Sterilization combination

Abstract

The present disclosure relates to a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide.The present disclosure also relates to a fungicidal composition comprising the fungicidal combination and at least one pesticidally acceptable excipient.Furthermore, the present disclosure relates to a method for controlling the growth of fungal diseases in plants, comprising applying a fungicidal composition comprising the fungicidal combination to a plant, or to a locus or plant propagation material thereof.

Description

[Technical field]

[0001] The present disclosure relates to a fungicidal combination for controlling fungal diseases. The present disclosure also relates to a fungicidal composition comprising said fungicidal combination, and to a method for controlling fungal diseases by applying said fungicidal composition. [Background technology]

[0002] Fungicides are a type of insecticide that are useful in controlling the growth of undesirable fungi and their spores. Profitable crop production depends on effective pest control. Fungicides are an essential and important tool used by farmers to effectively control fungi in order to increase crop yield and quality. The activity of fungicides can be enhanced in various ways to achieve maximum benefit. One way to enhance fungicide activity is to use combinations of fungicides. However, the effectiveness of a particular combination depends on the type of fungus (pest) to be controlled and the type of plant affected by that pest. For example, different pests affect different crops and respond differently to fungicides. Also, the susceptibility of the crops varies depending on the type of fungicide used. As a result, it is difficult to determine the necessary and appropriate fungicide combination, the application rate of the fungicide compositions that make up the fungicide combination, and the ratio of each fungicide in the combination to achieve effective control of fungal diseases and improve crop yield and quality.

[0003] There are many types of fungicides, including multi-site and systemic fungicides. However, as crop resistance decreases, use rates are low and fungal resistance is increasingly seen. Alternative treatment methods with broader disease control, treatment and prevention capabilities, and lower dosage requirements are also needed. Therefore, it is necessary to use fungicide combinations that can overcome one or more of the aforementioned problems.

[0004] Purpose of disclosure A primary object of the present disclosure is to provide a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide.

[0005] It is yet another object of the present disclosure to provide a fungicidal composition comprising at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient.

[0006] It is yet another object of the present disclosure to provide a method for controlling fungal growth comprising applying to said plant a fungicidal combination.

[0007] It is yet another object of the present disclosure to provide a germicidal combination that has improved effectiveness over the individual germicidal agents.

[0008] Yet another object of the present disclosure is to provide a fungicidal combination that provides increased yields in crops to which it is applied.

[0009] Yet another object of the present disclosure is to provide a fungicidal combination that reduces the incidence of fungal diseases in crops to which it is applied. Summary of the Invention

[0010] In one aspect of the disclosure, the disclosure provides a fungicidal combination comprising: (a) at least one quinoline fungicide; and (b) at least one anilinopyrimidine fungicide.

[0011] In another aspect, the present disclosure provides a fungicidal composition comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide; and (c) at least one pesticidally acceptable excipient.

[0012] In another aspect, the disclosure provides the use of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide for controlling the growth of a fungal disease in a plant.

[0013] In yet another aspect, the disclosure provides a method for controlling fungal diseases in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide.

[0014] Additional features and advantages of the present disclosure will become apparent from the following detailed description, which illustrates by way of example the most preferred features of the present disclosure and should not be construed as limiting the scope of the disclosure described herein. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] The present disclosure is described below with reference to the accompanying examples illustrating embodiments of the disclosure. This description is not intended to be a detailed catalog of all the different ways in which the disclosure can be implemented or all the features that can be added to the disclosure. For example, features shown with respect to one embodiment can be incorporated into other embodiments, and features shown with respect to a particular embodiment can be deleted from that embodiment. Thus, the disclosure contemplates that in some embodiments of the disclosure, features or combinations of features described herein can be excluded or omitted. In addition, numerous modifications and additions to the various embodiments suggested herein will be apparent to those skilled in the art in light of the disclosure, and do not depart from the disclosure. Thus, the following description is intended to describe some specific embodiments of the disclosure, and is not intended to exhaustively specify all permutations, combinations, and modifications thereof.

[0016] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of this disclosure, suitable methods and materials are described herein.

[0017] It should be noted that, as used herein, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. As used herein, the terms "first," "second," etc. do not denote a particular order, but are merely used for convenience to denote multiple layers, etc. The terms "preferred" and "preferably" refer to embodiments of the present disclosure that may provide certain advantages under particular circumstances.

[0018] As used herein, the terms "comprising," "including," "having," "containing," "involving," and the like, shall be understood to mean open ended, including but not limited to.

[0019] As used herein, the term "about" or "approximately" means inclusive of the stated value and within an acceptable range of deviation for a particular value as determined by one of ordinary skill in the art, taking into account the measurement in question and the error associated with the measurement of the particular quantity (i.e., limitations of the measurement system). For example, "about" can mean within one or more standard deviations, or within 10% or 5% of a given value.

[0020] Unless otherwise stated herein, the description of a range of values ​​is intended only as a shorthand way to individually cite each value within the range, and each value is incorporated herein as if it were individually stated herein. All range endpoints are included within the range and can be independently combined. All numerical values ​​or numerical ranges used herein include integers within the range and values ​​or fractions of integers within the range, unless the context clearly dictates otherwise. Thus, for example, reference to a range of 90-100% includes 91%, 92%, 93%, 94%, 95%, 95%, 97%, etc., as well as 91.1%, 91.2%, 91.3%, 91.4%, 91.5%, etc., 92.1%, 92.2%, 92.3%, 92.4%, 92.5%, etc. All methods described herein can be performed in any suitable order unless otherwise stated herein or clearly contradicted by context.

[0021] The use of any examples or exemplary language (e.g., "etc.") is merely to better explain the disclosure and does not limit the scope of the disclosure unless specifically claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosure as used herein.

[0022] Although the present disclosure has been described with reference to exemplary embodiments, those skilled in the art will recognize that various modifications can be made and equivalents substituted for elements thereof without departing from the scope of the present disclosure. In addition, many modifications can be made to adapt a particular situation or material to the teachings of the present disclosure without departing from the essential scope of the present disclosure. Therefore, it is not intended that the present disclosure be limited to the particular embodiment disclosed as the best mode contemplated for carrying out the disclosure, but rather, it is intended to include all embodiments falling within the scope of the appended claims.

[0023] As used herein, various amounts expressed as "%" or "% w / v" or "% w / w" refer to the weight percent of the total solution or composition, unless otherwise specified.

[0024] The term "pesticides" as used herein is understood to refer to agricultural chemicals such as pesticides, fungicides, insecticides, acaricides, herbicides, nematicides, plant growth regulators, and the like, and may be used interchangeably.

[0025] As used herein, the term "pesticidally acceptable salt" means a salt that is acceptable for use in agricultural or horticultural applications. The salts referred to herein are pesticidally acceptable salts.

[0026] The term "pesticidal combination" as used herein refers to a mixture in which two or more components are mixed together and intended to be applied, with or without further dilution, to plants.

[0027] As used herein, the term "fungicide" refers to a compound that controls or modifies the growth of fungi.

[0028] As used herein, the term "bactericidal" refers to the ability of a substance to prevent or modify the growth of fungi.

[0029] The term "fungicidal effective amount" as used herein refers to the amount of such a compound or combination of such compounds that can control or modify the growth of fungi. The term "effective amount" or "agriculturally acceptable effective amount" refers to the amount of active ingredients, such as the disclosed combination(s), that adversely affect fungi, treat or prevent fungal disease in plants, and do not cause significant toxicity to the treated plant. Adverse effects include killing (fungicidal) fungi, preventing the growth of fungi, blocking biosynthetic pathway(s), or combinations thereof.

[0030] The term "control" or "disease control" as used herein refers to the treatment and / or prevention of disease, specifically fungal disease. Control effects include any deviation from the natural progression of a disease, such as killing fungi, slowing the progression of a disease, reducing the amount or severity of a fungal disease, etc.

[0031] The term "plant(s)" or "crop(s)" as used herein refers to all physical parts of a plant, such as seeds, seedlings, saplings, roots, tubers, stems, stalks, leaves, fruits, etc. The term also includes crops such as fruits. The term "plant" can also include its propagation material, which can include all reproductive parts of a plant, such as seeds, and vegetative plant material, such as cuttings and tubers, that can be used for plant propagation. This includes seeds, tubers, spores, corms, bulbs, rhizomes, shoots, basal shoots, stolons, buds, and other parts of a plant, including seedlings and young plants that are transplanted after germination or emergence from the soil.

