circuit board 126 to actuate the solenoid 124. The solenoid 124 moves into the path of the nozzle 108, thereby preventing the patient from administering the next dose of the drug. The dispensing device 100 remains in the locked position where the solenoid 124 blocks the actuation of the nozzle 108 until the minimum period has elapsed. The printed circuit board 126 is a real

[0043] ​​​​​​​​​​​​Time can be monitored using the data received from the time clock chip 142. After the shortest period of time has elapsed after the activation of the tactile switch 140, the printed circuit board 126 triggers to retract the solenoid 124, thereby enabling the patient to fully depress the nozzle 108 to administer the next dose. Thereafter, the locking process is repeated.

[0044] In an embodiment where one or more signal LEDs 130 are disposed on the housing 102, the signal LED lights up red when the solenoid 124 is in the path of the nozzle 108, indicating that no dose is being administered, and lights up green when the solenoid 124 is retracted, informing the patient that a subsequent dose is available. Since the printed circuit board 126 can communicate wirelessly with the computing device 200, a signal from the printed circuit board 126 can be transmitted to the computing device 200 to alert the patient that the next dose is available. In an alternative embodiment, the drug sensor 138 can send a signal indicating that the liquid container 118 is empty or that the remaining amount of the drug is low to the printed circuit board 126 and ultimately to the computing device 200. This alerts the patient to initiate the process of refilling the prescription.

[0045] In an embodiment where the housing 102 includes a photocell 136, the photocell 136 can be configured to send a signal to the printed circuit board 126 when it detects light exceeding a programmed threshold. The printed circuit board 126 can be programmed to send a signal to a computing device 200 accessible by a healthcare provider. The signal can appear as a warning on the web platform to notify the healthcare provider that the dispensing device 100 has been tampered with. In an additional embodiment, the print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan. In an additional embodiment, the print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan. The print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan. The print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan. The print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan. The print circuit board 126 can be programmed to send data to a computing device 200 that is operated by the healthcare provider and / or the patient. The healthcare provider and the patient can then access this data to improve compliance with the treatment plan.

[0046] Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components. Figures 9 - 15 and Figures 17, 18A and 18B each show two additional embodiments of dispensing devices 400, 600. The components and / or design strategies of the various dispensing device embodiments 100, 400, 600 are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. For example, although not explicitly shown, the additional embodiments 400, 600 can include signal LEDs 130, lenses 132, screws 112, photocells 136, drug sensors 138, tactile switches 140, real - time clocks 142, any combination thereof, or variations thereof. Similarly, the additional embodiments 400, 600 can include appropriate electrical circuitry and mechanical structures to support such components.

[0047] One of the shown embodiments 400 includes sensors 442, 444, 446 (Figure 14B) and visual features 490, 492, 494 (Figure 10) for detecting the depression level of the nozzle 460. Such sensors and visual features are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. One of the shown embodiments 400 includes sensors 442, 444, 446 (Figure 14B) and visual features 490, 492, 494 (Figure 10) for detecting the depression level of the nozzle 460. Such sensors and visual features are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. One of the shown embodiments 400 includes sensors 442, 444, 446 (Figure 14B) and visual features 490, 492, 494 (Figure 10) for detecting the depression level of the nozzle 460. Such sensors and visual features are combinable or interchangeable as would be understood by one of ordinary skill in the relevant art in accordance with the teachings of this disclosure. As will be understood by those skilled in the art, Embodiment 1 of the other dispensing devices shown herein can be incorporated into 00, 600 or variations thereof. When the nozzle is partially depressed over a long period of time and / or when the user performs a partial depression and returns the nozzle to the fully extended position, the dispensing devices 100, 400, 600 can be configured to lock the nozzles 108, 460, 660. This prevents the user from attempting to avoid the security of the dispensing devices 100, 400, 600 and administering multiple partial doses

[0048] The dispensing devices 100, 400, 600 can further include a ratchet-type dosing lock such as the dosing lock 420 shown in FIG. 13 and the dosing lock 620 shown in FIG. 18A. The shown dosing locks 420, 620 are in the locked position of the dosing locks 420, 620, allowing the nozzles 460, 660 to return to the fully extended position when the nozzles are partially depressed and preventing further depression of the nozzles by ratchet action. Alternatively, the ratchet can be shaped to allow the nozzle to be depressed and prevent extension of the nozzle. Each design has several advantages. For example, the lockout ratchet (which prevents depression of the nozzle) immediately prevents further dosing of the drug when the lock is engaged, which can be a desirable feature when preventing overdosage of the drug is the main concern. The dosing forced ratchet (which prevents extension of the nozzle) prevents partial depression from occurring when the lock is engaged, but can allow dosing to be completed. This can be a desirable feature when preventing small doses of the drug is the main concern ​​​​​​​​​​​​ This may be a desirable feature when

[0049] Additional embodiments 400, 600 include a computing device such as the computing device 200 shown in FIG. One or more computing devices, including any other computing device disclosed herein and / or a device as understood by one of ordinary skill in the relevant art following the teachings of this disclosure. The present invention is capable of functioning in conjunction with one or more computing devices, such as The dispensing devices 400, 600 can be used to carry out the methods shown in Figures 4 to 6. The distribution devices 400 and 600 communicate with each other via Wi-Fi, Bluetooth, cellular, etc. As a computing device (e.g., the computing device 200 shown in FIG. ) directly and / or remotely to control (lock) the distribution devices 400, 600. Lock / unlock, load biometrics / load new nasal spray device / schedule medication The distribution devices 400 and 600 can Communicating to the device 200 if the patient has missed a dose or tampered with the device The dispensing device 400, 600 can then alert the physician via a push notification. Generate output to remind a patient when to take medication (e.g., by a physician) The output can be configured to be transmitted to another device, such as, but not limited to, the patient's mobile phone. Any of the above known techniques may be used to provide a light, display, sound or other alert or communication to a device. The distribution devices 400, 600 may be configured as distribution devices. Further monitor patient usage at the 400 and 600 hospitals and collect information / data on patient usage from the database. Directly via a display or other means on the vises 400, 600, it can be provided to the computing device 200 to notify the doctor regarding the patient's medication compliance. The dispensing devices 400, 600 can have a timed lockout (pre-set by the doctor) and / or a scheduled lockout. The timed lockout can be pre-set by an authorized user (e.g., a doctor) . The scheduled lockout can be remotely set and / or edited via a web platform (or other network-connected platform accessible via the doctor's computing device) .

[0050] Both options still require the patient's authentication information to unlock the device . This can be done using a biometric scanner on the device or, in the future, using the biometric (fingerprint / face / iris) scanning function on the user's mobile phone .

[0051] Typically, the dispensing devices 400, 600 provide safe drug delivery and include disposable parts with a drug and reusable able exoskeleton or housing components. The exoskeleton secures the disposable part containing the drug / drugs and controls how and when the substance is dispensed. In some embodiments, the exoskeleton can secure (e.g., encapsulate) a standardized nasal spray device 500. The exoskeleton can lock and unlock the nozzle movement of the standardized nasal sprayer 500. The lock of the devices 400, 600 (for drug administration) and The call and unlock can be remotely (Wi-Fi / BT) controlled and / or configured via the mobile phone application and the web platform as prescribed by the doctor / physician. The nozzle can include an outer portion of the lock that interacts with the exoskeleton locking mechanism. / or can be configured. The nozzle can include an outer portion of the lock that interacts with the exoskeleton locking mechanism. The standardized nasal spray device / vial 500 can be inserted into the exoskeleton from locations including, but not limited to, the top (see the dispensing device 400 shown in FIGS. 9-15) and the bottom (see the dispensing device 600 shown in FIGS. 17, 18A, and 18B).

