Skin external composition

Abstract

To provide a skin external composition which suppresses a decrease in viscosity with time, caused by high concentrations of nicotinic acid amide and water-soluble polysaccharides.SOLUTION: There is provided a skin external composition which comprises (A) water-soluble polysaccharides, (B) 3 mass% or more of nicotinic acid amide and (C) an amphipathic component.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a skin topical composition containing a water-soluble polysaccharide, nicotinamide, and an amphiphilic component. Related to products. [Background technology]

[0002] Nicotinamide is a vitamin that has been used in the skin care field for a long time. It is an ingredient used to promote circulation, anti-inflammatory, and promote ceramide synthesis, and is also effective in improving beauty. It is also known to have whitening, anti-wrinkle and anti-aging effects.

[0003] For example, Patent Document 1 discloses that riboflavin, pyridoxine hydrochloride, nicotinamide and papain are A skin whitening agent containing one or more active ingredients selected from the group consisting of calcium anthrate and has been proposed.

[0004] On the other hand, water-soluble polysaccharides are incorporated into skin care compositions to provide functions such as thickening and moisturizing. do.

[0005] For example, Patent Document 2 discloses a method for producing a gellan gum, which is a water-soluble polysaccharide, and a 4-methoxysalicylic acid Cosmetics containing a microgel composition prepared by pulverizing a salt-containing gel have been proposed. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2004-217629 [Patent Document 2] Japanese Patent Application Laid-Open No. 2008-230994 Summary of the Invention [Problem to be solved by the invention]

[0007] In order to effectively utilize the various effects of nicotinamide, nicotinamide is used at a high concentration. However, the present inventors have developed a formulation containing a water-soluble polysaccharide and 3 When nicotinic acid amide is present in an amount of 100% by mass or more, the viscosity decreases over time. I found some issues.

[0008] Therefore, in the present invention, even if the water-soluble polysaccharide is used in combination with 3% by mass or more of nicotinamide, The object of the present invention is to provide a composition for external use on the skin in which a decrease in viscosity is suppressed. [Means for solving the problem]

[0009] As a result of extensive investigation, the present inventors have found that (A) a water-soluble polysaccharide, (B) nicotinamide triglyceride, % or more in amount, and (C) an amphiphilic component is contained, thereby improving the stability of the composition for external use on skin over time. The present inventors have found that this method can suppress the inevitable decrease in viscosity, and have thus completed the present invention.

[0010] That is, the present invention provides the following external skin composition. Section 1. (A) a water-soluble polysaccharide, (B) nicotinamide at least 3% by mass, and (C) an amphiphilic component A composition for external use on the skin comprising: Section 2. Item 2. The composition for external use on skin according to Item 1, wherein the content of the component (B) is 3 to 20% by mass. Section 3. The component (C) is a phosphorylcholine-containing polymer, a dicarboxylic acid ester, a carbon number 5 to 10 alkanediols and alkylene oxide derivatives represented by the following chemical formula (I): Item 3. The composition for external use on skin according to Item 1 or 2, which is one or more selected from the group consisting of: Z-{O(AO)a(EO)b-(BO)cH}n (I) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms after removing n hydroxy groups. It is a radical obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively. independently between 0 and 200; a, b, and c cannot all be 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different; When Z is a hydrogen atom, n is 1. Section 4. The component (A) is a gum, a heparinoid, an alginic acid, agar, pectin, pullulan, or the like. 4. The method according to claim 1, wherein the soluble fiber is one or more selected from the group consisting of orchids, mannans, and lactic acid bacteria. The composition for external use on skin described in any one of claims 1 to 4. Section 5. In the above chemical formula (I), Z is a hydrogen atom or an alkylmonoaromatic group having 4 to 24 carbon atoms. Alcohol, Glycerin, Trimethylolpropane, Erythritol, Pentaerythritol Alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sol Bitol, inositol, sucrose, trehalose, maltitol, or 1-carbon A group obtained by removing n hydroxy groups from a hydroxy compound of 30 or less Item 5. The composition for external application to skin according to Item 3 or 4, [Effects of the Invention]

[0011] According to the present invention, a high concentration of nicotinamide is contained in a liquid containing nicotinic acid, and the decrease in viscosity over time is suppressed. It is possible to provide a composition for external use on the skin.

[0012] In the present invention, the suppression of the decrease in viscosity over time is achieved by including nicotinamide. This includes not only reducing the degree of viscosity decrease due to the application of the agent, but also cases where the viscosity increases over time. will be done.

[0013] In the present invention, the decrease in viscosity over time may be caused by, but is not limited to, heat or volatiles. This includes a decrease in viscosity over time due to exposure to visible light or ultraviolet light, etc. DETAILED DESCRIPTION OF THE INVENTION

[0014] In this specification, the unit of content "% by mass" is synonymous with "g / 100g".

[0015] The composition for external use on skin of the present invention comprises (A) a water-soluble polysaccharide, (B) 3% by mass or more of nicotinamide, and and (C) an amphiphilic component.

[0016] [(A) Water-soluble polysaccharide] The water-soluble polysaccharide contained in the topical skin composition as component (A) of the present invention is a naturally occurring substance. or may be a substance obtained by chemical synthesis.

[0017] Examples of water-soluble polysaccharides include gums (gellan gum, xanthan gum, sclerotin, Um gum, locust bean gum, biosaccharide gum, tamarind gum, quince gum Gum arabic, carrageenan, tara gum, guar gum, galactan, gum arabic, Tragacanth gum, curdlan, succinoglucan, etc.); carrageenan; heparin analogues Alginates (alginic acid, sodium alginate, propylene glycol alginate) Examples of suitable sugars include: agar (including agarose); pectin; pullulan; mannan; and the like.

[0018] The component (A) of the present invention may be any one of these compounds alone or a combination of two or more of them. Among them, gums, heparinoids, alginates, agar, Preferably, one or more selected from the group consisting of pectin, pullulan, and mannan. , Gellan Gum, Xanthan Gum, Sclerotium Gum, Gum Arabic, Tamarind Sea gum, biosaccharide gum, carrageenan, heparinoids, alginic acids, agar, More preferably, one or more selected from the group consisting of pectin and pullulan. Langmuir gum, xanthan gum, sclerotium gum, carrageenan, heparinoids, one or more selected from the group consisting of glutinous acids, agar, pectin, and pullulan; More preferred are gellan gum, xanthan gum, heparin-like substances, alginic acids, and agar. and pectin, and gellan One or two selected from the group consisting of gum, xanthan gum, heparinoids, and agar Species or more are particularly preferred.

[0019] Gellan gum is a soluble form of Pseudomonas elodea. a) is produced by aerobic fermentation using glucose as a carbon source, and produces glucose, glucuronic acid, When gellan gum is produced by fermentation, the main chain consists of 1- The acetyl and glyceryl groups are present in the three linked glucoses. The resulting gellan gum is native gellan gum, and from this native gellan gum, Deacylated gellan gum is obtained by removing the acylated groups (acetyl and glyceryl groups). The type of gellan gum used in the present invention is not particularly limited, but native gellan gum is The viscosity average molecular weight of gellan gum is more preferably 10,000 to 5,000,000, and more preferably 1 0 to 1,000,000, more preferably 300,000 to 700,000. The topical skin composition of the present invention may be a commercially available product, and is not particularly limited thereto. For example, KE KELCOGEL CG-LA, KELCOGEL CG-HA, KELCOGEL HM, KELCOGEL A DGA (all manufactured by CP Kelco US) can be used.

[0020] Xanthan gum is produced by fermentation of Xanthomonas bacteria using hydrocarbons as a carbon source. The composition for external use on the skin of the present invention contains sugars such as glucose, mannose, and glucuronic acid. Commercially available products may be used, but are not limited to, for example, KELTROL CG, KELT ROL CG-T, KELTROL CG-SFT, KELTROL T(CPKelc o Co., Ltd.), Nomcoat ZZ (Nisshin Oillio Co., Ltd.), Echogum T (Dainippon Sumitomo Pharma Co., Ltd. Co., Ltd., etc. can be used.

[0021] Sclerotium gum is a capsular β-D-glucan that utilizes glucose as a carbon source. from fungal species grown on media containing sucrose or sucrose and a complex nitrogen source plus inorganic salts. Although not particularly limited, for example, glucan having an estimated degree of polymerization of about 100 is produced by Sc glucan obtained from Lerotium glucanicum and having a degree of polymerization of about 800 The gum is obtained from the strain Sclerotium rolfsii. The topical skin composition of the present invention is slightly different from commercially available Products such as AMIGEL (Alban Mulle) may also be used, but are not particularly limited to these. (manufactured by Company r) can be used.

[0022] Gum arabic is obtained from the sap of the Acacia plant, a legume, and contains galactose. It is an acidic polysaccharide whose constituent sugars are L-arabinose, L-rhamnose and glucuronic acid. The topical skin composition of the present invention may be a commercially available product, and is not limited to, for example, Arabidopsis thaliana. For example, UCALL SS (manufactured by Sanei Pharmaceutical Trading Co., Ltd.) can be used.

[0023] Tamarind seed gum is a xyloglucan whose main chain is glucose and whose side chains are xylose. The topical skin composition of the present invention may be a commercially available product, and is not particularly limited thereto. For example, For example, Glyroid 6C (manufactured by Dainippon Pharmaceutical Co., Ltd.) can be used.

[0024] Biosaccharide gums are known as biosaccharide gums-1, 2, 3, and 4. Both are obtained from sorbitol by fermentation, but there are no particular restrictions on the production method. Lidogam-1 is a sugar chain consisting of L-fucose, D-galactose, and D-galacturonic acid. Biosaccharide Gum-2 is a polysaccharide whose main component is rhamnose. α-L-Rhap(1→3)-β-D-Galp-(1→2)-α-LRhap-(1→4)-β-D-GlepA(1→3)-[α-L-Rhap-(1 →2)-]-α-D-Galp-(1). Biosaccharide gum-3 is a polymer of L-fucose, D -galactose, D-galacturonic acid are linked consecutively, but biosaccharides Biosaccharide Gum-4 is a polysaccharide with a lower degree of polymerization and molecular weight than Gum-1. Deacetylated cellulose, 2-D-glucose, and glucuronic acid repeating units It is a branched polysaccharide. Among them, Biosaccharide Gum-1 is suitable for the topical skin composition of the present invention. The topical skin composition of the present invention may be a commercially available product, and is not particularly limited thereto. For example, FUCOGEL 1.5P, which is a biosaccharide gum-1, 1000 PP; Rhamnosoft HP 1.5P, Biosaccharide Gum-2 ; Biosaccharide Gum-4, Glicofilm 1.5P (both from France) -Solabia) can be used.

[0025] Carrageenan is a natural polymer extracted and purified from red seaweed. The main chain is composed of galactose, and the positions and numbers of the sulfate groups bonded to it vary. Depending on whether or not the hydro structure is present, kappa-type carrageenan, iota-type carrageenan, and lambda-type carrageenan are available. The type of carrageenan used in the present invention is not particularly limited, but preferred The preferred carrageenan is kappa carrageenan. NUVISCO type PJ-JPE (manufactured by CP Kelco), Soagina MV1 01, Soagiina MV201, Soagiina MV320M (MRC Polysack (manufactured by Callide Co., Ltd.) can be used.

[0026] Heparinoids are polysulfated mucopolysaccharides such as polysulfated chondroitin. Each monosaccharide molecule contains an average of 0.5 to 5 sulfate groups, of which 0.6 to 3 sulfate groups. Heparinoids include, for example, heparin and chondroitin. These include polysulfated chondroitins such as sulfate D and chondroitin sulfate E. Heparinoids listed in the Japanese Pharmacopoeia Non-prescription Drug Standards can be suitably used.

[0027] Pectin is a polysaccharide whose constituent sugars are rhamnose and galacturonic acid. Some of the carboxylic acids are esterified with methyl or acetyl groups. The molar content (%) of galacturonic acid is defined as the degree of methyl esterification (DE), and DE is 50%. Pectin with a DE of 50% or less is high methoxyl (HM) pectin, and pectin with a DE of less than 50% is low methoxyl (HM) pectin. The topical skin composition of the present invention contains HM pectin and L Commercially available pectins include, but are not limited to, G pectin, M pectin, and the like. ENU pectin LM-104AS-J, GENU pectin USP-H( (manufactured by CP Kelco) can be used.

[0028] Agar is obtained from the mucilage of red algae such as Agarwort and Gracilaria, and is a material that can be used in agarose and agaropex. The topical skin composition of the present invention contains agarose and agaropectin. There are no particular limitations on the degree of polymerization or molecular weight of the agar, or the content of sulfate groups and pyruvic acid groups in the agar. Any of these may be used, and examples of commercially available products include, but are not limited to, Agar AX- 30, UP-6, UP-37CS, Ultra Agar UX-30, UX-200 (and above, Ina Food Industry Co., Ltd.) can be used.

