Denervation system and method around the subclavian artery

By targeting the subclavian snares for neuromodulation and ablation through percutaneous catheterization, the method addresses the invasive limitations of current treatments, effectively regulating sympathetic innervation to reduce arrhythmia and improve cardiac function.

JP2025521829APending Publication Date: 2025-07-10ARTHA PARTNERS BV
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Patent Information

Application Number
JP2024577266
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-12-06
Filing Date
2023-06-29
Publication Date
2025-07-10

AI Technical Summary

Technical Problem

Current treatments for cardiac arrhythmias, such as atrial fibrillation and ventricular arrhythmias, are invasive, have significant side effects, and do not effectively address the underlying sympathetic nerve signaling that exacerbates these conditions, leading to recurrent arrhythmias and heart failure.

Method used

Targeting the subclavian snares around the subclavian arteries for selective neuromodulation and ablation using percutaneous catheterization, allowing precise regulation of sympathetic innervation to the heart, reducing cardiac electrical heterogeneity and alleviating pathological disease progression.

Benefits of technology

This approach provides a less invasive and more effective method to regulate sympathetic innervation, reducing arrhythmia burden and improving cardiac function by selectively ablating sympathetic nerves, thereby minimizing side effects and enhancing treatment efficacy.

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Abstract

A method for treating a heart disease in a subject includes the step of percutaneously introducing a catheter into the vascular system of the subject. The catheter comprises a neuromodulation element. The neuromodulation element can be positioned on an expansion element. The neuromodulation element of the catheter can be positioned within the left subclavian artery of the subject. At least one of a dorsal subclavian snare or a ventral subclavian snare can be electrically stimulated using the catheter. The method includes the step of confirming the stimulation of the dorsal subclavian snare and / or the ventral subclavian snare by monitoring cardiac parameters. After confirming the stimulation of the dorsal subclavian snare and / or the ventral subclavian snare, ablation energy can be applied to the dorsal subclavian snare and / or the ventral subclavian snare.
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