[0052] The top-loading dispensing device 400 can include a nozzle 460 that can be detached from the housing 402. The nozzle 460 can be disposable and can be attached to a standardized nasal sprayer. Alternatively, a custom disposable vial can be constructed that includes a nozzle portion that follows the design strategy of the disposable nozzle 460. Since the nozzle 460 of the top-loading dispensing device 400 is disposable, the nozzle 460 can be discarded and / or cleaned separately from the reusable housing 402 of the device 400, thereby potentially providing better hygiene compared to the bottom-loading dispensing device 600. The bottom-loading device 600 can be configured to receive a standard vial 500 without the need for a dedicated nozzle 460, and thus can potentially be more convenient and / or cost-saving compared to the top-loading device 400. The nozzle 460 can be disposable and can be attached to a standardized nasal sprayer. Alternatively, a custom disposable vial can be constructed that includes a nozzle portion that follows the design strategy of the disposable nozzle 460. The nozzle 460 of the top-loading dispensing device 400 is disposable, so the nozzle 460 can be discarded and / or cleaned separately from the reusable housing 402 of the device 400, Thereby potentially providing better hygiene compared to the bottom-loading dispensing device 600. The bottom-loading device 600 can be configured to receive a standard vial 500 without the need for a dedicated nozzle 460, And thus can potentially be more convenient and / or cost-saving compared to the top-loading device 400. Since the nozzle 460 of the top-loading dispensing device 400 is disposable, the nozzle 460 can be discarded and / or cleaned separately from the reusable housing 402 of the device 400, Thereby potentially providing better hygiene compared to the bottom-loading dispensing device 600. The bottom-loading device 600 can be configured to receive a standard vial 500 without the need for a dedicated nozzle 460, And thus can potentially be more convenient and / or cost-saving compared to the top-loading device 400. The bottom-loading device 600 can be configured to receive a standard vial 500 without the need for a dedicated nozzle 460, And thus can potentially be more convenient and / or cost-saving compared to the top-loading device 400. The bottom-loading device 600 can be configured to receive a standard vial 500 without the need for a dedicated nozzle 460, and thus can potentially be more convenient and / or cost-saving compared to the top-loading device 400. It can be more convenient and / or cost-saving compared to the top-loading device 400.

[0053] The dispensing devices 400, 600 are for detecting nozzle movement and unauthorized device modification sensors (e.g., optical / imaging), and for detecting a pattern of fine movement for detecting the unique movement patterns of different users when handling the devices 400, 600 and / or a drug neutralizer (e.g., powder or sponge) for chemically neutralizing the drug released from the internal vial 500. As discussed above and understood by those skilled in the art , one or more of these features can be combined and / or exchanged with the features of the device 100 .

[0054] Here, the details of each additional embodiment 400, 600 are discussed in relation to the drawings.

[0055] FIG. 9 is a side view of a top-loading dispensing device 400 according to the present invention. The dispensing device 400 includes a housing 402 and a nozzle 460, which together form an outer skeleton that (at least partially) surrounds and secures the vial 500 (FIG. 10).

[0056] The nozzle 460 and the vial 500 shown in FIG. 10 are snap-engaged together. The no zzle 460 is provided with a housing interface 480 that snap-engages onto the vial 500, thereby enabling the nozzle 460 to be pushed down and providing features for locking the combined nozzle 460 and vial 500 within the housing 402. The combined nozzle 460 and vial 500 can function to deliver the drug both with and without the housing 402, whether they are fitted during manufacture or after manufacture, thereby enabling healthcare providers to ​ It becomes possible to select whether the drug in the housing 402 is provided when a specific patient is given a specific drug. Since the nozzle 460 is not integrated with the housing 402, the nozzle 460 can be discarded or cleaned separately from the housing 402, which potentially results in a more hygienic product compared to a reusable dispensing device having an integrated nozzle. Furthermore, the opening 412 through which the nozzle 460 passes and slides during operation is the same opening through which the vial is removed, eliminating the need for a second opening for vial removal. When there is no second opening for vial removal, the cover 418 of the housing 402 can have a smoother, and thus potentially more tamper-resistant, stronger outer surface. The device 400 is oriented vertically about the longitudinal axis L-L that intersects the orthogonal planes A and B. The housing 402 has a first upper end 404 having a first upper surface 404a that is orthogonal to the longitudinal axis L-L and the planes A and B.

[0057] The housing 402 has a second lower end 406 having a second bottom surface 406b that is substantially parallel to the first surface 404a. The nozzle 460 extends vertically from the upper surface 404a of the housing 402. The housing 402 has an opening 412 in the upper surface 404a, and the nozzle 460 is positioned within the opening 412 and has a housing interface 480 configured to slidably engage the housing 402. As shown, when the nozzle 460 is slidably engaged with the housing 402 and the nozzle 460 is unlocked, the nozzle 460 fully extends as shown in FIG. 9. The housing 402 has an opening 412 in the upper surface 404a, and the nozzle 460 is positioned within the opening 412 and has a housing interface 480 configured to slidably engage the housing 402. The housing 402 has an opening 412 in the upper surface 404a, and the nozzle 460 is positioned within the opening 412 and has a housing interface 480 configured to slidably engage the housing 402. The housing 402 has an opening 412 in the upper surface 404a, and the nozzle 460 is positioned within the opening 412 and has a housing interface 480 configured to slidably engage the housing 402. As shown, when the nozzle 460 is slidably engaged with the housing 402 and the nozzle 460 is unlocked, the nozzle 460 fully extends as shown in FIG. 9. As shown, when the nozzle 460 is slidably engaged with the housing 402 and the nozzle 460 is unlocked, the nozzle 460 fully extends as shown in FIG. 9. It is translatable from the set position to the fully depressed position, and when fully depressed at the position, the bottom surface 470 of the engagement ring 466 of the nozzle 460 is the same as the depressed position of the nozzle 108 with respect to the housing surface 104a shown in FIG. 2, and approaches the upper surface 404a of the housing 40 2.

[0058] As used herein, the terms "fully extended position" and "fully depressed position" refer to the two extremes between which the nozzle moves for the intended purpose of providing a dosage.

[0059] The housing 402 can further include a biosensor 408 that can function similarly to the biosensor 134 described elsewhere herein. For example, a fingerprint scan on the sensor 40 8 can be used by the electrical circuitry of the device 400 to determine whether to unlock the dosing lock. Additionally or alternatively, a fingerprint scan on the sensor (e.g., by a physician) can be used by the electrical circuitry of the device 400 to determine whether to unlock the vial. The housing 402 can include a finger cover 410. The finger cover 410 can include a display and / or the display can be positioned elsewhere on the housing 402.

[0060] The display can function in the same way as the display 112 described elsewhere in this specification.

[0061] The device 400 can further include a removable nozzle cap 461.

[0062] FIG. 10 is a side view of the nozzle 460 engaged with the pharmaceutical vial 500 in the same orientation as FIG. 9. Referring collectively to FIGS. 9 and 10, the assembled nozzle 460 and vial 500 in FIG. 10 can be removed from the housing 402 in FIG. 9 without damaging the housing 402, preferably without damaging the nozzle 460. During use, the nozzle 460 and vial 500 are interchangeable and preferably disposable. The housing 402 can be reloaded with a new nozzle 460 and vial 500 assembly. The pharmaceutical vial 500 can be loaded through the opening 412 in the upper surface 404a of the housing 402. Thus, the housing 402 has a chamber 414 (FIG. 13) sized to receive the pharmaceutical vial 500, and the chamber 414 is accessible through the opening 412 in the upper surface 404a of the housing 402. The outer surface of the housing 402 can completely eliminate fasteners or other externally accessible means for releasing the device 400 when assembled to the nozzle 460. In some applications, it may be desirable to provide an outlet 419 to allow the liquid discharged from the vial 500 within the device 400 to exit the device 400. In other applications, it may be desirable to capture the liquid discharged from the vial 500 within the device 400 (e.g., a sponge within the chamber 414 shown in FIGS. 14A and 14B). FIGS. 11A and 11B are orthogonal side views of the nozzle 460 and vial 500.

[0063] When assembled to the nozzle 460, the outer surface of the housing 402 can completely eliminate fasteners or other externally accessible means for releasing the device 400. In some applications, it may be desirable to provide an outlet 419 to allow the liquid discharged from the vial 500 within the device 400 to exit the device 400. In other applications, it may be desirable to capture the liquid discharged from the vial 500 within the device 400 (e.g., a sponge within the chamber 414 shown in FIGS. 14A and 14B). In other applications, it may be desirable to capture the liquid discharged from the vial 500 within the device 400 (e.g., a sponge within the chamber 414 shown in FIGS. 14A and 14B). (e.g., a sponge within the chamber 414 shown in FIGS. 14A and 14B).

