Treatment of Vascular Stenosis

JP2025522832A5Pending Publication Date: 2026-06-22MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH
Filing Date
2023-06-29
Publication Date
2026-06-22

AI Technical Summary

Technical Problem

Chronic vascular stenosis, particularly in arteriovenous fistulas, often leads to restenosis after percutaneous transluminal angioplasty, necessitating repeated and costly procedures, which are ineffective in 50% of cases within six months.

Method used

The use of poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating bindarit, administered in a thermoresponsive hydrogel, is applied directly to the adventitia of blood vessels to inhibit monocyte chemoattractant protein (MCP) polypeptides, reducing stenosis formation and restenosis.

Benefits of technology

The method significantly reduces neointimal hyperplasia and restenosis, enhancing vascular functionality and reducing the need for repeated angioplasty procedures.

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Abstract

This document relates to methods and materials for treating vascular stenosis. For example, nanoparticles (e.g., poly(lactic-co-glycolic acid) (PLGA) nanoparticles) containing one or more inhibitors of monocyte chemoattractant protein (MCP) polypeptides (e.g., bindarit) are provided. In some cases, a composition (e.g., a hydrogel composition) containing one or more nanoparticles containing one or more inhibitors of MCP polypeptides (e.g., bindarit) is placed in direct contact with the adventitia of one or more blood vessels (e.g., one or more blood vessels at risk of stenosis formation) in a mammal (e.g., a mammal that has undergone angioplasty, e.g., a human), so as to reduce or eliminate stenosis formation in the blood vessel(s).
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