Information processing system, information processing method, and program

Abstract

To provide an information processing system, a method and a program for facilitating management of a radioactive solution in a medical institution.SOLUTION: In the information processing system 1, the information processing device 2 and the user terminal 3 that manage the generator, which is a device capable of extracting a radioactive solution used for preparation of a radiopharmaceutical by eluting (milking) a daughter nuclide from a parent nuclide in a radioactive equilibrium, acquire elution information on elution of a radioactive solution using at least one generator and administration information on an administration solution prepared using at least a part of the radioactive solution for administration to a subject while performing synchronization of information, among the generators, designation of a target generator in which elution is performed or has been performed in a mode in which a solution for administration can be prepared is received, and designated elution information and administration information are associated with each other and managed so as to indicate that the solution for administration is prepared using a radioactivity solution eluted from the designated target generator.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to an information processing system, an information processing method, and a program. [Background technology]

[0002] Patent Document 1 discloses a technology for improving the efficiency of radiopharmaceutical preparation work. The management device according to this technology includes a calculation unit, a determination unit, and a presentation unit. The calculation unit calculates the required amount of radioactivity based on patient information about the patient and test order information about the radiological test. The determination unit determines a preparation method for the radiopharmaceutical based on the calculated required amount of radioactivity and the radioactivity concentration of a radioactive solution that can be supplied within the hospital. The presentation unit presents the determined preparation method. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 2019-185116 Summary of the Invention [Problem to be solved by the invention]

[0004] However, although strict management is required for the handling of the radioactive solution eluted from the generator, there is still room for improvement in the technology for managing the complex process involved in the handling of the radioactive solution in medical institutions, such as the elution of the radioactive solution, the preparation of the administration solution using the radioactive solution, and the administration of the administration solution to the subject. [Means for solving the problem]

[0005] According to one aspect of the present invention, there is provided an information processing system for managing generators in a medical institution, the information processing system comprising at least one processor capable of executing a program to perform the following steps: in an acquisition step, elution information regarding the elution of a radioactive solution using at least one generator and administration information regarding an administration solution prepared using at least a portion of the radioactive solution to be administered to a subject are acquired; in a generator designation step, a designation of a target generator from among the generators from which elution is performed or from which elution has been performed in a manner capable of preparing an administration solution is accepted; and in a management step, the information processing system manages the designated elution information and administration information in association with each other so as to indicate that the administration solution has been prepared using the radioactive solution eluted from the designated target generator.

[0006] This configuration makes it easier to manage radioactive solutions in medical institutions. [Brief explanation of the drawings]

[0007] [Figure 1] 1 is a configuration diagram illustrating an information processing system 1. FIG. [Figure 2] FIG. 2 is a block diagram showing a hardware configuration of an information processing device 2. [Figure 3] FIG. 2 is a block diagram showing the hardware configuration of a user terminal 3. [Figure 4] 1 is an activity diagram showing an example of the flow of information processing executed in the information processing system 1. FIG. [Figure 5] FIG. 10 is a diagram illustrating an example of a front page. [Figure 6] FIG. 10 is a diagram showing an example of a screen displayed during processing related to a second operation. [Figure 7] FIG. 10 is a diagram showing an example of a screen displayed during processing related to a third operation. [Figure 8] FIG. 10 is a diagram showing an example of a screen displayed during processing related to a third operation. [Figure 9] FIG. 10 is a diagram illustrating an example of a configuration of a data structure constructed by information processing. DETAILED DESCRIPTION OF THE INVENTION

[0008] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the accompanying drawings. Various features shown in the following embodiments can be combined with each other.

[0009] 1. Hardware Configuration This section explains the hardware configuration.

[0010] <Information Processing System 1> FIG. 1 is a configuration diagram showing an information processing system 1. The information processing system 1 is used, for example, to manage generators in medical institutions. The generator is a device capable of extracting a radioactive solution used in preparing radiopharmaceuticals by eluting (milking) daughter nuclides from parent nuclides in radioactive equilibrium. At least a portion of the radioactive solution is separated as a radioactive solution and can be provided in combination with a predetermined drug. By mixing the radioactive solution with the drug, an administration solution is obtained that is administered to a recipient, such as a patient.

[0011] The information processing system 1 includes an information processing device 2 and a user terminal 3. The information processing device 2 and the user terminal 3 are configured to be able to communicate with each other via a telecommunications line. In one embodiment, the information processing system 1 is made up of one or more devices or components. For example, if the information processing system 1 is made up of only the information processing device 2, the information processing system 1 can be the information processing device 2. These components will be described below.

[0012] <Information processing device 2> 2 is a block diagram showing the hardware configuration of the information processing device 2. The information processing device 2 includes a communication unit 21, a storage unit 22, and a processor 23, and these components are electrically connected via a communication bus 20 inside the information processing device 2. Each component will be further described.

[0013] The communication unit 21 is preferably a wired communication means such as USB, IEEE1394, Thunderbolt (registered trademark), wired LAN network communication, etc., but may also include wireless LAN network communication, mobile communication such as 3G / LTE / 5G, BLUETOOTH (registered trademark) communication, etc. as needed. In other words, it is more preferable to implement it as a collection of multiple communication means. In other words, the information processing device 2 may communicate various information from the outside via the communication unit 21 and the network.

