Method for producing multi-component liquid composition preparation kit and jig used therefor

Abstract

To provide a method for producing a multi-component liquid composition preparation kit using a transport device equipped with a mechanical hand.SOLUTION: The method for manufacturing a multi-component liquid composition preparation kit utilizes a transport device equipped with a mechanical hand. The transport device is configured in that the mechanical hand can be switched between a gripping state in which it can grip a liquid agent packaging unit and a release state in which the gripping state is released, and can transport the liquid agent packaging unit using the mechanical hand in the gripping state. In the gripping state, the mechanical hand is configured in that it can grip the liquid agent packaging unit at the second ends of multiple liquid agent packages and press the liquid agent packaging unit in the stacking direction in the filling section of the multiple liquid agent packages. The transport device inserts the liquid agent packaging unit into an outer bag together with the mechanical hand in the gripping state.SELECTED DRAWING: Figure 20

Description

[Technical Field]

[0001] The present invention relates to a method for producing a kit for preparing a multi-component liquid composition such as a dental adhesive. [Background technology]

[0002] Dental materials such as composite resins and composite resin-type resin cements (hereinafter sometimes abbreviated as "CR, etc.") commonly used in dental treatment have almost no adhesive properties to tooth structure. Therefore, when performing treatment (tooth restoration), in order to firmly bond the hardened CR, etc. to the tooth structure, it is necessary to apply a dental adhesive (also called a bonding material) to the tooth surface using an applicator before filling or pressing the CR, etc.

[0003] Dental adhesives generally contain polymerizable monomers, including those with acidic groups, and a polymerization initiator for polymerizing and curing the polymerizable monomers. The polymerization initiator may be a chemical polymerization initiator that functions without light irradiation or heat. Because the chemical polymerization initiator contains a combination of multiple components, such as a reducing agent and an oxidizing agent, that react immediately upon contact, it must be stored in two or more separate liquid compositions. For this reason, dental adhesives using chemical polymerization initiators are typically stored as multiple liquid compositions, with the polymerizable monomer components appropriately divided according to the chemical polymerization initiator components, and these liquid compositions are mixed at the time of use to prepare the dental adhesive. Kits (in the present invention, a kit refers to a product that combines two or more agents into a single unit for the purposes of reducing the burden of preparation and preventing contamination and foreign matter) and jigs are also known to facilitate such storage, preparation, and application (using an applicator).

[0004] For example, Patent Documents 1 and 2 disclose kits for storing components of a multi-component liquid composition that exhibits a predetermined function as two or more liquid formulations, and for preparing the multi-component liquid composition by mixing the packaged liquid formulations at the time of use. This kit includes a composite liquid formulation package in which multiple liquid formulation storage sections are all connected together at a connecting section, and an outer bag that secures and airtightly houses the composite liquid formulation package. In this kit, the outer bag has a liquid reservoir space, and when a compressive force is applied to the liquid held in the liquid formulation storage section of the composite liquid formulation package secured and housed therein, causing the liquid formulation to flow out of one end of the liquid formulation storage section, all of the spilled liquid can be retained in the liquid reservoir space without coming into contact with the composite liquid formulation package.

[0005] Patent Document 2 also discloses a method for manufacturing a kit using a jig for positioning a composite liquid agent package in an appropriate position inside an outer bag with one end open before sealing. This jig includes a jig main body made of a block body having a flat bottom surface and a flat top surface arranged parallel to the bottom surface, with a bottomed groove having an opening formed in the top surface. The jig main body is formed so that the outer bag can be inserted and removed freely, and is configured so that the composite liquid agent package is positioned in an appropriate position inside the outer bag when the other end of the outer bag is inserted into the bottomed groove so as to abut against the groove bottom. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] International Publication No. 2020 / 158238 Brochure [Patent Document 2] Japanese Patent Publication No. 2023-091437 Summary of the Invention [Problem to be solved by the invention]

[0007] To reduce the manufacturing costs of such kits, it is effective to automate the process and reduce manual labor. However, the kits described above are inherently difficult to handle, as they are prone to defects such as leakage of the liquid agent from the liquid agent storage compartment due to pressure applied to the liquid agent storage compartment of the composite liquid agent package, or misalignment of the composite liquid agent package inside the outer bag. Therefore, an object of the present invention is to provide a method for manufacturing a multi-component liquid composition preparation kit using a conveying device equipped with a mechanical hand, and a jig for use therein. [Means for solving the problem]

[0008] In order to achieve the above object, a method for producing a multi-component liquid composition preparation kit according to one embodiment of the present invention utilizes a conveying device equipped with a mechanical hand. The manufacturing method includes: an outer pouch having a sealed first end, an open second end, and a container located between the first end and the second end; a liquid agent package unit including a plurality of liquid agent packages each including a heat-sealed third end and a fourth end, and a filling section located between the third end and the fourth end and filled with a liquid agent, the liquid agent packages being configured to be opened at the third end by pressing the filling section; and a joining section in which the plurality of liquid agent packages, each stacked with the fourth end and the filling section aligned, are joined by being further heat-sealed at the fourth end; The method includes a preparation step of preparing the above. The conveying device is configured such that the mechanical hand can be switched between a gripping state in which the liquid drug packaging unit is gripped and a release state in which the gripping state is released, and the liquid drug packaging unit can be conveyed by the mechanical hand in the gripping state. The mechanical hand has a pair of gripping portions that grip the joint portion of the liquid agent packaging unit in the gripping state, and a pair of extension portions that extend from the pair of gripping portions and press the liquid agent packaging unit from both sides in the stacking direction at the position of the filling portion of the multiple liquid agent packages in the gripping state. The manufacturing method further comprises: a conveying step of inserting the mechanical hand in the gripping state into the outer bag from the second end portion by the conveying device, and conveying the solution packaging unit so that the joint portion of the solution packaging unit overlaps with the second end portion of the outer bag, and the filling portion and the third end portion of the plurality of solution packages are positioned within the containing portion of the outer bag; a pulling-out process of switching the mechanical hand from the gripping state to the released state while maintaining the liquid agent packaging unit in the predetermined state by a jig, and pulling out the mechanical hand in the released state from inside the outer bag; and a sealing process for joining the second end of the outer bag and the joining portion of the liquid agent packaging unit by heat-sealing the second end of the outer bag while maintaining the liquid agent packaging unit in the predetermined state using the jig.

