Oral composition for hair growth

Abstract

To provide an oral composition exhibiting superior hair growth effect.SOLUTION: An oral composition for hair growth comprising corosolic acid and polyamine.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a composition having a hair growth effect, which contains corosolic acid and a polyamine. [Background technology]

[0002] Eyelashes are an important part of the face that affect the overall impression, and mascara, false eyelashes, and eyelash extensions are commonly used to make eyelashes stand out. However, these are merely decorative eyelashes and do not actually lengthen the eyelashes themselves.

[0003] One method for lengthening eyelashes is to use eyelash serums. Patent Document 1 describes a method for lengthening eyelashes, characterized by locally applying a composition containing creatine or the like to the eyelashes or their roots. However, locally applying a serum to the eyelashes or the like is time-consuming and there is a risk that the serum may adhere to the eyes or damage the cornea during application. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication No. 2011 / 056330 Brochure Summary of the Invention [Problem to be solved by the invention]

[0005] For these reasons, a simpler method for lengthening eyelashes is desired. [Means for solving the problem]

[0006] The present invention includes, for example, the following aspects.

[0007] [1] An oral composition for hair growth containing corosolic acid and a polyamine. [2] An oral composition for hair growth containing loquat leaf extract and rice germ extract. [3] The oral composition for hair growth according to [2] above, further comprising a pea sprout extract. [4] The oral composition for hair growth according to [3] above, which contains loquat leaf extract, rice germ extract, and pea sprout extract in a ratio of 1:1-5:0.3-1. [5] The oral composition for hair growth according to [1] or [2] above, which is for growing eyelashes. [6] The oral composition for hair growth according to [1] or [2], further comprising one or more selected from biotin, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin E, and zinc compounds. [7] A capsule containing the oral composition for hair growth according to any one of [1] to [6] above. [8] The oral composition for hair growth according to any one of [1] to [6] above, which is in the form of granules or tablets. [Effects of the Invention]

[0008] According to the present invention, eyelashes can be lengthened in a simple manner by ingesting the oral composition for hair growth of the present invention. [Brief explanation of the drawings]

[0009] [Figure 1] This is a graph showing the average length of left and right eyelashes before intake, after two weeks of intake, and after four weeks of intake. The vertical axis represents eyelash length. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments of the present invention will be described in detail, but the present invention is not limited thereto.

[0011] The oral composition for hair growth of the present invention contains corosolic acid and polyamine, or loquat leaf extract and rice germ extract. It may also contain pea sprout extract. It may also contain one or more selected from biotin, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin E, and zinc compounds. Each component contained in the present invention is described in detail below.

[0012] Corosolic acid is a triterpene compound classified as an ursane-type triterpene. In the present invention, the origin and production method of corosolic acid are not particularly limited. Corosolic acid may be synthetic or extracted from plants containing corosolic acid. Examples of plants containing corosolic acid include quince, almond, banaba leaf, cranberry, loquat leaf, and perilla leaf. When extracted from plants, the extraction solvent is not particularly limited, but examples include water, alcohol (e.g., methanol, ethanol, n-propanol, n-butanol, etc.), and acetone, with water and / or ethanol being preferred. In one embodiment, corosolic acid may be extracted from loquat (Eriobotrya japonica Lindley) leaves, and extraction with aqueous ethanol is preferred. Commercially available corosolic acid and loquat leaf extracts can also be used. It is also preferable to use loquat leaf extract powdered with dextrin and modified starch.

[0013] In the oral hair-growth composition of the present invention, the amount of corosolic acid may be appropriately determined depending on the food form, etc., but may be, for example, 0.001% to 10% by weight, preferably 0.005% to 1% by weight, and more preferably 0.01% to 0.5% by weight. When loquat leaf extract is added, the amount may be appropriately determined depending on the food form, etc., but may be, for example, 0.1% to 50% by weight, preferably 0.5% to 30% by weight, and more preferably 1% to 20% by weight.

[0014] The daily intake of corosolic acid is usually 0.001 mg or more, preferably 0.01 mg or more, more preferably 0.1 mg or more, and usually 10 mg or less, preferably 5 mg or less, more preferably 3 mg or less. The daily intake of loquat leaf extract is usually 0.1 mg or more, preferably 1 mg or more, more preferably 2 mg or more, and usually 1000 mg or less, preferably 500 mg or less, more preferably 300 mg or less.

