Calibration of an imaging system combining optical coherence tomography and visualization modules

Abstract

The imaging system (10, 100, 200) includes a housing assembly (20) having a head unit (18) configured to be at least partially directed toward a target region (16, 116, 216). An optical coherence tomography (OCT) module (14, 114, 214) and a visualization module (12, 112, 212) are disposed in the housing assembly (20) and configured to acquire OCT data and visualization data, respectively, of the target region (16, 116, 216). The system (10, 100, 200) includes a controller (C) configured to generate a scan pattern for a selected calibration region in a calibration target. The OCT data of the calibration region are synchronously acquired. The controller (C) is configured to acquire a projected two-dimensional OCT image of the calibration region based on the OCT data as an inverse mean intensity projection. The controller (C) is configured to register the projected two-dimensional OCT images with corresponding views extracted from the visualization data via a cascaded image registration process having coarse and fine registration stages.

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