CDK proteolytic factors, pharmaceutical compositions, and therapeutic applications

Abstract

Provided herein are CDK proteolysis factors, such as compounds of formula (I), and pharmaceutical compositions thereof. Also provided herein is a method of using the same for treating, preventing, or ameliorating one or more symptoms of a CDK-mediated disorder, disease, or condition. 【Chemical 1】 TIFF2025516555001241.tif23170

Claims

1. Compound of formula (I): 【Chemistry 1】 or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or its pharmaceutically acceptable salts, solvates, or hydrates; (In the formula: A is a bond, heterocyclylene, or -S(O 2 )-and; E is heteroarylene, C 6-14 It is an allerene or heterocycline; L is the linker; X is a -C(O)- or bond; R 1 is (i) hydrogen; (ii) C 1-6 alkyl, C 1-6 heteroalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-14 aryl, C 7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) -C(O)R 1a , -C(O)OR 1a , -C(O)NR 1b R 1c , -C(O)SR 1a , -C(NR 1a )NR 1b R 1c , -C(S)R 1a , -C(S)OR 1a , -C(S)NR 1b R 1c , -S(O)R 1a , -S(O) 2 R 1a , -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c wherein; R 2 , R 3 , and R 4 Each is independently (i) hydrogen, deuterium, cyano, halo, or nitro; (ii) C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, or heterocyclyl; or (iii)-C(O)R 1a , -C(O)OR 1a -C(O)NR 1b R 1c -C(O)SR 1a -C(NR 1a )NR 1b R 1c ,-C(S)R 1a , -C(S)OR 1a -C(S)NR 1b R 1c , -OR 1a ,-OC(O)R 1a -OC(O)OR 1a -OC(O)NR 1b R 1c -OC(O)SR 1a -OC(NR 1a )NR 1b R 1c ,-OC(S)R 1a , -OC(S)OR 1a -OC(S)NR 1b R 1c -OS(O)R 1a , -OS(O) 2 R 1a -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c 、 -NR 1a C(O)SR 1d 、 -NR 1a C(NR 1d )NR 1b R 1c 、 -NR 1a C(S)R 1d 、 -NR 1a C(S)OR 1d 、 -NR 1a C(S)NR 1b R 1c 、 -NR 1a S(O)R 1d 、 -NR 1a S(O) 2 R 1d 、 -NR 1a S(O)NR 1b R 1c 、 -NR 1a S(O) 2 NR 1b R 1c 、 -SR 1a 、 -S(O)R 1a 、 -S(O) 2 R 1a 、 -S(O)NR 1b R 1c 、 or -S(O) 2 NR 1b R 1c and; R E teeth, 【Chemistry 2】 and; Here: Each A E These are independently, bonded, -O-, -N(R 1b )-, -S-, C 1-6 Alkilen, C 1-6 Heteroalkylene, C 2-6 Alkenylene, C 2-6 Heteralkenylene, C 2-6 Alkinylene, C 2-6 Heteroalkylynylene, C 3-10 Cycloalkylene, C 6-14 Alliren, C 7-15 Aralkylene, heteroarylene, heterocyclylene, C 1-6 Heteroalkylene-C 6-14 Alliren, C 1-6 Heteroalkylene-heterocyclylene, or C 2-6 It is an alkynylene-heterocyclylene; Each X E Independently, C(R E1 ) or N; Y E is a bond, C 1-6 Alkylene, -O-, -S-, -S(O)-, -S(O 2 )-, or -N(R E3 )-and; Z is -CH 2 - or -C(O)-; Z 1 , Z 2 , Z 3 , and Z 4 One of them is -C= and Z 1 , Z 2 , Z 3 , and Z 4 The remaining three are, each independently, -C(R E4a )= or Z 1 is a combination; Z 2 , Z 3 , and Z 4 One of them is -C= and Z 2 , Z 3 , and Z 4 The remaining two of them are, independently, -C(R E4a ) = or -S-; Each R E1 These are, independently, hydrogen, deuterium, halo, or C 1-6 It is alkyl; Each R E2 , R E3 , and R E5 These are independently hydrogen or C 1-6 It is alkyl; Each R E4 (i) Deuterium, cyano, halo, or nitro; (ii) C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, or heterocyclyl; or (iii)-C(O)R 1a , -C(O)OR 1a -C(O)NR 1b R 1c -C(O)SR 1a -C(NR 1a )NR 1b R 1c ,-C(S)R 1a , -C(S)OR 1a -C(S)NR 1b R 1c , -OR 1a ,-OC(O)R 1a -OC(O)OR 1a -OC(O)NR 1b R 1c -OC(O)SR 1a -OC(NR 1a )NR 1b R 1c ,-OC(S)R 1a , -OC(S)OR 1a -OC(S)NR 1b R 1c -OS(O)R 1a , -OS(O) 2 R 1a -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d , -NR 1a C(NR 1d )NR 1b R 1c , -NR 1a C(S)R 1d , -NR 1a C(S)OR 1d , -NR 1a C(S)NR 1b R 1c , -NR 1a S(O)R 1d , -NR 1a S(O) 2 R 1d , -NR 1a S(O)NR 1b R 1c , -NR 1a S(O) 2 NR 1b R 1c , -SR 1a ,-S(O)R 1a , -S(O) 2 R 1a -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c and; Each R E4a Independently, hydrogen or R E4 and; Each m is independently an integer of 0, 1, or 2; and Each n is independently an integer of 0, 1, 2, or 3; and Each R 1a , R 1b , R 1c , and R 1d These are, independently, hydrogen, deuterium, and C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 It is an aralkyl, heteroaryl, or heterocyclyl; Here, each alkyl, alkylene, heteroalkyl, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, alkynylene, heteroalkylynylene, cycloalkyl, cycloalkylene, aryl, arylene, aralkyl, aralkylene, heteroaryl, heteroarylene, heterocyclyl, and heterocyclylene is optionally substituted with one or more substituents Q, where each Q is (a) deuterium, cyano, halo, imino, nitro, and oxo; (b) each of them is one or more substituents Q a C is further arbitrarily substituted. 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, and heterocyclyl; and (c)-C(O)R a , -C(O)OR a -C(O)NR b R c -C(O)SR a -C(NR a )NR b R c ,-C(S)R a , -C(S)OR a -C(S)NR b R c , -OR a ,-OC(O)R a -OC(O)OR a -OC(O)NR b R c -OC(O)SR a -OC(NR a )NR b R c ,-OC(S)R a , -OC(S)OR a -OC(S)NR b R c , -OP(O)(OR b )OR c -OS(O)R a , -OS(O) 2 R a -OS(O)NR b R c , -OS(O) 2 NR b R c , -NR b R c , -NR a C(O)R d , -NR a C(O)OR d , -NR a C(O)NR b R c , -NR a C(O)SR d , -NR a C(NR d )NR b R c , -NR a C(S)R d , -NR a C(S)OR d , -NR a C(S)NR b R c , -NR a S(O)R d , -NR a S(O) 2 R d , -NR a S(O)NR b R c , -NR a S(O) 2 NR b R c , -SR a ,-S(O)R a , -S(O) 2 R a -S(O)NR b R c , and -S(O) 2 NR b R c (Here, each R a , R b , R c , and R d (i) hydrogen or deuterium; (ii) each of them having one or more substituents Q a C is arbitrarily replaced by 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 (iii)R b and R c These, along with the N atom to which they are bonded, have one or more substituents Q a (to form a heterocycline which is optionally substituted by): independently selected from; Here, each Q a (a) Deuterium, cyano, halo, nitro, imino, and oxo; (b) C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, and heterocyclyl; and (c)-C(O)R e , -C(O)OR e -C(O)NR f R g -C(O)SR e -C(NR e )NR f R g ,-C(S)R e , -C(S)OR e -C(S)NR f R g , -OR e ,-OC(O)R e -OC(O)OR e -OC(O)NR f R g -OC(O)SR e -OC(NR e )NR f R g ,-OC(S)R e , -OC(S)OR e -OC(S)NR f R g , -OP(O)(OR f )OR g -OS(O)R e , -OS(O) 2 R e -OS(O)NR f R g , -OS(O) 2 NR f R g , -NR f R g , -NR e C(O)R h , -NR e C(O)OR f , -NR e C(O)NR f R g , -NR e C(O)SR f , -NR e C(NR h )NR f R g , -NR e C(S)R h , -NR e C(S)OR f , -NR e C(S)NR f R g , -NR e S(O)R h , -NR e S(O) 2 R h , -NR e S(O)NR f R g , -NR e S(O) 2 NR f R g , -SR e ,-S(O)R e , -S(O) 2 R e -S(O)NR f R g , and -S(O) 2 NR f R g ;(Here, each R e , R f , R g , and R h (i) hydrogen or deuterium; (ii) C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 (iii)R f and R g These atoms, together with the N atom to which they are bonded, form a heterocycline (independently selected from the following):

