Extracorporeal circulation circuit

Abstract

To prevent unintended deformation of a pump tube by an adapter component from occurring easily.SOLUTION: An extracorporeal circulation circuit 100 includes a pump tube unit 101. The pump tube unit 101 includes a pump tube 110 and a cassette 120. The cassette 120 has a first holding portion 122A for holding a first held portion 113A and a second holding portion 122B for holding a second held portion 113B. In a use preparation state in which the first held portion 113A and the second held portion 113B are held by the first holding portion 122A and the second holding portion 122B respectively, at least one of the first held portion 113A and the second held portion 113B is rotatable in the periaxial direction of the pump tube 110.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present disclosure relates to extracorporeal circulation circuits. [Background technology]

[0002] In extracorporeal circulation treatments such as dialysis, an extracorporeal circuit is used to extract blood from a patient, process it, and then return it to the patient. The extracorporeal circuit is equipped with a pump tube that is curved and attached to a roller pump. The pump tube is rotated by the rotating rotor of the roller pump to pump the blood.

[0003] To facilitate attachment of a pump tube to a roller pump, it has been considered to fix the pump tube in a pre-bent state to an adapter part such as a plate (see, for example, Patent Document 1). The pump tube has both ends fixed to the adapter parts to form a U-shape, and by attaching the adapter parts to the housing of the roller pump, the pump tube can be easily engaged with the rotor of the roller pump. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Special Publication No. 2007-537390 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the curved portion of the pump tubing, which has both ends fixed to the adapter parts, is constantly under stress. If the pump tubing is sterilized or stored for a long period of time in this state, it may be deformed unintentionally. Deformed pump tubing may not be properly attached to the pump or may cause problems when the rotor is rotated.

[0006] An object of the present disclosure is to realize an extracorporeal circulation circuit in which unintended deformation of the pump tube due to adapter parts is unlikely to occur. [Means for solving the problem]

[0007] A first aspect of the extracorporeal circulation circuit of the present disclosure includes a pump tube unit that is assembled to a roller pump, the pump tube unit having a pump tube and a cassette that holds the pump tube and is attached to the roller pump, the pump tube having a pump tube body and a first held portion provided at a first end of the pump tube body and a second held portion provided at a second end, the cassette having a first holding portion that holds the first held portion and a second holding portion that holds the second held portion, and the first held portion and the second held portion are held by the first holding portion and the second holding portion, respectively, thereby setting the pump tube in a ready-to-use state in which the relative position of the pump tube to the cassette is fixed, and in the ready-to-use state, at least one of the first held portion and the second held portion is rotatable around the axis of the pump tube.

[0008] In a first aspect of the extracorporeal circuit, at least one of the first and second held portions is rotatable around the axis of the pump tube. This allows the pump tube to rotate in a manner that relieves stress applied to the pump tube, making it less likely to undergo unintended deformation even when held by the holding plate. Furthermore, since the pump tube can rotate to eliminate twisting even during operation of the roller pump, there is also the advantage of reducing the load applied to the pump tube during operation. Furthermore, the tolerance for twisting of the pump tube during assembly is increased, improving the ease of assembly of the pump tube unit.

[0009] In the first aspect of the extracorporeal circuit, at least one of the first holding part and the second holding part can be configured to be able to transition from a state in which it releases the holding of the corresponding first held part and second held part to a state in which it holds them. This configuration allows the pump tube to be sterilized or stored in a state in which it is released from holding and is not subjected to stress, making it even less likely that unintended deformation will occur.

[0010] In this case, at least one of the first holding part and the second holding part can be a member with a C-shaped cross section having a hollow part into which the corresponding first held part and second held part are inserted. By configuring in this way, a holding part that is rotatable and can be easily held and released can be realized.

[0011] In a first aspect of the extracorporeal circuit, the cassette has a first part and a second part that can be moved from a separated state to a connected state, the first part having a first holding part, and the second part having a second holding part. With this configuration, the cassette can be sterilized or stored in a separated and stress-free state, further reducing the likelihood of unintended deformation.