[0014] The memory unit 22 stores various pieces of information defined above. This can be implemented, for example, as a storage device such as a solid state drive (SSD) that stores various programs and the like related to the information processing device 2 executed by the processor 23, or as a memory such as a random access memory (RAM) that stores temporarily required information (arguments, arrays, etc.) related to the program operations. The memory unit 22 stores various programs, variables, etc. related to the information processing device 2 executed by the processor 23. In this embodiment, the memory unit 22 stores a management data structure for managing generators in medical institutions. The management data structure will be described in detail later.

[0015] The processor 23 processes and controls the overall operations related to the information processing device 2. The processor 23 is, for example, a central processing unit (CPU) not shown. The processor 23 realizes various functions related to the information processing device 2 by reading out predetermined programs stored in the storage unit 22. In other words, information processing by software stored in the storage unit 22 is specifically realized by the processor 23, which is an example of hardware, and can be executed as each functional unit included in the processor 23. These will be described in more detail in the next section. Note that the processor 23 is not limited to being single, and multiple processors 23 may be provided for each function. A combination of these may also be used.

[0016] Here, an example of the function of the processor 23 will be described. The processor 23 is configured to be able to acquire information from the user terminal 3 or other devices. The processor 23 is configured to be able to acquire various pieces of information by reading out various pieces of information stored in a storage area that is at least a part of the memory unit 22 and writing the read out information in a working area that is at least a part of the memory unit 22. The storage area is, for example, an area of ​​the memory unit 22 that is implemented as a storage device such as an SSD. The working area is, for example, an area that is implemented as a memory such as a RAM. Note that acquisition by the processor 23 includes acquiring output results of each functional unit included in the processor 23.

[0017] The processor 23 is configured to be able to display various types of information. The information can be presented to the user via the display unit 34 of the user terminal 3 or another device. In such a case, for example, the processor 23 controls the display unit 34 of the user terminal 3 to display visual information such as screens, images including still images or moving images, icons, messages, etc. The processor 23 may generate only rendering information for displaying the visual information on the user terminal 3. Note that the processor 23 may present the output information to the user without going through the user terminal 3 or another device user.

[0018] <User terminal 3> 3 is a block diagram showing the hardware configuration of the user terminal 3. The user of the user terminal 3 may be a medical professional at a medical institution, such as a person in charge of managing the inventory of the generator, a person in charge of elution who elutes the radioactive solution from the generator, a person in charge of preparation who generates a radioactive separation solution from the radioactive solution and combines the radioactive separation solution with a predetermined drug to prepare an administration solution, or a person in charge of administration who administers the administration solution to a subject such as a patient. The user terminal 3 includes a communication unit 31, a storage unit 32, a processor 33, a display unit 34, an input unit 35, and a reading unit 36, and these components are electrically connected via a communication bus 30 within the user terminal 3. The description of the communication unit 31, the storage unit 32, and the processor 33 is omitted here, as they are similar to the description of each unit in the information processing device 2.

[0019] The display unit 34 may be included in the housing of the user terminal 3 or may be externally attached. The display unit 34 displays a graphical user interface (GUI) screen that can be operated by the user. This is preferably implemented by selectively using display devices such as a CRT display, a liquid crystal display, an organic EL display, or a plasma display depending on the type of user terminal 3.

[0020] The input unit 35 is configured to be able to accept input from a user. The input unit 35 may be included in the housing of the user terminal 3 or may be externally attached. For example, the input unit 35 may be implemented as a touch panel integrated with the display unit 34. The touch panel allows the user to input tapping, swiping, and the like. Of course, instead of a touch panel, a switch button, a mouse, a QWERTY keyboard, a voice recognition device, a gesture detection device, a gaze detection device, a biosignal detection device, an imaging device, and the like may be used. That is, the input unit 35 accepts an operation input made by the user. In response, the input unit 35 transfers a signal corresponding to the operation input to the processor 33 via the communication bus 30. The processor 33 can execute predetermined control and calculations as necessary.

[0021] The reading unit 36 ​​is configured to read the target identification information. The reading unit 36 ​​may be included in the housing of the user terminal 3 or may be attached externally. The reading unit 36 ​​may include, for example, an imaging device such as a camera capable of reading two-dimensional barcodes, or an optical scanner capable of reading barcodes and the like.

[0022] 2. Examples of information processing In this section, the information processing executed in the information processing system 1 described above will be described.

[0023] The information processing device 2 and the user terminal 3 execute this information processing while synchronizing information. When communication with the information processing device 2 is impossible or difficult, the user terminal 3 executes a pre-installed application program to execute information input and registration processes in a temporary local environment, and when good communication with the information processing device 2 is established, the information stored in the storage unit 22 can be updated by transmitting information newly generated, registered, etc. in the user terminal 3. Furthermore, the information processing device 2 can be configured to update data stored in the processor 33 of the user terminal 3 when good communication with the user terminal 3 is established.

[0024] 2.1. Information processing flow FIG. 4 is an activity diagram showing an example of the flow of information processing executed in the information processing system 1. As shown in FIG. 4, first, in activity A1, the processor 33 of the user terminal 3 displays a front page on the display unit 34. FIG. 5 is a diagram showing an example of the front page. As shown in FIG. 5, the front page 4 may include an inventory area 41 that accepts a first operation for registering generator information, a preparation area 42 that accepts a second operation for registering information related to elution work, and an administration area 43 that accepts a third operation for registering information related to the administration of an administration solution to a subject. The front page 4 may also include a data confirmation area 44 for confirming and changing the contents of the management data structure.