2. C where E is arbitrarily substituted with one or more substituents Q. 6-14 It is allirene or heteroarirene; or The compound according to claim 1, wherein E is a phenyl or monocyclic heteroarylene in which each of the one or more substituents Q is optionally substituted; or Structure of equation (II): 【Transformation 3】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof; (In the formula: Y is -C(R 5 ) = or -N =; R 5 is hydrogen or R 5a and; Each R 5a (i) deuterium, cyano, halo, or nitro; (ii) C, each optionally substituted with one or more substituents Q. 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, or heterocyclyl; or (iii)-C(O)R 1a , -C(O)OR 1a -C(O)NR 1b R 1c -C(O)SR 1a -C(NR 1a )NR 1b R 1c ,-C(S)R 1a , -C(S)OR 1a -C(S)NR 1b R 1c , -OR 1a ,-OC(O)R 1a -OC(O)OR 1a -OC(O)NR 1b R 1c -OC(O)SR 1a -OC(NR 1a )NR 1b R 1c ,-OC(S)R 1a , -OC(S)OR 1a -OC(S)NR 1b R 1c -OS(O)R 1a , -OS(O) 2 R 1a -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d , -NR 1a C(NR 1d )NR 1b R 1c , -NR 1a C(S)R 1d , -NR 1a C(S)OR 1d , -NR 1a C(S)NR 1b R 1c , -NR 1a S(O)R 1d , -NR 1a S(O) 2 R 1d , -NR 1a S(O)NR 1b R 1c , -NR 1a S(O) 2 NR 1b R 1c , -SR 1a ,-S(O)R 1a , -S(O) 2 R 1a -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c and a is an integer (0, 1, 2, or 3).

3. E is a heterocyclylene optionally substituted with one or more substituents Q; or E is a monocyclic heterocycline in which each of the one or more substituents Q is arbitrarily substituted; or E is a 6-membered heterocyclene optionally substituted with one or more substituents Q; or The compound according to claim 1, wherein E is a piperidinediyl optionally substituted with one or more substituents Q; or Structure of equation (IIIB): 【Chemistry 4】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof; (In the formula: Each R 6 (i) deuterium, cyano, halo, or nitro; (ii) C, each optionally substituted with one or more substituents Q. 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, C 6-14 Ariel, C 7-15 Aralkyl, heteroaryl, or heterocyclyl; or (iii)-C(O)R 1a , -C(O)OR 1a -C(O)NR 1b R 1c -C(O)SR 1a -C(NR 1a )NR 1b R 1c ,-C(S)R 1a , -C(S)OR 1a -C(S)NR 1b R 1c , -OR 1a ,-OC(O)R 1a -OC(O)OR 1a -OC(O)NR 1b R 1c -OC(O)SR 1a , OC(NR 1a )NR 1b R 1c ,-OC(S)R 1a , -OC(S)OR 1a -OC(S)NR 1b R 1c -OS(O)R 1a , -OS(O) 2 R 1a -OS(O)NR 1b R 1c , -OS(O) 2 NR 1b R 1c , -NR 1b R 1c , -NR 1a C(O)R 1d , -NR 1a C(O)OR 1d , -NR 1a C(O)NR 1b R 1c , -NR 1a C(O)SR 1d , -NR 1a C(NR 1d )NR 1b R 1c , -NR 1a C(S)R 1d , -NR 1a C(S)OR 1d , -NR 1a C(S)NR 1b R 1c , -NR 1a S(O)R 1d , -NR 1a S(O) 2 R 1d , -NR 1a S(O)NR 1b R 1c , -NR 1a S(O) 2 NR 1b R 1c , -SR 1a ,-S(O)R 1a , -S(O) 2 R 1a -S(O)NR 1b R 1c , or -S(O) 2 NR 1b R 1c and b is an integer (0, 1, 2, 3, or 4).

4. X is a combination; or X is -C(O)-; and / or A is a heterocyclylene bonded or optionally substituted with one or more substituents Q; or A is a monocyclic heterocycline in which A is arbitrarily substituted with one or more substituents Q; or A is a six-membered heterocyclene optionally substituted with one, two, or three substituents Q; or A is piperidine-1,4-diyl or piperazine-1,4-diyl, each optionally substituted with one, two, or three substituents Q; or A is -S(O 2 The compound according to claim 1, wherein the compound is )-.

5. Structure of equation (IIA): 【Transformation 5】 The compound according to claim 1, having, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IIB): 【Transformation 6】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IIIA): 【Transformation 7】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IIIB): 【Transformation 8】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (IIC): 【Chemistry 9】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof.

6. R E The structure of equation (EC-I): 【Chemistry 10】 The compound according to claim 1, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or R E The structure of equation (EC-Ia): 【Chemistry 11】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-Ic): 【Chemistry 12】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-Id): 【Chemistry 13】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-If): 【Chemistry 14】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-Ig): 【Chemistry 15】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-Ih): 【Chemistry 16】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant, which optionally contains R E3 is hydrogen; or R E The structure is as follows: 【Chemistry 17】 The compound having a portion thereof; or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure is as follows: [Chemistry 18] The compound having a portion thereof; or its enantiomer, mixture of enantiomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-II): 【Chemistry 19】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-II-b): 【Chemistry 20】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-II-c): 【Chemistry 21】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-II-e): 【Chemistry 22】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-II-f): 【Chemistry 23】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure is as follows: 【Chemistry 24】 The compound having a portion thereof; or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure is as follows: 【Chemistry 25】 【change】 The compound having a portion thereof; or its enantiomer, mixture of enantiomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III): 【Chemistry 26】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-c): 【Chemistry 27】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-d): 【Chemistry 28】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-e): 【Chemistry 29】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-h): 【Transformation 30】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-i): 【Chemistry 31】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure of equation (EC-III-k): 【Chemistry 32】 The compound having a portion thereof, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure is as follows: 【Transformation 33】 The compound having a portion thereof; or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or R E The structure is as follows: 【Transformation 34】 The compound having a portion thereof; or its enantiomer, mixture of enantiomers, tautomer, mixture of two or more tautomers, or isotopic variant.

7. Structure of formula (IVA): 【Chemistry 35】 The compound according to claim 2, having, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VA): 【Transformation 36】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (VIA): 【Chemistry 37】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIA): 【Transformation 38】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIIA): 【Chemistry 39】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IXA): 【Chemistry 40】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XA): 【Chemistry 41】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIA): 【Chemistry 42】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIIA): 【Chemistry 43】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIIIA): 【Chemistry 44】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIVA): 【Chemistry 45】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVA): 【Chemistry 46】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XVIA): 【Chemistry 47】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVIIA): 【Chemistry 48】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVIIIA): 【Chemistry 49】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XIXA): [Transformation 50] The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXA): 【Chemistry 51】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXIA): 【Chemistry 52】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXIIA): 【Chemistry 53】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXIIIA): 【Chemistry 54】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXVA): 【Transformation 55】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXVIA): 【Transformation 56】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXVIIA): 【Chemistry 57】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXIXA): 【Chemistry 58】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXXA): 【Chemistry 59】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXXIA): 【Transformation 60】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof.

8. Structure of equation (IVB): 【Chemistry 61】 The compound according to claim 2, having, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of the expression (VB): 【Transformation 62】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIB): 【Transformation 63】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIB): 【Chemistry 64】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIIB): 【Transformation 65】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IXB): 【Chemical Formula 66】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XB): 【Transformation 67】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIB): 【Transformation 68】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIIB): 【Transformation 69】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIIIB): 【Transformation 70】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIVB): 【Chemistry 71】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVB): 【Chemistry 72】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVIB): 【Transformation 73】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVIIB): 【Chemistry 74】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVIIIB): 【Chemistry 75】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIXB): 【Transformation 76】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXB): 【Chemical 77】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXIB): 【Transformation 78】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXIIB): 【Transformation 79】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXIIIB): 【Chemistry 80】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXVB): 【Chemistry 81】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXVIB): 【Chemistry 82】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXVIIB): 【Chemistry 83】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XXIXB): 【Chemical 84】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXXB): 【Chemical 85】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XXXIB): 【Chemical 86】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof.

9. Structure of equation (IIIC): 【Transformation 87】 The compound according to claim 3 having, or an enantiomer, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (IVC): 【Chemical 88】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (VC): 【Chemical 89】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (VIC): 【Chemistry 90】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIC): 【Chemistry 91】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (VIIIC): 【Chemistry 92】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (IXC): 【Chemistry 93】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XC): 【Chemical 94】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XIC): 【Chemical 95】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIIC): 【Chemistry 96】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XIVC): 【Chemistry 97】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of equation (XVC): 【Chem.98】 The compound having, or its enantiomer, mixture of enantiomers, diastereomer, mixture of two or more diastereomers, tautomer, mixture of two or more tautomers, or isotopic variant; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; or Structure of formula (XVIC): 【Chem.99】 The compound having, or its enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof.

