Scalp components

Abstract

The present invention aims to provide a scalp composition, such as a hair growth agent or hair restoration agent, comprising at least glycyrrhetinic acid or a salt thereof, polyoxyethylene hydrogenated castor oil, and ethanol, wherein the composition does not cause the precipitation of precipitates over time. [Solution] A scalp composition that does not produce precipitates and / or insoluble matter can be provided by comprising (A) glycyrrhetinic acid or a salt thereof, (B) polyoxyethylene hydrogenated castor oil, (C) ethanol, and (D) one or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate.

Description

Technical Field

[0001] The present invention relates to a composition for the scalp.

Background Art

[0002] Conventionally, scalp compositions such as hair growth agents or hair growth stimulants containing glycyrrhetinic acid have been known. However, since glycyrrhetinic acid is oil-soluble and is a poorly soluble compound in preparations containing water, there is a problem that precipitates are likely to occur. In order to prepare a preparation in a state where glycyrrhetinic acid is dissolved, it has been reported to use a fermented product containing glycyrrhetinic acid hydroxide as a substitute for glycyrrhetinic acid or to reduce the addition amount of ethanol as a solvent (Patent Document 1). In addition, it has been reported that a preparation containing glycyrrhetinic acid, menthol or camphor, and two specific types of surfactants has excellent low-temperature stability (Patent Document 2). When the inventors of the present invention tried to develop a scalp composition such as a hair growth agent or a hair growth stimulant further containing polyoxyethylene hydrogenated castor oil as a solubilizing agent in glycyrrhetinic acid, it was found that a scalp composition containing ethanol, glycyrrhetinic acid or its salt, and polyoxyethylene hydrogenated castor oil has a problem that precipitates are likely to occur over time, especially under low-temperature storage.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0004] The object of the present invention is to provide a scalp composition, such as a hair growth agent or hair restoration agent, that contains at least ethanol, glycyrrhetinic acid or a salt thereof, and polyoxyethylene hydrogenated castor oil, which is less likely to produce precipitates over time even when stored at a low temperature of about 5°C. Furthermore, an object of the present invention is to provide a method for suppressing the precipitation that occurs over time when storing scalp compositions such as hair growth agents or hair restoration agents containing at least ethanol, glycyrrhetinic acid or a salt thereof, and polyoxyethylene hydrogenated castor oil at a low temperature of about 5°C. [Means for solving the problem]

[0005] In response to the above-mentioned problems, the present inventors found that adding one or more substances selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate to a scalp composition containing at least ethanol, glycyrrhetinic acid or a salt thereof, and polyoxyethylene hydrogenated castor oil significantly suppresses the precipitation of precipitates that occur over time when stored at low temperatures, thus completing the present invention. In other words, the present invention provides the following embodiments. [1] (A) Glycyrrhetinic acid or a salt thereof, (B) Polyoxyethylene hydrogenated castor oil, (C) Ethanol, and (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, A scalp composition containing the following: [2] A scalp composition according to [1], which is a hair growth agent or hair restoration agent composition. [3] The scalp composition according to [1] or [2] above, wherein the content of (D)1,3-butylene glycol is 1.8% by mass or more, and / or the content of polyethylene glycol monooleate is 0.2% by mass or more, based on the total mass of the scalp composition. [4] The scalp composition according to any one of [1] to [3] above, wherein the content of (B) polyoxyethylene hydrogenated castor oil relative to the total mass of the scalp composition is 0.3% by mass or more. [5] The scalp composition according to any one of [1] to [4] above, wherein the content of (A) glycyrrhetinic acid or a salt thereof, relative to the total mass of the scalp composition, is greater than 0.01% by mass and less than or equal to 0.55% by mass when converted to glycyrrhetinic acid. [6] The scalp composition according to any one of [1] to [5] above, wherein the content of (C) ethanol relative to the total mass of the scalp composition is less than 45% by mass. [7] A scalp composition according to any one of [1] to [6] above, comprising, in addition to components (A) to (D), at least one selected from the group consisting of carpronium chloride or its hydrate, hinokitiol, salicylic acid or its salt, pantothenyl ethyl ether, pyridoxine or its salt or its hydrate, diphenhydramine or its salt or its hydrate, and tocopherol acetate. [8] (A) Glycyrrhetinic acid or a salt thereof, (B) Polyoxyethylene hydrogenated castor oil, and (C) Ethanol, A method for preventing the precipitation of precipitates and / or insoluble matter in a scalp composition containing, (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, The method comprising adding to the composition. [9] A method for producing a scalp composition according to any one of [1] to [7] above, comprising mixing (A), (B), (C) and (D).

