Oral composition

Abstract

To provide a composition for the oral cavity, having excellent balance between cushioning properties in brushing teeth and ease of spreading to the teeth and gums.SOLUTION: An oral composition comprising an abrasive and a binder, wherein the residual ratio in a water-containing state is 60% or more and 180% or less.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Patent Documents 1 and 2 describe techniques for improving the solubility and residual properties of oral compositions. Patent Document 1 (JP 2021-523142 A) relates to an oral care composition, such as an oral care composition and / or a dentifrice composition, that may be residue-free without sacrificing the oral health benefits typically provided by a user's brushing (paragraph 0004), and describes a unit-dose oral care composition that has a total dissolution time per dose of less than about 1,000 seconds when measured using a specific method (claim 1, paragraph 0005).

[0003] Patent Document 2 (JP 2014-129305 A) describes a toothpaste composition in a tube container that contains specific amounts of cetylpyridinium chloride, specific amounts of calcium carbonate, abrasive silica, and water, and that has a total content of calcium carbonate and abrasive silica within a specific range, as well as a pH (Claim 1). The document states that this composition leaves teeth feeling smooth after brushing with a toothbrush or the like, while providing a refreshing feeling with little powder remaining in the mouth, and that it can effectively prevent the amount of cetylpyridinium chloride from decreasing, thereby enabling the composition to fully exert its excellent antibacterial activity (paragraph 0009). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Special Publication No. 2021-523142 [Patent Document 2] Japanese Patent Application Laid-Open No. 2014-129305 DISCLOSURE OF THE INVENTION [Problem to be solved by the invention]

[0005] Through the research of the present inventors, it became clear that there is room for improvement in the products described in the above patent documents in terms of improving cushioning properties when brushing teeth while also making it easier to spread to the teeth and gums.

[0006] The present invention provides an oral composition that has an excellent balance between cushioning properties during tooth brushing and ease of spreading over teeth and gums. [Means for solving the problem]

[0007] According to the present invention, the following oral compositions are provided. [1] An oral composition comprising an abrasive and a binder, An oral composition having a residual rate when wet of 60% or more and 180% or less, as measured by the following method 1. (Method 1) 1. Weigh 2.0 g of the oral composition and 10 g of water into a 30 mL beaker. Record the amount of the oral composition [g]. 2. Place a stirring bar in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds. 3. After stirring, the contents of the beaker are transferred onto a nylon mesh with a pore size of 100 μm and allowed to stand for 30 seconds. 4. The amount of residue [g] on the nylon mesh is weighed, and the residual rate when wet is calculated based on the following formula (1). Residual rate when wet (%)=100*residue amount / weighed amount (1) [2] The oral composition according to [1], wherein the binder contains thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The oral composition described in [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan). [5] An oral composition described in any one of [1] to [4], further comprising a humectant. [6] An oral composition described in any one of [1] to [5], wherein the abrasive contains abrasive silica. [7] An oral composition described in any one of [1] to [6], which is a dentifrice composition. [8] The oral composition according to any one of [1] to [7], which is a toothpaste composition. [9] A dentifrice in which the oral composition described in any one of [1] to [8] is filled in a tube container.

[0008] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention. [Effects of the Invention]

[0009] According to the present invention, an oral composition can be obtained that has an excellent balance between cushioning properties during tooth brushing and ease of spreading over teeth and gums. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component either alone or in combination of two or more. In this specification, the symbol "to" indicating a numerical range means "greater than or equal to" or "less than or equal to," and both of the numerical values ​​at both ends are included.