[0029] Pullulan is a maltotriol-based sugar consisting of three glucose units linked by α-1,4 glycosidic bonds. The skin care product of the present invention is a compound in which the sugars are repeatedly linked in a chain form via α-1,6 glycoside bonds. The composition for use may be a commercially available product, and is not particularly limited, but examples thereof include PU101, cosmetics, etc. Pullulan (manufactured by Hayashibara Co., Ltd.) can be used.

[0030] Alginic acids are made up of two types of uronic acid, mannuronic acid and guluronic acid, linked in a linear chain. alginic acid, salts of alginic acid, and alginates such as propylene glycol alginate The salts include sodium salts and potassium salts, among which sodium salts are the most The topical skin composition of the present invention may be a commercially available product, and is not limited thereto. However, for example, Duck Algin NSPM-R (manufactured by Kikkoman Biochemifa Corporation), Mica Algin IL-2 (manufactured by Kimika Co., Ltd.), Duck Algin NSPH2R, Duckloid FF-50-M (Kikkoman Biochemifa Corporation), sodium alginate HG, Sodium alginate SHG (manufactured by Kouhara, Maikon Co., Ltd.) and the like can be used.

[0031] The total content of component (A) is not particularly limited, and may vary depending on the type of water-soluble polysaccharide and the type of other ingredients. The amount is appropriately set depending on the conditions, but it is possible to significantly achieve the effects of the present invention and to improve the stability of the composition. From this viewpoint, the amount of the composition for external use on skin is preferably 0.005% by mass or more, more preferably 0.005% by mass or more, based on the total amount of the composition for external use on skin. or 0.01 mass % or more, more preferably 0.05 mass % or more, and even more preferably 0 0.1% by mass or more. The total content of component (A) in the total amount of the topical skin composition is 100% by weight, from the viewpoint of improving the feeling of use. Preferably, it is 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less. It is preferably 1.5% by mass or less, more preferably 1.5% by mass or less, and particularly preferably 1.2% by mass or less. The total content of component (A) is preferably 0.005 to 5 parts by mass based on the total amount of the topical skin composition. % by mass, more preferably 0.01 to 3% by mass, even more preferably 0.05 to 2% by mass, and even more preferably More preferably, it is 0.1 to 1.5 mass %.

[0032] The total content of gums in the component (A) is not particularly limited, and may be based on the total amount of the topical skin composition. The content is preferably 0.005 to 5 mass%, more preferably 0.01 to 3 mass%, and even more preferably Preferably 0.01 to 2 mass%, even more preferably 0.05 to 1 mass%, and particularly preferably 0. It is 1 to 0.3 mass %. The content of agar in the component (A) is not particularly limited, and may be, based on the total amount of the composition for external use on skin, Preferably 0.01 to 3 mass%, more preferably 0.05 to 2 mass%, and even more preferably It is 0.1 to 1.5 mass %.

[0033] The content of the heparinoid in the component (A) is not particularly limited, and may be any amount. The amount is preferably 0.005 to 5 mass%, more preferably 0.01 to 3 mass%, and further Preferably, it is 0.05 to 1 mass %, more preferably 0.1 to 0.5 mass %, and particularly preferably The content is preferably 0.1 to 0.3 mass %.

[0034] [(B) Nicotinamide] The nicotinamide contained in the topical skin composition as component (B) of the present invention is nicotinic acid It is an amide compound of (vitamin B3 / niacin) and is a water-soluble vitamin. The acid may be an extract from a natural product or may be synthesized by a known method. Specifically, those listed in the 17th edition of the Japanese Pharmacopoeia can be used. It is known to have melanin production inhibitory effects and whitening effects, as well as skin-promoting effects and skin-improving effects.

[0035] In the topical skin composition of the present invention, the content of component (B) relative to the total amount of the topical skin composition is The content of component (B) is determined appropriately based on the balance with other components. The effects of the present invention are remarkable for the total amount of ingredients, and the effectiveness of whitening, anti-aging, etc. is sufficient. From the viewpoint of imparting this, the content is 3% by mass or more, preferably 4% by mass or more, and more preferably 5% by mass or more. It can also be set to % by mass or more. The content of component (B) in the topical skin composition is determined from the viewpoint of improving the stability of the formulation and the feeling of use. With respect to the total amount, it is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably It is preferably 10% by mass or less, and even more preferably 8% by mass or less. The content of component (B) is preferably 3 to 20% by mass based on the total amount of the topical skin composition. It is more preferably 3 to 15% by mass, even more preferably 3 to 10% by mass, and even more preferably The content is usually 3 to 8 mass %.

[0036] The total content of the component (B) relative to 1 part by mass of the total content of the component (A) in the external skin composition of the present invention is The amount is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.5 to 10,000 parts by mass, more preferably 1 to 8,000 parts by mass, and even more preferably 2 to 5,000 parts by mass, and even more preferably 2 to 1000 parts by mass.

[0037] [(C) Amphiphilic component] The amphiphilic component contained in the topical skin composition of the present invention as component (C) has a structure in one molecule. It contains both hydrophilic and hydrophobic groups (lipophilic groups), and as a result, it can be found in both the aqueous and oily (organic) phases. Refers to all compounds that have affinity.

[0038] Such an amphiphilic component is not particularly limited, but for example, alkylene oxide Derivatives, phosphorylcholine-containing polymers, dicarboxylic acid esters, and alkyl esters with 5 to 10 carbon atoms The component (C) of the present invention may be any of these compounds. These can be used alone or in combination of two or more. From the viewpoint of significantly exhibiting the effects of the present invention, it is preferable to use an alkyl group represented by the following general formula (I): Xylene oxide derivatives, 2-methacryloyloxyethyl phosphorylcholine methacrylate Butyl Ester Copolymer, Decaglyceryl Eicosanedioate / Tetradecanedioate, Cyclohexyl Palmitate Bisethoxydiglycol dicarbonate, diethylhexyl succinate, diethyl succinate one or more selected from the group consisting of alkanediols having 5 to 10 carbon atoms, There are two or more types.

[0039] The alkylene oxide derivative used in the present invention is represented by the following formula (I).

[0040] Z-{O(AO)a(EO)b-(BO)cH}n (I) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms after removing n hydroxy groups. It is a radical obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively. independently between 0 and 200; a, b, and c cannot all be 0; AO and EO may be added randomly or in blocks; When n is 2 or more, each of the multiple a's, b's, and c's may be the same or different; When Z is a hydrogen atom, n is 1.

[0041] In the chemical formula (I), Z is preferably hydrogen from the viewpoint of significantly exhibiting the effects of the present invention. Atoms or alkyl monoalcohols with 4 to 24 carbon atoms, glycerin, trimethylolpropane propane, erythritol, pentaerythritol, alkyl glucoside, diglycerin, Xylitol, dipentaerythritol, sorbitol, inositol, sucrose, Hydroxy compounds with 1 to 30 carbon atoms such as lehalose and maltitol are used to Z is preferably a hydrogen atom or a carbon atom. Alkyl monoalcohols with prime numbers 4 to 24, alkyl glucosides, glycerin, diglycerides erythritol, xylitol, dipentaerythritol, pentaerythritol, By removing n hydroxy groups from trimethylolpropane or sorbitol, and more preferably a hydrogen atom or an alkyl group having 4 to 24 carbon atoms. Monoalcohol, glycerin, diglycerin, alkyl glucoside, pentaerythritol Removal of n hydroxy groups from ethanol, trimethylolpropane or sorbitol and more preferably, an alkylmonoalkenyl group having 4 to 24 carbon atoms. Cole, glycerin, diglycerin, alkyl glucoside, pentaerythritol or is the radical obtained by removing n hydroxy groups from sorbitol, in particular Preferably, alkyl monoalcohols having 4 to 24 carbon atoms, glycerin or diglycerin It is a group obtained by removing n hydroxy groups from an alkyl group.

[0042] In the chemical formula (I), AO is an oxyalkylene group having 3 to 4 carbon atoms, for example, oxypropyl propylene group, oxybutylene group (oxy-n-butylene group, oxyisobutylene group, oxy t-butylene group), oxytrimethylene group, oxytetramethylene group, etc. O is preferably an oxypropylene group, an oxybutylene group, more preferably an oxypro It is a pyrene group. BO is an oxyalkylene group having 4 carbon atoms, for example, an oxybutylene group (oxyn -butylene group, oxyisobutylene group, oxyt-butylene group), oxytetramethylene BO is preferably an oxybutylene group.

[0043] In the chemical formula (I), when Z is an alkyl monoalcohol having 4 to 24 carbon atoms, Among them, alkyl monoalcohols having 4 to 22 carbon atoms are preferred from the viewpoint of achieving a significant brightening effect. Alkyl monoalcohols having 4 to 16 carbon atoms are preferred, and alkyl monoalcohols having 4 to 10 carbon atoms are even more preferred. Alkyl monoalcohols are even more preferred.

[0044] In the alkylene oxide derivative used in the present invention, a, b, and c are each independently a, b, and c are each independently preferably 1 to 200. More preferably, it is 2 to 150, even more preferably, it is 2 to 100, and even more preferably, it is More preferably, it is 2 to 70.

[0045] In the chemical formula (I), the total number of AO, EO, and BO monomer units (a+b+ c) ×n is preferably 3 or more, more preferably 3 or more, from the viewpoint of significantly exhibiting the effects of the present invention. It is 5 or more, more preferably 10 or more, and (a+b+c)×n is the number of times that the effect of the present invention is achieved. From the viewpoint of achieving a significant effect, it is preferably 450 or less, more preferably 350 or less, and even more preferably It is preferably 300 or less, and even more preferably 250 or less.

[0046] The molecular weight of the alkylene oxide derivative used in the present invention is such that the effect of the present invention is remarkably exhibited. From this viewpoint, it is preferably 200 or more, more preferably 300 or more, and further Preferably, it is 400 or more.

[0047] The properties of the alkylene oxide derivative are not particularly limited as long as the effects of the present invention are achieved. In the formula (I), from the viewpoint of significantly exhibiting the effects of the present invention, it is preferable to The component is preferably in a semi-solid (including a paste-like form) to liquid form.

[0048] In addition, such alkylene oxide derivatives include polyoxyalkylene glyceryl ethers. ester, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether Polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyethylene Polyoxypropylene oxybutylene alkyl ether, polyoxyalkylene sorbit , polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol Tall ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene Polymethylolpropane, Polyoxypropylene glycol, Polyoxyethylene polyoxy Propylene glycol, polyoxyalkylene xylitol, polyoxyalkylene di Pentaerythritol, Polyoxyalkylene Inositol, Polyoxyalkylene Sulfate tetrose ether, polyoxyalkylene trehalose ether, polyoxyalkylene ethyl ether, etc. Among them, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutyl Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene Polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene poly Oxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polio Polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxy Diethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitan, Polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene sorbitol, Polyoxypropylene erythritol ether, polyoxyethylene erythritol ether ether, polyoxyethylene pentaerythritol ether, polyoxyethylene polyoxy Propylene erythritol ether, polyoxypropylene pentaerythritol ether ether, polyoxybutylene polyoxyethylene pentaerythritol ether, polyoxyethylene pentaerythritol ether Diethylene polyoxypropylene pentaerythritol ether, polyoxyethylene di Glyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene Polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyethylene Polyoxypropylene diglyceryl ether, polyoxyethylene trimethylolpropane , polyoxypropylene trimethylolpropane, polyoxyethylene polyoxypropylene Trimethylolpropane, Polyoxypropylene glycol, Polyoxyethylene polyethylene Polyoxypropylene glycol, polyoxybutylene polyoxyethylene polyoxypropylene Pyrene glycol, polyoxyethylene xylitol, polyoxypropylene xylitol Polyoxyethylene polyoxypropylene xylitol, polyoxyethylene polyol Polyoxypropylene dipentaerythritol, polyoxyethylene dipentaerythritol, Polyoxypropyl-pentaerythritol, Polyoxyethylene Inositol, Polio Polyoxypropylene inositol, polyoxyethylene polyoxypropylene inositol, Polyoxyethylene sucrose ether, polyoxypropylene sucrose ether, poly Polyoxyethylene polyoxypropylene sucrose ether, polyoxyethylene trehalose tetritol ether, polyoxypropylene trehalose ether, polyoxyethylene polyethylene Oxypropylene trehalose ether, polyoxyethylene maltitol ether, poly Polyoxypropylene maltitol ether, and polyoxyethylene polyoxypropylene and one or more selected from the group consisting of maltitol ethers, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Ethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside Coside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbitol, polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene sorbitol, polyoxyethylene polyoxypropylene pentaerythritol ether , polyoxypropylene pentaerythritol ether, polyoxyethylene pentaerythritol Thuritol ether, polyoxybutylene polyoxyethylene pentaerythritol ether ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutyl Polyethylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene Polyoxypropylene trimethylolpropane, polyoxypropylene glycol, Polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxy one or more selected from the group consisting of diethylene polyoxypropylene glycol is more preferred, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxy Propylene alkyl ether, polyoxypropylene alkyl ether, polyoxyb Polyethylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene Polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside Polyoxyethylene polyoxypropylene sorbitan, polyoxyethylene Polyoxypropylene pentaerythritol ether, polyoxybutylene polyoxy Ethylene pentaerythritol ether, polyoxyethylene diglyceryl ether, poly Polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene di Glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceride Glyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxypropylene propylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycols, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Ethylene polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside Glucoside, Polyoxyethylene Diglyceryl Ether, Polyoxypropylene Diglyceride Polyoxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether butylene polyoxyethylene polyoxypropylene diglyceryl ether It is even more preferable to use one or more selected from the above.

