Intraocular pressure measuring device and intraocular pressure measuring method

Abstract

To provide an intraocular pressure measuring element and an intraocular pressure measuring method.SOLUTION: The tonometer includes a lens body, an annular strain gauge, a plurality of area strain gauges, and a measurement processing circuit. The lens body has a central region and a peripheral region surrounding the central region. The annular strain gauge is disposed in the peripheral region and surrounds the central region. The plurality of area strain gauges are provided at a plurality of predetermined positions in the peripheral area. In response to the intraocular pressure measuring device being mounted on the subject's eye, the measurement processing circuit measures the subject's eye with the ring-shaped strain gauge to obtain first stress data, measures the subject's eye with the plurality of area strain gauges respectively to obtain a plurality of second stress data corresponding to the plurality of predetermined positions, and generates intraocular pressure distribution information based on the first stress data and the plurality of second stress data.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a measuring element and a measuring method, and more particularly to a non-invasive intraocular pressure measuring element and an intraocular pressure measuring method. [Background technology]

[0002] As people work longer hours and use more electronic devices at close range, they are more likely to experience inappropriate symptoms such as eye strain due to overuse and excessive intraocular pressure, which can accelerate eye aging and make people more likely to develop myopia.

[0003] Generally, people with severe myopia, diabetes, or hypertension, or those with a family history of glaucoma, are at high risk of developing glaucoma, and if the condition becomes severe, it can lead to blindness. Therefore, proper monitoring of intraocular pressure is an extremely important part of maintaining eye health.

[0004] Conventional intraocular pressure measurement equipment uses a microelectronic system embedded in a disposable contact lens to measure changes in corneal curvature caused by changes in intraocular pressure. However, with the currently used intraocular pressure measurement method, the corneal curvature and cornea vary irregularly in each individual, resulting in different angles at the corneoscleral junction, which affects the variability of intraocular pressure readings.

[0005] However, in order to accurately evaluate intraocular pressure clinically, it is necessary to accurately obtain pressure changes in each region of the cornea of ​​the eye. Therefore, how to improve intraocular pressure measuring devices and overcome the above-mentioned drawbacks is one of the important issues to be solved in the field. Summary of the Invention [Problem to be solved by the invention]

[0006] The problem to be solved by the present invention is to provide a non-invasive intraocular pressure measuring element that overcomes the drawbacks of the prior art. [Means for solving the problem]

[0007] In order to achieve the above object, the present invention provides an intraocular pressure measuring element including a lens body, an annular strain gauge, a plurality of area strain gauges, and a measurement processing circuit. The lens body has a central region and a peripheral region surrounding the central region. The annular strain gauge is provided in the peripheral region and surrounds the central region. The plurality of area strain gauges are provided at a plurality of predetermined positions in the peripheral region. The measurement processing circuit is electrically connected to the annular strain gauge and the plurality of area strain gauges. In response to the ocular pressure measuring element being mounted (attached) to the eyeball of a subject, the measurement processing circuit is configured to measure the eyeball of the subject with the annular strain gauge to obtain first stress data, measure the eyeball of the subject with the plurality of area strain gauges, respectively, to obtain a plurality of second stress data corresponding to the plurality of predetermined positions, and further generate intraocular pressure distribution information based on the first stress data and the plurality of second stress data.

[0008] To achieve the above object, another aspect of the present invention provides an intraocular pressure measurement method, comprising mounting an intraocular pressure measurement element including a lens body, an annular strain gauge, a plurality of area strain gauges, and a measurement processing circuit on a subject's eyeball. The lens body has a central region and a peripheral region surrounding the central region. The annular strain gauge is provided in the peripheral region and surrounds the central region. The plurality of area strain gauges are provided at a plurality of predetermined positions in the peripheral region. The measurement processing circuit is electrically connected to the annular strain gauge and the plurality of area strain gauges. The intraocular pressure measurement method further comprises configuring (operating) the sensor processing circuit to perform the steps of measuring the subject's eyeball with the annular strain gauge to obtain an absolute pressure value, measuring the subject's eyeball with the plurality of area strain gauges to obtain a plurality of relative pressure difference values ​​corresponding to the plurality of predetermined positions, and generating intraocular pressure distribution information based on the absolute pressure value and the plurality of relative pressure difference values. [Effects of the Invention]

[0009] The present invention has the following beneficial effects: In the intraocular pressure measuring element and intraocular pressure measuring method provided by the present invention, a ring-shaped strain gauge is used to measure the stress value of the main measurement area of ​​the lens body, and a plurality of regional strain gauges are arranged in a ring-shaped array at a plurality of predetermined positions around the subject's eyeball, so that the stress value difference in the areas corresponding to the plurality of predetermined positions can be read and the total stress value can be compensated for, thereby obtaining a more accurate intraocular pressure change value when monitoring the actual intraocular pressure distribution of the subject's eyeball.