10. R 1 However, C is arbitrarily substituted with one or more substituents Q. 1-6 Alkyl or C 3-10 It is cycloalkyl; or R 1 However, C is arbitrarily substituted with one or more substituents Q. 3-10 It is cycloalkyl; or R 1 However, monocyclic C is arbitrarily substituted with one or more substituents Q. 3-10 It is cycloalkyl; or R 1 However, each of these is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each optionally substituted with one, two, or three substituents Q; or R 1 However, cyclopentyl, 2-hydroxy-2-methylcyclopentyl, or 【Chemistry 100】 is; and / or R 2 However, (i) cyano or halo; (ii) C, each arbitrarily substituted with one or more substituents Q. 1-6 Alkyl, C 7-15 Aralkyl or heteroaryl; or (iii)-C(O)R 1a , -C(O)OR 1a -C(O)NR 1b R 1c , -OR 1a , or -NR 1b R 1c is; or R 2 -C(O)R 1a is; or R 2 -C(O)NR 1b R 1c is; or R 2 but is cyano, fluoro, chloro, bromo, iod, methyl, ethyl, isopropyl, hydroxymethyl, ethoxymethyl, benzyl, oxazole-5-yl, acetyl, hydroxycarbonyl, ethoxycarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, 2-ethoxy-ethoxy, or amino; or R 2 but is difluoromethyl, acetyl, or dimethylaminocarbonyl; and / or R 3 However, C is optionally substituted with hydrogen, deuterium, or one or more substituents Q. 1-6 It is alkyl; or R 3 but is hydrogen, deuterium, or methyl; or R 3 is hydrogen; or R 3 is methyl; and / or R 4 The compound according to claim 1, wherein is hydrogen.

11. Y is -C(R 5 )= and; arbitrarily R 5 However, C is optionally substituted with hydrogen, deuterium, halo, or one or more substituents Q. 1-6 It is alkyl; or R 5 but is hydrogen, fluoro, chloro, methyl, or ethyl; or R 5 is hydrogen; or Y is -N = or a is an integer of 1; or R 5a However, C is optionally substituted with deuterium, a halo, or one or more substituents Q. 1-6 It is alkyl; or R 5a but is hydrogen, fluoro, chloro, methyl, or ethyl; or a is an integer of 0. The compound according to claim 2.

12. R E1 is hydrogen; and / or R E2 is hydrogen; and / or n is an integer of 1 or 2; and / or Each R E4 However, C is independently substituted with deuterium, a halo, or one or more substituents Q. 1-6 It is alkyl; or Each R E4 However, independently, these are fluoro, chloro, methyl, isopropyl, or trifluoromethyl; or R E4 is methyl or trifluoromethyl; or n is an integer of 0; and / or R E4a but is hydrogen, deuterium, or halo; or R E4a but is hydrogen, deuterium, fluoro, or chloro; or R E4a is fluoro; and / or R E5 C is optionally substituted with hydrogen or one or more substituents Q. 1-6 It is alkyl; or R E5 is hydrogen or methyl; or R E5 is methyl; and / or A E However, (i) bond; or (ii) each of them is arbitrarily substituted with one or more substituents Q, C 2-6 Alkinylene, heterocyclylene, C 1-6 Heteroalkylene-C 6-14 Alliren, C 1-6 Alkylene-heterocyclylene, or C 2-6 It is alkynylene-heterocyclylene; or A E However, (i) bond; or (ii) each of them is optionally substituted with one or more substituents Q, heterocyclene, C 1-6 Heteroalkylene-C 6-14 Arirene, or C 1-6 It is alkylene-heterocyclylene; or A E However, (i) bond; or (ii) each of them is optionally substituted with one or more substituents Q, heterocyclene, C 1-6 Heteroalkylene-C 6-14 Arirene, or C 1-6 It is alkylene-monocyclic heterocyclylene; or A E However, (i) bond; or (ii) each of them is optionally substituted with one or more substituents Q, heterocyclene, C 1-6 Heteroalkylene-phendiyl, or C 1-6 It is alkylene-(6-membered heterocyclylene); or A E However, the bonds are piperidine-1,3-diyl, piperidine-1,4-diyl, piperadi-1,4-diyl, (phen-1,4-diyl)oxymethanediyl, (piperidine-1,4-diyl)ethingiyl, 【Chemistry 101】 is; or A E However, 【Chemical Engineering 102】 That is, The compound according to claim 1.

13. L has the following structure: 【Chemistry 103】 The compound according to claim 1, having (In the formula: Each R L Independently, each of them is arbitrarily substituted with one or more substituents Q, C 1-10 Alkilen, C 2-10 Alkenylene, C 2-10 Alkinylene, C 3-10 Cycloalkylene, C 6-14 It is an allerene, heteroarrene, or heterocycline; Each Z L These are independently, bonded, -C(O)-, -C(O)O-, and -C(O)NR 1b -, -C(O)S-, -C(NR 1a )NR 1b -, -C(S)-, -C(S)O-, -C(S)NR 1b -, -O-, -OC(O)O-, -OC(O)NR 1b -, -OC(O)S-, -OC(NR 1a )NR 1b -, -OC(S)-, -OC(S)O-, -OC(S)NR 1b -, -OS(O)-, -OS(O) 2 -, -OS(O)NR 1b -, -OS(O) 2 NR 1b -, -NR 1b -, -NR 1a C(O)NR 1b -, -NR 1a C(O)S-, -NR 1a C(NR 1d )NR 1b -, -NR 1a C(S)NR 1b -, -NR 1a S(O)NR 1b -, -NR 1a S(O) 2 NR 1b -, -S-, -S(O)-, -S(O) 2 -, -S(O)NR 1b -, or -S(O) 2 NR 1b -and; and z is an integer (1, 2, 3, 4, 5, 6, 7, 8, 9, or 10).

14. Each R L However, each of them is independently substituted with one or more substituents Q, C 1-10 Alkilen, C 2-10 Alkinylene, C 3-10 Cycloalkylene, C 6-14 It is an arirene, heteroarirene, or heterocycline; or Each R L However, independently, each of them is arbitrarily substituted with one or more substituents Q, such as methanediyl, ethane-1,2-diyl, propane-1,3-diyl, butane-1,4-diyl, pentane-1,5-diyl, hexane-1,6-diyl, heptane-1,7-diyl, octane-1,8-diyl, nonane-1,9-diyl, decane-1,10-diyl, undecane-1,11-diyl, dodecane-1,12-diyl, toridodecane-1,13-diyl, etyn-1,2-diyl, cyclobutane-1,3-diyl, cyclopentane-1,3-diyl, cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, cycloheptane-1,3-diyl, cycloheptane-1,4-diyl, bicyclo[ 2.2.2] Octane-1,4-diyl, fen-1,3-diyl, fen-1,4-diyl, pyrazole-1,3-diyl, pyrazole-1,4-diyl, imidazole-1,4-diyl, 1,2,3-triazole-1,4-diyl, pyrimidine-2,4-diyl, pyrimidine-2,5-diyl, 5,6,7,8,9,10-hexahydrocycloocta[d]-pyridazine-1,7-diyl, pyrazolidine-1,3-diyl, pyrazolidine-1,4-diyl, 1,3-dioxane-2,5-diyl, piperazine-1,4-diyl, piperidine-1,3-diyl, piperidine-1,4-diyl, or 3,9-diazaspiro[5.5]-undecane-3,9-diyl; and / or Each Z L However, independently, bonded, -C(O)-, -C(O)NR 1b -, -O-, -OC(O)NR 1b -, -NR 1b -, or -NR 1a C(O)NR 1b -is; or Each Z L are, independently, bonds, -C(O)-, -C(O)O-, -C(O)NH-, -OC(O)NH-, -O-, -NH-, -N(CH 3 )-, or -NHC(O)NH-; and / or z is an integer of 1, 2, 3, or 4; or Each R L However, each of these molecules may be independently substituted with one, two, or three substituents, each being independently fluoro or methyl: methanediyl, ethane-1,2-diyl, propane-1,3-diyl, cyclohexa-1,3-diyl, cyclohexa-1,4-diyl, phen-1,3-diyl, phen-1,4-diyl, azetidine-1,3-diyl, piperazine-1,4-diyl, piperidine-1,3-diyl The compounds are yl, piperidine-1,4-diyl, morpholine-2,4-diyl, 4,7-diazaspiro[2.5]octane-4,7-diyl, 3-azabicyclo[3.2.1]octane-3,8-diyl, 8-azabicyclo[3.2.1]-octane-3,8-diyl, 3,8-diazapicyclo[3.2.1]octane-3,8-diyl, or 2,7-diazaspiro[3.5]nonane-2,7-diyl; each Z L However, independently, associative or -O-; and z is an integer of 2, 3, 4, or 5; or Each R L However, independently, methanediyl, ethane-1,2-diyl, 1,1-difluoroethane-1,2-diyl, propane-1,3-diyl, cyclohexa-1,3-diyl, cyclohexa-1,4-diyl, phen-1,3-diyl, phen-1,4-diyl, azetidine-1,3-diyl, 3-fluoroazetidine-1,3-diyl, piperazine-1,4-diyl, 2-methylpiperazine-1,4-diyl, piperidine-1,3-diyl, piperid These are n-1,4-diyl, 4-fluoro-piperidine-1,4-diyl, morpholine-2,4-diyl, 4,7-diazaspiro[2.5]octane-4,7-diyl, 3-azabicyclo[3.2.1]-octane-3,8-diyl, 8-azabicyclo[3.2.1]octane-3,8-diyl, 3,8-diazabicyclo[3.2.1]octane-3,8-diyl, or 2,7-diazaspiro[3.5]nonane-2,7-diyl; each Z L However, independently, associative or -O-; and z is an integer of 2, 3, 4, or 5. The compound according to claim 13.