[10] The method according to [8] or [9], wherein the scalp composition is a hair growth agent or hair restoration agent composition.

[11] (A) Glycyrrhetinic acid in an amount exceeding 0.01% by mass and not exceeding 0.55% by mass, (B) 0.3% by mass or more of polyoxyethylene hydrogenated castor oil, (C) Ethanol less than 45% by mass, (D) 1.8% by mass or more of 1,3-butylene glycol, and 0.2% by mass or more of polyethylene glycol monooleate, Includes, moreover, 0.001 to 0.1% by mass of tocopherol acetate, 0.01 to 1.0% by mass of diphenhydramine hydrochloride, 0.1 to 10.0% by mass of carpronium chloride hydrate, 0.005 to 0.5% by mass of pyridoxine hydrochloride, 0.1 to 10.0% by mass of pantothenyl ethyl ether, 0.02 to 2.0% by mass of salicylic acid, 0.02 to 0.2% by mass of edetate hydrate, and / or 0.03 to 3.0% by mass of l-menthol, A scalp composition comprising

[12] (A) Glycyrrhetinic acid or a salt thereof, (B) Polyoxyethylene hydrogenated castor oil, and (C) ethanol, A method for producing a scalp composition in which precipitation of precipitates and / or insoluble matters is suppressed, comprising (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, Adding the same to the composition.

Advantages of the Invention

[0006] For a scalp composition containing at least ethanol, glycyrrhetinic acid or a salt thereof, and polyoxyethylene hydrogenated castor oil, precipitation of precipitates that occur over time can be suppressed when stored at low temperature. <​​​​​​​​​​​​​​​​​​

[0008] In this specification, the "scalp composition" means a composition to be applied to the scalp, and includes hair growth agent compositions, hair tonic compositions, and other hair care products, etc. In particular, hair growth agent compositions and hair tonic compositions are preferred. In this specification, the "hair growth agent composition" or "hair tonic composition" means a composition containing at least (A) glycyrrhetinic acid or a salt thereof as an active ingredient of the hair growth agent or hair tonic. It may contain other active ingredients in an amount that does not impair the effects of the present invention as a medicinal ingredient. Examples of other active ingredients of the hair growth agent or hair tonic include those known as hair growth components, hair tonic components, hair growth promoting components, antihistamine components, crude drug components, bactericidal components, keratolytic components, vitamin components, anti-inflammatory components, etc. The scalp composition in this specification does not necessarily need to be stored at a low temperature, but from the viewpoints of improving the effect and usability, the situation of refrigerated storage by users often occurs, so it is necessary to be a composition excellent in storage stability at low temperature. In this specification, the scalp composition is not limited, but is a composition excellent in low-temperature storage stability when stored at a temperature in the range of a relatively low temperature of about 5°C, for example, 0 to 10°C.

[0009] In the scalp composition of the present invention, from the viewpoint of activity, glycyrrhetinic acid or a salt thereof is preferably contained in an amount exceeding at least 0.01% by mass in terms of glycyrrhetinic acid, based on the total mass of the composition. It is preferably more than 0.01% by mass and 0.55% by mass or less, more preferably 0.03 to 0.45% by mass, still more preferably 0.05 to 0.35% by mass, even more preferably 0.08 to 0.20% by mass, and yet even more preferably 0.10% by mass or more and less than 0.12% by mass.