[0064] FIGS. 11A and 11B are orthogonal side views of the nozzle 460 and vial 500. Here, FIG. 11A shows the left side of the assembly shown in FIG. 10, and FIG. 11B shows the right side of the assembly shown in FIG. 10 FIG. 12 is a view of the assembly shown in FIGS. 10, 11A, and 11B with the nozzle 460 removed. Referring collectively to FIGS. 10, 11A, 11B, and FIG. 1 2, the nozzle 460 includes a conical portion 462, an engagement ring 466, a housing interface 480, a spring 478, and a retaining ring 476. Preferably the conical portion 462, the engagement ring 466, and the housing interface 480 are molded as a single-piece handle portion 463. Alternatively, at least one of the conical portion 462, the engagement ring 466, and the housing interface 480 can be molded individually and attached together to form the handle portion 463. The conical portion 462 has a dispensing end 472, a base end 474, and a fluid passage 464 that extends along the longitudinal axis L-L through the base end 474 and the dispensing end 474. The engagement ring 4 66 extends radially from the base end 474 of the conical portion, provides an upper surface 468, and against this upper surface 46 8, the user can provide a force to push down the nozzle 460. The bottom surface 470 of the engagement ring 4 66 faces away from the dispensing end 472. When the device 400 is set up to prevent further pushing down of the housing interface 480 into the housing 402

[0065] the bottom surface 470 can be further configured to contact the upper surface 404a of the housing 402, for example, by molding or in other ways. The housing interface 480 has an outer surface 482 that surrounds the longitudinal axis L-L and an upper end 484 attached to the engagement ring 466 66 extends radially from the base end 474 of the conical portion, provides an upper surface 468, and against this upper surface 46 8, the user can provide a force to push down the nozzle 460. The bottom surface 470 of the engagement ring 4 66 faces away from the dispensing end 472. When the device 400 is set up to prevent further pushing down of the housing interface 480 into the housing 402 the bottom surface 470 can be further configured to contact the upper surface 404a of the housing 402, for example, by molding or in other ways. The housing interface 480 has an outer surface 482 that surrounds the longitudinal axis L-L and an upper end 484 attached to the engagement ring 466 axis L-L and an upper end 484 attached to the engagement ring 466 axis L-L and an upper end 484 attached to the engagement ring 466 and an open lower end 486, and a passage 488 extending between the upper end 484 and the lower end 486. The vial 500 and the nozzle 460 assembled during manufacture are pre-assembled so that no further assembly is required on the part of the healthcare provider, thus providing further convenience.

[0066] The nozzle 460 can first place the retaining ring 476 and the spring 478 on the vial 500 and then slide the housing interface 480 over the spring and the retaining ring 476 to fit it onto the vial 500. The housing interface 4 80 moves over the vial 500 and snaps under the ridges on the vial, and has a flexible hook 481 extending to engage and fix the nozzle 460 to the vial 500. The inner sides of the conical portion 462 and the engagement ring 466 can be shaped to fit over the vial nozzle. The vial and nozzle assembly can further include an adapter or a vial nozzle cover that assists in mating the nozzle 460 to the vial 500. In this way, the nozzle 460 can be fitted onto existing standard-sized vials. Alternatively, the vial 500 and the nozzle 460 can be specially designed together and / or integrally.

[0067] The nozzle 460 includes features that cooperate with the housing 402 to control the dispensing of the drug within the vial 500, as will be described in more detail below. As shown in FIGS. 10, 11A and 11B, the drug can also be dispensed when the nozzle 460 and the vial assembly are outside the housing. This is intended for the drug to be adjusted during use ​​​​​​ Whether or not it is depicted, it can be similarly packaged, which increases convenience and potentially reduces costs.

[0068] Referring to FIG. 10, the housing interface includes openings 490, 492, 494 in the outer surface 482 that assist in detecting a partial depression of the nozzle 460. When the nozzle 460 is depressed on the vial 500, the movement of the housing interface 480 relative to a portion of the nozzle 460, such as the retaining ring 476, becomes visible through the openings 490, 492, 494. The housing 402 can include one or more sensors that detect the movement of a portion of the nozzle 460 (e.g., the retaining ring 476) over the openings 490, 492, 494. FIG. 10 shows three openings 490, 492, 494 that are positioned such that three positions of the depression of the nozzle 460 can be detected. The housing interface 480 can include one or more such openings 490, 492, 494 to serve the same purpose, where the maximum number of openings is limited by physical design constraints as understood by those skilled in the art in accordance with the teachings of the present disclosure. Preferably, the outer surface 482 of the housing interface 480 provides a high contrast Moves to cover and not cover the view of the optical sensor. The optical sensor detects the movement of the upper and lower openings 490, 494 on the housing interface 480 in order to check the movement at the start and end of dosing. If dosing has started but the bottom has not been pressed, the dosing lock 420 engages (described in more detail in relation to FIGS. 13 and 14B). As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402. FIGS. 13 and 14B show the housing dosing lock 420 that engages the notch 496 on the nozzle 460. Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case,

[0069] As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402. As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402. As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402. As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402. As shown in FIGS. 10 and 11A, the housing interface 480 has a notch 496 for locking the depression of the nozzle 460 into the housing 402, i.e., for preventing the user from receiving a dose. Two notches 496 are shown. The lower notch is positioned to maintain the nozzle in a fully extended position when the housing interface 480 is slidably engaged with the housing 402.

[0070] FIGS. 13 and 14B show the housing dosing lock 420 that engages the notch 496 on the nozzle 460. FIGS. 13 and 14B show the housing dosing lock 420 that engages the notch 496 on the nozzle 460.

[0071] Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, Referring collectively to FIGS. 10, 11A, 13, and 14B, during the intended use of the device 400, the user allows the nozzle to return to a fully extended position after each administration of the drug, and when the administration is complete, the nozzle 460 is locked in the fully extended position by engaging the lower notch with the dosing lock 420. However, the user may inadvertently or intentionally partially depress the nozzle at the same time as the dosing lock 420 of the housing 402 (see FIGS. 13 and 14B) engages. In this case, When the upper notch engages with the dosing lock 420 and the nozzle is partially depressed it is positioned to prevent further depression of the nozzle. At least the upper notch has an angled shape and allows the vial lock to slide downward away from the notch 496 and the nozzle 46 0 to extend further from the housing 402 despite the nozzle 460 being prevented from further depression. In use, when the upper notch is engaged by the vial when the depressing force is removed from the nozzle 460 and the nozzle 460 is locked the spring 478 pushes the nozzle 460 towards a fully extended position outside the housing 402. Thus, the dosing lock 420 can slide from the upper notch to the lower notch. One upper notch is shown but the housing 402 can further include additional angled notches positioned to engage the vial lock when the nozzle 460 is depressed to multiple partial depression positions . Thus, the angled notch can function as a ratchet and allow movement of the nozzle 460 in one direction when the vial lock is engaged . The number and position of the angled notches can be determined by physical design constraints as understood by those skilled in the art . Thus, the ratchet operation of the dosing lock 420 allows the user to administer a dose (by depressing the nozzle 460), then slowly release the nozzle 460 towards the extended position, stop just before reaching the fully extended position and engaging the lower notch 496 (see also FIG. 13), and then when attempting to depress the nozzle 460 again, the dosing lock 420

[0072] ​​ It is possible to lock out a user attempting to break it.

[0073] Referring to FIG. 11B, the housing interface 480 can further include a vial lock opening 4 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure. 98. The vial lock opening 498 can be shaped, sized, and otherwise configured to engage a vial lock 430 (see FIGS. 13 and 14B) of the housing 402. When the vial lock extends into the opening 498, engagement of the vial lock with the lower ledge 499 of the opening 498 can prevent the nozzle from being pulled out of the housing 402. The opening 498 can be sized such that the vial lock can freely pass through the opening 498 when the nozzle 460 is pushed down to deliver the drug. The opening can further be sized such that the vial lock engages the upper ledge 497 of the opening 498 and sets the fully extended position of the nozzle 460. Alternatively, the fully extended position of the nozzle 460 can be set and / or assisted through engagement of additional features on the housing 402 with the housing interface 480, as would be understood by one of ordinary skill in the art in accordance with the teachings of the present disclosure.

