System and method for safety syringes

Abstract

To provide a suitable system and method for safety syringes. [Solution] One embodiment relates to a system for injection, the system comprising: a syringe body defining an internal drug chamber; a stopper member configured to be inserted into the internal drug chamber to contain a drug within the drug chamber; a plunger member configured to be manually operated to insert the stopper member into the syringe body; and a needle having a proximal and distal end, wherein the proximal end has an anchor geometry configured to be at least partially inserted into the stopper member, thereby pulling the needle proximal together with the stopper when the stopper member is retracted, thereby at least partially containing it within the internal drug chamber.

Description

Technical Field

[0001] Related Application Data This application claims the benefit of U.S. Provisional Patent Application No. 61 / 984,033, filed Apr. 24, 2014; U.S. Provisional Patent Application No. 62 / 014,035, filed Jun. 18, 2014; U.S. Provisional Patent Application No. 62 / 059,110, filed Oct. 2, 2014; U.S. Provisional Patent Application No. 62 / 105,717, filed Jan. 20, 2015; U.S. Provisional Patent Application No. 62 / 117,672, filed Feb. 18, 2015; and U.S. Provisional Patent Application No. 62 / 150,761, filed Apr. 21, 2015, under 35 U.S.C. § 119. The foregoing applications are hereby incorporated by reference in their entirety.

[0002] The present invention generally relates to injection systems, devices, and processes for facilitating various levels of control over fluid injection, and more particularly, to systems and methods related to safety syringes in a medical environment.

Background Art

[0003] Numerous syringes, such as those shown in Figure 1A(2), are consumed daily in the healthcare setting. A typical syringe (2) comprises a tubular body (4), a plunger (6), and a needle (8). As shown in Figure 1B, such syringes (2) can be used not only to inject fluids into patients but also to draw or release fluids from or into containers such as drug bottles, vials, bags, or other drug containment systems (10). In fact, due to regulatory constraints in some countries, such as the United States, and concerns about maintaining sterility, when drug bottles (10) are used with syringes (2) as seen in certain patient settings, such drug bottles may have to be discarded after use for only a single patient, generating medical waste from the bottles and remaining medication, and further contributing to the regular shortage of certain essential drugs. Referring to Figure 2A, three Luer syringes (12) are shown, each having a distally positioned Luer-fit geometry (14) so ​​that they can be connected to other devices having similar fitting geometry, such as the Luer manifold assembly (16) shown in Figure 2B. The Luer-fit (14) of the syringe in Figure 2A may be called the "male" Luer-fit, while the one in Figure 2B (18) may be called the "female" Luer-fit. One of the Luer-fits may have threads (in which case this configuration may be called a "Luer-lock" configuration), so that the two sides can be connected by relative rotation, which may be combined with compressive load. In other words, in one embodiment of the Luer-lock, rotation may be used in conjunction with compression to engage the threads into the male-fit, which in turn engages its flange onto the female-fit, bringing the devices together into a fluid-seal connection. In another embodiment, a tapered joint geometry may be used to provide a compression-based Luer engagement without threads or rotation (such a configuration may be referred to as a “slip-on” or “conical” Luer configuration). While such Luer connections are considered relatively safe for the operator, there is a risk of drug spillage / leakage and breakage of the components under load to provide the Luer connection. On the other hand, the use of needle injection configurations carries the risk of the sharp needle coming into contact with or piercing a person or undesirable structure.For this reason, so-called "safety syringes" were developed.

[0004] One embodiment of the safety syringe (20) is shown in Figure 3, in which a tubular shielding member (22) is spring-driven to cover the needle (8) when released from the locked position relative to the syringe body (4). Another embodiment of the safety syringe (24) is shown in Figures 4A-4B. In this configuration, after the plunger (6) is fully inserted into the syringe body (4), the retractable needle (26) is configured to retract (28, 26) back into a safe position within the tubular body (4), as shown in Figure 4B. Such a configuration, which is configured to collapse on its own, may be associated with problems of blood splashing / aerosolization, safe storage of preload energy that could malfunction and start before the desired time, reduced accuracy in administering the total dose due to residual dead space in the spring compression volume, and / or reduced retraction speed control which may be associated with pain and patient anxiety.

[0005] Further complicating the syringe market is the increasing demand for pre-filled syringe assemblies, such as those shown in Figures 5A and 5B, which generally comprise a syringe body or "drug containment and delivery system" (34), a plunger tip, plug, or stopper (36), and a distal seal or cap (35) that can be fitted onto a Luer connector (Figure 5A shows the cap 35 in position, and Figure 5B illustrates the Luer connector 14 with the cap removed). The drug solution may reside in the volume between the distal seal and the distal end (37) of the plunger tip (36) or in the drug storage section (40). The plunger tip (36) may include a standard butyl rubber material and may be coated with a biocompatible smooth coating or the like to facilitate a preferred seal and relative movement to the associated syringe body structure and materials. The proximal end of the syringe body (34) in Figure 5B includes a conventional syringe flange (38), such as one known as a "Gerresheimer" flange configuration. The syringe body (34) preferably comprises a translucent material such as glass or polymer. The plunger tip (36) may be positioned within the syringe body (34) to form a volume within the drug chamber or storage section (40) and to facilitate the discharge of the associated fluid through the needle. The syringe body may define a substantially cylindrical shape (i.e., so that the plunger tip 36 having a circular cross-sectional shape can establish a seal with the syringe body), or it may be configured to have other cross-sectional shapes such as an ellipse.

[0006] Such assemblies are desirable because they can be standardized and manufactured in precise volumes by a small number of manufacturers worldwide, ensuring they meet all the ever-changing global regulations regarding filling, packaging, and the selection of pharmaceutical / drug bonding materials and component use. However, such simple configurations will generally not meet the emerging global standards for single use, safety, auto-deactivation, and needle-stick resistance. For this reason, some suppliers have moved to more “longitudinal” solutions, such as (41) discussed in Figure 5C, attempting to meet all or at least some of the standards with a single solution, and as a result of attempting to meet these standards for many different scenarios, such products may have significant limitations (including some of those mentioned above with reference to Figures 3-4B), relatively high inventory, and utilization costs.