[0011] (Oral composition) In this embodiment, the oral composition contains an abrasive and a binder, and has a water retention rate of 60% or more and 180% or less, as measured by the following method 1. (Method 1) 1. Weigh 2.0 g of the oral composition and 10 g of water into a 30 mL beaker. Record the amount of the oral composition [g]. 2. Place a stirring bar in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds. 3. After stirring, transfer the contents of the beaker onto a nylon mesh with a pore size of 100 μm and leave it to stand for 30 seconds. 4. Weigh the amount of residue [g] on the nylon mesh and calculate the residual rate when wet based on the following formula (1). Residual rate when wet (%)=100*residue amount / weighed amount (1)

[0012] In Method 1, the temperature for measuring the residual rate when wet is specifically 25°C. In step 1 of method 1, the weighed amount is specifically in the range of 1.95 g to 2.04 g, and preferably in the range of 1.98 g to 2.02 g. In step 3 of Method 1, leave the nylon mesh to stand for 30 seconds, from the point where the filtrate stops dripping.

[0013] The present inventors have investigated the ingredients and properties of oral compositions as design guidelines for improving the balance between cushioning properties during tooth brushing and ease of spread to teeth and gums. As a result, they have newly discovered that by controlling the ingredients of an oral composition and using the residual rate when wet as an indicator, it is possible to impart suitable cushioning properties to the surfaces of teeth and gums during tooth brushing and improve the ease of spread of the oral composition over teeth and gums, thereby achieving a favorable balance of these effects. Here, the residual ratio when hydrated is considered to be an index that combines the proportion of the oral composition that disperses or dissolves in water and the proportion of the oral composition that encapsulates or swells in water when the oral composition comes into contact with water. In this embodiment, by controlling the residual ratio when hydrated of an oral composition that contains a combination of an abrasive and a binder, it is possible to achieve an excellent balance between cushioning properties during toothbrushing and ease of application of the oral composition to teeth and gums. This also makes it possible to obtain an oral composition that provides an excellent feel when used in the oral cavity. For example, when using the oral composition with a toothbrush, it is possible to provide a moderate massaging sensation with the toothbrush while reducing irritation.

[0014] The residual rate when hydrated is 60% or more, preferably 100% or more, more preferably 110% or more, and even more preferably 120% or more, thereby improving cushioning properties when brushing teeth. Furthermore, in order to improve the ease with which the oral composition can be spread over the teeth and gums, the residual rate when wet is 180% or less, preferably 170% or less, more preferably 150% or less, and even more preferably 135% or less, which can, for example, prevent uneven distribution of the oral composition in the oral cavity, making it easier to spread evenly, and also improving the durability of the oral composition in the oral cavity. Here, as mentioned above, the residual rate when hydrated is an indicator that includes oral compositions that encapsulate water or swell in water, and therefore, in oral compositions that swell to a large extent when hydrated, the value can exceed 100%.

[0015] Next, the components of the oral composition will be described. The oral composition includes an abrasive and a binder as described above.

[0016] (abrasive) Examples of abrasives include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel-process silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolite; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, and quaternary calcium phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0017] The abrasive preferably contains abrasive silica, more preferably hydrated silicic acid. It is also preferable that the abrasive contains anhydrous silicic acid. This allows for a more stable improvement in the balance between cushioning properties during tooth brushing and ease of application of the oral composition to teeth and gums. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0018] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, and even more preferably 5 μm or more, which allows for efficient removal of stains from the tooth surface. The average particle size of the abrasive silica is preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less, thereby making it possible to obtain an oral composition that is smooth to the touch.

[0019] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering particle size distribution analyzer. 50 It can be said that:

[0020] It is also preferable that the abrasive is substantially free of calcium carbonate, which makes it possible to more stably improve the balance between cushioning properties during tooth brushing and ease of spreading of the oral composition over the teeth and gums. Here, the oral composition not containing calcium carbonate specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001% by mass or less of the entire oral composition.

[0021] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably more than 10% by mass, still more preferably more than 10% by mass, even more preferably more than 11% by mass, and still more preferably more than 13% by mass, based on the total mass of the oral composition. This allows for efficient removal of stains from tooth surfaces. The content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total mass of the oral composition, thereby providing an oral composition with excellent smoothness in use.