[0010] The scalp composition of the present invention contains (B) polyoxyethylene hydrogenated castor oil as a solubilizing component. Polyoxyethylene hydrogenated castor oil is hydrogenated castor oil to which ethylene oxide has been added. The number of moles of ethylene oxide added is not particularly limited, but for example, an average number of moles added of 20 to 70 is preferred, and an average number of moles added of 30 to 50 is more preferred. Polyoxyethylene hydrogenated castor oil may be used alone or in combination of two or more types. Commercially available polyoxyethylene hydrogenated castor oil may be used. Examples include polyoxyethylene hydrogenated castor oil 100, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 50, polyoxyethylene hydrogenated castor oil 40, and polyoxyethylene hydrogenated castor oil 30.Commercially available products include, for example, polyoxyethylene hydrogenated castor oil (product name: NIKKOL HCO-30, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 30), polyoxyethylene hydrogenated castor oil (product name: EMALEX HC-30, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 30), polyoxyethylene hydrogenated castor oil (product name: NIKKOL HCO-40, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (product name: EMALEX HC-40, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (product name: BLAUNON CW-40, manufactured by Aoki Oil & Fat Industry Co., Ltd., average number of moles of ethylene oxide added: 40), and polyoxyethylene hydrogenated castor oil (product name: BLAUNON Examples include RCW-40 (manufactured by Aoki Oil & Fat Industry Co., Ltd., average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (product name: Uniox HC-40, manufactured by NOF Corporation, average number of moles of ethylene oxide added: 40), polyoxyethylene hydrogenated castor oil (product name: NIKKOL HCO-50, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 50), polyoxyethylene hydrogenated castor oil (product name: EMALEX HC-50, manufactured by Nippon Emulsion Co., Ltd., average number of moles of ethylene oxide added: 50), polyoxyethylene hydrogenated castor oil (product name: BLAUNON RCW-50, manufactured by Aoki Oil & Fat Industry Co., Ltd., average number of moles of ethylene oxide added: 50), and polyoxyethylene hydrogenated castor oil (product name: NIKKOL HCO-60, manufactured by Nikko Chemicals Co., Ltd., average number of moles of ethylene oxide added: 60). In the scalp composition of the present invention, the content of polyoxyethylene hydrogenated castor oil relative to the total mass of the composition is preferably 0.3% by mass or more, more preferably 0.3 to 3.0% by mass, even more preferably 0.5 to 2.0% by mass, and even more preferably 1.0 to 1.8% by mass.

[0011] The scalp composition of the present invention contains (C) ethanol as a solvent component. In the scalp composition of the present invention, precipitation is less likely to occur when the ethanol content is 45% by mass or more relative to the total mass of the composition. However, if the ethanol content is high, skin irritation increases, and irritation symptoms such as redness and rash may occur, which is undesirable. Therefore, it is preferable that the ethanol content be less than 45% by mass. From the viewpoint of solubility of precipitates, it is preferable that it be 21% by mass or more, more preferably 25-44% by mass, and even more preferably 30-42% by mass.

[0012] The scalp composition of the present invention contains, as a solubilizing component, one or more selected from the group consisting of (D) 1,3-butylene glycol and polyethylene glycol monooleate. It may contain 1,3-butylene glycol or polyethylene glycol monooleate alone, or it may be a mixture of 1,3-butylene glycol and polyethylene glycol monooleate. Polyethylene glycol monooleate is a monooleic acid ester of polyethylene glycol (PEG), and is also called polyoxyethylene oleic acid monoester or polyethylene glycol monooleate. Commercially available polyethylene glycol monooleate may be used. The average number of repeating units of the polyethylene glycol (-OCH2CH2-) portion is, for example, 4 to 20, preferably 4 to 12, and more preferably 6 to 10. Examples of polyethylene glycol monooleate include NIKKOL MYO-6V, NIKKOL MYO-10V, and polyethylene glycol monooleate (10E.O.).

[0013] In the scalp composition of the present invention, the content of one or more substances selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, relative to the total mass of the composition, is preferably at least 1.8% by mass, more preferably 2.0% by mass or more, even more preferably 2.5% by mass or more and 25% by mass or less, and even more preferably 2.5% by mass or more and 19% by mass or less. When polyethylene glycol monooleate is used alone, it is preferable to use at least 0.2% by mass, more preferably 0.25% by mass to 6.0% by mass, and even more preferably 0.25% by mass to 5.0% by mass. Furthermore, when 1,3-butylene glycol and polyethylene glycol monooleate are used in combination, turbidity is more likely to occur. Therefore, it is preferable to use 1,3-butylene glycol at a concentration of 19% by mass or less, and polyethylene glycol monooleate at a concentration of 5.0% by mass or less, and more preferably at a concentration of 4.0% by mass or less.

[0014] The scalp composition of the present invention may, to the extent that it achieves the effects of the present invention, contain, in addition to the above-mentioned components (A) to (D), one or more of the hair growth promoting components, antihistamine components, and vitamin components, or all of them. Furthermore, it may also contain one or more of the surfactant, alcohol other than ethanol, and cooling components, or all of them. Examples of alcohols other than ethanol include lower and higher alcohols, natural alcohols, and polyhydric alcohols (glycols, glycerins, sorbitols, etc.). Specifically, alcohols other than ethanol include one selected from the group consisting of isopropanol, lauryl alcohol, myristyl alcohol, cetanol, oleyl alcohol, arachidyl alcohol, behenyl alcohol, cetostearyl alcohol, propylene glycol, 3-methyl-1,3-butanediol, diethylene glycol monoethyl ether, glycerin (concentrated glycerin, etc.), and sorbitol. Preferably, propylene glycol, 3-methyl-1,3-butanediol, and diethylene glycol monoethyl ether are used. As a cooling ingredient, substances known as cooling agents can be added. Examples of cooling agents include menthol containing l-menthol, d-menthol, and dl-menthol, peppermint oil, thymol, and camphor.