[0015] Polyamines, a general term for aliphatic hydrocarbons with two or more primary amino groups, are naturally occurring substances ubiquitously present in living organisms, and more than 20 types of polyamines have been discovered. Examples include 1,3-diaminopropane, putrescine, cadaverine, caldine, spermidine, homospermidine, aminopropylcadaverine, thermine, spermine, thermospermine, canavalmine, aminopentylnorspermidine, N,N-bis(aminopropyl)cadaverine, homospermine, caldopentamine, homocaldopentamine, caldohexamine, and homocaldohexamine. In the present invention, polyamines preferably contain putrescine, spermidine, and spermine. The origin and production method of polyamines are not particularly limited. Polyamines may be synthetic or extracted from plants containing polyamines. Examples of plants containing polyamines include rice and wheat. When polyamines are obtained by extraction from plants, the extraction solvent is not particularly limited, but examples include water, alcohols (e.g., methanol, ethanol, n-propanol, n-butanol, etc.), acetone, etc., and preferably, an aqueous citric acid solution can be used. In one aspect, the polyamines may be extracted from rice germ, and the extraction method is preferably extraction with an aqueous citric acid solution. Commercially available polyamines and rice germ extracts can also be used. Furthermore, it is preferable to use a rice germ extract powdered together with a starch hydrolysate.

[0016] In the oral composition for hair growth of the present invention, the amount of polyamine to be added may be appropriately determined depending on the form of the food, etc., and may be, for example, 0.001% to 10% by weight, preferably 0.005% to 1% by weight, and more preferably 0.01% to 0.5% by weight. The amount of rice germ extract to be added may be appropriately determined depending on the form of the food, etc., and may be, for example, 1% to 50% by weight, preferably 2% to 40% by weight, and more preferably 3% to 30% by weight.

[0017] The daily intake of polyamines is usually 0.001 mg or more, preferably 0.01 mg or more, more preferably 0.05 mg or more, and usually 10 mg or less, preferably 5 mg or less, more preferably 3 mg or less. The daily intake of rice germ extract is usually 1 mg or more, preferably 10 mg or more, more preferably 20 mg or more, and usually 2000 mg or less, preferably 1000 mg or less, more preferably 500 mg or less.

[0018] The pea sprout extract is obtained by extraction from pea sprouts. The extraction solvent is not particularly limited, but examples include water, alcohol (e.g., methanol, ethanol, n-propanol, n-butanol, etc.), acetone, etc., and preferably water and / or ethanol. A commercially available pea sprout extract can also be used. It is also preferable to use a pea sprout extract powdered together with isomaltooligosaccharide.

[0019] In the oral composition for hair growth of the present invention, the amount of bean sprout extract to be incorporated may be appropriately determined depending on the form of the food, etc., but is, for example, 0.1% by weight to 25% by weight, preferably 0.5% by weight to 10% by weight, and more preferably 1% by weight to 5% by weight.

[0020] The daily intake of bean sprout extract is usually 0.1 mg or more, preferably 1 mg or more, more preferably 2 mg or more, and usually 200 mg or less, preferably 100 mg or less, more preferably 50 mg or less.

[0021] In the oral composition for hair growth of the present invention, the ratio of loquat leaf extract to rice germ extract is 1:0.1 to 1:10, preferably 1:0.5 to 1:7, and more preferably 1:1 to 1:5. The ratio of loquat leaf extract to pea sprout extract is 1:0.1 to 1:5, preferably 1:0.2 to 1:3, and more preferably 1:0.3 to 1:1.

[0022] Biotins refer to biotin, its derivatives, and salts thereof. The types of biotins used in the present invention are not particularly limited, as long as they can be incorporated into foods. Salts of biotin and its derivatives include, for example, alkaline earth metal salts such as calcium salts; and ammonium salts. These biotins may be used alone or in combination of two or more.

[0023] Vitamin A refers to vitamin A1 (retinol, retinal, retinoic acid), vitamin A2 (3-dehydroretinol, 3-dehydroretinal, 3-dehydroretinoic acid), and derivatives thereof. The type of vitamin A used in the present invention is not particularly limited, as long as it can be incorporated into foods. These vitamin A compounds may be used alone or in combination of two or more.

[0024] Vitamin B1 refers to vitamin B1 (thiamine), its derivatives, and their salts. The type of vitamin B1 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B1 and its derivatives include inorganic acid salts such as hydrochloride, nitrate, and sulfate. These vitamin B1 compounds may be used alone or in combination of two or more.