[0007] An improved injection system is needed that addresses the shortcomings of currently available configurations. In particular, a safety syringe solution is needed that can utilize the existing and relatively well-controlled supply chain of conventionally delivered pre-filled syringe assemblies, such as those described with reference to Figures 5A-5B. The present invention provides, for example, the following: (Item 1) It is a system for injection, a. Syringe body and distal needle connection part defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is detachably connected to the distal needle joint of the syringe body, and the plunger locking member is at least partially retractable into the internal drug chamber when the plunger member is operated relative to the syringe body in order to switch the plunger locking member from a locked state to an unlocked state, and the plunger locking member is interconnected between the syringe body and the plunger member, A system in which the plunger locking member is disposed within a lumen substantially defined by the plunger member. (Item 2) The system described in item 1, wherein the syringe body includes a commercially available syringe body. (Item 3) The system according to item 1, wherein the syringe body generally has a cylindrical geometric shape. (Item 4) The system according to item 1, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 5) The system according to item 4, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 6) The system according to item 1, wherein the syringe body includes a glass material. (Item 7) The system according to item 1, wherein the syringe body comprises a polymer material. (Item 8) The system according to item 7, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 9) The system described in item 1, wherein the syringe body contains metal. (Item 10) The system according to item 1, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 11) The system according to item 10, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 12) The system according to item 10, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 13) The system described in item 1, wherein the syringe body defines the distal drug port. (Item 14) The system according to item 13, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 15) The system according to item 14, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 16) The system according to item 15, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 17) The system according to item 1, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 18) The system according to item 1, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 19) The system according to item 18, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 20) The system according to item 1, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 21) The system according to item 1, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 22) The system according to item 1, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 23) The system according to item 22, wherein the sealing coating includes a PTFE film. (Item 24) The system according to item 1, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 25) The system according to item 24, wherein the lubricant layer contains silicone oil. (Item 26) The system according to item 1, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 27) The system according to item 26, wherein the stopper member comprises an unmodified solid compliant member having no recess or protrusion for connection to the needle. <  (Item 28) The system according to item 1, wherein the needle comprises at least one radially protruding locking surface mechanism. (Item 29) The system according to item 28, wherein the proximal end of the needle comprises at least one through element positioned proximally to at least one anchor element. (Item 30) The system according to item 29, wherein the through element has a pointed tip. (Item 31) The system according to item 30, wherein the through element has a solid structure and has no lumen or aperture defined therethrough, and comprises a solid structure. (Item 32) The system according to item 29, wherein the needle defines an injection passage therethrough, and the injection passage is selected to communicate from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 33) The system according to item 28, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 34) The system according to item 33, wherein the cannula member and the hub member are formed from the same piece of material. (Item 35) The system according to item 33, wherein the cannula member and the hub member are separately formed elements that are fixed and connected together to form a part of the needle. (Item 36) The system according to item 33, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 37) The system according to item 35, wherein the hub member is formed from a single piece of tubular material. (Item 38) The system according to item 33, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 39) The system according to item 32, wherein the cannula component includes metal. (Item 40) The system according to item 32, wherein the hub is made of metal or plastic material. (Item 41) The aforementioned proximal member, made of metal or plastic material, the system as described in item 32. (Item 42) The system according to item 1, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 43) The system according to item 42, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 44) The system according to item 43, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 45) The system according to item 44, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 46) The system according to item 45, wherein the predetermined insertion position is the position in which the stopper is positioned in a fully inserted state relative to the syringe body. (Item 47) The system according to item 42, wherein the energy storage member is a spring. (Item 48) The system according to item 47, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 49) The system according to item 47, wherein the spring comprises an elastomeric polymer. (Item 50) The system according to item 49, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 51) The system according to item 42, wherein the energy storage member includes a solid pellet member. (Item 52) The system according to item 51, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubber. (Item 53) The system according to item 47, wherein the spring comprises a single, generally helical coil. (Item 54) The system according to item 47, wherein the spring comprises a plurality of generally helical coils. (Item 55) The system according to item 54, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 56) The system according to item 54, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 57) The system described in item 55, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 58) The system according to item 57, wherein the helical coils, which are aligned coaxially and parallel to each other in the longitudinal direction, are wound helically in opposite winding directions to each other so as to prevent interference between the coils when they are compressed. (Item 59) The system according to item 42, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 60) The system according to item 1, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 61) The system according to item 1, further comprising a plunger distal end threaded joint, wherein the plunger is spirally inserted into the stopper member and connected to the stopper member by such insertion. (Item 62) The system according to item 1, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 63) The system according to item 62, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member is fully inserted into the syringe body. (Item 64) The system according to item 62, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 65) The system according to item 44, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 66) The system according to item 1, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 67) The system according to item 66, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 68) The system according to item 67, wherein the braking member comprises a plate aperture braking section. (Item 69) The system according to item 68, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 70) The system according to item 68, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 71) The system according to item 70, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 72) The system according to item 67, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 73) The system according to item 72, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 74) The system according to item 72, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 75) The system according to item 73, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 76) The system according to item 74, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 77) The system according to item 66, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 78) The system according to item 77, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 79) The system according to item 1, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 80) The system according to item 79, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 81) The system according to item 80, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 82) The system according to item 81, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 83) The system according to item 81, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 84) The system according to item 79, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 85) The system according to item 1, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 86) The system according to item 85, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 87) The system according to item 1, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 88) The system according to item 1, wherein the plunger member is configured to be manually retracted by an operator when the plunger locking member is in an unlocked state. (Item 89) The system according to item 88, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 90) The system according to item 88, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 1) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end has an anchor geometry configured such that when the stopper member is retracted, the needle is pulled proximal together with the stopper and at least partially housed within the internal drug chamber. (Item 2) The system described in item 1, wherein the syringe body includes a commercially available syringe body. (Item 3) The system according to item 1, wherein the syringe body generally has a cylindrical geometric shape. (Item 4) The system according to item 1, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 5) The system according to item 4, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 6) The system according to item 1, wherein the syringe body includes a glass material. (Item 7) The system according to item 1, wherein the syringe body comprises a polymer material. (Item 8) The system according to item 7, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 9) The system described in item 1, wherein the syringe body contains metal. (Item 10) The system according to item 1, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 11) The system according to item 10, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 12) The system according to item 10, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 13) The system described in item 1, wherein the syringe body defines the distal drug port. (Item 14) The system according to item 13, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 15) The system according to item 14, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 16) The system according to item 15, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 17) The system according to item 1, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 18) The system according to item 1, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 19) The system according to item 18, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 20) The system according to item 1, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 21) The system according to item 1, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 22) The system according to item 1, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 23) The system according to item 22, wherein the sealing coating includes a PTFE film. (Item 24) The system according to item 1, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 25) The system according to item 24, wherein the lubricant layer contains silicone oil. (Item 26) The system according to item 1, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 27) The system according to item 26, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 28) The system according to item 1, wherein the needle comprises at least one radially protruding locking surface mechanism. (Item 29) The system according to item 28, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 30) The system according to item 29, wherein the through-element has a pointed tip. (Item 31) The system according to item 30, wherein the through element is a solid structure and has no lumen or aperture defined through it. (Item 32) The system according to item 29, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 33) The system according to item 28, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 34) The system according to item 33, wherein the cannula member and the hub member are formed from the same material piece. (Item 35) The system according to item 33, wherein the cannula member and the hub member are separately formed elements that are fixed and connected together to form a part of the needle. (Item 36) The system according to item 33, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 37) The system according to item 35, wherein the hub member is formed from a single piece of tubular material. (Item 38) The system according to item 33, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 39) The system according to item 36, wherein the cannula component includes metal. (Item 40) The system according to item 36, wherein the hub comprises a metal or plastic material. (Item 41) The aforementioned proximal member, made of metal or plastic material, the system as described in item 36. (Item 42) The system according to item 1, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 43) The system according to item 42, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 44) The system according to item 43, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 45) The system according to item 44, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 46) The system according to item 45, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 47) The system according to item 42, wherein the energy storage member is a spring. (Item 48) The system according to item 47, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 49) The system according to item 47, wherein the spring comprises an elastomeric polymer. (Item 50) The system according to item 49, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 51) The system according to item 42, wherein the energy storage member includes a solid pellet member. (Item 52) The system according to item 51, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubber. (Item 53) The system according to item 47, wherein the spring comprises a single, generally helical coil. (Item 54) The system according to item 47, wherein the spring comprises a plurality of generally helical coils. (Item 55) The system according to item 54, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 56) The system according to item 54, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 57) The system described in item 55, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 58) The system according to item 57, wherein the helical coils, which are aligned coaxially and parallel to each other in the longitudinal direction, are wound helically in opposite winding directions to each other so as to prevent interference between the coils when they are compressed. (Item 59) The system according to item 42, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 60) The system according to item 1, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 61) The system according to item 1, further comprising a plunger distal end threaded joint, wherein the plunger is spirally inserted into the stopper member and connected to the stopper member by such insertion. (Item 62) The system according to item 1, wherein the plunger member comprises one or more ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 63) The system according to item 62, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member is fully inserted into the syringe body. (Item 64) The system according to item 62, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with one or more ratchet mechanisms, and a proximal joint that can engage with the handle portion of the syringe body. (Item 65) The system according to item 44, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 66) The system according to item 1, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 67) The system according to item 66, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 68) The system according to item 67, wherein the braking member comprises a plate aperture braking section. (Item 69) The system according to item 68, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 70) The system according to item 68, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 71) The system according to item 70, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 72) The system according to item 67, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 73) The system according to item 72, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 74) The system according to item 72, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 75) The system according to item 73, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 76) The system according to item 74, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 77) The system according to item 66, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 78) The system according to item 77, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 79) The system according to item 1, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 80) The system according to item 79, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 81) The system according to item 80, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 82) The system according to item 81, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 83) The system according to item 81, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 84) The system according to item 79, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 85) The system according to item 1, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 86) The system according to item 85, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 87) The system according to item 1, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 88) The system according to item 1, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 89) The system according to item 88, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 90) The system according to item 88, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 91) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, e. A system comprising a connecting member operably connected to a syringe body and a needle, the connecting member having a first state in which the needle is detachably connected to the syringe body, and a second state in which the needle can be freely stored relative to the syringe body. (Item 92) The system according to item 91, wherein the connecting member is further configured to have a third state in which the needle is mechanically prevented from further insertion into the syringe body. (Item 93) The system described in item 91, wherein the syringe body includes a commercially available syringe body. (Item 94) The system according to item 91, wherein the syringe body generally has a cylindrical geometric shape. (Item 95) The system according to item 91, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 96) The system according to item 95, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 97) The system according to item 91, wherein the syringe body includes a glass material. (Item 98) The system according to item 91, wherein the syringe body comprises a polymer material. (Item 99) The system according to item 98, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 100) The system according to item 91, wherein the syringe body contains metal. (Item 101) The system according to item 91, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 102) The system according to item 101, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 103) The system according to item 101, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 104) The system according to item 91, wherein the syringe body defines the distal drug port. (Item 105) The system according to item 104, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 106) The system according to item 105, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 107) The system according to item 106, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 108) The system according to item 91, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 109) The system according to item 91, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 110) The system according to item 109, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 111) The system according to item 101, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 112) The system according to item 91, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 113) The system according to item 91, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 114) The system according to item 113, wherein the encapsulant coating includes a PTFE film. (Item 115) The system according to item 91, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 116) The system according to item 115, wherein the lubricating layer contains silicone oil. (Item 117) The system according to item 91, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 118) The system according to item 117, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 119) The system according to item 101, wherein the needle comprises at least one radially protruding locking surface mechanism. (Item 120) The system according to item 119, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 121) The system according to item 120, wherein the through-element has a pointed tip. (Item 122) The system according to item 121, wherein the through-element is a solid structure and has no lumen or aperture defined through it. (Item 123) The system according to item 120, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 124) --The system according to item 116, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 125) The system according to item 124, wherein the cannula member and the hub member are formed from the same material piece. (Item 126) The system according to item 124, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 127) The system according to item 124, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 128) The system according to item 126, wherein the hub member is formed from a single piece of tubular material. (Item 129) The system according to item 124, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 130) The system according to item 127, wherein the cannula component includes metal. (Item 131) The system according to item 127, wherein the hub comprises a metal or plastic material. (Item 132) The aforementioned proximal member, made of metal or plastic material, the system as described in item 127. (Item 133) The system according to item 91, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 134) The system according to item 133, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 135) The system according to item 134, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 136) The system according to item 135, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 137) The system according to item 136, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 138) The system according to item 133, wherein the energy storage member is a spring. (Item 139) The system according to item 138, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 140) The system according to item 138, wherein the spring comprises an elastomeric polymer. (Item 141) The system according to item 140, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 142) The system according to item 133, wherein the energy storage member includes a solid pellet member. (Item 143) The system according to item 142, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 144) The system described in item 138, wherein the spring comprises a single, generally helical coil. (Item 145) The system according to item 138, wherein the spring comprises a plurality of generally helical coils. (Item 146) The system according to item 145, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 147) The system according to item 145, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 148) The system described in item 146, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 149) The system according to item 148, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 150) The system according to item 91, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 151) The system according to item 91, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 152) The system according to item 91, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 153) The system according to item 91, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 154) The system according to item 153, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 155) The system according to item 153, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 156) The system according to item 135, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 157) The system according to