[0074] FIG. 13 is a cross-sectional view of the device 400 cut along plane B in the orientation shown in FIG. 9. Some of the components of the housing 402 have been removed to emphasize the dosing lock 420 and the vial lock 430. Further components of the housing 402 (including the chassis 416) are shown in FIGS. 14B and 15. FIG. 13 is a cross-sectional view of the device 400 cut along plane B in the orientation shown in FIG. 9. Some of the components of the housing 402 have been removed to emphasize the dosing lock 420 and the vial lock 430. Further components of the housing 402 (including the chassis 416) are shown in FIGS. 14B and 15. FIG. 13 is a cross-sectional view of the device 400 cut along plane B in the orientation shown in FIG. 9. Some of the components of the housing 402 have been removed to emphasize the dosing lock 420 and the vial lock 430. Further components of the housing 402 (including the chassis 416) are shown in FIGS. 14B and 15. FIG. 13 is a cross-sectional view of the device 400 cut along plane B in the orientation shown in FIG. 9. Some of the components of the housing 402 have been removed to emphasize the dosing lock 420 and the vial lock 430. Further components of the housing 402 (including the chassis 416) are shown in FIGS. 14B and 15.

[0075] Each of the locks 420, 430 includes a motor 426, 436, a cam 424, 4 34, and a sliding extension 422, 432. When the nozzle 460 is fully extended as shown, the sliding extension 422 of the dosing lock engages the lower notch 496 on the housing interface 48 0, and the sliding extension 432 of the vial lock engages the lower ledge 499 of the vial lock opening 498 of the housing interface 480. When the dosing lock 420 and the vial lock 430 are both locked and the nozzle is in the fully extended position, the dosing lock 420 prevents the nozzle 460 from being pushed down, and the vial lock prevents the extension of the nozzle 460. When the dosing lock 420 is open, the vial lock 430 provides a locking portion that sets the fully depressed position of the nozzle 460. The lower ledge 499 and the bottom of the vial lock opening 498 that fit with the surface of the sliding extension 432 of the vial lock 430 are each angled downward and inward. In this position, the vial lock 430 is prevented from disengaging the housing interface 480 while the dosing lock 420 is engaged with the lower notch 496. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480.

[0076] To remove the nozzle 460 and the vial 500, an authorized user (e.g., a doctor) prevents the nozzle 460 from being pushed down, and the vial lock prevents the extension of the nozzle 460. When the dosing lock 420 is open, the vial lock 430 provides a locking portion that sets the fully depressed position of the nozzle 460.

[0077] The lower ledge 499 and the bottom of the vial lock opening 498 that fit with the surface of the sliding extension 432 of the vial lock 430 are each angled downward and inward. In this position, the vial lock 430 is prevented from disengaging the housing interface 480 while the dosing lock 420 is engaged with the lower notch 496. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. When in this position, the vial lock 430 is prevented from disengaging the housing interface 480 while the dosing lock 420 is engaged with the lower notch 496. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. When in this position, the vial lock 430 is prevented from disengaging the housing interface 480 while the dosing lock 420 is engaged with the lower notch 496. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. When in this position, the vial lock 430 is prevented from disengaging the housing interface 480 while the dosing lock 420 is engaged with the lower notch 496. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. If the user attempts to pull the nozzle 460 out of the housing 402, the sliding extension 432 slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. slides against the lower ledge 499 and further extends into the housing interface 480, thereby enabling further engagement with the housing interface 480. Thereby enabling further engagement with the housing interface 480.

[0078] To remove the nozzle 460 and the vial 500, an authorized user (e.g., a doctor) ​The teacher or pharmacist) sends a command to the dispensing device 400 to remove the vial 500 Trust. The dosing lock 420 disengages, and the authorized user depresses the nozzle 460 to disengage the cut-off of the housing interface 480, and a sensor (e.g., one or multiple optical sensors looking at the openings 490, 492, 494) detects that the nozzle 460 is depressed and the vial lock 430 unlocks, and then the vial 500 can be removed.

[0079] The release of each lock 420, 430 rotates the respective cams 242, 434 and slides the respective sliding extensions 422, 432 outwardly away from the housing interface 480, thereby disengaging the housing interface 480, and can include the rotation of the respective motors 42 6, 436. The closing of each lock 420, 430 rotates the respective cams 242, 434 in the opposite direction of release, releases the respective sliding extensions 422, 432, and springs 428, 438 (see FIG. 14B) push the respective sliding extensions 422, 432 toward the housing interface 480, thereby engaging the housing interface 480, and can include the reverse rotation of the respective motors 426, 436. toward the housing interface 480, thereby engaging the housing interface 480, and can include the reverse rotation of the respective motors 426, 436.

[0080] The dosing lock 420 can include an angled sliding extension 422 shaped to engage the notch 496 at the housing interface 480 of the nozzle 460. The extension 422 of the dosing lock 420 can ratchet over a plurality of notches 496 (see FIG. 11A).

[0081] ​​​​​​​Figures 14A and 14B are top views of the housing 402 orthogonal to the faces A and B, respectively. Figure 14B is a cross-sectional view of the housing 402 cut along the plane C shown in Figure 13. It is.

[0082] Figure 14A shows the upper surface 404a, the opening 412, the chamber cavity 414, the sliding extension 422 of the dosing lock 420, and the sliding extension 432 of the vial lock 430. The vial lock 430 includes upper and lower fins. As shown in Figure 13, the lower fin is shaped to engage the lower ledge 4 99 of the vial lock opening 490 of the housing interface 480 of the nozzle 460. The upper fin is shaped to engage the upper ledge 497 of the vial lock opening 498 so as to set the fully extended position of the nozzle 460. The opening 412 includes a key extension 413. The housing interface 480 is scored on the side shown in Figure 10 to properly orient the nozzle 460 when the housing interface 480 is inserted into the opening 412.

[0083] Figure 14B shows additional component parts of the housing 402 and the locks 420, 430. Each lock 420, 430 is positioned such that its respective cam is shown, and each includes a spring 428, 438 attached to its respective sliding extension 422, 4 32 to move the locks 420, 430 to the closed position. The cams 424, 434 are positioned as mirror images of each other, or alternatively may be positioned in other forms as understood by those skilled in the art in accordance with the teachings of the present disclosure. To release the locks 420, 430, the cam 424 of the dosing lock 420 rotates clockwise, and the vial lock 43 ​ 0 cam 434 rotates counterclockwise (i.e., due to the mirror symmetry of cams 424, 434). As each cam 424, 434 rotates, they 432, respectively. 432 outwardly toward the open position. The bumps 423, 433 are arranged to minimize lateral movement of the extensions 422, 432. 422, 432, respectively. This reduces the risk of the lock jamming compared to an unengaged engagement. and the cams 424, 434 preferably have a small contact area, It is therefore configured to have low friction compared to the larger contact area.

[0084] Another option is to have one or both cams 424, 434 on the bumps 423, 433. This option opens locks 420 and 430. Does not rely on motor gearbox friction to keep it moving, so less effort is required for motor selection Allows for many options.

[0085] Each lock 420, 430 locks its respective cam when it reaches the end of its rotational travel. Vertical extensions 425, 435 of 424, 434 are provided with pressing stops 415, 417 Each stop 415, 417 is preferably fitted with a respective sliding extension 422, 432. The housing 402 is not necessarily mounted on the chassis 416, but is integrated into the chassis 416 (see also FIG. 15). The locking portions 415 and 417 integral with the 6 are locking portions integral with the sliding extensions 422 and 432. In comparison, the respective cams 424, 434 engage with the respective catches 415, 417. When the sliding extensions 422, 432 are in the closed position, the likelihood of rotation (and therefore jamming) of the respective sliding extensions 422, 432 is reduced. The chassis 416 also includes springs 428, 438 and a motor 426, 436. The casing 436 may provide structural support for or engage with the casing 436.

