Agents for improving rnai efficiency in lepidopteran insects, and agents for controlling lepidopteran insects

An RNAi enhancer targeting PTDCP in Lepidoptera insects enhances RNAi efficiency by suppressing the expression of this protein, addressing the low RNAi efficacy in Lepidoptera pests and improving pest control.

JP2025102157APending Publication Date: 2025-07-08NAT AGRI & FOOD RES ORG
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Patent Information

Application Number
JP2023219432
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2023-12-26
Publication Date
2025-07-08

AI Technical Summary

Technical Problem

Lepidoptera pests exhibit low RNA interference (RNAi) efficiency due to rapid degradation of double-stranded RNA by nucleases, particularly the REase enzyme, which has hindered practical application of RNA pesticides.

Method used

Development of an RNAi efficiency enhancer targeting a PIN domain and transmembrane domain-containing protein (PTDCP) in Lepidoptera insects, using double-stranded RNA to suppress the expression of this protein, thereby improving RNAi efficacy.

Benefits of technology

The enhancer significantly enhances RNAi efficiency in Lepidoptera insects by suppressing the expression of PTDCP, leading to improved pest control through more effective gene suppression.

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Abstract

To provide a novel agent for improving RNAi efficiency in lepidopteran insects, a novel agent for controlling lepidopteran insects, a novel method for improving RNAi efficiency in lepidopteran insects, and a novel method for controlling lepidopteran insects.SOLUTION: Provided is an agent for improving RNAi efficiency in a lepidopteran insect having a gene encoding a PIN domain and a transmembrane domain-containing protein (PTDCP), the agent comprising a double-stranded RNA that suppresses the expression of the gene.SELECTED DRAWING: None
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Citation Information

Patent Citations

  • Gene for improving RNAi efficiency of Lepidoptera insects, and application thereof

    CN108251397A