item 91, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 158) The system according to item 157, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 159) The system according to item 158, wherein the braking member comprises a plate aperture braking section. (Item 160) The system according to item 159, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 161) The system according to item 159, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 162) The system according to item 161, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 163) The system according to item 158, wherein the retraction of the plunger member is facilitated by the application of a retraction start load in the second mode. (Item 164) The system according to item 163, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 165) The system according to item 163, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 166) The system according to item 164, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 167) The system according to item 165, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 168) The system according to item 157, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 169) The system according to item 168, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 170) The system according to item 91, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 171) The system according to item 170, wherein the needle covering member is detachably connected to the needle by at least one snap-over type locking joint. (Item 172) The system according to item 171, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 173) The system according to item 172, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 174) The system according to item 172, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 175) The system according to item 170, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly radiating protruding surfaces. (Item 176) The system according to item 91, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 177) The system according to item 176, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 178) The system according to item 91, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 179) The system according to item 91, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 180) The system according to item 179, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 181) The system according to item 179, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 182) It is a system for injection, a. Syringe body defining the internal drug chamber, and distal needle connection, b. A stopper member having a proximal end and a distal end, configured to be inserted into the internal drug chamber to house the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is connected to the distal needle joint of the syringe body, A system wherein the distal end of the stopper member is configured not to have a pre-formed needle coupling mechanism. (Item 183) The system according to item 182, wherein the distal end of the stopper member is configured to have a distal surface shape selected from the group consisting of a convex shape, a concave shape, a flat shape, and a conical shape. (Item 184) The system described in item 182, wherein the syringe body includes a commercially available syringe body. (Item 185) The system according to item 182, wherein the syringe body generally has a cylindrical geometric shape. (Item 186) The system according to item 182, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 187) The system according to item 186, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 188) The system according to item 182, wherein the syringe body includes a glass material. (Item 189) The system according to item 182, wherein the syringe body comprises a polymer material. (Item 190) The system according to item 189, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 191) The system described in item 182, wherein the syringe body contains metal. (Item 192) The system according to item 182, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 193) The system according to item 192, wherein the syringe body, and the distal outer geometry of the syringe body, includes a Luer lock joint. (Item 194) The system according to item 192, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 195) The system described in item 182, wherein the syringe body defines the distal drug port. (Item 196) The system according to item 195, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 197) The system according to item 196, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 198) The system according to item 197, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 199) The system according to item 182, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 200) The system according to item 182, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 201) The system according to item 200, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 202) The system according to item 182, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 203) The system according to item 182, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 204) The system according to item 182, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 205) The system according to item 204, wherein the sealing coating comprises a PTFE film. (Item 206) The system according to item 182, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 207) The system according to item 206, wherein the lubricating layer contains silicone oil. (Item 208) The system according to item 182, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 209) The system according to item 208, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 210) The system according to item 182, wherein the needle comprises at least one radially protruding locking surface mechanism. (Item 211) The system according to item 210, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 212) The system according to item 211, wherein the through-element has a pointed tip. (Item 213) The system according to item 212, wherein the through element is a solid structure and does not have a lumen or aperture defined through it. (Item 214) The system according to item 211, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 215) The system according to item 210, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 216) The system according to item 215, wherein the cannula member and the hub member are formed from the same material piece. (Item 217) The system according to item 215, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 218) The system according to item 215, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 219) The system according to item 217, wherein the hub member is formed from a single piece of tubular material. (Item 220) The system according to item 215, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 221) The system according to item 218, wherein the cannula component includes metal. (Item 222) The system according to item 218, wherein the hub comprises a metal or plastic material. (Item 223) The aforementioned proximal member, made of metal or plastic material, is part of the system as described in item 218. (Item 224) The system according to item 182, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 225) The system according to item 224, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 226) The system according to item 225, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 227) The system according to item 226, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 228) The system according to item 227, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 229) The system according to item 224, wherein the energy storage member is a spring. (Item 230) The system according to item 229, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 231) The system according to item 229, wherein the spring comprises an elastomeric polymer. (Item 232) The system according to item 231, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 233) The system according to item 224, wherein the energy storage member includes a solid pellet member. (Item 234) The system according to item 233, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 235) The system according to item 229, wherein the spring comprises a single, generally helical coil. (Item 236) The system according to item 229, wherein the spring comprises a plurality of generally helical coils. (Item 237) The system according to item 236, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 238) The system according to item 236, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 239) The system described in item 237, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 240) The system according to item 238, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 241) The system according to item 224, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 242) The system according to item 182, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 243) The system according to item 182, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 244) The system according to item 182, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 245) The system according to item 244, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 246) The system according to item 244, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 247) The system according to item 226, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 248) The system according to item 182, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 249) The system according to item 248, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 250) The system according to item 249, wherein the braking member comprises a plate aperture braking section. (Item 251) The system according to item 250, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 252) The system according to item 250, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 253) The system according to item 252, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 254) The system according to item 249, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 255) The system according to item 254, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 256) The system according to item 254, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 257) The system according to item 255, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 258) The system according to item 256, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 259) The system according to item 248, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 260) The system according to item 259, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 261) The system according to item 182, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 262) The system according to item 261, wherein the needle covering member is detachably connected to the needle by at least one snap-over type locking joint. (Item 263) The system according to item 262, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 264) The system according to item 263, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 265) The system according to item 263, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 266) The system according to item 261, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 267) The system according to item 182, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 268) The system according to item 267, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 269) The system according to item 182, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 270) The system according to item 182, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 271) The system according to item 270, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 272) The system according to item 270, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 273) It is a system for injection, a. A syringe body defining the internal drug chamber, and a distal needle connector defining the Luer taper, b. A stopper member having a proximal end and a distal end, configured to be inserted into the internal drug chamber to house the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is connected to the distal needle joint of the syringe body, A system in which the proximal end of the needle is configured to be detachably connected to the outer surface of the lure taper. (Item 274) The system described in item 273, wherein the syringe body includes a commercially available syringe body. (Item 275) The system according to item 273, wherein the syringe body generally has a cylindrical geometric shape. (Item 276) The system according to item 273, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 277) The system according to item 276, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 278) The system according to item 273, wherein the syringe body includes a glass material. (Item 279) The system according to item 273, wherein the syringe body comprises a polymer material. (Item 280) The system according to item 279, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 281) The system according to item 273, wherein the syringe body contains metal. (Item 282) The system according to item 273, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 283) The system according to item 282, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 284) The system according to item 282, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 285) The system described in item 273, wherein the syringe body defines the distal drug port. (Item 286) The system according to item 285, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 287) The system according to item 286, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 288) The system according to item 287, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 289) The system according to item 273, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 290) The system according to item 273, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 291) The system according to item 290, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 292) The system according to item 273, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 293) The system according to item 273, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 294) The system according to item 273, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 295) The system according to item 294, wherein the sealing coating comprises a PTFE film. (Item 296) The system according to item 273, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 297) The system according to item 296, wherein the lubricating layer contains silicone oil. (Item 298) The system according to item 273, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 299) The system according to item 298, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 300) The system according to item 273, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 301) The system according to item 300, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 302) The system according to item 301, wherein the through-element has a pointed tip. (Item 303) The system according to item 302, wherein the through-element is a solid structure and does not have a lumen or aperture defined through it. (Item 304) The system according to item 301, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 305) The system according to item 300, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 306) The system according to item 305, wherein the cannula member and the hub member are formed from the same material piece. (Item 307) The system according to item 305, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 308) The system according to item 305, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 309) The system according to item 307, wherein the hub member is formed from a single piece of tubular material. (Item 310) The system according to item 305, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 311) The system according to item 308, wherein the cannula component includes metal. (Item 312) The system according to item 308, wherein the hub is made of metal or plastic material. (Item 313) The aforementioned proximal member, made of metal or plastic material, is part of the system described in item 308. (Item 314) The system according to item 273, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 315) The system according to item 314, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 316) The system according to item 315, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 317) The system according to item 316, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 318) The system according to item 317, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 319) The system according to item 314, wherein the energy storage member is a spring. (Item 320) The system according to item 319, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 321) The system according to item 319, wherein the spring comprises an elastomeric polymer. (Item 322) The system according to item 321, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 323) The system according to item 314, wherein the energy storage member includes a solid pellet member. (Item 324) The system according to item 323, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 325) The system according to item 319, wherein the spring comprises a single, generally helical coil. (Item 326) The system according to item 319, wherein the spring comprises a plurality of generally helical coils. (Item 327) The system according to item 326, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 328) The system according to item 326, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 329) The system described in item 327, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 330) The system according to item 329, wherein the helical coils, which are aligned coaxially and parallel to each other in the longitudinal direction, are wound helically in opposite winding directions to each other so as to prevent interference between the coils when the coils are compressed. (Item 331) The system according to item 316, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 332) The system according to item 273, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 333) The system according to item 273, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 334) The plunger member includes a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent reinsertion of the plunger member into the syringe body after the plunger member is first inserted into a predetermined position relative to the syringe body. The system according to item 273. (Item 335) The system according to item 334, wherein the predetermined position is a position where the stopper member has advanced to a position where it is fully inserted into the syringe body by the plunger member. (Item 336) The system according to item 334, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint portion engageable with a handle portion of the syringe body. (Item 337) The system according to item 314, further comprising a trigger engagement member configured to be connected to the syringe body and engage with a trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 338) The system according to item 273, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 339) The system according to item 338, further comprising a braking member operably connected to the plunger member and the syringe body, the braking member configured to facilitate insertion of the plunger member into the syringe body but resist storage of the plunger member in the syringe body in a first mode until the braking member is disposed in a second mode of a braking release configuration. (Item 340) [[ID=...]] The system according to item 339, wherein the braking member comprises a plate aperture braking portion. (Item 341) The system according to item 340, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 342) The system according to item 340, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 343) The system according to item 342, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 344) The system according to item 339, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 345) The system according to item 344, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 346) The system according to item 344, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 347) The system according to item 342, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 348) The system according to item 346, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 349) The system according to item 338, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 350) The system according to item 349, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 351) The system according to item 273, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 352) The system according to item 351, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 353) The system according to item 352, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 354) The system according to item 353, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 355) The system according to item 353, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 356) The system according to item 351, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 357) The system according to item 273, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 358) The system according to item 357, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 359) The system according to item 273, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 360) The system according to item 273, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 361) The system according to item 360, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 362) The system according to item 360, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 363) It is a system for injection, a. Syringe body defining the internal drug chamber, and distal needle connection, b. A stopper member configured to be inserted into the internal drug chamber to accommodate a drug in the drug chamber; c. A plunger member configured to be manually operated to insert the stopper member into the syringe body; d. A needle having a proximal end and a distal end, wherein the proximal end is configured to be connected to the stopper member when the stopper member is fully inserted into a storage position, so that when the stopper member is stored, the needle is pulled proximally together with the stopper and configured to be accommodated in the internal drug chamber; a needle, comprising: The system is configured such that when the needle is stored in the internal drug chamber at a position where the distal end of the needle is accommodated in the internal drug chamber, the needle is prevented from coming out of the internal drug chamber and being reinserted by becoming misaligned with the longitudinal axis of the syringe body. (Item 364) The system according to item 363, wherein the needle is configured to be plastically deformed when an attempt is made to reinsert the needle into the syringe body after the needle has become misaligned with the longitudinal axis of the syringe body. (Item 365) The system according to item 364, wherein the needle is configured to be plastically deformed with bending at at least a part of the needle. (Item 366) The system according to item 363, wherein the syringe body includes a commercially available syringe body. (Item 367) The system according to item 363, wherein the syringe body generally has a cylindrical geometry. (Item 368) The system according to item 363, wherein the drug chamber is configured to accommodate about 0.5 cc to about 5 cc of a drug. (Item 369) The system according to item 368, wherein the drug chamber is configured to accommodate a drug having a volume selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 370) The system according to item 363, wherein the syringe body includes a glass material. (Item 371) The system according to item 363, wherein the syringe body comprises a polymer material. (Item 372) The system according to item 371, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 373) The system according to item 363, wherein the syringe body contains metal. (Item 374) The system according to item 363, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 375) The system according to item 374, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 376) The system according to item 374, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 377) The system according to item 363, wherein the syringe body defines the distal drug port. (Item 378) The system according to item 377, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 379) The system according to item 378, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 380) The system according to item 379, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 381) The system according to item 363, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 382) The system according to item 363, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 383) The system according to item 382, ​​wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 384) The system according to item 363, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 385) The system according to item 363, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 386) The system according to item 363, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 387) The system according to item 386, wherein the sealing coating includes a PTFE film. (Item 388) The system according to item 363, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 389) The system according to item 388, wherein the lubricating layer contains silicone oil. (Item 390) The system according to item 363, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 391) The system according to item 390, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 392) The system according to item 363, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 393) The system according to item 392, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 394) The system according to item 393, wherein the through-element has a pointed tip. (Item 395) The system according to item 394, wherein the through element is a solid structure and does not have a lumen or aperture defined through it. (Item 396) The system