[0012] In this case, the first and second parts may have the same shape, which improves productivity because only one part needs to be manufactured and the pump tube can be fixed in the same procedure.

[0013] A first aspect of the extracorporeal circulation circuit packaging of the present disclosure comprises an extracorporeal circulation circuit and a bag in which the extracorporeal circulation circuit is housed in a sterilized state, the extracorporeal circulation circuit having a pump tube unit assembled to a roller pump, the pump tube unit having a pump tube and a cassette that holds the pump tube and is attached to the roller pump, the pump tube having a pump tube body and a first held portion provided at a first end of the pump tube body and a second held portion provided at a second end, the cassette having a first part having a first holding portion that holds the first held portion and a second part having a second holding portion that holds the second held portion, the extracorporeal circulation circuit being sterilized and housed in the bag in a disconnected state in which the first part and the second part are separated, and being capable of being moved to a ready-to-use state in which the first part and the second part are connected.

[0014] According to the first aspect of the extracorporeal circulation circuit packaging, the cassette can be separated into the first and second parts and stored in a sterile state without being subjected to stress, making it less likely to undergo unintended deformation.

[0015] In the first aspect of the extracorporeal circuit package, the first and second parts can have the same shape. This configuration allows only one part to be manufactured, and the pump tube can also be fixed using the same procedure, improving productivity.

[0016] A second aspect of the extracorporeal circulation circuit packaging of the present disclosure comprises an extracorporeal circulation circuit and a bag in which the extracorporeal circulation circuit is housed in a sterilized state, the extracorporeal circulation circuit having a pump tube unit assembled to a roller pump, the pump tube unit having a pump tube and a cassette that holds the pump tube and is attached to the roller pump, the pump tube having a pump tube body and a first held portion provided at a first end of the pump tube body and a second held portion provided at a second end, the cassette having a first holding portion that holds the first held portion and a second holding portion that holds the second held portion, and the extracorporeal circulation circuit is sterilized and housed in the bag in a state in which at least one of the holding of the first held portion by the first holding portion and the holding of the second held portion by the second holding portion is released.

[0017] In a second aspect of the extracorporeal circulation circuit package, the package is sterilized and housed in the bag with at least one of the first and second held portions released from their holding state, so that the pump tube remains free of stress until immediately before use, making it less likely for the pump tube to kink. [Effects of the Invention]

[0018] According to the extracorporeal circulation circuit of the present disclosure, unintended deformation of the pump tube due to the adapter parts can be made less likely to occur. [Brief explanation of the drawings]

[0019] [Figure 1] FIG. 2 is a plan view showing a state in which a pump tube unit of the extracorporeal circuit according to the first embodiment is assembled to a roller pump. [Figure 2] FIG. 4 is an enlarged plan view showing a holding portion of the pump tube unit. [Figure 3] FIG. 10 is an enlarged plan view showing a holding portion of the first modified example. [Figure 4] FIG. 1 is a plan view showing an example of an extracorporeal circuit in a sterile packaged state. [Figure 5]FIG. 10 is a plan view showing a second modified example of the pump tube unit. DETAILED DESCRIPTION OF THE INVENTION

[0020] 1, the extracorporeal circuit 100 of the first embodiment includes a pump tube unit 101 that is assembled to a roller pump 200. The pump tube unit 101 has a pump tube 110 and a cassette 120. An upstream line tube 151A is connected to a first end portion of the pump tube 110 on the upstream side, and a downstream line tube 151B is connected to a second end portion of the pump tube 110 on the downstream side.