[0086] With continued reference to FIG. 14B, the housing 402 is a printed circuit board having electrical components connected thereto. The device 400 includes a circuit board 440, which together perform various functions of the device 400. The circuit board 440 includes a processor and a non-transitory computer having instructions. The instructions, when executed by a processor, may include a computer-readable medium. Circuitry may be used to perform the functions described herein, including those described in connection with the system shown in FIG. The circuit board 440 need not take the particular form shown. The electrical circuitry of the housing 402 may be, for example, a rigid board, a flexible circuit, or a discrete The electrical circuit may include components, free-running wiring, and / or combinations thereof. As will be understood by those skilled in the art following the teachings of this disclosure, The device 400 can perform the functions described herein as described above. The pathway may be implemented using a drug sensor 138, a tactile switch 140, and / or other suitable devices as described elsewhere herein. The system may further include a real-time clock such as that described in

[0087] The electrical circuit includes three optical sensors 442, 444, 446 mounted on a circuit board 440. Each sensor 442, 444, 446 is connected to a housing interface 48 of a nozzle 460. are positioned to view respective apertures 494, 492, 490 within 0. Each sensor 442, 444, 446 are configured to provide sensor signals indicative of the depressed position of the housing interface At least the central sensor 444 is positioned to provide a sensor signal indicative of a partially depressed position of the nozzle between a fully extended position and a fully depressed position Monitoring the partial depression of the nozzle 460 can be useful for determining drug administration and / or for preventing unauthorized changes In some embodiments, the electrical circuit can be configured to close the dosing lock 420 in response to receiving a sensor signal from a central sensor indicative of a partially depressed position of the nozzle over time and / or repeated partial depressions In some embodiments, the processor receives the sensor signal and executes instructions in memory to activate the motor 426 in the electrical circuit, thereby rotating the cam 424 and closing the lock 420 configured The device 400 can include additional or alternative sensors and / or indicators for detecting partial depression of the nozzle 460. As one example, the housing interface 480 can include a high contrast image instead of a series of openings such as horizontal lines across the outer surface 482 of the housing interface 480. As the nozzle 460 is depressed, the electrical circuit can determine the number of lines passing in front of one or more optical sensors 442, 444, 446 based on signals from the sensors. Additionally or alternatively, the horizontal lines can vary in thickness such that it can be determined which lines are viewed by the optical sensors to be In some embodiments thereby configured

[0088] can be including across can include When the nozzle 460 is depressed, the electrical circuit can determine the number of lines passing in front of one or more optical sensors 442, 444, 446 based on signals from the sensors In addition alternatively, the horizontal lines can vary in thickness such that it can be determined which lines are viewed by the optical sensors Separate sensor signals can be created depending on whether it is present. As another example, the housing interface 480 can include conductive strips, and the circuit board 440 can be electrically contacted simultaneously with the conductive strip when the nozzle 460 is partially depressed, and can include two or more contacts positioned so as to do so. The electrical circuit of the housing 402 can detect when the contacts are short-circuited, thereby detecting the partial depression of the nozzle 460 at one or more

[0089] Using the upper and lower openings 490, 494, it can be determined when the nozzle 460 is in the fully extended position or the fully depressed position. Alternatively, the housing 402 can include limit switches that detect when the nozzle 460 is in the fully extended and / or fully depressed position.

[0090] The engagement of the cams 424, 434 with the locking portions 415, 417 can be detected by monitoring the current to the respective motors 426, 436. When the electrical circuit detects an increase in current that exceeds a predetermined threshold (such as provided by instructions in the memory), the electrical circuit can reduce or remove the power to the motors 426, 436.

[0091] The electrical circuit can further include a sensor (such as an optical sensor) for detecting the vial 500.

[0092] The electrical circuit section can be powered by a battery 448 integrated into the housing 402. can be achieved. The electrical circuit can include a battery charge adjustment and battery protection circuit (e.g., overvoltage , undervoltage, overcurrent, etc.).

[0093] The electrical circuit can be configured to hold the dosing lock 420 for a set dosage amount (e.g., input by a physician or pharmacist), and then return the dosing lock 420 to the closed / locked position. When returning to the closed / locked position, the spring 428 pushes the dosing lock extension 422 to engage with the housing interface 480.

[0094] FIG. 15 shows an exploded view of the components of the device 400 and the vial 500. The nozzle 4 60 includes a handle portion 463, a spring 478, and a retaining ring 476. The vial 500 includes a liquid container 502, an atomizer 504, and a vial nozzle 508. The housing ring 402 includes an upper cover 451, an optical guide 453, and an upper ring 454, which together form the upper surface 404a of the housing 402. The housing 402 further includes an LED substrate 452 including a light-emitting diode (LED) positioned to illuminate the optical guide 453. The same or additional LEDs can provide illumination for a light sensor within the housing 402. The components of the dosing lock 420 and the vial lock 430 are fixed to the chassis 416 by their respective lock covers 427, 437. The circuit board 440 includes a mounted scan nest 456 to which a biosensor 408 can be mounted. The lock covers 427, 437 and the circuit board 44 0 are attached to the chassis by screws 455. Of course, in accordance with the teachings of the present disclosure ​​​​​As would be understood by one of ordinary skill in the art, alternative fasteners, adhesives, snaps, or other strategies can be used to secure the components within the chassis 416 and / or within the housing 402.

[0095] The housing 402 can be charged by inductive charging. The housing 402 includes an inductive coil 450 positioned near the lower end 406 of the device 400 inside the cover 418. The cover 418 can include a co-molded ring 457 near the lower end 406 for additional stability to prevent the device 400 from tipping over during charging. The electronic circuitry of the housing 402 can include a circuit for inductively charging the battery 448 using the coil 450, including circuits designed according to currently available inductive chargers and other such wireless charging methods not yet developed. By incorporating wireless charging into the housing, the need for a charging port is eliminated, thereby eliminating an entry point for the user and thus providing a more robust device against unauthorized modification compared to devices having a wired charging port. Further, since the user has no direct access to the charging mechanism, a device having wireless charging can be made more resistant to damage (at least to the charging circuitry) compared to a device having a wired charging port.

[0096] The entire assembly has no exposed screws, by virtue of the cover 418 that clips onto the chassis 416. Before the cover 418 is clipped on, the functions of the mechanical and electrical components can be assembled and tested on the chassis 416.

[0097] ​​​Figures 16A - 16C are diagrams of an alternative handle portion 463 of the nozzle of the dispensing device 400 shown in FIGS. 11A and 11B. The handle portion 463 includes an upper portion 463a and a lower portion 463b that are manufactured as two separate parts. The upper portion 463a and 463b include clips 465 that can engage with each other in a manner resistant to unauthorized modification so that the upper portion 463a is fixed to the lower portion 463b, which means that the upper portion 463a and the lower portion 463b cannot be easily separated by a recipient of the drug. The handle portion 463 can include a cradle 467 sized to accommodate the push - down tab 510 of the vial nozzle 508 (see FIG. 15). The cradle 467 can be sized to accommodate a larger push - down tab 510 that can be seen on many pharmaceutical vials 500 currently in use in the industry.

[0098] The nozzle 460 of the dispensing device 400 having a handle portion 463 as shown in FIGS. 16A - 16C removes the vial nozzle 508 from the vial 500, places the retaining ring 476 and the spring 478 on the vial 500, slides the housing interface 480 over the spring and the retaining ring 476, places the vial nozzle 508 on the vial 500, positions the push - down tab 510 within the cradle 467 of the lower portion 463b of the handle portion 463, snap - engages the upper portion 463a of the handle portion 463 over the vial nozzle 508, and secures the lower portion 463b of the handle portion 463, whereby it can be fitted to the vial 500. The nozzle 460 is attached to the vial 500. The attachment sequence may be performed in a variety of ways, and the steps may be performed in an order different from those listed, as understood by those skilled in the art of the relevant art. For example, the vial nozzle 408, spring, and / or retaining ring 476 may be fixed within the handle portion 463 before the vial 50 0 is inserted into the handle portion 463. The housing interface 480 may move over the vial 500 and snap engage under a raised portion on the vial to include a flexible hook 481 that extends to engage and secure the nozzle 460 to the vial 500. When the nozzle 460 of the dispensing device is attached to the vial 500, the nozzle 460 may be inserted into the housing 402, and the dispensing device 400 may function as described with respect to FIGS. 9-15. FIGS. 16A-16C show an exemplary geometry of a handle portion 463 having separate portions that can secure the vial nozzle 508 in a form that prevents unauthorized modification. As will be understood by those skilled in the art, other alternative forms may be constructed that include a handle portion 463 that is divided into two perpendicular portions and / or includes three or more separate portions. FIG. 17 shows a developed view of another embodiment of a dispensing device 600 according to the present invention. FIG. 18A shows a cross-sectional view of the dispensing device in plane A as shown in FIG. 17. FIG. 18B shows a cross-sectional view of the dispensing device in plane B as shown in FIG. 17.