[0015] The pH of the scalp composition of the present invention is not particularly limited. For example, it may be in the range of pH 3 to 7, pH 3.5 to 6.0, or pH 4.0 to 5.5.

[0016] Examples of hair growth promoting ingredients that may be included in the scalp composition of the present invention include carpronium chloride or its hydrate, minoxidil, etc. Examples of antibacterial ingredients include hinokitiol. Examples of keratin softening ingredients include salicylic acid or its salts. Examples of antihistamine ingredients include diphenhydramine or its salts or their hydrates, chlorpheniramine or its salts or their hydrates, etc. Examples of vitamin ingredients include pantothenyl ethyl ether, pyridoxine or its salts or their hydrates, tocopherols, calcium pantothenate, etc. Examples of anti-inflammatory ingredients include glycyrrhizic acid, dipotassium glycyrrhizinate, etc. Examples of herbal ingredients include Polygonum multiflorum tincture, Panax ginseng tincture, etc. Examples of tocopherols include tocopherol, tocotrienol and their derivatives (e.g., esterified derivatives such as acetate, succinate, and nicotinate), and their salts (e.g., alkaline earth metal salts such as calcium and magnesium salts). Other active ingredients in hair growth or hair restoration products include 6-benzylaminopurine, pentadecanoic acid glyceride, resorcinol, and estradiol benzoate.

[0017] Preferably, in addition to components (A) to (D), the scalp composition of the present invention comprises at least one selected from the group consisting of carpronium chloride or its hydrate, hinokitiol, salicylic acid or its salt, pantothenyl ethyl ether, pyridoxine or its salt or its hydrate, diphenhydramine or its salt or its hydrate, and tocopherol acetate.

[0018] More preferably, the scalp composition of the present invention comprises, in addition to components (A) to (D), at least one selected from the group consisting of carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, pyridoxine hydrochloride, diphenhydramine hydrochloride, and tocopherol acetate, and more preferably, at least one selected from the group consisting of carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride. Preferably, in addition to components (A) to (D), the mixture contains carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride, or, in addition to components (A) to (D), the mixture contains carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, pyridoxine hydrochloride, diphenhydramine hydrochloride, and tocopherol acetate.

[0019] Preferably, the scalp composition of the present invention includes, in addition to components (A) to (D), at least one selected from the group consisting of carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride, or, more preferably, at least one selected from the group consisting of carpronium chloride hydrate, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride. Preferably, in addition to components (A) to (D), the mixture contains carpronium chloride hydrate, hinokitiol, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride, or, in addition to components (A) to (D), the mixture contains carpronium chloride hydrate, salicylic acid or a salt thereof, pantothenyl ethyl ether, and pyridoxine hydrochloride.

[0020] In the scalp composition of the present invention, if carpronium or its salt or hydrate is included as a hair growth promoting ingredient, the content thereof is preferably, for example, 0.1 to 10.0% by mass, more preferably 0.5 to 5.0% by mass, even more preferably 0.7 to 3.0% by mass, and still more preferably 0.8 to 2.2% by mass, based on the total mass of the composition.

[0021] In the scalp composition of the present invention, if hinokitiol is included as a bactericidal component, its content is preferably, for example, 0.005 to 0.56% by mass, more preferably 0.01 to 0.34% by mass, even more preferably 0.02 to 0.23% by mass, and still more preferably 0.04 to 0.12% by mass, based on the total mass of the composition.

[0022] In the scalp composition of the present invention, if salicylic acid or a salt thereof is included as a keratin softening component, the content thereof is preferably, for example, 0.02% by mass or more, more preferably 0.02 to 2.3% by mass, even more preferably 0.1 to 1.67% by mass, and still more preferably 0.2 to 1.2% by mass, based on the total mass of the composition.

[0023] In the scalp composition of the present invention, if pantothenyl ethyl ether is included as a vitamin component, its content is preferably, for example, 0.1 to 10.0% by mass, more preferably 0.5 to 5.0% by mass, even more preferably 0.7 to 2.0% by mass, and still more preferably 0.8 to 1.5% by mass, based on the total mass of the composition.