[0032] As used herein, the term "locus" refers to the neighborhood, area, or location where a plant is growing, the location where plant propagation material of a plant is sown, and / or the location where plant propagation material of a plant is planted in soil.

[0033] The term "plant propagation material" as used herein is understood to refer to all reproductive parts of a plant, including seeds, vegetative material such as cuttings and tubers, roots, fruits, tubers, bulbs, rhizomes and other parts of a plant that are transplanted after germination or emerging from the soil, sprouted plants, and / or young plants, which may be protected by a total or partial immersion treatment / system prior to transplantation.

[0034] As used herein, the term "seed" encompasses all types of seeds and plant propagation materials, including, but not limited to, true seeds, seed pieces, suckers, corms, bulbs, fruits, tubers, grains, cuttings, excised shoots, etc. In a preferred embodiment, the seeds are true seeds.

[0035] The term "increased yield" of agricultural crops as used herein means that the yield of the respective plant product is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions without application of the compositions described herein. According to the present disclosure, it is preferred that the application of the combinations and compositions described herein increases the yield of the crop by at least 0.5%, preferably at least 2%, more preferably at least 5%. The compositions also increase the vigor / yield of the plant.

[0036] As used herein, the term "pre-emergence" refers to the time before the plant emerges from the ground. As used herein, the term "post-emergence" refers to the time after the plant emerges from the ground.

[0037] As used herein, the term "g ai / L" refers to the concentration of each active ingredient in "grams" present per "liter" of composition.

[0038] As used herein, the term "g ai / h" refers to the concentration of each active ingredient in "grams" applied "per hectare" of a crop field.

[0039] The term "alkyl" as used herein refers to a linear or branched saturated monovalent hydrocarbon radical containing, for example, one to fifty carbon atoms (C1-C50 alkyl).

[0040] The term "alkylaryl," as used herein, refers to an alkyl group covalently attached to a substituted or unsubstituted aryl group that is bonded to a compound.

[0041] As used herein, the term "aryl" means a cyclic moiety in which all ring members are carbon and at least one ring is aromatic, the moiety having a specified number of carbon atoms, specifically 6 to 24 carbon atoms, more specifically 6 to 12 carbon atoms. Multiple rings may be present and the additional rings may be independently aromatic, saturated or partially unsaturated and may be fused, pendant, spirocyclic, or combinations thereof.

[0042] In another embodiment, each quinoline fungicide acts by different mechanisms, such as affecting plant growth through antioxidant properties, having protective and treatment effects, translocating to the appressorium and inhibiting development to stop infection, and / or other unknown mechanisms. Biological mechanisms of action include inhibition of methionine biosynthesis. Quinoline fungicides include ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol, and salts of quinacetol, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquin, or combinations thereof. Ethoxyquin has the IUPAC name 1,2-dihydro-2,2,4-trimethyl-6-quinolyl ethyl ether. Halacrinate has the IUPAC name 7-bromo-5-chloro-8-quinolyl acrylate. The IUPAC name of ipflufenoquine is 2-{2-[(7,8-difluoro-2-methyl-3-quinolyl)oxy]-6-fluorophenyl}propan-2-ol. The IUPAC name of quinacetol is 5-acetylquinolin-8-ol. The IUPAC name of quinacetol sulfate is sulfate-5-acetylquinolin-8-ol(1 / 2). The IUPAC name of quinofumelin is 3-(4,4-difluoro-3,4-dihydro-3,3-dimethyl-1-isoquinolyl)quinoline. The IUPAC name of quinoxyfen is 5,7-dichloro-4-quinolyl 4-fluorophenyl ether. The IUPAC name of proquinazide is 6-iodo-2-propoxy-3-propylquinazolin-4(3H)-one. The IUPAC name for tebufloquine is 6-tert-butyl-8-fluoro-2,3-dimethyl-4-quinolyl acetate.

[0043] In another embodiment, the anilinopyrimidine fungicide(s) exhibit high activity against a broad range of fungi. The biological mechanism of action includes inhibition of methionine biosynthesis and secretion of hydrolytic enzymes. Anilinopyrimidine fungicides include pyrimethanil, cyprodinil, mepanipyrim, or combinations thereof. Pyrimethanil is a broad spectrum aminopyrimidine fungicide with the IUPAC name N-(4,6-dimethylpyrimidin-2-yl)aniline. Pyrimethanil has a protective effect with some treatment properties. Pyrimethanil inhibits methionine biosynthesis, thus directly affecting protein formation. The IUPAC name for cyprodinil is 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine. The IUPAC name for mepanipyrim is N-(4-methyl-6-prop-1-ynylpyrimidin-2-yl)aniline.

[0044] In another embodiment, it was found that the combination of quinoline fungicide and anilinopyrimidine fungicide improves the effectiveness of each fungicide against fungal pests affecting crops. The incidence and severity of fungal diseases affecting crops is clearly reduced. The disclosed combination advantage was not observed when either quinoline fungicide or anilinopyrimidine fungicide was used alone. Therefore, the unexpected advantage of the present disclosure was due to the combination of quinoline fungicide and anilinopyrimidine fungicide.

[0045] In one embodiment, the present disclosure provides a combination of pesticides.

[0046] Thus, in one embodiment, the present disclosure provides a germicidal combination.

[0047] Thus, in one embodiment, the present disclosure provides a germicidal combination.

[0048] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) providing a fungicidal combination comprising at least one anilinopyrimidine fungicide.

[0049] Quinoline fungicides or other active ingredients, such as anilinopyrimidine fungicides, used throughout this disclosure include their salts, esters, ethers, solvates and polymorphs, including hydrates. Salts include salts that retain the biological effectiveness and properties of the active ingredients and are not biologically or otherwise undesirable, and also include derivatives of the disclosed compounds in which the parent compound is modified by making inorganic and organic non-toxic acid or base addition salts. Salts can be synthesized from the parent compound by conventional chemical methods.

[0050] According to embodiments, the quinoline fungicide is selected from the group consisting of ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol, and salts of quinacetol such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof.

[0051] In a preferred embodiment, the quinoline fungicide is ipflufenoquine.

[0052] According to an embodiment, the anilinopyrimidine fungicide is pyrimethanil, cyprodiamine nil, mepanipyrim, or a combination thereof.

[0053] In a preferred embodiment, the anilinopyrimidine fungicide is pyrimethanil.

[0054] In a preferred embodiment, the anilinopyrimidine fungicide is cyprodinil.

[0055] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The quinoline fungicide is ipflufenoquine, providing a fungicidal combination.

[0056] In one embodiment, the present disclosure provides: (a) ipflufenoquine, and (b) providing a fungicidal combination comprising at least one anilinopyrimidine fungicide.

[0057] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The anilinopyrimidine fungicide provides a fungicidal combination where pyrimethanil is the fungicide.

[0058] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide, and (b) providing a bactericidal combination comprising pyrimethanil;

[0059] In one embodiment, the present disclosure provides: (a) ipflufenoquine, and (b) providing a bactericidal combination comprising pyrimethanil;

[0060] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The anilinopyrimidine fungicide is cyprodinil, providing a fungicidal combination.

[0061] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide, and (b) providing a fungicidal combination comprising cyprodinil;

[0062] In one embodiment, the present disclosure provides: (a) ipflufenoquine, and (b) providing a fungicidal combination comprising cyprodinil;

[0063] In one embodiment, the present disclosure provides: (a) Ethoxyquin, and (b) providing a fungicidal composition comprising pyrimethanil;

[0064] In one embodiment, the present disclosure provides: (a) Halacrinate, and (b) providing a fungicidal composition comprising pyrimethanil;

[0065] In one embodiment, the present disclosure provides: (a) 8-hydroxyquinoline sulfate, and (b) providing a fungicidal composition comprising pyrimethanil;

[0066] In one embodiment, the present disclosure provides: (a) quinacetol, and (b) providing a fungicidal composition comprising pyrimethanil;

[0067] In one embodiment, the present disclosure provides: (a) quinacetol sulfate, and (b) providing a fungicidal composition comprising pyrimethanil;

[0068] In one embodiment, the present disclosure provides: (a) quinofumelin, and (b) providing a fungicidal composition comprising pyrimethanil;

[0069] In one embodiment, the present disclosure provides: (a) quinoxyfen, and (b) providing a fungicidal composition comprising pyrimethanil;

[0070] In one embodiment, the present disclosure provides: (a) proquinazid, and (b) providing a fungicidal composition comprising pyrimethanil;

[0071] In one embodiment, the present disclosure provides: (a) tebufloquine, (b) Pyrimethanil and The present invention provides a disinfecting composition comprising:

[0072] According to embodiments, the quinoline fungicide is present in a concentration ranging from about 1 to about 300 g / L.