[0049] Such alkylene oxide derivatives are commercially available products, but are not particularly limited to, for example: , Unilube 50MB-26 (Polyoxyethylene Polyoxypropylene Butyl Ether (17E.O.)(17P.O.)), Unilube 50MB-168 (Polyoxyethylene Polyoxypropylene butyl ether (37E.O.) (38P.O.)), Unilever 50MB-11 (Polyoxyethylene Polyoxypropylene Butyl Ether (9E.O .)(10P.O.)), Unisafe 10P-8 (Polyoxyethylene Polyoxypropyl ethyl ether (10E.O.) (8P.O.)), Unilube MT-630B (Polyester Polyoxyethylene polyoxypropylene decyl tetradecyl ether (30E.O.) 6P.O.), Unilube MS-70K (Polyoxypropylene stearyl ether ( 15P.O.)) Uniol HS-1600D (Polyoxyalkylene sorbitan), Ronon #208 (Polyoxyethylene Polyoxypropylene Glycol (150E.O. )(35P.O.)), Pronon #124P (Polyoxyethylene (20) Polyoxyprop propylene (20) glycol), Uniol D-2000 (polypropylene glycol) , Macbiobride MG-10E (Polyoxyethylene methyl glucoside (10E.O. )), Macbiobride MG-20E (Polyoxyethylene methyl glucoside (20E. O.), Macbiobride MG-10P (Polyoxypropylene methyl glucoside (1 0P.O.), Macbiobride MG-20P (Polyoxypropylene methyl glucoside (20P.O.)), Wilbride MG2070 (Polyoxybutylene Polyoxyethylene Polyoxypropylene methyl glucosides), Unilube 5TP-300KB (polio Oxyethylene polyoxypropylene pentaerythritol ether (5E.O.) (65 PO); Unilube 50TG-32 (Polyoxyethylene Polyoxypropylene Glycol Glyceryl ether (24E.O.) (24P.O.)), Wilbride S-753 (Poly Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B. O.) (8E.O.) (5P.O.)), Uniox G-1200 (Polyoxyethylene Glycerin), Unilube DGP-700 (Polyoxypropylene diglyceryl ether Unilube DGP-950 (Polyoxypropylene diglyceryl ether) , manufactured by NOF Corporation); SY-DP14 (polyoxypropylene diglyceryl ether), SY-DP9 (Polyoxypropylene diglyceryl ether) (Sakamoto Pharmaceutical Co., Ltd.) Company); Newpol GP-1000 (PPG-16 glyceryl ether), Newpol Polyoxyalkylene sorbitol ether, Newpol PE- 68 (Polyoxyethylene Polyoxypropylene Glycol (160E.O.) (30P .O.)), Newpol PE-78 (Polyoxyethylene Polyoxypropylene Glycopolymer (150E.O.) (35P.O.)), Newpol GEP-2800 (Polyoxygen Ethylene Polyoxypropylene Glyceryl Ether (24E.O.) (24P.O.) ) (all manufactured by Sanyo Chemical Industry Co., Ltd.); Emulgen PP-290 (polyoxyethylene polyoxyethylene) Propylene glycol (160E.O.) (30P.O.), manufactured by Kao Corporation; N IKKOL SG-G2424 (Polyoxyethylene Polyoxypropylene Glyceryl Ester Ether (24E.O.) (24P.O.), NIKKOL SG-DTD630 (Polio Polyoxyethylene polyoxypropylene decyl tetradecyl ether (30E.O.) (6P .O.)) (all manufactured by Nikko Chemicals); GLUCAM P-10 (polyoxypropylene) methyl glucoside (10P.O.)), GLUCAM P-20 (polyoxypropylene It is sold under the names of methyl glucoside (20 P.O.) (both manufactured by Lubrizol Corporation) and others. It is being done. As commercially available alkylene oxide derivatives, from the viewpoint of remarkably exhibiting the effects of the present invention, Unilube 50MB-26, Unilube 50MB-168, Uniol HS-1600D , Pronon #208, Pronon #124P, Uniol D-2000, McBio Bride MG-10E, McBio Bride MG-20E, McBio Bride MG-10P, McBio Obride MG-20P, Wilbride MG2070, Unilube 5TP-300KB , Unilube 50TG-32, Wilbride S-753, Uniox G-1200, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9 , Nieuport GP-1000, Nieuport SP-750, Nieuport PE-68, Nieupol PE-78, Nieupol GEP-2800, NIKKOL SG-G24 24, and Emulgen PP-290. is preferred, Wilbride S-753, Unior HS-1600D, Pronon #208, Pronon #124P, Unior D-2000, McBio Bride MG-10E, McBio Bride Ido MG-20E, McBio Bride MG-10P, McBio Bride MG-20P, Filbride MG2070, Uniox G-1200, Unilube 50TG-32, Nilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, Nieuport GP-1000, Nieuport SP-750, Nieuport PE-68, Nieuport PE-78, Nieuport GEP-2800, NIKKOL SG-G242 4, and Emulgen PP-290. More preferably, Wilbride S-753, McBioBride MG-20P, and McBioBride M G-10P, Unilube DGP-700, Unilube DGP-950, SY-DP14, SY-DP9, and more preferably one or more selected from the group consisting of Wilbride S-753, Unilube DGP-700, Unilube DGP-950, One or more selected from the group consisting of SY-DP14 and SY-DP9 is even more preferred.

[0050] In the present invention, the alkylene oxide derivatives may be used alone or in combination of two or more. Any combination of the above may be used.

[0051] Phosphorylcholine-containing polymers are made by using organic compounds containing phosphorylcholine as monomers. Although not particularly limited, it refers to polymers in general that exhibit the effects of the present invention remarkably. Among them, a monomer containing 2-methacryloyloxyethyl phosphorylcholine is polymerized. A polymer containing methacryloyloxyphosphorylcholine, which is a polymer obtained by Among them, 2-methacryloyloxyethyl phosphorylcholine·butyl methacrylate Copolymer (Polyquaternium-51) and polymethacryloyloxyethyl phosphoryl Preferably, one or more selected from the group consisting of choline, 2-methacryloyloxy Ethylphosphorylcholine-butyl methacrylate copolymer is more preferred. Commercially available polymers containing hydroxybenzoates include Lipidure-PMB (2-methacryloyloxybenzoate). Diethylphosphorylcholine-butyl methacrylate copolymer solution, Polyquaternium-51 , and Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) ( Preferably, one or more selected from the group consisting of (all manufactured by NOF Corporation), dure-PMB (2-methacryloyloxyethyl phosphorylcholine methacrylate bromide) Chilled copolymer liquid) is more preferred.

[0052] Dicarboxylic acid esters are compounds that combine dicarboxylic acids with glycols, glycol ethers, etc. It is a compound condensed with a hydroxy group, and is not particularly limited, for example, (eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10, Cyclohexanedicarboxylic acid bisethoxy Diglycol, 1,4-cyclohexanedicarboxylic acid bis(triethylene glycol mono) ethyl ether), adipate bis(diethylene glycol monoethyl ether), adipate Bis(triethylene glycol monoethyl ether) succinate and diethoxyethylene succinate diethylhexyl succinate, among which (eicosanedioic acid / tetradecanediol) Acid) Polyglyceryl-10, Cyclohexanedicarboxylic acid bisethoxydiglycol, One or more selected from the group consisting of diethoxyethyl succinate and diethylhexyl succinate Preferably, two or more of diethoxyethyl succinate, eicosanedioic acid / tetradecanedioic acid ) Polyglyceryl-10 and bisethoxydiglycol cyclohexanedicarboxylate More preferred are one or more selected from the group consisting of diethoxyethyl succinate, Bisethoxydiglycol cyclohexanedicarboxylate is more preferred. Commercially available products include, but are not limited to, diethoxyethyl succinate (CRODA MOL DES), diethylhexyl succinate (CRODAMOL OSU) (both Croda Japan Co., Ltd.), Neosolue-Aqua, Neosolue-Aqu aS ((eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10), Neosolu e-Aqulio (bisethoxydiglycol cyclohexanedicarboxylate) (manufactured by Nippon Fine Chemical Co., Ltd.) can be used.

[0053] In order to achieve the effects of the present invention more remarkably, the alkanediol preferably has 5 carbon atoms. The ratio is preferably from 1 to 10, more preferably from 5 to 8, and even more preferably from 5 to 6. For example, 1,2-penta from the group consisting of 1,2-hexanediol, 1,2-hexanediol, and 1,2-octanediol One or more selected from the above are preferred, and 1,2-pentanediol and 1,2-hexanediol are preferred. More preferably, one or more selected from the group consisting of diols, and 1,2-pentanediols Furthermore, commercially available products include, but are not limited to, HYDROLIT E-5, HYDROLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (large (Osaka Organic Chemical Industry Co., Ltd.), Microcare Emollient PTGJ, Microcare Em Coliient HXD (manufactured by THOR) and other products can be used.

[0054] In the present invention, the component (C) may include, in addition to the alkylene oxide derivatives described above, 2- Methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer, polymeth Acryloyloxyethyl phosphorylcholine, (eicosanedioic acid / tetradecanedioic acid) poly Glyceryl-10, bisethoxydiglycol cyclohexanedicarboxylate, di-succinate Ethylhexyl, diethoxyethyl succinate, and alkanediols with 5 to 10 carbon atoms Preferably, one or more selected from the group consisting of the alkylene oxide derivatives Also available: 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer , Polymethacryloyloxyethyl phosphorylcholine, (eicosanedioic acid / tetradecane Diacid) Polyglyceryl-10, Cyclohexanedicarboxylic acid bisethoxydiglycol, Diethoxyethyl succinate, diethylhexyl succinate, 1,2-pentanediol, 1 1,2-hexanediol, and 1,2-octanediol It is more preferable to use two or more of the alkylene oxide derivatives, and in addition to the alkylene oxide derivatives, 2-methacryloyl Peroxyethyl phosphorylcholine-butyl methacrylate copolymer, polymethacryloyl octanoate Diethylphosphorylcholine, (eicosanedioic acid / tetradecanedioic acid) polyglyceryl- 10. Cyclohexanedicarboxylic acid bisethoxydiglycol, succinic acid diethoxyethyl 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol More preferably, the alkyleneoxy group is one or more selected from the group consisting of alkyleneoxy groups. In addition to the derivatives, 2-methacryloyloxyethyl phosphorylcholine / butyric acid methacrylate copolymer, bisethoxydiglycol cyclohexanedicarboxylate, diethoxy succinate 1,2-pentanediol, and 1,2-hexanediol. It is even more preferable to use one or more of the above-mentioned components (C). Alternatively, two or more of them may be used in any combination.

[0055] The topical skin composition of the present invention contains component (C) in addition to components (A) and (B). Therefore, under the influence of heat, visible light, ultraviolet light, etc., the viscosity of the water-soluble polysaccharides and nicotinamide is increased. Therefore, the composition for external use on the skin of the present invention is suitable for use under these influences. do.

[0056] When used under the influence of ultraviolet light, the component (C) is not particularly limited, but preferably Alkylene oxide derivatives, phosphorylcholine-containing polymers or alkylenes having 5 to 10 carbon atoms It is benzol.