[0024] In the scalp composition of the present invention, if pyridoxine or its salt or hydrate is included as a vitamin component, the content thereof is preferably, for example, 0.005 to 0.5% by mass, more preferably 0.01 to 0.2% by mass, and even more preferably 0.03 to 0.1% by mass, based on the total mass of the composition.

[0025] In the scalp composition of the present invention, if diphenhydramine or a salt thereof or a hydrate thereof is included as an antihistamine component, the content thereof is preferably, for example, 0.01 to 1.0% by mass, more preferably 0.05 to 0.5% by mass, and even more preferably 0.08 to 0.2% by mass, based on the total mass of the composition.

[0026] In the scalp composition of the present invention, if tocopherols, particularly tocopherol, tocotrienol, or derivatives thereof, are included as vitamin components, the content thereof is preferably, for example, 0.001 to 0.1% by mass, more preferably 0.005 to 0.05% by mass, and even more preferably 0.008 to 0.02% by mass, based on the total mass of the composition.

[0027] Examples of surfactants in the scalp composition of the present invention include nonionic surfactants, cationic surfactants, and amphoteric surfactants.

[0028] Examples of nonionic surfactants include propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan beeswax, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyalkylene sterols, polyethylene glycol fatty acid esters, and the like. Specifically, one or more selected from polysorbate 85, polysorbate 60, polysorbate 65, polysorbate 80, polysorbate 20, etc., are preferred. More preferably, polysorbate 80 is used.

[0029] In the scalp composition of the present invention, if a surfactant (excluding polyoxyalkylene hydrogenated castor oil) is included, its content is preferably 0.06 to 6.0% by mass, more preferably 0.1 to 3.0% by mass, and even more preferably 0.3 to 2.5% by mass, based on the total mass of the composition. In the scalp composition of the present invention, if polyoxyethylene sorbitan fatty acid ester, preferably polysorbate 80, is included, its content is preferably 0.04 to 4.0% by mass, more preferably 0.1 to 2.0% by mass, and even more preferably 0.2 to 0.8% by mass, based on the total mass of the composition.

[0030] The scalp composition of the present invention may contain an edetate as a chelating agent. In this specification, "edetate" also includes its hydrate form. Examples of edetates include sodium edetate hydrate (more precisely, disodium ethylenediaminetetraacetate dihydrate; also referred to as edetate Na hydrate), disodium edetate, tetrasodium edetate, calcium edetate, calcium disodium edetate, etc., and include their hydrates. The edetate content is preferably 0.02% by mass or more relative to the total volume of the composition, more preferably 0.02 to 0.2% by mass, more preferably 0.02 to 0.15% by mass, and even more preferably 0.03 to 0.1% by mass.

[0031] More preferably, the scalp composition of the present invention, in addition to the above-mentioned components (A) to (D), contains carpronium chloride hydrate as a hair growth promoting component, hinokitiol as a bactericidal component, salicylic acid as a keratolytic component, and at least one selected from the group consisting of pantothenyl ethyl ether, pyridoxine hydrochloride, and / or tocopherol acetate as a vitamin component. Alternatively, in addition to the above-mentioned components (A) to (D), it is preferable to contain carpronium chloride hydrate as a hair growth promoting component, hinokitiol as a bactericidal component, salicylic acid as a keratolytic component, diphenhydramine hydrochloride as an antihistamine component, and at least one selected from the group consisting of pantothenyl ethyl ether, pyridoxine hydrochloride, and / or tocopherol acetate as a vitamin component. More preferably, the scalp composition of the present invention is a composition comprising, based on the total mass of the composition, (A) 0.03 to 0.55% by mass of glycyrrhetinic acid or a salt thereof in terms of glycyrrhetinic acid, (B) 0.3% by mass or more of polyoxyethylene hydrogenated castor oil, (C) less than 45% by mass of ethanol, (D) 2.0 to 25% by mass of 1,3-butylene glycol, and / or 0.2 to 6.0% by mass of polyethylene glycol monooleate.

[0032] Furthermore, the scalp composition of the present invention is preferably, (A) Glycyrrhetinic acid exceeding 0.01% by mass and not exceeding 0.55% by mass, (B) 0.3% by mass or more of polyoxyethylene hydrogenated castor oil, (C) Ethanol less than 45% by mass, (D) 1.8% by mass or more of 1,3-butylene glycol, and 0.2% by mass or more of polyethylene glycol monooleate, Includes, moreover, 0.001 to 0.1% by mass of tocopherol acetate, 0.01-1.0% by mass of diphenhydramine hydrochloride, 0.1 to 10.0% by mass of carpronium chloride hydrate, 0.005-0.5% by mass of pyridoxine hydrochloride, 0.1 to 10.0% by mass of pantothenyl ethyl ether, 0.02-2.0% by mass of salicylic acid, 0.02 to 0.2% by mass of edetate hydrate, and / or 0.03-3.0% by mass of l-menthol, Includes.