[0009] The pulling-out process may be performed in a state in which the liquid agent packaging unit and the outer bag in the predetermined state are pressed from both sides in the stacking direction at the position of the filling portion of the plurality of liquid agent packaging bodies by a pinching device for preventing misalignment.

[0010] The pinching device for preventing misalignment may have a pair of pressing surfaces formed with an uneven shape, and the pair of pressing surfaces may press the liquid agent packaging unit and the outer bag in the predetermined state from both sides in the stacking direction.

[0011] The pair of extension portions may include opposing surfaces that press the liquid agent packaging unit from both sides in the stacking direction in the gripped state, and an outward surface that faces opposite the opposing surfaces and includes an inclined portion that slopes toward the opposing surfaces toward the tip.

[0012] A jig according to one aspect of the present invention is used in the method for producing the multi-component liquid composition preparation kit to maintain the liquid agent package unit in the predetermined state. The jig has a first regulating surface that regulates the position of the tip of the first end of the outer bag, and a second regulating surface that regulates the position of the boundary area between the third end of the multiple liquid agent packages in the liquid agent packaging unit and the filling portion within the outer bag in which the position of the tip of the first end is regulated by the first regulating surface.

[0013] The jig may further include a slit portion having a closed end portion constituting the first restriction surface and an open end portion provided on the second restriction surface. The short-side dimension of the open end may be determined so that the third ends of the multiple liquid agent packages can enter the slit portion from the open end, and the boundary region of the liquid agent package unit cannot enter the slit portion from the open end. The depth dimension of the slit portion from the open end to the closed end may be equal to the distance between the tip of the first end of the outer bag and the boundary area of ​​the liquid agent packaging unit in the specified state.

[0014] The outer pouch may be configured as a pillow flat pouch with a back seal. The jig may further have a branched slit portion branching from the slit portion and accommodating the rear seal portion of the outer bag inserted into the slit portion. [Brief explanation of the drawings]

[0015] [Figure 1] 1 is a perspective view showing, from the front side, a multi-component liquid composition preparation kit manufactured by a manufacturing method according to one embodiment of the present invention. [Figure 2] FIG. 2 is a perspective view showing the multi-component liquid composition preparation kit from the rear side. [Figure 3] FIG. 2 is a perspective view showing a method of using the multi-component liquid composition preparation kit. [Figure 4] FIG. 2 is a perspective view showing a jig used in the manufacturing method from the front side. [Figure 5] FIG. 2 is a perspective view showing the jig from the rear side. [Figure 6] FIG. [Figure 7] 7 is a cross-sectional view of the jig taken along line AA' in FIG. 6. [Figure 8] 7 is a partial cross-sectional view of the jig taken along line BB' in FIG. 6. [Figure 9] FIG. 2 is a perspective view of an outer bag prepared in the above manufacturing method. [Figure 10] FIG. 2 is a perspective view of a liquid agent package unit prepared by the manufacturing method. [Figure 11] 11 is a cross-sectional view of the solution package unit taken along line CC' in FIG. 10. FIG. [Figure 12] FIG. 10 is a cross-sectional view showing a state in which an outer bag is inserted into the jig. [Figure 13] 13 is a diagram showing a state in which a liquid agent packaging unit is placed in the outer bag shown in FIG. 12. FIG. [Figure 14] FIG. 14 is a front view of the state shown in FIG. 13. [Figure 15] FIG. 10 is a block diagram showing the configuration of a conveying device that can be used in the manufacturing method. [Figure 16] 10A and 10B are diagrams illustrating a gripping state of a mechanical hand of the transport device. [Figure 17] FIG. 10 is a diagram showing the released state of the mechanical hand. [Figure 18] 3 is a flowchart showing the manufacturing method. [Figure 19] 3A to 3C are diagrams illustrating a transport step in the manufacturing method. [Figure 20] FIG. [Figure 21] 3A to 3C are diagrams illustrating a drawing step in the manufacturing method. [Figure 22] 10A to 10C are diagrams illustrating the above-mentioned drawing process. [Figure 23] FIG. 22 is a cross-sectional view taken along the line DD' in FIG. 21 in the drawing step. [Figure 24] 3A to 3C are diagrams illustrating a sealing step in the manufacturing method. [Figure 25] 3A to 3C are diagrams illustrating the sealing step. DETAILED DESCRIPTION OF THE INVENTION

[0016] [Introduction] Hereinafter, embodiments of the present invention will be described with reference to the drawings as appropriate. In this specification, unless otherwise specified, the expression "x to y" using numerical values ​​x and y means "greater than or equal to x and less than or equal to y." In such an expression, when a unit is assigned only to the numerical value y, the unit also applies to the numerical value x. Furthermore, in this specification, the term "(meth)acrylate" means both "acrylate" and "methacrylate," and the term "(meth)acryloyl" means both "acryloyl" and "methacryloyl."

[0017] [Kit 100 composition] A multi-component liquid composition preparation kit 100 manufactured by a manufacturing method according to one embodiment of the present invention will be described. In this specification, the "multi-component liquid composition preparation kit" will also be referred to simply as the "kit." In this specification, the direction in which the front of the kit 100 faces is referred to as the front, the direction in which the back of the kit 100 faces is referred to as the rear, and the up-down and left-right directions are based on the state in which the kit 100 is viewed from the front.

[0018] 1 and 2 are perspective views of kit 100, with Fig. 1 showing kit 100 from the front side and Fig. 2 showing kit 100 from the back side. Kit 100 includes an outer bag 110 and a liquid medication packaging unit 120. In kit 100, liquid medication packaging unit 120 is disposed inside outer bag 110. Note that Figs. 1 and 2 show the liquid medication packaging unit 120 in a state where the outer bag 110 is visible through it.

[0019] Outer bag 110 is configured as a flat bag (flat pillow bag) that is a pillow package formed into a rectangular shape from a film containing a thermoplastic resin. Outer bag 110 has a storage section 110a, a lower end section (first end section) 111 that forms the lower end section, an upper end section (second end section) 112 that forms the upper end section, and a rear seal section 113. Storage section 110a is located between lower end section 111 and upper end section 112, and forms an internal space of outer bag 110.

[0020] In outer bag 110, bottom end 111 and top end 112 face each other vertically with storage section 110a in between, and are heat-sealed across their entire range in the left-right direction. Back seal section 113 is a section where both ends are overlapped back to back and heat-sealed when the film constituting the pillow flat bag is formed into a cylindrical shape, and extends vertically in the left-right center of the back of outer bag 110. This seals the inside of storage section 110a in outer bag 110.