[0099] The difference between the dispensing device 600 shown in FIG. 17 and the device 400 shown in FIGS. 9-15 is that as will be understood by those skilled in the art other alternative forms may be constructed that include a handle portion 463 that is divided into two perpendicular portions and / or includes three or more separate portions. may also be constructed.

[0100] FIG. 17 shows a developed view of another embodiment of a dispensing device 600 according to the present invention. FIG. 18A shows a cross-sectional view of the dispensing device in plane A as shown in FIG. 17. FIG. 18B shows a cross-sectional view of the dispensing device in plane B as shown in FIG. 17.

[0101] The difference between the dispensing device 600 shown in FIG. 17 and the device 400 shown in FIGS. 9-15 is ​The vial 500 can be loaded from the bottom of the device 600, and the nozzle is integral with the housing (i.e., it cannot be detached without damage or without special disassembly). The dispensing device 600 shown in FIG. 17 includes partial dosing detection, biological scanning, wireless and / or wired communication to other computing devices, programmability for timed dosing, micro motion detection, drug identification, drug dose sensing, and other electrical circuits and components for performing other functions as described for the other dispensing device embodiments 100, 400 described elsewhere in this specification (e.g., mechanical and / or electrical parts). Referring collectively to FIGS. 17, 18A, and 18B, the dispensing device 600 includes a handle portion 663, an upper cover 651, an LED substrate 652, an optical guide 653, an upper rim 654, a housing interface 680, a spring 678, a chassis 616,

[0102] a battery 648, a biosensor 608, a sliding dosing lock extension 622, a dosing lock cam 624, a dosing lock motor 626, a C-shaped vial lock extension 632, a vial lock cam 634, a vial lock motor 636, a circuit board 640, a cover 618, a finger cover 610, a cover co-molding 657, and a base 658. The upper cover 651, LED substrate 652, optical guide 653, and upper rim 654 are assembled similarly to the corresponding components 451, 452, 453, 454 of the dispensing device 400 shown in FIGS. 9 - 15.

[0103]

[0104] ​​​​​​The nozzle of device 600 includes a handle portion 663, a spring 678, and a housing interface face 680. The handle portion 663 is similar to the conical portion 462 and the engagement ring 466 of the handle portion 463 of the nozzle 460 of the dispensing device 4 00 shown in FIGS. 9 to 15, and includes a similar conical portion and an engagement ring. The handle portion 663 and the housing interface face 680 clip onto each other. The housing interface 680 has an outer surface 682 that includes features for detecting partial depression and

[0105] extrusion of the nozzle, similar to the features on the outer surface 482 of the housing interface 480 of the dispensing device 400 shown in FIGS. 9 to 15. Similarly, the electrical circuit of device 600 (i.e., the circuit board 640 and other electrical components) includes sensors for detecting the position and / or movement of features on the housing interface 680. The device 600 includes limit switches that detect when the nozzle of the device 600 is in a fully extended and / or fully depressed position. Additionally or alternatively, the device 600 can include openings in the housing interface 480 similar to the openings 4 90, 494 of the device 400 shown in FIG. 10 for detecting when the nozzle of the device 600 is in a fully extended and / or fully depressed position. The housing interface 680 further includes serrations 696 positioned to engage the dosing lock extension 622. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed. The device 600 includes limit switches that detect when the nozzle of the device 600 is in a fully extended and / or fully depressed position. Additionally or alternatively, the device 600 can include openings in the housing interface 480 similar to the openings 4

[0106] 90, 494 of the device 400 shown in FIG. 10 for detecting when the nozzle of the device 600 is in a fully extended and / or fully depressed position. The device 600 includes limit switches that detect when the nozzle of the device 600 is in a fully extended and / or fully depressed position. Additionally or alternatively, the device 600 can include openings in the housing interface 480 similar to the openings 4 90, 494 of the device 400 shown in FIG. 10 for detecting when the nozzle of the device 600 is in a fully extended and / or fully depressed position. 90, 494 of the device 400 shown in FIG. 10 for detecting when the nozzle of the device 600 is in a fully extended and / or fully depressed position. The housing interface 680 further includes serrations 696 positioned to engage the dosing lock extension 622. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed. The housing interface 680 further includes serrations 696 positioned to engage the dosing lock extension 622. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed.

[0107] The housing interface 680 further includes serrations 696 positioned to engage the dosing lock extension 622. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed. The housing interface 680 further includes serrations 696 positioned to engage the dosing lock extension 622. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed. The serrations 696 prevent depression of the nozzle and are angled to allow extension when the handle 663 is partially depressed. is enabled. The dosing lock 620 (including the dosing lock extension 622, the cam 624, and the motor 62 6) can perform a ratchet operation over the notch 696 similar to the functions of the dosing lock 420 and the notch 49 6 of the device 400 shown in FIGS. 9-15. The dosing lock extension 622 is provided with an angled ledge 695 that fits within the angled notch 696. The dosing lock extension 622 has a ring shape. The dosing lock is pushed into the locked position by a spring 628. The cam 624 and the motor 626 of the dosing lock are positioned on the opposite side of the ring of the dosing lock extension 622 (compared to the angled ledge 695). To release the dosing lock, the motor 626 operates to turn the cam 624, thereby pushing the dosing lock extension 622 against the force of the spring 628 and moving the angled ledge 695 out of the notch 696.

[0108] The vial lock 630 includes a C-shaped vial lock extension 632, a vial lock cam 634, and a vial lock motor 636. The general orientation of the vial lock 630 is upside down compared to the vial lock 430 of the device 400 shown in FIGS. 9-15 so as to facilitate the removal of the vial 500 through the bottom 606 of the device 600. The base 658 fits onto the chassis 616 and is held in place by the engagement of the vial lock extension 632 with the notch 698 on the base 658. To release the vial lock 630, the motor 636 operates to rotate the cam 634, thereby disengaging the vial lock extension 632 from the notch 698 on the base 658. The vial lock extension The elongate portion 632 is held in the locked position by a spring and the vial lock motor 636 is actuated to rotate the cam 634 such that the vial lock extension 632 is released by pushing against the spring. The base 658 can include a plurality of angled notches for latching movement of the base 658 within the device 600. The ratchet prevents movement of the base 658 out of the device 600 and allows movement of the base 658 into the device 600. The vial lock 630 may alternatively comprise a ring gear lock that circumscribes the vial 500. The alternative design can increase the reliability of the system and / or reduce the manufacturing cost. The motor turns the ring gear lock, thereby disengaging the vial lock while the vial holder / base 658 is in place. When the vial 500 is absent, the ring gear lock returns to the locked position. The base 658 is then pushed back to lock in place. The lock clip relies on the spring action of the plastic clip for the base to move to lock. The positions of the dosing lock 620 and the vial lock 630 are detected by measuring the increase in current when the respective cams 624, 634 are rotated by the respective motors 626, 636 to the locking portion, similar to that described in relation to the device 400 illustrated in FIGS. 9 - 15. The device 600 further includes a sensor (e.g., a limit switch or an optical sensor) for detecting the presence of the vial 500.

[0109]

[0110]

[0111]

[0112] ​​​​​​​​​​​​​​​ The entire assembly can be free of exposed screws by a cover 618 that clips onto the chassis 616. Before the cover 618 is clipped on, the functions of the mechanical and electrical components can be assembled and tested on the chassis 616.

[0113] The device 600 includes a mini USB port for charging. Alternatively, the device 600 can include a coil or inductive charging, and / or an alternative charging port such as a USB C, dedicated charging port, or other charging port understood by those skilled in the art in accordance with the teachings of the present disclosure.