[0033] The scalp composition of the present invention may be in any form, such as a liquid, spray, gel, cream, aerosol, or foam.

[0034] The scalp composition of the present invention can be manufactured by appropriately mixing the components using conventionally known methods. Another aspect of the present invention is a method for producing a scalp composition, comprising mixing at least (A) to (D). The method may optionally further include mixing other components. The order in which components (A) to (D) and other components are added is not particularly limited.

[0035] Other embodiments of the present invention include the following methods. (A) Glycyrrhetinic acid or its salt, (B) Polyoxyethylene hydrogenated castor oil, and (C) Ethanol, A method for preventing the precipitation of precipitates and / or insoluble matter in a scalp composition containing, (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, The method comprising adding to the composition.

[0036] Other embodiments of the present invention include the following methods. (A) Glycyrrhetinic acid or its salt, (B) Polyoxyethylene hydrogenated castor oil, and (C) Ethanol, A method for producing a scalp composition containing, in which the precipitation of precipitates and / or insoluble matter is suppressed, (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, The method comprising adding to the composition. While scalp compositions containing (A) to (C) tend to develop precipitates over time during storage, especially when stored at low temperatures, adding (D) one or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate can prevent the precipitation of precipitates and / or insoluble matter, and can produce scalp compositions in which the precipitation of precipitates and / or insoluble matter is suppressed. [Examples]

[0037] Reference example A pre-treatment solution was prepared by dissolving glycyrrhetinic acid in ethanol. This pre-treatment solution was then mixed with polyoxyethylene hydrogenated castor oil (NIKKOL HCO40), ethanol, and water in the amounts shown in Table 1. This solution was filled into a glass container with a lid and left to stand in the dark at 5°C. The state of precipitation, such as insoluble matter or precipitates, was evaluated as described below. The evaluation was carried out for 12 days.

[0038] <Evaluation Criteria for Precipitates> The state of precipitation of insoluble matter or precipitates was visually evaluated and classified into the following six states. Colorless and transparent: The solution is colorless, clear, and allows observation of what is on the other side. Milky white transparent: Slightly white in color, but clear enough to observe what's on the other side of the solution without any cloudiness. Cloudiness: The solution becomes uniformly cloudy white, making it impossible to see through it. Non-uniform: A condition in which there is a non-uniform white turbidity or hazy turbidity. Insoluble matter: A state in which solid precipitates are suspended in the water. Precipitation: A state in which solid precipitates settle below half the height of the solution. For samples labeled "colorless and transparent" and "milky white and transparent," no precipitates were observed, and the "evaluation" was indicated as "A" in the table showing the experimental results. The "state" of the precipitate was indicated as "-". For "turbidity" and "heterogeneity," no solid precipitates were observed visually, and the "evaluation" was indicated as "B" in the table showing the experimental results. The "state" of the precipitate was indicated as "turbidity" and "heterogeneity." "Insoluble matter" and "precipitate" indicate the presence of solid precipitates, and are evaluated as "C" in the table showing the experimental results. The "state" of the precipitate is indicated as "insoluble matter" or "precipitate." The first day of standing was designated as day 0, and the number of days until "turbidity," "heterogeneity," "insoluble matter," or "precipitation" was observed was defined as "precipitation days."

[0039] Table 1A JPEG2026060941000001.jpg74170

[0040] Table 1B JPEG2026060941000002.jpg74170

[0041] As can be seen from the reference example in Table 1A, when ethanol is at a concentration of 30%, compositions prepared by mixing glycyrrhetinic acid, polyoxyethylene hydrogenated castor oil (NIKKOL HCO40), 1,3-butylene glycol (1,3-BG), and polyethylene glycol monooleate (MYO-6V) at constant concentrations showed precipitation or insoluble matter within 12 days. As can be seen from the reference example in Table 1B, glycyrrhetinic acid becomes more soluble at a 44% ethanol concentration, but turbidity occurs when polyethylene glycol monooleate (MYO-6V) or MYO-6V is mixed with 1,3-butylene glycol (1,3-BG).