[0025] First, the flow of processing when the first operation is performed will be described. As shown in Fig. 4, in this case, processing proceeds from activity A1 to activity A101, and processor 23 accepts input of generator information through processor 33. Generator information is information about generators managed in medical institutions. For example, processor 33 displays an input screen for generator information on display unit 34 in response to the first operation, and transmits the input content to information processing device 2. Processor 23 accepts the input content transmitted from processor 33 as generator information. The generator information may include, for example, the generator ID, product name, testing date and time, and testing amount (amount of radioactivity at the testing date and time), etc.

[0026] Next, in activity A102, the processor 23 registers the received generator information. As a result, the processor 23 updates the management data structure based on the received generator information. At this time, the processor 23 may issue an identification code (for example, a two-dimensional barcode unique to the generator) to be assigned to the generator registered via the user terminal 3. The identification code is configured to be readable by the reading unit 36. The identification code can be assigned to the generator by the person in charge of registering the generator. Thereafter, this information processing related to the registration of the generator information is terminated.

[0027] Next, the processing flow when the second operation is performed will be described. When the second operation is performed, processor 23 registers elution information in response to a user's operation and manages the elution information in a management data structure in association with the registered generator information. The elution information is information about the elution of a radioactive solution using at least one generator. For example, the elution information may include the amount of radioactivity of the radioactive solution eluted from the generator, information about the person in charge of elution at the medical institution who can perform elution using the generator, and information about the elution time, which is the time when the elution was performed. Note that after a single elution, the concentration of radionuclides in the generator becomes saturated, and it takes a certain period of time for a radioactive solution of an appropriate concentration to be obtained by performing elution again. Among generators, a generator that performs elution in a manner that allows the preparation of an administration solution or that has already been eluted may be referred to as a target generator. The target generator is not limited to a generator that has already performed elution to prepare an administration solution (e.g., a generator that performed elution before the present time and whose radioactivity level at that time is equal to or exceeds a predetermined value), but may also include a generator that is about to perform elution in a manner that allows the preparation of an administration solution (e.g., a generator whose radioactivity level at the scheduled time of elution is equal to or exceeds a predetermined value).

[0028] As an example, first, in activity A201, the processor 23 acquires person-in-charge information regarding the person in charge of elution based on a user's operation on the input unit 35. The person-in-charge information is, for example, information indicating a medical professional or the like registered at a medical institution who is authorized to handle radioactive materials (for example, a registered person with a radioactive material handling supervisor license). The person-in-charge information may be displayed, for example, on the display unit 34 in a manner that allows the user to view it at a glance. The processor 23 accepts, based on the acquired person-in-charge information through a user's input to the input unit 35, the designation of the person in charge of elution who performed the elution on the target generator.

[0029] Next, in activity A202, processor 23 accepts the designation of a generator based on a user's operation on input unit 35. For example, processor 33 generates the designation of the generator by reading, via input unit 35, an identification code assigned to the generator that will perform (or has performed) the elution, and transmits the designation to processor 23. Processor 23 accepts the designation of the generator transmitted from processor 33.

[0030] Next, in activity A203, processor 33 generates the results of the latest elution work based on the operation on input unit 35 and transmits them to processor 23. Processor 23 accepts the results of the latest elution work transmitted from processor 33. The results of the elution work may include at least a portion of the elution information, such as the date and time when the elution work was performed, the calculated value of the radioactivity of the radioactive solution, and the actually measured value of the radioactivity of the radioactive solution.

[0031] Next, in activity A204, the processor 23 generates elution information regarding the radioactive solution eluted from the generator based on the received information. At this time, the processor 23 may issue an identification code (e.g., a two-dimensional barcode) associated with the elution information via the user terminal 3 or the like. The issued identification code is, for example, assigned by the elution person to a container (e.g., a vial) containing the radioactive solution.

[0032] Next, in activity A205, processor 23 associates the elution information generated in activity A204 with the generator information specified in activity A202 and registers the information in the management data structure. By this association, processor 23 can manage that the radioactive solution corresponding to the elution information was obtained by elution using the specified generator.

[0033] Thereafter, when the radioactive solution is separated into containers such as vials, in activity A206, processor 33 accepts input of separation information regarding the radioactive solution separated into containers such as vials from the radioactive solution. The separation information may include, for example, the date and time when the radioactive solution was separated from the radioactive solution, the amount of radioactivity in the radioactive solution, etc. Processor 33 transmits the input separation information to information processing device 2, and processor 23 acquires the transmitted separation information. Note that, when the radioactive solution has been prepared as a kit formulation using a drug such as an additive, the separation information may include information regarding a drug to be mixed with the radioactive solution. The information may include, for example, the type and amount of the drug to be mixed.

[0034] Next, in activity A207, the processor 23 associates the obtained separation information with the specified generator information and records it in the management data structure, thereby enabling the processor 23 to manage the information assuming that the radioactive separation corresponding to the separation information originates from the radioactive solution eluted from the target generator corresponding to the specified generator information.

[0035] Thereafter, the processor 23 ends this information processing related to the generation and management of elution information and the like.