[0025] Vitamin B2 refers to vitamin B2 (riboflavin), its derivatives, and salts thereof. The type of vitamin B2 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B2 and its derivatives include inorganic acid salts such as hydrochloride and nitrate. These vitamin B2s may be used alone or in combination of two or more.

[0026] Vitamin B6 refers to vitamin B6 (pyridoxine), its derivatives, and salts thereof. The type of vitamin B6 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B6 and its derivatives include, for example, inorganic acid salts such as hydrochloride. These vitamin B6 compounds may be used alone or in combination of two or more.

[0027] Vitamin B12 compounds refer to vitamin B12 (cyanocobalamin), its derivatives, and salts thereof. The type of vitamin B12 compounds used in the present invention is not particularly limited, as long as they can be incorporated into foods. In addition, salts of vitamin B12 and its derivatives include, for example, inorganic acid salts such as hydrochloride and nitrate. These vitamin B12 compounds may be used alone or in combination of two or more.

[0028] Vitamin C refers to vitamin C (ascorbic acid), its derivatives, and their salts. The type of vitamin C used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, examples of salts of vitamin C and its derivatives include alkali metal salts such as sodium salt and potassium salt. These vitamin C compounds may be used alone or in combination of two or more.

[0029] Vitamin E refers to vitamin E (tocopherol, tocotrienol) and its derivatives. The type of vitamin E used in the present invention is not particularly limited, as long as it can be incorporated into foods. Examples of vitamin E derivatives include tocopherol organic acid esters such as tocopherol acetate, tocopherol succinate, tocopherol linoleate, tocopherol linolenate, tocopherol nicotinate, and tocopherol (linoleate / oleate). These vitamin E compounds may be used alone or in combination of two or more.

[0030] The zinc compound refers to zinc salts or zinc yeasts enriched with zinc by adding zinc salts to yeast cultures to allow the yeast to incorporate zinc. The type of zinc compound used in the present invention is not particularly limited, as long as it can be incorporated into foods. Examples of zinc salts include zinc chloride, zinc sulfate, zinc gluconate, zinc lactate, and zinc citrate. These zinc compounds may be used alone or in combination of two or more.

[0031] The oral composition for hair growth of the present invention may contain other nutritional components or pharmacological components in addition to the above-mentioned components. Such nutritional components and pharmacological components are not particularly limited as long as they are usable in foods and oral medicines, and examples thereof include amino acids, minerals, carbohydrates, animal fats and oils, vegetable fats and oils, fatty acids, flavorings, seasonings, plant extracts, etc. These components may be used alone or in combination of two or more. The content of these components is appropriately determined depending on the type of additives used and the intended use of the oral composition.

[0032] Furthermore, in order to prepare the oral composition for hair growth of the present invention into a desired formulation, it may contain, as necessary, bases, additives, etc. in addition to the above-mentioned components. Such bases and additives are not particularly limited as long as they are usable in foods and pharmaceuticals, and examples thereof include water, lower alcohols, higher alcohols, water-soluble polymers, surfactants, polyhydric alcohols, pH adjusters, buffers, antioxidants, preservatives, thickeners, chelating agents, etc. These may be used alone or in combination of two or more. The content of these bases and additives is appropriately determined depending on the types of components used and the intended use of the oral composition.

[0033] The form of the oral composition for hair growth of the present invention is not particularly limited as long as it can be orally ingested or administered, and may be any of solid, semi-solid, or liquid, and may be appropriately selected depending on the type and use of the oral composition.

[0034] The uses of the oral composition for hair growth of the present invention are not particularly limited as long as it can be orally ingested or administered, and specific examples include foods and beverages and oral medicines. Foods and beverages include general foods and beverages as well as foods for specified health uses, nutritional supplements, functional foods, and foods for the sick. When made into beverages, they can be made into nutritional drinks, soft drinks, carbonated drinks, lactic acid drinks, etc., and when made into foods, they can be made into luxury items such as gummies and candies.

[0035] When the oral composition for hair growth of the present invention is formulated, the dosage form is not particularly limited, and examples thereof include capsules (soft capsules, hard capsules), tablets, granules, powders, jellies, etc. Among these, capsules, tablets, granules, and powders are preferred, capsules are more preferred, and soft capsules are particularly preferred. When the oral composition for hair growth of the present invention is formulated as a capsule, the content ratio of each component described above means the content ratio in the contents of the capsule.

[0036] The base material used in soft capsules is not particularly limited, but examples thereof include vegetable oils and fats, animal oils and fats, etc.