according to item 393, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 397) The system according to item 392, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 398) The system according to item 397, wherein the cannula member and the hub member are formed from the same material piece. (Item 399) The system according to item 397, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 400) The system according to item 397, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 401) The system according to item 399, wherein the hub member is formed from a single piece of tubular material. (Item 402) The system according to item 397, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 403) The system according to item 400, wherein the cannula component includes metal. (Item 404) The system according to item 400, wherein the hub is made of metal or plastic material. (Item 405) The aforementioned proximal member, made of metal or plastic material, the system as described in item 400. (Item 406) The system according to item 363, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 407) The system according to item 406, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 408) The system according to item 407, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 409) The system according to item 408, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 410) The system according to item 409, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 411) The system according to item 406, wherein the energy storage member is a spring. (Item 412) The system according to item 411, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 413) The system according to item 411, wherein the spring comprises an elastomeric polymer. (Item 414) The system according to item 413, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 415) The system according to item 406, wherein the energy storage member includes a solid pellet member. (Item 416) The system according to item 415, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubber. (Item 417) The system according to item 411, wherein the spring comprises a single, generally helical coil. (Item 418) The system according to item 411, wherein the spring comprises a plurality of generally helical coils. (Item 419) The system according to item 418, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 420) The system according to item 418, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 421) The system described in item 419, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 422) The system according to item 421, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 423) The system according to item 406, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 424) The system according to item 363, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 425) The system according to item 363, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 426) The system according to item 363, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 427) The system according to item 426, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member is fully inserted into the syringe body. (Item 428) The system according to item 426, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 429) The system according to item 406, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 430) The system according to item 363, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 431) The system according to item 430, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 432) The system according to item 431, wherein the braking member comprises a plate aperture braking section. (Item 433) The system according to item 432, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 434) The system according to item 432, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 435) The system according to item 434, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 436) The system according to item 431, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 437) The system according to item 436, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 438) The system according to item 436, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 439) The system according to item 437, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 440) The system according to item 438, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 441) The system according to item 430, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 442) The system according to item 441, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 443) The system according to item 363, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 444) The system according to item 443, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 445) The system according to item 444, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 446) The system according to item 445, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 447) The system according to item 445, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 448) The system according to item 443, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 449) The system according to item 363, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 450) The system according to item 449, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 451) The system according to item 363, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 452) The system according to item 363, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 453) The system according to item 452, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 454) The system according to item 452, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 455) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a pointed distal end, e. A system comprising a needle door member, which is movably connected to the syringe body and is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 456) The system according to item 455, wherein the needle door member defines an aperture through which the needle passes, configured to facilitate the penetration of the needle when in the first state, and is configured in the second state such that the aperture does not align with the longitudinal axis of the needle, so that the needle does not penetrate the aperture, but is repositioned relative to the syringe body so that insertion of the needle is blocked by the non-aperture portion of the door member when an attempt is made to insert the needle into the needle door member. (Item 457) The system according to item 455, wherein the needle door member is configured to move slidably in a plane with respect to the longitudinal axis of the needle. (Item 458) The system according to item 457, wherein the needle door member is configured to move slidably in a plane substantially perpendicular to the longitudinal axis of the needle. (Item 459) The system according to item 455, wherein the needle door member is configured to rotate with respect to the longitudinal axis of the needle. (Item 460) The system according to item 459, wherein the needle door member is configured to rotate about an axis of rotation that substantially intersects the longitudinal axis of the needle. (Item 461) The system according to item 459, wherein the needle door member is configured to rotate about an axis of rotation that does not intersect the longitudinal axis of the needle. (Item 462) The system according to item 460, wherein the needle door member has a spherical geometric shape through which a needle penetration channel is defined. (Item 463) The system described in item 455, wherein the syringe body includes a commercially available syringe body. (Item 464) The system according to item 455, wherein the syringe body generally has a cylindrical geometric shape. (Item 465) The system according to item 455, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 466) The system according to item 465, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 467) The system according to item 455, wherein the syringe body includes a glass material. (Item 468) The system according to item 455, wherein the syringe body comprises a polymer material. (Item 469) The system according to item 468, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 470) The system described in item 455, wherein the syringe body contains metal. (Item 471) The system according to item 455, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 472) The system according to item 472, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 473) The system according to item 472, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 474) The system described in item 455, wherein the syringe body defines the distal drug port. (Item 475) The system according to item 474, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 476) The system according to item 475, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 477) The system according to item 475, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 478) The system according to item 455, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 479) The system according to item 455, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 480) The system according to item 479, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 481) The system according to item 455, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 482) The system according to item 455, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 483) The system according to item 455, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 484) The system according to item 483, wherein the sealing coating comprises a PTFE film. (Item 485) The system according to item 455, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 486) The system according to item 485, wherein the lubricating layer contains silicone oil. (Item 487) The system according to item 455, wherein the distal portion of the stopper member is equipped with a conventional commercially available compliant stopper. (Item 488) The system according to item 487, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 489) The system according to item 455, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 490) The system according to item 489, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 491) The system according to item 490, wherein the through-element has a pointed tip. (Item 492) The system according to item 491, wherein the through element is a solid structure and does not have a lumen or aperture defined through it. (Item 493) The system according to item 490, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 494) The system according to item 489, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 495) The system according to item 494, wherein the cannula member and the hub member are formed from the same material piece. (Item 496) The system according to item 494, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 497) The system according to item 494, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 498) The system according to item 496, wherein the hub member is formed from a single piece of tubular material. (Item 499) The system according to item 494, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (item 500) The system according to item 497, wherein the cannula component includes metal. (Item 501) The system according to item 497, wherein the hub comprises a metal or plastic material. (Item 502) The aforementioned proximal member, made of metal or plastic material, the system as described in item 497. (Item 503) The system according to item 455, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 504) The system according to item 503, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 505) The system according to item 504, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 506) The system according to item 505, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 507) The system according to item 506, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 508) The system according to item 503, wherein the energy storage member is a spring. (Item 509) The system according to item 508, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 510) The system according to item 508, wherein the spring comprises an elastomeric polymer. (Item 511) The system according to item 510, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 512) The system according to item 503, wherein the energy storage member includes a solid pellet member. (Item 513) The system according to item 512, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 514) The system according to item 508, wherein the spring includes a single, generally helical coil. (Item 515) The system according to item 508, wherein the spring comprises a plurality of generally helical coils. (Item 516) The system according to item 515, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 517) The system according to item 515, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 518) The system described in item 516, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 519) The system according to item 518, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 520) The system according to item 503, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 521) The system according to item 455, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 522) The system according to item 455, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 523) The system according to item 455, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 524) The system according to item 523, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 525) The system according to item 523, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 526) The system according to item 504, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 527) The system according to item 455, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 528) The system according to item 527, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 529) The system according to item 528, wherein the braking member comprises a plate aperture braking section. (Item 530) The system according to item 529, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 531) The system according to item 529, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 532) The system according to item 531, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 533) The system according to item 528, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 534) The system according to item 533, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 535) The system according to item 533, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 536) The system according to item 534, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 537) The system according to item 535, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 538) The system according to item 527, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 539) The system according to item 406, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 540) The system according to item 455, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 541) The system according to item 540, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 542) The system according to item 541, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 543) The system according to item 542, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 544) The system according to item 542, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 545) The system according to item 540, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 546) The system according to item 455, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 547) The system according to item 546, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 548) The system according to item 455, further comprising an extension member connected to the proximal end of the syringe body, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member comprising a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and which may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 549) The system according to item 455, wherein the plunger member is configured to be manually retracted by an operator to the second state. (Item 550) It is a system for injection, a. A syringe body defining the internal drug chamber, and a distal needle connector defining the Luer taper, b. A stopper member having a proximal end and a distal end, configured to be inserted into the internal drug chamber to house the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A drug cap, which is detachably connected to the distal needle joint and configured to seal the internal drug chamber, e. A needle having a proximal end and a distal end, wherein the proximal end comprises a connecting portion configured to be detachably connected to the outer surface of the Luer taper after the drug cap has been removed, and a retracting portion configured to be connected to the stopper member so that the needle can be retracted into the syringe body when the stopper member is retracted into the syringe body, (Item 551) The system described in item 550, wherein the syringe body includes a commercially available syringe body. (Item 552) The system according to item 550, wherein the syringe body generally has a cylindrical geometric shape. (Item 553) The system according to item 550, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 554) The system according to item 553, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 555) The system according to item 550, wherein the syringe body includes a glass material. (Item 556) The system according to item 550, wherein the syringe body comprises a polymer material. (Item 557) The system according to item 556, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 558) The system described in item 550, wherein the syringe body contains metal. (Item 559) The system according to item 550, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 560) The system according to item 559, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 561) The system according to item 559, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 562) The system described in item 550, wherein the syringe body defines the distal drug port. (Item 563) The system according to item 562, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 564) The system according to item 563, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 565) The system according to item 564, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 566) The system according to item 550, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 567) The system according to item 550, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 568) The system according to item 567, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 569) The system according to item 550, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 570) The system according to item 550, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 571) The system according to item 550, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 572) The system according to item 571, wherein the encapsulant coating includes a PTFE film. (Item 573) The system according to item 550, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 574) The system according to item 573, wherein the lubricating layer contains silicone oil. (Item 575) The system according to item 550, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 576) The system according to item 575, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 577) The system according to item 550, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 578) The system according to item 577, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 579) The system according to item 578, wherein the through-element has a pointed tip. (Item 580) The system according to item 579, wherein the through element is a solid structure and has no lumen or aperture defined through it. (Item 581) The system according to item 578, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 582) The system according to item 577, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 583) The system according to item 582, wherein the cannula member and the hub member are formed from the same material piece. (Item 584) The system according to item 582, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 585) The system according to item 582, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 586) The system according to item 584, wherein the hub member is formed from a single piece of tubular material. (Item 587) The system according to item 584, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 588) The system according to item 585, wherein the cannula component includes metal. (Item 589) The system according to item 585, wherein the hub comprises a metal or plastic material. (Item 590) The aforementioned proximal member, made of metal or plastic material, the system as described in item 585. (Item 591) The system according to item 550, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 592) The system according to item 591, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 593) The system according to item 592, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 594) The system according to item 593, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 595) The system according to item 594, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 596) The system according to item 591, wherein the energy storage member is a spring. (Item 597) The system according to item 596, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 598) The system according to item 596, wherein the spring comprises an elastomeric polymer. (Item 599) The system according to item 598, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (item 600) The system according to item 591, wherein the energy storage member includes a solid pellet member. (Item 601) The system according to item 600, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 602) The system according to item 596, wherein the spring comprises a single, generally helical coil. (Item 603) The system according to item 596, wherein the spring comprises a plurality of generally helical coils. (Item 604) The system according to item 603, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 605) The system according to item 603, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 606) The system described in item 604, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 607) The system according to item 606, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 608) The system according to item 591, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 609) The system according to item 550, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 610) The system according to item 550, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 611) The system according to item 550, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 612) The system according to item 611, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 613) The system according to item 611, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 614) The system according to item 593, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 615) The system according to item 550, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 616) The system according to item 615, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 617) The system according to item 616, wherein the braking member comprises a plate aperture braking section. (Item 618) The system according to item 617, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 619) The system according to item 617, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 620) The system according to item 619, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 621) The system according to item 616, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 622) The system according to item 621, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 623) The system according to item 621, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 624) The system according to item 622, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 625) The system according to item 623, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 626) The system according to item 615, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 627) The system according to item 626, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 628) The system according to item 550, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 629) The system according to item 628, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 630) The system according to item 629, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 631) The system according to item 630, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 632) The system according to item 630, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 633) The system according to item 628, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly radiating protruding surfaces. (Item 634) The system according to item 550, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 635) The system according to item 634, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 636) The system according to item 550, further comprising an extension member connected to the proximal end of the syringe body, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member having a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and which may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 637) The system according to item 550, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 638) The system according to item 637, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 639) The system according to item 637, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 640) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a pointed proximal end and a pointed distal end, e. A system comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and at the same time to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 641) The system described in item 640, wherein the syringe body includes a commercially available syringe body. (Item 642) The system according to item 640, wherein the syringe body generally has a cylindrical geometric shape. (Item 643) The system according to item 640, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 644) The system according to item 643, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 