[0057] The total content of the (C) component is not particularly limited, and may vary depending on the type of water-soluble polysaccharide and the type of other components. The thickness is appropriately set depending on the above factors, but it is important to take into consideration the fact that it significantly exhibits the effects of the present invention and provides a good feeling when used. Therefore, it is preferably 0.001% by mass or more, more preferably 0.001% by mass or more, based on the total amount of the composition for external use on skin. is 0.005% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0. It is preferably 0.05% by mass or more, and particularly preferably 0.1% by mass or more. The total content of component (C) is determined based on the total amount of the topical skin composition from the viewpoint of improving the stability of the preparation. Preferably, it is 20% by mass or less, more preferably 15% by mass or less, and even more preferably 12% by mass or less, even more preferably 10% by mass or less, even more preferably 8% by mass or less Below. The total content of the component (C) is preferably 0.001 to 2% by weight based on the total amount of the topical skin composition. 0 mass%, more preferably 0.005 to 15 mass%, and even more preferably 0.01 to 12 mass% %, even more preferably 0.05 to 10 mass %, and particularly preferably 0.1 to 8 mass %. .

[0058] The total content of the component (C) relative to 1 part by mass of the total content of the component (B) in the external skin composition of the present invention is The amount is not particularly limited, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 0.0 0.001 to 10 parts by mass, more preferably 0.001 to 5 parts by mass, and even more preferably 0.01 to It is 3 parts by mass.

[0059] In the composition for external use on skin of the present invention, the content of the alkylene oxide derivative is determined based on the effectiveness of the present invention. There are no particular limitations as long as the effect is achieved, and the amount is preferably 0.01 to the total amount of the external skin composition. The content is preferably 0.1 to 15% by mass, more preferably 0.1 to 10% by mass, and even more preferably It is 0.5 to 8 mass %.

[0060] In the composition for external use on skin of the present invention, bisethoxydiglycocoyl cyclohexanedicarboxylate The content of ethanol and diethoxyethyl succinate is not particularly limited as long as the effects of the present invention are achieved. The amount of the external skin composition is preferably 0.001 to 10% by mass, more preferably 0.001 to 10% by mass, based on the total amount of the external skin composition. Preferably, the content is 0.005 to 8 mass%, more preferably 0.01 to 5 mass%, and even more preferably Preferably, it is 0.05% by mass to 3% by mass.

[0061] In the composition for external use on skin of the present invention, the amount of 2-methacryloyloxyethyl ether relative to the total amount of the composition is The content of the diphosphorylcholine-butyl methacrylate copolymer is as long as the effect of the present invention is exhibited. It is not particularly limited, and is preferably 0.0001 to 10 mass % based on the total amount of the composition for external use on skin. % by mass, more preferably 0.001 to 7% by mass, and even more preferably 0.005 to 5% by mass %, and even more preferably 0.01% by mass to 3% by mass.

[0062] In the composition for external use on skin of the present invention, the content of the alkanediol having 5 to 10 carbon atoms alone is is not particularly limited as long as the effects of the present invention are exhibited, and is preferably Preferably, the content is 0.0001 to 10% by mass, more preferably 0.001 to 7% by mass, and even more preferably Preferably, it is 0.01 to 5% by mass, and even more preferably, it is 0.1 to 3% by mass.

[0063] [Other ingredients] The composition for external use on skin of the present invention may have other useful effects in addition to the above-mentioned components (A) to (C). In addition, it has UV scattering, UV absorbing, and DNA damage prevention and / or repair properties. Whitening ingredients, anti-inflammatory ingredients, antibacterial ingredients, antiseptic ingredients, refreshing agents, organic acids, anti-glycation ingredients , cell activating ingredients, astringent ingredients, antioxidant ingredients, anti-aging ingredients, moisturizing ingredients, polyhydric alcohol, Skin softening ingredients, vitamins, blood circulation promoting ingredients, sebum absorbing ingredients, peptides or their derivatives, Various components such as amino acids or derivatives thereof may be blended singly or in combination of two or more. These components can be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc. There are no particular limitations on the material, and any material can be appropriately selected and used. Ingredients that fall under multiple categories can be added as ingredients with any of the above effects. Let's say.

[0064] Examples of the ultraviolet scattering agent include zinc oxide, titanium oxide, iron oxide, cerium oxide, Zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silica Inorganic compounds such as acid, and those inorganic compounds such as hydrous silica, aluminum hydroxide, mica, It is coated with inorganic powder such as talc, or made of polyamide, polyethylene, polyester, polystyrene, etc. Compounds of resin powder such as polyethylene and nylon, as well as silicone oil and fatty acid aluminum Examples include those treated with salt, etc. Among them, inorganic oxides such as zinc oxide, titanium oxide, and iron oxide are These inorganic compounds are mixed with inorganic compounds such as aluminum hydroxide, hydrous silica, mica, and talc. It is preferable to use a material coated with inorganic powder or silicone oil. The content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 35% by mass, preferably about 0.1 to 25% by mass, based on the total amount of be.

[0065] Examples of ultraviolet absorbers include 2-ethylhexyl salicylate and homomethyl salicylate. salicylic acid-based ultraviolet absorbers such as ethylene glycol salicylate; Glyceryl p-methoxycinnamate, mono-2-ethylhexanoate; 2-ethyl p-methoxycinnamate Cinnamic acid-based UV absorbers such as hexyl; 4-tert-butyl-4'-methoxydibenzo benzoylmethane-based ultraviolet absorbers such as 2-[4-(diethylamino)-2- Benzoic acid ester derivatives such as hydroxybenzoylbenzoic acid hexyl ester, UV absorbers Collector;Dimethoxybenzylidenedioxoimidazolidinepropionic acid 2-ethylhexyl ester 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1 ,3,3-tetramethylbutyl)phenol];2,4-bis-[{4-(2-ethylhexyl)phenol]; xyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1, 3,5-triazine, diethylhexylbutamidotriazone, 2,4,6-tris[4- (2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, etc. Azine derivatives; benzalmalonate derivatives such as dimethicone diethyl benzalmalonate UV X-ray absorber; 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester Octocrylene UV absorbers such as ter; 2-phenylbenzimidazole-5-sulfone acid, imidazole sulfonates such as disodium phenyldibenzimidazole tetrasulfonate benzophenone derivative ultraviolet absorber; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy Dihydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, dihydroxydimethoxy Dibenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone and the like.

[0066] In the present invention, such ultraviolet absorbers include, but are not limited to, paramethoxyphenyl ether 2-Ethylhexyl cinnamate, 4-tert-butyl-4'-methoxydibenzoylmethacrylate 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester Dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-ethylhexyl ester , 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1 ,3,3-tetramethylbutyl)phenol], 2,4-bis-[{4-(2-ethylhexyl)phenol] xyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1, 3,5-Triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl )Anilino]-1,3,5-triazine, dimethicone diethyl benzalmalonate, 2- Ano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester, and 2-furan one or more selected from the group consisting of phenylbenzimidazole-5-sulfonic acid preferable.

[0067] The ultraviolet absorber may be a commercially available product or may be synthesized.

[0068] Commercially available products include, but are not limited to, Parsol EHS (DSM Nutrition Japan), ESCALOL 587 (Ashland Japan) , EusolexOS (Merck), Parsol HMS (DSM Nutrition (manufactured by BASF), Uvinul MC80 (manufactured by BASF), Parsol MCX (DSM Nutrition Japan), Parsol 1789 (DSM Nutrition (manufactured by Shonen Japan), Uvinal A Plus Granular, Soft Shade D H, Tinosorb M (manufactured by BASF), Milestab 360, Mixxim BB / 100, Tinosorb S (BASF), Uvasorb HEB, Vinal T150 (manufactured by BASF), Heliosun OTZ (O'Laughli n Industries), Parsol SLX (DSM Nutrition Japan), Parsol 340 (DSM Nutrition Japan), Esca Roll 597 (Ashland Japan), Parsol HS (DSM Nutrition) (manufactured by Johnson & Johnson Japan), Eusolex232 (manufactured by Merk), NeoHeliopan AP (made by Harman & Reimer), Juvenal M40, Escarole 567 Ashland Japan), Uvinal MS40 (BASF), SEESORB107 (Cipro Kasei Co., Ltd.), SEESORB100 (Shipro Kasei Co., Ltd.), SEESORB106 (Shipro (manufactured by Kasei Co., Ltd.)

[0069] In the composition for external use on skin of the present invention, the total content of the ultraviolet absorber is , preferably 1 mass % or more, more preferably 3 mass % or more, and even more preferably 6 mass % or more % or more, and even more preferably 7% by mass or more. Preferably, the content is 20% by mass or less, more preferably 15% by mass or less, based on the total amount of the composition. The total content of the ultraviolet absorber is preferably 10% by mass or less. The content is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, and even more preferably Preferably, it is 5 to 10 mass %, and even more preferably, it is 7 to 10 mass %.

[0070] In the topical skin composition of the present invention, the ratio of the total content of the ultraviolet absorber to the component (B) is not particularly limited, but the amount of the ultraviolet absorber is preferably 0 to 1 part by mass of the component (B). 0.1 to 6 parts by mass, more preferably 0.5 to 4 parts by mass, and even more preferably 1 to 2 parts by mass. be.

[0071] In addition, these UV scattering agents and UV absorbers can be compounded, supported, or encapsulated with other components. The combination of these is not particularly limited.

[0072] Examples of components having an effect of preventing and / or repairing DNA damage include those derived from animals (e.g. , Artemia); components derived from plants (e.g., cat's claw); DN A, DNA salts, RNA, RNA salts, and other nucleic acid components. Prevention of DNA damage and / or The content of the ingredient having the repairing effect can be appropriately selected taking into consideration the feel and effect on the skin. However, the amount is, for example, about 0.001 to 3% by mass, preferably about 0.001 to 3% by mass, based on the total amount of the external skin composition of the present invention. When animal or plant ingredients are used, the content is usually about 0.01 to 1% by mass. In terms of extracts such as cucumber, the amount is preferably about 0.0% based on the total amount of the topical skin composition of the present invention. The content is 0.0001 to 0.1% by mass, and more preferably about 0.0001 to 0.01% by mass.

[0073] Whitening ingredients include, for example, placenta, arbutin, kojic acid, ellagic acid, and phytin. Acid; Tranexamic acid; Rucinol; Chamomilla ET; Hydroquinone, 4-Methoxysalicylic Acid potassium salt of linoleic acid; linoleic acid and its derivatives; ascorbic acid and its salts; ascorbic acid Vitamin C derivatives (sodium ascorbyl phosphate, sodium ascorbate) Phosphate ester magnesium, tetra-2-hexyldecanoic acid ascorbyl, 2-O-ethyl Ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glucoside, isostearyl Disodium allyl ascorbyl phosphate, L-ascorbyl dipalmitate, palmitic acid Trisodium Ascorbyl Phosphate, Glyceryl Ascorbate, Bisglyceryl Ascorbate Ascorbic acid, disodium ascorbyl sulfate, hexyl 3-glyceryl ascorbate Ascorbic Acid, 3-Glyceryl Ascorbate, Myristyl 3-Glyceryl Ascorbate, 3-Laurylglyceryl Ascorbate, Potassium Ascorbyl Tocopheryl Phosphate Vitamin A or its derivatives, bread Vitamins such as glutathione and its derivatives are also included. Plant ingredients may be used as whitening ingredients, and examples of such plant ingredients include iris (iris), araliaceae, and argillaceae. Mondo, aloe, acerola, oolong tea, star anise, Scutellaria root, Coptis chinensis, St. John's wort , dead nettle, seaweed, pueraria lobata, gardenia, kudzu, chlorella, rice, rice hyacinth, Lizanol, rice bran, Chinese radish, Japanese pepper, perilla, peony, cnidium, and safflower Kuhi, soybean, natto, tea, angelica, calendula, hamamelis, safflower, peony, Job's tears, Asarum, kiwi, black beans, gentian, Gentian, sage, radish , azalea, parsley, holly, hops, thyme, clove, tangerine, licorice, chamomile , prune, meadowsweet, bark bean, grass jasmine, grapefruit, thorn pear, Lemon, kiwi, pine, neem, artichoke, horsetail, bark, evening primrose , bilberry, geranium, glasswort, white willow, saxifrage, centella These include ingredients derived from plants such as rosemary, lavender, and Chinese quince. When the plant component is used in the skin external composition of the present invention, the form of the plant component is not particularly limited. Usually, it can be used in the form of a plant extract or essential oil. The names in parentheses in the ingredients are the scientific name, alternative name or herbal medicine name of the plant.