[0114] FIG. 19 shows a system diagram of an exemplary system including a digital platform 700, a user device 800, and a dispensing device 900. The digital platform 700 and the user device 800 can each include a computing device 200 as described herein, an alternative thereto, and / or a variation thereof recognized and understood by those skilled in the art in accordance with the teachings of the present disclosure. The dispensing device 900 can include any one of the dispensing devices 100, 400, 600 described herein, an alternative thereto, and / or a variation thereof recognized and understood by those skilled in the art in accordance with the teachings of the present disclosure.

[0115] An authorized user 702 (e.g., a physician) can receive information regarding medication compliance, nozzle position, vial type, patient information, device information, prescription information, dosage information, and dispensing device unauthorized changes via the digital platform 700. The information is dispensed. It can be provided as the output 904 of the device 900. An authorized user 702 can input commands regarding nozzle lock / unlock, vial lock / unlock, and / or biometric lock / clear via the digital platform 700. The digital platform can communicate with the dispensing device 900 via an application on the user device 800.

[0116] A user (e.g., a patient) can be authenticated by the dispensing device 900 via the user device 800 and / or the biometric scanner 908. The user device 800 can further receive information regarding the dosing schedule, reminders, and medication compliance from the dispensing device 900.

[0117] The dispensing device 900 can include a motor 926 and a cam 924 positioned to engage the nozzle lock mechanism 922. The motor 926, cam 924, and nozzle lock mechanism 922 can have a structure and / or function similar to that of the dispensing devices 100, 400, 600 described herein for locking the nozzle position to prevent dosing, its variations, or alternatives that can be understood by those skilled in the art according to the teachings of the present disclosure.

[0118] The dispensing device 900 can include a motor 936 and a cam 934 positioned to engage the vial lock mechanism 932. The motor 936, cam 934, and vial lock mechanism 932 can have a structure and / or function similar to that of the dispensing devices 100, 400, 600 described herein for fixing the vial within the dispensing That variation, or an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure can be had.

[0119] The dispensing device 900 can accommodate a vial such as vial 500, a variation thereof, or an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure can be had.

[0120] The dispensing device 900 can be provided with a nozzle 960 that can be depressed to dispense a medicament, and on the dispensing device, features for locking and / or dosing detection as described elsewhere herein, a variation thereof, and an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure can be provided. / or an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure can be provided.

[0121] The dispensing device 900 can be provided with an optical sensor 944 for detecting partial depression of the nozzle 960, detecting the presence of the vial 500, detecting entry into the dispensing device 900, and / or other functions of the optical sensor as described elsewhere herein, a variation thereof, and an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure for an alternative thereof. / or an alternative thereof as would be understood by a person skilled in the art according to the teachings of the present disclosure can be provided.

[0122] The dispensing device 900 can be provided with a gesture sensor 901 (e.g., a micro motion sensor) for detecting a user-specific movement pattern to be detected when different users handle the device 900 can be had.

[0123] Although the present invention has been shown and described with reference to specific exemplary embodiments, without departing from the spirit and scope of the present invention and without limiting the present invention as claimed herein and without departing from the scope of the present invention as claimed herein ​​​It is understood by those skilled in the art that various detailed modifications can be made without further ado. Furthermore, when an exemplary embodiment is described with reference to a specific number of elements, it is understood that the exemplary embodiment can be implemented using either fewer or more elements than the specific number of elements.

Description of Reference Numerals

[0124] 100 Dispensing device 102 Housing 104 First closed end 104a Surface 106 Second closed end 106a Base plate 108 Nozzle 110 Recess 112 Display, display screen 114 First part 116 Second part 118 Liquid container 120 Pump, pump assembly 122 Channel 124 Solenoid 126 Printed circuit board 128 Battery 130 Signal LED 132 Lens 134 Biosensor 136 Photocell 138 Drug sensor 140 Tactile switch 142 Real-time clock, real-time clock chip 200 Computing device 242 Cam 300 Motor assembly 302 Motor 304 First gear 306 Opening 308 Internal gear 310 Central lock 312 Key groove ​​314 Shaft 316 Key 318 Aperture 320 Bottom surface 322 Second gear 324 Disk 326 Notch 328 L-shaped flange 330 Top surface 400 Dispensing device 402 Housing 404 First upper end 404a First surface, first top surface 406 Second lower end 406b Second bottom surface 408 Biosensor 410 Finger cover 412 Opening 413 Key extension 414 Chamber, chamber cavity 415 Locking part 416 Chassis 417 Locking part 418 Cover 419 Outlet 420 Medication lock 422 Sliding extension 423 Bump 424 Cam 425 Extension 426 Motor 427 Lock cover 428 Spring 430 Vial lock 432 Sliding extension 433 Bump 434 Cam 435 Extension 436 Motor 437 Lock cover 438 Spring 440 Printed circuit board 442 Optical sensor 444 Optical sensor, central sensor 446 Optical sensor 448 Battery 450 Induction coil 451 Upper cover 452 LED substrate 453 Light guide 454 Upper ring 455 Screw 456 Scan nest 457 Co-molded ring 460 Disposable nozzle, dedicated nozzle 461 Nozzle cap 462 Conical part 463 Handle part 463a Upper part 463b Lower part 464 Fluid passage 465 Clip 466 Engagement ring 467 Cradle 468 Upper surface 470 Bottom surface 472 Distribution end 474 Base end 476 Holding ring 478 Spring 480 Housing interface 481 Flexible hook 482 Outer surface 484 Upper end 486 Lower end 488 Passage 490 Visual feature, vial lock opening 492 Visual feature, opening 494 Visual feature, opening 496 Notch 497 Upper ledge 498 Vial lock opening 499 Lower ledge 500 Nasal sprayer, pharmaceutical vial, nasal spray device 502 Liquid container 504 Sprayer 508 Vial nozzle 510 Push-down tab 600 Dispensing device 606 Bottom 608 Biosensor 610 Finger Cover 616 Chassis 618 Cover 620 Medication Lock 622 Sliding Medication Lock Extension 624 Medication Lock Cam 626 Medication Lock Motor 628 Spring 630 Vial Lock 632 C-shaped Vial Lock Extension 634 Vial Lock Cam 636 Vial Lock Motor 640 Circuit Board 648 Battery 651 Upper Cover 652 LED Board 653 Light Guide 654 Upper Rim 657 Cover Co-molding 658 Base 660 Nozzle 663 Handle Part 678 Spring 680 Housing Interface 682 Outer Surface 695 Angled Ledges 696 Score Marks 698 Score Marks 700 Digital Platform 702 User 800 User Device 900 Dispensing Device 901 Gesture Sensor 904 Output 908 Biometric Scanner 922 Nozzle Lock Mechanism 924 Cam 926 Motor 932 Vial Lock Mechanism 934 Cam 936 Motor 944 Optical Sensor 960 Nozzle

Claims

1. A device, comprising: a housing having a chamber and an opening communicating with the chamber; A nozzle, the nozzle having a passageway therethrough and a housing interface. Equipped with The housing interface is sized to be positioned within the opening. and when the housing interface is slidably engaged with the housing, The nozzle is translatable from a fully extended position to a fully depressed position. The housing interface is configured to slidably engage the housing. R, The housing interface is positioned within the opening, and the housing the passage is positioned to communicate with the chamber when the passage is slidably engaged with the A nozzle, a first lock movable from an open position to a closed position, The housing interface slidably engages the housing, and the first When the lock is in the closed position, the first lock locks the housing of the nozzle. The interface is pushed further into the housing through the opening in the housing. to prevent it from being The housing interface slidably engages the housing, and the first When the lock is in the open position, the housing interface the first lock is pushed further into the housing through the opening in the a first lock that is not blocked by a portion of the nozzle between the fully extended position and the fully depressed position a sensor configured to provide a sensor signal indicative of a position at which the sensor is depressed; responsive to the sensor signal, to move the first lock from the open position to the closed position. An electric circuit configured as A device comprising:

2. When the housing interface is slidably engaged with the housing, The first lock, the sensor and the electrical circuit are connected to the housing and the nozzle. The device of claim 1 , wherein the device is entirely contained by

3. The device of claim 1 , wherein the sensor comprises a light sensor.

4. The housing interface is adapted to be connected to the housing. When moved relative to the sensor while slidably engaged, the sensor The housing has a visual feature that provides a sensor signal indicative of a partially depressed position. The device of claim 1 , comprising on an interface.