645) The system according to item 640, wherein the syringe body includes a glass material. (Item 646) The system according to item 640, wherein the syringe body comprises a polymer material. (Item 647) The system according to item 646, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 648) The system described in item 640, wherein the syringe body contains metal. (Item 649) The system according to item 640, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 650) The system according to item 649, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 651) The system according to item 649, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 652) The system described in item 640, wherein the syringe body defines the distal drug port. (Item 653) The system according to item 652, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 654) The system according to item 653, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 655) The system according to item 654, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 656) The system according to item 640, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 657) The system according to item 640, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 658) The system according to item 657, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 659) The system according to item 640, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 660) The system according to item 640, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 661) The system according to item 640, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 662) The system according to item 661, wherein the sealing coating includes a PTFE film. (Item 663) The system according to item 640, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 664) The system according to item 663, wherein the lubricating layer contains silicone oil. (Item 665) The system according to item 640, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 666) The system according to item 665, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 667) The system according to item 640, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 668) The system according to item 667, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 669) The system according to item 668, wherein the through-element has a pointed tip. (Item 670) The system according to item 669, wherein the through element is a solid structure and does not have a lumen or aperture defined through it. (Item 671) The system according to item 668, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 672) The system according to item 667, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 673) The system according to item 672, wherein the cannula member and the hub member are formed from the same material piece. (Item 674) The system according to item 672, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 675) The system according to item 672, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 676) The system according to item 674, wherein the hub member is formed from a single piece of tubular material. (Item 677) The system according to item 672, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 678) The system according to item 676, wherein the cannula component includes metal. (Item 679) The system according to item 676, wherein the hub comprises a metal or plastic material. (Item 680) The aforementioned proximal member, made of metal or plastic material, the system as described in item 676. (Item 681) The system according to item 640, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 682) The system according to item 681, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 683) The system according to item 682, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member has a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 684) The system according to item 683, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 685) The system according to item 684, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 686) The system according to item 681, wherein the energy storage member is a spring. (Item 687) The system according to item 686, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 688) The system according to item 686, wherein the spring comprises an elastomeric polymer. (Item 689) The system according to item 686, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 690) The system according to item 681, wherein the energy storage member includes a solid pellet member. (Item 691) The system according to item 690, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 692) The system according to item 686, wherein the spring comprises a single, generally helical coil. (Item 693) The system according to item 686, wherein the spring comprises a plurality of generally helical coils. (Item 694) The system according to item 693, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 695) The system according to item 693, wherein at least two of the coils, which include a plurality of generally spiral coils, are aligned parallel to each other in the longitudinal direction. (Item 696) The system described in item 694, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 697) The system according to item 696, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 698) The system according to item 681, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 699) The system according to item 640, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 700) The system according to item 640, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 701) The system according to item 640, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 702) The system according to item 701, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 703) The system according to item 701, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 704) The system according to item 683, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 705) The system according to item 640, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 706) The system according to item 705, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 707) The system according to item 706, wherein the braking member comprises a plate aperture braking section. (Item 708) The system according to item 707, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 709) The system according to item 707, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 710) The system according to item 709, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 711) The system according to item 706, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 712) The system according to item 711, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 713) The system according to item 711, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 714) The system according to item 712, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 715) The system according to item 713, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 716) The system according to item 705, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 717) The system according to item 716, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 718) The system according to item 640, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 719) The system according to item 718, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 720) The system according to item 719, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 721) The system according to item 719, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 722) The system according to item 640, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly radiating protruding surfaces. (Item 723) The system according to item 640, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 724) The system according to item 723, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 725) The system according to item 640, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 726) The system according to item 640, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 727) The system according to item 726, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 728) The system according to item 726, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 729) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a pointed proximal end and a pointed distal end, e. A system further comprising: a needle covering member defining an internal volume configured to temporarily house and protect at least the pointed distal end of the needle, and detachably connectable to the needle by at least one snap-over locking joint. (Item 730) The system described in item 729, wherein the syringe body includes a commercially available syringe body. (Item 731) The system according to item 729, wherein the syringe body generally has a cylindrical geometric shape. (Item 732) The system according to item 729, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 733) The system according to item 732, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 734) The system according to item 729, wherein the syringe body includes a glass material. (Item 735) The system according to item 729, wherein the syringe body comprises a polymer material. (Item 736) The system according to item 735, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 737) The system described in item 729, wherein the syringe body contains metal. (Item 738) The system according to item 729, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 739) The system according to item 738, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 740) The system according to item 738, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 741) The system described in item 729, wherein the syringe body defines the distal drug port. (Item 742) The system according to item 741, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 743) The system according to item 742, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 744) The system according to item 743, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 745) The system according to item 729, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 746) The system according to item 729, further comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 747) The system according to item 746, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 748) The system according to item 729, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 749) The system according to item 729, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 750) The system according to item 729, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 751) The system according to item 750, wherein the sealing coating includes a PTFE film. (Item 752) The system according to item 729, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 753) The system according to item 752, wherein the lubricating layer contains silicone oil. (Item 754) The system according to item 729, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 755) The system according to item 754, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 756) The system according to item 729, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 757) The system according to item 756, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 758) The system according to item 757, wherein the through-element has a pointed tip. (Item 759) The system according to item 758, wherein the through-element is a solid structure and has no lumen or aperture defined through it. (Item 760) The system according to item 757, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 761) The system according to item 756, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 762) The system according to item 761, wherein the cannula member and the hub member are formed from the same material piece. (Item 763) The system according to item 761, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 764) The system according to item 761, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 765) The system according to item 763, wherein the hub member is formed from a single piece of tubular material. (Item 766) The system according to item 761, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 767) The system according to item 764, wherein the cannula component includes metal. (Item 768) The system according to item 764, wherein the hub comprises a metal or plastic material. (Item 769) The aforementioned proximal member, made of metal or plastic material, the system as described in item 764. (Item 770) The system according to item 729, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 771) The system according to item 770, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 772) The system according to item 771, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 773) The system according to item 772, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 774) The system according to item 773, wherein the predetermined insertion position is the position in which the stopper is positioned in a fully inserted state relative to the syringe body. (Item 775) The system according to item 770, wherein the energy storage member is a spring. (Item 776) The system according to item 775, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 777) The system according to item 775, wherein the spring comprises an elastomeric polymer. (Item 778) The system according to item 770, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 779) The system according to item 770, wherein the energy storage member includes a solid pellet member. (Item 780) The system according to item 779, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 781) The system according to item 775, wherein the spring comprises a single, generally helical coil. (Item 782) The system according to item 775, wherein the spring comprises a plurality of generally helical coils. (Item 783) The system according to item 782, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 784) The system according to item 782, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 785) The system described in item 516, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 786) The system according to item 785, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when they are compressed. (Item 787) The system according to item 770, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 788) The system according to item 729, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 789) The system according to item 729, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 790) The system according to item 729, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 791) The system according to item 790, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 792) The system according to item 790, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 793) The system according to item 772, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 794) The system according to item 729, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 795) The system according to item 794, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 796) The system according to item 795, wherein the braking member comprises a plate aperture braking section. (Item 797) The system according to item 796, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 798) The system according to item 796, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 799) The system according to item 798, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (item 800) The system according to item 795, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 801) The system according to item 800, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 802) The system according to item 800, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 803) The system according to item 801, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 804) The system according to item 802, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 805) The system according to item 794, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 806) The system according to item 805, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 807) The system according to item 729, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 808) The system according to item 729, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 809) The system according to item 808, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 810) The system according to item 808, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 811) The system according to item 807, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 812) The system according to item 729, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 813) The system according to item 812, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 814) The system according to item 729, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 815) The system according to item 729, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 816) The system according to item 815, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 817) The system according to item 815, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 818) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, and a bubble discharge lumen defined between them, wherein the bubble discharge lumen is defined into the needle and includes an inlet port located directly adjacent to the distal end of the drug chamber, so that bubbles in the drug chamber can be discharged by insertion of the stopper member, regardless of the degree to which the proximal end of the needle protrudes into the drug chamber. (Item 819) The system described in item 818, wherein the syringe body includes a commercially available syringe body. (Item 820) The system according to item 818, wherein the syringe body generally has a cylindrical geometric shape. (Item 821) The system according to item 818, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 822) The system according to item 821, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 823) The system according to item 818, wherein the syringe body includes a glass material. (Item 824) The system according to item 818, wherein the syringe body comprises a polymer material. (Item 825) The system according to item 824, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 826) The system described in item 818, wherein the syringe body contains metal. (Item 827) The system according to item 818, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 828) The system according to item 827, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 829) The system according to item 827, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 830) The system according to item 818, wherein the syringe body defines the distal drug port. (Item 831) The system according to item 830, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 832) The system according to item 831, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 833) The system according to item 832, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 834) The system according to item 818, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 835) The system according to item 818, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 836) The system according to item 835, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 837) The system according to item 818, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 838) The system according to item 818, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 839) The system according to item 818, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 840) The system according to item 839, wherein the sealing coating comprises a PTFE film. (Item 841) The system according to item 818, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 842) The system according to item 841, wherein the lubricating layer contains silicone oil. (Item 843) The system according to item 818, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 844) The system according to item 843, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 845) The system according to item 818, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 846) The system according to item 845, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 847) The system according to item 846, wherein the through-element has a pointed tip. (Item 848) The system according to item 847, wherein the through element is a solid structure and has no lumen or aperture defined through it. (Item 849) The system according to item 846, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 850) The system according to item 845, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 851) The system according to item 850, wherein the cannula member and the hub member are formed from the same material piece. (Item 852) The system according to item 850, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 853) The system according to item 850, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 854) The system according to item 852, wherein the hub member is formed from a single piece of tubular material. (Item 855) The system according to item 850, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 856) The system according to item 853, wherein the cannula component includes metal. (Item 857) The system according to item 853, wherein the hub is made of metal or plastic material. (Item 858) The aforementioned proximal member, made of metal or plastic material, the system as described in item 853. (Item 859) The system according to item 818, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 860) The system according to item 859, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 861) The system according to item 860, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 862) The system according to item 861, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 863) The system according to item 862, wherein the predetermined insertion position is the position in which the stopper is positioned in a fully inserted state relative to the syringe body. (Item 864) The system according to item 859, wherein the energy storage member is a spring. (Item 865) The system according to item 864, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 866) The system according to item 864, wherein the spring comprises an elastomeric polymer. (Item 867) The system according to item 866, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 868) The system according to item 859, wherein the energy storage member includes a solid pellet member. (Item 869) The system according to item 868, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 870) The system according to item 864, wherein the spring comprises a single, generally helical coil. (Item 871) The system according to item 864, wherein the spring comprises a plurality of generally helical coils. (Item 872) The system according to item 871, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 873) The system according to item 871, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 874) The system described in item 872, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 875) The system according to item 874, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when the coils are compressed. (Item 876) The system according to item 859, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 877) The system according to item 818, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 878) The system according to item 818, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 879) The system according to item 818, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 880) The system according to item 879, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 881) The system according to item 879, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 882) The system according to item 861, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 883) The system according to item 818, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 884) The system according to item 883, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 885) The system according to item 884, wherein the braking member comprises a plate aperture braking section. (Item 886) The system according to item 885, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 887) The system according to item 885, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 888) The system according to item 887, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 889) The system according to item 884, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 890) The system according to item 889, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 891) The system according to item 889, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 892) The system according to item 890, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 893) The system according to item 891, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 894) The system according to item 883, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 895) The system according to item 894, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 896) The system according to item 818, further comprising a needle covering member that defines an internal volume, which is configured to temporarily house and protect at least the pointed distal end of the needle, and to align the pointed proximal end of the needle for connection with the syringe body when installed by the user. (Item 897) The system according to item 896, wherein the needle covering member is detachably connected to the needle by at least one snap-over locking joint. (Item 898) The system according to item 897, wherein the needle covering member is detachably connected to the needle by at least two snap-over locking joints. (Item 899) The system according to item 898, wherein the snap-over locking joint is oriented to prevent rotation of the needle covering member about an axis substantially aligned with the axis of the needle until the locking joint is mechanically overcome by a torsional load. (Item 900) The system according to item 898, wherein the snap-over locking joint is oriented to prevent axial movement of the needle covering member relative to the needle until the locking mechanism is mechanically overcome by an axial load. (Item 901) The system according to item 896, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected, and comprises a plurality of inwardly facing radial projections. (Item 902) The system