[0036] Here, an example of a screen displayed on the display unit 34 during processing related to the second operation will be described. FIG. 6 is a diagram showing an example of a screen displayed during processing related to the second operation. As shown in FIG. 6, when the preparation area 42 on the front page 4 is operated, the processor 33 first displays screen 5 on the display unit 34. Screen 5 is configured to allow the user to specify an elution person from among candidates for elution persons. For example, screen 5 includes a person-in-charge candidate area 51 and a transition button 52, which present the candidates for elution persons in a list format. "Preparer 1," "Preparer 2," and "Preparer 3" in the person-in-charge candidate area 51 are each registered persons authorized to use a generator at a medical institution to administer radioactive solution. The user can specify a person to operate the generator from among the candidates. By operating the transition button 52 on screen 5, the processor 33 transitions the display content of the display unit 34 from screen 5 to screen 6.

[0037] Screen 6 is a screen for accepting generator information. Screen 6 includes a scan button 61 and a transition button 62. When the scan button 61 is operated, the processor 33 activates the reading unit 36 ​​and reads the identification code assigned to the generator. If the identification code is successfully read, the processor 33 reads the generator information corresponding to the identification code from the management data structure and displays it in a display area 63 located in the center of screen 6. In this embodiment, the display area 63 displays the generator information, including the generator's product name ("Ultra Technecow (registered trademark)"), the calibration date, the calibration time, the calibration amount, and the radionuclide ("Tc-99m 239A-5214B"). When the user confirms that there are no problems with the content displayed in the display area 63, the transition button 62 is operated. In response to this, the processor 33 transitions the display content of the display unit 34 from screen 6 to screen 7.

[0038] The screen 7 is a screen for inputting elution information. The screen 7 includes a past area 71, an input area 72, and a registration button 73.

[0039] The past area 71 is an area where elution information relating to elutions that have been performed in the past (for example, the previous) using the same generator is displayed. For example, the past area 71 may display the elution date and time and the amount of radioactivity when the previous elution was performed.

[0040] The input area 72 is an area configured to allow input of elution information regarding the most recent elution performed using the target generator. The input area 72 is configured to allow input of, for example, the date and time when the elution was performed, the theoretical value (calculated value) of the amount of radioactivity of the radioactive solution at that date and time, and the actually measured value of the amount of radioactivity of the radioactive solution. The theoretical value of the amount of radioactivity can be calculated based on information such as the half-life specific to the radionuclide, the period from the previous elution to the current elution, and the amount of radioactivity of the radioactive solution in the previous elution.

[0041] The registration button 73 is a UI for executing registration of the elution information input in the input area 72. When the registration button 73 is operated, the information input in the input area 72 is generated as elution information. Thereafter, when the information processing device 2 and the user terminal 3 become able to communicate with each other, the management data structure stored in the information processing device 2 is updated.

[0042] Next, returning to FIG. 4, the flow of processing when the third operation is performed will be described. The processing related to the third operation is performed when preparing an administration solution using a radioactive solution corresponding to the elution information generated in the second operation and administering the administration solution to a recipient. When the third operation is performed, the processor 23 generates administration information in response to a user's operation, associates the administration information with generator information related to the target generator among the registered generators, and manages the administration information in a management data structure. This allows for centralized management of the amount of radioactivity from the radioactive solution eluted from the generator until it is administered to a recipient.

[0043] The administration information is information about an administration solution prepared using at least a portion of the radioactive solution to be administered to a subject. For example, the administration information may include preparation information about the preparation of the administration solution, the radioactivity amount of the administration solution, the filled radioactivity amount, the remaining radioactivity amount, etc. The filled radioactivity amount is the radioactivity amount of the administration solution filled in an administration device (e.g., a syringe) for administering the administration solution to a subject. The remaining radioactivity amount is the radioactivity amount of the administration solution remaining in the administration device after administration to the subject. The administration information may also include any information about the administration subject, the time of administration, etc. The above-mentioned liquid separation information may also be managed as part of the preparation information.

[0044] A specific example of processing related to the third operation will be described below. First, in activity A301, the processor 33 receives information about the administration recipient. The administration recipient is a person who undergoes a test using an administration solution at a medical institution, such as a patient. As an example, the reading unit 36 ​​first reads an identification code previously assigned to the administration recipient (for example, a tag with a barcode distributed to the administration recipient), and the processor 33 acquires information about the administration recipient based on the reading result.

[0045] Next, in activity A302, the processor 33 receives a designation of a radioactive separation solution. For example, the processor 33 determines that the reading unit 36 ​​reads an identification code attached to the radioactive separation solution and that the radioactive separation solution corresponding to the identification code has been designated.

[0046] Next, in activity A303, the processor 23 accepts designation of a target generator from among the registered generators (for example, through the user terminal 3). For example, the user terminal 3 displays on the display unit 34 a list of generators that can be designated as target generators, and the user designates one of the generators in the list as the target generator, thereby allowing the processor 23 to accept the designation.

[0047] Next, in activity A304, the processor 33 displays generator information about the specified target generator and information about the specified drug on the display unit 34. This makes it possible to prompt the user to check whether there are any errors in the target generator and drug designation.