[0042] Examples When 1,3-butylene glycol (1,3-BG) or polyethylene glycol monooleate (MYO-6V) was added to the composition of Reference Example B4 in Table 1A at 2% by mass or 0.2% by mass, respectively, the insoluble matter disappeared in both cases (Table 2, Examples A and B). In the following examples, the formulations were all adjusted to pH 4.7 with an aqueous sodium hydroxide solution or hydrochloric acid (the amount is contained in the water (remainder)).

[0043] Table 2 JPEG2026060941000003.jpg74170

[0044] Based on the results of Example A in Table 2, the state of precipitates was evaluated by changing only the amount of 1,3-butylene glycol added (Table 3). No precipitates formed when the amount of 1,3-butylene glycol added was 2.0% or more (Examples 1-2). On the other hand, insoluble matter was formed when the amount of 1,3-butylene glycol added was 1.5% by mass or less (Comparative Examples 1-2).

[0045] Table 3 JPEG2026060941000004.jpg74170

[0046] Based on the results of Example B in Table 2, the state of precipitates was evaluated by varying the amount of polyethylene glycol monooleate added alone (Table 4). No precipitation occurred when the amount of polyethylene glycol monooleate added was 0.20 to 4.0% by mass (Examples 3 to 6). On the other hand, insoluble matter was formed when the amount of polyethylene glycol monooleate added was 0.15% by mass or less (Comparative Examples 3 to 4). Furthermore, turbidity occurred when 6.0% by mass of polyethylene glycol monooleate was used and 18% by mass of 1,3-butylene glycol was used (Example 7).

[0047] Table 4 JPEG2026060941000005.jpg74155

[0048] The state of precipitates was evaluated by varying the combined amounts of 1,3-butylene glycol and polyethylene glycol monooleate (Table 5). When 4.0% by mass of polyethylene glycol monooleate and 10-18% by mass of 1,3-butylene glycol were used, no precipitation occurred (Examples 8-10), while when 20% by mass or more of 1,3-butylene glycol was used, turbidity occurred (Examples 11-12).

[0049] Table 5 JPEG2026060941000006.jpg74155

[0050] When 1,3-butylene glycol and polyethylene glycol monooleate were added in combination, the state of precipitates was evaluated by varying the amount of glycyrrhetinic acid added (Table 6). When 4.0% by mass of polyethylene glycol monooleate and 10% by mass of 1,3-butylene glycol were used, no precipitation occurred when the amount of glycyrrhetinic acid added was in the range of 0.15 to 0.50% by mass (Examples 13 to 17), but when 0.60% by mass or more of glycyrrhetinic acid was used, precipitates were formed (Comparative Examples 5 to 7).

[0051] Table 6 JPEG2026060941000007.jpg74158

[0052] The state of precipitates was evaluated by varying the amount of glycyrrhetinic acid added when 1,3-butylene glycol (2% by mass) or polyethylene glycol monooleate (0.2% by mass) was added alone (Tables 7 and 8). In both cases of 1,3-butylene glycol (2% by mass) or polyethylene glycol monooleate (0.2% by mass), no precipitate formed when the amount of glycyrrhetinic acid added was 0.11% by mass or less (Examples 18-20 and 21-23), while insoluble matter or precipitate formed when the amount of glycyrrhetinic acid added exceeded 0.12% by mass (Reference Examples 11-14, Reference Examples 15-18). These results suggest that the insoluble matter or precipitate may be derived from glycyrrhetinic acid. Furthermore, when the amount of 1,3-butylene glycol or polyethylene glycol monooleate is changed or used in combination, precipitation does not occur in the range of glycyrrhetinic acid amount from 0.15% by mass to less than 0.60% by mass (see Examples 8-17). Therefore, these experimental results are considered as reference examples in this experiment.

[0053] Table 7 JPEG2026060941000008.jpg74155

[0054] Table 8 JPEG2026060941000009.jpg74155

[0055] In combination of 1,3-butylene glycol and polyethylene glycol monooleate, the amount of polyoxyethylene hydrogenated castor oil added was varied, and the state of precipitates was evaluated (Table 9). When the amount of polyoxyethylene hydrogenated castor oil added was 0.2% by mass, insoluble matter was observed (Comparative Example 8). On the other hand, when the amount of polyoxyethylene hydrogenated castor oil added was 0.3% by mass or more, no precipitates such as sediment were observed (Examples 24-26).

[0056] Table 9 JPEG2026060941000010.jpg74170

[0057] In the combined use of 1,3-butylene glycol and polyethylene glycol monooleate, the amount of ethanol added was varied, and the state of the precipitate was evaluated (Table 10). When the amount of ethanol added was 21% by mass, a heterogeneous state was observed (Example 27), but when the amount was 30% by mass or more, no precipitate or other precipitation was observed (Examples 28-29). Compositions with further variations in the amounts of 1,3-butylene glycol and polyethylene glycol monooleate, as well as the amount of ethanol added, were also investigated, but no precipitate or other precipitation was observed in any of them (Examples 30-32).