[0021] Additionally, outer bag 110 has a visible weakened line 114 in the upper right portion. Weakened line 114 extends diagonally downward to the right end from the tip of upper end portion 112. In outer bag 110, the strength of the portion along weakened line 114 is weakened so as to induce tearing along weakened line 114. With this configuration, outer bag 110 can be induced to tear along weakened line 114 when opened, and tearing of portions other than along weakened line 114 can be prevented.

[0022] Furthermore, a liquid reservoir 116 is provided in the storage section 110a of the outer bag 110. The liquid reservoir 116 constitutes an area on the lower end 111 side of the storage section 110a. Before use, the kit 100 has nothing placed in the liquid reservoir 116 of the outer bag 110. In the kit 100, the liquid reservoir 116 of the outer bag 110 is used as a space for mixing the multiple types of liquid agents stored in the liquid agent packaging unit 120 during use to prepare a multi-component liquid composition.

[0023] The solution packaging unit 120 has a plurality of solution packages 130. Each of the solution packages 130 is formed from a film containing a thermoplastic resin, and is configured as a pillow-like flat bag having a common rectangular shape. Each solution package 130 has a filling portion 130a, a lower end portion (third end portion) 131 that constitutes the lower end, and an upper end portion (fourth end portion) 132 that constitutes the upper end. The filling portion 130a is located between the lower end portion 131 and the upper end portion 132, and forms an internal space of the solution package 130.

[0024] In each solution package 130, the lower end 131 and the upper end 132 face each other in the vertical direction with the filling section 130a in between, and are heat-sealed over the entire range in the horizontal direction. This seals the filling section 130a in each solution package 130. In the solution package unit 120, the filling sections 130a of the multiple solution packages 130 are filled with different types of solution.

[0025] The different types of liquid agents filled in the filling sections 130a of the multiple liquid agent packages 130 are obtained by dividing the components of a multi-component liquid composition that exhibits a predetermined function into multiple components. A typical example of a multi-component liquid composition is a so-called two-component dental adhesive that contains, as its main components, polymerizable monomers including an acidic group-containing polymerizable monomer and a polymerizable monomer that does not have an acidic group, a chemical polymerization initiator, and a water-soluble organic solvent and / or water. Examples of components that are preferably used in two-component dental adhesives include the following:

[0026] Examples of the acidic group-containing polymerizable monomer include 2-(meth)acryloyloxyethyl dihydrogen phosphate, 10-(meth)acryloyloxydecyl dihydrogen phosphate, di[2-(meth)acryloyloxyethyl]hydrogen phosphate, di[10-(meth)acryloyloxydecyl]hydrogen phosphate, 4-(meth)acryloxyethyl trimellitic acid, 11-(meth)acryloyloxy-1,1-undecanedicarboxylic acid, and 1,4-di(meth)acryloyloxypyromellitic acid. Suitable compounds that can be used include those having at least one acidic group such as a phosphoric acid group, a carboxy group, a sulfonic acid group or a phosphonic acid group and at least one polymerizable unsaturated group in one molecule, such as methacryloyloxyethyl maleic acid, 2-(meth)acryloyloxyethyl phthalic acid, 2-(meth)acryloyloxyethylhexahydrophthalic acid, 2-methacrylamido-2-methylpropanesulfonic acid, 2-acrylamido-2-methylpropanesulfonic acid, p-vinylbenzenesulfonic acid and vinylsulfonic acid.

[0027] Examples of polymerizable monomers having no acidic group include 2-hydroxyethyl (meth)acrylate, 2-hydroxypropyl (meth)acrylate, glycerol di(meth)acrylate, 2,2'-bis{4-[3-(meth)acryloyloxy-2-hydroxypropoxy]phenyl}propane, 2,2'-bis[4-(meth)acryloyloxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxypolyethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydiethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxytetraethoxyphenyl]propane, 2,2'- Bis[4-(meth)acryloyloxypentaethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydipropoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxyethoxyethoxyphenyl]propane, 2-[4-(meth)acryloyloxydiethoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2-[4-(meth)acryloyloxydipropoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2,2-bis[4-(meth)acryloyloxypropoxyphenyl]propane, and the like can be suitably used.

[0028] Suitable water-soluble organic solvents include acetone, methanol, ethanol, n-propanol, isopropyl alcohol, and methyl ethyl ketone.

[0029] The chemical polymerization initiator may be a suitable combination of an oxidizing agent, a reducing agent, and a polymerization accelerator. Suitable oxidizing agents include organic peroxides such as benzoyl peroxide, parachlorobenzoyl peroxide, 2,4-dichlorobenzoyl peroxide, acetyl peroxide, lauroyl peroxide, tertiary butyl peroxide, cumene hydroperoxide, 2,5-dimethylhexane, 2,5-dihydroperoxide, methyl ethyl ketone peroxide, and tertiary butyl peroxybenzoate, and azo compounds such as azobisisobutyronitrile, methyl azobisisobutyrate, and azobiscyanovaleric acid. In addition, amine compounds such as N,N'-dimethyl-p-toluidine, N,N'-dimethylaniline, N'-β-hydroxyethyl-aniline, N,N'-di(β-hydroxyethyl)-aniline, N,N'-di(β-hydroxyethyl)-p-toluidine, N-methyl-aniline, and N-methyl-p-toluidine are preferably used as reducing agents. Furthermore, vanadium compounds, copper compounds, sulfinates, borate compounds, thiourea compounds, and the like are preferably used as polymerization accelerators. Note that each chemical polymerization initiator system is designed to function as an initiator when all components are present, and the combination of components when packaged is appropriately determined taking into account storage stability depending on the type of liquid formulation and the specific compounds used. For example, borate, which is classified as a polymerization accelerator above, can also function as a reducing agent under certain conditions, but it can also be stored in the presence of an oxidizing agent in the absence of an acidic compound (unless under acidic conditions).

[0030] In the solution packaging unit 120, a plurality of solution packages 130 are stacked with their upper end portions 132 and filling portions 130a aligned. The solution packaging unit 120 is provided with a joining portion 121 that joins the plurality of solution packages 130 at their upper end portions 132. The joining portion 121 is formed by further heat-sealing the upper end portions 132 of the plurality of stacked solution packages 130.