[0021] The pump tube 110 has a pump tube main body 112 and a held portion 113 provided at an end of the pump tube main body 112. The held portion 113 includes a first held portion 113A on the first end side and a second held portion 113B on the second end side. The cassette 120 has a holding plate main body 121 and a holding portion 122 fixed to the holding plate main body 121. The holding portion 122 includes a first holding portion 122A that holds the first held portion 113A of the pump tube 110 and a second holding portion 122B that holds the second held portion 113B. The shape of the holding plate main body 121 can be changed to match the roller pump 200 to be assembled. In this embodiment, the first held portion 113A and the second held portion 113B have the same configuration, and the first holding portion 122A and the second holding portion 122B also have the same configuration.

[0022] 2, the holding portion 122 in this embodiment is a cylindrical member fixed to the holding plate main body 121. The held portion 113 is inserted into the inner cavity of the holding portion 122 and held therein. Because the inner diameter of the holding portion 122 is slightly larger than the outer diameter of the held portion 113, the held portion 113 inserted into the holding portion 122 can rotate around the axis of the pump tube 110 as the rotation center. Meanwhile, the relative position of the pump tube 110 with respect to the cassette is fixed, and the pump tube unit 102 is in a ready-to-use state in which it can be assembled to the roller pump 200.

[0023] In this embodiment, flanges 115 and 116 having an outer diameter larger than the inner diameter of the holding portion 122 are provided on both ends of the held portion 113 so that the relative position of the pump tube 110 with respect to the cassette is fixed. The flanges 115 and 116 restrict axial movement of the held portion 113 relative to the holding portion 122. Although a configuration in which flanges are provided on both ends of the held portion 113 has been shown, a configuration in which only the outer flange 116 is provided is also possible. Furthermore, axial movement of the held portion 113 can be restricted by other configurations besides flanges.

[0024] In this embodiment, the held portion 113 is a part of the connector 114 for connecting to the line tube 151, which is fixed to the end of the pump tube main body 112. However, the held portion 113 can be a separate member from the connector 114. For example, a member attached to the pump tube main body 112 separately from the connector 114 can be the held portion, or the outer surfaces of both ends of the pump tube main body 112 can be the held portion. When the outer surfaces of both ends of the pump tube main body 112 are the held portion, the end of the connector 114 can be a flange 116 that restricts axial movement. Also, a step can be provided on the outer surface of the connector 114 for connecting different-diameter tubes, and this step can be used to restrict axial movement of the held portion. Note that it is preferable to minimize steps on the inner surface of the connector 114 to ensure smooth blood flow. Also, the line tube 151 side of the connector 114 can be the held portion. In this case, the outer surface of the line tube 151 can be used as the held portion, or a structure that serves as the held portion separate from the connection connector 114 can be connected to the line tube 151 .

[0025] The holding portion 122 and the held portion 113 are not limited to this configuration, and may have various configurations that can hold the held portion 113 rotatably around the axis.

[0026] In this embodiment, the held portions 113 held by the holding portions 122 are all fixed in position relative to the cassette 120 and are rotatable about their axes. With this configuration, the pump tube 110 can rotate in a manner that reduces stress even when fixed to the cassette 120. Therefore, even when the pump tube 110 is sterilized under high-temperature conditions or stored for a long period of time while held in the cassette 120, unintended deformation is less likely to occur.

[0027] In this embodiment, the first holding portion 122A and the second holding portion 122B have the same configuration, and both the first held portion 113A held by the first holding portion 122A and the second held portion 113B held by the second holding portion 122B are rotatable around the axis. However, the first holding portion 122A and the second holding portion 122B may have different configurations. In this case, one of the first holding portion 122A and the second holding portion 122B can be configured to hold the held portion 113 so that it does not rotate around the axis. For example, one of the held portions 113 can be configured to be directly bonded to the holding plate main body 121, or the pump tube main body 112 can be welded or glued to a tube connection connector molded integrally with the holding plate main body 121. If one of the held portions 113 is fixed but the other is rotatable around the axis, stress applied to the pump tube 110 can be reduced.