[0010] In addition, the present invention uses a flexible capacitive pressure sensor (FCPS) as a ring-shaped strain gauge to measure absolute pressure values ​​in the main measurement area. Therefore, after obtaining multiple relative pressure difference values ​​using the area strain gauge, accurate intraocular pressure distribution information can be generated using the absolute pressure value and multiple relative pressure difference values. In the FCPS, selecting a flexible dielectric layer with a columnar structure can increase the contact area between the dielectric layer and the electrode, thereby improving sensitivity. Selecting and using zinc oxide (ZnO) at the interface between the dielectric layer and the electrode enhances dielectric performance through the Maxwell-Wagner-Sillars polarization effect, thereby improving the performance of the capacitive pressure sensor.

[0011] In order to further understand the features and technical contents of the present invention, please refer to the following detailed description of the present invention and the drawings, but the drawings provided are for reference and explanation only and are not intended to limit the present invention. [Brief explanation of the drawings]

[0012] [Figure 1] FIG. 2 is a functional block diagram of the intraocular pressure measuring element according to the first embodiment of the present invention. [Figure 2] FIG. 1 is a schematic plan view of an intraocular pressure measuring element according to a first embodiment of the present invention. [Figure 3] 1 is a flowchart of an intraocular pressure measurement method according to an embodiment of the present invention. [Figure 4] FIG. 10 is a schematic diagram of intraocular pressure distribution information according to an embodiment of the present invention. [Figure 5] FIG. 2 is a functional block diagram of a measurement processing circuit according to an embodiment of the present invention. [Figure 6] FIG. 10 is a schematic plan view of an intraocular pressure measuring element according to another embodiment of the present invention. [Figure 7] FIG. 7 is a cross-sectional view taken along the line AA in FIG. 6. DETAILED DESCRIPTION OF THE INVENTION

[0013] The following is an implementation mode that describes the "intraocular pressure measuring element and intraocular pressure measuring method" disclosed in the present invention using specific examples, and those skilled in the art can understand the advantages and effects of the present invention from the contents disclosed in this specification. The present invention may be implemented or applied using other specific examples, and each detail in this specification may be variously modified and changed based on different perspectives and applications without departing from the concept of the present invention. It should be noted in advance that the drawings of the present invention are for simple and schematic illustration only and are not drawn to actual size. In the following implementation modes, the technical contents related to the present invention will be described in more detail, but the disclosed contents do not limit the protection scope of the present invention. Furthermore, the term "or" used in this specification may include any one or more combinations of the relevant listed items according to actual circumstances.

[0014] Fig. 1 is a functional block diagram of an intraocular pressure measuring element according to a first embodiment of the present invention, and Fig. 2 is a schematic plan view of the intraocular pressure measuring element according to the first embodiment of the present invention. Referring to Fig. 1 and Fig. 2, the first embodiment of the present invention provides an intraocular pressure measuring element 1 including a lens body 10, an annular strain gauge 12, a plurality of area strain gauges 14, and a measurement processing circuit 16.

[0015] Generally, the lens body 10 is a typical contact lens, made of a polymer (e.g., hydrogel or silicone hydrogel) having a specific shape to correct various vision problems. The lens body 10 has a central region A1 and a peripheral region A2 surrounding the central region A1. In this embodiment, the central region A1 may be, for example, a circular region extending outward from a center point C1 of the lens body 10, and the peripheral region A2 may be, for example, an annular region centered on the center point C1 and extending outward from the circumference of the central region A1.

[0016] In this embodiment, the central region A1 may correspond to a visible portion of the eye, such as the pupil, and the peripheral region A2 may correspond to a non-visible portion of the eye, such as the iris, the portion of the cornea close to the sclera, and the sclera. The central region A1 may be shaped to provide a function for correcting vision defects, which may include myopia (nearsightedness), hyperopia (farsightedness), presbyopia, astigmatism, etc. In some embodiments, the central region A1 may not have a function for correcting vision, and the present invention is not limited thereto.