according to item 818, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 903) The system according to item 902, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 904) The system according to item 818, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 905) The system according to item 818, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 906) The system according to item 905, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 907) The system according to item 905, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 908) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a pointed proximal end and a pointed distal end, e. A distal sealing element having a proximal end and a distal end, which is sealably disposed within the drug chamber, wherein the distal sealing element is releasably connected to the proximal end of the needle so that a sealed joint is provided between them, In the first coupling mode, the pointed proximal end of the needle is positioned at least partially through the distal sealing element such that the distal sealing element grips the proximal end of the needle. A system in which, in a second release mode, an expansion element expands the junction between the distal sealing element and the pointed end of the needle so that the needle can be released from the distal sealing element. (Item 909) The system according to item 908, wherein the pointed proximal end of the needle is connected to the stopper member such that when the stopper member is retracted, the needle is pulled proximal together with the stopper and is at least partially housed within the internal drug chamber. (Item 910) The system according to item 909, comprising an anchor geometry configured such that the pointed proximal end of the needle is at least partially inserted into the stopper member. (Item 911) The system described in item 908, wherein the syringe body includes a commercially available syringe body. (Item 912) The system according to item 908, wherein the syringe body generally has a cylindrical geometric shape. (Item 913) The system according to item 908, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 914) The system according to item 913, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 915) The system according to item 908, wherein the syringe body includes a glass material. (Item 916) The system according to item 908, wherein the syringe body comprises a polymer material. (Item 917) The system according to item 916, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 918) The system according to item 918, wherein the syringe body contains metal. (Item 919) The system according to item 908, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 920) The system according to item 919, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 921) The system according to item 919, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 922) The system according to item 908, wherein the syringe body defines the distal drug port. (Item 923) The system according to item 922, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 924) The system according to item 923, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 925) The system according to item 924, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 926) The system according to item 908, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 927) The system according to item 908, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 928) The system according to item 927, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member which is insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 929) The system according to item 908, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 930) The system according to item 908, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 931) The system according to item 908, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 932) The system according to item 931, wherein the sealing coating includes a PTFE film. (Item 933) The system according to item 908, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 934) The system according to item 933, wherein the lubricating layer contains silicone oil. (Item 935) The system according to item 908, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 936) The system according to item 935, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 937) The system according to item 908, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 938) The system according to item 937, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 939) The system according to item 938, wherein the through-element has a pointed tip. (Item 940) The system according to item 938, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 941) The system according to item 937, wherein the needle comprises a cannula member and a hub member. (Item 942) The system according to item 941, wherein the cannula member and the hub member are formed from the same material piece. (Item 943) The system according to item 941, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 944) The system according to item 941, wherein the cannula member protrudes axially at a location proximal to the hub member and forms a sealing surface configured to bond with the distal sealing element. (Item 945) The system according to item 943, wherein the hub member is formed from a single piece of tubular material. (Item 946) The system according to item 944, wherein the cannula component includes metal. (Item 947) The system according to item 944, wherein the hub comprises a metal or plastic material. (Item 948) The system according to item 908, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 949) The system according to item 948, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 950) The system according to item 949, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 951) The system according to item 950, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 952) The system according to item 951, wherein the predetermined insertion position is the position in which the stopper is fully inserted relative to the syringe body. (Item 953) The system according to item 949, wherein the energy storage member is a spring. (Item 954) The system according to item 953, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 955) The system according to item 953, wherein the spring comprises an elastomeric polymer. (Item 956) The system according to item 955, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 957) The system according to item 948, wherein the energy storage member includes a solid pellet member. (Item 958) The system according to item 957, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 959) The system according to item 953, wherein the spring comprises a single, generally helical coil. (Item 960) The system according to item 953, wherein the spring comprises a plurality of generally helical coils. (Item 961) The system according to item 960, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 962) The system according to item 960, wherein at least two of the coils, which include a plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 963) The system described in item 961, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 964) The system according to item 963, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when the coils are compressed. (Item 965) The system according to item 948, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 966) The system according to item 908, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 967) The system according to item 908, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 968) The system according to item 908, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 969) The system according to item 968, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 970) The system according to item 968, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 971) The system according to item 950, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 972) The system according to item 908, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 973) The system according to item 972, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 974) The system according to item 973, wherein the braking member comprises a plate aperture braking section. (Item 975) The system according to item 974, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 976) The system according to item 974, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 977) The system according to item 976, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 978) The system according to item 973, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 979) The system according to item 978, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 980) The system according to item 978, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 981) The system according to item 979, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 982) The system according to item 980, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 983) The system according to item 972, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 984) The system according to item 983, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 985) The system according to item 908, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 986) The system according to item 985, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 987) The system according to item 908, further comprising an extension member connected to the proximal end of the syringe body, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member having a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and remaining connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 988) The system according to item 908, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 989) The system according to item 988, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 990) The system according to item 988, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 991) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a pointed proximal end and a pointed distal end, e. A distal sealing element detachably connected around at least a portion of the proximal end of the needle and configured to grip the proximal end of the needle until it expands away from it, f. An expansion element, which is connected to the proximal end of the needle and expands the distal sealing element away from the proximal end of the needle, thereby freeing the needle from the distal sealing element by the advance of the distal sealing element toward the expansion element, while the expansion element and the interconnected needle remain substantially immobile with respect to the syringe body. (Item 992) The system according to item 991, wherein the pointed proximal end of the needle is connected to the stopper member such that when the stopper member is retracted, the needle is pulled proximal together with the stopper and is at least partially housed within the internal drug chamber. (Item 993) The system according to item 992, comprising an anchor geometry configured such that the pointed proximal end of the needle is at least partially inserted into the stopper member. (Item 994) The system described in item 991, wherein the syringe body includes a commercially available syringe body. (Item 995) The system according to item 991, wherein the syringe body generally has a cylindrical geometric shape. (Item 996) The system according to item 991, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 997) The system according to item 996, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 998) The system according to item 991, wherein the syringe body includes a glass material. (Item 999) The system according to item 991, wherein the syringe body comprises a polymer material. (item 1000) The system according to item 999, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1001) The system according to item 991, wherein the syringe body contains metal. (Item 1002) The system according to item 991, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 1003) The system according to item 1002, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 1004) The system according to item 1002, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 1005) The system according to item 991, wherein the syringe body defines the distal drug port. (Item 1006) The system according to item 1005, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 1007) The system according to item 1006, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1008) The system according to item 1007, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 1009) The system according to item 991, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 1010) The system according to item 991, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 1011) The system according to item 1010, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 1012) The system according to item 991, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 1013) The system according to item 991, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1014) The system according to item 991, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 1015) The system according to item 1014, wherein the sealing coating includes a PTFE film. (Item 1016) The system according to item 991, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1017) The system according to item 1016, wherein the lubricating layer contains silicone oil. (Item 1018) The system according to item 991, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 1019) The system according to item 1018, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 1020) The system according to item 991, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 1021) The system according to item 1020, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 1022) The system according to item 1021, wherein the through-element has a pointed tip. (Item 1023) The system according to item 1021, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 1024) The system according to item 1020, wherein the needle comprises a cannula member and a hub member. (Item 1025) The system according to item 1024, wherein the cannula member and the hub member are formed from the same material piece. (Item 1026) The system according to item 1024, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 1027) The system according to item 1024, wherein the cannula member protrudes axially at a location proximal to the hub member and forms a sealing surface configured to bond with the distal sealing element. [The sealing portion seals the needle rather than the hub, whereas in the prior art the sealing portion seals the hub.] (Item 1028) The system according to item 1025, wherein the hub member is formed from a single piece of tubular material. (Item 1029) The system according to item 1027, wherein the cannula component includes metal. (Item 1030) The system according to item 1027, wherein the hub comprises a metal or plastic material. (Item 1031) The system according to item 991, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 1032) The system according to item 1031, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 1033) The system according to item 1032, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member is configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member in relation to the syringe body. (Item 1034) The system according to item 1033, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 1035) The system according to item 1034, wherein the predetermined insertion position is the position in which the stopper is positioned in a fully inserted state relative to the syringe body. (Item 1036) The system according to item 1031, wherein the energy storage member is a spring. (Item 1037) The system according to item 1036, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 1038) The system according to item 1036, wherein the spring comprises an elastomeric polymer. (Item 1039) The system according to item 1038, wherein the elastomeric polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 1040) The system according to item 1031, wherein the energy storage member includes a solid pellet member. (Item 1041) The system according to item 1040, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 1042) The system according to item 1036, wherein the spring comprises a single, generally helical coil. (Item 1043) The system according to item 1036, wherein the spring comprises a plurality of generally helical coils. (Item 1044) The system according to item 1043, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 1045) The system according to item 1043, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 1046) The system described in item 1045, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 1047) The system according to item 1046, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to prevent interference between the coils when the coils are compressed. (Item 1048) The system according to item 1031, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 1049) The system according to item 991, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 1050) The system according to item 991, further comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 1051) The system according to item 991, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, and the ratchet mechanisms are configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 1052) The system according to item 1051, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 1053) The system according to item 1051, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 1054) The system according to item 1033, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 1055) The system according to item 991, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 1056) The system according to item 1055, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 1057) The system according to item 1056, wherein the braking member comprises a plate aperture braking section. (Item 1058) The system according to item 1057, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 1059) The system according to item 1057, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 1060) The system according to item 1059, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 1061) The system according to item 1056, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 1062) The system according to item 1061, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 1063) The system according to item 1061, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 1064) The system according to item 1062, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 1065) The system according to item 1063, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 1066) The system according to item 1056, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 1067) The system according to item 1066, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 1068) The system according to item 991, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 1069) The system according to item 1068, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 1070) The system according to item 991, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, and the extension member comprises a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of drug, and may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface. (Item 1071) The system according to item 991, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1072) 104. The system according to item 1071, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 1073) The system according to item 1071, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the system is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body. (Item 1074) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is connected to the distal end of the syringe body, e. A needle sheath operably connected to the syringe body and defining a lumen through which at least the distal end of the needle can pass, wherein the needle sheath is configured to have a first state in which the needle sheath is compressed toward the proximal end of the needle to expose the distal end of the needle for injection, and a second state in which the needle sheath advances forward beyond the distal end of the needle to substantially cover the needle and prevent contact with the distal end of the needle, In the first state, if there is no sheath holding element to hold the needle sheath in the first position until the stopper member advances to a predetermined position relative to the syringe body, the energy storage member is compressed to bias the needle sheath and propel it forward to the second state. (Item 1075) The system according to item 1074, wherein the predetermined position of the stopper member is the position in which the stopper member has advanced to its maximum forward position relative to the syringe body. (Item 1076) The system according to item 1074, further comprising a sheath limiting member configured to prevent the needle sheath from advancing beyond a predetermined axial extension position relative to the syringe body to a second state. (Item 1077) The system according to item 1074, wherein the energy storage member comprises a spring. (Item 1078) The system according to item 1074, wherein at the predetermined position, the plunger applies a load to the needle that releases the sheath retaining element. (Item 1079) The system described in item 1074, wherein the syringe body includes a commercially available syringe body. (Item 1080) The system according to item 1074, wherein the syringe body generally has a cylindrical geometric shape. (Item 1081) The system according to item 1074, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 1082) The system according to item 1081, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 1083) The system according to item 1074, wherein the syringe body includes a glass material. (Item 1084) The system according to item 1074, wherein the syringe body comprises a polymer material. (Item 1085) The system according to item 11, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1086) The system described in item 1074, wherein the syringe body contains metal. (Item 1087) The system according to item 1074, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 1088) The system according to item 1087, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 1089) The system according to item 1087, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 1090) The system according to item 1074, wherein the syringe body defines the distal drug port. (Item 1091) The system according to item 1090, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 1092) The system according to item 1091, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1093) The system according to item 1092, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 1094) The system according to item 1074, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 1095) The system according to item 1074, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1096) The system according to item 1074, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 1097) The system according to item 1096, wherein the sealing coating comprises a PTFE film. (Item 1098) The system according to item 1074, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1099) The system according to item 1098, wherein the lubricating layer contains silicone oil. (Item 1100) The system according to item 1074, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 1101) The system according to item 1074, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 1102) The system according to item 1074, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 1103) The system according to item 1074, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 1104) The system according to item 1074, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 1105) The system according to item 1104, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 1106) The syringe body further comprises an extension member connected to its proximal end, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member comprising a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of the drug, and the extension member may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface, item 1 The system described in 074. (Item 1107) The system according to item 1074, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1108) The system according to item 1107, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 1109) The distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the device is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body, item 110 The system described in 7. (Item 1110) It is a system for injection, a. Syringe body defining the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is connected to the distal end of the syringe body, e. A retractable needle sheath operably connected to the syringe body and defining a lumen through which at least the distal end of the needle can pass, wherein the needle sheath is configured to have a first state in which the retractable needle sheath is retractably compressed toward the proximal end of the needle to expose the distal end of the needle for injection, and a second state in which the needle sheath is retractably advanced forward beyond the distal end of the needle to substantially cover the needle and prevent contact with the distal end of the needle, In the first state, if there is no sheath holding element to hold the needle sheath in the first position until the stopper member advances to a predetermined position relative to the syringe body, the energy storage member is compressed to bias the needle sheath and propel it forward to the second state, the system (Item 1111) The system according to item 1110, wherein the predetermined position of the stopper member is the position in which the stopper member has advanced to its maximum forward position relative to the syringe body. (Item 1112) The system according to item 1110, further comprising a sheath limiting member configured to prevent the needle sheath from advancing beyond a predetermined axial extension position relative to the syringe body to a second state. (Item 1113) The system according to item 1110, wherein the energy