[0028] As shown in FIG. 1 , the pump tube unit 101 of this embodiment can be assembled to a roller pump 200. The roller pump 200 has a housing 201 to which the pump tube unit 101 is assembled. The housing 201 has a circular recess 211 and a rotor 212 provided in the recess 211. A plate fixing portion 221 to which a cassette 120 is fixed is provided on the outside of the recess 211 of the housing 201. A notch is provided in the peripheral wall of the recess 211 at the portion corresponding to the plate fixing portion 221. When the cassette 120 is fixed to the plate fixing portion 221, the pump tube main body 112 held by the cassette 120 is positioned in the recess 211 through the notch. The pump tube main body 112 in the recess 211 is pressed against the peripheral wall of the recess 211 by rollers 213 provided on the rotor 212. When the rotor 212 is rotated, the rollers 213 rub the pump tube body 112 , pumping out the liquid inside the pump tube body 112 and sucking the liquid into the pump tube body 112 .

[0029] If the pump tube body 112 continues to be handled by the rollers 213 in a twisted state, an abnormal load is applied to the pump tube body 112, and in the worst case, the pump tube body 112 may break. However, in the pump tube unit 101 of this embodiment, the held portion 113 of the pump tube 110 is rotatable about its axis, so even if the pump tube body 112 is handled by the rollers 213 in a twisted state, the held portion 113 rotates to remove the twist. This reduces the load applied to the pump tube body 112 during pump operation, making it less likely to be damaged.

[0030] The effect of eliminating twisting can be obtained not only when both the first held portion 113A and the second held portion 113B are rotatable, but also when only one of them is rotatable. When only one of the first held portion 113A and the second held portion 113B is rotatable, it is preferable to make the downstream second held portion 113B rotatable from the viewpoint of the effect of eliminating twisting. However, it is also possible to make the upstream first held portion 113A rotatable.

[0031] A pump tube unit 102 of a first modified example shown in FIG. 3 can also be used as a configuration for reducing stress applied to the pump tube 110. The pump tube unit 102 has a cassette 124 with a holding portion 126 having a C-shaped cross section and a slot 125. The pump tube unit shown in FIG. 2 is packaged in a ready-to-use state in which the pump tube and the cassette are pre-assembled, whereas the pump tube unit shown in FIG. 3, in which the holding portion 126 has a slot 125, can be packaged in a state in which at least a portion of the pump tube and the cassette are not assembled. After removing the pump tube unit shown in FIG. 3 from the package, the user can push the held portion 113 from the slot 125 into the inner cavity of the holding portion 126 to hold it. This allows the pump tube 110 to be ready-to-use in a state in which the held portion 113 can rotate about its axis but the relative position of the pump tube 110 with respect to the cassette 124 is fixed. In other words, sterilization and storage are performed in a released state where the held portion 113 is not held by the holding portion 126, and when the pump tube unit 102 is assembled to the roller pump 200, the pump tube unit 102 can be prepared for use in a held state where the held portion 113 is held by the holding portion 126. By performing sterilization and storage in a released state where no large stress is applied to the pump tube 110, deformation of the pump tube 110 due to stress can be reduced.

[0032] The holding portion 126, which has a C-shaped cross section and a slot 125, can be shifted from a release state to a holding state, and in the holding state, the held portion 113 can be rotated about its axis. This also has the effect of reducing stress during pump operation. However, the holding portion that can be shifted from a release state to a holding state is not limited to this configuration and various other configurations can be adopted. For example, a cassette and pump tube as described in WO2010 / 092729 may be used, and the cassette and pump tube may be packaged unassembled, with fitting projections and cylindrical recesses provided on the pump tube and cassette, allowing the user to assemble them.

[0033] Although the configuration has been shown in which after transitioning from the release state to the held state, the held portion 113 can be pulled out of the slot 125 to return to the release state again, from the viewpoint of preventing erroneous operation, it is also possible to make it so that once the state has been transitioned from the release state to the held state, it is not possible to return to the release state again. For example, when the held portion 113 is inserted to transition to the held state, it can pass through easily, but a protrusion can be provided in the slot 125 that will catch when an attempt is made to pull out the held portion to return to the release state, or a mechanism can be provided in which the held portion 113 is locked once it is inserted.