15. L, 【Chemical 104】 is; or L, 【Chemistry 105】 【change】 is; or L, 【Chemistry 106】 【change】 【change】 【change】 【change】 The compound according to claim 1.

16. Z is -CH 2 -is; and / or The compound according to claim 1, wherein m is an integer of 1.

17. 7-Cyclopentyl-2-((4-((2-(4-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A101; 7-Cyclopentyl-2-((4-((4-(4-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A102; 7-Cyclopentyl-2-((4-((6-(4-(2-(3-(2,6-dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A103; 7-Cyclopentyl-2-((4-(4-(2-(4-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A104; 7-Cyclopentyl-2-((4-(4-(4-(4-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)butyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A105; 7-Cyclopentyl-2-((4-(4-(2-(1-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperidine-4-yl)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A106; 7-Cyclopentyl-2-((4-(4-(4-(1-(2-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperidine-4-yl)butyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A107; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-dioxopiperidine-3-yl)phenoxy)acetamide)-ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A108; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-dioxopiperidine-3-yl)-4-methylphenoxy)-acetamido)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A109; 7-Cyclopentyl-2-((4-(4-(2-(2-(3-(2,6-Dioxopiperidine-3-yl)-4-(trifluoromethyl)-phenoxy)acetamido)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A110; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-dioxopiperidine-3-yl)phenoxy)acetamide)-propyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A111; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-Dioxopiperidine-3-yl)-4-methylphenoxy)-Acetamide)propyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A112; 7-Cyclopentyl-2-((4-(4-(3-(2-(3-(2,6-Dioxopiperidine-3-yl)-4-(trifluoromethyl)-phenoxy)acetamido)propyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A113; 7-Cyclopentyl-2-((4-((2-(4-(2-(4-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A114; 7-Cyclopentyl-2-((4-((4-(4-(2-(4-(2,6-Dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A115; 7-Cyclopentyl-2-((4-((6-(4-(2-(4-(2,6-dioxopiperidine-3-yl)phenoxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A116; 7-Cyclopentyl-2-((4-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A117; 7-Cyclopentyl-2-((4-(4-(4-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A118; 7-Cyclopentyl-2-((4-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A119; 7-Cyclopentyl-2-((4-(4-(3-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)-phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A120; 7-Cyclopentyl-2-((4-(4-(2-(3-(2,6-dioxopiperidine-3-yl)phenoxy)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A121; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A122; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A123; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A124; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A125; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A126; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A127; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A128; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A129; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-Ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A130; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-Ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A131; 7-Cyclopentyl-2-((4-((4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)methyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A132; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A133; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A134; 7-Cyclopentyl-2-((4-(2-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)piperazine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A135; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A136; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A137; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A138; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-4-yl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A139; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-4-yl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A140; 7-Cyclopentyl-2-((4-(4-((1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A141; 7-Cyclopentyl-2-((4-(4-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A142; 7-Cyclopentyl-2-((4-(4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A143; 7-Cyclopentyl-2-((4-(4-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A144; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A145; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A146; 7-Cyclopentyl-2-((5-(4-(3-(4-(3-(2,6-Dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A147; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A148; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-Dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A149; 7-Cyclopentyl-2-((5-(4-(4-(4-(3-(2,6-Dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A150; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-Dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-benzyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A151; 7-Cyclopentyl-2-((5-(4-(4-((4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-methyl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A152; 7-Cyclopentyl-2-((5-(4-(4-(4-(3-(2,6-Dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-benzyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A153; 7-Cyclopentyl-2-((5-(4-((4-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-methyl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A154; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)cyclohexyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A155; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A156; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidine-3-yl)phenoxy)ethyl)-piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A157; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A158; 7-Cyclopentyl-2-((5-(4-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A159; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidine-3-yl)phenoxy)ethyl)-piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A160; 7-Cyclopentyl-2-((5-(4-(3-(4-(4-(2,6-Dioxopiperidine-3-yl)phenyl)piperazine-1-yl)propyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A161; 7-Cyclopentyl-2-((5-(4-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A162; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)methyl)piperidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A163; 7-Cyclopentyl-2-((5-(4-(1-(((2S)-4-(4-(2,6-dioxopiperidine-3-yl)phenyl)morpholine-2-yl)methyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A164; 7-Cyclopentyl-2-((5-(4-(1-(((2R)-4-(4-(2,6-dioxopiperidine-3-yl)phenyl)morpholine-2-yl)methyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A165; 7-Cyclopentyl-2-((5-(4-(3-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)-cyclohexyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A166; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)-methyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A167; 7-Cyclopentyl-2-((5-(4-(((2S)-4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)morpholine-2-yl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A168; 7-Cyclopentyl-2-((5-(4-(((2R)-4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)morpholine-2-yl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A169; 7-Cyclopentyl-2-((5-(4-((4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-cyclohexyl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A170; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)cyclohexyl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A171; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)ethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A172; 7-Cyclopentyl-2-((5-(4-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)ethyl)cyclohexyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A173; 7-Cyclopentyl-2-((5-(4-(1-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)ethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A174; 7-Cyclopentyl-2-((5-(4-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A175; 7-Cyclopentyl-2-((5-(4-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A176; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A177; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A178; 7-Cyclopentyl-2-((5-(4-(1-(3-(4-(2,6-dioxopiperidine-3-yl)phenoxy)propyl)-piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A179; 7-Cyclopentyl-2-((5-(4-(3-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-propyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A180; 7-Cyclopentyl-2-((5-(4-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-4-yl)cyclohexyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A181; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A182; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A183; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A184; 7-Cyclopentyl-2-((5-((4-(4-(4-(2,6-Dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-Piperidine-1-yl)Methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A185; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)oxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A186; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)methoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A187; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A188; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A189; 7-Cyclopentyl-2-((5-(2-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A190; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A191; 7-Cyclopentyl-2-((5-(2-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A192; 7-Cyclopentyl-2-((5-(2-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A193; 7-Cyclopentyl-2-((5-(4-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A194; 7-Cyclopentyl-2-((5-(4-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A195; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A196; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-cyclohexyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A197; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-cyclohexyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A198; 7-Cyclopentyl-2-((5-(4-(1-(3-(3-(2,6-Dioxopiperidine-3-yl)phenoxy)propyl)-Piperidine-4-yl)Piperazine-1-yl)Pyridine-2-yl)amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]Pyrimidine-6-Carboxamide A199; 7-Cyclopentyl-2-((5-((4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A200; 7-Cyclopentyl-2-((5-(2-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A201; 7-Cyclopentyl-2-((5-(3-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)propyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A202; 7-Cyclopentyl-2-((5-(3-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)propyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A203; 7-Cyclopentyl-2-((5-(3-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)propyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A204; 7-Cyclopentyl-2-((5-(3-(1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)propyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A205; 7-Cyclopentyl-2-((5-(2-(4-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A206; 7-Cyclopentyl-2-((5-((2S)-2-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)methyl)morpholino)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A207; 7-Cyclopentyl-2-((5-((2R)-2-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)methyl)morpholino)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A208; 7-Cyclopentyl-2-((5-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)-piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A209; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-3-yl)oxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A210; 7-Cyclopentyl-2-((5-((3-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A211; 7-Cyclopentyl-2-((5-((1'-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[3,4'-bipiperidine]-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A212; 7-Cyclopentyl-2-((5-(2-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A213; 7-Cyclopentyl-2-((5-(4-((4-(4-(4-(2,6-Dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-piperidine-1-yl)methyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A214; 7-Cyclopentyl-2-((5-(4-(4-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-benzyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A215; 7-Cyclopentyl-2-((5-(4-((4-((4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-methyl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A216; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A217; 7-Cyclopentyl-2-((5-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A218; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-methyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A219; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-methyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A220; 7-Cyclopentyl-2-((5-(4-((1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A221; 