[0017] The ring-shaped strain gauge 12 and the plurality of area strain gauges 14 may be provided on one surface of the lens body 10 or embedded in the lens body 10. The ring-shaped strain gauge 12 is provided in the peripheral region A2, surrounding the central region A1. The area strain gauges 14 are provided at a plurality of predetermined positions in the peripheral region A2. The plurality of area strain gauges 14 may be arranged in the peripheral region A2 in a ring-shaped array (aligned in a ring shape), or more precisely, they are arranged around the center point C1 of the lens body 10 at equal intervals outside the ring-shaped strain gauge 12. In this embodiment, the number of area strain gauges 14 is eight, but the present invention is not limited to this. Considering an arrangement in which the area strain gauges 14 can perform their most basic functions, at least two area strain gauges 14 must be provided, i.e., the number of area strain gauges 14 must be two or more.

[0018] Furthermore, the measurement processing circuit 16 is electrically connected to the ring strain gauge 12 and the plurality of area strain gauges 14 and may be, for example, an application specific integrated circuit (ASIC) chip capable of signal processing, calculation, communication, and power supply.

[0019] Specifically, the present invention mainly uses a ring-shaped strain gauge 12 to measure the stress value of the main measurement area of ​​the lens body 10, and installs a plurality of area strain gauges 14 in a ring-shaped array at multiple predetermined positions around the subject's eyeball, thereby reading the stress value difference in the areas corresponding to the multiple predetermined positions and compensating for the total stress value, thereby obtaining a more accurate intraocular pressure change value when monitoring the actual intraocular pressure distribution of the subject's eyeball.

[0020] In this embodiment, the ring-shaped strain gauge 12 and the area strain gauges 14 may be, for example, resistive strain gauges, and strain is obtained by detecting changes in resistance. The ring-shaped strain gauge 12 includes a ring-shaped detection element 120 and a lead wire 122, and each area strain gauge 14 includes an area detection element 140 and a lead wire 142. The ring-shaped strain gauge 12 may be disposed inside a plurality of area strain gauges 14, i.e., the distance between the ring-shaped strain gauge 12 and the center point C1 is smaller than the distance between each area strain gauge 14 and the center point C1.

[0021] In this embodiment, the ring-shaped strain gauge 12 and the area strain gauge 14 are designed with different strain coefficients. For example, each area strain gauge 14 has a first strain coefficient, and the ring-shaped strain gauge 12 has a second strain coefficient, with the first strain coefficient being greater than the second strain coefficient. Specifically, a higher strain coefficient indicates a higher sensitivity of the mechanism for sensing tension or deformation. Therefore, the ring-shaped strain gauge 12 is made of a low-strain-coefficient material, while the area strain gauge 14 is made of a high-strain-coefficient material. This allows for monitoring intraocular pressure differences in different areas of the subject's eye and reduces intraocular pressure detection errors caused by irregular changes in the cornea. In some embodiments, the ring-shaped sensing element 120 is made of an alloy material such as nickel-chromium or platinum, and the area sensing element 140 is made of a semiconductor material such as graphite, a carbon tube, or a transition metal material such as tin(II) selenide (SnSe), molybdenum disulfide (MoS), or tungsten diselenide (WSe).

[0022] 3, which is a flowchart of the intraocular pressure measurement method according to the embodiment of the present invention. As shown in the figure, the intraocular pressure measurement method according to the embodiment includes the following steps:

[0023] In step S10, the intraocular pressure measuring element is mounted on the eyeball of the subject.

[0024] Measurement processing circuitry 16 is configured to perform the following steps.

[0025] In step S11, the eyeball of the subject is measured by the ring-shaped strain gauge 12 to obtain first stress data.

[0026] In step S11, the strain can be obtained by detecting the resistance value of the ring-shaped detection component 120, and the total resistance measured is the intraocular pressure converted by the total area after all the eyeballs are distorted.

[0027] In step S12, the eyeball of the subject is measured using the plurality of area strain gauges 14 to obtain a plurality of second stress data corresponding to a plurality of predetermined positions. For example, each area strain gauge 14 may perform measurement at a corresponding predetermined position for a predetermined period, and the stress difference value generated during this predetermined period may be observed as the second stress data.

[0028] In step S13, intraocular pressure distribution information is generated based on the first stress data and the plurality of second stress data.

[0029] Referring to FIG. 4, FIG. 4 is a schematic diagram of intraocular pressure distribution information according to an embodiment of the present invention.

[0030] 4, after obtaining the total stress value measured by the regional strain gauges 14, the stress values ​​of multiple regions are obtained by compensation using the stress difference values ​​obtained by each regional strain gauge 14, and then converted to obtain the intraocular pressure distribution. Therefore, regardless of how irregular the corneal curvature and cornea of ​​each individual may change, the intraocular pressure measuring element of the present invention can accurately reflect the changes in intraocular pressure in each region.