[0034] 4, the extracorporeal circulation circuit 100A having the pump tube unit 102 of this modification can be sterilized and stored in a sterilization bag 300 in a release state in which the second held portion 113B is not held by the second holding portion 126B. By putting the extracorporeal circulation circuit 100A in the release state, the pump tube main body 112 can be stored in the sterilization bag 300 in a gently curved state or in a straight state, preventing large stress from being applied to the pump tube main body 112. Just before use, the user can remove the extracorporeal circulation circuit 100A from the sterilization bag 300, hold the second held portion 113B in the second holding portion 126B, and assemble it to a tube pump.

[0035] 4, first holding portion 122A that holds the first held portion does not have slot 125. However, first holding portion 122A may be configured to be able to transition from a release state to a holding state, and first held portion 113A side may be in the release state for sterilization or storage. Also, both first held portion 113A side and second held portion 113B side may be in the release state for sterilization and storage. However, holding one of held portions 113 makes it less likely that cassette 124 will be dropped or that held portion 113 will be held by holding portion 122 on the opposite side.

[0036] 4 shows an example in which the pump tube main body 112 is gently curved inside the sterilization bag 300, but depending on the length of the pump tube main body 112 and the size of the sterilization bag 300, it is also possible to sterilize and store the pump tube main body 112 in a straightened state. The extracorporeal circulation circuit 100A can also be stored in a tray or the like and then stored inside the sterilization bag 300.

[0037] As a method for reducing stress, a pump tube unit 103 of a second modified example shown in FIG. 5 can also be used. A cassette 130 in the second modified example includes a first portion 131A having a first holding portion 132A that holds a first held portion 113A of a pump tube 110, and a second portion 131B having a second holding portion 132B that holds a second held portion 113B. The first portion 131A has a recess 135A and a protrusion 136A, and the second portion 131B has a recess 135B and a protrusion 136B. Engagement of the recess 135A with the protrusion 136B and the protrusion 136A with the recess 135B couples the first portion 131A and the second portion 131B together in a manner that restricts relative movement between them in both the long side direction connecting the first holding portion 132A and the second holding portion 132B and the short side direction intersecting the long side direction. This puts the pump tube unit 103 into a ready-to-use state.

[0038] During sterilization or storage, first portion 131A and second portion 131B are separated and disconnected, thereby preventing large stresses from being applied to pump tube body 112 and suppressing deformation of pump tube body 112. For example, first portion 131A and second portion 131B can be placed in a sterilization bag in a separated and disconnected state, sterilized, and stored in that state. When removing the pump from the sterilization bag and assembling it to a pump, the user can easily connect first portion 131A and second portion 131B together to prepare for use.

[0039] In this embodiment, the first portion 131A and the second portion 131B have the same shape. This allows for the production of only one part, thereby improving production efficiency. However, the first portion 131A and the second portion 131B can also have different shapes. By making the first portion 131A and the second portion 131B have different shapes, the degree of freedom in designing the connecting portion and the holding portion is improved. When the first portion 131A and the second portion 131B have different shapes, the sizes of both portions can be made approximately the same, or portions of different sizes can be combined.

[0040] In this embodiment, the first holding portion 132A and the second holding portion 132B respectively hold the first held portion 113A and the second held portion 113B so that they can rotate about the axis. This configuration also alleviates stress caused by twisting of the pump tube main body 112 during pump operation. However, the first holding portion 132A and the second holding portion 132B can also be configured so that the held portion 113 they hold does not rotate. If the first portion 131A and the second portion 131B have different shapes, one of the first holding portion 132A and the second holding portion 132B can also be configured so that the held portion 113 is rotatable and the other is configured so that it is not rotated.