7-Cyclopentyl-2-((5-(1-((1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-methyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A222; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-methyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A223; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-methyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A224; 7-Cyclopentyl-2-((5-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-1'-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A225; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A226; 7-Cyclopentyl-2-((5-(1-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A227; 7-Cyclopentyl-2-((5-(1-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A228; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A229; 7-Cyclopentyl-2-((5-(4-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A230; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A231; 7-Cyclopentyl-2-((5-(4-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A232; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A233; 7-Cyclopentyl-2-((5-(1-(2-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A234; 7-Cyclopentyl-2-((5-(1-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A235; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-1'-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A236; 7-Cyclopentyl-2-((5-(1'-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-[4,4'-bipiperidine]-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A237; 7-Cyclopentyl-2-((5-(1'-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-[1,4'-bipiperidine]-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A238; 7-Cyclopentyl-2-((5-(2-(4-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A239; 7-Cyclopentyl-2-((5-(2-(1'-(3-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A240; 7-Cyclopentyl-2-((5-(2-(1'-(3-(2,6-dioxopiperidine-3-yl)phenyl)-[4,4'-bipiperidine]-1-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A241; 7-Cyclopentyl-2-((5-(2-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-1'-yl)ethyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A242; 7-Cyclopentyl-2-((5-(2-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A243; 7-Cyclopentyl-2-((5-(2-(4-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A244; 7-Cyclopentyl-N,N-dimethyl-2-((5-(4-(1-(4-(3-methyl-2,6-dioxopiperidine-3-yl)-phenethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A245; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-ethyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A246; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A247; 7-Cyclopentyl-2-((5-(4-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-ethyl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A248; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-propoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A249; 7-Cyclopentyl-2-((5-(3-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-propoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A250; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A251; 7-Cyclopentyl-2-((5-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A252; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-4-fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A253; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A254; 7-Cyclopentyl-2-((5-(4-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)-piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A255; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)-methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A256; 7-Cyclopentyl-2-((5-(4-((1-(3-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)-methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A257; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A258; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A259; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidine-3-yl)phenyl)-2,2-difluoroethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A260; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidine-3-yl)phenyl)-2,2-difluoro-ethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A261; 7-Cyclopentyl-2-((5-(4-(1-(2-(4-(2,6-dioxopiperidine-3-yl)phenyl)-2,2-difluoroethyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A262; 7-Cyclopentyl-2-((5-(4-(1-(2-(3-(2,6-dioxopiperidine-3-yl)phenyl)-2,2-difluoroethyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A263; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A264; 7-Cyclopentyl-2-((5-(4-(1-(3-(2,6-dioxopiperidine-3-yl)benzyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A265; 7-Cyclopentyl-2-((5-(4-(3-(2,6-dioxopiperidine-3-yl)phenethyl)-4-fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A266; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)-4-fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A267; 7-Cyclopentyl-2-((5-(4-(3-(2,6-Dioxopiperidine-3-yl)benzyl)-4-Fluoro-[1,4'-Bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide A268; 7-Cyclopentyl-2-((5-(4-(3-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-3-fluoroazetidine-1-yl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A269; 7-Cyclopentyl-2-((5-(4-(3-(3-(2,6-dioxopiperidine-3-yl)phenethyl)-3-fluoroazetidine-1-yl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A270; 7-Cyclopentyl-2-((5-(3-(1-(2-(4-(2,6-dioxopiperidine-3-yl)phenyl)-2,2-difluoro--ethyl)piperidine-4-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A271; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A272; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidine-3-yl)phenethyl)piperazine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A273; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A274; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-Dioxopiperidine-3-yl)benzyl)piperazine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A275; 7-Cyclopentyl-2-((5-(4-(3-(4-(2,6-Dioxopiperidine-3-yl)benzyl)-3-Fluoroazetidine-1-yl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A276; 7-Cyclopentyl-2-((5-(4-(3-(3-(2,6-Dioxopiperidine-3-yl)benzyl)-3-Fluoroazetidine-1-yl)piperidine-1-yl)pyridine-2-yl)amino)-N,N-Dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A277; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A278; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenethyl)-4-fluoropiperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A279; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidine-3-yl)phenethyl)piperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A280; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidine-3-yl)phenethyl)-4-fluoropiperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A281; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-Dioxopiperidine-3-yl)benzyl)-4-Fluoropiperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A282; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)-4-fluoropiperidine-1-yl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A283; 7-Cyclopentyl-2-((5-(4-((3-(4-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-1-yl)-methyl)-4-fluoropiperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A284; 7-Cyclopentyl-2-((5-(4-((3-(3-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-1-yl)-methyl)-4-fluoropiperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A285; 7-Cyclopentyl-2-((5-(1-((1-(3-(2,6-Dioxopiperidine-3-yl)phenyl)-4-Fluoropiperidine-4-yl)methyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A286; 7-Cyclopentyl-2-((5-(1-((1-(4-(2,6-dioxopiperidine-3-yl)phenyl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A287; 7-Cyclopentyl-2-((5-(4-((4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-methyl)-4-fluoropiperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A288; 7-Cyclopentyl-2-((5-(4-((4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-methyl)-4-fluoropiperidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A289; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorophenyl)-piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A290; 7-Cyclopentyl-2-((5-(4-(2-(1-(4-(2,6-dioxopiperidine-3-yl)-2-fluorophenyl)-piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A291; 2-((5-(4-(2-(1-(3-chloro-4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)ethyl)-piperazine-1-yl)pyridine-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A292; 2-((5-(4-(2-(1-(2-chloro-4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-4-yl)ethyl)-piperazine-1-yl)pyridine-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A293; 7-Cyclopentyl-2-((5-(3-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A294; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,6-dioxopiperidine-3-yl)phenyl)azetidine-3-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A295; 7-Cyclopentyl-2-((5-(3-(4-(3-(2,6-dioxopiperidine-3-yl)phenyl)piperazine-1-yl)-azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A296; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidine-3-yl)-5-fluorophenyl)-piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A297; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,6-dioxopiperidine-3-yl)-4-fluorophenyl)-piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A298; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorophenethyl)-4-fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A299; 7-Cyclopentyl-2-((5-((1'-(3-(2,6-dioxopiperidine-3-yl)phenyl)-[1,4'-bipiperidine]-4-yl)methoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A300; 7-Cyclopentyl-2-((5-(3-(2-(4-(4-(2,6-dioxopiperidine-3-yl)phenyl)piperidine-1-yl)-1,1-difluoroethyl)azetidine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A351; 7-Cyclopentyl-2-((5-(4-(2-(1-(5-(2,6-dioxopiperidine-3-yl)-2-fluorophenyl)-piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A352; 7-Cyclopentyl-2-((5-(4-(4-(2,6-dioxopiperidine-3-yl)-2-fluorophenethyl)-4-fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A353; 7-Cyclopentyl-2-((4-((2-(4-(2-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-phenoxy)acetyl)piperazine-1(2H)-ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A401; 7-Cyclopentyl-2-((4-((4-(4-(2-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenoxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A402; 7-Cyclopentyl-2-((4-((6-(4-(2-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-phenoxy)acetyl)piperazine-1(2H)-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A403; 7-Cyclopentyl-2-((4-((2-(4-(2-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-phenoxy)acetyl)piperazine-1(2H)-ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A404; 7-Cyclopentyl-2-((4-((4-(4-(2-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-phenoxy)acetyl)piperazine-1(2H)-butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A405; 7-Cyclopentyl-2-((4-((6-(4-(2-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-phenoxy)acetyl)piperazine-1(2H)-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A406; 7-Cyclopentyl-2-((4-(4-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A407; 7-Cyclopentyl-2-((5-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A408; 7-Cyclopentyl-2-((4-(4-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A409; 7-Cyclopentyl-2-((4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenethyl)-piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A410; 7-Cyclopentyl-2-((5-(4-(2-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenoxy)-ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A411; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A412; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A413; 7-Cyclopentyl-2-((5-((4-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A414; 7-Cyclopentyl-2-((5-(2-(4-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)ethoxy)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A415; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A416; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A417; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperazine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A418; 7-Cyclopentyl-2-((5-((4-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)methyl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A419; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperidine-4-yl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A420; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperidine-4-yl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A421; 7-Cyclopentyl-2-((4-(2-(4-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperazine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A422; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperazine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A423; 7-Cyclopentyl-2-((4-(2-(4-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperazine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A424; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)piperidine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A425; 7-Cyclopentyl-2-((4-(2-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)piperidine-1-yl)ethyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A426; 7-Cyclopentyl-2-((4-(2-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperazine-1-yl)piperidine-1-yl)ethoxy)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A427; 7-Cyclopentyl-2-((4-(4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenethyl)-piperidine-4-yl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A428; 