[0048] Next, in activity A305, the processor 23 accepts a designation for a drug (for example, through the user terminal 3). For example, the user terminal 3 displays a list of designatable candidates on the display unit 34, and the user designates one of the drugs in the list, whereby the processor 23 can accept the designation.

[0049] Next, in activity A306, processor 23 accepts (through user terminal 3) the designation of a preparer. The preparer is the person in charge of preparing the administration solution using the radioactive separation solution and sealing it in an administration device such as a syringe. The preparer then prepares the administration solution. Information about the preparer is an example of preparation information. At this time, processor 33 may also accept, as preparation information, information about a drug to be mixed with the radioactive separation solution when preparing the administration solution.

[0050] Next, in activity A307, processor 23 receives (e.g., from the user, via user terminal 3) administration information after preparation (e.g., immediately after preparation) and information regarding the radioactivity of the administration solution in the syringe immediately after the administration solution is dispensed into the syringe. The administration information after preparation includes, for example, the time when the administration solution was prepared and the radioactivity of the administration solution in the vial after preparation. Furthermore, the information regarding the administration solution in the syringe may include, for example, the time when the administration solution was prepared and the radioactivity of the administration solution in the syringe. Each radioactivity amount may be a value that has been decay-corrected based on the time when the administration solution was prepared.

[0051] Next, in activity A308, processor 33 receives administration information regarding the administration solution in the administration stage. The administration information regarding the administration solution in the administration stage may include, for example, the amount of radioactivity of the administration solution measured immediately before the administration of the administration solution and the time at which the measurement was made (in other words, the time at which the administration solution is administered).

[0052] Next, in activity A309, the processor 33 receives designation of an administering person. The designated administering person is a person who administers the administration solution to the administration subject. The designated administering person can be managed as part of the administration information.

[0053] Next, in activity A310, the processor 33 receives approval of the received information (for example, preparation information or administration information) from the user. The approved information is transmitted to the information processing device 2.

[0054] Thereafter, in activity A311, the processor 23 associates and manages the various pieces of information transmitted from the processor 33. A specific manner of association will be described in detail in the next section.

[0055] Here, an example of a screen displayed on the display unit 34 during processing related to the third operation will be described. FIGS. 7 and 8 are diagrams showing example screens displayed during processing related to the third operation. As shown in FIG. 7, when the administration area 43 is operated on the front page 4, screen 8 is displayed. Screen 8 is a screen on which the use of the radioactive solution (and further the radioactive separation solution) can be specified. Screen 8 may include an RI administration button 81 for specifying the preparation and administration of a solution for administration as the use of the radioactive solution, and an outside administration button 82 for specifying other uses. When the RI administration button 81 is operated, the processor 33 transitions the display content of the display unit 34 to screen 9.

[0056] Screen 9 is a screen for accepting information about a patient, who is an example of a recipient. Screen 9 may include a scan button 91 and a transition button 92. When the scan button 91 is operated, processor 33 activates reading unit 36 ​​and causes it to scan an identification code (e.g., a barcode) assigned to the patient. If the scan is successful, the recipient corresponding to the identification code is designated, and information about the recipient, such as the patient's name, date of birth, age, sex, height, weight, and test items, which is used to prevent patient mix-ups, is displayed in a central area 93 of screen 9. When the transition button 92 is operated, processor 33 transitions the display content of display unit 34 to screen 10.

[0057] Screen 10 is a screen for specifying a target generator (elution information) corresponding to a radioactive separation solution used in preparing a solution for administration. Screen 10 may include a list display button 101 and a transition button 102. When list display button 101 is operated, processor 33 displays screen 11.

[0058] Screen 11 is a screen for specifying a target generator. Screen 11 includes a list 111 displaying candidate generators that can be specified as the target generator, and a transition button 112. The generators displayed in list 111 may be generators that have undergone or are likely to undergo elution within a certain period of time, based on the time of elution. When the user operates transition button 112 after specifying one of the generators displayed in list 111 as the target generator, screen 12 is displayed. Screen 12 is a screen for confirming generator information related to the target generator associated with the administration solution. In this embodiment, screen 12 can also function as a screen for confirming drug information related to the drug used in the preparation. For example, screen 12 includes area 121, a drug selection button 122, and a transition button 123. Area 121 in screen 12 displays elution information related to the radioactive solution eluted from the target generator and drug information related to the drug used in the preparation. The elution information related to the radioactive solution eluted from the target generator may include the assay date, assay time, and assay amount. The drug information is displayed in area 121 by being selected from a drug candidate list (not shown) that is displayed when drug selection button 122 is operated. The drug candidate list is configured to be able to list, for example, drug candidates that can be combined with the radioactive solution, along with at least some of the drug information related to the drug. The drug information related to the drug to be prepared may include the type of drug, the amount of drug, etc. When transition button 123 is operated, screen 13 is displayed.

[0059] Screen 13 is a screen for designating a preparer who will prepare the administration solution using the radioactive separation solution. Screen 13 includes a list 131 showing candidate preparers and a transition button 132. When the transition button 132 is operated after the preparer is designated in list 131, screen 14 is displayed.