[0031] 5, which is a functional block diagram of a measurement processing circuit according to an embodiment of the present invention. As shown in FIG. 5, the measurement processing circuit 16 includes a multiplexer 160, an analog-to-digital converter 162, a processing control circuit 164, and a signal transmission circuit 166.

[0032] The multiplexer 160 may be electrically connected to the ring strain gauge 12 and the plurality of area strain gauges 14 and may be controlled and switched by the processing control circuit 164 to select one or more of the ring strain gauge 12 and the plurality of area strain gauges 14 as input sources for stress values. The analog-to-digital converter 162 converts the signals from the ring strain gauge 12 and the plurality of area strain gauges 14. For example, the analog-to-digital converter 162 may transmit voltage signals generated by the ring strain gauge 12 and the plurality of area strain gauges 14 to the processing control circuit 164 in a digital signal format.

[0033] The processing control circuit 164 may be, for example, a processor for processing the converted signals (digital signals) of the ring strain gauge 12 and the multiple area strain gauges 14 to obtain first stress data and multiple second stress data, and performing processing to generate intraocular pressure distribution information.

[0034] 1, the intraocular pressure measuring device 1 further includes an antenna assembly 18 having a ring shape and surrounding the central region A1. The antenna assembly 18 is electrically connected to the measurement processing circuit 16, is provided in the peripheral region A2, and performs data transmission with an external device. In this embodiment, the ring-shaped strain gauge 12, the multiple area strain gauges 14, and the antenna assembly 18 do not overlap with each other in the normal direction of the lens body 10 to prevent interference.

[0035] The signal transmission circuit 166 in the measurement processing circuit 16 is electrically connected to the antenna assembly 18 and receives data from the antenna assembly 18 or transmits intraocular pressure distribution information to the antenna assembly 18. The signal transmission circuit 166 and the antenna assembly 18 may communicate with various electronic devices for various applications. For example, in another embodiment of the present invention (not shown), the tonometry element 1 may be wirelessly connected to any wearable device worn by the user (e.g., a reader attached to glasses or a neck-worn reader), and the wearable device (or reader) may employ a common wireless transmission technology such as RFID or other wireless induction technology of electrical energy to power, sense, or provide signal feedback to the tonometry element 1.

[0036] 6 and 7, Fig. 6 is a schematic plan view of an intraocular pressure measuring device 1' according to another embodiment of the present invention, and Fig. 7 is a schematic cross-sectional view taken along the cross-sectional line AA in Fig. 6. In this embodiment, the ring-shaped strain gauge 12' is a flexible capacitive pressure sensor (FCPS) including a bottom electrode layer 120', a flexible dielectric layer 122', and a top electrode layer 124'. The flexible dielectric layer 122' is provided on the bottom electrode layer 120', and the top electrode layer 124' is provided on the flexible dielectric layer 122'.

[0037] In the capacitive pressure sensor employed in this embodiment, a flexible dielectric layer 122' is disposed between the top electrode layer 124' and the bottom electrode layer 120'. When an external force is applied to the sensor, the flexible dielectric layer 122' undergoes elastic deformation, reducing the inter-electrode distance and increasing the total capacitance.

[0038] The flexible dielectric layer 122' also includes a plurality of elastic columns FC spaced apart from one another along the circumferential direction D1 of the peripheral region A2. The height of the elastic columns FC is preferably 0.1 μm to 2 μm, and the width of the elastic columns FC is preferably 100 nm to 1000 nm. The elastic columns FC may be made of polydimethylsiloxane (PDMS) polymer. Selecting a columnar flexible dielectric layer 122' ensures a large contact area between the dielectric layer and the electrodes, and the FCPS formed with the above configuration has high sensitivity in both the ultra-low pressure range and the high pressure range. Here, the ultra-low pressure range is preferably 130 Pa to 6700 Pa, and the high pressure range is preferably 67000 Pa to 102000 Pa.

[0039] Meanwhile, the bottom electrode layer 120' and the top electrode layer 124' may have a stacked structure. For example, the bottom electrode layer 120' may include a first transparent conductive layer E1 and a second transparent conductive layer E2 disposed on the first transparent conductive layer E1, and the top electrode layer 124' may include a third transparent conductive layer E3 and a fourth transparent conductive layer E4 disposed on the third transparent conductive layer E3. The second transparent conductive layer E2 and the third transparent conductive layer E3 may be made of zinc oxide (ZnO), and the first transparent conductive layer E1 and the fourth transparent conductive layer E4 may be made of indium tin oxide (ITO). It should be noted that zinc oxide is easily polarized under an external electric field, which enhances its dielectric properties through the Maxwell-Wagner-Schiller polarization effect and improves the performance of the capacitive pressure sensor. Furthermore, when the second transparent conductive layer E2 and the third transparent conductive layer E3 are made of zinc oxide, they have high transmittance, making the thin film structure transparent.