[0037] Examples of vegetable oils include, but are not limited to, olive oil, linseed oil, wheat germ oil, safflower oil, perilla oil, soybean oil, camellia oil, corn oil, peppermint oil, castor oil, cottonseed oil, coconut oil, peanut oil, and refined oils derived from vegetable oils.

[0038] The animal fats and oils are not particularly limited, but examples thereof include fish oil, egg yolk oil, beef tallow, lard, refined oils derived from animal fats and oils, and the like.

[0039] Refined oils derived from animal fats include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA is found in large amounts in tuna, monkfish, mackerel, saury, yellowtail, horse mackerel, eel, salmon, sardines, etc. EPA is found in large amounts in tuna, mackerel, saury, yellowtail, horse mackerel, sardines, red sea bream, flounder, etc.

[0040] In one embodiment, the oil preferably includes vegetable oil. Compared to animal oil, vegetable oil has almost no taste or odor, and therefore soft capsules that are easy to ingest can be obtained. In another embodiment, the oil preferably includes at least one of linseed oil and safflower oil, and more preferably includes linseed oil.

[0041] The emulsifier used in soft capsules is not particularly limited, but examples thereof include lecithin, glycerin fatty acid ester, sucrose fatty acid ester, saponin, wax, and the like.

[0042] Lecithin is a glycerophospholipid containing glycerin, choline, and fatty acids. Examples of the fatty acids include palmitic acid, stearic acid, oleic acid, linoleic acid, and α-linolenic acid. Lecithin is usually a mixture of glycerophospholipids. Lecithin can be obtained by extraction from chicken eggs, soybeans, rapeseed, beef, etc. Among these, soybean lecithin and egg yolk lecithin are preferred, and soybean lecithin is more preferred. The composition of the glycerophospholipids contained in lecithin can be appropriately adjusted, for example, by selecting raw materials, extraction methods, purification methods, etc.

[0043] Glycerin fatty acid esters have a structure in which a fatty acid is ester-bonded to one or two of the three hydroxyl groups of glycerin. Examples of glycerin fatty acid esters include, but are not limited to, acetate monoglyceride, lactate monoglyceride, citrate monoglyceride, diacetyltartarate monoglyceride, succinate monoglyceride, polyglycerin fatty acid ester, and polyglycerin condensed linosyl acid ester.

[0044] Sucrose fatty acid esters have a structure in which sucrose is esterified with a fatty acid to 1 to 8, preferably 1 to 3, of the eight hydroxyl groups of sucrose. Examples of sucrose fatty acid esters include, but are not limited to, sucrose stearate, sucrose palmitate, sucrose myristate, sucrose oleate, sucrose laurate, sucrose behenate, sucrose erucate, and sucrose mixed fatty acid (oleate / palmitate / stearate) ester.

[0045] Saponins are glycosides containing sapogenin (aglycone) with a triterpene or steroid skeleton and a sugar chain. There are a variety of molecular species depending on the aglycone structure, sugar chain structure, and whether or not the sugar chain has been modified (acetylated, etc.) with a hydroxyl group. Specific examples of saponins include soybean saponin, onjisaponin, platycodon saponin, senegasaponin, and ginsenoside.

[0046] Wax, also called wax, is an ester of fatty acids and alcohol obtained from plants and animals. Specific examples of wax include beeswax, white beeswax, carnauba wax, rice bran wax, carnauba wax, and lanolin.

[0047] The gelling agent used in soft capsules is not particularly limited, but examples thereof include gelatin, casein, polysaccharides, starches, and the like.

[0048] Examples of gelatin include beef gelatin, pork gelatin, chicken gelatin, fish gelatin, and gelatin derivatives. In this case, examples of the gelatin derivatives include cross-linked gelatin cross-linked with organic compounds (methacrylic acid, acrylic acid, (poly)lactic acid, methacrylamide, etc.), gelatin hydrolysates, etc.

[0049] Examples of the polysaccharides include carrageenan, agar, sodium alginate, pullulan, glucomannan, gum arabic, welan gum, xanthan gum, gellan gum, tragacanth gum, locust bean gum, pectin, polydextrose, dextrin, maltodextrin, cyclodextrin, indigestible dextrin, guar gum, psyllium seed gum, hydroxypropyl cellulose, hydroxypropylmethylcellulose, methylcellulose, carboxymethylcellulose, and chitosan.

[0050] Starches include, but are not limited to, natural starches and modified starches.

[0051] The natural starch is not particularly limited, but examples thereof include potato starch, tapioca starch, glutinous corn starch, glutinous rice starch, sago starch, sweet potato starch, mung bean starch, and wheat starch.