[0060] Screen 14 is a screen for accepting post-preparation administration information. Screen 14 includes an area 141 for inputting post-preparation separation information, an area 142 for inputting administration information related to the prepared administration solution, a temporary save button 143, and a transition button 144. Area 141 displays the radioactivity amount of the radioactive separation solution remaining in the vial after preparation as separation information, and the time corresponding to that radioactivity amount. Area 142 can be used to input the radioactivity amount of the administration solution dispensed with a syringe after preparation and the measurement time. The temporary save button 143 is a button for temporarily storing previously input information, such as information about the administration recipient, separation information, generator information related to the target generator, and preparation personnel information, in memory unit 32. This allows information related to the series of operations from radioactive separation to obtaining the administration solution to be recorded. When transition button 144 is operated, the acceptance of the radioactivity amount information up to the preparation of the administration solution, among the administration information, is terminated, and screen 15 is displayed.

[0061] 8, screen 15 is a screen for receiving input of administration information regarding the administration solution at the administration stage. Screen 15 includes an area 151 in which the amount of radioactivity of the administration solution at the time of administration (immediately before administration) and the time the administration solution was administered can be input, an area 152 in which the amount of administration solution remaining in the syringe after administration (amount of remaining radioactivity) can be input, a temporary save button 153 for temporarily saving the input contents up to that point, and a transition button 154. When the transition button 154 is operated with the user having input information at least in area 151, screen 16 is displayed.

[0062] Screen 16 is a screen for inputting the administration person. Screen 16 includes a list 161 of candidate administration persons that can be designated, a scan button 162 for reading the identification code of the administration person, and a transition button 163. When scan button 162 is operated, processor 33 activates reading unit 36, reads the identification code (barcode, etc.) assigned to the administration person, and designates the administration person based on the results. When transition button 163 is operated with the administration person designated, screen 17 is displayed.

[0063] Screen 17 is a screen for confirming the final state of the administration solution and registering the result in the management data structure. Screen 17 includes an area 171 for displaying the administration result, an operation unit 172 for specifying how to handle the remaining radioactive solution, and a registration button 173. Area 171 displays the administration result, including the administration date and time, the amount of radioactivity administered, and the amount of radioactivity of the administration solution remaining in the vial and the syringe after preparation. The amount of radioactivity administered can be calculated by subtracting the amount of radioactivity remaining in the administration solution after administration from the amount of radioactivity in the administration solution at the time of administration. Operation unit 172 is configured to specify whether the remaining radioactive solution should be treated as waste solution. When operation unit 172 is operated to indicate that the remaining radioactive solution should be discarded ("Discard this vial" is checked), processor 33 generates waste solution information for the waste solution, associates it with the designated separation information, and sets the separation information as undesignable for future information processing. This makes it possible to easily manage in the management data structure that the waste solution originates from the radioactive separation corresponding to the specified separation information. When the registration button 173 is operated, the processor 33 confirms the information that has been input so far and transmits the information to the information processing device 2 while communication with the information processing device 2 is established. The processor 23 updates the management data structure based on the transmitted information.

[0064] 2.2. Management Data Structure Next, an example of a management data structure DS constructed by the above-mentioned information processing will be described. Fig. 9 is a diagram showing an example of the configuration of a data structure constructed by the information processing. As shown in Fig. 9, the management data structure DS includes generator information D1, dissolution information D2, administration information D3, and disposal information D4. The contents of this information are as described above, so description thereof will be omitted.

[0065] The generator information D1 is associated with the elution information D2, which indicates from which generator the radioactive solution was eluted. The fact that multiple pieces of elution information D2 are associated with the same generator information D1 indicates that multiple elutions have been performed using the same generator. The past elution history can be obtained based on the elution information D2 associated in this way via the generator information D1.

[0066] The elution information D2 is associated with the administration information D3 (particularly, the separation information). The processor 23 then manages the specified elution information and administration information in association with each other, so as to indicate that the administration solution was prepared using a radioactive solution eluted from a specified target generator. This configuration allows the radioactive solution to be administered to a subject to be easily associated with the radioactive solution eluted from the generator from which the radioactive solution was derived, thereby facilitating the management of the radioactive solution at medical institutions. The processor 23 can then manage the elution information and preparation information (more specifically, the separation information) related to the specified target generator in association with each other, so as to indicate that the administration solution was prepared using a radioactive separation separated from the radioactive solution eluted from the specified target generator. This configuration allows for the centralized management of the usage history of the radioactive solution from the generator to the subject, including the radioactive solution eluted from the generator, the radioactive separation separated from the radioactive solution, and the administration solution prepared using the radioactive separation. The processor 23 can also manage information related to drugs in association with the elution information related to the specified target generator. This configuration allows for centralized management of the actual state of the administration solution administered to the patient in association with the generator. Furthermore, the processor 23 can manage administration information in association with elution information, including the designated elution personnel. This configuration improves the manageability of past generator operation history.

[0067] When multiple lower-level information (e.g., two sets of administration information D3 for the elution information D2) are associated with one higher-level information (e.g., elution information D2), the processor 23 can manage this information so as to indicate that multiple substances (e.g., radioactive separations, administration solutions, etc.) are produced from the same substance (e.g., radioactive solution) managed by the higher-level information. This configuration makes it easier to manage the balance of radioactivity. In FIG. 9, two sets of administration information A1 and A2 are associated with one elution information A, thereby managing the information so as to indicate that the two administration solutions are derived from the same radioactive solution.