[0073] In a preferred embodiment, the quinoline fungicide is present at a concentration ranging from about 1 to about 200 g / L.

[0074] In a preferred embodiment, the quinoline fungicide is present at a concentration ranging from about 10 to about 150 g / L.

[0075] In a preferred embodiment, the quinoline fungicide is present at a concentration ranging from about 10 to about 100 g / L.

[0076] In a preferred embodiment, ipflufenoquine is present at a concentration ranging from about 10 to about 100 g / L.

[0077] In a preferred embodiment, ipflufenoquine is present in a concentration in the range of about 78.65 g / L.

[0078] In a preferred embodiment, ipflufenoquine is present in a concentration in the range of about 69.70 g / L.

[0079] According to embodiments, the anilinopyrimidine fungicide is present at a concentration ranging from about 100 to about 700 g / L.

[0080] In a preferred embodiment, the anilinopyrimidine fungicide is present at a concentration ranging from about 150 to about 650 g / L.

[0081] In a preferred embodiment, the anilinopyrimidine fungicide is present at a concentration ranging from about 200 to about 600 g / L.

[0082] In a preferred embodiment, the anilinopyrimidine fungicide is present at a concentration ranging from about 250 to about 550 g / L.

[0083] In a preferred embodiment, pyrimethanil is present at a concentration ranging from about 250 to about 550 g / L.

[0084] In a preferred embodiment, pyrimethanil is present at a concentration in the range of about 532.62 g / L.

[0085] In a preferred embodiment, cyprodinil is present at a concentration ranging from about 250 to about 550 g / L.

[0086] In a preferred embodiment, cyprodinil is present in a concentration in the range of about 348.40 g / L.

[0087] According to embodiments, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 100:1 to about 1:100.

[0088] In preferred embodiments, the weight ratio of quinoline fungicide to anilinopyrimidine fungicide is selected from ratios including 1:1, 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, and 100:1.

[0089] In preferred embodiments, the weight ratio of quinoline fungicide to anilinopyrimidine fungicide is selected from the ratios consisting of 1:1, 1:10, 1:20, 1:30, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90 and 1:100.

[0090] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 50:1 to about 1:50.

[0091] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 25:1 to about 1:25.

[0092] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 20:1 to about 1:20.

[0093] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 10:1 to about 1:10.

[0094] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is from about 1:4 to about 1:8.

[0095] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is about 1:6.7.

[0096] In a preferred embodiment, the weight ratio of ipflufenoquine to pyrimethanil is about 1:6.7.

[0097] In a preferred embodiment, the weight ratio of the quinoline fungicide to the anilinopyrimidine fungicide is about 1:4.9.

[0098] In a preferred embodiment, the weight ratio of ipflufenoquine to cyprodinil is about 1:4.9.

[0099] Thus, in an embodiment, the present disclosure provides an agrochemical composition.

[0100] Thus, in one embodiment, the present disclosure provides a disinfecting composition.

[0101] Thus, in one embodiment, the present disclosure provides a disinfecting composition.

[0102] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0103] In one embodiment, the quinolone fungicide includes ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol and its salts, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof.

[0104] In a preferred embodiment, the quinoline fungicide is ipflufenoquine.

[0105] In one embodiment, the anilinopyrimidine fungicide comprises pyrimethanil, cyprodinil, mepanipyrim, or a combination thereof.

[0106] In a preferred embodiment, the anilinopyrimidine fungicide is pyrimethanil.

[0107] In a preferred embodiment, the anilinopyrimidine fungicide is cyprodinil.

[0108] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient, wherein the quinoline fungicide is ipflufenoquine;

[0109] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) at least one anilinopyrimidine fungicide, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0110] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) containing at least one pesticidally acceptable excipient; The fungicidal composition provides an anilinopyrimidine fungicide in which pyrimethanil is used.

[0111] In a preferred embodiment, the present disclosure provides (a) at least one quinoline fungicide; (b) pyrimethanil, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0112] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) pyrimethanil, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0113] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) containing at least one pesticidally acceptable excipient; A fungicidal composition is provided, wherein the anilinopyrimidine fungicide is cyprodinil.

[0114] In a preferred embodiment, the present disclosure provides (a) at least one quinoline fungicide; (b) cyprodinil, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0115] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) cyprodinil, and (c) providing a fungicidal composition comprising at least one pesticidally acceptable excipient;

[0116] In one embodiment, the pesticidally acceptable excipient is one or more selected from dispersants, carriers, emulsifiers, colorants, thickeners, binders, antifreeze agents, antifoam agents, antioxidants, solvents, preservatives, diluents, other adjuvants, or combinations thereof.

[0117] In another embodiment, the dispersing agent includes anionic surfactants such as alkyl sulfate salts, alkylaryl sulfonates, dialkyl sulfosuccinate salts, polyoxyethylene alkylaryl ether phosphate salts, lignosulfonates, naphthalenesulfonic acid formaldehyde polycondensates, sodium salts of naphthalenesulfonic acid condensates, and nonionic surfactants such as polyoxyethylene alkylaryl ethers, polyoxyethylene alkyl polyoxypropylene block copolymers, sorbitan fatty acid esters, and cationic surfactants such as alkyltrimethylammonium salts.

[0118] Other examples include acrylic copolymer solutions, polyalkylene oxide block copolymers, and combinations thereof.

[0119] In another embodiment, the carrier includes minerals such as kaolin clay, attapulgite clay, bentonite, montmorillonite, acid clay, pyrophyllite, talc, diatomaceous earth, calcite, natural organics such as corn cob flour, walnut shell flour, synthetic organics such as urea, salts such as calcium carbonate, ammonium sulfate, synthetic inorganics such as synthetic hydrated silicon oxide, etc. Examples of liquid carriers include aromatic hydrocarbons such as xylene, alkylbenzene, methylnaphthalene, alcohols such as 2-propanol, ethylene glycol, propylene glycol, ethylene glycol monoethyl ether, ketones such as acetone, cyclohexanone, isophorone, vegetable oils such as soybean oil, cottonseed oil, petroleum aliphatic hydrocarbons, esters, dimethyl sulfoxide, acetonitrile, and water.

[0120] In another embodiment, emulsifiers that can be advantageously used herein can be readily determined by one skilled in the art and include various nonionic, anionic, cationic, and amphoteric emulsifiers, or mixtures of two or more emulsifiers. Examples of nonionic emulsifiers useful for preparing emulsifiable concentrates include polyalkylene glycol ethers, and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines, or fatty acids with ethoxylated alkylphenols and carboxylic acid esters solubilized with ethylene oxide, propylene oxide, e.g., polyols or polyoxyalkylenes. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts or sulfated polyglycol ethers, and suitable salts of phosphorylated polyglycol ethers. Other examples include tristyrylphenol ethoxylates, linear calcium alkylbenzene sulfonates, castor oil ethoxylates, and combinations thereof.

[0121] In one embodiment, the colorant may be selected from iron oxide, titanium oxide, Prussian blue, and organic dyes such as alizarin dyes, azo dyes, or metal phthalocyanine dyes, and trace elements such as salts of iron, manganese, boron, copper, cobalt, molybdenum, and zinc.

[0122] In one embodiment, the thickener / binder / gelling agent may be selected from, but is not limited to, molasses, granulated sugar, alginates, karaya gum, jaggery gum, tragacanth gum, polysaccharide gums, mucilages, xanthan gum, or combinations thereof. In another embodiment, the binder is a silicate such as magnesium aluminum silicate, polyvinyl acetate, polyvinyl acetate copolymers, polyvinyl alcohol, polyvinyl alcohol copolymers, cellulose including ethyl cellulose and methyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxymethyl propyl cellulose, polyvinyl pyrrolidone, dextrin, maltodextrin, polysaccharides, fats, oils, proteins, gum arabic, shellac, vinylidene chloride, vinylidene chloride copolymers, calcium lignosulfonate, acrylic copolymers, starch, polyvinyl acrylate, zein, gelatin. , carboxymethylcellulose, chitosan, polyethylene oxide, acrylimide polymers and copolymers, polyhydroxyethyl acrylate, methylacrylimide monomer, alginates, ethylcellulose, polychloroprene and syrups or mixtures thereof; polymers and copolymers of vinyl acetate, methylcellulose, vinylidene chloride, acrylics, cellulose, polyvinylpyrrolidone, polysaccharides; polymers and copolymers of vinylidene chloride and vinyl acetate-ethylene copolymers; combinations of polyvinyl alcohol and sucrose; and plasticizers such as glycerol, propylene glycol, polyglycols.