7-Cyclopentyl-2-((4-(4-(1-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenethyl)-Piperidin-4-yl)Piperazine-1-yl)Phenyl)amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide A429; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A430; 7-Cyclopentyl-2-((4-(4-((1-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperidine-4-yl)methyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A431; 7-Cyclopentyl-2-((4-(4-((1-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperidine-4-yl)methyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A432; 7-Cyclopentyl-2-((4-(4-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperidine-1-yl)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A433; 7-Cyclopentyl-2-((4-(4-(2-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperidine-1-yl)ethyl)piperazine-1-yl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A434; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenethyl)-Piperidin-4-yl)Piperazine-1-yl)Pyridine-2-yl)amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide A435; 2-((5-(4-(2-(1-(3-chloro-4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A436; 7-Cyclopentyl-2-((5-(4-((1-(4-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperidine-4-yl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A437; 2-((5-(4-((1-(3-chloro-4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)piperidine-4-yl)methyl)piperazine-1-yl)pyridine-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A438; 7-Cyclopentyl-2-((5-(4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A439; 2-((5-(4-(1-(2-(3-chloro-4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)phenyl)-2,2-difluoroethyl)piperidine-4-yl)piperazine-1-yl)pyridine-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A440; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,6-Dioxopiperidine-3-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A501; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,6-Dioxopiperidine-3-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A502; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,6-dioxopiperidine-3-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A503; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,6-Dioxopiperidine-3-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamide A504; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,6-Dioxopiperidine-3-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A505; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,6-dioxopiperidine-3-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A506; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A551; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A552; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-7-yl)oxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A553; 7-Cyclopentyl-2-((4-((2-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)ethyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A554; 7-Cyclopentyl-2-((4-((4-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)butyl)carbamoyl)phenyl)amino)N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A555; 7-Cyclopentyl-2-((4-((6-(4-(2-((3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-6-yl)oxy)acetyl)piperazine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A556; 7-Cyclopentyl-2-((5-(4-(2-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-6-yl)ethyl)-4-Fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A557; 7-Cyclopentyl-2-((5-(4-(2-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-7-yl)ethyl)-4-Fluoro-[1,4'-bipiperidine]-1'-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A558; 7-Cyclopentyl-2-((5-(4-(2-(1-(3-(2,4-Dioxotetrahydropyrimidine-1(2H)-yl)-1-methyl-1H-indazole-6-yl)piperidine-4-yl)ethyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A559; 7-Cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidine-3-yl)-1,3-dioxoisoindorin-4-yl)-amino)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A601; 7-Cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidine-3-yl)-1,3-dioxoisoindorin-4-yl)-amino)hexyl)(methyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A602; 7-Cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidine-3-yl)-1,3-dioxoisoindorin-4-yl)-glycyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A603; 7-Cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidine-3-yl)-1-oxoisoindorin-4-yl)-glycyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A611; 7-Cyclopentyl-2-((4-((2-(4-(2,6-Dioxopiperidine-3-yl)-6-Fluoro-1-Oxoisoindorin-4-yl)Piperidin-1-yl)Ethyl)Carbamoyl)Phenyl)Amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]Pyrimidine-6-Carboxamide A612; 7-Cyclopentyl-2-((4-((4-(4-(2-(2,6-Dioxopiperidine-3-yl)-6-Fluoro-1-oxoisoindorin-4-yl)piperidine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A613; 7-Cyclopentyl-2-((4-((6-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxoisoindorin-4-yl)piperidine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A614; 7-Cyclopentyl-2-((5-(4-(2-(4-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxo-isoindoline-4-yl)piperidine-1-yl)acetyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A615; 7-Cyclopentyl-2-((5-(4-(3-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxo-isoindoline-4-yl)piperidine-1-yl)propanoyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A616; 7-Cyclopentyl-2-((5-(4-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxoisoindorin-4-yl)piperidine-1-yl)butanoyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A617; 7-Cyclopentyl-2-((4-((2-(4-(2-(2,6-Dioxopiperidine-3-yl)-6-Fluoro-1-Oxoisoindorin-5-yl)Piperidin-1-yl)Ethyl)Carbamoyl)Phenyl)Amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]Pyrimidine-6-Carboxamide A618; 7-Cyclopentyl-2-((4-((4-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxoisoindorin-5-yl)piperidine-1-yl)butyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A619; 7-Cyclopentyl-2-((4-((6-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxoisoindorin-5-yl)piperidine-1-yl)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A620; 7-Cyclopentyl-2-((5-(4-(2-(4-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxo-isoindoline-5-yl)piperidine-1-yl)acetyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A621; 7-Cyclopentyl-2-((5-(4-(3-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxo-isoindoline-5-yl)piperidine-1-yl)propanoyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A622; 7-Cyclopentyl-2-((5-(4-(4-(4-(2-(2,6-dioxopiperidine-3-yl)-6-fluoro-1-oxo-isoindorin-5-yl)piperidine-1-yl)butanoyl)piperazine-1-yl)pyridine-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A623; 7-Cyclopentyl-2-((4-((4-((5-(2,6-dioxopiperidine-3-yl)-4-oxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl)methoxy)benzyl)carbamoyl)phenyl)amino)N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide A651; 7-Cyclopentyl-2-((4-((2-((4-((5-(2,6-Dioxopiperidine-3-yl)-4-Oxo-5,6-Dihydro-4H-Thieno[3,4-c]Pyrrole-1-yl)Methoxy)benzyl)amino)ethyl)carbamoyl)phenyl)amino)N,N-Dimethyl-7H-Pyrrolo[2,3-d]Pyrimidine-6-Carboxamide A652; 7-Cyclopentyl-2-((4-((4-((4-((5-(2,6-Dioxopiperidine-3-yl)-4-Oxo-5,6-Dihydro-4H-Thieno[3,4-c]Pyrrole-1-yl)Methoxy)benzyl)amino)butyl)carbamoyl)phenyl)amino)-N,N-Dimethyl-7H-Pyrrolo[2,3-d]Pyrimidine-6-Carboxamide A653; 7-Cyclopentyl-2-((4-((4-((5-(2,6-Dioxopiperidine-3-yl)-4-Oxo-5,6-Dihydro-4H-Thieno[3,4-c]Pyrrole-1-yl)Methoxy)benzyl)Carbamoyl)Phenyl)amino)-N,N-Dimethyl-7H-Pyrrolo-[2,3-d]Pyrimidine-6-Carboxamide A654; 3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-2-oxoethoxy)phenyl)piperidine-2,6-dione B101; 3-(3-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-3-oxopropoxy)phenyl)piperidine-2,6-dione B102; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-2-(3-(2,6-dioxopiperidine-3-yl)-2-methylphenoxy)acetamide B103; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-2-(3-(2,6-dioxopiperidine-3-yl)-2-(trifluoromethyl)phenoxy)acetamide B104; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-2-(3-(2,6-dioxopiperidine-3-yl)-4-methylphenoxy)acetamide B105; N-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-2-(3-(2,6-dioxopiperidine-3-yl)-4-(trifluoromethyl)phenoxy)acetamide B106; N-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)-2-(3-(2,6-dioxopiperidine-3-yl)-2-methylphenoxy)acetamide B107; N-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)-2-(3-(2,6-dioxopiperidine-3-yl)-2-(trifluoromethyl)phenoxy)acetamide B108; N-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)-2-(3-(2,6-dioxopiperidine-3-yl)-4-methylphenoxy)acetamide B109; N-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)-2-(3-(2,6-dioxopiperidine-3-yl)-4-(trifluoromethyl)phenoxy)acetamide B110; 3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B111; 3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B112; 3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethoxy)phenyl)piperidine-2,6-dione B113; 3-(3-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B114; 3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B115; 3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethoxy)phenyl)piperidine-2,6-dione B116; 3-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propoxy)phenyl)piperidine-2,6-dione B117; 3-(3-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propoxy)phenyl)piperidine-2,6-dione B118; 3-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B119; 3-(4-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B120; 3-(4-((4-(4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione B121; 3-(3-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B122; 3-(3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B123; 3-(3-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione B124; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B125; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B126; 3-(4-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)ethyl)phenyl)piperidine-2,6-dione B127; 3-(3-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)ethyl)phenyl)piperidine-2,6-dione B128; 3-(4-((1-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B129; 3-(3-((1-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B130; 3-(4-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B131; 3-(4-(4-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B132; 3-(4-(4-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B133; 3-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B134; 3-(3-(4-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B135; 3-(3-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B136; 3-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propoxy)phenyl)piperidine-2,6-dione B137; 3-(3-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propoxy)phenyl)piperidine-2,6-dione B138; 3-(4-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)benzyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B139; 3-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)benzyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B140; 3-(3-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)benzyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B141; 3-(3-(4-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)benzyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B142; 3-(4-((4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B143; 3-(4-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B144; 3-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B145; 3-(3-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B146; 3-(4-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B147; 3-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B148; 3-(3-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B149; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B150; 3-(4-(2-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B151; 3-(4-(2-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)ethoxy)phenyl)piperidine-2,6-dione B152; 3-(4-(2-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B153; 3-(3-(2-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)-ethoxy)phenyl)piperidine-2,6-dione B154; 3-(4-(3-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)propoxy)phenyl)piperidine-2,6-dione B155; 3-(3-(3-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)propoxy)phenyl)piperidine-2,6-dione B156; 3-(4-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenethyl)-piperazine-1-yl)phenyl)piperidine-2,6-dione B157; 3-(4-(4-(2-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenoxy)-ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B158; 3-(4-(4-(2-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenoxy)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B159; 3-(3-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B160; 3-(4-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B161; 3-(4-((1-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperidine-4-yl)oxy)phenyl)piperidine-2,6-dione B162; 3-(4-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B163; 3-(4-(4-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B164; 3-(4-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)-[1,4'-bipiperidine]-1'-yl)phenyl)-piperidine-2,6-dione B165; 3-(4-(4-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B166; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-[1,4'-bipiperidine]-1'-yl)phenyl)-piperidine-2,6-dione B167; 3-(4-(4-(3-((4-((8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)-amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B168; 