[0040] Based on the above configuration, when an FCPS is used as the ring-shaped strain gauge 12', the measured first stress data is an absolute pressure value. Furthermore, when the intraocular pressure measuring element 1' is mounted on the subject's eyeball, for example, the intraocular pressure measuring element 1' bends in accordance with the curvature of the cornea. As the intraocular pressure increases, the radius of curvature of the intraocular pressure measuring element 1' increases accordingly, and the degree of bending also changes accordingly. Since the capacitance value of the FCPS changes in accordance with changes in the intraocular pressure of the subject's eyeball, changes in intraocular pressure can be monitored in real time. Therefore, after acquiring multiple relative pressure difference values ​​using the area strain gauge 14, the measurement processing circuit 16 compensates for the absolute pressure value of the main measurement area based on the multiple relative pressure difference values, thereby generating more accurate intraocular pressure distribution information.

[0041] [Beneficial Effects of Examples] The present invention has the following beneficial effects: In the intraocular pressure measuring element and intraocular pressure measuring method provided by the present invention, a ring-shaped strain gauge is used to measure the stress value of the main measurement area of ​​the lens body, and a plurality of regional strain gauges are arranged in a ring-shaped array at a plurality of predetermined positions around the subject's eyeball, so that the stress value difference in the areas corresponding to the plurality of predetermined positions can be read and the total stress value can be compensated for, thereby obtaining a more accurate intraocular pressure change value when monitoring the actual intraocular pressure distribution of the subject's eyeball.

[0042] In addition, the present invention uses an FCPS as a ring-shaped strain gauge to measure the absolute pressure value of the main measurement area. Therefore, after obtaining multiple relative pressure difference values ​​using the area strain gauge, accurate intraocular pressure distribution information can be generated using the absolute pressure value and the multiple relative pressure difference values. In the FCPS, selecting a flexible dielectric layer with a columnar structure can maintain a large contact area between the dielectric layer and the electrode, thereby improving sensitivity. Selecting and using zinc oxide at the interface between the dielectric layer and the electrode enhances dielectric performance due to the Maxwell-Wagner-Schiller polarization effect, thereby improving the performance of the capacitive pressure sensor.

[0043] The contents disclosed above are merely preferred and possible embodiments of the present invention, and do not limit the scope of the claims of the present invention. Therefore, any equivalent technical modifications made using the contents of the specification and drawings of the present invention are included within the scope of the claims of the present invention.

[0044] [Note] [Appendix 1] a lens body having a central region and a peripheral region surrounding the central region; a ring-shaped strain gauge provided in the peripheral region and surrounding the central region; a plurality of area strain gauges provided at a plurality of predetermined positions in the peripheral area; a measurement processing circuit electrically connected to the ring strain gauge and the plurality of area strain gauges; In response to being mounted on the eyeball of a subject, the measurement processing circuit is configured to measure the eyeball of the subject using the ring-shaped strain gauge to obtain first stress data, and to measure the eyeball of the subject using the plurality of area strain gauges to obtain a plurality of second stress data corresponding to the plurality of predetermined positions, and further to generate intraocular pressure distribution information based on the first stress data and the plurality of second stress data.

[0045] [Appendix 2] the central region is circular and the peripheral region is annular; The intraocular pressure measuring element according to claim 1, wherein the plurality of area strain gauges are arranged in a ring-shaped array in the peripheral region, and the number of the plurality of area strain gauges is two or more.

[0046] [Appendix 3] The intraocular pressure measuring element according to Appendix 2, wherein the plurality of area strain gauges are arranged around the outside of the annular strain gauge at equal intervals, with the center of the lens body as the axis.

[0047] [Appendix 4] 2. The intraocular pressure measuring element of claim 1, wherein each of the plurality of area strain gauges has a first strain coefficient, and the ring-shaped strain gauge has a second strain coefficient, the first strain coefficient being greater than the second strain coefficient.

[0048] [Appendix 5] The intraocular pressure measuring element of Appendix 4, wherein the ring-shaped strain gauge includes a ring-shaped detection component made of an alloy material, and each of the plurality of area strain gauges includes an area detection component made of a semiconductor material.

[0049] [Appendix 6] 2. The intraocular pressure measuring element of claim 1, wherein the ring-shaped strain gauge is a flexible capacitive pressure sensor including a bottom electrode layer, a flexible dielectric layer provided on the bottom electrode layer, and a top electrode layer provided on the flexible dielectric layer.