[0123] In another embodiment, the antifreeze agent(s) added to the composition may be an alcohol selected from the group consisting of ethylene glycol, propylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,4-pentanediol, 3-methyl-1,5-pentanediol, 2,3-dimethyl-2,3-butanediol, trimethylolpropane, mannitol, sorbitol, glycerol, pentaerythritol, 1,4-cyclohexanedimethanol, xylenol, bisphenols such as bisphenol A, and the like. Additionally, there are ether alcohols such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyoxyethylene or polyoxypropylene glycol having a molecular weight up to about 4000; diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, triethylene glycol monomethyl ether, butoxyethanol, butylene glycol monobutyl ether, dipentaerythritol, tripentaerythritol, tetrapentaerythritol, diglycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, heptaglycerol, octaglycerol, and the like.

[0124] According to one embodiment, the antifoaming agent may be selected from polydimethoxysiloxanes, polydimethylsiloxanes, dimethylsiloxane polymers, siloxane polyalkylene oxide copolymers, polypropylene glycols, alkyl polyacrylates, castor oil, fatty acids, fatty acid esters, fatty acid sulfates, fatty alcohols, fatty alcohol esters, fatty alcohol sulfates, olive oil, mono- and diglycerides, paraffin oils, paraffin waxes, polypropylene glycols, silicone oils, vegetable fats, vegetable fat sulfates, vegetable oils, vegetable oil sulfates, vegetable waxes, vegetable wax sulfates, agents based on silicon or magnesium stearate.

[0125] In another embodiment, the antioxidant is, for example, an amino acid (e.g., glycine, histidine, tyrosine, tryptophan) and its derivatives, imidazole and imidazole derivatives (e.g., urocanic acid), peptides (e.g., D,L-carnosine, D-carnosine, L-carnosine and its derivatives (e.g., anserine), carotenoids, carotenes (e.g., α-carotene, β-carotene, lycopene) and its derivatives, lipoic acid and its derivatives (e.g., dihydrolipoic acid), aurothioglucose, propylthiouracil, and further thio compounds. (e.g., thioglycerol, thiosorbitol, thioglycolic acid, thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl, lauryl, palmitoyl, oleyl, gamma-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts), and very poorly tolerated doses. Sulfoximine compounds (e.g., buthionine sulfoximine, homocysteine ​​sulfoximine, buthionine sulfone, penta-, hexa-, and heptathionine sulfoximine) in concentrations of (e.g., pmol / kg to pmol / kg), as well as metal chelators (e.g., α-hydroxy fatty acids, EDTA, EGTA, phytic acid, lactoferrin), α-hydroxy acids (e.g., citric acid, lactic acid, malic acid), humic acid, bile acids, bile extracts, gallic acid esters (e.g., propyl, octyl, and dodecyl gallates), flavonoids, catechins, bilirubin, bilirubin, and bisphosphonates. Verdin and its derivatives, unsaturated fatty acids and their derivatives (e.g., gamma-linolenic acid, linoleic acid, arachidonic acid, oleic acid), folic acid and its derivatives, hydroquinone and its derivatives (e.g., arbutin), ubiquinone, ubiquinol and its derivatives, vitamin C and its derivatives (e.g., ascorbyl palmitate, ascorbyl stearate, ascorbyl dipalmitate, ascorbyl acetate, magnesium ascorbyl phosphate, sodium and magnesium ascorbate, disodium ascorbyl phosphate and ascorbyl sulfate,Tocopherol and its derivatives (e.g., tocopherol acetate, tocopherol linoleate, tocopherol oleate and tocopherol succinate, tocophereth-5, tocophereth-10, tocophereth-12, tocophereth-18, tocophereth-50, tocophersolan), Vitamin A and its derivatives (e.g., Vitamin A palmitate), Coniferyl benzoate of benzoin resin, Rutin, Rutinic acid and its derivatives, Rutinyl disulfate disodium, cinnamic acid and its derivatives (e.g. ferulic acid, ethyl ferulic acid, caffeic acid), kojic acid, chitosan glycolate and salicylate, butyl hydroxytoluene, butyl hydroxyanisole, nordihydroguaiaic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, selenium and selenium derivatives (e.g. selenomethionine), stilbene and stilbene derivatives (e.g. stilbene oxide, trans stilbene oxide). According to the present disclosure, suitable derivatives (salts, esters, sugars, nucleotides, nucleosides, peptides, and lipids) and mixtures of these specific active ingredients, or plant extracts containing these antioxidants (e.g. tea tree oil, rosemary extract, and rosmarinic acid) can be used. In general, mixtures of the aforementioned antioxidants are possible.

[0126] According to an embodiment, examples of suitable solvents are water, vegetable oil, cyclohexanone, 2-butoxyethanol or derivatives thereof. In principle, solvent mixtures can also be used.

[0127] In another embodiment, suitable preservatives are, for example, benzothiazole, 1,2-benzisothiazolin-3-one, sodium dichloro-s-triazinetrione, sodium benzoate, potassium sorbate, 1,2-phenylisothiazolin-3-one, 2-bromo-2-nitro-1,3-propanediol, interchloroxylenol paraoxybenzoate butyl, and benzoic acid, and combinations thereof.

[0128] According to an embodiment, an example of a suitable diluent is water.

[0129] According to embodiments, examples of other auxiliary agents that may be included in the composition may include water-soluble polymers such as polyvinyl alcohol and polyvinylpyrrolidone, polysaccharides such as gum arabic, alginic acid or salts thereof, inorganic substances such as carboxymethylcellulose (CMC), xanthan gum, aluminum magnesium silicate and alumina sol, preservatives, colorants and stabilizers, for example, isopropyl acid phosphate (PAP), butylated hydroxytoluene (BHT), etc.

[0130] In a preferred embodiment, the fungicidal composition comprises from about 0.1% w / w to about 70% w / w of a quinoline fungicide by total weight of the composition.

[0131] In a preferred embodiment, the fungicidal composition comprises from about 1% w / w to about 60% w / w of a quinoline fungicide by total weight of the composition.

[0132] In a preferred embodiment, the fungicidal composition comprises from about 1% w / w to about 50% w / w of a quinoline fungicide by total weight of the composition.

[0133] In a preferred embodiment, the fungicidal composition comprises from about 1% w / w to about 30% w / w of a quinoline fungicide by total weight of the composition.

[0134] In a preferred embodiment, the fungicidal composition comprises about 7.15% w / w of a quinoline fungicide by total weight of the composition.

[0135] In a preferred embodiment, the antiseptic composition comprises about 7.15% w / w of ipflufenoquine by total weight of the composition.

[0136] In a preferred embodiment, the fungicidal composition comprises about 6.69% w / w of a quinoline fungicide by total weight of the composition.

[0137] In a preferred embodiment, the antiseptic composition comprises about 6.69% w / w of ipflufenoquine by total weight of the composition.

[0138] According to embodiments, the fungicidal composition comprises from about 1% w / w to about 70% w / w of anilinopyrimidine fungicide by total weight of the composition.

[0139] In a preferred embodiment, the fungicidal composition comprises from about 1% w / w to about 60% w / w of an anilinopyrimidine fungicide by total weight of the composition.

[0140] In a preferred embodiment, the fungicidal composition comprises from about 10% w / w to about 50% w / w of an anilinopyrimidine fungicide by total weight of the composition.

[0141] In a preferred embodiment, the fungicidal composition comprises from about 20% w / w to about 50% w / w of anilinopyrimidine fungicide by total weight of the composition.

[0142] In a preferred embodiment, the fungicidal composition comprises about 48.42% w / w of anilinopyrimidine fungicide by total weight of the composition.

[0143] In a preferred embodiment, the antiseptic composition comprises about 48.42% w / w pyrimethanil by total weight of the composition.

[0144] In a preferred embodiment, the fungicidal composition comprises about 34.04% w / w of anilinopyrimidine fungicide by total weight of the composition.

[0145] In a preferred embodiment, the antiseptic composition comprises about 34.04% w / w cyprodinil by total weight of the composition.

[0146] According to an embodiment, the fungicidal composition comprises from about 1% w / w to about 30% w / w of an agriculturally acceptable excipient by total weight of the composition.