storage member comprises a spring. (Item 1114) The system according to item 1110, wherein at the predetermined position, the plunger applies a load to the needle that releases the sheath retaining element. (Item 1115) The system described in item 1110, wherein the syringe body includes a commercially available syringe body. (Item 1116) The system according to Item 1110, wherein the syringe body has a generally cylindrical geometric shape. (Item 1117) The system according to item 1110, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 1118) The system according to item 1117, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 1119) The system according to item 1110, wherein the syringe body includes a glass material. (Item 1120) The system according to item 1110, wherein the syringe body comprises a polymer material. (Item 1121) The system according to item 1120, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1122) The system described in item 1110, wherein the syringe body contains metal. (Item 1123) The system according to item 1110, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 1124) The system according to item 1123, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 1125) The system according to item 1123, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 1126) The system according to item 1110, wherein the syringe body defines the distal drug port. (Item 1127) The system according to item 1126, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 1128) The system according to item 1127, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1129) The system according to item 1128, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 1130) The system according to item 1110, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 1131) The system according to item 1110, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1132) The system according to item 1110, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 1133) The system according to item 1132, wherein the encapsulant coating includes a PTFE film. (Item 1134) The system according to item 1110, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1135) The system according to item 1134, wherein the lubricating layer contains silicone oil. (Item 1136) The system according to item 1110, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 1137) The system according to item 1110, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 1138) The system according to item 1110, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 1139) The system according to item 1110, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 1140) The system according to item 1110, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 1141) The system according to item 1140, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 1142) The syringe body further comprises an extension member connected to its proximal end, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member comprising a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of the drug, and the extension member may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface, item 1 The system described in 110. (Item 1143) The system according to item 1110, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1144) The system according to item 1143, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 1145) The distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the device is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body, item 114 The system described in section 3. (Item 1146) A system for injection, a. A syringe body defining an internal drug chamber, and a distal joint having a Luer taper that defines an internal surface fluidly connected to the internal drug chamber, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A system comprising a needle having a proximal end and a distal end, wherein the proximal end is detachably attached to the inner surface of the Luer taper. (Item 1147) The system described in item 1146, wherein the syringe body includes a commercially available syringe body. (Item 1148) The system according to item 1146, wherein the syringe body generally has a cylindrical geometric shape. (Item 1149) The system according to item 1146, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 1150) The system according to item 1150, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 1151) The system according to item 1146, wherein the syringe body includes a glass material. (Item 1152) The system according to item 1146, wherein the syringe body comprises a polymer material. (Item 1153) The system according to item 1152, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1154) The system according to item 1146, wherein the syringe body contains metal. (Item 1155) The system according to item 1146, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 1156) The system according to item 1155, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 1157) The system according to item 1155, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 1158) The system according to item 1146, wherein the syringe body defines the distal drug port. (Item 1159) The system according to item 1158, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 1160) The system according to item 1159, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1161) The system according to item 1160, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 1162) The system according to Item 1146, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 1163) The system according to item 1146, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 1164) The system according to item 1163, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 1165) The system according to item 1146, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 1166) The system according to item 1146, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1167) The system according to item 1146, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 1168) The system according to item 1167, wherein the sealing coating comprises a PTFE film. (Item 1169) The system according to item 1146, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1170) The system according to item 1169, wherein the lubricating layer contains silicone oil. (Item 1171) The system according to item 1146, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 1172) The system according to item 1171, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 1173) The system according to item 1146, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 1174) The system according to item 1173, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 1175) The system according to item 1174, wherein the through-element has a pointed tip. (Item 1176) The system according to item 1175, wherein the through-element is a solid structure and has no lumen or aperture defined through it. (Item 1177) The system according to item 1174, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 1178) The system according to item 1173, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 1179) The system according to item 1178, wherein the cannula member and the hub member are formed from the same material piece. (Item 1180) The system according to item 1178, wherein the cannula member and the hub member comprise separately formed elements that are fixed and connected together to form a part of the needle. (Item 1181) The system according to item 1178, wherein the proximal member also comprises separately formed elements that are fixed and connected to the cannula member and the hub member to form a part of the needle. (Item 1182) The system according to item 1180, wherein the hub member is formed from a single piece of tubular material. (Item 1183) The system according to item 1178, wherein the proximal member includes a flat sheet metal piece having a proximal connecting joint. (Item 1184) The system according to item 1181, wherein the cannula component includes metal. (Item 1185) The system according to item 1181, wherein the hub comprises a metal or plastic material. (Item 1186) The aforementioned proximal member, made of metal or plastic material, the system as described in item 1181. (Item 1187) The system according to item 1146, further comprising an energy storage member operably connected between the stopper member and the syringe body, wherein the energy storage member is configured to facilitate the retraction of the stopper member into the syringe body. (Item 1188) The system according to claim 1187, wherein the plunger member comprises a plunger member body that defines an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 1189) The system according to item 1188, further comprising a locking member operably connected to the plunger member and substantially housed within the internal volume of the plunger member body, wherein the locking member has a first mechanical state in which the locking member maintains the energy storage member in an energy storage state, and a second mechanical state in which the locking member causes the energy storage member to release the energy stored by the energy storage member, thereby assisting in the storage of the stopper member relative to the syringe body. (Item 1190) The system according to item 1189, wherein the locking member comprises a trigger portion, the trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body, so that the energy storage member can be automatically released when the plunger member and the interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 1191) The system according to item 1190, wherein the predetermined insertion position is the position in which the stopper is positioned in a fully inserted state relative to the syringe body. (Item 1192) The system according to item 1187, wherein the energy storage member is a spring. (Item 1193) The system according to Item 1192, wherein the spring is made of a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 1194) The system according to item 1192, wherein the spring comprises an elastomeric polymer. (Item 1195) The system according to claim 1194, wherein the elastomer polymer is selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, and rubber. (Item 1196) The system according to item 1187, wherein the energy storage member includes a solid pellet member. (Item 1197) The system according to item 1196, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrene polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubber. (Item 1198) The system according to item 1192, wherein the spring comprises a single, generally helical coil. (Item 1199) The system according to item 1192, wherein the spring comprises a plurality of generally helical coils. (Item 1200) The system according to item 1199, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned coaxially. (Item 1201) The system according to item 1199, wherein at least two of the coils, which include the plurality of generally helical coils, are aligned parallel to each other in the longitudinal direction. (Item 1202) The system described in item 1200, wherein the helical coils aligned on the coaxial axis are also aligned parallel to the longitudinal direction. (Item 1203) The system according to item 1202, wherein the coaxially aligned and longitudinally parallel spiral coils are wound spirally in opposite winding directions to each other so as to prevent interference between the coils when they are compressed. (Item 1204) The system according to claim 1187, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 1205) The system according to item 1146, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger into the syringe body. (Item 1206) The system according to item 1146, comprising a plunger distal end threaded joint configured such that the plunger is helically inserted into the stopper member and thereby connected to the stopper member. (Item 1207) The system according to item 1146, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on the surface of the plunger member, the ratchet mechanisms configured to prevent the plunger member from being reinserted into the syringe body after the plunger member has been initially inserted into a predetermined position in the syringe body. (Item 1208) The system according to item 1207, wherein the predetermined position is the position in which the stopper member has advanced to the position in which the plunger member has been fully inserted into the syringe body. (Item 1209) The system according to item 1207, further comprising a locking member operably connected between the plunger member and the syringe body, wherein the locking portion comprises at least one ratchet tooth that can engage with the ratchet mechanism and a proximal joint that can engage with the handle portion of the syringe body. (Item 1210) The system according to item 1189, further comprising a trigger engaging member connected to the syringe body and configured to engage with the trigger portion of the locking member through a trigger engaging window defined through at least a portion of the plunger member. (Item 1211) The system according to item 1146, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is generated when the stopper is inserted into the internal drug chamber. (Item 1212) The system according to item 1211, further comprising a braking member operably connected to the plunger member and the syringe body, wherein the braking member facilitates the insertion of the plunger member into the syringe body, but resists the retraction of the plunger member into the syringe body in a first mode until the braking member is positioned in a second mode of a release configuration. (Item 1213) The system according to item 1212, wherein the braking member comprises a plate aperture braking section. (Item 1214) The system according to item 1213, wherein the plate aperture braking portion includes a piece of sheet metal through which an aperture is formed. (Item 1215) The system according to claim 1210, further comprising a spring member configured to facilitate the retraction of the plunger into the syringe body after the plunger has been fully inserted into the syringe body. (Item 1216) The system according to item 1215, wherein the plate aperture braking unit is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 1217) The system according to item 1212, wherein the retraction of the plunger member is facilitated in the second mode by the application of a retraction start load. (Item 1218) The system according to item 1217, wherein the storage start load is applied by a spring member operably connected to the braking member. (Item 1219) The system according to item 1217, wherein the storage start load is applied by a spring member connected between the plunger member and the syringe body. (Item 1220) The system according to item 1218, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 1221) The system according to item 1219, wherein the spring member is selected from the group consisting of coil springs, leaf springs, and elastomer spring elements. (Item 1222) The system according to item 1211, wherein the vacuum load is sufficient to retract the plunger at least partially relative to the syringe body. (Item 1223) The system according to claim 1222, wherein the storage of the plunger stores the interconnected stopper member and needle, and as a result, at least a portion of the needle is drawn into the internal drug chamber of the syringe body. (Item 1224) The system according to item 1146, wherein the drug chamber is defined by the length of the chamber, and the needle is defined by the length of the needle, which is greater than or equal to the length of the chamber. (Item 1225) The system according to item 1224, further comprising an extension member connected to the proximal end of the syringe body, wherein the extension member is operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into the volume defined by the internal drug chamber and the extension member. (Item 1226) The syringe body further comprises an extension member connected to its proximal end, the extension member being operably connected to the plunger member and configured to accommodate the stopper member when the stopper is retracted to such an extent that it is at least partially out of the internal drug chamber, the extension member comprising a fluid-retaining surface positioned directly adjacent to the distal surface when the stopper member is retracted into the extension chamber, the fluid-retaining surface being configured to contain residual droplets of the drug, and the extension member may remain connected to the distal surface of the stopper member until they are contained by the fluid-retaining surface, item 1 The system described in 146. (Item 1227) The system according to item 1146, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle is structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1228) The system according to item 1227, wherein the distal end of the needle is structurally encapsulated within the internal drug chamber. (Item 1229) The distal end of the needle is structurally encapsulated by a needle door member, the needle door member is movably connected to the syringe body, and the device is configured to have a first state in which the needle door member facilitates the insertion of the needle into the syringe body, and a second state in which the needle door member prevents the insertion of the needle into the syringe body, item 122 The system described in 7. (Item 1230) It is a system for injection, a. Syringe body defining the internal drug chamber, and distal needle connection, b. A stopper member configured to be inserted into the internal drug chamber in order to contain the drug within the drug chamber, c. A plunger member, which is configured to be manually operated for inserting the stopper member into the syringe body, d. A needle having a proximal end and a distal end, wherein the proximal end is detachably attached to the distal needle joint of the syringe body, e. A needle sealing portion operably connected between the needle and the distal needle joint, configured to prevent fluid flow between the outer surface of the needle and the distal needle joint, A system in which the needle is connected to at least one radially projecting locking mechanism, the locking mechanism being connected to a mechanical locking portion to prevent axial movement of the needle relative to the syringe in a locked configuration, and to facilitate the movement of the needle relative to the syringe body in a non-locked configuration. (Item 1231) The system according to item 1230, wherein the needle has a pointed distal end. (Item 1232) The system according to item 1230, comprising a pointed proximal end configured to pierce at least a portion of the stopper member. (Item 1233) The system according to item 1230, further comprising a locking joint surface connected to the distal needle joint and configured to mechanically facilitate the locking configuration. (Item 1234) The locking joint surface is formed into the distal portion of the syringe body, item 1233 The system described above. (Item 1235) The system according to item 1233, wherein the locking joint surface comprises a separate locking joint member that is operably connected to the syringe body. (Item 1236) The system according to item 1233, wherein the locking configuration wherein the radially protruding locking mechanism is connected to a recess formed in the locking joint surface. (Item 1237) The system according to item 1233, wherein, in a non-locking configuration, the radially projecting locking mechanism aligns with an aperture formed in the locking joint surface to facilitate the passage of the radially projecting locking mechanism through the locking joint surface so that the needle can be inserted into or retracted into the syringe body. (Item 1238) The system according to item 1236, wherein in a non-locking configuration, the radially projecting locking mechanism is aligned with an aperture formed in the locking joint surface that facilitates the passage of the radially projecting locking mechanism through the locking joint surface so that the needle can be inserted into or retracted into the syringe body, and the depression and aperture are in different radial positions relative to each other on the locking joint surface such that the rotation of the needle between radial positions changes state between the locking configuration and the non-locking configuration. (Item 1239) The system according to item 1238, wherein the radial positions of the depressions and apertures are separated from each other at approximately 60 degrees on the locking joint surface. (Item 1240) The system according to item 1232, wherein the twisted portion of the needle member intervenes between the pointed proximal end and the distal end of the needle, and the twisted portion is configured to rotate the needle relative to the stopper when the pointed proximal end and at least a portion of the twisted portion are inserted into the stopper. (Item 1241) The system according to item 1230, comprising a first compliant member, wherein the needle sealing portion is configured to be compressed in the locked state in order to maintain the locked state of the needle, and to be further compressed to facilitate conversion to an unlocked configuration. (Item 1242) The system according to item 1241, further comprising a sealing backing member connected to the first compliant member and configured to substantially maintain the geometry of the central portion of the first compliant member with respect to the needle and to reduce contact friction between the needle and the first compliant member. (Item 1243) The system described in item 1230, wherein the syringe body includes a commercially available syringe body. (Item 1244) The system according to item 1230, wherein the syringe body generally has a cylindrical geometric shape. (Item 1245) The system according to item 1230, wherein the drug chamber is configured to contain approximately 0.5 cc to approximately 5 cc of drug. (Item 1246) The system according to item 1245, wherein the drug chamber is configured to contain a volume of drug selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 1247) The system according to item 1230, wherein the syringe body includes a glass material. (Item 1248) The system according to item 1230, wherein the syringe body comprises a polymer material. (Item 1249) The system according to item 1248, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1250) The system described in item 1230, wherein the syringe body contains metal. (Item 1251) The system according to item 1230, wherein the syringe body has a distal outer geometry configured to be mechanically connected to one or more other device elements. (Item 1252) The system according to item 1251, wherein the distal outer geometry of the syringe body includes a Luer lock joint. (Item 1253) The system according to item 1251, wherein the distal outer geometry of the syringe body includes a Luer taper joint. (Item 1254) The system described in item 1230, wherein the syringe body defines the distal drug port. (Item 1255) The system according to item 1254, wherein the needle has a maximum outer diameter selected so that it can be inserted through the distal drug port of the syringe body. (Item 1256) The system according to item 1255, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1257) The system according to item 1256, wherein the needle has a size of approximately 34 gauge to approximately 20 gauge. (Item 1258) The system according to item 1230, wherein the stopper member is configured to be at least partially penetrated by the pointed proximal end of the needle. (Item 1259) The system according to item 1230, comprising at least one anchor element configured to resist withdrawal after the needle has at least partially penetrated the stopper member. (Item 1260) The system according to item 1259, wherein the at least one anchor element is selected from the group consisting of overhang, skybead cut, hook geometry, arrowhead geometry, corrugated radial geometry, expanding faceted overhang configuration, and deformable member configured to be insertable in a relatively small cross-sectional state and deformable in a larger cross-sectional state. (Item 1261) The system according to item 1230, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body in order to substantially seal together with the syringe body. (Item 1262) The system according to item 1230, wherein the stopper comprises an elastomer material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1263) The system according to item 1230, further comprising a sealing coating applied to at least a portion of the stopper in order to isolate the pharmaceutical material from the stopper. (Item 1264) The system according to item 1263, wherein the sealing coating comprises a PTFE film. (Item 1265) The system according to item 1230, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1266) The system according to item 1265, wherein the lubricating layer contains silicone oil. (Item 1267) The system according to item 1230, wherein the distal portion of the stopper member includes a conventional commercially available compliant stopper. (Item 1268) The system according to item 1267, wherein the stopper member comprises an unmodified solid compliant member that does not have a recess or protrusion for connection to a needle. (Item 1269) The system according to item 1230, wherein the needle comprises at least one radially protruding locking surface mechanism. (Item 1270) The system according to item 1269, wherein the proximal end of the needle comprises at least one through element located proximal to at least one anchor element. (Item 1271) The system according to item 1270, wherein the through-element has a pointed tip. (Item 1272) The system according to item 1271, wherein the through-element is a solid structure and has no lumen or aperture defined through it. (Item 1273) The system according to item 1271, wherein the needle defines an injection passage through which it passes, and the injection passage is selected to lead from the distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 1274) The system according to item 1269, wherein the needle comprises a cannula member, a hub member, and a proximal member...