[0050] [Appendix 7] the peripheral region is annular; 7. The intraocular pressure measuring element according to claim 6, wherein the flexible dielectric layer includes a plurality of elastic pillars spaced apart from one another along the circumferential direction of the peripheral region.

[0051] [Appendix 8] the bottom electrode layer includes a first transparent conductive layer and a second transparent conductive layer disposed on the first transparent conductive layer; 8. The intraocular pressure measuring element of claim 7, wherein the top electrode layer includes a third transparent conductive layer and a fourth transparent conductive layer disposed on the third transparent conductive layer.

[0052] [Appendix 9] the second transparent conductive layer and the third transparent conductive layer contain zinc oxide; the first transparent conductive layer and the fourth transparent conductive layer comprise indium tin oxide; 9. The intraocular pressure measuring element according to claim 8, wherein each of the plurality of elastic rods comprises a polydimethylsiloxane polymer.

[0053] [Appendix 10] the first stress data is an absolute pressure value, and the plurality of second stress data is a plurality of relative pressure difference values; The intraocular pressure measuring element according to claim 6, wherein the measurement processing circuit further generates intraocular pressure distribution information based on the absolute pressure value and the plurality of relative pressure difference values.

[0054] [Appendix 11] The intraocular pressure measuring element described in Appendix 1 further includes an antenna assembly electrically connected to the measurement processing circuit, provided in the peripheral region, and for data transmission with an external device.

[0055] [Appendix 12] The measurement processing circuit a multiplexer electrically connected to the ring strain gauge and the plurality of area strain gauges; an analog-to-digital converter for converting signals from the ring strain gauge and the plurality of area strain gauges; a processing control circuit for processing the converted signals of the ring strain gauge and the plurality of area strain gauges to obtain the first stress data and the plurality of second stress data, and for processing to generate the intraocular pressure distribution information; and a signal transmission circuit for receiving data by the antenna assembly or transmitting the intraocular pressure distribution information.

[0056] [Appendix 13] 12. The intraocular pressure measuring element according to claim 11, wherein the antenna assembly has a ring shape and is arranged to surround the central region.

[0057] [Appendix 14] The intraocular pressure measuring element of claim 13, wherein the ring-shaped strain gauge, the plurality of area strain gauges, and the antenna assembly do not overlap with each other in the normal direction of the lens body.

[0058] [Appendix 15] mounting an intraocular pressure measuring element on the eyeball of a subject, the intraocular pressure measuring element comprising: a lens body having a central region and a peripheral region surrounding the central region; a ring-shaped strain gauge provided in the peripheral region and surrounding the central region; a plurality of area strain gauges provided at a plurality of predetermined positions in the peripheral region; and a measurement processing circuit electrically connected to the ring-shaped strain gauge and the plurality of area strain gauges; By configuring the measurement processing circuit, measuring the eyeball of the subject with the ring-shaped strain gauge to obtain first stress data; measuring the eyeball of the subject with the plurality of area strain gauges to obtain a plurality of second stress data corresponding to the plurality of predetermined positions; generating intraocular pressure distribution information based on the first stress data and the plurality of second stress data.

[0059] [Appendix 16] 16. The intraocular pressure measurement method of claim 15, wherein the central region is circular, the peripheral region is annular, the plurality of area strain gauges are arranged in an annular array in the peripheral region, the number of the plurality of area strain gauges is two or more, and the plurality of area strain gauges are arranged around the outside of the annular strain gauge at equal intervals, with the center of the lens body as the axis.

[0060] [Appendix 17] each of the plurality of area strain gauges has a first strain coefficient and the ring strain gauge has a second strain coefficient, the first strain coefficient being greater than the second strain coefficient; the ring-shaped strain gauge includes a ring-shaped detection component made of an alloy material; 16. The method for measuring intraocular pressure described in Appendix 15, wherein each of the plurality of area strain gauges includes an area detection component made from a semiconductor material.

[0061] [Appendix 18] the ring-shaped strain gauge is a flexible capacitive pressure sensor including a bottom electrode layer, a flexible dielectric layer provided on the bottom electrode layer, and a top electrode layer provided on the flexible dielectric layer; the peripheral region is annular; the flexible dielectric layer includes a plurality of elastic pillars spaced apart from one another along a circumferential direction of the peripheral region; the bottom electrode layer includes a first transparent conductive layer and a second transparent conductive layer disposed on the first transparent conductive layer; the top electrode layer includes a third transparent conductive layer and a fourth transparent conductive layer disposed on the third transparent conductive layer; the second transparent conductive layer and the third transparent conductive layer contain zinc oxide; the first transparent conductive layer and the fourth transparent conductive layer comprise indium tin oxide; 16. The method of measuring intraocular pressure described in Appendix 15, wherein each of the plurality of elastic rods comprises a polydimethylsiloxane polymer.