[0031] Each of the liquid agent packages 130 constituting the liquid agent package unit 120 is configured so that the lower end portion 131 selectively breaks when the liquid pressure of the liquid agent in the filling portion 130a increases. Therefore, in the liquid agent package unit 120, by pressing the multiple liquid agent packages 130 at the position of the filling portion 130a from both sides in the stacking direction, all of the liquid agent packages 130 can be opened at the lower end portion 131 all at once.

[0032] The dimensions of the liquid agent packaging unit 120 are smaller than those of the outer bag 110 in both the left-right and up-down directions. The liquid agent packaging unit 120 is located in the upper left part of the outer bag 110. In other words, the liquid agent packaging unit 120 is located inside the outer bag 110, in an area to the left of the weakening line 114 and above the liquid reservoir 116 so as not to overlap with the weakening line 114 and the liquid reservoir 116.

[0033] The sizes of the outer bag 110 and the liquid agent packaging unit 120 constituting the kit 100 can be determined appropriately depending on the intended use, etc. For example, the size of the outer bag 110 can be determined depending on the size of each liquid agent packaging 130, the amount of the multi-component liquid composition to be prepared, etc. Furthermore, the size of each liquid agent packaging 130 constituting the liquid agent packaging unit 120 can be determined depending on the amount of liquid agent to be filled in the filling section 130a, etc.

[0034] For example, if the multi-component liquid composition is a dental adhesive, kit 100 is expected to be used only once and then discarded. In this case, the amount of liquid filled in filling section 130a of each liquid agent package 130 is typically about 0.03 to 0.1 ml, and the vertical dimensions are about 16 to 40 mm and the horizontal dimensions are about 5 to 15 mm. Furthermore, outer bag 110 has a vertical dimension of about 28 to 72 mm and a horizontal dimension of about 12 to 36 mm.

[0035] In the solution packaging unit 120, the joint portion 121 is sandwiched between two films that form the upper end portion 112 of the outer bag 110, and the filling portion 130a and the lower end portion 131 are located within the storage portion 110a of the outer bag 110. In the kit 100, when the upper end portion 112 of the outer bag 110 is heat-sealed, the upper end portion 112 of the outer bag 110 and the joint portion 121 of the solution packaging unit 120 are joined together, thereby integrating the outer bag 110 and the solution packaging unit 120.

[0036] In the kit 100, a pressure mark 115 is provided on the outer bag 110 at a position that overlaps with the center of the filling portion 130a of the multiple liquid agent packages 130. The pressure mark 115 is provided on each of the front and back surfaces of the outer bag 110. In the kit 100, the pressure mark 115 on the outer bag 110 allows the user to recognize the correct pressing position. The pressure mark 115 can be provided on the front and back surfaces of the outer bag 110 by printing, for example.

[0037] [How to use Kit 100] A method of using the kit 100 will now be described. FIG. 3 is a perspective view showing a method of using the kit 100. When using the kit 100, an applicator 140 is used. The applicator 140 is in the shape of a long, thin rod, and has a liquid holding portion 141 at its tip. The applicator 140 can hold the liquid in the liquid holding portion 141 by immersing the liquid holding portion 141 in the liquid. The liquid holding portion 141 can be configured as, for example, a brush that can hold the liquid between fibers. Note that the applicator 140 is not limited to the above configuration as long as it has a liquid holding portion 141 configured to have the function of holding the liquid. Furthermore, the applicator 140 does not have to be included in the kit 100, and may be prepared separately from the kit 100.

[0038] When using the kit 100, first, the kit 100 is pinched with two fingers at the pressure marks 115 on the front and back of the outer bag 110, and the filling sections 130a of the multiple liquid agent packages 130 are pressed from outside the outer bag 110. This causes the bottom end 131 of each liquid agent package 130 to break, and the liquid agent in the filling section 130a flows from the bottom end 131 into the liquid reservoir 116 of the outer bag 110. As a result, in the kit 100, the multiple types of liquid agent flowing out from the multiple liquid agent packages 130 are mixed in the liquid reservoir 116 of the outer bag 110, thereby preparing a multi-component liquid composition. Note that the operation of pressing the filling sections 130a of the multiple liquid agent packages 130 from outside the outer bag 110 does not necessarily have to be performed by pinching with two fingers, and can also be performed using, for example, an auxiliary tool for pressing.

[0039] Next, outer pouch 110 is opened by tearing it along weakened line 114. Next, while holding opened outer pouch 110 in one hand and applicator 140 in the other hand, liquid holding portion 141 of applicator 140 is inserted from the opening in outer pouch 110 along weakened line 114 and immersed in the multi-component liquid composition in liquid reservoir 116, thereby causing the multi-component liquid composition to be held in liquid holding portion 141. Then, the mixed medicine held in liquid holding portion 141 of applicator 140 is applied to the target site.

[0040] [Jig 200] The jig 200 used in the manufacturing method of the kit 100 according to this embodiment will now be described. Figures 4 to 6 are views showing the jig 200, with Figure 4 being a perspective view of the jig 200 shown from the front side, Figure 5 being a perspective view of the jig 200 shown from the rear side, and Figure 6 being a top view of the jig 200. The jig 200 is configured as a resin block body, and has a bottom surface 201 and a top surface 202 which are flat surfaces parallel to each other.

[0041] Examples of resins that can be used to form the jig 200 include polyethylene (PE), polypropylene (PP), polyoxymethylene (POM), polybutadiene terephthalate (PBT), acrylonitrile-butadiene-styrene copolymer synthetic resin (ABS resin), polyamide (PA), polymethyl methacrylate (PMMA), and polytetrafluoroethylene (PTFE). The jig 200 can be formed, for example, using a 3D printer or by cutting. Alternatively, the jig 200 can be produced by molding a block body into several parts (divided so that the final form can be easily assembled) and assembling them.

[0042] 4 to 6 is provided with five slit portions 210. In the jig 200, each slit portion 210 can be used to manufacture one kit 100, that is, the configuration shown in Figures 4 to 6 allows five kits 100 to be manufactured simultaneously. It is sufficient that the jig 200 is provided with at least one slit portion 210, that is, the number of slit portions 210 may be four or less, or six or more.