[0147] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) from about 1% w / w to about 30% w / w of at least one quinoline fungicide; (b) about 20% w / w to about 50% w / w of at least one anilinopyrimidine fungicide, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0148] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 60% w / w of ipflufenoquin; (b) about 1% w / w to about 60% w / w of pyrimethanil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0149] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 60% w / w of ipflufenoquin; (b) about 1% w / w to about 60% w / w of cyprodinil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0150] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 50% w / w of ipflufenoquin, (b) about 10% w / w to about 50% w / w of pyrimethanil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0151] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 50% w / w of ipflufenoquin, (b) about 10% w / w to about 50% w / w of cyprodinil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0152] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 30% w / w of ipflufenoquin; (b) about 20% w / w to about 50% w / w of pyrimethanil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0153] In a preferred embodiment, the present disclosure provides (a) about 1% w / w to about 30% w / w of ipflufenoquin; (b) about 20% w / w to about 50% w / w of cyprodinil, and (c) providing a fungicidal composition comprising from about 1% w / w to about 30% w / w of at least one pesticidally acceptable excipient;

[0154] In one embodiment, the composition of the present disclosure is produced by combining the active ingredient with at least one pesticidally acceptable excipient to prepare a mixture, and then formulating the mixture into a solid or liquid formulation. Examples of solid or liquid formulations include, but are not limited to, wettable powders, granules, dusts, soluble (liquid) concentrates, suspension concentrates (SC), oil-in-water emulsions (EW), water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC (combined capsule suspension and suspension concentrate formulations), oil dispersions, other known formulation types, or combinations thereof.

[0155] In one embodiment, the present disclosure provides: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) containing at least one pesticidally acceptable excipient; The antiseptic composition is provided in the form of a liquid formulation.

[0156] In one embodiment, the liquid formulation is selected from a capsule suspension (CS), a dispersible concentrate (DC), an emulsion, water in oil (EO), an emulsion, oil in water (EW), an oil dispersion (OD), an oil miscible flowable concentrate (oil miscible suspension (OF), an oil miscible liquid (OL), a suspension concentrate (SC), a soluble concentrate (SL), or a suspoemulsion (SE).

[0157] In a preferred embodiment, the liquid formulation is an emulsion, oil-in-water (EW).

[0158] In a preferred embodiment, the liquid formulation is a suspension concentrate (SC).

[0159] According to an embodiment, the present disclosure provides a method for manufacturing a semiconductor device comprising: (a) at least one quinoline fungicide, and (b) providing a liquid formulation fungicidal combination comprising at least one anilinopyrimidine fungicide.

[0160] According to an embodiment, the present disclosure provides a method for manufacturing a semiconductor device comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) providing a liquid formulated fungicidal composition comprising at least one pesticidally acceptable excipient;

[0161] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) pyrimethanil, and (c) providing a liquid formulated fungicidal composition comprising at least one pesticidally acceptable excipient;

[0162] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) cyprodinil, and (c) providing a liquid formulated fungicidal composition comprising at least one pesticidally acceptable excipient;

[0163] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) Ipflufenoquine, (b) pyrimethanil, and (c) providing a suspension concentrate (SC) fungicidal composition comprising at least one pesticidally acceptable excipient;

[0164] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) Ipflufenoquine, (b) cyprodinil, and (c) providing an emulsion water-in-oil (EW) fungicidal composition comprising at least one pesticidally acceptable excipient;

[0165] According to one embodiment, the present disclosure provides a method for producing a method for manufacturing a semiconductor device comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) containing at least one pesticidally acceptable excipient; The germicidal compositions are provided in the form of tank mix or premix / ready mix formulations.

[0166] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) pyrimethanil, and (c) containing at least one pesticidally acceptable excipient; The germicidal compositions are provided in the form of tank mix or premix / ready mix formulations.

[0167] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) cyprodinil, and (c) containing at least one pesticidally acceptable excipient; The germicidal compositions are provided in the form of tank mix or premix / ready mix formulations.

[0168] According to embodiments, the present disclosure provides a disinfectant composition in the form of a tank-mix formulation.

[0169] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquin (b) pyrimethanil, and (c) providing a tank-mix fungicidal composition comprising at least one pesticidally acceptable excipient;

[0170] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) cyprodinil, and (c) providing a tank-mix fungicidal composition comprising at least one pesticidally acceptable excipient;

[0171] According to embodiments, the present disclosure provides a disinfecting composition in the form of a premix / ready-mix formulation.

[0172] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) pyrimethanil, and (c) providing a premix fungicidal composition comprising at least one pesticidally acceptable excipient;

[0173] In a preferred embodiment, the present disclosure provides (a) Ipflufenoquine, (b) cyprodinil, and (c) providing a premix fungicidal composition comprising at least one pesticidally acceptable excipient;

[0174] In another embodiment, the fungicidal combinations disclosed herein may be applied simultaneously as a tank mix, or together as a premix formulation, or each fungicide may be applied sequentially.

[0175] In yet another embodiment, the fungicidal composition may be applied to the soil either before plant emergence (pre-emergence), before planting or after planting. Alternatively, application of the fungicidal composition may be a post-emergence application (post-emergence).

[0176] In yet another embodiment, the fungicidal combination may be applied at different times during crop development, either as an early application (pre-emergence) or late post-emergence as a foliar spray.

[0177] According to an embodiment, the present disclosure provides the use of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide for controlling the growth of fungal diseases in plants.

[0178] According to an embodiment, the present disclosure provides for the use of a fungicidal combination to control the growth of fungi, wherein the fungicidal combination comprises: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide.

[0179] In another embodiment, the disclosure provides for the use of a fungicidal combination to control the growth of a fungal disease, wherein the fungicidal combination comprises: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide.

[0180] In a preferred embodiment, the present disclosure provides for the use of a fungicidal combination to control the growth of fungi, wherein the fungicidal combination comprises: (a) ipflufenoquine, and (b) Contains pyrimethanil.

[0181] In a preferred embodiment, the present disclosure provides for the use of a fungicidal combination to control the growth of a fungal disease, wherein the fungicidal combination comprises: (a) ipflufenoquine, and (b) Contains pyrimethanil.

[0182] In a preferred embodiment, the present disclosure provides for the use of a fungicidal combination to control the growth of a fungal disease, wherein the fungicidal combination comprises: (a) ipflufenoquine, and (b) Contains cyprodinil.

[0183] In a preferred embodiment, the present disclosure provides for the use of a fungicidal combination to control the growth of a fungal disease, wherein the fungicidal combination comprises: (a) ipflufenoquine, and (b) Contains cyprodinil.

[0184] According to an embodiment, the present disclosure provides for the use of a fungicidal composition for controlling the growth of a fungal disease, wherein the fungicidal composition comprises: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) Contains at least one pesticidally acceptable excipient.

[0185] According to an embodiment, the present disclosure provides for the use of a fungicidal composition for controlling the growth of a fungal disease, wherein the fungicidal composition comprises: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) Contains at least one pesticidally acceptable excipient.

[0186] In a preferred embodiment, the present disclosure provides for the use of a fungicidal composition to control the growth of fungi, wherein the fungicidal composition comprises: (a) Ipflufenoquine, (b) pyrimethanil, and (c) Contains at least one pesticidally acceptable excipient.

[0187] In a preferred embodiment, the present disclosure provides for the use of a fungicidal composition to control the growth of a fungal disease, wherein the fungicidal composition comprises: (a) Ipflufenoquine, (b) pyrimethanil, and (c) Contains at least one pesticidally acceptable excipient.

[0188] In a preferred embodiment, the present disclosure provides for the use of a fungicidal composition to control the growth of fungi, wherein the fungicidal composition comprises: (a) Ipflufenoquine, (b) cyprodinil, and (c) Contains at least one pesticidally acceptable excipient.

[0189] In a preferred embodiment, the present disclosure provides for the use of a fungicidal composition to control the growth of a fungal disease, wherein the fungicidal composition comprises: (a) Ipflufenoquine, (b) cyprodinil, and (c) Contains at least one pesticidally acceptable excipient.

[0190] In another embodiment, the fungicidal combination and / or composition may be applied before or after the plant or its propagation material is infected with a fungus.

[0191] In another embodiment, the fungicidal combinations and compositions are applied to the foliage, ground or plant. It may be used for application to an object or a locus or to plant propagation material, or a combination thereof.

[0192] According to an embodiment, the present disclosure provides a process for preparing a germicidal combination, the germicidal combination comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide.