[0041] In this embodiment, the connecting portions connecting the first portion 131A and the second portion 131B are formed by a convex portion and a concave portion provided on each portion. By arranging the convex portion and the concave portion symmetrically, the first portion 131A and the second portion 131B can be formed to have the same shape. However, the convex portion and the concave portion can also be arranged asymmetrically. Furthermore, by providing a convex portion and a concave portion on each portion, the first portion 131A and the second portion 131B are connected at two points, making it difficult for rotation to occur around the connecting portion as an axis. However, it is also possible for the first portion 131A and the second portion 131B to be connected by a single convex portion and a concave portion. In this case, the convex portion and the concave portion can be formed to have an angular shape, such as a triangular or rectangular shape, to suppress rotation around the connecting portion as an axis. The concave portion can be a non-through hole or a through hole.

[0042] Furthermore, the connecting portion is not limited to a combination of a convex portion and a concave portion, and various other configurations are possible. For example, a convex rail may be provided on one side and a concave rail on the other, and the two may engage by sliding, or one may be inserted inside the other, and the two may engage, or the two may be provided with notches to form complementary hook-shaped portions, which engage with each other. Because a load is applied to the cassette when the roller pump is rotated, it is preferable to form multiple connecting portions. In this embodiment, convex portions and concave portions are formed on each of the first portion 131A and the second portion 131B. Furthermore, although the connecting portions are arranged side by side in the short-side direction of the cassette (the left-right direction in FIG. 5), they can also be arranged side by side in the long-side direction (the up-down direction in FIG. 5). Furthermore, when the connecting portion is a combination of a convex portion and a concave portion, it is preferable to form the concave portion as a through-hole, as this increases the fixing force between the first portion 131A and the second portion 131B.

[0043] Although the first part 131A and the second part 131B are configured to be connectable and separable, they can also be configured to be difficult to separate once connected. For example, the convex part can be shaped to have a portion that gradually expands in diameter toward the base and a portion that contracts in diameter, or to have multiple elastic claws with folded portions, so that when transitioning from the disconnected state to the ready-to-use state, the convex part can be easily inserted into the recessed part but cannot be easily pulled out of the recessed part. This configuration is not limited to these, and other configurations can also be used to restrict the re-transition from the ready-to-use state to the disconnected state.

[0044] At least one of the first holding portion 132A and the second holding portion 132B can be configured so that the held portion 113 can rotate about the axis. This configuration has the effect of eliminating twisting during pump operation. However, even if both the first holding portion 132A and the second holding portion 132B are configured so that the held portion 113 does not rotate about the axis, stress during sterilization and storage can be reduced. In addition, the attachment structure between the cassette and the pump tube can also be configured as described in WO2010 / 092729 or WO2019 / 065480.

[0045] As methods for reducing the load on the pump tube, a method for allowing the pump tube to rotate around an axis relative to the cassette, a method for allowing the pump tube to be released from the cassette, and a method for allowing the cassette to be separated into multiple parts have been exemplified. Each of these exemplified methods can reduce the load on the pump tube alone, but multiple methods can also be combined.

[0046] The configuration for assembling the cassette to the plate fixing portion of the roller pump is not particularly limited and various configurations can be employed. For example, as described in WO 2010 / 092729, a configuration in which the cassette and the roller pump housing are provided with engaging recesses and grooves for fitting together can be used. Alternatively, as described in WO 2019 / 065480, a configuration in which an engaging claw and an engaging groove for inserting the engaging claw are provided on the cassette and the housing at one end of the long sides of the cassette and the plate fixing portion, and the engaging claw is inserted into the engaging groove, and the cassette is then rotated around this portion as an axis to fit into the plate fixing portion. In this case, engaging recesses or grooves can also be provided on the other end of the cassette and the plate fixing portion. In this way, using a fitting portion that fits into a recess in the roller pump housing at both ends of the long sides of the cassette is preferable because it reduces the likelihood of the first and second portions separating due to the squeezing action of the rollers, even in a cassette that can be separated into a first and second portion.