[0074] In the present invention, such whitening ingredients include, but are not limited to, placenta; Arbutin; Kojic Acid; Ellagic Acid; Phytic Acid; Tranexamic Acid; Rucinol; Chamomilla ET; Hydroquinone; 4-Methoxysalicylic acid potassium salt; Linoleic acid and its derivatives Ascorbic acid, sodium ascorbate, sodium ascorbyl phosphate Ascorbic acid phosphate magnesium, ascorbic acid tetra 2-hexyldecanoate Ascorbic Acid, 2-O-Ethyl Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Ascorbic Acid Glucoside; Vitamin A oil; Iris, almond, aloe, acerola, chervil, scutellaria Coptis japonica, St. John's wort, dead nettle, seaweed, Pueraria lobata, chlorella, rice, rice bran Burrs, oryzanol, rice bran, perilla, peony, mulberry bark, soybean, tea, and toukin Sensational herb, Hamamelis, Peony, Job's tears, Kiwi, Sage, Parsley, Holly, Hot Root, thyme, clove, tangerine, licorice, chamomile, prune, meadowsweet, purple Japanese bark, oak, grapefruit, thorn pear, lemon, kiwi, pine, neem, Artichoke, horsetail, barnyard grass, evening primrose, bilberry, butterbur, and akke Perilla, white willow, saxifrage, centella, rosemary, lavender, and Preferably, one or more selected from the group consisting of extracts extracted from Cornus japonica, Placenta; Arbutin; Kojic acid; Phytic acid; Tranexamic acid; Hydroquinone; Ascorbic acid, sodium ascorbate, sodium ascorbyl phosphate , magnesium ascorbyl phosphate, ascorbic acid tetra-2-hexyldecanoate Ascorbic acid, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glycerin Glucoside; Vitamin A Oil; Iris Root Extract, Almond Oil, Aloe Vera Extract, Acerola Extract, Angelica Root Extract, Scutellaria Baicalensis Extract, Hypericum Perforatum Extract, Nettle Green Extract, Seaweed extract, Pueraria lobata extract, Chamomile extract, Peony extract, Sophora ulmoides extract, Soybean extract, tea extract, white tea extract, calendula, witch hazel, coix seed , Job's tears extract, hop extract, prune extract, licorice extract, oil-soluble licorice Kisu, Meadowsweet extract, Purple bark extract, Alpinia cutletfish seed extract, Grapefruit extract, Rosa rosa extract, Lemon extract, Kiwi extract, Eyelash extract Neem leaf extract, artichoke extract, horsetail extract, bark extract, Japanese pine Night primrose extract, evening primrose oil, bilberry leaf extract, Geranium extract, Salicornia extract A group consisting of citric acid, white willow extract, Centella asiatica extract, and Cornus cherry fruit extract It is more preferable to use one or more selected from the following.

[0075] When the above-described whitening ingredients are blended into the skin external composition of the present invention, the content of the ingredients is The amount of the composition for external use on the skin can be selected appropriately taking into consideration the feeling of use and the effect on the skin. The plant extract is present in an amount of about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. When using the above, the content is calculated as the amount of extract, etc., relative to the total amount of the topical skin composition. For example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, more preferably about 0.0001 to 15% by mass. More preferably, it is 0.001 to 10% by mass.

[0076] Anti-inflammatory ingredients include, for example, allantoin, calamine, tranexamic acid, and glycyrrhizin. glycyrrhizinic acid or its derivatives or their salts (e.g., dipotassium glycyrrhizinate, glycyrrhizin Monoammonium cyrrhizate, etc.), glycyrrhetinic acid or its derivatives or Salts (e.g., glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, amino Caproic acid, azulene and its derivatives (e.g., guaiazulene, azulene, etc.), vinegar Tocopherol, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin salicylic acid or its derivatives, steroids or their derivatives or their salts (e.g. For example, hydrocortisone, prednisolone), ufenamate, bufexamac, ibuprapone Lofenpiconol, glycol salicylate, botanicals (e.g., comfrey, coptis, dodder) The anti-inflammatory component is preferably alanine. Inosin, Tranexamic acid, Dipotassium glycyrrhizinate, Monoammonium glycyrrhizinate , glycyrrhetinic acid, stearyl glycyrrhetinate, aminocaproic acid, azulene and one or more selected from the group consisting of azulene and its derivatives, azulene and its derivatives, and Houttuynia cordata extract are two or more kinds, and more preferably, allantoin, tranexamic acid, glycyrrhizin one or two selected from the group consisting of dipotassium carbonate, glycyrrhetinic acid, and aminocaproic acid When anti-inflammatory ingredients are added, the amount of each ingredient should be determined taking into consideration the feel and effect on the skin. The amount of the topical composition for skin of the present invention can be appropriately selected, for example, about 0.000 The content is 3 to 10% by mass, preferably about 0.01 to 5% by mass.

[0077] Examples of antibacterial or antiseptic components include chlorhexidine, salicylic acid, and benzyl chloride. Zr, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylpheno ol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, Phenoxyethanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, chloride Cetyltrimethylammonium, piroctoolamine, zinc pyrithione, miconazole or its salts, chlorobutanol, glyceryl caprylate, ethylhexylglycerin, Propynyl iodide butylcarbamate, caprylhydroxamic acid, phenethyl alcohol , methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, azelaic acid, plant ( For example, ingredients derived from sophora flava, rosemary, mulberry, eucalyptus, etc. may be mentioned. Among them, salicylic acid, benzalkonium chloride, ethanol, cetylpyridinium chloride, Cetyltrimethylammonium chloride, gluconic acid, isopropylmethylphenol, para Ben, phenoxyethanol, cetylpyridinium chloride, zinc pyrithione, chlorobutadiene Alcohol, Ethylhexylglycerin, Iodopropynyl Butylcarbamate, Caprylyl Hydroxamic acid, sorbic acid, β-glycyrrhetinic acid, rosemary extract, eucalyptus extract It is preferable to use one or more selected from the group consisting of antibacterial and bactericidal components. When using the skin care product, the content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0003 to 10% by mass, preferably about 0.0003 to 10% by mass, based on the total amount of the composition for external use on skin. It is 0.001 to 5 mass %.

[0078] Examples of the cooling agent include menthol and its derivatives, camphor, borneol, and gelatin. Terpenes such as lanthanide, cineole, anethole, limonene, and eugenol (these may be in the d-, l- or dl-form; eucalyptus oil, bergamot oil, peppermint oil Coconut oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose Among them, l-menthol, menthyl glyceryl ether, and essential oils such as turpentine are particularly preferred. ester, menthyl lactate, menthyl 3-hydroxybutyrate, menthoxypropanediol Combination with citric acid, camphor, eucalyptus oil, peppermint oil, and peppermint oil is preferred. When a cosmetic agent is added, its content can be appropriately selected taking into consideration the feel and effect on the skin. For example, 0.001 to 5% by mass or more, preferably 0.001 to 5% by mass or more, based on the total amount of the external skin composition of the present invention. The content is preferably 0.005 to 3 mass % or more, and more preferably 0.01 to 1 mass % or more.

[0079] Examples of the organic acid include gluconic acid, aspartic acid, and aminoethylsulfonic acid. , citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, Propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, Pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid , glutamic acid, azelaic acid, and salts thereof. Examples of salts include sulfuric acid. salts of mineral acids such as hydrochloric acid or phosphoric acid; salts of organic acids such as maleic acid or methanesulfonic acid; Alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts, basic Examples include amino acid salts and amine salts such as triethanolamine. Among these, gluconic acid , citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytin It is preferable to use a combination of one or more selected from the group consisting of lactic acid, tartaric acid, glycyrrhetinic acid, and lactic acid. More preferable.

[0080] Examples of anti-glycation ingredients include Budreja axillaris leaf extract, plum fruit extract, and -Delweiss extract, ginkgo extract, cherry leaf extract, pomegranate extract, osmanthus leaf extract Co-extract, Hawthorn extract, Peony extract, Houttuynia cordata extract, Bilberry leaf Extract, green tea extract, black tea extract, horse chestnut extract, Roman chamomile extract, mugwort extract Plant extracts such as ginger, evening primrose oil, amla fruit, fruit juice or their extracts, L-arginine Examples of such compounds include lysine, L-lysine, hydrolyzed casein, hydrolyzed tannins, and carnosine. When anti-glycation ingredients are added, the amount of content can be selected appropriately taking into consideration the feel and effect on the skin. However, for example, about 0.0003 to 10% by mass of the total amount of the external skin composition of the present invention. The content is preferably about 0.001 to 5% by mass.

[0081] Examples of cell activating components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid. Acids: retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, pyrophosphate Vitamins such as quinolinones; gluconic acid, phytic acid, glycolic acid, lactic acid, etc. alpha-hydroxy acids; tannins, flavonoids, saponins, allantoin, placenta Ta, proteoglycan, photosensitizer No. 301, plants (e.g., soybean, bilberry, lemon) Grass, aloe vera, chlorella, beadle, coix seed, chamomile, Houttuynia cordata, hops, Ingredients derived from carrots, etc.; royal jelly, royal jelly extract; whey, yogurt Examples include whey-derived extracts such as gluten extract, hydrolyzed milk protein, and yeast extract. When cell activation ingredients are included, the amount of content is selected appropriately taking into consideration the feel and effect on the skin. However, for example, about 0.0003 to 10 mass % of the total amount of the external skin composition of the present invention. %, preferably about 0.001 to 5% by mass.

[0082] Astringent ingredients include, for example, alum, chlorohydroxyaluminum, and aluminum chloride. Sodium, Allantoin Aluminum Salt, Zinc Paraphenolsulfonate, Zinc Sulfate, Sulfate Metal salts such as aluminum potassium and basic aluminum zinc lactate; tannic acid, citric acid , organic acids such as lactic acid and succinic acid, plants (e.g., seaweed, thyme, black tea, oolong tea, green tea, St. John's wort, Hamamelis, Loquat, Peony, Saxifraga, Rooibos, Chinese milk vetch, Ardisia crenata (tea choke, chamomile, eucalyptus, lemon, rosemary, burnet, etc.) When astringent ingredients are included, their content is determined based on the feel and effect on the skin. The amount can be appropriately selected taking into consideration the above, but it may be, for example, about 0. The content is 0.003 to 20% by mass, preferably about 0.01 to 10% by mass.

[0083] Examples of antioxidant components include butylhydroxyanisole and dibutylhydroxytoluene. Ene, sodium hydrogen sulfite, sodium pyrosulfite, erythorbic acid and its salts, asparagus Corbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, Glutathione-S-transferase, catalase, superoxide dismutase , thioredoxin, taurine, thiotaurine, hypotaurine, plants (e.g., Hypericum perforatum) , Pueraria lobata, bilberry, Scutellaria baicalensis, passionflower, grapefruit, peony Medicago sativa, meadowsweet, perilla, honeysuckle, sage, yarrow, mallow, Motsukesou, mulberry, clove, chinpi, dwarf butterbur, loquat, safflower, peonies, Hops, eucalyptus, saxifrage, rooibos, lemongrass, soybean, mugwort, and matsuyoi These include ingredients derived from herbs, rosemary, lavender, etc. When the amount of the active ingredient is added, the amount of the active ingredient can be appropriately selected in consideration of the feeling on the skin and the effect of the active ingredient. For example, about 0.00001 to 10% by mass, preferably about 0.00001 to 10% by mass, based on the total amount of the topical skin composition. The content is 0.0001 to 5% by mass, and more preferably 0.001 to 5% by mass.

[0084] Anti-aging ingredients include, for example, hydrolyzed soy protein, retinoids (retinol, thinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingomyelin Syn derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (Caprooyl tetrapeptide-3, oligopeptide-24, etc.), plants (artichoke Wood, Rosa rosa, seaweed, bilberry, birch, plantain, angelica, and scutellaria St. John's wort, comfrey, neem, wild rose, beadle, geranium, linden, Among them, hydrolyzed soy protein, retinol, retinol acetate Retinol Palmitate, Caprooyl Tetrapeptide-3, Oligopeptide-24 , artichoke leaf extract, seaweed extract, bilberry leaf extract, comfrey leaf extract, Neem leaf extract and Geranium globulus extract are preferred. If anti-aging ingredients are included, their content The amount can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass, based on the amount is.