[0022] (binder) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel-process silica and precipitated silica) and anhydrous silicic acid (e.g., gel-process silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0023] The binder preferably includes an inorganic binder, and more preferably includes thickening silica, which can more stably improve the balance between cushioning properties during tooth brushing and ease of spreading of the oral composition over the teeth and gums.

[0024] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica. The average particle size of the thickening silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more, which allows the viscosity of the oral composition to be maintained more efficiently. The average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less, thereby making it possible to obtain an oral composition that is excellent in smoothness when used.

[0025] The oil absorption of the thickening silica, determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0026] The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This allows for an oral composition with superior cushioning properties during tooth brushing. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc. The content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total mass of the oral composition, thereby enabling the production of an oral composition with excellent surface smoothness.

[0027] The binder preferably includes an organic binder. When the binder includes thickening silica, it is preferable that the binder further includes an organic binder. This allows for a more stable improvement in the balance between cushioning properties during tooth brushing and ease of spreading of the oral composition over the teeth and gums.

[0028] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymers, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); More preferably, it contains one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; More preferably, the compound contains two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; Even more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; Even more preferably, it contains sodium alginate and xanthan gum. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0029] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition does not contain xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

[0030] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total mass of the oral composition, which allows the oral composition to have an appropriate viscosity. The content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total mass of the oral composition. This allows for an oral composition that, when filled in a tube container, is easily squeezed out of the tube container.

[0031] The mass ratio of the organic binder content to the inorganic binder content in the oral composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more, thereby making it possible to obtain an oral composition that is smooth to the touch and has an excellent feel when used. The mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less, thereby providing an oral composition that is easy to dispense from a tube or other container onto a toothbrush or the like.

[0032] The total content of the binder in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition, which allows the oral composition to have an appropriate viscosity. The total content of the binder in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows for an oral composition that is more easily absorbed by saliva during tooth brushing. Furthermore, excessive thickening of the oral composition can be suppressed.

[0033] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total mass of the oral composition, thereby making it possible to appropriately suppress the fluidity of the oral composition. The total silica content in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition, which allows for an oral composition that is more easily mixed with saliva in the oral cavity, for example, during tooth brushing.

[0034] (Other ingredients) The oral composition may further contain ingredients other than those mentioned above, such as medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., which may be selected appropriately depending on the dosage form.

[0035] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0036] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0037] Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0038] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0039] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0040] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0041] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0042] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0043] An example of a plaque decomposing enzyme is dextranase.

[0044] The thickening agent may be, for example, a commercially available ingredient for pharmaceuticals, foods, or cosmetics. The thickening agent may include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically, sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactite, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0045] Examples of surfactants include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; Nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and Examples thereof include one or more selected from the group consisting of amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amide alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may be a foaming agent.

[0046] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total mass of the oral composition, thereby providing an oral composition that foams appropriately when brushing teeth. The content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total mass of the oral composition, thereby providing an oral composition with cleansing power that does not excessively remove oil from the oral cavity.

[0047] The oral composition preferably further comprises a humectant, which can provide the oral composition with better manufacturing stability. The humectant may be any commercially available ingredient for pharmaceuticals, foods, or cosmetics, such as polyhydric alcohols, and more specifically, may be one or more selected from the group consisting of sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0048] In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, more preferably sorbitol or concentrated glycerin.

[0049] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total mass of the oral composition, thereby providing an oral composition with excellent moisturizing power in the oral cavity. The content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total mass of the oral composition, thereby providing an oral composition that is easy to rinse with gargle.

[0050] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0051] The flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium, since it has a strong sweetness and can adjust the taste even with a small amount.

[0052] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0053] The flavoring agent may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0054] Examples of coloring agents include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and coumarind colorant; legal colorants such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; and one or more selected from the group consisting of riboflavin and titanium dioxide.

[0055] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffers.