3-(4-(4-(3-((4-((8-cyclopentyl-6-(difluoromethyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B169; 3-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B170; 3-(4-(4-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B171; 3-(4-((S)-2-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)-morpholino)phenyl)piperidine-2,6-dione B172; 3-(4-((R)-2-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)-morpholino)phenyl)piperidine-2,6-dione B173; 3-(4-((4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione B174; 3-(4-(2-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)piperidine-1-yl)ethyl)-phenyl)piperidine-2,6-dione B175; 3-(4-(3-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)methyl)azetidine-1-yl)phenyl)piperidine-2,6-dione B176; 3-(4-(4-(((S)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)piperidine-1-yl)phenyl)piperidine-2,6-dione B177; 3-(4-(4-(((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)piperidine-1-yl)phenyl)piperidine-2,6-dione B178; 3-(4-(4-((4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)cyclohexyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B179; 3-(4-(4-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B180; 3-(4-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)ethyl)phenyl)piperidine-2,6-dione B181; 3-(4-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B182; 3-(4-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)propyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B183; 3-(4-(3-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)propoxy)phenyl)piperidine-2,6-dione B184; 3-(4-(1'-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-[4,4'-bipiperidine]-1-yl)phenyl)-piperidine-2,6-dione B185; 3-(4-(4-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B186; 3-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2yl)amino)pyridine-3-yl)piperazine-1-yl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B187; 3-(4-(4-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B188; 3-(4-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B189; 3-(4-(4-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)cyclohexyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B190; 3-(3-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)ethoxy)phenyl)piperidine-2,6-dione B191; 3-(3-(3-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)propoxy)phenyl)piperidine-2,6-dione B192; 3-(4-(4-(1-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B193; 3-(4-(4-(4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B194; 3-(4-(1'-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)methyl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B195; 3-(4-(4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)methyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B196; 3-(4-(4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B197; 3-(4-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B198; 3-(4-(4-(((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)methyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B199; 3-(4-(4-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B200; 3-(4-(4-(1-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B201; 3-(4-(1'-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B202; 3-(4-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B203; 3-(4-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B204; 3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B205; 3-(4-(1'-(3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)propyl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B206; 3-(4-(4-(1-(3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)propyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B207; 3-(4-(4-(4-(3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)propyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B208; 3-(4-(4-(3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)propyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B209; 3-(3-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B210; 3-(4-(4-((((S)-4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)morpholine-2-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B211; 3-(4-(4-((((R)-4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)morpholine-2-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B212; 3-(3-(4-((((S)-4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)morpholine-2-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B213; 3-(4-(2-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B214; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-4-yl)ethyl)phenyl)piperidine-2,6-dione B215; 3-(4-((S)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)phenyl)piperidine-2,6-dione B216; 3-(4-((R)-2-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)phenyl)piperidine-2,6-dione B217; 3-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B218; 3-(4-(4-(1-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperidine-3-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B219; 3-(3-(4-(1-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)methyl)piperidine-3-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B220; 3-(4-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperidine-3-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B221; 3-(3-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperidine-3-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B222; 3-(3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperidine-4-yl)piperazine-1-yl)-phenyl)piperidine-2,6-dione B223; 3-(4-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B224; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B225; 3-(4-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B226; 3-(4-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B227; 3-(4-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)azetidine-1-yl)phenyl)piperidine-2,6-dione B228; 3-(4-(2-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)-2,7-diazaspiro[3.5]nonane-7-yl)phenyl)piperidine-2,6-dione B229; 3-(4-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B230; 3-(4-(1-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B231; 3-(3-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B232; 3-(3-(1-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B233; 3-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)propoxy)phenyl)piperidine-2,6-dione B234; 3-(4-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B235; 3-(3-(4-(3-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)propyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B236; 3-(4-(3-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)propoxy)phenyl)piperidine-2,6-dione B237; 3-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B238; 3-(4-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B239; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B240; 3-(4-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-4-yl)phenyl)piperidine-2,6-dione B241; 3-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B242; 3-(3-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B243; 3-(3-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B244; 3-(3-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-4-yl)phenyl)piperidine-2,6-dione B245; 3-(4-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B246; 3-(4-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B247; 3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B248; 3-(3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B249; 3-(3-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B250; 3-(3-(4-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B251; 3-(4-(1'-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)methyl)-[1,4'-bipiperidine]-4-yl)phenyl)piperidine-2,6-dione B252; 3-(4-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B253; 3-(4-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B254; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B255; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B256; 3-(3-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B257; 3-(3-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B258; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B259; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B260; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B261; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[4,4'-bipiperidine]-1-yl)ethyl)phenyl)piperidine-2,6-dione B262; 3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-1'-yl)ethyl)phenyl)piperidine-2,6-dione B263; 3-(3-(4-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B264; 3-(3-(4-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B265; 3-(3-(4-(((6-(((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)methyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B266; 3-(3-(1'-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)-[4,4'-bipiperidine]-1-yl)phenyl)piperidine-2,6-dione B267; 3-(3-(4-(1-(2-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B268; 3-(3-(4-(1-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B269; 3-(3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B270; 3-(4-(1'-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)-[1,4'-bipiperidine]-4-yl)phenyl)piperidine-2,6-dione B271; 3-(4-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B272; (S)-3-(4-(4-((((S)-4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)morpholin-2-yl)methyl)piperazine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B273; 3-(4-(1-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B274; 3-(4-((1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-[1,4'-bipiperidine]-4-yl)methyl)phenyl)piperidine-2,6-dione B275; 3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperazine-1-yl)phenyl)piperidine-2,6-dione B276; 3-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B277; 3-(4-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)ethyl)phenyl)piperidine-2,6-dione B278; 3-(3-(3-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)azetidine-1-yl)phenyl)piperidine-2,6-dione B279; 3-(4-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)-1,1-difluoroethyl)phenyl)-piperidine-2,6-dione B280; 3-(3-(2-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)-1,1-difluoroethyl)phenyl)-piperidine-2,6-dione B281; 3-(4-(2-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)-1,1-difluoroethyl)phenyl)-piperidine-2,6-dione B282; 3-(3-(2-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)-1,1-difluoroethyl)phenyl)-piperidine-2,6-dione B283; 3-(4-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)methyl)phenyl)piperidine-2,6-dione B284; 3-(3-((3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)methyl)phenyl)piperidine-2,6-dione B285; 3-(3-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)ethyl)phenyl)piperidine-2,6-dione B286; 3-(4-((1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)methyl)phenyl)piperidine-2,6-dione B287; 3-(3-((1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)methyl)phenyl)piperidine-2,6-dione B288; 3-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)phenyl)piperidine-2,6-dione B289; 3-(3-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)phenyl)piperidine-2,6-dione B290; 3-(4-((1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)methyl)phenyl)piperidine-2,6-dione B291; 3-(3-((1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)methyl)phenyl)piperidine-2,6-dione B292; 3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoropiperidine-4-yl)methyl)azetidine-3-yl)phenyl)piperidine-2,6-dione B293; 3-(3-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoropiperidine-4-yl)methyl)azetidine-3-yl)phenyl)piperidine-2,6-dione B294; 3-(4-(2-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B295; 3-(3-(2-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B296; 3-(4-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B297; 3-(3-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B298; 3-(3-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperidine-4-yl)ethyl)phenyl)piperidine-2,6-dione B299; 3-(3-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)4-fluoropiperidine-4-yl)ethyl)phenyl)piperidine-2,6-dione B300; 3-(3-(8-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)-3-azabicyclo[3.2.1]octan-3-yl)-phenyl)piperidine-2,6-dione B301; 3-(3-(3-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)-8-azabicyclo[3.2.1]octan-8-yl)-phenyl)piperidine-2,6-dione B302; 3-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)piperidine-1-yl)-phenyl)piperidine-2,6-dione B303; 3-(3-(4-((8-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B304; 3-(3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-piperidine-2,6-dione B305; 3-(4-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-piperidine-2,6-dione B306; (S)-3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B307; (R)-3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)-3-methyl-piperidine-2,6-dione B308; (S)-3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B309; (R)-3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B310; 3-(4-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B311; 3-(3-(1-((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoropiperidine-4-yl)methyl)piperidine-4-yl)phenyl)piperidine-2,6-dione B312; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-fluorophenyl)piperidine-2,6-dione