[0085] Moisturizing ingredients include, for example, alanine, serine, aspartic acid, glycine, and proline. , hydroxyproline, glucosamine, theanine, arginine, and other amino acids and their derivatives Conductors; polyhydric alcohols such as glycerin, dipropylene glycol, and 1,3-butanediol sorbitol, xylitol, erythritol, maltose-sucrose condensates (glucose sugar alcohols such as xylooligosaccharides, hydrolyzed xylans (xylooligosaccharides); glycosyl Ceramide, glucosylceramide, cholesterol, phytosulfate sterols, cholesterol derivatives, phytosterol derivatives; lecithin, hydrogenated lecithin Phospholipids such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea, etc. NMF-derived ingredients, hyaluronic acid (including hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, etc.) ); Salts of hyaluronic acid (e.g., sodium hyaluronate, zinc hyaluronate, low molecular weight hyaluronate, Zinc hyaluronate, etc.; hyaluronic acid derivatives (acetylated hyaluronic acid or its salts (e.g., , acetylated sodium hyaluronate, acetylated zinc hyaluronate, etc.), cross-linked hyaluronic acid Hyaluronic acid derivatives (sodium hyaluronic acid crosspolymer, etc.), carboxymethyl hyaluronic acid N a. Unsaturated hyaluronic acid or its salt, hydrolyzed alkyl hyaluronate (C12-13) Lyceryl, cationized hyaluronic acid derivative (hydroxypropyltrimonium hyaluronate) hydroxybenzoates, etc.), hyaluronic acid dimethylsilanol, etc.); chondroitin sulfate or its salts (chondroitin Sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatan sulfate, lumatin sulfate potassium, etc.); collagen, elastin, keratin, chitin, chitosan, etc. their hydrolysates; hydroxyethyl urea; plants (e.g., aloe, seaweed, Chlorella, lemongrass, chamomile, witch hazel, tea, perilla, grapefruit, Among them, glycine, arginine, Glycerin, dipropylene glycol, 1,3-butanediol, glycosyl trehalose Ceramide, glucosylceramide, cholesterol, cholesterol derivatives, phytosulfate Lactic acid, sodium lactate, pyrrolidone carboxylic acid sodium, lactic acid derivatives, hydrogenated lecithin Sodium, urea, hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, sodium hyaluronate, Zinc hyaluronate, low molecular weight zinc hyaluronate, acetylated hyaluronic acid, hyaluronic acid crystals Loss polymer sodium, hydroxypropyltrimonium hyaluronate, dimethicone hyaluronate Lucilanol, collagen, elastin, keratin, hydroxyethyl urea, seaweed extract One or two selected from the group consisting of chamomile extract, witch hazel extract, and gynostemma pentaphyllum extract The above is preferable, and from the viewpoint of improving the feeling of use, hyaluronic acid or a salt thereof, hyaluronic acid One or more selected from the group consisting of derivatives and chondroitin sulfate or its salts When a moisturizing ingredient is added, its content should be determined taking into consideration the feel and effect on the skin. The amount of the external skin composition of the present invention can be appropriately selected, for example, about 0.001 The content is about 0.01 to 20% by mass, preferably about 0.01 to 10% by mass.

[0086] Examples of polyhydric alcohols include diols having 2 to 4 carbon atoms or 11 or more carbon atoms, hydroxyl Examples of suitable alcohols include polyhydric alcohols having three or more groups, such as glycerin, diglycerin, triglyceride, and the like. Diglycerin, propylene glycol, dipropylene glycol, ethylene glycol, Diethylene glycol, isoprene glycol, 1,3-butylene glycol, 1,3- propanediol, among others. Glycerin, diglycerin, propylene glycol One or two selected from the group consisting of dipropylene glycol, 1,3-butylene glycol When polyhydric alcohol is added, its content should be adjusted to the extent that it is applied to the skin. The amount of the composition for external use on skin of the present invention can be appropriately selected taking into consideration the feeling of use and the moisturizing effect. For example, the content is about 0.1 to 20% by mass, preferably about 0.5 to 15% by mass.

[0087] Examples of keratin softening ingredients include lanolin, urea, phytic acid, lactic acid, lactate, and glycosides. Acid, salicylic acid, malic acid, citric acid, fruit acid, tartaric acid, succinic acid, oxalic acid, gluconic acid, ferulic acid, sulfur, etc. Among them, lactic acid, sodium lactate, glycol Selected from the group consisting of cholic acid, salicylic acid, phytic acid, citric acid, and gluconic acid It is preferable to use one or more kinds. When a keratin softening ingredient is added, the content of the ingredient should be determined based on the amount of the ingredient used on the skin. It can be appropriately selected taking into consideration the feeling of use and the effect. For example, 0.0001 to 50% by mass, preferably about 0.001 to 50% by mass, more preferably is about 0.01 to 25% by mass.

[0088] Vitamins include, for example, retinol, retinol acetate, and retinol palmitate. , retinol derivatives such as retinol propionate and retinol linoleate, retinal, Retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d -δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate Vitamin A such as thiamine; β-carotene, α-carotene, γ-carotene, δ-carotene Provitamin A, such as lycopene, zeaxanthin, cryptoxanthin, and echinenone ;δ-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol, dl-α-Tocopherol calcium succinate, tocopherol nicotinate, dl- Alpha-tocopherol, tocopherol linoleate, tocopherol (linoleate / oleate) Vitamin E compounds such as ascorbyl / tocopheryl phosphate potassium; γ-oryza thiamine, and their salts (e.g., dibenzoylthiamine hydrochloride, thiamine salts) Vitamin B1 compounds such as thiamine diphosphate, thiamine diphosphate, riboflavin, flavin mononucleotide Flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrahydrofuran Butyric acid ester, riboflavin 5'-phosphate sodium ester, riboflavin tetranic acid Vitamin B2 compounds such as nicotinic acid esters and their salts; benzyl nicotinate, nicotinic acid Nicotinic acids other than component (B) above, such as methyl nicotinic acid; ascorbic acid stearate Isostearyl ascorbyl phosphate disodium, L-ascorbyl dipalmitate , ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), Trisodium Ascorbyl Palmitate Phosphate, Ascorbic Acid, Sodium Ascorbate Ascorbic acid, dehydroascorbic acid, sodium ascorbyl phosphate, ascorbic acid Magnesium ascorbate phosphate, ascorbic acid glucoside, 2-O-ethyl ascorbyl Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Glyceryl Ascorbate, Bisglyceryl Ascorbate Ascorbic Acid, Hexyl 3-Glyceryl Ascorbate, 3-Glyceryl Ascorbate , Myristyl 3-glyceryl ascorbate, 3-laurylglyceryl ascorbate, Ascorbyl / Tocopheryl Phosphate, Potassium Ascorbyl / Tocopheryl Phosphate Vitamin C compounds such as ascorbyl maleate, methyl hesperidin, Vitamin D derivatives such as ergocalciferol and cholecalciferol; phylloquinone, Vitamin K derivatives such as thiamine, thiamine, and their salts (e.g., dibenzoylthiamin, Vitamin B1 compounds such as thiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate, etc.; pyridinium hydrochloride pyridoxine, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal 5'-phosphate, pyridoxal hydrochloride Vitamin B6 such as lidoxamine, cyanocobalamin, hydroxocobalamin, deoxycobalamin Vitamin B12 compounds such as adenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid Pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantetheine, D-pantethine, coenzyme A, pantothenyl ethyl ether, pantethe Pantothenic acids such as calcium isosulfonate; biotins such as biotin and biocytin; Other ingredients include carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, and pyrophosphate. quinoline quinone, hesperidin and glucosyl hesperidin, ubiquinone, and Vitamin-like factors such as salts are also included. One or two selected from the group consisting of vitamin E, vitamin A, and vitamin-like action factors The above are preferred, and pyridoxine hydrochloride, pantothenyl alcohol (panthenol), livof Rabin, cyanocobalamin, ascorbic acid, ascorbic acid glucoside, 3-O-ethyl Ascorbic acid, sodium ascorbyl phosphate, ascorbyl phosphate Magnesium ester, dl-α-tocopherol acetate, ascorbyl palmitate Tetra-2-hexyldecanoate ascorbyl, retinol, retinol palmitate , retinol propionate, retinol acetate, pyrroloquinoline quinone or its salt, ubiquitin A combination of one or more selected from the group consisting of non-oryzanol and γ-oryzanol is more preferred. When vitamins are added, the amount should be selected appropriately taking into consideration the feel and effect on the skin. For example, about 0.001 to 30 mass % of the total amount of the topical skin composition of the present invention can be selected. %, preferably about 0.01 to 25% by mass, more preferably about 0.01 to 20% by mass. be.

[0089] Examples of blood circulation promoting ingredients include plants (e.g., ginseng, angelica tree, arnica) , ginkgo, fennel, emmeisou, Dutch oak, chamomile, Roman chamomile, Rotthorn, gentian, burdock, rice, hawthorn, shiitake mushroom, ginger, and oak Zashi, Juniper, Cnidium, Swertia, Thyme, Clove, Chinese ginseng, Angelica sinensis, and Japanese angelica Nin, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, Melissa, yuzu, coix seed, rosemary, rosehip, peach, apricot, walnut, Ingredients derived from corn: dl-α-tocopherol acetate, tocopherol nicotinate Glucosyl hesperidin, hesperidin, caffeine, capsicum tincture, gamma-oligosaccharides These include benzoyl alcohol, capsaicin, and nicotinic acid benzyl ester. When blended, the content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.00001 to 10% by mass, preferably about 0.00001 to 10% by mass, based on the total amount of the topical skin composition. The content of plant-derived cellulose is 0.0001 to 5% by mass, and more preferably about 0.001 to 5% by mass. When using natural ingredients, the content is calculated as an extract, etc., relative to the total amount of the topical skin composition. For example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass %, and more preferably 0.001 to 10% by mass.

[0090] Examples of sebum-absorbing ingredients include talc, mica, hydroxyapatite, zinc oxide, Aluminum silicate and the like are included, and preferably mica, hydroxyapatite, and One or more selected from the group consisting of zinc oxide, and particularly preferably mica. When incorporating sebum-absorbing ingredients, the amount of content should be selected appropriately taking into consideration the feel and effect on the skin. For example, about 0.001 to 35 mass % of the total amount of the external skin composition of the present invention can be selected. %, preferably about 0.1 to 25% by mass.

[0091] Examples of peptides or derivatives thereof include keratin decomposition peptides and hydrolyzed keratin. , collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, Gelatin, elastin, elastin decomposition peptides, collagen decomposition peptides, hydrolyzed collagen collagen, hydroxypropyl ammonium chloride hydrolyzed collagen, elastin hydrolyzed Peptide, conchiolin decomposition peptide, hydrolyzed conchiolin, silk protein decomposition peptide, Hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein hydrolyzed peptide, dehydrated Soy protein, wheat protein, wheat proteolysis peptides, hydrolyzed wheat protein, casein hydrolysis peptides Peptides, acylated peptides (palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl Among them, keratin hydrolysis peptides, hydrolysis peptides, etc. Keratin, fish-derived collagen elastin, elastin decomposition peptide, collagen decomposition peptide Tide, hydrolyzed collagen, succinylated atelocollagen, elastin degradation peptide, One or more selected from hydrolyzed silk, soy protein hydrolyzed peptide, and hydrolyzed soy protein When peptides or their derivatives are blended, the content should be adjusted according to the amount of the peptide or its derivatives used on the skin. It can be appropriately selected taking into consideration the feeling of use and the effect. For example, it is about 0.0001 to 35% by mass, and preferably about 0.001 to 10% by mass.

[0092] Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline hydroxyproline, arginine, lysine, serine, glycine, alanine, phenyl Alanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, asparagine Paragic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, Styridine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybenzoic acid Glucocorticoid, Carnitine, Carnosine, Creatine, Epsilon Aminocaproic Acid, Triptophan Tophan, Ornithine, Phytosteryl / Octyldodecyl Lauroyl Glutamate ), di(octyldodecyl / phytosteryl / behenyl) lauroyl glutamate, etc. These amino acids or derivatives thereof may also be in the form of solvates such as hydrates. Furthermore, it may be any of d-, l- or dl-forms. Among these, the l-form amino acid or its derivatives One or more selected from the following are preferred.

[0093] In addition to the components (A) to (C), the skin external composition of the present invention may further contain the above-mentioned components. Depending on the application or dosage form, it is usually used in the fields of pharmaceuticals, quasi-drugs, or cosmetics. The ingredients that can be blended are not particularly limited, but examples include , base or carrier, surfactant, thickener, antioxidant, preservative, pH adjuster, Additives such as thickeners, stabilizers, irritation reducers, colorants, dispersants, and fragrances can be added. These ingredients may be used alone or in any combination of two or more. The content of these components can be adjusted within a range known in the art without impairing the effects of the present invention. Furthermore, if the following multiple components are present, It can be added as an ingredient for any of the functions.