[0052] The term "hair growth" in the oral composition for hair growth of the present invention includes not only the prevention of hair loss, hair growth, hair elongation, and promotion of hair growth, but also concepts such as increasing the volume by increasing the length and thickness, and providing firmness and resilience.

[0053] The oral composition for hair growth of the present invention has a hair-growing effect on body hair such as hair and eyelashes, and in particular, has a hair-growing effect on eyelashes.

[0054] The oral composition for hair growth of the present invention can be administered or taken once a day or divided into multiple doses (for example, 2 to 3 doses) a day.

[0055] The oral composition for hair growth of the present invention can be administered or taken for a long period of time, for example, continuously for two or more days, three or more days, five or more days, one or more weeks, two or more weeks, three or more weeks, one or more months, two or more months, three or more months, four or more months, five or more months, six or more months, seven or more months, eight or more months, or longer. [Example]

[0056] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0057] An ingestion test was conducted on the oral composition for hair growth of the present invention. The composition of the oral composition for hair growth used is as shown in Table 1, and it was ingested in the form of a soft capsule. The soft capsule had a capsule shell mainly composed of gelatin and glycerin, and was produced by a punching method using a rotary mold capsule filling machine.

[0058] [Table 1]

[0059] In Table 1, the sources and raw material names of the loquat leaf extract powder, rice germ extract powder, and bean sprout extract powder used are as follows: Loquat leaf extract powder: "Loquat Leaf Extract Powder T (contains loquat leaf extract containing corosolic acid, dextrin, and modified starch, with a corosolic acid content of approximately 0.50%)" (manufactured by Maruzen Pharmaceuticals Co., Ltd.) Rice germ extract powder: "Oryza Polyamine-P (contains rice germ extract containing polyamines, starch hydrolysate, and citric acid; polyamine content is approximately 0.2%)" (Oryza Oil & Fat Chemical Co., Ltd.) Bean sprout extract powder: "AnaGain (containing pea sprout extract and isomaltooligosaccharides)" (Mibelle AG Biochemistry)

[0060] How to take Fourteen male and female subjects (aged 24 to 58 years) took two soft capsules containing the oral hair growth composition shown in Table 1 daily for four weeks.

[0061] "Evaluation of the experience" 1. Evaluation Method After four weeks of intake, 14 subjects completed a free-form questionnaire about the "perceived effects on eyelashes."

[0062] 2.Results Of the 14 people who took the product, 7 responded that it had an effect on their eyelashes. The effects observed were as follows: I feel like I'm losing fewer eyelashes It felt like it was longer My eyelashes are less likely to fall out and I feel like they have more volume. - The curler now fits better When I curl my eyelashes with makeup, I notice the short hairs. I've never noticed this before, so I think it might be because new hairs are growing. Some eyelashes are now pointing upwards I wasn't aware of it, but when I measured it, I was surprised to see that it had grown.

[0063] From the above, it was confirmed that ingesting a composition containing loquat leaf extract and rice germ extract has a hair growth effect on eyelashes.

[0064] "Eyelash length measurement" 1. Evaluation Method The length of the left and right eyelashes of 14 subjects was measured before, two weeks after, and four weeks after intake. The length of the eyelashes was measured at the center with the eyes closed, and the average length of each eyelash was calculated. The results are shown in Figure 1.

[0065] 2.Results The average length of both the right and left eyelashes was longer after two weeks of intake than before intake, and was even longer after four weeks of intake.

[0066] From the above, it was confirmed that ingesting a composition containing loquat leaf extract and rice germ extract has an eyelash lengthening effect.

Claims

1. An oral composition for hair growth containing corosolic acid and a polyamine.

2. An oral composition for hair growth containing loquat leaf extract and rice germ extract.

3. 3. The oral composition for hair growth according to claim 2, further comprising a pea sprout extract.

4. 4. The oral composition for hair growth according to claim 3, containing loquat leaf extract, rice germ extract, and pea sprout extract in a ratio of 1:1-5:0.3-1.

5. 3. The oral composition for hair growth according to claim 1 or 2, which is used for lengthening eyelashes.

6. 3. The oral composition for hair growth according to claim 1 or claim 2, further comprising one or more selected from biotins, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin E, and zinc compounds.

7. A capsule containing the oral composition for hair growth according to any one of claims 1 to 6.

8. The oral composition for hair growth according to any one of claims 1 to 6, which is in the form of granules or tablets.

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