[0056] The solvent may be water, or a lower alcohol such as ethanol, propanol, etc. The solvent may be a liquid base.

[0057] The content of water in the oral composition can be, for example, the remainder after excluding components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, of the entire oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or the oral composition contains ethanol but the ethanol content is 5% by mass or less, which can suppress strong irritation to the oral cavity.

[0058] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0059] Other bases include, for example, sodium bicarbonate.

[0060] Detergents include, for example, sodium polyphosphate.

[0061] The adsorbent may be, for example, β-cyclodextrin.

[0062] Furthermore, in addition to the above components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0063] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. The oral composition is preferably a dentifrice composition, more preferably a toothpaste composition, which can further improve the ease of handling of the oral composition. From the same viewpoint, the oral composition is preferably in the form of a paste or gel.

[0064] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. Examples of toothbrushes that can be used with the oral composition include known toothbrushes. The toothbrush used in conjunction with the oral composition may be a conventional commercially available toothbrush.

[0065] (Manufacturing method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other ingredients as appropriate. Here, in order to obtain an oral composition whose residual rate when hydrated falls within a specific range, it is important to appropriately select, for example, the components and blending ratios contained in the oral composition, as well as to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the formulation. Abrasive silica and inorganic binders are preferably used in combination, and abrasive silica and thickening silica are more preferably used in combination. It is also preferable to further incorporate an organic binder into the oral composition. It is also preferable to further incorporate a humectant into the oral composition. It is also preferable to carry out the manufacturing process of the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add the thickening silica, abrasive, and other components as appropriate during or after mixing the humectant, organic binder, and water, and then stir and mix until uniform. It is also preferable to premix a portion of the humectant and the organic binder, add the mixture when the mixture is uniform, and stir until uniform. It is even more preferable to carry out these steps under vacuum.

[0066] (Toothpaste) In this embodiment, the dentifrice is the oral composition filled in a tube container, and preferably a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between cushioning properties during tooth brushing and ease of spreading of the oral composition to the teeth and gums, and by filling this into a tube container to make a dentifrice, for example, uneven distribution of the oral composition can be prevented and the oral composition can be easily spread to desired areas. Furthermore, the squeezed dentifrice prevents excessive irritation during tooth brushing and provides a pleasant feel when used, such as a pleasant cushioning sensation in the oral cavity.

[0067] Oral compositions such as toothpaste compositions are preferably filled in tube containers. As the tube container, for example, known containers can be used. The material of the tube container can be one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc., and metal materials such as aluminum, etc. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum-laminated tube container may be used in which the innermost layer of the container is made of polyethylene and further includes an aluminum layer.

[0068] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more, which can more stably reduce the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and even more preferably 9 mm or less, which can efficiently prevent dripping. The length of the tube container excluding the discharge port may be about 50 to 160 mm, and the outer circumferential length in the width direction of the tube container may be about 20 to 120 mm.

[0069] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted. [Example]

[0070] The present embodiment will be specifically described below with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0071] (Examples 1 to 8, Comparative Examples 1 and 2) In this example, oral compositions, which are toothpaste compositions, were prepared and evaluated. The formulations, measurements, and evaluation results for each example are shown in Tables 1 and 2. The formulations of each component in these tables are in mass %, and the particle size of silica is the average particle size. Details of the components listed in Tables 1 and 2 are shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Concentrated glycerin for cosmetics: Concentrated glycerin, manufactured by Sakamoto Pharmaceutical Industry Co., Ltd. Sodium alginate SHG: Sodium alginate, manufactured by Kohara Co., Ltd. NIKKOL SLS: Sodium lauryl sulfate, manufactured by Nikko Chemicals Caustic soda (48%): sodium hydroxide solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0072] (Preparation of oral composition) Sorbitol or glycerin and purified water were weighed into a beaker, and the organic binder was gradually added while stirring at 2500 rpm at 80°C using an emulsifying and dispersing device (Labo-Lution, Primix) and a stirring unit (Homodisper 2.5, Primix). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring with a rubber spatula each time until the mixture was uniform.