5. The one or more sensors including the sensor may each be in the fully extended position and the The sensor signal indicates multiple partially depressed positions between the fully depressed position. The device of claim 1 configured to provide a signal.

6. The housing interface has a first angled notch formed in the housing interface. On the base, The first lock is in the closed position and the housing interface is in the closed position. When the face is slidably engaged with the housing, the first angled notch a first angled extension positioned within the The first angled notch and the first angled extension are In the closed position, the housing interface is slidably engaged with the housing. When the housing interface is depressed further into the housing, The first angled extension presses against the first angled notch to prevent the front end from The first angled extension allows the nozzle to move toward the fully extended position. the first angled notch is shaped to be slidable relative to the first angled notch so as to allow the first angled notch to be slidably moved relative to the first angled notch. Item 2. The device described in item 1.

7. The housing interface has a plurality of angled indentations including the first angled indentation. a housing interface including a plurality of angled notches, each of the plurality of angled notches being The housing has a longitudinal axis and the housing is aligned perpendicular to the longitudinal axis. Aligned with each other, The plurality of angled notches and the first angled extension are In the closed position, the housing interface is slidably engaged with the housing. to allow the nozzle to move toward the fully extended position when The first angled extension is slidable relative to each of the plurality of angled notches. It is shaped like this. The angled extension and each of the plurality of angled notches are configured to be in contact with the first lock. in the closed position, the housing interface slidably engages the housing; The first angled extension is aligned with one of the plurality of angled notches. At one time, the first angle is set to prevent depression of the housing interface.

7. The method of claim 6, wherein a grooved extension is shaped to press into each of said angled notches. device.

8. the housing comprises a chassis; The first lock comprises: A locking mechanism is provided for moving the first lock between the open and closed positions relative to the chassis. a slidably translatable extension; a cam rotatable to slidably translate said extension, said rotation of said cam a cam, the engagement of which is limited by engagement of the cam with the chassis; a motor rotatable to move the cam and in communication with the electrical circuit; The device of claim 1 , comprising:

9. The nozzle and the housing are separable from one another without damaging the device. The device of claim 1 .

10. a second lock movable between an open position and a closed position, The housing interface is positioned within the opening, and the second lock is When in the closed position, the second lock prevents the nozzle from moving beyond the fully extended position. Prevent the spread of The housing interface is positioned within the opening, and the second lock is When in the open position, the nozzle is locked to the fully extended position by the second lock.

10. The method of claim 9, further comprising: a second lock that is not prevented from extending beyond the position. device.

11. The housing interface is positioned within the opening and the second lock is When in the closed position, the housing interface is adapted to prevent damage to the device. The device of claim 10 , wherein the device cannot be easily removed from the housing.

12. The housing interface is slidably engaged with the housing, and the first locomotive When the first lock is in the closed position, the second lock is movable from the closed position to the open position. The device of claim 10 .

13. A base member; a second lock movable from an open position to a closed position, The housing has an opening communicating with the chamber and a nozzle communicating with the chamber. a second opening; The base member is positioned within the opening and sized to cover the opening. And, The base member is positioned within the opening and the second lock is in the closed position. when the base member is secured in place by the second lock, The base member is positioned within the opening and the second lock is in the open position. when the base member is moved to not cover the opening, 、 The device of claim 1 further comprising:

14. A nozzle, a cone extending along a longitudinal axis, the cone including a dispensing end, a base end, and a fluid passage; The fluid passage extends along the longitudinal axis through the distribution end and the base end. The cone part and a mating ring extending from the base end and having an upper surface facing the dispensing end and a mating ring extending from the base end and an engagement ring having a bottom surface facing away from the end; A housing interface, the housing interface being configured to an outer surface surrounding the shaft and attached to the engagement ring and spaced from the bottom surface and away from the dispensing end; an upper end extending in a direction perpendicular to the longitudinal axis of the casing; an open lower end including an outer periphery surrounding the longitudinal axis; a substantially tubular passageway extending through said open bottom end and an opening in said exterior surface. a housing interface; The cone is positioned within the tubular passage of the housing interface. a spring sized to engage the base end of the when the spring is positioned within the tubular passage; a retaining ring sized to engage said spring; When the spring and the retaining ring are positioned within the tubular passage, a ring movable to compress said spring; Movement of the ring through the tubular passage causes the outer surface of the housing interface to a nozzle that is visible through the opening in the nozzle hole.

15. a sprayer sized to be positioned within the retaining ring; When the sprayer is positioned within the retaining ring, the housing interface 15. The method of claim 14, wherein the base is longitudinally translatable to actuate the atomizer. nozzle.

16. 1. A nasal substance dispenser comprising: a housing configured to receive a vial of a substance; a nozzle configured for insertion into a nostril of a patient and for dispensing; an actuator movable between an extended position and a depressed position, Movement of the actuator from the depressed position to the depressed position causes the vial to At least a portion of the material in the actuator exits the dispenser through the nozzle. Ta, Determining a position of the actuator between the extended position and the depressed position A sensor configured as described above. A nasal substance dispenser comprising:

17. The sensor detects when the actuator is positioned in the depressed position.

17. The nasal substance dispenser of claim 16, further configured to determine.

18. The sensor detects whether the actuator is in a position between the extended position and the depressed position.

18. The nose of claim 17, further configured to determine that it is positioned in an intermediate position. substance distributor.

19. and a lock configured to prevent movement of the actuator. A nasal substance dispenser according to any one of claims 16 to 18.

20. The lock is configured to lock the actuator from the extended position to the extended position by the sensor. When it is determined that the actuator has moved to an intermediate position between the depressed position and the 20. The nasal substance dispenser of claim 19, configured to inhibit movement of the actuator.

21. The lock is configured to lock the actuator from the extended position to the extended position by the sensor. When it is determined that the button has moved to an intermediate position between the depressed position and the depressed position, configured to prevent movement of the actuator in a direction toward a locked position; 21. A nasal substance dispenser according to claim 19 or 20.

22. The lock continues until a control signal is received by the distributor from a remote device. The control signal is configured to move the lock to an unlocked position. and the unlocked position is a forward translation between the extended position and the depressed position. The nasal substance composition according to any one of claims 19 to 21, which enables the movement of the actuator. Arrangement.

23. A nasal substance dispenser according to any of claims 16 to 22, wherein the sensor comprises an optical sensor.

24. A nasal substance according to any one of claims 16 to 23, wherein the sensor comprises a limit switch. distributor.

25. The lock engages a notch in the actuator to prevent movement of the actuator. A nasal substance dispenser according to any one of claims 19 to 24, configured to stop

26. 1. A pharmaceutical vial comprising: A liquid container; a nozzle portion including a passage therein communicating with the liquid container, the nozzle portion comprising: The vial is pushed down against the liquid container, thereby causing the liquid container to pass through the path. a nozzle portion adapted to engage the liquid container so as to cause fluid transfer of the contents of the liquid container; 1. A housing interface, comprising: a ratchet-shaped notch on the housing interface; and a high contrast visual feature on said housing interface; a housing interface comprising:

1. A pharmaceutical vial comprising:

27. 1. A nasal substance dispenser comprising: a housing comprising a chamber sized to receive a vial of a substance; a nozzle adapted to be inserted into the patient's nasal cavity and to dispense the substance, The nozzle has a housing interface sized to slide in and out of the chamber. A nozzle comprising: Prevents the housing interface from disengaging from the housing when closed and when opened, the housing interface is removable from the chamber. a first lock configured to be capable of When the housing interface is removed from the chamber, the vial is removable from the chamber, and the housing interface is When engaged with the chamber, the vial is secured to the chamber by the housing interface. a first lock that is prevented from being removed from the lever; and a front end of the nozzle within the chamber to prevent the nozzle from dispensing the substance when closed; The housing interface is prevented from moving and, upon opening, the nozzle dispenses the substance. The housing interface is slidable within the chamber to allow a second lock configured to A nasal substance dispenser comprising:

Images