[0062] [Appendix 19] the first stress data is an absolute pressure value, and the plurality of second stress data is a plurality of relative pressure difference values; 16. The intraocular pressure measurement method according to claim 15, wherein the measurement processing circuit further generates intraocular pressure distribution information based on the absolute pressure value and the plurality of relative pressure difference values.

[0063] [Appendix 20] the intraocular pressure measuring element further includes an antenna assembly electrically connected to the measurement processing circuit, provided in the peripheral area, for transmitting data to an external device; The measurement processing circuit a multiplexer electrically connected to the ring strain gauge and the plurality of area strain gauges; an analog-to-digital converter for converting signals from the ring strain gauge and the plurality of area strain gauges; a processing control circuit for processing the converted signals of the ring strain gauge and the plurality of area strain gauges to obtain the first stress data and the plurality of second stress data, and for processing to generate the intraocular pressure distribution information; and a signal transmission circuit for receiving data by the antenna assembly or transmitting the intraocular pressure distribution information. [Explanation of symbols]

[0064] 1, 1': intraocular pressure measuring element 10: Lens body 12, 12': Annular strain gauge 14: Area strain gauge 16: Measurement processing circuit 18: Antenna assembly 120: Ring-shaped detection part 120': Bottom electrode layer 122, 142: Conductor 122': Flexible dielectric layer 124': Top electrode layer 140: Area detection component 160: Multiplexer 162: Analog-to-digital converter 164: Processing control circuit 166: Signal transmission circuit A1: Central area A2: Peripheral area C1: Center point D1: Circumferential direction E1: First transparent conductive layer E2: Second transparent conductive layer E3: Third transparent conductive layer E4: Fourth transparent conductive layer FC: Elastic column S10~S13: Step

Claims

1. a lens body having a central region and a peripheral region surrounding the central region; a ring-shaped strain gauge provided in the peripheral region and surrounding the central region; a plurality of area strain gauges provided at a plurality of predetermined positions in the peripheral area; a measurement processing circuit electrically connected to the ring strain gauge and the plurality of area strain gauges; In response to being mounted on the eyeball of a subject, the measurement processing circuit is configured to measure the eyeball of the subject using the ring-shaped strain gauge to obtain first stress data, and to measure the eyeball of the subject using the plurality of area strain gauges to obtain a plurality of second stress data corresponding to the plurality of predetermined positions, and further to generate intraocular pressure distribution information based on the first stress data and the plurality of second stress data.

2. the central region is circular and the peripheral region is annular; The intraocular pressure measuring element according to claim 1 , wherein the plurality of area strain gauges are arranged in an annular array in the peripheral region, and the number of the plurality of area strain gauges is two or more.

3. 3. The intraocular pressure measuring element according to claim 2, wherein the plurality of area strain gauges are provided around the outside of the ring-shaped strain gauge at equal intervals, with the center of the lens body as an axis.

4. 2. The intraocular pressure measuring element according to claim 1, wherein each of the plurality of area strain gauges has a first strain coefficient and the ring strain gauge has a second strain coefficient, the first strain coefficient being greater than the second strain coefficient.

5. The intraocular pressure measuring element according to claim 4 , wherein the ring-shaped strain gauge includes a ring-shaped detection component made of an alloy material, and each of the plurality of area strain gauges includes an area detection component made of a semiconductor material.

6. 2. The intraocular pressure measuring element according to claim 1, wherein the ring-shaped strain gauge is a flexible capacitive pressure sensor including a bottom electrode layer, a flexible dielectric layer provided on the bottom electrode layer, and a top electrode layer provided on the flexible dielectric layer.

7. the peripheral region is annular; The intraocular pressure measuring element according to claim 6 , wherein the flexible dielectric layer includes a plurality of elastic pillars spaced apart from one another along the circumferential direction of the peripheral region.

8. the bottom electrode layer includes a first transparent conductive layer and a second transparent conductive layer disposed on the first transparent conductive layer; The tonometry element according to claim 7 , wherein the top electrode layer includes a third transparent conductive layer and a fourth transparent conductive layer provided on the third transparent conductive layer.

9. the second transparent conductive layer and the third transparent conductive layer contain zinc oxide; the first transparent conductive layer and the fourth transparent conductive layer comprise indium tin oxide; The tonometry element according to claim 8 , wherein each of the plurality of elastic rods comprises a polydimethylsiloxane polymer.