[0043] 7 and 8 show a cross section of the jig 200, with Fig. 7 being a cross section of the jig 200 taken along line A-A' in Fig. 6, and Fig. 8 being a partial cross section of the jig 200 taken along line B-B' in Fig. 6. Note that Figs. 7 and 8 show a simplified view of the configuration of the jig 200 by appropriately omitting components other than the slit portion 210. Also, Fig. 8 shows a partial cross section of one slit portion 210 in the jig 200. In a jig 200 provided with a plurality of slit portions 210, all of the plurality of slit portions 210 have the same configuration.

[0044] In the jig 200, the slit portion 210 has a closed end 211 and an open end 212, and extends in the vertical direction between the closed end 211 and the open end 212. The closed end 211 is provided above the bottom surface 201 with a gap therebetween and is closed from below. The open end 212 is provided on the top surface 202 and is open upward. In the jig 200, the closed end 211 of the slit portion 210 is configured as a surface at a certain depth from the top surface 202 of the jig 200.

[0045] 4 to 6, the jig 200 is provided with branched slit sections 220 that branch off from the center of each slit section 210 toward the back side. In the jig 200, the branched slit sections 220 extend downward from the upper surface 202 to the same depth as the closed ends 211 of the slit sections 210. In the jig 200, the back seal sections 113 of the outer bag 110 that are inserted into each slit section 210 are housed.

[0046] In kit 100, it is necessary to print a lot number, expiration date, etc. visibly on outer bag 110. In response to this, jig 200 is provided with openings 230 that penetrate from the back surface to each slit section 210, as shown in Fig. 5. This allows jig 200 to print, using a method such as laser printing, in the area within opening 230 on the back surface of outer bag 110 when outer bag 110 is inserted into each slit section 210.

[0047] 9 to 11 show an outer bag 110 and a solution packaging unit 120 prepared in a preparation step S01, which will be described later, in the manufacturing method of the kit 100 according to this embodiment, with Fig. 9 being a perspective view of the outer bag 110, Fig. 10 being a perspective view of the solution packaging unit 120, and Fig. 11 being a cross-sectional view of the solution packaging unit 120 taken along line CC' in Fig. 10. The outer bag 110 shown in Fig. 9 is in a state before the upper end portion 112 is sealed during the manufacturing process of the kit 100. The solution packaging unit 120 shown in Figs. 10 and 11 is in a state before being housed in the outer bag 110 during the manufacturing process of the kit 100.

[0048] 11, the boundary region P of the solution packaging unit 120 is shown as an area surrounded by a dashed line. The boundary region P of the solution packaging unit 120 is an area where the boundaries between the lower end portions 131 of the plurality of solution packages 130 and the filling portions 130a overlap. The boundary region P of the solution packaging unit 120 includes adjacent portions of the lower end portions 131 and the filling portions 130a of the plurality of solution packages 130, that is, includes the lower portion of the filling portion 130a (the end portion whose width narrows toward the lower end portion 131).

[0049] Here, the state in which the vertical position of the solution packaging unit 120 in the outer bag 110 matches that of the finished kit 100 is referred to as a "predetermined state." The jig 200 is configured to regulate the relative vertical positions of the outer bag 110 and the solution packaging unit 130, thereby enabling the solution packaging unit 120 to be maintained in a predetermined state within the outer bag 110. Specifically, in the jig 200, the closed end 211 of the slit portion 210 is configured as a first regulating surface that regulates the tip of the lower end 131 of the outer bag 110, and the upper surface 202 on which the open end 212 of the slit portion 210 is provided is configured as a second regulating surface that regulates the boundary region P of the solution packaging unit 120.

[0050] 7 and 8 show the longitudinal (left-right) dimension L and the lateral (front-rear) dimension W of the open end 212 of the slit section 210 of the jig 200. Also shown in Figures 7 and 8 is the depth (up-down) dimension D of the slit section 210 of the jig 200. In the jig 200, it is preferable that the longitudinal dimension L of the open end 212 of the slit section 210 is slightly larger than the lateral dimension of the outer bag 110. Furthermore, in the jig 200, the lateral dimension W of the open end 212 of the slit section 210 and the depth dimension D of the slit section 210 are determined so that the outer bag 110 and the solution package 130 can be positioned relative to each other in the up-down direction.

[0051] Specifically, the dimension W in the short side direction of the open end 212 of the slit section 210 is determined so that the lower end portions 131 of the multiple solution packages 130 constituting the solution packaging unit 120 can enter the slit section 210 from the open end 212, but the boundary region P of the solution packaging unit 120 cannot enter the slit section 210 from the open end 212. Furthermore, the dimension D in the depth direction of the slit section 210 is determined so as to be equivalent to the distance between the tip of the lower end portion 111 of the outer bag 110 and the boundary region P of the solution packaging unit 120 in a predetermined state.

[0052] 12, in the jig 200, the outer bag 110 is first inserted into the slit portion 210 from the open end 212, and the tip of the lower end portion 111 of the outer bag 110 is abutted against the closed end portion 211 of the slit portion 210. At this time, the rear seal portion 113 of the outer bag 110 is accommodated in the branching slit portion 220 of the jig 200. With the outer bag 110 set in the jig 200 as shown in FIG. 12, the upper end portion 112 is more likely to be opened widely because the rear seal portion 113 is accommodated in the branching slit portion 220.

[0053] 13 and 14 show a state in which the solution packaging unit 120 is disposed in the outer bag 110 inserted into the slit portion 210. In the solution packaging unit 120 in the state shown in Figures 13 and 14, the lower end portions 131 of the multiple solution packages 130 enter the slit portion 210 from the open end 212, and the boundary region P of the solution packaging unit 120 cannot enter the slit portion 210 from the open end 212 and remains on the upper surface 202.

[0054] 13 and 14 , the tip of the lower end 111 of the outer bag 110 is restricted by the closed end 211 of the slit portion 210, and the boundary region P of the solution packaging unit 120 is restricted by the upper surface 202 within the outer bag 110, so that the solution packaging unit 120 is in a predetermined state within the outer bag 110. In this manner, with the jig 200, the solution packaging unit 120 can be brought into a predetermined state within the outer bag 110 simply by setting the outer bag 110 and the solution packaging unit 120 in the jig 200 in this order.

[0055] In the liquid agent packaging unit 120, the shape of the filling section 130a filled with the liquid agent in each liquid agent packaging 130 may be deformed, resulting in slight individual differences in the dimensions of the boundary region P. Therefore, when the outer bag 110 and the liquid agent packaging unit 120 are set in the jig 200, the lower portions of the multiple filling sections 130a that constitute the boundary region P of the liquid agent packaging unit 120 may partially enter the open end 212 of the slit section 210.