Claims

1. A system for mixing and injecting pharmaceutical preparations, wherein the system is A syringe body (34), wherein the syringe body (34) defines a proximal opening and a distal needle connection portion at its distal end, The proximal and distal stopper members (32, 36) are disposed within the syringe body (34), wherein the proximal and distal stopper members (32, 36) form a proximal drug chamber between the proximal and distal stopper members (32, 36), and form a distal drug chamber between the distal stopper member (36) and the distal end of the syringe body (34), A plunger member that defines the inside of the plunger, wherein the plunger member is configured to insert the proximal stopper member (32) into the syringe body (34), A needle having a proximal end (50) Equipped with, The proximal and distal stopper members (32, 36) are configured such that, before the proximal end (50) of the needle penetrates the distal stopper member (36), the distal movement of the proximal stopper member (32) causes the distal stopper member (36) to move distally, thereby causing the proximal end (50) of the needle to penetrate the distal stopper member (36), and so that the needle forms a fluid passage between the proximal drug chamber and the distal drug chamber. A system in which the transfer of a drug from the proximal drug chamber to the distal drug chamber through the fluid passage is initiated by moving the distal stopper member (36) distally and inserting the plunger member to allow the distal stopper member (36) to pass through the proximal end (50) of the needle.

2. The system according to claim 1, wherein the proximal end of the needle (50) is configured to enter the plunger when the plunger is inserted to move the proximal and distal stopper members (32, 36) distally to the distal end of the distal drug chamber.

3. The system according to claim 1, wherein the proximal and distal drug chambers each contain first and second components of a drug that are mixed before being injected into the patient.

4. The system according to claim 3, wherein the first component is a fluid and the second component is a solid.

5. The aforementioned needle is Proximal mixing opening and Distal mixing opening and The system according to claim 1, comprising:

6. The system according to claim 5, wherein a fluid passage is formed between the proximal drug chamber and the distal drug chamber when the proximal end (50) of the needle penetrates distally through the distal stopper member (36).

7. The aforementioned needle is Proximal injection opening and Distal injection opening and The system according to claim 5, further comprising:

8. The aforementioned needle is The system according to claim 7, further comprising a lumen plug disposed within the needle between the distal mixing opening and the proximal injection opening.

9. The system according to claim 8, wherein the fluid passage allows for mixing of the first and second components in the proximal and distal drug chambers.

10. The system according to claim 8, wherein the proximal and distal stopper members (32, 36) are configured such that further distal movement of the proximal and distal stopper members (32, 36) causes the mixed drug to pass through the proximal injection opening, through the needle, and out of the distal injection opening into the patient.

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