[0058] Table 10 JPEG2026060941000011.jpg73134

[0059] Manufacturing Example 1 Preparation F0, containing at least glycyrrhetinic acid, polyoxyethylene hydrogenated castor oil 40, ethanol, carpronium chloride hydrate, hinokitiol, salicylic acid or its salt, pantothenyl ethyl ether, pyridoxine hydrochloride, diphenhydramine hydrochloride, and tocopherol acetate, and preparations F1 to F3 (all adjusted to pH 4.7), further containing 1,3-butylene glycol and polyethylene glycol monooleate, were prepared. Each solution was filled into a glass container with a lid and left to stand in the dark at 5°C. The state of precipitation, such as insoluble matter or precipitate, was evaluated according to the <Evaluation Criteria for Precipitates> described above. In preparation F0, which did not contain 1,3-butylene glycol and polyethylene glycol monooleate, precipitate formed within 6 days of storage. On the other hand, no precipitation was observed in preparations F1 to F3, which contained 1,3-butylene glycol and polyethylene glycol monooleate. The results of these manufacturing examples are consistent with the results of the examples / comparative examples / reference examples.

[0060] Table 11 JPEG2026060941000012.jpg123170

[0061] Manufacturing Example 2 Formulations F4 and F5 (both adjusted to pH 4.7), containing glycyrrhetinic acid, polyoxyethylene hydrogenated castor oil 40, ethanol, 1,3-butylene glycol and polyethylene glycol monooleate, carpronium chloride hydrate, pyridoxine hydrochloride, pantothenyl ethyl ether, hinokitiol, and salicylic acid, as described in Table 12, were filled into glass containers with lids and left to stand in the dark at 5°C. After 1 week and 4 weeks, the state of precipitation, such as insoluble matter or precipitates, was evaluated according to the <Evaluation Criteria for Precipitates> described above. No precipitation was observed in formulations F4 and F5 until 4 weeks later. The results of these manufacturing examples are consistent with the results of the Examples / Comparative Examples / Reference Examples.

[0062] Table 12 JPEG2026060941000013.jpg122145

[0063] Manufacturing Example 3 Preparations were manufactured according to the formulations listed in Table 13. All preparations were adjusted to a pH of 4.7.

[0064] Table 13 JPEG2026060941000014.jpg107170

Claims

1. (A) Glycyrrhetinic acid or its salt, (B) Polyoxyethylene hydrogenated castor oil, (C) Ethanol, and (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, A scalp composition containing the following:

2. The scalp composition according to claim 1, which is a hair growth agent or hair restoration agent composition.

3. The scalp composition according to claim 1, wherein the content of (D) 1,3-butylene glycol is 1.8% by mass or more, and / or the content of polyethylene glycol monooleate is 0.2% by mass or more, based on the total mass of the scalp composition.

4. The scalp composition according to claim 1, wherein the content of (B) polyoxyethylene hydrogenated castor oil is 0.3% by mass or more based on the total mass of the scalp composition.

5. The scalp composition according to claim 1, wherein the content of (A) glycyrrhetinic acid or a salt thereof, relative to the total mass of the scalp composition, is greater than 0.01% by mass and less than or equal to 0.55% by mass when converted to glycyrrhetinic acid.

6. The scalp composition according to claim 1, wherein the content of (C) ethanol relative to the total mass of the scalp composition is less than 45% by mass.

7. The scalp composition according to claim 1, comprising, in addition to components (A) to (D), at least one selected from the group consisting of carpronium chloride or its hydrate, hinokitiol, salicylic acid or its salt, pantothenyl ethyl ether, pyridoxine or its salt or its hydrate, diphenhydramine or its salt or its hydrate, and tocopherol acetate.

8. (A) Glycyrrhetinic acid or its salt, (B) Polyoxyethylene hydrogenated castor oil, and (C) Ethanol, A method for preventing the precipitation of precipitates and / or insoluble matter in a scalp composition containing, (D) One or more selected from the group consisting of 1,3-butylene glycol and polyethylene glycol monooleate, The method comprising adding to the composition.

9. A method for producing a scalp composition according to any one of claims 1 to 7, comprising mixing (A), (B), (C), and (D).

10. The method according to claim 8, wherein the scalp composition is a hair growth agent or hair restoration agent composition.

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