[0094] The base or carrier may be an aqueous base such as water; liquid paraffin, liquid isoparaffin, Quaran, Vaseline, Paraffin, Microcrystalline Wax, Polybutene, Polyethylene Styrene powder, gelled hydrocarbon (Plastibase, etc.), ozokerite, α-olefin oligomer hydrocarbons such as methyl polysilane, light liquid paraffin, and light iso-liquid paraffin; Siloxane, cross-linked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone , alkyl-modified silicone, cross-linked alkyl-modified silicone, amino-modified silicone, poly Polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone Silicone, cross-linked alkyl polyether modified silicone, silicone / alkyl chain co-modified Polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone Polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic Silicone oils such as silicone, phenyl-modified silicone, silicone resin; Cetano cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyl Dodecanol, isostearyl alcohol, phytosterols, cholesterol Higher alcohols: isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid Higher fatty acids such as phosphoric acid and behenic acid; carboxymethyl cellulose, hydroxyethyl cellulose ethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl cellulose derivatives such as methyl cellulose; polyvinylpyrrolidone; polyvinyl butyrate Polyethylene glycol; Dioxane; Butylene glycol adipate polyester ester; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate propyl, cetyl palmitate, isononyl isononanoate, tetra-2-ethylhexanoic acid pentaerythritol Pentaerythritol, diisopropyl adipate, decyl oleate, isodecyl oleate Hexyldecyl dimethyloctanoate, diisopropyl sebacate, di-2-hydroxybenzoate -Ethylhexyl, 2-hexyldecyl myristate, 2-hexyldecyl palmitate , diisopropyl adipate, isotridecyl isononanoate, cetyl lactate, isostearyl Isostearyl phosphate, cholesteryl 12-hydroxystearate, cholesteryl stearate Steryl, Cholesteryl Oleate, Macadamia Nut Fatty Acid Phytosteryl, Olein Phytosteryl acetate, dextrin palmitate, inulin stearate, hydrogenated jojoba Oil, Di-2-ethylhexyl ethylene glycol, Dipentaerythritol fatty acid esters ester, neopentyl glycol dicaprate, tri-2-ethylhexyl trimellitate, Tridecyl trimellitate, trimethylolpropane tri-2-ethylhexyl ester, triisopropyl acrylate Trimethylolpropane stearate, pentaerythritol tetra-2-ethylhexanoate ethanol, glycerin tri-2-ethylhexanoate, trimethylol propionate triisostearate propane, caprylic / capric triglyceride, caprylic / capric triglyceride Glyceryl myristic acid / stearic acid, oleyl oleate, lauroyl glutamine Phytosteryl / Octyldodecyl Lauroyl Glutamate, Dioctyldodecyl Lauroyl Glutamate Cetyl / Phytosteryl / Behenyl), Triethyl Citrate, Dimer Dilinoleic Acid (Phytosteryl / Phytosteryl / Behenyl), Tosteryl / Isostearyl / Cetyl / Stearyl / Behenyl), Dimer Dilinoleic Acid Dimer dilinoleyl, dipentaerythrityl tri-polyhydroxystearate, tri( Esters such as glyceryl behenate / isostearate / eicosanedioate; jojoba Oil, Miu wax, Candelilla wax, Rice bran wax, Cotton wax, Carnauba wax, Lanolin, etc. Waxes; avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil, Leaves oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower Almond oil, shea butter, camellia oil, rapeseed oil, sesame oil, cocoa butter, coconut oil, hardened Coconut oil, palm oil, palm kernel oil, Japan wax kernel oil, Japan wax, wheat germ oil, rice germ oil, rice nu Oils and fats such as corn oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, etc.; dextrin, maltodextrin vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; methyl alcohols; lower alcohols such as ethanol and isopropanol; sorbitol, Examples include sugar alcohols such as xylitol, erythritol, and mannitol; and water. These components may be used alone or in combination of two or more. The amount used is appropriately selected from the range known to those skilled in the art. The topical skin composition of the present invention contains a cellulose derivative as a base or carrier. When the composition for external use on skin of the present invention contains water, the content of water is preferably The amount of the external skin composition of the present invention varies depending on the amount of the external skin composition, and is not particularly limited. For example, The water content is preferably 5 to 99%, more preferably 8 to 95%, and even more preferably Usually it is 10-90%.

[0095] Examples of surfactants include sorbitan monoisostearate and sorbitan monosterate. Diglycerol sorbitan tetra-2-ethylhexyl ester, sorbitan monoiodate sorbitan monoisostearate, sorbitan monolaurate, etc. Fatty acid esters; Polyoxyethylene (20) sorbitan monolaurate, monolaurate Polyoxyethylene (80) Sorbitan Monostearate, Polyoxyethylene (2 0) Sorbitan, Polyoxyethylene Monooleate (20) Sorbitan, Isostearyl Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan Glycerin monooleate, glycerin monostearate, and glycerin mono Glycerin fatty acid esters such as myristate; monoisostearyl glyceryl ether; Glycerin alkyl ethers such as monomyristyl glyceryl ether; diglyceryl mono Stearate, Decaglyceryl Decastearate, Decaglyceryl Decaisostearate and polyglycerol fatty acid esters such as diglyceryl diisostearate; monostearate Propylene glycol fatty acid esters such as propylene glycol phosphate; polyoxyethylene Polyethylene hydrogenated castor oil 40, Polyoxyethylene hydrogenated castor oil 50, Polyoxyethylene hydrogenated Hydrogenated castor oil derivatives such as hydrogenated castor oil 60 and polyoxyethylene hydrogenated castor oil 80; Polyoxyethylene glycerin fatty acid esters such as oxyethylene monococonut oil fatty acid glyceryl ether; polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether; Polyoxyethylene (20) Phytosterol, Polyoxyethylene (30) Phytosterol Roll, Polyoxyethylene (25) Phytostanol, Polyoxyethylene (30) Polyoxyethylene sterols such as Restanolic, hydrogenated sterols; sucrose fatty acid esters esters; alkyl phosphate ester salts, N-acyl amino acid salts, acylated taurates; esters Amines such as allylamine and oleylamine; Polyoxyethylene methylpolysiloxane San Copolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, PEG-9 Silicone surfactants such as polydimethylsiloxyethyl dimethicone or lecithin , hydrogenated lecithin, saponin, sodium surfactin, cholesterol, bile acid, etc. Examples of surfactants include those derived from natural sources.

[0096] Examples of thickeners include polyvinyl alcohol, polyvinylpyrrolidone, and polyvinyl Vinyl thickeners such as methyl ether and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxy Hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxymethyl cellulose cellulose-based thickeners such as carboxyethyl cellulose, dextran, acrylic acid Alkyl methacrylate copolymer, sodium polyacrylate, bentonite, dextrin Fatty acid ester, dimethyl distearyl ammonium hectorite, polyethylene glycol Chole, Macrogol, (Hydroxyethyl acrylate / Acryloyldimethyl taurine Na) Copolymer, (Ammonium Acryloyldimethyltaurate / Vinylpyrrolidone) copolymers and the like. Among them, acrylic acid alkyl methacrylate copolymer, hydroxyethyl cellulose, Hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxyvinyl Polymer, Dimethyl Distearyl Ammonium Hectorite, (Hydroxyethyl Acrylates Acryloyldimethyltaurine / Na Acryloyldimethyltaurate Copolymer, (Acryloyldimethyltaurine A ammonium / vinylpyrrolidone copolymer is preferred.

[0097] Examples of antioxidants include dibutylhydroxytoluene and butylhydroxyanisole. Sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol Erythorbic acid, sodium erythorbate, L-sodium erythorbate, tocopherol derivatives, Staphylococcus aureus hydrochloride, ubiquinones such as coenzyme Q10, lignans such as sesamin, curcumin Min, capsaicin, gingerol, resveratrol, anthocyanin, cyanidin, Examples include bilberry extract and analogs or derivatives thereof.

[0098] Preservatives or antiseptics include, for example, benzoic acid, sodium benzoate, dehydroacetic acid, Sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate Pill, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, proparahydroxybenzoate Pill, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol , benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorohexyl gluconate Xyzidine, methylisothiazolinone, propyl iodide butylcarbamate, caprylamide Hydroxamic Acid, Phenethyl Alcohol, Ethylhexylglycerin, Glyceryl Caprate Examples of preservatives include methylphenol and isopropyl methylphenol. The content of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001% by mass to 5% by mass, preferably about 0.01% by mass to 5% by mass, based on the total amount of the substance. It is 1% by mass.

[0099] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, etc.), citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), potassium carbonate, sodium bicarbonate, diacid Carbon hydride, organic bases (triethanolamine, diisopropanolamine, triisopropanolamine) phenolamine, etc.

[0100] Examples of chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediamine Disodium edetate tetraacetate (sodium salt (disodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.) , potassium salts, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc. Among these, sodium edetate is preferred.

[0101] Examples of stabilizers include sodium polyacrylate and dibutylhydroxytoluene. , butylhydroxyanisole, and the like.

[0102] Examples of irritation reducers include licorice extract and polyvinylpyrrolidone.

[0103] [viscosity] The viscosity (25°C) of the topical skin composition of the present invention is in the range of 1 to 500,000 mPa·s. If any, there is no particular limitation, but from the viewpoint of significantly exhibiting the effects of the present invention, it is preferable that the 500,000 mPa·s, more preferably 5 to 450,000 mPa·s, and even more preferably is 100 to 400,000 mPa·s, and even more preferably 200 to 300,000 mPa·s a·s, and particularly preferably 500 to 300,000 mPa·s. By appropriately selecting the type and content of a thickener, it is possible to obtain a topical skin composition having such viscosity. can be obtained.

[0104] In the present invention, the viscosity is measured according to the viscosity test method described in the 17th edition of the Japanese Pharmacopoeia. The measurement is performed using a single cylindrical rotational viscometer (Brookfield type viscometer) in accordance with the measurement method of this application. We used TV-10M (Toki Sangyo) and selected the rotor, rotation speed, etc. Measure the viscosity at 25°C according to the instruction manual. Instructions for the single cylinder rotational viscometer The single cylinder rotational viscometer rotates a cylinder in a liquid at a constant angular velocity. This is a viscometer that measures the torque of the viscometer. By determining the constant KB, the viscosity η of the liquid is calculated by the following formula: η=KB × T / ω η: Viscosity of the liquid (mPa·s) KB: Equipment constant (rad / cm3) ω: Angular velocity (rad / s) T: Torque acting on the cylindrical surface (10-7 N m)

[0105] [pH] The composition for external application to the skin of the present invention may generally have a pH of 2.0 to 9.0. From the viewpoint of low irritation to the skin and mucous membranes and a pleasant feel on the skin, a pH of 3 is preferable. The pH is preferably 4.0 to 8.5, and more preferably 4.0 to 8.0.

[0106] [Method of manufacturing a composition for external use on skin] The method for producing the topical skin composition of the present invention is not particularly limited, and in addition to the above components (A) to (C), The other ingredients mentioned above are appropriately selected and mixed, and emulsified as necessary in a conventional manner to produce the product. It can be made.

[0107] [Properties and formulation] The form of the external skin composition of the present invention is not particularly limited, and may be liquid, fluid, or semi-solid. The formulation may be, for example, a liquid, a suspension, an emulsion, a cream, Emulsion, ointment, gel, liniment, lotion, aerosol, spray, nonwoven It can be formulated as a sheet in which a cloth is impregnated with a drug solution. A cream, emulsion, ointment, gel, lotion, or sheet is preferred. Particularly preferred are emulsions, emulsions, gels, lotions, and sheets. When a drug contains both an oily base and an aqueous base, such as a cream or ointment, it can be either a W / O type or an O / W type. However, from the viewpoint of ensuring a suitable viscosity of the topical skin composition of the present invention and the feeling of use (stickiness), In terms of properties such as spreadability, moist feeling, freshness, and penetration, the O / W type is more preferred.

[0108] [Usage] Specific uses of the composition for external use as a quasi-drug or cosmetic include, for example: Lotion, emulsion, gel, cream, serum, sunscreen, pack, mask, hand Cream, all-in-one gel, all-in-one cream, body lotion, and body Basic cosmetics such as creams; as well as facial cleansers, hand soaps, makeup removers, and body lotions. - Cleansing cosmetics such as shampoo, conditioner, and treatment, fan Face makeup cosmetics such as foundation, BB cream, CC cream, etc. Lip cosmetics such as lip balm and lip liner; Hair rinse and hair treatments Toment, hair conditioner, hair gel, hair mousse, hair mist, hair lotion Among these, the most popular are skin care products such as hair styling products and hair care products. That is, the topical composition of the present invention is a pharmaceutical product, a quasi-drug product, or The external skin composition can be prepared as a cosmetic composition. The same applies as for external use compositions. Also, the base or carrier, additives, and active ingredients that can be used and their preferred ones are the same as those in the topical composition of the present invention.