[0193] In a preferred embodiment, the present disclosure provides a process for preparing a germicidal combination, the germicidal combination comprising: (a) ipflufenoquine, and (b) Contains pyrimethanil.

[0194] In a preferred embodiment, the present disclosure provides a process for preparing a germicidal combination, wherein the germicidal combination comprises: (a) ipflufenoquine, and (b) Contains cyprodinil.

[0195] According to an embodiment, the present disclosure provides a process for preparing a germicidal composition, wherein the germicidal composition comprises: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) Contains at least one pesticidally acceptable excipient.

[0196] In a preferred embodiment, the present disclosure provides a process for preparing a germicidal composition, the germicidal composition comprising: (a) Ipflufenoquine, (b) pyrimethanil, and (c) Contains at least one pesticidally acceptable excipient.

[0197] In a preferred embodiment, the present disclosure provides a process for preparing a germicidal composition, the germicidal composition comprising: (a) Ipflufenoquine, (b) cyprodinil, and (c) Contains at least one pesticidally acceptable excipient.

[0198] According to an embodiment, the process for preparing the bactericidal combination comprises: adding and mixing at least one quinoline fungicide and at least one anilinopyrimidine fungicide to obtain a fungicidal combination.

[0199] In a preferred embodiment, the process for preparing the bactericidal combination comprises: adding and mixing ipflufenoquine and pyrimethanil to obtain the bactericidal combination.

[0200] In a preferred embodiment, the process for preparing the bactericidal combination comprises: adding and mixing ipflufenoquine, pyrimethanil, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0201] In a preferred embodiment, the process for preparing the antiseptic composition comprises: adding and mixing at least one quinoline fungicide and at least one anilinopyrimidine fungicide to obtain a fungicidal combination.

[0202] In a preferred embodiment, the process for preparing the antiseptic composition comprises: adding and mixing ipflufenoquine and cyprodinil to obtain a fungicidal composition.

[0203] According to an embodiment, the process for preparing a disinfecting composition comprises: adding and mixing ipflufenoquine, cyprodinil and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0204] According to an embodiment, a process for preparing a liquid formulation germicidal composition comprises: adding and mixing at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0205] In a preferred embodiment, the process for preparing a liquid formulation germicidal composition comprises: adding and mixing ipflufenoquine, pyrimethanil and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0206] In a preferred embodiment, the process for preparing a liquid formulation germicidal composition comprises: adding and mixing ipflufenoquine, cyprodinil and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0207] According to an embodiment, a process for preparing a premixed disinfectant composition comprises: adding and mixing at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0208] In a preferred embodiment, the process for preparing a premixed disinfectant composition comprises: adding and mixing ipflufenoquine, pyrimethanil, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0209] In a preferred embodiment, the process for preparing a premixed disinfectant composition comprises: adding and mixing ipflufenoquine, cyprodinil, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0210] According to an embodiment, a process for preparing a suspension concentrate (SC) germicidal composition comprises: adding and mixing at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0211] In a preferred embodiment, the process for preparing a suspension concentrate (SC) germicidal composition comprises: adding and mixing ipflufenoquine, pyrimethanil, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0212] According to an embodiment, a process for preparing an emulsion, oil-in-water (EW) germicidal composition comprises: adding and mixing at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0213] In a preferred embodiment, the process for preparing an emulsion, oil-in-water (EW) germicidal composition comprises: adding and mixing ipflufenoquine, cyprodinil and at least one pesticidally acceptable excipient to obtain a fungicidal composition.

[0214] According to embodiments, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide.

[0215] According to embodiments, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide.

[0216] In a preferred embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising ipflufenoquine and pyrimethanil.

[0217] In a preferred embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising ipflufenoquine and pyrimethanil.

[0218] In a preferred embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising ipflufenoquine and cyprodinil.

[0219] In a preferred embodiment, the present disclosure provides a method for controlling fungal growth in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising ipflufenoquine and cyprodinil.

[0220] According to embodiments, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient.

[0221] According to embodiments, the present disclosure provides a method for controlling fungal growth in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient.

[0222] In a preferred embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising ipflufenoquine, pyrimethanil, and at least one pesticidally acceptable excipient.

[0223] In a preferred embodiment, the present disclosure provides a method for controlling fungal growth in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising ipflufenoquine, pyrimethanil, and at least one pesticidally acceptable excipient.

[0224] In a preferred embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising ipflufenoquine, cyprodinil, and at least one pesticidally acceptable excipient.

[0225] In a preferred embodiment, the disclosure provides a method for controlling fungal growth in a plant comprising applying to the plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising ipflufenoquine, cyprodinil, and at least one pesticidally acceptable excipient.

[0226] According to another embodiment, examples of trees and plants include apples, almonds, grapes, and stone fruits.

[0227] In a preferred embodiment, the stone fruit comprises a peach.

[0228] In a preferred embodiment, apple trees (apple crops) are cultivated worldwide and their fruits are edible and widely consumed. Apple crops are affected by fungi such as Venturia inaequalis, Podosfera leucotricha, Diplocarpon mali, Botryosphaeria obtusa, Botryosphaeria dosidea, and Colletotrichum spp.

[0229] In a preferred embodiment, almond trees (almond crops) are also widely cultivated around the world. Almond crops are affected by fungi such as, but not limited to, Monilia species. Examples include Monilia laxa, Monilia fructigena, and Monilia fructicola.

[0230] In another preferred embodiment, grape is a commercially important crop in many countries of the world. The main producing countries of grape are Italy, France, Spain, the United States, Turkey, China, and Argentina. Pests affecting grape crops include, but are not limited to, Venturia inaequalis, Diplocarpon mali, Botryosphaeria obtusa, Podosfera leucotricha, and Alternaria mali.

[0231] In another preferred embodiment, peach trees are grown in both the Northern and Southern Hemispheres.The main pests of peaches include, but are not limited to, Alternaria alternata, Monilinia fruticola, Monilinia rachis, Armillaria mellifera, Cercospora circumcisa, etc.

[0232] According to an embodiment, the present disclosure provides a method for controlling the growth of fungal diseases in crops including apples, almonds, or stone fruits, the method comprising: (a) at least one quinoline fungicide, and (b) applying to the article, or to the locus or plant propagation material thereof, an effective amount of a fungicidal combination comprising at least one anilinopyrimidine fungicide.

[0233] In a preferred embodiment, the stone fruit crop is a peach.

[0234] According to an embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a crop, including apple, almond, or stone fruit, comprising: (a) ipflufenoquine, and (b) applying to the crop, or to the locus or plant propagation material thereof, an effective amount of a fungicidal combination comprising pyrimethanil.

[0235] According to one embodiment, the present disclosure provides a method for controlling the growth of fungal diseases in crops including apples, almonds, or stone fruits, the method comprising: (a) ipflufenoquine, and (b) applying to the crop, or to the locus or plant propagation material thereof, an effective amount of a fungicidal combination comprising cyprodinil.

[0236] According to one embodiment, the present disclosure provides a method for controlling the growth of fungal diseases in crops including apples, almonds, or stone fruits, the method comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) applying to the crop, or to the locus or plant propagation material thereof, an effective amount of a fungicidal composition, which comprises at least one pesticidally acceptable excipient.

[0237] In a preferred embodiment, the stone fruit crop is a peach.

[0238] According to an embodiment, the present disclosure provides a method for controlling the growth of fungal diseases in crops including apples, almonds, or stone fruits, the method comprising: (a) Ipflufenoquine, (b) pyrimethanil, and (c) applying to the crop, or the locus thereof, or the plant propagation material an effective amount of a fungicidal composition, which comprises at least one pesticidally acceptable excipient.

[0239] According to an embodiment, the present disclosure provides a method for controlling the growth of fungal diseases in crops including apples, almonds, or stone fruits, the method comprising: (a) Ipflufenoquine, (b) cyprodinil, and (c) applying to the crop, or the locus thereof, or the plant propagation material an effective amount of a fungicidal composition, which comprises at least one pesticidally acceptable excipient.

[0240] In yet another embodiment, the disclosure provides a method for controlling the growth of fungal diseases comprising applying a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide, wherein the fungicidal combination is applied in a range of from about 10 gai. / ha to about 500 gai. / ha.

[0241] In a preferred embodiment, the disclosure provides a method for controlling the growth of fungal diseases comprising applying a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide, wherein the fungicidal combination is applied in a range of from about 50 gai. / ha to about 450 gai. / ha.