B313; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-3-fluorophenyl)piperidine-2,6-dione B314; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-chlorophenyl)piperidine-2,6-dione B315; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-3-chlorophenyl)piperidine-2,6-dione B316; 3-(4-(3-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)azetidine-1-yl)phenyl)piperidine-2,6-dione B317; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-5-fluorophenyl)-piperidine-2,6-dione B318; 3-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B319; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-3-fluorophenyl)-piperidine-2,6-dione B320; 3-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B321; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-fluorophenyl)-piperidine-2,6-dione B322; 3-(3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-piperidine-2,6-dione B323; 3-(4-(4-(4-(2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)oxy)ethyl)piperazine-1-yl)piperidine-1-yl)phenyl)piperidine-2,6-dione B324; 3-(4-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethoxy)phenyl)-piperidine-2,6-dione B351; 3-(4-(4-(((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B352; 3-(3-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)ethoxy)phenyl)-piperidine-2,6-dione B353; 3-(4-(4-(((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)methyl)-[1,4'-bipiperidine]-1'-yl)phenyl)piperidine-2,6-dione B354; 3-(4-(4-(1-(2-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)-ethyl)piperidine-4-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B355; 3-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione B356; 3-(4-(4-((4-((3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)-phenyl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B357; 4-(3-(4-((4-((4-((6-((difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)-phenyl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)piperidine-2,6-dione B358; 3-(4-(2-(4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)ethyl)phenyl)piperidine-2,6-dione B359; 3-(4-(4-((4-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)piperazine-1-yl)-piperidine-1-yl)phenyl)piperidine-2,6-dione B360; 3-(3-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperidine-4-yl)oxy)phenyl)-3-methylpiperidine-2,6-dione B361; 3-(4-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperidine-4-yl)oxy)phenyl)-3-methylpiperidine-2,6-dione B362; 3-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-piperidine-2,6-dione B363; 3-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)azetidine-3-yl)piperazine-1-yl)phenyl)piperidine-2,6-dione B364; 3-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-4-fluorophenyl)-piperidine-2,6-dione B365; 3-(3-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B366; (S)-3-(3-(4-((4-((6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B367; (S)-3-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)phenyl)-3-methylpiperidine-2,6-dione B368; (R)-3-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)phenyl)-3-methylpiperidine-2,6-dione B369; 3-(4-(7-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-4,7-diazaspiro[2.5]octan-4-yl)phenyl)piperidine-2,6-dione B370; (R)-3-(4-((R)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B371; (S)-3-(4-((R)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B372; (R)-3-(4-((R)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B373; (S)-3-(4-((R)-2-((4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)morpholino)phenyl)-3-methylpiperidine-2,6-dione B374; (R)-3-(4-(4-((((S)-4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)morpholin-2-yl)methyl)piperazine-1-yl)phenyl)-3-methylpiperidine-2,6-dione B375; 1-(4-((1-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperidine-4-yl)oxy)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B401; 1-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B402; 1-(2-chloro-4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)-propyl)piperazine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B403; 1-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione B404; 1-(4-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)piperazine-1-yl)2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B405; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B406; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B407; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione B408; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione B409; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-(trifluoromethyl)phenyl)-dihydropyrimidine-2,4(1H,3H)-dione B410; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B411; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2,3-dimethylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B412; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2,4-dimethylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B413; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)2-chloro-3-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B414; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)5-chloro-2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B415; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperazine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B416; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-chloro-5-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B451; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-fluoro-3-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B452; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-fluoro-5-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B453; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-2-chloro-6-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B454; 1-(4-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-3-fluoro-2-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B455; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B456; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B457; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B458; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-fluorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B459; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-fluorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B460; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-methylphenyl)-dihydropyrimidine-2,4(1H,3H)-dione B461; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B462; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)2-chloro-6-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B463; 1-(5-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)4-chloro-2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B464; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)2-chloro-4-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B465; 1-(3-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)4-chloro-2-methylphenyl)dihydropyrimidine-2,4(1H,3H)-dione B466; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B467; 1-(4-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperazine-1-yl)-2-chlorophenyl)-dihydropyrimidine-2,4(1H,3H)-dione B468; 1-(4-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B469; 1-(3-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)piperidine-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione B470; 1-(3-(4-((3-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-3,8-diazabicyclo[3.2.1]octane-8-yl)methyl)piperidine-1-yl)-phenyl)dihydropyrimidine-2,4(1H,3H)-dione B471; 1-(4-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)-2-chlorophenyl)dihydropyrimidine-2,4(1H,3H)-dione B472; 3-(6-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-2-oxoethoxy)-1-methyl-1H-indazole-3-yl)-piperidine-2,6-dione B501; 3-(7-(2-(4-(3-((4-((6-(difluoromethyl)-8-((1R,2S)-2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)piperidine-1-yl)sulfonyl)propyl)-piperazine-1-yl)2-oxoethoxy)-1-methyl-1H-indazole-3-yl)piperidine-2,6-dione B502; 3-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-piperidine-2,6-dione B503; 3-(6-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)-1-methyl-1H-indazole-3-yl)piperidine-2,6-dione B504; 3-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-3-methylpiperidine-2,6-dione B505; 3-(7-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)-1-methyl-1H-indazole-3-yl)piperidine-2,6-dione B506; 3-(6-(4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)-piperidine-2,6-dione B507; 3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)piperidine-2,6-dione B508; (S)-3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-3-methylpiperidine-2,6-dione B509; (R)-3-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-3-methylpiperidine-2,6-dione B510; 3-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)piperidine-2,6-dione B511; 1-(7-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B551; 1-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B552; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-dihydropyrimidine-2,4(1H,3H)-dione B553; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)-dihydropyrimidine-2,4(1H,3H)-dione B554; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-5-fluoro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B555; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-7-fluoro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B556; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-5-fluoro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B557; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-5-chloro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B558; 1-(6-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-7-chloro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B559; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-5-chloro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B560; (S)-1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-2-methylpiperazine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B561; (R)-1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-2-methylpiperazine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B562; (R)-1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-methylpiperazine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B563; 1-(6-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B564; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-6-chloro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B566; 1-(7-(4-((4-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-1-yl)methyl)-4-fluoropiperidine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B567; (S)-1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-methylpiperazine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B568; 1-(7-(2-(1-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)-3-fluoroazetidine-3-yl)ethyl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B569; 1-(6-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)ethyl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B570; 1-(7-(2-(1'-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)-4-fluoro-[1,4'-bipiperidine]-4-yl)ethyl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B571; 1-(7-(4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)piperazine-1-yl)-4-chloro-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B572; 1-(6-(4-(2-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperidine-4-yl)ethyl)piperazine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B573; 1-(6-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethyl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B574; 1-(6-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)piperidine-1-yl)-1-methyl-1H-indazole-3-yl)dihydropyrimidine-2,4(1H,3H)-dione B575; 3-(5-(1-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-2-oxoethyl)piperidine-4-yl)-6-fluoro-1-oxoisoindorin-2-yl)piperidine-2,6-dione B601; 3-(4-((2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-2-oxoethyl)amino)-1-oxoisoindorin-2-yl)-piperidine-2,6-dione B602; 4-((2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione B603; or 3-(5-(1-(4-(2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido-[2,3-d]pyrimidine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)ethoxy)benzyl)piperidine-4-yl)-1-oxo-isoindorin-2-yl)piperidine-2,6-dione B604; Compounds thereof, or their enantiomers, mixtures of enantiomers, diastereomers, mixtures of two or more diastereomers, tautomers, mixtures of two or more tautomers, or isotopic variants; or pharmaceutically acceptable salts, solvates, or hydrates thereof.

18. A pharmaceutical composition comprising a compound according to any one of claims 1 to 17, or an enantiomer thereof, a mixture of enantiomers, a diastereomer, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; and a pharmaceutically acceptable excipient.

19. A pharmaceutical composition comprising a compound according to any one of claims 1 to 17 for use in the treatment, prevention, or improvement of one or more symptoms of a disorder, disease, or condition or proliferative disorder mediated by CDK.

20. The pharmaceutical composition for use according to claim 19, wherein the disorder, disease, or condition mediated by the CDK is mediated by CDK2, CDK4, and / or CDK6; or the proliferative disorder is cancer.

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