[0109] [container] The topical skin composition of the present invention can be packaged in a container of a shape and material appropriately selected depending on the purpose and application of the composition. Specific containers include spray types, bottles, etc. Tor type, tube type, jar type, dropper type, dispenser type, Examples of the external skin composition of the present invention include a stick type, a pouch bag, and a cheer pack. The product can be used in a desirable state from the viewpoint of ease of removal from the container, so it is highly concentrated. This allows for greater freedom in formulation design, including high concentrations of nicotinamide. Even with nicotinamide-containing formulations, the product can be used in spray bottles, tubes, and jars. This makes it easy to use in a wide variety of containers, such as tubes and dispensers.

[0110] The container material is polyethylene terephthalate, polypropylene, polyethylene Polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin Examples include plastic, polystyrene, glass, and metal (aluminum, etc.). The material is subjected to various coating treatments, taking into consideration strength, flexibility, weather resistance, and stability of the components. These materials can be combined, for example, by mixing, or layered to form a container. The coating material can be epoxy resin, polyamide, etc. Among them, polypropylene, polyethylene (HDPE, LDP) Ethylene vinyl alcohol resin, metal (aluminum, etc.) can be used. preferable.

[0111] [How to use etc.] The topical skin composition of the present invention is expected to have the following effects: promoting blood circulation, anti-inflammatory properties, etc., due to the physiological activity of nicotinamide. It can be suitably used for the purpose of whitening, anti-wrinkle, anti-aging, and promoting ceramide synthesis. It is expected to have a brightening effect and is useful as a multi-functional formulation, including as a whitening agent and sunscreen. The topical skin composition of the present invention can be administered once or several times a day depending on the intended use. It can be used in known or customary dosages and administration. [Example]

[0112] Next, the present invention will be specifically described with reference to examples and test examples. It is not limited to the examples.

[0113] [Test Example 1. Verification test for suppressing viscosity decrease due to heat - 1] Samples with the compositions shown in Table 1 below were prepared. Each sample was filled in a glass bottle in an amount of 20 mL. The sample was stored at 60°C for one week (equivalent to one year of storage at room temperature). The viscosity of the sample was measured before and after storage. Using a viscometer (BL type) (Model TV-10M, manufactured by Toki Sangyo Co., Ltd.), Comparative Examples 1-1 and 1- In Examples 2 and 1-1 to 1-3, an M3 rotor was used, and in the other cases, an M2 rotor was used at 25°C for 6 r The measurement was carried out for 1 minute at a rotation speed of 10 ... The same is shown in Table 1. <Viscosity reduction rate> Viscosity reduction rate (%) = (Viscosity before storage - Viscosity after storage) / Viscosity before storage × 100

[0114] [Table 1]

[0115] Comparative Examples 1-1 and 1-2, and Comparative Examples 1-3 and 1-4 show that nicotinic acid amide is used in water-soluble polysaccharides. It was found that the addition of α-glucan accelerated the decrease in viscosity of the composition after storage, and increased the viscosity decrease rate. On the other hand, as in Examples 1-1 to 1-3, gellan gum and nicotinamide are further mixed with polysaccharides. Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B. O.)(8E.O.)(5P.O.), polyethylene methyl glucoside, or PPG-1 4 When polyglyceryl-2 ether was added, the viscosity reduction rate was smaller than that of Comparative Example 1-2. As a result, the decrease in viscosity of the gellan gum-containing composition caused by nicotinamide is suppressed. was shown.

[0116] Similarly, as in Examples 1-4 and 1-5, agar and nicotinamide were further added with (C) Even when the component (C) was added, the viscosity reduction rate was smaller than that of Comparative Example 1-4, which did not contain the component (C). This indicates that the decrease in viscosity of the agar-containing composition due to nicotinamide is suppressed. was shown.

[0117] In all of Examples 1-1 to 1-5, the samples after storage had a good feel when used.

[0118] On the other hand, celluloses (cellulose derivatives) can be used instead of the water-soluble polysaccharides described herein. When a certain hydroxyethyl cellulose was used, the results were as follows: As can be seen, the tendency for the viscosity reduction rate to increase with nicotinamide is the same as with gellan gum and As shown in Comparative Examples 1-7 to 1-9, the hydroxyethylcellulose was The addition of cellulose did not inhibit the viscosity reduction but rather accelerated it.

[0119] [Test Example 2. Verification test of suppression of viscosity decrease due to heat - 2] Samples with the compositions shown in Table 2 below were prepared. Each sample was filled in a glass bottle in an amount of 20 mL. The sample was stored at 60°C for one week (equivalent to one year at room temperature). After being kept at 25°C, the results were compared before and after storage. The viscosity of the sample was measured using a B-type viscometer (BL type) (Model TV-10M, manufactured by Toki Sangyo Co., Ltd.). The measurement was carried out using an M3 rotor at 25°C and 6 rpm for 1 minute. The viscosity reduction rate was calculated using the same formula as in 1. The results are shown in Table 2.

[0120] Comparative Example 1-2, which contains components (A) and (B) but does not contain component (C), and Examples 2-1 to 2-1 When compared with Comparative Example 1-0, the addition of component (C) in all Examples resulted in an improvement over Comparative Example 1-2. The viscosity reduction rate is reduced as a result, and the decrease in viscosity of the composition over time due to heat is suppressed. was shown.

[0121] In addition to the component (A), a comparative example containing 5% by mass of nicotinamide as the component (B) was also prepared. When comparing Example 2-1 with Example 2-11, which further contains component (C), the addition of component (C) By this, the viscosity of the composition due to heat does not decrease over time, as in the case where nicotinamide is 3% by mass. It was shown that the decrease in the degree of

[0122] In addition, when component (A) contains a heparinoid in addition to gellan gum (comparison Comparative Example 2-2 and Example 2-12) When xanthan gum was added to gellan gum In Comparative Example 2-3 and Example 2-13, the addition of each component (C) This indicates that the decrease in viscosity of the composition over time due to heat is suppressed.

[0123] In all of Examples 2-1 to 2-13, the samples after storage had a good feel when used.

[0124] [Table 2]

[0125] [Test Example 3: Verification test of suppression of viscosity decrease due to light from a standard light source] Samples with the compositions shown in Tables 3 and 4 below were prepared. Each sample was filled into a glass bottle in an amount of 20 mL. At 25°C, the standard light source is the D65 fluorescent lamp specified by the International Commission on Illumination (CIE). The sample was irradiated with light at 4500lx / h until the total light reached 1.2 million lx. The viscosity of M3 was measured using a B-type viscometer (BL type) (Model TV-10M, manufactured by Toki Sangyo Co., Ltd.). Using a rotor, the measurement was carried out at 25°C and 6 rpm for 1 minute. The viscosity reduction rate was calculated as follows: The results are shown in Tables 3 and 4, respectively. <Viscosity reduction rate> Viscosity reduction rate (%) = (Viscosity before irradiation - Viscosity after irradiation) / Viscosity before irradiation × 100

[0126] In Table 3, Comparative Example 3-2 contains components (A) and (B), and Comparative Example 3-3 contains component (C). When compared with Examples 3-1 to 3-16, which contain the component (C), the addition of the component (C) in each of the Examples is As a result, the viscosity reduction rate was smaller than that of Comparative Example 3-2, and the viscosity was reduced by light mainly composed of visible light. It was shown that the decrease in viscosity of the composition over time due to the addition of the hydroxybenzoates was suppressed.

[0127] In addition, in Table 4, in addition to component (A), nicotinamide was used as component (B) at 5% by mass. When nicotinamide was contained (Comparative Example 3-3 and Example 3-17), the nicotinamide content was 10% by mass. When comparing the cases where component (C) is added (Comparative Example 3-4 and Example 3-18), As a result, as with the case of 3% by mass of nicotinamide, the absorption of light with visible light as the main component was It was shown that the decrease in viscosity of the composition over time was suppressed.

[0128] In addition, when a heparinoid substance is contained in addition to gellan gum as component (A) (comparison Examples 3-5 and 3-19), when xanthan gum is contained in addition to gellan gum ( From the results of Comparative Example 3-6 and Example 3-20, it was found that adding component (C) improved the visibility. It was shown that the decrease in viscosity of the composition over time due to light, which is the main component, was suppressed.

[0129] In all of Examples 3-1 to 20, the samples after storage had a good feel when used.

[0130] [Table 3]

[0131] [Table 4]

[0132] [Test Example 4. Verification test of suppression of viscosity decrease by ultraviolet light (UV)] Samples having the compositions shown in Table 5 below were prepared. Each sample was filled in a glass bottle in an amount of 20 mL. At 35°C, Suntest XLS+ (Toyo Seiki Co., Ltd., 1700W xenon air-cooled lamp) The specimen was irradiated with ultraviolet light at an intensity of 765 W / m2 for 72 hours using a light source. The irradiated sample (control) was also irradiated, and after being kept constant at 25°C, the viscosity of both samples was The viscosity was measured using a B-type viscometer (BL type) (Model TV-10M, manufactured by Toki Sangyo Co., Ltd.) In Examples 1-3 to 1-4 and 1-4, an M4 rotor was used, and in the other examples, an M3 rotor was used. The measurement was carried out at 0°C and 6 rpm for 1 minute. The viscosity reduction rate was then calculated using the following formula. The results are shown in the same Table 5. <Viscosity reduction rate> Viscosity reduction rate (%) = (control sample viscosity - irradiated sample viscosity) / Troll sample viscosity x 100

[0133] Comparative Example 4-2 containing components (A) and (B) and Example 4 containing component (C) When comparing Examples 1-1 to 1-3, the addition of component (C) in each Example resulted in a decrease in the viscosity of Comparative Example 4- The viscosity reduction rate is smaller than that of 2, and the decrease in viscosity of the composition over time due to UV light is suppressed. It was shown that this would be the case.

[0134] In addition, when alginic acid was used instead of gellan gum as component (A) (Comparative Example 4 -3, 4 and Example 4-4), and when pectin was contained (Comparative Example 4-5 and Example 4-5 ) by adding component (C), the viscosity of the composition decreases over time due to ultraviolet light. It was shown that the lower

[0135] In all of Examples 4-1 to 4-5, the samples after storage had a good feel when used.

[0136] [Table 5]

[0137] [Formulation example] Based on the formulations in Tables 6 to 31 below, topical skin compositions of the present invention (Formulation Examples 1 to 26) were prepared. Made.

[0138] [Table 6]

[0139] [Table 7]

[0140] [Table 8]

[0141] [Table 9]

[0142] [Table 10]

[0143] [Table 11]

[0144]

Table 12

[0145]

Table 13

[0146]

Table 14

[0147]

Table 15

[0148] Table 16

[0149]

Table 17

[0150]

Table 18

[0151] Table 19

[0152] Table 20

[0153] Table 21

[0154] Table 22

[0155] Table 23

[0156] Table 24

[0157] Table 25

[0158] Table 26

[0159] Table 27

[0160] Table 28

[0161] Table 29

[0162] Table 30

[0163] Table 31

Claims

1. (A) a water-soluble polysaccharide, (B) nicotinamide at least 3% by mass, and (C) an amphiphilic component A composition for external use on the skin comprising:

2. The composition for external use on skin according to claim 1, wherein the content of the component (B) is 3 to 20% by mass. 。

3. The component (C) is a phosphorylcholine-containing polymer, a dicarboxylic acid ester, a carbon number 5 to 10 alkanediols and alkylene oxide derivatives represented by the following chemical formula (I): The composition for external use on skin according to claim 1 or 2, wherein the composition is one or more selected from the group consisting of thing: Z-{O(AO)a(EO)b-(BO)cH}n (I) (In the ceremony n is an integer from 1 to 9; Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms after removing n hydroxy groups. is a group obtained by removing AO is an oxyalkylene group having 3 to 4 carbon atoms; EO is an oxyethylene group; BO is an oxyalkylene group having 4 carbon atoms; a, b, and c are the average number of moles of AO, EO, and BO added, respectively; independently range from 0 to 200; a, b, and c cannot all be 0; AO and EO may be added randomly or in blocks; When n is 2 or more, the multiple a's, b's, and c's may be the same or different; When Z is a hydrogen atom, n is 1.

4. The component (A) may be a gum, a heparinoid, an alginic acid, agar, pectin, or pullulan.

4. The method according to claim 1, wherein the soluble fiber is one or more selected from the group consisting of orchids, mannans, and lactic acid bacteria. The composition for external use on skin described in any one of claims 1 to 4.

5. In the above chemical formula (I), Z is a hydrogen atom or an alkylmonoaromatic group having 4 to 24 carbon atoms. Alcohol, Glycerin, Trimethylolpropane, Erythritol, Pentaerythritol Alkyl glucoside, diglycerin, xylitol, dipentaerythritol, sol maltitol, inositol, sucrose, trehalose, maltitol or 1 to 10 carbon atoms A group obtained by removing n hydroxy groups from the hydroxy compound of 30. The composition for external use on skin according to claim 3 or 4.

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