[0242] In a preferred embodiment, the present invention provides a method for controlling the growth of fungal diseases comprising applying a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide, wherein the fungicidal combination is applied in a range of from about 100 gai. / ha to about 400 gai. / ha.

[0243] In a preferred embodiment, the present invention provides a method for controlling the growth of fungal diseases comprising applying a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide, wherein the fungicidal combination is applied in a range of from about 250 gai. / ha to about 360 gai. / ha.

[0244] In a preferred embodiment, the disclosure provides a method for controlling the growth of fungal diseases comprising applying a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide, wherein the fungicidal combination is applied in the range of about 0.25 kg ai / ha to about 0.36 g ai / ha.

[0245] According to embodiments of the present disclosure, the various components of the germicidal combination can be prepared individually or already partially or completely mixed with at least one other component to prepare a combination according to the present disclosure, which can also be packaged and further used as a combination configuration, such as a kit of parts.

[0246] The disclosure also provides kits that include the fungicidal combination and instructions for controlling fungal growth or the growth of a fungal disease. The instructions typically include instructions for applying the fungicidal combination to a plant, or to a locus or plant propagation material thereof.

[0247] According to an embodiment, the kit of parts comprises: a) at least one quinoline fungicide; b) at least one anilinopyrimidine fungicide, and c) containing at least one pesticidally acceptable excipient; Also, as an option, d) further comprising instructions for use.

[0248] In one embodiment of the present disclosure, the kit may include one or more components that include all the components that can be used to prepare a germicidal combination, for example, the kit may include active ingredients and / or pesticidally acceptable excipients. One or more components may be combined or pre-formulated. In embodiments where two or more components are provided in the kit, the components may already be combined and thus packaged in a single container, such as a vial, bottle, can, pouch, bag, or canister. In other embodiments, two or more components of the kit are packaged separately, i.e., not pre-formulated. Thus, the kit includes one or more separate containers, such as a vial, can, bottle, pouch, bag, or canister, each container containing a separate component for the germicidal combination.

[0249] In either form, the components of the kit may be applied separately from additional components, or together with additional components, or as components of a formulation according to the disclosure to prepare a bactericidal combination according to the disclosure.

[0250] In another embodiment, the above disinfecting combination is stable over time and at various temperatures.

[0251] All of the features described in this specification can be combined with any of the above aspects in any combination.

[0252] According to an embodiment, it has been found that a certain weight ratio of the quinoline fungicide and the anilinopyrimidine fungicide can produce a synergistic effect. Thus, a further aspect of the present disclosure is a composition in which the quinoline fungicide and the anilinopyrimidine fungicide are present in an amount that produces a synergistic effect. This synergistic effect is evident from the fact that the fungicidal effect of a composition that includes both a quinoline fungicide and an anilinopyrimidine fungicide is greater than the sum of the fungicidal effects of the quinoline fungicide and the anilinopyrimidine fungicide individually. The fungicidal effect of the combination can be seen from the following examples. Although the individual active compounds show lower activity in terms of fungicidal effect, certain combinations have a fungicidal effect that exceeds the expected efficacy. These combinations or compositions above can be used in synergistic amounts. From the following examples, it can be seen that the fungicidal action of the combination according to the present disclosure exceeds the calculated value, i.e., the fungicidal combination has a synergistic effect of suppressing the growth of fungal diseases in plants.

[0253] In yet another embodiment, whether a combination is synergistic is determined by comparing the observed efficacy of the bactericidal combination to the expected efficacy of the bactericidal combination, as calculated by the Colby formula.

[0254] In the Colby formula shown below, E is the expected efficacy of the quinoline and anilinopyrimidine fungicide combination, X is the observed efficacy of the quinoline fungicide, and Y is the observed efficacy of the anilinopyrimidine fungicide. The observed efficacy values ​​(X and Y) are the percent disease control (e.g., percent reduction in fungal disease severity) of the quinoline and anilinopyrimidine fungicides used alone. If the observed efficacy of the quinoline and anilinopyrimidine fungicide combination is greater than the expected efficacy, the combination is deemed synergistic. If the observed efficacy is equal to or less than the expected efficacy, the combination is deemed not synergistic.

[0255] Colby's equation is E=X+Y-XY / 100.

[0256] In one embodiment, the present disclosure provides a synergistic combination of pesticides.

[0257] Thus, in one embodiment, the present disclosure provides a synergistic bactericidal combination.

[0258] Thus, in one embodiment, the present disclosure provides a synergistic bactericidal combination.

[0259] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) providing a synergistic fungicidal combination comprising at least one anilinopyrimidine fungicide;

[0260] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The quinoline and anilinopyrimidine fungicides are present in a ratio of 1:6.7, providing a synergistic fungicidal combination.

[0261] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The quinoline and anilinopyrimidine fungicides are present in a ratio of 1:4.9, providing a synergistic fungicidal combination.

[0262] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The quinoline fungicide and the anilinopyrimidine fungicide are present in a synergistic ratio of 1:6.7, providing a synergistic fungicidal combination.

[0263] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; The quinoline fungicide and the anilinopyrimidine fungicide are present in a synergistic ratio of 1:4.9, providing a synergistic fungicidal combination.

[0264] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) providing a synergistic fungicidal combination comprising at least one anilinopyrimidine fungicide;

[0265] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) providing a synergistic bactericidal combination that includes pyrimethanil;

[0266] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) providing a synergistic fungicidal combination that includes cyprodinil;

[0267] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) providing a synergistic bactericidal combination that includes pyrimethanil;

[0268] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) providing a synergistic fungicidal combination that includes cyprodinil;

[0269] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) containing pyrimethanil, Ipflufenoquine and pyrimethanil are present in a ratio of 1:6.7 and provide a synergistic bactericidal combination.

[0270] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) containing pyrimethanil, Ipflufenoquine and pyrimethanil exist in a synergistic ratio of 1:6.7, providing a synergistic bactericidal combination.

[0271] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) containing cyprodinil, Iflufenoquine and cyprodinil are present in a ratio of 1:4.9 and provide a synergistic bactericidal combination.

[0272] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) ipfufenoquine, and (b) containing cyprodinil, Iflufenoquine and cyprodinil exist in a synergistic ratio of 1:4.9, providing a synergistic bactericidal combination.

[0273] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0274] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) Ipflufenoquine, (b) at least one anilinopyrimidine fungicide, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0275] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide; (b) pyrimethanil, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0276] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide; (b) cyprodinil, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0277] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) Ipflufenoquine, (b) pyrimethanil, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0278] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) Ipflufenoquine, (b) cyprodinil, and (c) providing a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient;

[0279] Thus, in one embodiment the disclosure provides the use of a synergistic fungicidal combination for controlling the growth of a fungal disease in a plant, the combination comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide.

[0280] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: A process for preparing a synergistic fungicidal combination is provided, comprising adding and mixing at least one quinoline fungicide and at least one anilinopyrimidine fungicide to form a mixture and obtain a fungicidal combination.

[0281] Thus, in one embodiment, the present disclosure provides a method for producing a method for treating a cancer cell comprising: (a) at least one quinoline fungicide, and (b) providing a method for controlling the growth of a fungal disease in a plant, the method comprising applying to the plant, its locus, or plant propagation material an effective amount of a synergistic fungicidal combination comprising at least one anilinopyrimidine fungicide.

[0282] Thus, in one embodiment, the present disclosure provides for the use of a synergistic fungicidal composition for controlling the growth of a fungal disease in a plant, the composition comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) Contains at least one pesticidally acceptable excipient.

[0283] Thus, in one embodiment, the present disclosure provides a method for preparing a synergistic antiseptic composition, the method comprising: adding and mixing at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient to form a mixture to obtain a fungicidal composition.

[0284] Thus, in one embodiment, the present disclosure provides a method for controlling the growth of a fungal disease in a plant, the method comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) applying to the plant, or the locus thereof or the plant propagation material thereof, an effective amount of a synergistic fungicidal composition comprising at least one pesticidally acceptable excipient.

[0285] Although the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various modifications can be made and elements thereof substituted with equivalents without departing from the scope of the invention. In addition, many modifications can be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope of the invention. Therefore, the invention is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but it is intended to include all embodiments falling within the scope of the appended claims. Unless otherwise indicated herein or clearly contradicted by context, any combination of all possible variations of the above-described elements is included in the present invention. These and other advantages of the disclosure will become more apparent from the examples set forth herein below. These examples are provided only as illustrations of the disclosure and are not intended to be construed as limiting the disclosure. EXAMPLES

[0286] Example 1 Preparation of Ipflufenoquine 78g / 1 + Pyrimethanil 532g / 1 SC

[0287] [Table 1]

[0288] process Water, 2-bromo-2-nitro-1,3-propanediol, xanthan gum, propylene glycol, acrylic copolymer solution, sodium salt of naphthalene sulfonic acid condensate, and polyalkylene oxide block copolymer were added to a batch tank and mixed well using a mixer. Ipflufenoquine and pyrimethanil were added to the mixture and mixed until well dispersed to obtain the desired suspension concentrate.