[0068] Furthermore, the remaining amount of radioactivity distributed to each radioactive aliquot may be associated with the disposal information D4. This allows the processor 23 to manage information to indicate that the remaining amount of radioactive solution not used to separate the radioactive aliquots has been disposed of. The elution information D2 may include usage conditions indicating that the radioactive solution can be used to prepare an administration solution (e.g., a period during which the radioactivity of the radioactive solution is sufficient for use in preparing a radiopharmaceutical). When the usage conditions are no longer met, the processor 23 may manage the radioactive solution used for purposes other than the administration solution as discarded radioactive solution. This configuration eliminates the need to manage the remaining radioactive solution.

[0069] Each piece of administration information D3 is associated with one piece of elution information D2. This allows for centralized management of the amount of radioactivity throughout the entire process, from the elution of the radioactive solution by the generator to the production of the administration solution. The processor 23 may also manage the amount of waste radioactive solution derived from the administration solution in association with the elution information based on the amount of filled radioactivity and the amount of remaining radioactivity. This configuration allows the amount of radioactivity in the discarded administration solution to be associated with the original generator, facilitating centralized management of the generator and the waste solution. Here, the amount of remaining radioactivity in the administration information D3 is associated with the disposal information D4.

[0070] The processor 23 may also manage residual information about radioactive solution eluted from the generator that has been used for purposes other than the administration solution, based on the radioactivity of the radioactive solution and the radioactivity of the administration solution. This configuration can eliminate the need to manage the residual radioactive solution. Here, disposal information D4 is managed as an example of residual information, but information about radioactive solution used for adjusting RI equipment may also be managed as residual information.

[0071] <Other> The above embodiment may be modified as follows.

[0072] The elution process may be performed before the second operation or during the activities following the second operation. The order of the processes included in the activities may be changed as appropriate within the scope of technical compatibility. For example, the order of activity A202 and activity A203, or the order of activity A302 and activity A304 may be reversed.

[0073] The above information processing may be performed after each worker has performed their work, such as dissolving the radioactive solution, separating the radioactive solution, preparing the administration solution, and administering the administration solution, or may be performed in accordance with the progress of the work by each worker operating the user terminal 3 as appropriate while performing the work.

[0074] The administration information may be any information capable of managing radioactivity at least in part from the radioactive solution to the preparation of an administration solution. For example, the administration information may include only separation information related to the radioactive separation. Alternatively, the administration information may include information related to a solution at any stage obtained from the radioactive solution, such as a radioactive separation or an administration solution.

[0075] The information processing device 2 may be an on-premise type or a cloud type. As the information processing device 2 in the cloud type, the above-mentioned functions and processes may be provided in the form of, for example, SaaS (Software as a Service) or cloud computing.

[0076] In the above embodiment, the information processing device 2 performs various storage and control operations, but multiple external devices may be used instead of the information processing device 2. That is, various information and programs may be distributed and stored in multiple external devices using block chain technology or the like.

[0077] The above embodiment is not limited to the information processing system 1, and may be an information processing method or an information processing program. The information processing method includes each step of the information processing system 1. The program causes at least one computer to execute each step of the information processing system 1.

[0078] The information processing system 1 and the like may be provided in the following aspects.

[0079] (1) An information processing system for managing generators in a medical institution, comprising at least one processor capable of executing a program to perform the following steps: in an acquisition step, elution information regarding the elution of a radioactive solution using at least one generator and administration information regarding an administration solution prepared using at least a portion of the radioactive solution to be administered to a subject; in a generator designation step, a designation of a target generator among the generators from which the elution is performed or from which the elution has been performed in a manner capable of preparing the administration solution; and in a management step, an information processing system for managing the designated elution information and the administration information in association with each other so as to indicate that the administration solution was prepared using the radioactive solution eluted from the designated target generator.

[0080] (2) In the information processing system described in (1) above, the administration information includes preparation information regarding the preparation of the administration solution, and the preparation information includes separation information regarding the radioactive separation separated from the radioactive solution, and in the management step, the information processing system manages the elution information regarding the designated target generator and the preparation information in association with each other so as to indicate that the administration solution was prepared using the radioactive separation separated from the radioactive solution eluted from the designated target generator.

[0081] (3) In the information processing system described in (2) above, the preparation information further includes information regarding a drug to be mixed with the radioactive separation solution, and in the management step, the information regarding the drug is further managed in association with elution information regarding the specified target generator.

[0082] (4) In the information processing system described in any one of (1) to (3) above, the elution information includes the amount of radioactivity of the radioactive solution eluted from the generator, the administration information includes the amount of radioactivity of the administration solution, and in the management step, residual information on the radioactive solution eluted from the generator and used for purposes other than the administration solution is managed based on the amount of radioactivity of the radioactive solution and the amount of radioactivity of the administration solution.

[0083] (5) In the information processing system described in (4) above, the elution information includes a use condition indicating that the administration solution can be prepared using the radioactive solution, and in the management step, when the use condition is no longer satisfied, the radioactive solution used for a purpose other than the administration solution is managed as a discarded radioactive solution.

[0084] (6) In the information processing system described in any one of (1) to (5) above, the administration information includes a filled radioactivity amount, which is the amount of radioactivity of the administration solution filled in an administration device for administering the administration solution to the subject, and a residual radioactivity amount, which is the amount of radioactivity of the administration solution remaining in the administration device after administration to the subject, and in the management step, the information processing system manages the amount of waste of radioactive solution derived from the administration solution based on the filled radioactivity amount and the residual radioactivity amount in association with the elution information.