[0056] For this reason, in the solution packaging unit 120 maintained in a predetermined state by the jig 200, slight vertical positional deviation occurs relative to the outer bag 110 depending on the degree to which the lower parts of the multiple filling sections 130a constituting the boundary region P enter the slit section 210. However, in the jig 200, such positional deviation can be kept within an allowable range by adjusting the dimension W in the short direction of the open end 212 of the slit section 210.

[0057] [Transportation device 300] A transfer device 300 used in the manufacturing method according to this embodiment will be described. Fig. 15 is a block diagram showing the configuration of the transfer device 300. The transfer device 300 has a mechanical hand 310, a mechanical arm 320, a control unit 330, and a memory unit 340. In the transfer device 300, the mechanical hand 310 is attached to the tip of the mechanical arm 320, and the mechanical hand 310, the mechanical arm 320, and the memory unit 340 are all connected to the control unit 330.

[0058] The mechanical hand 310 is configured to be able to grip the solution packaging unit 120. The mechanical arm 320 is configured to be able to change the position and posture of the mechanical hand 310 gripping the solution packaging unit 120. The control unit 330 is configured to be able to control the operation of the transport device 300 including the mechanical hand 310 and the mechanical arm 320. The memory unit 340 stores information required to operate the transport device 300, such as a control program for the control unit 330 and the control details of the mechanical hand 310 and the mechanical arm 320 by the control unit 330.

[0059] 16 and 17 show a mechanical hand 310. The mechanical hand 310 has a pair of gripping portions 311 and a pair of extending portions 312. The pair of gripping portions 311 and the pair of extending portions 312 are typically formed of a metal material. The pair of gripping portions 311 have a pair of opposing surfaces 311a that face each other. The pair of extending portions 312 are each formed integrally with the pair of gripping portions 311, and extend downward from outer positions opposite the opposing direction of the pair of opposing surfaces 311a of the pair of gripping portions 311.

[0060] The pair of extending portions 312 have a pair of opposing surfaces 312a that face each other, and a pair of outward surfaces 312b that face the opposite side of the pair of opposing surfaces 312a. In each extending portion 312, the opposing surfaces 312a are configured as flat surfaces, and each outward surface 312b includes an inclined portion Q that slopes toward the opposing surfaces 312a toward the tip of the extending portion 312. In each extending portion 312, the inclined portion Q is preferably rounded.

[0061] The conveying device 300 can switch the mechanical hand 310 between a gripping state in which the solution packaging unit 120 is gripped and a release state in which the gripping state releases the solution packaging unit 120. Fig. 16 shows the gripping state of the mechanical hand 310, and Fig. 17 shows the release state of the mechanical hand 310. In the gripping state of the mechanical hand 310, the pair of gripping portions 311 and the pair of extension portions 312 are closed, and in the release state, the pair of gripping portions 311 and the pair of extension portions 312 are open.

[0062] 16, the mechanical hand 310 firmly holds the joint 121 of the solution packaging unit 120 between a pair of opposing surfaces 311a of the pair of gripping portions 311. As a result, in the transport device 300, the mechanical arm 320 moves the mechanical hand 310 in the gripping state, thereby making it possible to transport the solution packaging unit 120 gripped by the mechanical hand 310.

[0063] Furthermore, the mechanical hand 310 in the gripping state presses the solution packaging unit 120 from both sides in the stacking direction to prevent the plurality of solution packages 130 from spreading in the stacking direction, using the pair of opposing surfaces 312a of the pair of extension portions 312. In other words, the pair of extension portions 312 presses the solution packaging unit 120 at the positions of the filling portions 130a of the plurality of solution packages 130 with a force weak enough not to break the lower end portions 131 of the plurality of solution packages 130.

[0064] 17, the facing surfaces 311a of the pair of gripping portions 311 are spaced apart from the connecting portions 121 of the solution packaging unit 120, and the facing surfaces 312a of the pair of extending portions 312 are spaced apart from the filling portions 130a of the plurality of solution packages 130. Therefore, the transport device 300 can move the mechanical hand 310 in the released state while keeping the solution packaging unit 120 in a predetermined state.

[0065] [Kit 100 manufacturing method] A method for manufacturing the kit 100 according to this embodiment will be described. FIG. 18 is a flowchart showing a method for manufacturing the kit 100. The method for manufacturing the kit 100 includes a preparation step S01, an outer bag setting step S02, a conveying step S03, a pulling-out step S04, and a sealing step S05. In the preparation step S01, an outer bag 110 having an unsealed upper end 112 shown in FIG. 9 and a solution packaging unit 120 shown in FIGS. 10 and 11 are prepared. In the outer bag setting step S02, the outer bag 110 is set in a slit portion 210 of a jig 200, as shown in FIG. 12.

[0066] 19 and 20 show the conveying step S03. In the conveying step S03, the conveying device 300 conveys the solution packaging unit 120 by moving the mechanical hand 310 in a gripping state using the mechanical arm 320. In the conveying step S03, first, as shown in FIG. 19 , the solution packaging unit 120 is positioned above the open upper end 112 of the outer bag 110 set in the slit portion 210 of the jig 200. Then, as shown in FIG. 20 , the solution packaging unit 120 together with the gripping mechanical hand 310 is inserted into the outer bag 110 from the upper end 112, and the solution packaging unit 120 is arranged in a predetermined state within the outer bag 110.

[0067] In the conveying device 300, the solution packaging unit 120 is placed in the outer bag 110 while being pressed from both sides in the stacking direction by the pair of extending portions 312, which makes it less likely that friction will occur due to contact between the resins of the outer bag 110 and the solution packaging unit 120. Furthermore, in the mechanical hand 310, an inclined portion Q is provided on each outward surface 312b of each extending portion 312, so that each extending portion 312 is less likely to get caught on the upper end portion 112 of the outer bag 110 when inserted into the outer bag 110. As a result, the conveying device 300 can smoothly place the solution packaging unit 120 in the outer bag 110.

[0068] 21 and 22 show the pulling-out step S04. In the pulling-out step S04, a pinching device 400 for preventing displacement, which has a pair of opposing pressing portions 410, is used. In the pulling-out step S04, first, as shown in FIG. 21 , the pair of pressing portions 410 of the pinching device 400 for preventing displacement lightly pinch and press the solution packaging unit 120 in a predetermined state from both sides in the stacking direction. That is, the pair of pressing portions 410 of the pinching device 400 for preventing displacement press the solution packaging unit 120 from the outside of the outer bag 110 at the position of the filling portions 130a of the plurality of solution packages 130 with a force weak enough not to rupture the lower end portions 131 of the plurality of solution packages 130.

