Non-viral delivery compositions and screening methods
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- BATTELLE MEMORIAL INST
- Filing Date
- 2023-06-09
- Publication Date
- 2026-06-16
AI Technical Summary
Current gene therapy delivery systems, such as adeno-associated virus (AAV) and non-viral systems like liposomes, face challenges in delivering large or multiple payloads to specific tissues while avoiding immune responses and ensuring safety and efficacy, particularly for CRISPR/Cas9 systems.
Development of nucleic acid nanostructure delivery compositions, like DNA origami structures, conjugated with barcodes for high-throughput in vivo screening, enabling targeted and controlled delivery of large gene payloads or small molecule therapeutics by avoiding immune responses and enhancing stability.
The nucleic acid nanostructures provide biocompatible, programmable, and efficient delivery of large gene payloads or small molecule therapeutics, reducing immune responses and improving delivery accuracy and safety.
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