[0289] Example 2 Preparation of Ipflufenoquine 69g / 1 + Cyprodinil 348g / 1 EW

[0290] [Table 2]

[0291] process Water, 1,2-propanediol, 2-butoxyethanol, cyclohexanone, castor oil ethoxylate, calcium linear alkylbenzene sulfonate, and tristyrylphenol ethoxylate were added to a batch tank and mixed well using a mixer. Ipflufenoquine and cyprodinil were added to the mixture and mixed until well dispersed to obtain the desired oil-in-water (EW) emulsion.

[0292] Example 3 Experiments were conducted to evaluate the biological effectiveness of the fungicidal combination of ipflufenoquine and pyrimethanil against fungal infections affecting apple crops. Table 1 gives an overview of the target crops, the combinations of active ingredients tested, and the range of application rates of the combination.

[0293] [Table 3]

[0294] Table 2 provides an overview of the treatments tested for efficacy in preventing apple scab caused by the fungus Venturia inaequalis at harvest. The combinations were applied in three separate applications: (1) Tight Cluster Pink, (2) at bloom, and (3) at first cover spray. In treatment number 2, the individual active agents were tank mixed.

[0295] [Table 4]

[0296] Table 3 shows an overview of the percentage of leaf scab severity (caused by Venturia inaequalis) observed after treatment completion. The percentage of leaf scab severity was calculated based on the total number of affected leaves.

[0297] [Table 5]

[0298] Example 4 As shown in Table 4, an experiment was conducted to evaluate the efficacy of the fungicide combination of ipflufenoquine and pyrimethanil (tank mix) against brown rot disease (Monilinia fruticola) affecting peach crop.

[0299] [Table 6]

[0300] As shown in Table 5, an experiment was conducted to evaluate the efficacy of a fungicide combination (tank mix) of ipflufenoquine and pyrimethanil against Coryneum blight (Wilsonomyces sp.) affecting peach yield.

[0301] [Table 7]

[0302] Example 5 As shown in Table 6, an experiment was conducted to evaluate the efficacy of the fungicidal combination of ipflufenoquin and pyrimethanil (both tank mix and premix) against black scab disease (Cladosporium sp.) on pecan (i.e. nuts).

[0303] [Table 8]

[0304] Example 6 An experiment was conducted to determine whether a ratio of 1:6.7 ipflufenoquine + pyrimethanil would provide a higher level of control than the ratios 1:2.5 and 1:5. The study was conducted on apple scab (Venturia inaequalis). The results are shown in Table 7. Treatment A: 0.1 ipflufenoquine:0.25 pyrimethanil μg / ml ai (ratio 1:2.5) Treatment B: 0.1 ipflufenoquine:0.5 pyrimethanil μg / ml ai (ratio 1:5) Treatment C: 0.1 ipflufenoquine:0.667 pyrimethanil μg / ml ai (ratio 1:6.7)

[0305] [Table 9]

[0306] It was observed that when the ratio of ipflufenoquine + pyrimethanil was 1:6.7, the disease growth rate was better inhibited compared to the ratios of 1:2.5 and 1:5. The lower rate of disease progression as revealed by the treatment indicates a higher level of inhibition. This was observed at the ratio of 1:6.7.

[0307] Example 7 Experiments were conducted to confirm the synergistic effect of the combination of ipflufenoquine and pyrimethanil. Significant growth inhibition was observed when the concentrations of the two fungicides were both below the minimum effective concentration (MEC). Ten of the 14 isolates tested showed evidence of synergistic effect of the combination, as shown in Table 8.

[0308] [Table 10]

Claims

1. A germicidal combination comprising: (a) at least one quinoline fungicide, and (b) at least one anilinopyrimidine fungicide; the quinoline fungicide is selected from the group consisting of ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol and salts of quinacetol, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof; A fungicidal combination, wherein the anilinopyrimidine fungicide is selected from the group consisting of pyrimethanil, cyprodinil, mepanipyrim, or combinations thereof.

2. 2. The combination of claim 1, wherein the quinoline fungicide is ipflufenoquine.

3. 2. The combination of claim 1, wherein the anilinopyrimidine fungicide is pyrimethanil.

4. 2. The combination of claim 1, wherein the anilinopyrimidine fungicide is cyprodinil.

5. 2. The combination of claim 1, wherein the combination comprises ipflufenoquine and pyrimethanil.

6. 2. The combination of claim 1, wherein the combination comprises ipflufenoquine and cyprodinil.

7. 10. The combination of claim 1, wherein the quinoline fungicide is present at a concentration ranging from about 10 to about 100 g / L.

8. 2. The combination of claim 1, wherein the anilinopyrimidine fungicide is present at a concentration ranging from about 250 to about 550 g / L.

9. 2. The combination of claim 1, wherein the weight ratio of said quinoline fungicide to said anilinopyrimidine fungicide ranges from about 50:1 to about 1:

50.

10. 2. Use of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide to inhibit the growth of fungal diseases in plants.

11. 1. A disinfectant composition comprising: (a) at least one quinoline fungicide; (b) at least one anilinopyrimidine fungicide, and (c) at least one pesticidally acceptable excipient; the quinoline fungicide is selected from the group consisting of ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol and salts of quinacetol, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof; A fungicidal composition, wherein the anilinopyrimidine fungicide is selected from the group consisting of pyrimethanil, cyprodinil, mepanipyrim, or combinations thereof.

12. 12. The composition of claim 11, wherein said quinoline fungicide is ipflufenoquine and said anilinopyrimidine fungicide is pyrimethanil.

13. 12. The composition of claim 11, wherein the pesticidally acceptable excipient is selected from one or more of a dispersant, a carrier, an emulsifier, a colorant, a thickener, a binder, an antifreeze agent, an antifoam agent, an antioxidant, a solvent, a preservative, a diluent, other adjuvant, or combinations thereof.

14. 12. The composition of claim 11, wherein the fungicidal composition comprises from about 1% w / w to about 30% w / w of a quinoline fungicide by total weight of the composition.

15. 12. The composition of claim 11, wherein the fungicidal composition comprises from about 10% w / w to about 50% w / w of an anilinopyrimidine fungicide by total weight of the composition.

16. 12. The composition of claim 11, wherein the fungicidal composition comprises from about 1% w / w to about 30% w / w of a pesticidally acceptable excipient by total weight of the composition.

17. The composition of claim 11 , wherein the composition is in the form of a liquid formulation.

18. 20. The composition of claim 17, wherein the composition is in the form of a tank mix or a premix / ready mix formulation.

19. 1. A method for controlling the growth of a fungal disease in a plant, comprising: applying to a plant, its locus, or plant propagation material an effective amount of a fungicidal combination comprising at least one quinoline fungicide and at least one anilinopyrimidine fungicide; the quinoline fungicide is selected from the group consisting of ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol and salts of quinacetol, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof; The method, wherein the anilinopyrimidine fungicide is selected from the group consisting of pyrimethanil, cyprodinil, mepanipyrim, or a combination thereof, preferably pyrimethanil or cyprodinil.

20. 1. A method for inhibiting the growth of a fungal disease in a plant, comprising: applying to a plant, its locus, or plant propagation material an effective amount of a fungicidal composition comprising at least one quinoline fungicide, at least one anilinopyrimidine fungicide, and at least one pesticidally acceptable excipient; the quinoline fungicide is selected from the group consisting of ethoxyquin, halacrinate, 8-hydroxyquinoline sulfate, ipflufenoquin, quinacetol and salts of quinacetol, such as quinacetol sulfate, quinofumelin, quinoxyfen, proquinazid, tebufloquine, or combinations thereof; The method, wherein the anilinopyrimidine fungicide is selected from the group consisting of pyrimethanil, cyprodinil, mepanipyrim, or a combination thereof, preferably pyrimethanil or cyprodinil.

21. 21. The method of claim 20, wherein the method comprises applying the fungicidal composition in the range of about 250 g a.i. / ha to about 360 g a.i. / ha.

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