[0069] 22 , while the pair of pressing parts 410 of the pinching device 400 for preventing displacement presses the solution packaging unit 120 in a predetermined state, the mechanical hand 310 is switched from the gripping state to the release state, and only the mechanical hand 310 is pulled out from the outer bag 110. Thereafter, the pinching device 400 for preventing displacement separates the pair of pressing parts 410 from the outer bag 110, and releases the pressure on the solution packaging unit 120 by the pair of pressing parts 410.

[0070] In the pulling-out step S04, the pinching device 400 for preventing misalignment presses the solution packaging unit 120 in a predetermined state from the outside of the outer bag 110, so that the positions of the outer bag 110 and the solution packaging unit 120 are unlikely to change even when the mechanical hand 310 comes into contact with the outer bag 110 or the solution packaging unit 120. Therefore, in the pulling-out step S04, the positions of the outer bag 110 and the solution packaging unit 120 are unlikely to shift when the mechanical hand 310 is switched from the gripping state to the release state or when the mechanical hand 310 is pulled out of the outer bag 110.

[0071] Fig. 23 is a cross-sectional view taken along line DD' in Fig. 21, showing a preferred form of the pair of pressing portions 410 of the pinching device 400 for preventing displacement. Fig. 23 shows the state before the pair of pressing portions 410 press the solution packaging unit 120. The pair of pressing portions 410 are each configured as a plate-like member that is thin in the vertical direction and extends in the horizontal direction, and have a pair of pressing surfaces 411 that face each other in the front-to-rear direction. In the pinching device 400 for preventing displacement, the pair of pressing surfaces 411 are brought into contact with the outer bag 110 when pressing the solution packaging unit 120.

[0072] In the pair of pressing sections 410, the pair of pressing surfaces 411 are configured as uneven surfaces having an uneven shape formed in the front-rear direction that continues along the left-right direction. In the pinching device for preventing displacement 400, the pair of pressing surfaces 411 are uneven surfaces and the number of contact points with the outer bag 110 is reduced, making it possible to firmly press the liquid agent packaging unit 120 with a weak force that is not enough to break the lower end portions 131 due to the pressure applied to the filling portions 130a of the multiple liquid agent packages 130.

[0073] Furthermore, each of the pair of pressing surfaces 411 of the pair of pressing parts 410 is provided with a notch 412 that is largely recessed outward at a position where the liquid agent packaging unit 120 is pressed. This makes it possible for the pinching device 400 to prevent contact between the extension part 312 and the pinching device 400 for preventing displacement when the mechanical hand 310 is switched to the release state or when the mechanical hand 310 is pulled out from the outer bag 110. Furthermore, the action of the notch 412 also makes it possible to release pressure applied from the pair of pressing surfaces 411 to the filling parts 130a of the plurality of liquid agent packages 130 to the notch 412. This makes it possible for the pinching device 400 for preventing displacement to more effectively prevent large pressure from being applied to the filling parts 130a of the plurality of liquid agent packages 130.

[0074] 24 and 25 show the sealing step S05. In the sealing step S05, a heat-sealing device 500 having a pair of heaters 510 is used. In the sealing step S05, first, as shown in Fig. 24, the pair of heaters 510 of the heat-sealing device 500 are set on both sides of the upper end portion 112 of the outer bag 110 and the joint portion 121 of the solution packaging unit 120. Then, the upper end portion 112 of the outer bag 110 is sandwiched between the pair of heaters 510 and heat-sealed, thereby joining the upper end portion 112 of the outer bag 110 and the joint portion 121 of the solution packaging unit 120.

[0075] 1 and 2 is completed by the sealing step S05, as shown in Fig. 25. When a jig 200 having a plurality of slits 210 is used in the sealing step S05, it is preferable to use a heat-sealing device 500 having a pair of heaters 510 that are long in the left-right direction and can collectively heat-seal the upper ends 112 of a plurality of outer bags 110 inserted into the plurality of slits 210 of the jig 200. In this way, a plurality of kits 100 can be obtained simultaneously by the sealing step S05.

[0076] [Other embodiments] Although the embodiments of the present invention have been described above, it goes without saying that the present invention is not limited to the above-described embodiments and that various modifications can be made.

[0077] For example, in the drawings used in the above description, an example is shown in which the liquid drug packaging unit 120 comprises two liquid drug packages 130, i.e., the components of the multi-component liquid composition are separated into two types of liquid drug and packaged in two liquid drug packages 130. However, the kit 100 may also be configured such that the liquid drug packaging unit 120 comprises three or more liquid drug packages 130, i.e., the components of the multi-component liquid composition are separated into three or more types of liquid drug and packaged in three or more liquid drug packages 130.

[0078] Furthermore, in the manufacturing method of the kit 100 according to the present embodiment, the configuration of the pinching device 400 for preventing displacement used in the pulling-out step S04 is not limited to that described above, and for example, the configuration of the pressing surface 411 of the pressing portion 410 may be different from that described above. Furthermore, in the pulling-out step S04, if displacement of the liquid agent packaging unit 120 from the predetermined state can be prevented by another method, it is not necessarily necessary to use the pinching device 400 for preventing displacement.

[0079] Furthermore, in the manufacturing method of the kit 100 according to this embodiment, the configuration of the mechanical hand 310 of the conveying device 300 used in the conveying step S03 is not limited to the above; for example, the configuration of at least one of the gripping portion 311 and the extending portion 312 may be different from that described above. The mechanical hand 310 according to this embodiment also includes various configurations that can mechanically realize the above functions, and in particular includes a robot hand capable of teaching. Furthermore, the conveying device 300 only needs to be equipped with the mechanical hand 310, and other configurations can be modified or added as appropriate.

[0080] Additionally, in the manufacturing method of the kit 100 according to this embodiment, the configuration of the jig 200 is not limited to the above, as long as the jig 200 is configured to be able to maintain the solution packaging unit 120 in a predetermined state within the outer bag 110. For example, the configuration of the slit portion 210 in the jig 200 may be different from that described above, and at least one of the branched slit portion 220 and the opening 230 may not be provided. Furthermore, in the jig 200 provided with a plurality of slit portions 210, the arrangement of the plurality of slit portions 210 can be changed as appropriate.