[0073] (Measurement of residual rate when wet) Using the method 1 described above, the residual rate when wet was measured at 25°C according to the following procedure. (Method 1) 2.0 g of each toothpaste composition and 10 g of water were weighed into a 1.30 mL beaker. The weighed amount [g] of the oral composition was recorded. 2. A stirring bar was placed in the beaker and the mixture was stirred on a magnetic stirrer at 120 rpm for 20 seconds. 3. After stirring, the contents of the beaker were transferred onto a nylon mesh with a pore size of 100 μm and allowed to stand for 30 seconds. After standing, no filtrate dripped from the nylon mesh. 4. The amount of residue [g] on the nylon mesh was weighed, and the residual rate when wet was calculated based on the following formula (1). Residual rate when wet (%)=100*residue amount / weighed amount (1)

[0074] (Evaluation method) Each toothpaste composition was filled into a tube container, and the cushioning properties and ease of spreading onto the teeth and gums were evaluated. The tube container used was a laminated tube made of low-density polyethylene (LDPE) with a diameter of 19 mm and a size of 40Φ x 130H (40Φ One-Touch Tube-124.6, manufactured by Takemoto Container Co., Ltd.), and the cap used was a one-touch cap made of polypropylene with a diameter of 6 mm and a size of 39Φ x 24H (T-40Φ One-Touch CAP II, manufactured by Takemoto Container Co., Ltd.).

[0075] (Cushioning) Three evaluators applied a 1.5 cm length of each toothpaste composition to a toothbrush (manufactured by Lion Corporation) with an 18 mm head and saturated polyester resin bristles, and applied it to the entire teeth. During application, the softness of the toothbrush's contact with the gums and tooth surface was evaluated by consensus according to the following criteria, with A to C being considered acceptable. A: It feels soft to the touch. B: Feels slightly soft C: A slight change in the impact D: I don't feel any softness at all.

[0076] (Easy to reach teeth and gums) Three evaluators applied a 1.5 cm length of each toothpaste composition to the toothbrush, and the ease of spreading the composition over the teeth and gums was evaluated by consensus according to the following criteria, with A and B being considered acceptable. A: It spreads easily over the teeth and gums. B: I feel it spreading all over my teeth and gums. C: It tends to remain in a localized area in the mouth, making it difficult to spread to the entire teeth and gums. D: It tends to remain locally in the mouth and is almost impossible to spread over the entire teeth and gums.

[0077] [Table 1]

[0078] Table 2

Claims

1. An oral composition comprising an abrasive and a binder, An oral composition having a residual rate when wet of 60% or more and 180% or less, as measured by the following method 1. (Method 1) 1. Weigh 2.0 g of the oral composition and 10 g of water into a 30 mL beaker. Record the amount (g) of the oral composition weighed.

2. Place a stirring bar in the beaker and stir on a magnetic stirrer at 120 rpm for 20 seconds.

3. After stirring, the contents of the beaker are transferred onto a nylon mesh with a pore size of 100 μm and allowed to stand for 30 seconds.

4. The amount of residue [g] on the nylon mesh is weighed, and the residual rate when wet is calculated based on the following formula (1). Residual rate when containing water (%) = 100 * Residue amount / weighed amount (1)

2. The oral composition of claim 1 , wherein the binder comprises a thickening silica.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. 4. The oral composition according to claim 3, wherein the organic binder is one or more selected from the group consisting of carboxymethyl cellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).

5. The oral composition of claim 1 or 2, further comprising a humectant.

6. The oral composition of claim 1 or 2, wherein the abrasive comprises abrasive silica.

7. The oral composition according to claim 1 or 2, which is a dentifrice composition.

8. 3. The oral composition according to claim 1, which is a toothpaste composition.

9. A dentifrice comprising the oral composition according to claim 8 packed in a tube container.

Images