Implantable membrane structures and encapsulated devices incorporating same

JP2025532936AInactive Publication Date: 2025-10-03WL GORE & ASSOC INC +1
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Patent Information

Application Number
JP2025518446
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-09-30
Filing Date
2023-09-29
Publication Date
2025-10-03
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing implantable devices face challenges in maintaining a viable population of bioactive entities by minimizing foreign body reactions and preventing the formation of non-functional mesenchymal cells, which can reduce the effectiveness of therapeutic cell populations by occupying space and increasing diffusion barriers.

Method used

Implantable membrane structures with a maximum pore size of less than 2 microns and surface roughness of at least 0.5 microns, comprising layers that reduce mesenchymal cell formation and enhance nutrient access, utilizing materials like fluoropolymer membranes and coatings to support therapeutic cell function.

Benefits of technology

The membrane structures effectively minimize mesenchymal cell formation, ensuring efficient nutrient delivery and maintaining functional cell populations by reducing diffusion barriers and foreign body reactions.

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Abstract

Disclosed is an implantable membrane structure having a maximum pore size (MPS) of less than 2 microns and opposing surfaces, each surface of the structure having a surface roughness (Sa) of greater than about 0.5 microns. When the luminal surface of the implantable membrane structure has a surface roughness (Sa) of greater than about 0.5 microns, mesenchymal cells do not form at the interface between the lumen and the first layer (i.e., the luminal interface), and the mesenchymal cells do not impede the flow of oxygen and nutrients to the graft cells (at the time of implantation). At the time of implantation, the outermost layer of the implantable membrane structure allows for cell infiltration, vascularization, and anchoring of the structure. The implantable membrane structure includes single-layer and multi-layer embodiments. Also provided is an encapsulation device utilizing the implantable membrane structure to encapsulate biological entities (e.g., cells) within a patient.
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Citation Information

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