[0081] Furthermore, the jig 200 is not limited to a configuration in which the left-right dimension of the slit portion 210 is a constant dimension L from the open end 212 throughout the depth direction, and the front-rear dimension of the slit portion 210 is a constant dimension W throughout the depth direction from the open end 212. For example, the slit portion 210 of the jig 200 may have at least one of the left-right dimension and the front-rear dimension changing from the open end 212 toward the closed end 211.

[0082] Furthermore, in a configuration in which a plurality of kits 100 can be simultaneously manufactured, the jig 200 may be configured such that the above-mentioned plurality of slit portions 210 are connected in the left-right direction to form a series of slit portions 210 corresponding to the plurality of kits 100. In addition, in the jig 200, the slit portions 210 may penetrate in the up-down direction, and the closed ends 211 of the slit portions 210 may be formed by blocking the slit portions 210 from below with a flat surface on which the jig 200 is placed.

[0083] In addition, the kit 100 manufactured by the manufacturing method according to this embodiment is not limited to the above configuration. For example, in the kit 100, the left-right position of the solution packaging unit 120 in the outer pouch 110 can be changed as appropriate. In addition, in the kit 100, the outer pouch 110 and the solution packaging 130 may be configured as a bag body with a configuration other than a pillow-like flat pouch. Furthermore, the kit 100 may be configured without at least one of the weakened line 114 and the pressure mark 115. [Explanation of symbols]

[0084] 100...Multi-component liquid composition preparation kit 110...Outer bag 110a...Storage section 111...Lower end 112...Top end 113...Rear seal 120...Liquid drug packaging unit 121...Joining part 130...Liquid drug packaging body 130a...Filling section 131...Lower end 132...Top end 200...jig 201...Bottom 202…Top surface 210...Slit section 211...Closed end 212...Open end 220...Branched slit section 300...Transportation device 310...Mechanical Hand 311...Gripping part 311a...Opposing surface 312...Extending part 312a...Opposing surface 312b…extroverted surface 400...Pinching device to prevent misalignment 410...Pressing part 411...Pressing surface

Claims

1. A method for producing a multi-component liquid composition preparation kit using a conveying device equipped with a mechanical hand, comprising: The manufacturing method includes: an outer pouch having a sealed first end, an open second end, and a container located between the first end and the second end; a liquid agent package unit including a plurality of liquid agent packages each including a heat-sealed third end and a fourth end, and a filling section located between the third end and the fourth end and filled with a liquid agent, the liquid agent packages being configured to be opened at the third end by pressing the filling section; and a joining section in which the plurality of liquid agent packages, each stacked with the fourth end and the filling section aligned, are joined by being further heat-sealed at the fourth end; a preparation step of preparing the conveying device is configured to switch the mechanical hand between a gripping state in which the liquid agent packaging unit is gripped and a release state in which the gripping state is released, and to convey the liquid agent packaging unit by the mechanical hand in the gripping state, the mechanical hand has a pair of gripping portions that grip the joint portion of the liquid agent packaging unit in the gripping state, and a pair of extension portions that extend from the pair of gripping portions and press the liquid agent packaging unit from both sides in the stacking direction at the positions of the filling portions of the plurality of liquid agent packages in the gripping state, The manufacturing method further comprises: a conveying step of inserting the mechanical hand in the gripping state into the outer bag from the second end by the conveying device, and conveying the solution packaging unit so that the joint portion of the solution packaging unit overlaps with the second end of the outer bag and the filling portion and the third end of the plurality of solution packages are positioned within the containing portion of the outer bag; a pulling-out process of switching the mechanical hand from the gripping state to the released state while maintaining the liquid agent packaging unit in the predetermined state by a jig, and pulling out the mechanical hand in the released state from inside the outer bag; a sealing step of heat-sealing the second end of the outer bag while maintaining the liquid agent packaging unit in the predetermined state by the jig, thereby joining the second end of the outer bag and the joining portion of the liquid agent packaging unit. A method for producing a multi-component liquid composition preparation kit.

2. A method for producing the multi-component liquid composition preparation kit according to claim 1, comprising: The pulling-out step is performed while the liquid agent package unit and the outer bag in the predetermined state are pressed from both sides in the stacking direction at the position of the filling portion of the plurality of liquid agent packages by a pinching device for preventing misalignment. A method for producing a multi-component liquid composition preparation kit.

3. A method for producing the multi-component liquid composition preparation kit according to claim 2, comprising: The pinching device for preventing displacement has a pair of pressing surfaces formed with an uneven shape, and the pair of pressing surfaces press the liquid agent packaging unit and the outer bag in the predetermined state from both sides in the stacking direction. A method for producing a multi-component liquid composition preparation kit.

4. A method for producing the multi-component liquid composition preparation kit according to any one of claims 1 to 3, comprising: The pair of extension portions include opposing surfaces that press the solution package unit from both sides in the stacking direction in the gripped state, and outward surfaces that face the side opposite to the opposing surfaces and include inclined portions that are inclined toward the opposing surfaces toward their tips. A method for producing a multi-component liquid composition preparation kit.

5. 4. A jig for maintaining the liquid agent package unit in the predetermined state in the method for producing the multi-component liquid composition preparation kit according to claim 1, The jig has a first restricting surface that restricts the position of the tip of the first end of the outer bag, and a second restricting surface that restricts the position of a boundary region between the third end of the plurality of solution packages in the solution package unit and the filling portion within the outer bag in which the position of the tip of the first end is restricted by the first restricting surface. jig.

6. The jig according to claim 5, the jig further includes a slit portion having a closed end portion constituting the first restriction surface and an open end portion provided on the second restriction surface, a dimension in the short side direction of the open end portion is determined such that the third ends of the plurality of liquid agent packages can enter the slit portion from the open end portion, and the boundary region of the liquid agent package unit cannot enter the slit portion from the open end portion; a dimension in a depth direction from the open end to the closed end of the slit portion is equal to the distance between the tip of the first end of the outer bag and the boundary region of the liquid agent package unit in the predetermined state; jig.

7. The jig according to claim 6, The outer bag is configured as a pillow flat bag having a back seal portion, The jig further includes a branched slit portion that branches off from the slit portion and receives the rear seal portion of the outer bag inserted into the slit portion. jig.

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