10. the first stress data is an absolute pressure value, and the plurality of second stress data is a plurality of relative pressure difference values; The intraocular pressure measuring element according to claim 6 , wherein the measurement processing circuit further generates intraocular pressure distribution information based on the absolute pressure value and the plurality of relative pressure difference values.

11. The intraocular pressure measuring element according to claim 1 , further comprising an antenna assembly electrically connected to the measurement processing circuit, provided in the peripheral area, for transmitting data to an external device.

12. The measurement processing circuit a multiplexer electrically connected to the ring strain gauge and the plurality of area strain gauges; an analog-to-digital converter for converting signals from the ring strain gauge and the plurality of area strain gauges; a processing control circuit for processing the converted signals of the ring strain gauge and the plurality of area strain gauges to obtain the first stress data and the plurality of second stress data, and for processing to generate the intraocular pressure distribution information; The tonometry element according to claim 11 , further comprising: a signal transmission circuit for receiving data by the antenna assembly or transmitting the intraocular pressure distribution information.

13. The tonometry element according to claim 11 , wherein the antenna assembly has an annular shape and is provided surrounding the central region.

14. The intraocular pressure measuring element according to claim 13 , wherein the ring-shaped strain gauge, the plurality of area strain gauges and the antenna assembly do not overlap with each other in a normal direction of the lens body.

15. mounting an intraocular pressure measuring element on the eyeball of a subject, the intraocular pressure measuring element comprising: a lens body having a central region and a peripheral region surrounding the central region; a ring-shaped strain gauge provided in the peripheral region and surrounding the central region; a plurality of area strain gauges provided at a plurality of predetermined positions in the peripheral region; and a measurement processing circuit electrically connected to the ring-shaped strain gauge and the plurality of area strain gauges; By configuring the measurement processing circuit, measuring the eyeball of the subject with the ring-shaped strain gauge to obtain first stress data; measuring the eyeball of the subject with the plurality of area strain gauges to obtain a plurality of second stress data corresponding to the plurality of predetermined positions; generating intraocular pressure distribution information based on the first stress data and the plurality of second stress data.

16. 16. The intraocular pressure measurement method according to claim 15, wherein the central region is circular, the peripheral region is annular, the plurality of area strain gauges are arranged in an annular array in the peripheral region, the number of the plurality of area strain gauges is two or more, and the plurality of area strain gauges are arranged around the outside of the annular strain gauge at equal intervals, with the center of the lens body as an axis.

17. each of the plurality of area strain gauges has a first strain coefficient and the ring strain gauge has a second strain coefficient, the first strain coefficient being greater than the second strain coefficient; the ring-shaped strain gauge includes a ring-shaped detection component made of an alloy material; 16. The method of claim 15, wherein each of the plurality of area strain gauges includes an area detection component made from a semiconductor material.

18. the ring-shaped strain gauge is a flexible capacitive pressure sensor including a bottom electrode layer, a flexible dielectric layer provided on the bottom electrode layer, and a top electrode layer provided on the flexible dielectric layer; the peripheral region is annular; the flexible dielectric layer includes a plurality of elastic pillars spaced apart from one another along a circumferential direction of the peripheral region; the bottom electrode layer includes a first transparent conductive layer and a second transparent conductive layer disposed on the first transparent conductive layer; the top electrode layer includes a third transparent conductive layer and a fourth transparent conductive layer disposed on the third transparent conductive layer; the second transparent conductive layer and the third transparent conductive layer contain zinc oxide; the first transparent conductive layer and the fourth transparent conductive layer comprise indium tin oxide; 16. The method of claim 15, wherein each of the plurality of elastic rods comprises a polydimethylsiloxane polymer.

19. the first stress data is an absolute pressure value, and the plurality of second stress data is a plurality of relative pressure difference values; The intraocular pressure measurement method according to claim 15 , wherein the measurement processing circuit further generates intraocular pressure distribution information based on the absolute pressure value and the plurality of relative pressure difference values.

20. the intraocular pressure measuring element further includes an antenna assembly electrically connected to the measurement processing circuit, provided in the peripheral area, for transmitting data to an external device; The measurement processing circuit a multiplexer electrically connected to the ring strain gauge and the plurality of area strain gauges; an analog-to-digital converter for converting signals from the ring strain gauge and the plurality of area strain gauges; a processing control circuit for processing the converted signals of the ring strain gauge and the plurality of area strain gauges to obtain the first stress data and the plurality of second stress data, and for processing to generate the intraocular pressure distribution information; 16. The method for measuring intraocular pressure according to claim 15, further comprising: a signal transmission circuit for receiving data by the antenna assembly or transmitting the intraocular pressure distribution information.

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