[0047] In one embodiment and each modified example, an example is shown in which the pump tube is held in the cassette so that the extension line of the first end and the extension line of the second end of the pump tube are parallel, but as shown in WO2010 / 092729 and WO2019 / 065480, the pump tube can also be configured to be held in the cassette so that the extension line of the first end and the extension line of the second end intersect. [Industrial Applicability]

[0048] The extracorporeal circulation circuit of the present disclosure is less likely to cause unintended deformation of the pump tube due to adapter parts, and is therefore useful in the medical field. [Explanation of symbols]

[0049] 100, 100A extracorporeal circulation circuit 101, 102, 103 Pump tube unit 110 Pump Tube 112 Pump tube body 113 Holding part 113A First held part 113B second held portion 114 Connection connector 115, 116 flange part 120 cassettes 121 Retaining plate body 122 Holding part 122A First holding part 122B Second holding part 124 cassettes 125 slots 126 Holding part 126B Second holding part 130 cassettes 131A First Part 131B Second part 132A First holding part 132B Second holding part 135A, 135B recess 136A, 136B convex part 151 Line Tube 151A Upstream line tube 151B Downstream Line Tube 200 Roller Pump 201 Housing 211 recess 212 rotor 213 Roller 221 Plate fixing part 300 sterile bags

Claims

1. A pump tube unit is provided which can be assembled to the roller pump. the pump tube unit includes a pump tube, a cassette attached to the roller pump, and a first held portion and a second held portion that hold the pump tube in the cassette; the cassette has a first holding portion that holds the first held portion and a second holding portion that holds the second held portion; An extracorporeal circulation circuit, wherein in a ready-to-use state in which the first held portion and the second held portion are held by the first holding portion and the second holding portion, respectively, at least one of the first held portion and the second held portion is rotatable around the axis of the pump tube.

2. The extracorporeal circulation circuit according to claim 1, wherein at least one of the first holding portion and the second holding portion is capable of transitioning from a released state in which the holding of the corresponding first held portion and the second held portion is released to a held state in which the holding of the corresponding first held portion and the second held portion is held.

3. 3. The extracorporeal circulation circuit according to claim 2, wherein at least one of the first holding portion and the second holding portion is a member having a C-shaped cross section and a hollow portion into which the corresponding first held portion and second held portion are inserted.

4. the cassette has a first portion and a second portion that can be moved from a separated state to a connected state; The extracorporeal circulation circuit according to claim 1 , wherein the first portion has the first holding portion and the second portion has the second holding portion.

5. The extracorporeal circulation circuit according to claim 4 , wherein the first portion and the second portion have the same shape.

6. an extracorporeal circulation circuit; and a bag in which the extracorporeal circulation circuit is accommodated in a sterilized state; the extracorporeal circuit has a pump tube unit assembled to a roller pump; the pump tube unit includes a pump tube, a cassette attached to the roller pump, and a first held portion and a second held portion that hold the pump tube in the cassette; the cassette has a first portion having a first holding portion that holds the first held portion and a second portion having a second holding portion that holds the second held portion; The extracorporeal circulation circuit package is sterilized and housed within the bag in a disconnected state in which the first part and the second part are separated, and is capable of being moved to a ready-to-use state in which the first part and the second part are connected.

7. The extracorporeal circuit package according to claim 6 , wherein the first portion and the second portion have the same shape.

8. an extracorporeal circulation circuit; and a bag in which the extracorporeal circulation circuit is accommodated in a sterilized state; the extracorporeal circuit has a pump tube unit assembled to a roller pump; the pump tube unit includes a pump tube, a cassette attached to the roller pump, and a first held portion and a second held portion that hold the pump tube in the cassette; the cassette has a first holding portion that holds the first held portion and a second holding portion that holds the second held portion, The extracorporeal circulation circuit package is sterilized and contained within the bag in a released state in which at least one of the holding of the first held portion by the first holding portion and the holding of the second held portion by the second holding portion is released, and is capable of transitioning to a ready-to-use state in which the first held portion is held by the first holding portion and the second held portion is held by the second holding portion.

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