[0085] (7) In the information processing system described in any one of (1) to (6) above, the information processing system further includes a person-in-charge acquisition step for acquiring person-in-charge information regarding a person in charge of elution who can perform the elution using the generator at the medical institution, a person-in-charge designation step for accepting designation of the person in charge of elution who performed the elution for the target generator based on the acquired person-in-charge information, and a management step for managing the elution information including the designated person in charge of elution in association with the administration information.

[0086] (8) An information processing method, comprising the steps of the information processing system according to any one of (1) to (7) above.

[0087] (9) A program that causes at least one computer to execute each step of the information processing system according to any one of (1) to (7) above. Of course, this is not the case.

[0088] Finally, while various embodiments of the present disclosure have been described, they are presented as examples and are not intended to limit the scope of the invention. The novel embodiments may be embodied in various other forms, and various omissions, substitutions, and modifications may be made without departing from the spirit of the invention. Such embodiments and modifications are intended to be included within the scope and spirit of the invention, as well as within the scope of the inventions and their equivalents as defined in the claims. [Explanation of symbols]

[0089] 1: Information processing system 2: Information processing equipment 20: Communication bus 21: Communications Department 22: Storage section 23: Processor 3: User terminal 30: Communication bus 31: Communications Department 32: Storage section 33: Processor 34:Display section 35: Input section 36: Reading unit 4: Front page 41: Receiving area 42: Preparation area 43: Administration area 44: Data confirmation area 5: Screen 51: Candidate area for personnel 52: Transition button 6: Screen 61: Scan button 62: Transition button 63:Display area 7: Screen 71: Past area 72: Input area 73:Register button 8: Screen 81: Administration button 82: Out of dose button 9: Screen 91: Scan button 92: Transition button 93 :Area 10: Screen 101: List display button 102: Transition button 11: Screen 111: List 112: Transition button 12: Screen 121 :Area 122: Drug selection button 123: Transition button 13: Screen 131: List 132: Transition button 14: Screen 141 :Area 142 :Area 143: Temporary save button 144: Transition button 15: Screen 151 :Area 152 :Area 153: Temporary save button 154: Transition button 16: Screen 161: List 162: Scan button 163: Transition button 17: Screen 171 :Area 172:Operation unit 173:Register button D1: Generator information D2: Elution information D3: Administration information D4: Disposal Information DS: Data Structure

Claims

1. An information processing system for managing generators in a medical institution, at least one processor capable of executing a program to perform the following steps; In the obtaining step, elution information regarding elution of the radioactive solution using at least one generator and administration information regarding an administration solution prepared using at least a portion of the radioactive solution for administration to a subject are obtained; In the generator designation step, designation of a target generator from among the generators on which the elution is performed or on which the elution has been performed in a manner capable of preparing the administration solution is accepted; In the management step, an information processing system associates and manages the specified elution information with the administration information so as to indicate that the administration solution was prepared using a radioactive solution eluted from the specified target generator.

2. 2. The information processing system according to claim 1, the administration information includes preparation information regarding preparation of the administration solution; the preparation information includes separation information regarding a radioactive solution separated from the radioactive solution; In the management step, an information processing system manages the preparation information in association with elution information regarding the designated target generator so as to indicate that the administration solution was prepared using the radioactive solution separated from the radioactive solution eluted from the designated target generator.

3. 3. The information processing system according to claim 2, The preparation information further includes information about a drug to be mixed with the radioactive solution, In the management step, the information processing system further manages information about the drug in association with elution information about the designated target generator.

4. 2. The information processing system according to claim 1, the elution information includes the amount of radioactivity in the radioactive solution eluted from the generator; the administration information includes the radioactivity amount of the administration solution; In the management step, an information processing system manages residual information on radioactive solution eluted from the generator and used for purposes other than the administration solution, based on the radioactivity amount of the radioactive solution and the administration solution.

5. 5. The information processing system according to claim 4, the elution information includes a condition of use indicating that the administration solution can be prepared using the radioactive solution; In the management step, when the conditions for use are no longer satisfied, the radioactive solution used for purposes other than the administration solution is managed as a discarded radioactive solution.

6. 2. The information processing system according to claim 1, the administration information includes a filled radioactivity amount, which is the amount of radioactivity of the administration solution filled in an administration device for administering the administration solution to the subject, and a remaining radioactivity amount, which is the amount of radioactivity of the administration solution remaining in the administration device after administration to the subject; In the management step, the information processing system manages the amount of radioactive solution to be discarded derived from the administration solution based on the amount of filled radioactivity and the amount of remaining radioactivity in association with the elution information.

7. 2. The information processing system according to claim 1, Furthermore, in the person-in-charge acquisition step, person-in-charge information regarding a person in charge of elution who is capable of performing the elution using the generator at the medical institution is acquired, In the person-in-charge designation step, a designation of the elution person who performed the elution for the target generator is accepted based on the acquired person-in-charge information; In the management step, the information processing system manages the elution information including the designated person in charge of elution in association with the administration information.

8. An information processing method, comprising: A method comprising the steps of the information processing system according to any one of claims 1 to 7.

9. A program, A program that causes at least one computer to execute each step of the information processing system according to any one of claims 1 to 7.

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